CN104803673A - Hydroxyapatite/sodium titanate composite biological ceramic and preparation method thereof - Google Patents

Hydroxyapatite/sodium titanate composite biological ceramic and preparation method thereof Download PDF

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CN104803673A
CN104803673A CN201510146843.7A CN201510146843A CN104803673A CN 104803673 A CN104803673 A CN 104803673A CN 201510146843 A CN201510146843 A CN 201510146843A CN 104803673 A CN104803673 A CN 104803673A
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hydroxyapatite
parts
acid sodium
sodium titanate
preparation
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CN104803673B (en
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潘林根
刘乐峰
郭玉芹
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Foshan Sanshui high-power inorganic material Co. Ltd.
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SUZHOU VIVOTIDE BIOTECHNOLOGIES CO Ltd
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Priority to CN201611012059.8A priority Critical patent/CN106474540A/en
Priority to CN201510146843.7A priority patent/CN104803673B/en
Priority to CN201611012066.8A priority patent/CN106630997A/en
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Abstract

The invention discloses hydroxyapatite/sodium titanate composite biological ceramic and a preparation method thereof, and relates to the field of biological materials. The composite biological ceramic is prepared from the following components in parts by mass: 30-50 parts of hydroxyapatite, 20-40 parts of sodium titanate, 5-10 parts of nanometer titania, 3-7 parts of zirconium oxide, 2-6 parts of boron nitride, 5-10 parts of aluminum oxide and 2-5 parts of nanometer zinc oxide. The invention further discloses a method for preparing the hydroxyapatite/sodium titanate composite biological ceramic. The preparation method includes the following steps: (1) weighing; (2) ball grinding; (3) cold-press molding; (4) high-temperature calcinations; (5) cooling. The hydroxyapatite/sodium titanate composite biological ceramic provided by the invention utilizes the promotion action of sodium titanate on the biological activity of hydroxyapatite and further improves the biological performance of hydroxyapatite; therefore, the hydroxyapatite/sodium titanate composite biological ceramic provided by the invention has better biological activity and is an ideal skeleton repair substitute material.

Description

A kind of hydroxyapatite/Ti acid sodium composite boilogical ceramic and preparation method thereof
Technical field
The invention belongs to technical field of biological material, particularly the preparation method of a kind of hydroxyapatite/Ti acid sodium composite boilogical ceramic and this biological ceramics.
Background technology
Along with the development of material science and technology, the property that biomaterial is repaired body tissue because of it, substituted and regenerate, has become one of important research direction of current biomedical sector.Biological hard tissue substitute material is use body bone, animal bone the earliest, develops into afterwards and adopts stainless steel and plastics, because stainless steel exists dissolved, corrosion and fatigue problem, and the problem that plastics existence and stability is poor and intensity is low.Therefore cause the bottleneck that biomaterial develops, the appearance of biological ceramics, improve the deficiency of existing equivalent material, because of its many advantages, therefore, biological ceramics is provided with vast potential for future development.
Calcium phosphate ceramic (CPC) is the important kind in biological active ceramic material, and what current investigation and application was maximum is hydroxyapatite (HA) and tricalcium phosphate (TCP).Calcium phosphate ceramic contains CaO and P 2o 5two kinds of compositions, be the important inorganic substance forming human body hard tissue, after implant into body, its surface, with the combination of tissue by key, reaches completely affine.Wherein, HA on the Nomenclature Composition and Structure of Complexes with people's bone and tooth closely similar, HA can make osteocyte be attached to its surface, along with the growth of new bone, this connects area atrophy gradually, and HA becomes a part for bone by crystal skin, and new bone can seek connections with growth from HA implant and green bone junction along implant surfaces or internal run-through hole.HA bioactive ceramics is typical bioactive pottery, and interface can form chemical key be combined with being organized in after implanting, have higher mechanical property, in human physiological environment, resolvability is lower.
At present, people are relatively less to the research of sodium titanate, and sodium titanate is also possess one of certain bioactive material, and it develops to some extent at ceramic field, there are some researches show, the biological activity of sodium titanate to hydroxyapatite has promoter action.
Summary of the invention
The technical problem that the present invention solves: for above-mentioned deficiency, overcome the defect of prior art, the object of this invention is to provide a kind of hydroxyapatite/Ti acid sodium composite boilogical ceramic and preparation method thereof.
Technical scheme of the present invention: a kind of hydroxyapatite/Ti acid sodium composite boilogical ceramic, is prepared from by each component of following mass fraction:
Hydroxyapatite 30-50 part, sodium titanate 20-40 part, nano-titanium oxide 5-10 part, zirconium white 3-7 part, boron nitride 2-6 part, aluminum oxide 5-10 part and nano zine oxide 2-5 part.
As preferably, the mass fraction of each component is: hydroxyapatite 35-45 part, sodium titanate 25-36 part, nano-titanium oxide 6-9 part, zirconium white 4-6 part, boron nitride 3-5 part, aluminum oxide 6-8 part and nano zine oxide 3-4 part.
As preferably, the mass fraction of each component is: hydroxyapatite 42 parts, sodium titanate 34 parts, nano-titanium oxide 8 parts, zirconium white 5 parts, boron nitride 4 parts, 7 parts, aluminum oxide and nano zine oxide 3 parts.
A preparation method for hydroxyapatite/Ti acid sodium composite boilogical ceramic, preparation process is as follows:
(1) weigh: accurately take each component;
(2) ball milling: each component mixed, puts into ball mill and carries out ground and mixed;
(3) coldmoulding: mixed powder is carried out coldmoulding;
(4) powder after shaping is put into mould, carry out high-temperature calcination, temperature is 1000 DEG C-1400 DEG C, pressure 300-800MPa, time 3-10h;
(5), after calcining, taking-up to be cooled, namely obtains block hydroxyapatite/Ti acid sodium composite boilogical ceramic.
As preferably, in step (4), the temperature of calcining is 1150 DEG C.
As preferably, in step (4), the pressure of calcining is 600MPa.
Beneficial effect: hydroxyapatite/Ti acid sodium composite boilogical ceramic provided by the invention, is utilize sodium titanate to the promoter action of hydroxyapatite bioactive, improves the biological property of hydroxyapatite further.Sodium titanate and hydroxyapatite are after high-temperature calcination, sodium titanate form changes, containing calcium ion among sodium titanate layer, the deposition of the sodium titanate layer containing calcium ion to hydroxyapatite has higher incentive, more promotes the formation of hydroxyapatite in human body.
Therefore, hydroxyapatite/Ti acid sodium composite boilogical ceramic provided by the invention has good biological activity, is a kind of desirable bone repair equivalent material.
Embodiment
In order to understand the present invention further, below in conjunction with embodiment, the preferred embodiment of the invention is described, but should be appreciated that these describe just for further illustrating the features and advantages of the present invention, instead of limiting to the claimed invention.
Embodiment 1:
A kind of hydroxyapatite/Ti acid sodium composite boilogical ceramic, comprises each component of following mass fraction:
Hydroxyapatite 50 parts, sodium titanate 40 parts, nano-titanium oxide 10 parts, zirconium white 7 parts, boron nitride 6 parts, 10 parts, aluminum oxide and nano zine oxide 5 parts.
Prepare hydroxyapatite/Ti acid sodium composite boilogical ceramic according to preparation method provided by the invention, step is as follows:
(1) weigh: accurately take each component;
(2) ball milling: each component mixed, puts into ball mill and carries out ground and mixed;
(3) coldmoulding: adopted by mixed powder 60T press to suppress;
(4) powder after shaping is put into mould, carry out high-temperature calcination, temperature is 1300 DEG C, pressure 700MPa, time 4h;
(5), after calcining, taking-up to be cooled, namely obtains block hydroxyapatite/Ti acid sodium composite boilogical ceramic.
The block hydroxyapatite/Ti acid sodium composite boilogical ceramic obtained is detected, detects the performance of biological ceramics: hardness 840HV; Compressive strength 1100MPa; Bending strength 420MPa; Toughness 16MPam 1/2.
Embodiment 2:
A kind of hydroxyapatite/Ti acid sodium composite boilogical ceramic, comprises each component of following mass fraction:
Hydroxyapatite 30 parts, sodium titanate 20 parts, nano-titanium oxide 5 parts, zirconium white 3 parts, boron nitride 2 parts, 5 parts, aluminum oxide and nano zine oxide 2 parts.
Prepare hydroxyapatite/Ti acid sodium composite boilogical ceramic according to preparation method provided by the invention, step is as follows:
(1) weigh: accurately take each component;
(2) ball milling: each component mixed, puts into ball mill and carries out ground and mixed;
(3) coldmoulding: adopted by mixed powder 60T press to suppress;
(4) powder after shaping is put into mould, carry out high-temperature calcination, temperature is 1300 DEG C, pressure 700MPa, time 7h;
(5), after calcining, taking-up to be cooled, namely obtains block hydroxyapatite/Ti acid sodium composite boilogical ceramic.
The block hydroxyapatite/Ti acid sodium composite boilogical ceramic obtained is detected, detects the performance of biological ceramics: hardness 810HV; Compressive strength 1060MPa; Bending strength 400MPa; Toughness 14MPam 1/2.
Embodiment 3:
A kind of hydroxyapatite/Ti acid sodium composite boilogical ceramic, comprises each component of following mass fraction:
Hydroxyapatite 35 parts, sodium titanate 25 parts, nano-titanium oxide 6 parts, zirconium white 4 parts, boron nitride 3 parts, 6 parts, aluminum oxide and nano zine oxide 3 parts.
Prepare hydroxyapatite/Ti acid sodium composite boilogical ceramic according to preparation method provided by the invention, step is as follows:
(1) weigh: accurately take each component;
(2) ball milling: each component mixed, puts into ball mill and carries out ground and mixed;
(3) coldmoulding: adopted by mixed powder 60T press to suppress;
(4) powder after shaping is put into mould, carry out high-temperature calcination, temperature is 1150 DEG C, pressure 600MPa, time 6h;
(5), after calcining, taking-up to be cooled, namely obtains block hydroxyapatite/Ti acid sodium composite boilogical ceramic.
The block hydroxyapatite/Ti acid sodium composite boilogical ceramic obtained is detected, detects the performance of biological ceramics: hardness 810HV; Compressive strength 1060MPa; Bending strength 400MPa; Toughness 14MPam 1/2.
Embodiment 4:
A kind of hydroxyapatite/Ti acid sodium composite boilogical ceramic, comprises each component of following mass fraction:
Hydroxyapatite 45 parts, sodium titanate 36 parts, nano-titanium oxide 9 parts, zirconium white 6 parts, boron nitride 5 parts, 8 parts, aluminum oxide and nano zine oxide 4 parts.
Prepare hydroxyapatite/Ti acid sodium composite boilogical ceramic according to preparation method provided by the invention, step is as follows:
(1) weigh: accurately take each component;
(2) ball milling: each component mixed, puts into ball mill and carries out ground and mixed;
(3) coldmoulding: adopted by mixed powder 60T press to suppress;
(4) powder after shaping is put into mould, carry out high-temperature calcination, temperature is 1150 DEG C, pressure 600MPa, time 6h;
(5), after calcining, taking-up to be cooled, namely obtains block hydroxyapatite/Ti acid sodium composite boilogical ceramic.
The block hydroxyapatite/Ti acid sodium composite boilogical ceramic obtained is detected, detects the performance of biological ceramics: hardness 820HV; Compressive strength 1080MPa; Bending strength 410MPa; Toughness 16MPam 1/2.
Embodiment 5:
A kind of hydroxyapatite/Ti acid sodium composite boilogical ceramic, comprises each component of following mass fraction:
Hydroxyapatite 42 parts, sodium titanate 34 parts, nano-titanium oxide 8 parts, zirconium white 5 parts, boron nitride 4 parts, 7 parts, aluminum oxide and nano zine oxide 3 parts.
Prepare hydroxyapatite/Ti acid sodium composite boilogical ceramic according to preparation method provided by the invention, step is as follows:
(1) weigh: accurately take each component;
(2) ball milling: each component mixed, puts into ball mill and carries out ground and mixed;
(3) coldmoulding: adopted by mixed powder 60T press to suppress;
(4) powder after shaping is put into mould, carry out high-temperature calcination, temperature is 1150 DEG C, pressure 600MPa, time 5h;
(5), after calcining, taking-up to be cooled, namely obtains block hydroxyapatite/Ti acid sodium composite boilogical ceramic.
The block hydroxyapatite/Ti acid sodium composite boilogical ceramic obtained is detected, detects the performance of biological ceramics: hardness 820HV; Compressive strength 1080MPa; Bending strength 420MPa; Toughness 16MPam 1/2.
To the above-mentioned explanation of the disclosed embodiments, professional and technical personnel in the field are realized or uses the present invention.To be apparent for those skilled in the art to the multiple amendment of these embodiments, General Principle as defined herein can without departing from the spirit or scope of the present invention, realize in other embodiments.Therefore, the present invention can not be restricted to these embodiments shown in this article, but will meet the widest scope consistent with principle disclosed herein and features of novelty.

Claims (6)

1. a hydroxyapatite/Ti acid sodium composite boilogical ceramic, is characterized in that, be prepared from by each component of following mass fraction:
Hydroxyapatite 30-50 part, sodium titanate 20-40 part, nano-titanium oxide 5-10 part, zirconium white 3-7 part, boron nitride 2-6 part, aluminum oxide 5-10 part and nano zine oxide 2-5 part.
2. hydroxyapatite/Ti acid sodium composite boilogical ceramic according to claim 1, is characterized in that: the mass fraction of each component is: hydroxyapatite 35-45 part, sodium titanate 25-36 part, nano-titanium oxide 6-9 part, zirconium white 4-6 part, boron nitride 3-5 part, aluminum oxide 6-8 part and nano zine oxide 3-4 part.
3. hydroxyapatite/Ti acid sodium composite boilogical ceramic according to claim 2, is characterized in that: the mass fraction of each component is: hydroxyapatite 42 parts, sodium titanate 34 parts, nano-titanium oxide 8 parts, zirconium white 5 parts, boron nitride 4 parts, 7 parts, aluminum oxide and nano zine oxide 3 parts.
4. a preparation method for hydroxyapatite/Ti acid sodium composite boilogical ceramic according to claim 1, it is characterized in that, preparation process is as follows:
(1) weigh: accurately take each component;
(2) ball milling: each component mixed, puts into ball mill and carries out ground and mixed;
(3) coldmoulding: mixed powder is carried out coldmoulding;
(4) powder after shaping is put into mould, carry out high-temperature calcination, temperature is 1000 DEG C-1400 DEG C, pressure 300-800MPa, time 3-10h;
(5), after calcining, taking-up to be cooled, namely obtains block hydroxyapatite/Ti acid sodium composite boilogical ceramic.
5. the preparation method of hydroxyapatite/Ti acid sodium composite boilogical ceramic according to claim 4, is characterized in that: in step (4), the temperature of calcining is 1150 DEG C.
6. the preparation method of hydroxyapatite/Ti acid sodium composite boilogical ceramic according to claim 4, is characterized in that: in step (4), the pressure of calcining is 600MPa.
CN201510146843.7A 2015-03-31 2015-03-31 A kind of hydroxyapatite/Ti acid sodium composite boilogical ceramic and preparation method thereof Expired - Fee Related CN104803673B (en)

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