CN105274416A - Magnetic zirconia biological ceramic and preparation method thereof - Google Patents
Magnetic zirconia biological ceramic and preparation method thereof Download PDFInfo
- Publication number
- CN105274416A CN105274416A CN201510635449.XA CN201510635449A CN105274416A CN 105274416 A CN105274416 A CN 105274416A CN 201510635449 A CN201510635449 A CN 201510635449A CN 105274416 A CN105274416 A CN 105274416A
- Authority
- CN
- China
- Prior art keywords
- parts
- biological ceramics
- temperature
- magnetic oxygenated
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Compositions Of Oxide Ceramics (AREA)
Abstract
The invention discloses magnetic zirconia biological ceramic and a preparation method thereof and belongs to the field of biomedical materials. The magnetic zirconia biological ceramic is prepared from, by mass, 65.0-85.0 parts of nano-zirconia, 12.0-22.0 parts of nano-alumina, 5.5-9.5 parts of calcium phosphate, 2.5-5.0 parts of nickel powder, 3.0-6.0 parts of ultrafine ferroferric oxide, 2.0-5.0 parts ofaluminum silicate, 1.0-3.0 parts of zinc oxide and 0.5-1.0 parts of platinum powder. The preparation method of the magnetic zirconia biological ceramic includes the following steps that firstly, materials are prepared; secondly, pre-mixed materials are prepared; thirdly, high-temperature calcination is performed; fourthly, cooling is performed step by step; and fifthly, zirconia biological ceramic is taken out after being cooled. The zirconia biological ceramic has the beneficial effects of being good in mechanical performance and high in bio-compatibility; and meanwhile, magnetic functions are achieved, side effects caused after the biological ceramic is implanted can be reduced, and good using prospects are achieved.
Description
Technical field
The invention belongs to technical field of biological material, particularly the preparation method of a kind of magnetic oxygenated zirconium biological ceramics and this biological ceramics.
Background technology
Bioceramic material started from for 18 beginnings of the century as biomedical material, was developed so far, and had had multiple bioceramic material to may be used on biomedical sector.
Chinese pottery has a long history, but in biological ceramics field, China started to study in phase early 1970s, and for clinical.Within 1974, carry out the research of devitrified glass for joint prosthesis; Within 1977, alumina-ceramic obtains application clinically; Within 1979, high purity aluminium oxide monocrystalline is used for clinical, has again new bio stupalith constantly to occur later, and is applied to clinical.The range of application of current biological ceramics also progressively expands, now can be applicable to artificial bone, joint prosthesis, artificial dental root, bone compaction material, bone replacing material, synosteosis material, also can be applicable to artificial heart valve, artificial tendon, artificial blood vessel, artificial trachea, to can be applicable in body medical monitoring etc. through skin lead-in wire.
Human magnetic field belongs to biological magnetic field category, and along with further developing of detection technique, human magnetic field detects by Weak magentic-field assay method, and existing researching human body magnetic field is significant for the Diagnosis and Treat of some diseases.By the promoter action of external magnetic field to human magnetic field, certain result for the treatment of can be reached, i.e. magnetic therapy.At present, magnetic therapy is mainly reflected in the effect of analgesia, calmness, anti-inflammatory and detumescence for the therapeutic action of human body.And when human body implantable bioartificial material, multiple side effect also can be produced, being slowed down the impact of side effect by magnetic, is an important directions of biological ceramics development.
Summary of the invention
The technical problem that the present invention solves: for above-mentioned deficiency, overcome the defect of prior art, the object of this invention is to provide a kind of magnetic oxygenated zirconium biological ceramics and preparation method thereof.
Technical scheme of the present invention: a kind of magnetic oxygenated zirconium biological ceramics, is prepared from by each component of following mass fraction:
Nano zircite 65.0-85.0 part, nano aluminium oxide 12.0-22.0 part, calcium phosphate 5.5-9.5 part, nickel powder 2.5-5.0 part, ultra-fine Z 250 3.0-6.0 part, pure aluminium silicate 2.0-5.0 part, zinc oxide 1.0-3.0 part and platinum powder 0.5-1.0 part.
As preferably, described biological ceramics is prepared from by each component of following mass fraction: nano zircite 69.0-77.0 part, nano aluminium oxide 15.0-21.0 part, calcium phosphate 6.5-8.5 part, nickel powder 2.8-3.5 part, ultra-fine Z 250 4.5-5.5 part, pure aluminium silicate 3.0-4.0 part, zinc oxide 1.5-2.5 part and platinum powder 0.6-0.8 part.
More preferably, described biological ceramics is prepared from by each component of following mass fraction: nano zircite 73.0 parts, nano aluminium oxide 16.0 parts, calcium phosphate 7.5, part, nickel powder 3.2 parts, ultra-fine Z 250 5.3 parts, pure aluminium silicate 3.6 parts, 1.8 parts, zinc oxide and 0.7 part, platinum powder.
A preparation method for magnetic oxygenated zirconium biological ceramics, preparation process is as follows:
(1) get the raw materials ready: accurately take each component;
(2) prepare Preblend: each component mixed, put into grinding machine and grind, obtain Preblend;
(3) high-temperature calcination: mould is put in Preblend prepared by step (2), carry out high-temperature calcination under argon shield, temperature is 1220 DEG C-1350 DEG C, pressure 500-800MPa, time 2-5h;
(4) step cooling: after calcining, enters distribution cooling stages, the first stage, and temperature is dropped to 850 DEG C-900 DEG C, pressure remains unchanged, and continues 2h; Subordinate phase, temperature drops to 550 DEG C-600 DEG C further, and pressure progressively drops to 200-300MPa, time length 3h; Phase III, temperature is down to 350 DEG C-380 DEG C, Pressure Drop to 0, time length 5h; Final stage, naturally cooling;
(5) taking-up to be cooled, namely obtains block magnetic oxygenated zirconium biological ceramics.
As preferably, in step (3), the temperature of high-temperature calcination is 1280 DEG C.
As preferably, in step (3), the pressure of high-temperature calcination is 680MPa.
Beneficial effect: magnetic oxygenated zirconium biological ceramics provided by the invention is a kind of bio-inert ceramic with magnetic action.When biological ceramics implant into body, more or less can produce some adverse side effects with matrix, how overcome this detrimentally affect, have two kinds of developing direction.The first developing direction is, improves the biocompatibility of biological ceramics further; The second, be utilize the performance of biological ceramics to overcome this detrimentally affect.At present, main concern is the first developing direction in the industry, and have ignored the second developing direction.Magnetic oxygenated zirconium biological ceramics provided by the invention utilizes externally-applied magnetic field on the impact of human magnetic field, reached the effect of certain analgesia, calmness, detumescence and anti-inflammatory, thus reduce this detrimentally affect by " magnetic therapy ".
Therefore, magnetic oxygenated zirconium biological ceramics provided by the invention, not only has good mechanical property, the feature that biocompatibility is high, has magnetic action simultaneously, can reduce the side effect after biological ceramics is implanted, have good prospect of the application.
Embodiment
In order to understand the present invention further, below in conjunction with embodiment, the preferred embodiment of the invention is described, but should be appreciated that these describe just for further illustrating the features and advantages of the present invention, instead of limiting to the claimed invention.
Embodiment 1:
A kind of magnetic oxygenated zirconium biological ceramics, is prepared from by each component of following mass fraction:
Nano zircite 65.0 parts, nano aluminium oxide 12.0 parts, 5.5 parts, calcium phosphate, nickel powder 2.5 parts, ultra-fine Z 250 3.0 parts, pure aluminium silicate 2.0 parts, 1.0 parts, zinc oxide and 0.5 part, platinum powder.
A preparation method for magnetic oxygenated zirconium biological ceramics, preparation process is as follows:
(1) get the raw materials ready: accurately take each component;
(2) prepare Preblend: each component mixed, put into grinding machine and grind, obtain Preblend;
(3) high-temperature calcination: mould is put in Preblend prepared by step (2), carry out high-temperature calcination under argon shield, temperature is 1280 DEG C, pressure 680MPaMPa, time 5h;
(4) step cooling: after calcining, enters distribution cooling stages, the first stage, and temperature is dropped to 860 DEG C, pressure remains unchanged, and continues 2h; Subordinate phase, temperature drops to 600 DEG C further, and pressure progressively drops to 250MPa, time length 3h; Phase III, temperature is down to 360 DEG C, Pressure Drop to 0, time length 5h; Final stage, naturally cooling;
(5) taking-up to be cooled, namely obtains block magnetic oxygenated zirconium biological ceramics.
Performance Detection is carried out to the magnetic oxygenated zirconium biological ceramics of the bulk obtained: ultimate compression strength 1150MPa; Toughness 18MPam
1/2; Young's modulus 132GPa.
Embodiment 2:
A kind of magnetic oxygenated zirconium biological ceramics, is prepared from by each component of following mass fraction:
Nano zircite 85.0 parts, nano aluminium oxide 22.0 parts, 9.5 parts, calcium phosphate, nickel powder 5.0 parts, ultra-fine Z 250 6.0 parts, pure aluminium silicate 5.0 parts, 3.0 parts, zinc oxide and 1.0 parts, platinum powder.
A preparation method for magnetic oxygenated zirconium biological ceramics, preparation process is as follows:
(1) get the raw materials ready: accurately take each component;
(2) prepare Preblend: each component mixed, put into grinding machine and grind, obtain Preblend;
(3) high-temperature calcination: mould is put in Preblend prepared by step (2), carry out high-temperature calcination under argon shield, temperature is 1280 DEG C, pressure 680MPaMPa, time 2-5h;
(4) step cooling: after calcining, enters distribution cooling stages, the first stage, and temperature is dropped to 860 DEG C, pressure remains unchanged, and continues 2h; Subordinate phase, temperature drops to 600 DEG C further, and pressure progressively drops to 250MPa, time length 3h; Phase III, temperature is down to 360 DEG C, Pressure Drop to 0, time length 5h; Final stage, naturally cooling;
(5) taking-up to be cooled, namely obtains block magnetic oxygenated zirconium biological ceramics.
Performance Detection is carried out to the magnetic oxygenated zirconium biological ceramics of the bulk obtained: ultimate compression strength 1220MPa; Toughness 21MPam
1/2; Young's modulus 136GPa.
Embodiment 3:
A kind of magnetic oxygenated zirconium biological ceramics, is prepared from by each component of following mass fraction:
Nano zircite 69.0 parts, nano aluminium oxide 15.0 parts, 6.5 parts, calcium phosphate, nickel powder 2.8 parts, ultra-fine Z 250 4.5 parts, pure aluminium silicate 3.0 parts, 1.5 parts, zinc oxide and 0.6 part, platinum powder.
A preparation method for magnetic oxygenated zirconium biological ceramics, preparation process is as follows:
(1) get the raw materials ready: accurately take each component;
(2) prepare Preblend: each component mixed, put into grinding machine and grind, obtain Preblend;
(3) high-temperature calcination: mould is put in Preblend prepared by step (2), carry out high-temperature calcination under argon shield, temperature is 1280 DEG C, pressure 680MPaMPa, time 2-5h;
(4) step cooling: after calcining, enters distribution cooling stages, the first stage, and temperature is dropped to 860 DEG C, pressure remains unchanged, and continues 2h; Subordinate phase, temperature drops to 600 DEG C further, and pressure progressively drops to 250MPa, time length 3h; Phase III, temperature is down to 360 DEG C, Pressure Drop to 0, time length 5h; Final stage, naturally cooling;
(5) taking-up to be cooled, namely obtains block magnetic oxygenated zirconium biological ceramics.
Performance Detection is carried out to the magnetic oxygenated zirconium biological ceramics of the bulk obtained: ultimate compression strength 1170MPa; Toughness 18MPam
1/2; Young's modulus 133GPa.
Embodiment 4:
A kind of magnetic oxygenated zirconium biological ceramics, is prepared from by each component of following mass fraction:
Nano zircite 77.0 parts, nano aluminium oxide 21.0 parts, 8.5 parts, calcium phosphate, nickel powder 3.5 parts, ultra-fine Z 250 5.5 parts, pure aluminium silicate 4.0 parts, 2.5 parts, zinc oxide and 0.8 part, platinum powder.
A preparation method for magnetic oxygenated zirconium biological ceramics, preparation process is as follows:
(1) get the raw materials ready: accurately take each component;
(2) prepare Preblend: each component mixed, put into grinding machine and grind, obtain Preblend;
(3) high-temperature calcination: mould is put in Preblend prepared by step (2), carry out high-temperature calcination under argon shield, temperature is 1280 DEG C, pressure 680MPaMPa, time 2-5h;
(4) step cooling: after calcining, enters distribution cooling stages, the first stage, and temperature is dropped to 860 DEG C, pressure remains unchanged, and continues 2h; Subordinate phase, temperature drops to 600 DEG C further, and pressure progressively drops to 250MPa, time length 3h; Phase III, temperature is down to 360 DEG C, Pressure Drop to 0, time length 5h; Final stage, naturally cooling;
(5) taking-up to be cooled, namely obtains block magnetic oxygenated zirconium biological ceramics.
Performance Detection is carried out to the magnetic oxygenated zirconium biological ceramics of the bulk obtained: ultimate compression strength 1180MPa; Toughness 19MPam
1/2; Young's modulus 133GPa.
Embodiment 5:
A kind of magnetic oxygenated zirconium biological ceramics, is prepared from by each component of following mass fraction:
Nano zircite 73.0 parts, nano aluminium oxide 16.0 parts, calcium phosphate 7.5, part, nickel powder 3.2 parts, ultra-fine Z 250 5.3 parts, pure aluminium silicate 3.6 parts, 1.8 parts, zinc oxide and 0.7 part, platinum powder.
A preparation method for magnetic oxygenated zirconium biological ceramics, preparation process is as follows:
(1) get the raw materials ready: accurately take each component;
(2) prepare Preblend: each component mixed, put into grinding machine and grind, obtain Preblend;
(3) high-temperature calcination: mould is put in Preblend prepared by step (2), carry out high-temperature calcination under argon shield, temperature is 1280 DEG C, pressure 680MPaMPa, time 2-5h;
(4) step cooling: after calcining, enters distribution cooling stages, the first stage, and temperature is dropped to 860 DEG C, pressure remains unchanged, and continues 2h; Subordinate phase, temperature drops to 600 DEG C further, and pressure progressively drops to 250MPa, time length 3h; Phase III, temperature is down to 360 DEG C, Pressure Drop to 0, time length 5h; Final stage, naturally cooling;
(5) taking-up to be cooled, namely obtains block magnetic oxygenated zirconium biological ceramics.
Performance Detection is carried out to the magnetic oxygenated zirconium biological ceramics of the bulk obtained: ultimate compression strength 1220MPa; Toughness 20MPam
1/2; Young's modulus 135GPa.
To the above-mentioned explanation of the disclosed embodiments, professional and technical personnel in the field are realized or uses the present invention.To be apparent for those skilled in the art to the multiple amendment of these embodiments, General Principle as defined herein can without departing from the spirit or scope of the present invention, realize in other embodiments.Therefore, the present invention can not be restricted to these embodiments shown in this article, but will meet the widest scope consistent with principle disclosed herein and features of novelty.
Claims (6)
1. a magnetic oxygenated zirconium biological ceramics, is characterized in that, is prepared from by each component of following mass fraction:
Nano zircite 65.0-85.0 part, nano aluminium oxide 12.0-22.0 part, calcium phosphate 5.5-9.5 part, nickel powder 2.5-5.0 part, ultra-fine Z 250 3.0-6.0 part, pure aluminium silicate 2.0-5.0 part, zinc oxide 1.0-3.0 part and platinum powder 0.5-1.0 part.
2. magnetic oxygenated zirconium biological ceramics according to claim 1, it is characterized in that, described biological ceramics is prepared from by each component of following mass fraction: nano zircite 69.0-77.0 part, nano aluminium oxide 15.0-21.0 part, calcium phosphate 6.5-8.5 part, nickel powder 2.8-3.5 part, ultra-fine Z 250 4.5-5.5 part, pure aluminium silicate 3.0-4.0 part, zinc oxide 1.5-2.5 part and platinum powder 0.6-0.8 part.
3. magnetic oxygenated zirconium biological ceramics according to claim 2, is characterized in that: described biological ceramics is prepared from by each component of following mass fraction: nano zircite 73.0 parts, nano aluminium oxide 16.0 parts, calcium phosphate 7.5, part, nickel powder 3.2 parts, ultra-fine Z 250 5.3 parts, pure aluminium silicate 3.6 parts, 1.8 parts, zinc oxide and 0.7 part, platinum powder.
4. a preparation method for magnetic oxygenated zirconium biological ceramics according to claim 1, it is characterized in that, preparation process is as follows:
(1) get the raw materials ready: accurately take each component;
(2) prepare Preblend: each component mixed, put into grinding machine and grind, obtain Preblend;
(3) high-temperature calcination: mould is put in Preblend prepared by step (2), carry out high-temperature calcination under argon shield, temperature is 1220 DEG C-1350 DEG C, pressure 500-800MPa, time 2-5h;
(4) step cooling: after calcining, enters distribution cooling stages, the first stage, and temperature is dropped to 850 DEG C-900 DEG C, pressure remains unchanged, and continues 2h; Subordinate phase, temperature drops to 550 DEG C-600 DEG C further, and pressure progressively drops to 200-300MPa, time length 3h; Phase III, temperature is down to 350 DEG C-380 DEG C, Pressure Drop to 0, time length 5h; Final stage, naturally cooling;
(5) taking-up to be cooled, namely obtains block magnetic oxygenated zirconium biological ceramics.
5. the preparation method of magnetic oxygenated zirconium biological ceramics according to claim 4, is characterized in that: in step (3), the temperature of high-temperature calcination is 1280 DEG C.
6. the preparation method of magnetic oxygenated zirconium biological ceramics according to claim 4, is characterized in that: in step (3), the pressure of high-temperature calcination is 680MPa.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510635449.XA CN105274416A (en) | 2015-09-30 | 2015-09-30 | Magnetic zirconia biological ceramic and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510635449.XA CN105274416A (en) | 2015-09-30 | 2015-09-30 | Magnetic zirconia biological ceramic and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105274416A true CN105274416A (en) | 2016-01-27 |
Family
ID=55144235
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510635449.XA Pending CN105274416A (en) | 2015-09-30 | 2015-09-30 | Magnetic zirconia biological ceramic and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105274416A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110578067A (en) * | 2019-10-30 | 2019-12-17 | 株洲硬质合金集团有限公司 | Sintering method of superfine hard alloy |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6843943B1 (en) * | 1998-10-02 | 2005-01-18 | Doxa Aktiebolag | Method of producing bioactive composite materials |
| CN104388793A (en) * | 2014-11-14 | 2015-03-04 | 苏州蔻美新材料有限公司 | Medical metal ceramic material and preparation method thereof |
| CN104446432A (en) * | 2014-11-10 | 2015-03-25 | 苏州维泰生物技术有限公司 | Magnetic hydroxyapatite bioceramic and preparation method thereof |
| CN104829229A (en) * | 2015-03-31 | 2015-08-12 | 苏州维泰生物技术有限公司 | Composite artificial bone zirconia biological ceramic and preparation method thereof |
| CN104829228A (en) * | 2015-03-31 | 2015-08-12 | 苏州维泰生物技术有限公司 | Zirconia biological ceramic used for making hip joint and its preparation method |
-
2015
- 2015-09-30 CN CN201510635449.XA patent/CN105274416A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6843943B1 (en) * | 1998-10-02 | 2005-01-18 | Doxa Aktiebolag | Method of producing bioactive composite materials |
| CN104446432A (en) * | 2014-11-10 | 2015-03-25 | 苏州维泰生物技术有限公司 | Magnetic hydroxyapatite bioceramic and preparation method thereof |
| CN104388793A (en) * | 2014-11-14 | 2015-03-04 | 苏州蔻美新材料有限公司 | Medical metal ceramic material and preparation method thereof |
| CN104829229A (en) * | 2015-03-31 | 2015-08-12 | 苏州维泰生物技术有限公司 | Composite artificial bone zirconia biological ceramic and preparation method thereof |
| CN104829228A (en) * | 2015-03-31 | 2015-08-12 | 苏州维泰生物技术有限公司 | Zirconia biological ceramic used for making hip joint and its preparation method |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110578067A (en) * | 2019-10-30 | 2019-12-17 | 株洲硬质合金集团有限公司 | Sintering method of superfine hard alloy |
| CN110578067B (en) * | 2019-10-30 | 2021-08-10 | 株洲硬质合金集团有限公司 | Sintering method of superfine hard alloy |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101942620B1 (en) | Zirconia ceramic dental implants fused with bioactive glass ceramic artificial bone powders | |
| US20210330431A1 (en) | Trabecular porous tantalum dental implant and preparation method thereof | |
| CN103599561A (en) | Preparation method of magnesium alloy/hydroxyapatite composite | |
| CN106830899B (en) | Composite ceramic material and preparation method and application thereof | |
| US20130150227A1 (en) | Composite Bio-Ceramic Dental Implant and Fabricating Method Thereof | |
| CN104446462A (en) | Zirconia biological ceramic and preparation method thereof | |
| CN105349839B (en) | A kind of low elastic modulus β-Zr type biomedical alloys and preparation method thereof | |
| CN102178564A (en) | Oral implant abutment and manufacturing method thereof | |
| WO2020029785A1 (en) | Pre-mixed strontium silicate-based biological hydraulic cementing paste composition, preparation method therefor, and application thereof | |
| CN104803673A (en) | Hydroxyapatite/sodium titanate composite biological ceramic and preparation method thereof | |
| CN102363050A (en) | Medical biological material and preparation method thereof | |
| CN105274416A (en) | Magnetic zirconia biological ceramic and preparation method thereof | |
| CN110384828B (en) | Magnetic magnesium-loaded artificial bone and method for preparing magnetic magnesium-loaded artificial bone by 3D printing | |
| CN106563808B (en) | A kind of passive middle ear implanted device and preparation method thereof | |
| CN104803671A (en) | Tertiary calcium phosphate/zirconia bioceramic and preparation method thereof | |
| CN101816807B (en) | Bone repairing material for personalized treatment | |
| CN102423504A (en) | Piezoelectric calcium phosphate cement composite material | |
| CN104706433B (en) | A kind of porous surface bioactive implant | |
| CN105816917A (en) | High-toughness super-wear-resistance artificial bone for repairing bone defects and preparation method thereof | |
| CN104744026A (en) | Rear-earth doped hydroxyapatite bioactive ceramic and preparation method thereof | |
| CN105218079B (en) | A kind of carbon nanotube/aluminium oxide bioceramic and preparation method thereof | |
| TWI449544B (en) | Hard tissue regeneration material and method for manufacturing the same | |
| CN104042350A (en) | Implant with plasma coated nano-zirconium oxide coating and preparation method thereof | |
| CN101972174B (en) | ZrO2-HA combined oral implant restoration body and manufacturing method thereof | |
| CN104829223A (en) | Tricalcium phosphate/ magnesium oxide composite biological ceramic and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160127 |