CN105286797A - Vertical type rotary fluorescent molecular tomographic imaging system and imaging method thereof - Google Patents
Vertical type rotary fluorescent molecular tomographic imaging system and imaging method thereof Download PDFInfo
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Abstract
The invention discloses a vertical type rotary fluorescent molecular tomographic imaging system and an imaging method thereof. The imaging system comprises an excitation light source device, a laser light path device, a fluorescent detection device, a rotary table, an examination bed, a horizontal moving table, a winding reel and a computer. The laser light path device enables the cumbersome excitation light source device to be fixed to a bottom plate without rotation along with the system, and excitation light can scan an examined body in 360 degrees through some rows of plane mirrors; the wavelength of the excitation light can be freely selected from a visible band to an infrared band according to needs, the excitation light with different wavelengths can be conveniently achieved for illumination, and thus imaging of multi-wavelength fluorescent probes is achieved; a dotted excitation light source or a linear excitation light source or a dot-area array excitation light source can be freely selected, and the shape of the excitation light is modulated according to experiment demands; open type design is adopted for an animal bed, the animal bed is made of a non-transparent material, the problem of light leakage and overexposure caused by the animal bed is solved, and data stability is improved.
Description
Technical field
The present invention relates to biomedical optical fluorescent technique, be specifically related to a kind of vertical rotating fluorescent molecular tomography system and formation method thereof.
Background technology
Fluorescent molecules imaging technology is widely used in carrying out, at the image method of body, the research of noinvasive quantitative and qualitative analysis, playing an important role in the research of its early diagnosis in disease, drug action mechanism and research and development and curative effect evaluation etc. to the change of organism physiology, pathology on a molecular scale.See according to working method, fluorescent molecules imaging system can be divided into the reflective fluorescence imaging (Epi-illuminationImaging) of plane formula and the fluorescent molecular tomography (FluorescenceMolecularTomography, FMT) two kinds of chromatography type.FMT is a diffusion according to light and absorbent properties, utilizes the emergent light information of exciting light and tested sample to rebuild the technology of specificity fluorescent group position and concentration distributed in three dimensions information.FMT can realize animal at body Non-invasive detection, there is low cost, high flux, high sensitivity, without ionizing radiation, can the plurality of advantages such as detection by quantitative for a long time.Relative to reflective fluorescence imaging, FMT can provide the space distribution situation of fluorescent material, and the pathology of detection deep tissues and function information, have more scientific research and Diagnostic Superiority.
The method that after early stage FMT system adopts animal to immerse matching fluid imaging chamber, optical fiber contact is measured.The people such as Harvard University medical college Deliolanis in 2007 propose 360 ° of non-contact fluorescence molecular tomography devices first.Animal is placed between the imaging platform of light source and CCD camera formation.Relative rotating 360 degrees between animal with imaging system in imaging process.But tested animal is hung at vertical direction in this device, realizing relatively rotating by rotating animal, in experimentation, easily destroying the original form of animal, be difficult to control the displacement of animal in rotary course, exacerbate the uncomfortable property of animal simultaneously.
Along with the development of fluorescent molecular tomography, there is increasing system design, but be all difficult to take into account the factors such as imaging effect, wavelength chooses motility, animal be fixing, have open defect and deficiency.The FMT series of PerkinElmer company adopts toy horizontal positioned, and light source and detector are positioned at animal both sides.It uses the mode of array light source scanning, the three-dimensional fluorescence imaging of toy is realized when achieving non rotating animal, such product with compact structure, frame for movement is simple, and the original form of animal can not be destroyed, but seriously restricted owing to gathering direction, extremely Dependent Algorithm in Precision, poor to the homogeneity of mice phosphor dot sensitivity response everywhere, imaging effect is poor.The BioFLECT product of Trifoil company have employed fixing excitation source, the mechanical design structure that detector rotates around mice, the mode of the irradiation of this single direction adds the inaccuracy of algorithm, and the individual variation of animal is also larger have impact on imaging results.
Luo Qing inscription afterwards waits the rotary fluorescent molecular tomography system of one proposed.This system is by toy horizontal positioned, and experiment porch rotates around toy, realizes the data acquisition of 360 °.This system source is semiconductor laser, limits the selection of wavelength, cannot according to the demand adjustment excitation wavelength of test, and application is restricted.If use the light source such as halogen tungsten lamp, xenon lamp as exciting light, then instrument rotation twist problem of optical fiber and data wire in rotary course is difficult to solve.The transmitting device that the fluorescent molecular tomography of University of California GultekinGulsen laboratory and design have employed drag chain type is attempted to solve circuit distortion problem, the an autumn real laboratory of Peking University devises bobbin winoler and optical fiber switching device shifter is attempted to solve circuit distortion and imaging pattern switching problem, but it is lengthy and jumbled to there is such as structure, often rotating to an angle all must by tool reset; Instrument needs ceaselessly twisted optical fiber in running, and optical fiber ruggedness is declined; The problems such as optic path inefficiency.
Meanwhile, FMT is high-precision Experiments of Optics, and the optical property of the animal beds of carrying animal often affects the imaging effect of experiment.Animal beds can will introduce a large amount of noise signals to the reflection of light and refraction in imaging.In order to avoid the introducing of noise, normally used animal beds ensures that bed body is transparent as far as possible, but effect is often undesirable.Due to zoomorphism difference, there will be the phenomenon such as overexposure, light leak in some angle, have impact on stability and the repeatability of experiment.
Summary of the invention
For above problems of the prior art, the present invention proposes a kind of vertical rotating fluorescent molecular tomography system and formation method thereof, farthest maintain the form stable of detection bodies, simplify optical path transmission device, have employed new-type animal beds mentality of designing.
For above problems of the prior art, the present invention proposes a kind of vertical rotating fluorescent molecular tomography system, farthest maintains the form stable of inspected body, simplifies optical path transmission device, have employed new-type animal beds mentality of designing.
One object of the present invention is to propose a kind of vertical rotating fluorescent molecular tomography system.
Vertical rotating fluorescent molecular tomography system of the present invention comprises: excitation light source device, laser optical path device, fluorescence detection device, turntable, examinating couch, translation stage, reel and computer; Wherein, excitation light source device is fixed on base plate; Turntable is arranged on base plate, and centre has through hole, during imaging with the axis of through hole for rotating shaft rotates; Laser optical path device and fluorescence detection device are installed on a spinstand respectively by respective connector; Examinating couch is arranged on translation stage, with the through hole of turntable in the same horizontal line, accessiblely in through-holes to pass through; Fluorescence detection device is connected to computer by data wire, and is connected to power supply by power line; Reel and turntable coaxial, data wire and power line are wrapped on the outer wall of reel according to the direction contrary with the direction of rotation of turntable; Laser optical path device comprises rotation synchronous plane mirror and plane of scanning motion mirror; During imaging, excitation light source device launches the exciting light of point source; Exciting light through reel, is incident to the rotation synchronous plane mirror of laser optical path device along rotating shaft; Through rotating exciting light and the examinating couch synchronous rotary of the reflection of synchronous plane mirror; Exciting light is incident to the plane of scanning motion mirror of laser optical path device after rotating the reflection of synchronous plane mirror, through the exciting light of the plane of scanning motion mirror examinating couch scanned and the shape of exciting light is modulated, final exciting light incides in the inspected body on examinating couch, produces fluorescence; Fluorescence detection device receives fluorescence; Fluorescence detection device converts fluorescence signal to electric signal transmission to computer.
Turntable comprises swivel plate, motor and bracing frame; Wherein, motor is arranged on base plate by bracing frame; Swivel plate is arranged on motor, carries out 360 degree of rotations by driven by motor; Swivel plate has through hole, with examinating couch on a horizontal line, allows that examinating couch is accessible in through-holes passes through.
The routing device of power supply and data adopts reel, reel is fixing on a spinstand by connector, or be fixed on base plate by gripper shoe, reel and turntable coaxial, be wrapped on the outer wall of reel by data wire and power line according to a direction, during imaging, the direction of rotation of turntable is contrary with direction of winding, like this when imaging, along with turntable rotates, power line and data wire are decontroled, and the problem of wire being wound and combing can not occur.One end of reel adopts connector fixing on a spinstand, and rotate with turntable, the other end is connected with gripper shoe by bearing, and gripper shoe is fixed on base; Or one end of reel is connected by bearing with the connector of fixed laser light path device, the other end is fixing on the supporting plate, does not rotate with turntable.The other end of reel arranges gripper shoe, thus makes the two ends uniform force of device.
Excitation light source device comprises LASER Light Source, luminous source optical fiber and filtering apparatus; Wherein, LASER Light Source is fixed on base plate launches exciting light, and exciting light is derived by luminous source optical fiber, sends the exciting light that spectrum continuous print collimation is high, is incident to filtering apparatus; Exciting light is filtered into the good exciting light of monochromaticity by filtering apparatus, and keeps collimation constant, is incident to laser optical path device.
Laser optical path device comprises rotation synchronous plane mirror and plane of scanning motion mirror; The exciting light passing reel along rotating shaft is incident to rotation synchronous plane mirror, reflects rear and examinating couch synchronous rotary; Be incident to the plane of scanning motion mirror of laser optical path device, through the exciting light of the plane of scanning motion mirror examinating couch scanned and the shape of exciting light is modulated.The light source type being incident to examinating couch as required selects plane of scanning motion mirror, if the light source being incident to examinating couch is point source, then plane of scanning motion mirror is reflecting mirror; If the light source being incident to examinating couch is line source, then plane of scanning motion mirror is one dimension galvanometer; If the light source being incident to examinating couch is array light source, then plane of scanning motion mirror is 2-D vibration mirror.Further, laser optical path device also comprises the first reflecting mirror, is fixed on base plate, is arranged on exciting light that the excitation light source device on base plate emits through the first reflecting mirror reflection tailing edge rotating shaft through reel.Laser optical path device simplifies the system design exciting end, heavy excitation light source device is made no longer to need system for tracking to rotate, exciting light is by a series of plane mirror transmission in laser optical path device, avoid the problems such as Optical Fiber Winding, and can experimentally demand, the light spot shape that free adjustment needs and lighting system.
Examinating couch comprises fixture, animal beds, gas anesthesia device and heating installation; Wherein, one end of fixture is connected with translation stage, and the other end connects animal beds, and room is left in inside; Gas anesthesia device and heating installation, by the room in fixture, provide numb gas and heating installation respectively to animal beds; Animal beds is circular arc or plate shaped; Animal beds adopts at visible light wave range and the scattering of near infrared light wave band and the optical property of the absorption material consistent with inspected body.The thickness of animal beds is relevant with the hardness of adopted material, and thickness and hardness are inversely proportional to, and makes animal beds be enough to support inspected body.Animal beds adopts open by design, and inspected body lies directly on open animal beds, is convenient to experimental implementation, is convenient to picking and placeing of inspected body simultaneously, also can not affect position and the level of comfort of inspected body; Animal beds adopts the scattering medium of the skin histology optical property of similar inspected body, the problems such as the overexposure avoiding animal beds to cause, light leak.
Translation stage is arranged on base, and examinating couch is arranged on translation stage, does horizontal movement along translation stage, thus the through hole in turnover turntable.
Fluorescence detection device fixes the side sending fluorescence on a spinstand by connector, receive fluorescence signal, and convert fluorescence signal to electric signal transmission to computer.Fluorescence detection device comprises reception filtering assembly, camera lens and detector.The power supply of detector and data are wound around on a bobbin according to the direction contrary with the direction of rotation of turntable.
Another object of the present invention is to propose a kind of vertical rotating fluorescent molecular tomography method.
Vertical rotating fluorescent molecular tomography method of the present invention, comprises the following steps:
1) connecting device: fluorescence detection device is connected to computer by data wire, and be connected to power supply by power line, reel and turntable coaxial, data wire and power line are wrapped on the outer wall of reel according to the direction contrary with the direction of rotation of turntable;
2) excitation light source device launches the exciting light of point source;
3) exciting light is along rotating shaft through reel, is incident to the rotation synchronous plane mirror of laser optical path device;
4) exciting light after rotating the reflection of synchronous plane mirror with examinating couch synchronous rotary;
5) exciting light is incident to the plane of scanning motion mirror of laser optical path device after rotating the reflection of synchronous plane mirror, to scan and modulate the shape of exciting light through the exciting light of plane of scanning motion mirror to examinating couch;
6) exciting light incides in the inspected body on examinating couch, produces fluorescence;
7) fluorescence detection device receives fluorescence, converts fluorescence signal to the signal of telecommunication, and transfers to computer;
8) computer receiving data, uses fluorescence algorithm for reconstructing to rebuild faultage image, and carries out image display.
Advantage of the present invention:
1) laser optical path device makes heavy excitation light source device can be fixed on base plate not rotate with system, makes exciting light can 360 ° of scanning inspected bodys by some row plane mirrors;
2) exciting light wavelength can as required visible to infrared band unrestricted choice, the excitation light irradiation of different wave length can be realized easily, thus realize the imaging of multi-wavelength fluorescent probe;
3) be free to select point-like excitation source, wire excitation source or some face battle array excitation source, experimentally the shape of demand to exciting light is modulated;
4) animal beds adopts open by design, adopts non-transparent material, solves light leak and overexposure phenomenon that animal beds causes, improves the stability of data;
5) without the need to moving or taking off inspected body, picture region can be adjusted under the movement of translation stage, also the system of other mode can be delivered to through turntable, as X-ray computer tomography X-rayCT, PET-Positron emission computed tomography imaging PET, single photon emission computerized tomography SPECT etc., carry out multi-modality imaging, farthest maintain the form stable of inspected body, simplify the step of image registration simultaneously.
Accompanying drawing explanation
Fig. 1 is the structural representation of an embodiment of vertical rotating fluorescent molecular tomography system of the present invention;
Fig. 2 is the schematic diagram of the turntable of vertical rotating fluorescent molecular tomography system of the present invention;
Fig. 3 is the schematic diagram of the excitation light source device of vertical rotating fluorescent molecular tomography system of the present invention;
Fig. 4 is the schematic diagram of an embodiment of the laser optical path device of vertical rotating fluorescent molecular tomography system of the present invention;
Fig. 5 is the structural representation of the fluorescence detection device of vertical rotating fluorescent molecular tomography system of the present invention;
Fig. 6 is the schematic diagram of vertical rotating fluorescent molecular tomography system animal beds of the present invention.
Detailed description of the invention
Below in conjunction with accompanying drawing, by embodiment, the present invention will be further described.
As shown in Figure 1, the vertical rotating fluorescent molecular tomography system of the present embodiment comprises: excitation light source device 1, laser optical path device 2, fluorescence detection device 3, turntable 4, examinating couch 5, translation stage 8, reel 7 and computer; Wherein, excitation light source device 1 is fixed on base plate 6; Turntable 4 is arranged on base plate 6; Laser optical path device 2 and fluorescence detection device 3 are arranged on turntable 4 respectively by respective connector; Examinating couch 5 is arranged on translation stage 6, with the through hole of turntable in the same horizontal line, accessiblely in through-holes to pass through; Fluorescence detection device 3 is connected to computer by data wire, and is connected to power supply by power line; Reel 7 is coaxial with turntable, and data wire and power line are wrapped on the outer wall of reel 7 according to the direction contrary with the direction of rotation of turntable; The fluorescence that exciting light produces after being incident to the inspected body of examinating couch, is received by detector 3 after reflecting mirror reflection.
As shown in Figure 2, turntable 4 comprises swivel plate 41, motor 42 and bracing frame 43; Wherein, motor 42 is arranged on base plate 6 by bracing frame 43; Swivel plate 41 is arranged on motor 42, carries out 360 degree of rotations by driven by motor; Swivel plate has through hole, with examinating couch on a horizontal line, allows that examinating couch is accessible in through-holes passes through.
As shown in Figure 3, excitation light source device 1 comprise excitation source 11, excite filtering assembly 12, plane mirror 13 and mirror support 14; Wherein, light source 11 sends continuous print exciting light, enter and excite filtering assembly 12, excite filtering assembly 12 to adopt optical filter wheel, the multiple optical filter of inner placement, selects the exciting light of suitable wavelength as required, after filtering, exciting light plane mirror 13 reflects, enter laser optical path device 2, plane mirror 13 is arranged on reflector mount 14, and reflector mount 14 is arranged on base plate 6.
As shown in Figure 4, laser optical path device 2 comprises rotation synchronous plane mirror 22 and plane of scanning motion mirror 24; Rotating synchronous plane mirror 22 is arranged on swivel plate 41 by connecting plate 25; Plane of scanning motion mirror 24 is arranged on swivel plate 41; The exciting light sent from excitation source 11 is reflected into through plane mirror 13 and is incident upon the first reflecting mirror 21, then after the first reflecting mirror 21 reflects, along rotating shaft through reel 7, is incident to and rotates synchronous plane mirror 22; Exciting light through rotating synchronous plane mirror 22 is incident to plane of scanning motion mirror 24 after the second plane mirror 23 reflects, and plane of scanning motion mirror is modulated exciting light shape.Laser optical path device 2 adopts connecting plate 25 with the connector of turntable.
Reel 7 is together arranged on connecting plate 25 with rotation synchronous plane mirror 22, thus fix on a spinstand, one end that reel 7 is connected with connecting plate 25 maintains static, and rotates with turntable, the other end installs on the supporting plate 71 by bearing, thus makes the two ends uniform force of device.
As shown in Figure 5, fluorescence detection device 3 comprise receive filtering assembly 31, camera lens 32 and detector 33, camera lens 32 is installed before the detectors, before filtering assembly 31 is installed, detector 33 is enclosed within pressure ring 34, and is fixed by block 35, is arranged on fixing head 36.Fluorescence detection device is fixed on the swivel plate 41 of turntable 4 by connecting rod, by the reflection of the plane mirror at 45 ° with the fluorescence sent, receives fluorescence signal.The data wire of reception filtering assembly 31 and detector 33 and power line are wrapped in the outer wall of reel respectively according to the direction contrary with the direction of rotation of turntable.Fluorescence detection device 3 adopts connecting rod with the connector of turntable.The fluorescence that inspected body produces, after reflecting mirror 37, is received by fluorescence detection device.
As shown in Figure 6, examinating couch 5 comprises fixture 51, animal beds 54, gas anesthesia device 52 and heating installation 53; Wherein, one end of fixture 51 is connected with translation stage, and the other end connects animal beds 54, the inner trachea passing through gas anesthesia device 52 and heating installation 53; Gas anesthesia device 52 and heating installation 53 are arranged in fixture 51 respectively; Animal beds is plate shaped; Animal beds adopts the scattering medium of the optical property of similar animal skin tissue, employs the material of polyformaldehyde (polyformaldehyde) as animal beds, the problems such as the overexposure avoiding animal beds to cause, light leak in the present embodiment.
It is finally noted that, the object publicizing and implementing mode is to help to understand the present invention further, but it will be appreciated by those skilled in the art that: without departing from the spirit and scope of the invention and the appended claims, various substitutions and modifications are all possible.Therefore, the present invention should not be limited to the content disclosed in embodiment, and the scope that the scope of protection of present invention defines with claims is as the criterion.
Claims (10)
1. a vertical rotating fluorescent molecular tomography system, is characterized in that, described imaging system comprises: excitation light source device, laser optical path device, fluorescence detection device, turntable, examinating couch, translation stage, reel and computer; Wherein, described excitation light source device is fixed on base plate; Described turntable is arranged on base plate, and centre has through hole, during imaging with the axis of through hole for rotating shaft rotates; Described laser optical path device and fluorescence detection device are installed on a spinstand respectively by respective connector; Described examinating couch is arranged on translation stage, with the through hole of turntable in the same horizontal line, accessiblely in through-holes to pass through; Described fluorescence detection device is connected to computer by data wire, and is connected to power supply by power line; Described reel and turntable coaxial, data wire and power line are wrapped on the outer wall of reel according to the direction contrary with the direction of rotation of turntable; Described laser optical path device comprises rotation synchronous plane mirror and plane of scanning motion mirror; During imaging, excitation light source device launches the exciting light of point source; Exciting light through reel, is incident to the rotation synchronous plane mirror of laser optical path device along rotating shaft; Through rotating exciting light and the examinating couch synchronous rotary of the reflection of synchronous plane mirror; Exciting light is incident to the plane of scanning motion mirror of laser optical path device after rotating the reflection of synchronous plane mirror, through the exciting light of the plane of scanning motion mirror examinating couch scanned and the shape of exciting light is modulated, final exciting light incides in the inspected body on examinating couch, produces fluorescence; Described fluorescence detection device receives fluorescence; Described fluorescence detection device converts fluorescence signal to electric signal transmission to computer.
2. imaging system as claimed in claim 1, is characterized in that, the light source type being incident to examinating couch as required selects plane of scanning motion mirror, if the light source being incident to examinating couch is point source, then plane of scanning motion mirror is reflecting mirror; If the light source being incident to examinating couch is line source, then plane of scanning motion mirror is one dimension galvanometer; If the light source being incident to examinating couch is array light source, then plane of scanning motion mirror is 2-D vibration mirror.
3. imaging system as claimed in claim 1, is characterized in that, comprise the first reflecting mirror further, be fixed on base plate; The rotation synchronous plane mirror of described laser optical path device is installed on a spinstand by connecting plate; Described plane of scanning motion mirror is installed on a spinstand; The exciting light sent from excitation light source device, after the first reflecting mirror reflection, along rotating shaft through reel, is incident to and rotates synchronous plane mirror; Plane of scanning motion mirror is incident to after rotating the reflection of synchronous plane mirror.
4. imaging system as claimed in claim 1, is characterized in that, one end of described reel adopts connector fixing on a spinstand, and rotate with turntable, the other end is connected with gripper shoe by bearing, and described gripper shoe is fixed on base.
5. imaging system as claimed in claim 1, it is characterized in that, one end of described reel is connected by bearing with the connector of fixed laser light path device, and the other end is fixing on the supporting plate, and do not rotate with turntable, described gripper shoe is fixed on base.
6. imaging system as claimed in claim 1, it is characterized in that, described excitation light source device comprises LASER Light Source, luminous source optical fiber and filtering apparatus; Wherein, described LASER Light Source is fixed on base plate launches exciting light, and exciting light is derived by luminous source optical fiber, sends spectrum continuous print collimation exciting light, is incident to filtering apparatus; Exciting light is filtered into monochromatic excitation light by described filtering apparatus, and keeps collimation constant, is incident to laser optical path device.
7. imaging system as claimed in claim 1, it is characterized in that, described examinating couch comprises fixture, animal beds, gas anesthesia device and heating installation; Wherein, one end of described fixture is connected with translation stage, and the other end connects animal beds, and room is left in inside; Described gas anesthesia device and heating installation, by the room in fixture, provide numb gas and heating installation respectively to animal beds.
8. imaging system as claimed in claim 7, it is characterized in that, described animal beds is circular arc or plate shaped; Described animal beds adopts at visible light wave range and the scattering of near infrared light wave band and the optical property of the absorption material consistent with inspected body.
9. a vertical rotating fluorescent molecular tomography method, is characterized in that, described formation method comprises the following steps:
1) connecting device: fluorescence detection device is connected to computer by data wire, and be connected to power supply by power line, reel and turntable coaxial, data wire and power line are wrapped on the outer wall of reel according to the direction contrary with the direction of rotation of turntable;
2) excitation light source device launches the exciting light of point source;
3) exciting light is along rotating shaft through reel, is incident to the rotation synchronous plane mirror of laser optical path device;
4) exciting light after rotating the reflection of synchronous plane mirror with examinating couch synchronous rotary;
5) exciting light is incident to the plane of scanning motion mirror of laser optical path device after rotating the reflection of synchronous plane mirror, to scan and modulate the shape of exciting light through the exciting light of plane of scanning motion mirror to examinating couch;
6) exciting light incides in the inspected body on examinating couch, produces fluorescence;
7) fluorescence detection device receives fluorescence, converts fluorescence signal to the signal of telecommunication, and transfers to computer;
8) computer receiving data, uses fluorescence algorithm for reconstructing to rebuild faultage image, and carries out image display.
10. formation method as claimed in claim 9, is characterized in that, the light source type being incident to examinating couch as required selects plane of scanning motion mirror, if the light source being incident to examinating couch is point source, then plane of scanning motion mirror is reflecting mirror; If the light source being incident to examinating couch is line source, then plane of scanning motion mirror is one dimension galvanometer; If the light source being incident to examinating couch is array light source, then plane of scanning motion mirror is 2-D vibration mirror.
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| CN114217055A (en) * | 2021-12-02 | 2022-03-22 | 极瞳生命科技(苏州)有限公司 | Portable fluorescence scanning detection device and method |
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