CN104803673B - A kind of hydroxyapatite/Ti acid sodium composite boilogical ceramic and preparation method thereof - Google Patents

A kind of hydroxyapatite/Ti acid sodium composite boilogical ceramic and preparation method thereof Download PDF

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CN104803673B
CN104803673B CN201510146843.7A CN201510146843A CN104803673B CN 104803673 B CN104803673 B CN 104803673B CN 201510146843 A CN201510146843 A CN 201510146843A CN 104803673 B CN104803673 B CN 104803673B
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hydroxyapatite
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acid sodium
composite boilogical
boilogical ceramic
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CN104803673A (en
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彭云送
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Foshan Sanshui high-power inorganic material Co. Ltd.
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Foshan Sanshui High-Power Inorganic Material Co Ltd
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Priority to CN201611012066.8A priority patent/CN106630997A/en
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Abstract

The invention discloses a kind of hydroxyapatite/Ti acid sodium composite boilogical ceramic and preparation method thereof, it is related to technical field of biological material, is prepared from by each component of following mass fraction：30 50 parts of hydroxyapatite, 20 40 parts of sodium titanate, 5 10 parts of nano-titanium oxide, 37 parts of zirconium oxide, 26 parts of boron nitride, 5 10 parts of aluminium oxide and 25 parts of nano zine oxide.A kind of preparation method of hydroxyapatite/Ti acid sodium composite boilogical ceramic, preparation process is as follows：（1）Weigh；（2）Ball milling；（3）Cold moudling；（4）High-temperature calcination；（5）Cooling.The hydroxyapatite/Ti acid sodium composite boilogical ceramic that the present invention provides, is the facilitation using sodium titanate to hydroxyapatite bioactive, improves the biological property of hydroxyapatite further.Therefore, the hydroxyapatite/Ti acid sodium composite boilogical ceramic that the present invention provides has preferable biological activity, is a kind of preferable bone repair substitution material.

Description

A kind of hydroxyapatite/Ti acid sodium composite boilogical ceramic and preparation method thereof
Technical field
The invention belongs to technical field of biological material, particularly to a kind of hydroxyapatite/Ti acid sodium composite boilogical ceramic and should The preparation method of bioceramic.
Background technology
With the development of material science and technology, the particularity that biomaterial is repaired to body tissue, substituted and regenerated because of it Can, have become as one of important research direction of current biomedical sector.Biological hard tissue substitute material is to use body earliest Bone, animal bone, developed into later using rustless steel and plastics, because rustless steel has dissolved, corrosion and fatigue problem, plastics are deposited Problem in stability difference and low intensity.Thus result in the bottleneck of biomaterial development, the appearance of bioceramic, improve existing The deficiency of substitution material, because of its many advantages, therefore, bioceramic is provided with vast potential for future development.
Calcium phosphate ceramic (CPC) is the important species in biological active ceramic material, studies at present and application is most is Hydroxyapatite (HA) and tricalcium phosphate (TCP).Calcium phosphate ceramic contains CaO and P2O5Two kinds of compositions, are to constitute human body hard tissue Important inorganic substances, implantation human body after, its surface can reach completely affine by the combination of key with tissue.Wherein, HA Closely similar with people's bone and tooth on the Nomenclature Composition and Structure of Complexes, HA can make osteocyte be attached to its surface, with the growth of new bone, This connects area gradually atrophy, and HA becomes a part for bone by crystal outer layer, new bone can from HA implant and Growth is sought connections with along implant surfaces or internal run-through hole in green bone junction.HA bioactive ceramicses are typical bioactive Pottery, can be combined with being organized in the chemical key of formation on interface after implanting, have higher mechanical property, in Human Physiology In environment, resolvability is relatively low.
At present, people are relatively fewer to the research of sodium titanate, and sodium titanate is also to possess one of material of certain biological activity, It has developed in ceramic field, there are some researches show, sodium titanate has promotion and makees to the biological activity of hydroxyapatite With.
Content of the invention
Present invention solves the technical problem that：For above-mentioned deficiency, overcome the defect of prior art, the purpose of the present invention is to carry For a kind of hydroxyapatite/Ti acid sodium composite boilogical ceramic and preparation method thereof.
Technical scheme：A kind of hydroxyapatite/Ti acid sodium composite boilogical ceramic, each by following mass fraction Individual component is prepared from：
Hydroxyapatite 30-50 part, sodium titanate 20-40 part, nano-titanium oxide 5-10 part, zirconium oxide 3-7 part, boron nitride 2- 6 parts, aluminium oxide 5-10 part and nano zine oxide 2-5 part.
Preferably, the mass fraction of each component is：Hydroxyapatite 35-45 part, sodium titanate 25-36 part, nano oxygen Change titanium 6-9 part, zirconium oxide 4-6 part, boron nitride 3-5 part, aluminium oxide 6-8 part and nano zine oxide 3-4 part.
Preferably, the mass fraction of each component is：42 parts of hydroxyapatite, 34 parts of sodium titanate, nano-titanium oxide 8 Part, 5 parts of zirconium oxide, 4 parts of boron nitride, 7 parts of aluminium oxide and 3 parts of nano zine oxide.
A kind of preparation method of hydroxyapatite/Ti acid sodium composite boilogical ceramic, preparation process is as follows：
（1）Weigh：Accurately weigh each component；
（2）Ball milling：Each component is mixed, puts into ball mill and be ground mixing；
（3）Cold moudling：Mixed powder is carried out cold moudling；
（4）Put into after powder body molding in mould, carry out high-temperature calcination, temperature is 1000 DEG C -1400 DEG C, pressure 300- 800MPa, time 3-10h；
（5）After calcining, taking-up to be cooled, that is, obtain block hydroxyapatite/Ti acid sodium composite boilogical ceramic.
Preferably, step（4）The temperature of middle calcining is 1150 DEG C.
Preferably, step（4）The pressure of middle calcining is 600MPa.
Beneficial effect：The hydroxyapatite/Ti acid sodium composite boilogical ceramic that the present invention provides, is to hydroxyl using sodium titanate The facilitation of apatite biological activity, improves the biological property of hydroxyapatite further.Sodium titanate and hydroxyapatite warp After high-temperature calcination, sodium titanate form generation changes, and contains calcium ion, the sodium titanate layer containing calcium ion among sodium titanate layer To the deposition of hydroxyapatite, there is higher allure, more promote the formation of hydroxyapatite in human body.
Therefore, the hydroxyapatite/Ti acid sodium composite boilogical ceramic that the present invention provides has preferable biological activity, is one Plant preferable bone repair substitution material.
Specific embodiment
For a further understanding of the present invention, with reference to embodiment, the preferred embodiment of the invention is described, but It should be appreciated that these descriptions are simply to further illustrate the features and advantages of the present invention, rather than to the claims in the present invention Limit.
Embodiment 1：
A kind of hydroxyapatite/Ti acid sodium composite boilogical ceramic, including each component of following mass fraction：
50 parts of hydroxyapatite, 40 parts of sodium titanate, 10 parts of nano-titanium oxide, 7 parts of zirconium oxide, 6 parts of boron nitride, aluminium oxide 10 Part and 5 parts of nano zine oxide.
Hydroxyapatite/Ti acid sodium composite boilogical ceramic is prepared according to the preparation method that the present invention provides, step is as follows：
（1）Weigh：Accurately weigh each component；
（2）Ball milling：Each component is mixed, puts into ball mill and be ground mixing；
（3）Cold moudling：Mixed powder is suppressed using 60T press；
（4）Put into after powder body molding in mould, carry out high-temperature calcination, temperature is 1300 DEG C, pressure 700MPa, time 4h；
（5）After calcining, taking-up to be cooled, that is, obtain block hydroxyapatite/Ti acid sodium composite boilogical ceramic.
The block hydroxyapatite/Ti acid sodium composite boilogical ceramic obtaining is detected, the performance of detection bioceramic： Hardness 840HV；Compressive strength 1100MPa；Bending strength 420MPa；Toughness 16MPa m1/2.
Embodiment 2：
A kind of hydroxyapatite/Ti acid sodium composite boilogical ceramic, including each component of following mass fraction：
30 parts of hydroxyapatite, 20 parts of sodium titanate, 5 parts of nano-titanium oxide, 3 parts of zirconium oxide, 2 parts of boron nitride, 5 parts of aluminium oxide With 2 parts of nano zine oxide.
Hydroxyapatite/Ti acid sodium composite boilogical ceramic is prepared according to the preparation method that the present invention provides, step is as follows：
（1）Weigh：Accurately weigh each component；
（2）Ball milling：Each component is mixed, puts into ball mill and be ground mixing；
（3）Cold moudling：Mixed powder is suppressed using 60T press；
（4）Put into after powder body molding in mould, carry out high-temperature calcination, temperature is 1300 DEG C, pressure 700MPa, time 7h；
（5）After calcining, taking-up to be cooled, that is, obtain block hydroxyapatite/Ti acid sodium composite boilogical ceramic.
The block hydroxyapatite/Ti acid sodium composite boilogical ceramic obtaining is detected, the performance of detection bioceramic： Hardness 810HV；Compressive strength 1060MPa；Bending strength 400MPa；Toughness 14MPa m1/2.
Embodiment 3：
A kind of hydroxyapatite/Ti acid sodium composite boilogical ceramic, including each component of following mass fraction：
35 parts of hydroxyapatite, 25 parts of sodium titanate, 6 parts of nano-titanium oxide, 4 parts of zirconium oxide, 3 parts of boron nitride, 6 parts of aluminium oxide With 3 parts of nano zine oxide.
Hydroxyapatite/Ti acid sodium composite boilogical ceramic is prepared according to the preparation method that the present invention provides, step is as follows：
（1）Weigh：Accurately weigh each component；
（2）Ball milling：Each component is mixed, puts into ball mill and be ground mixing；
（3）Cold moudling：Mixed powder is suppressed using 60T press；
（4）Put into after powder body molding in mould, carry out high-temperature calcination, temperature is 1150 DEG C, pressure 600MPa, time 6h；
（5）After calcining, taking-up to be cooled, that is, obtain block hydroxyapatite/Ti acid sodium composite boilogical ceramic.
The block hydroxyapatite/Ti acid sodium composite boilogical ceramic obtaining is detected, the performance of detection bioceramic： Hardness 810HV；Compressive strength 1060MPa；Bending strength 400MPa；Toughness 14MPa m1/2.
Embodiment 4：
A kind of hydroxyapatite/Ti acid sodium composite boilogical ceramic, including each component of following mass fraction：
45 parts of hydroxyapatite, 36 parts of sodium titanate, 9 parts of nano-titanium oxide, 6 parts of zirconium oxide, 5 parts of boron nitride, 8 parts of aluminium oxide With 4 parts of nano zine oxide.
Hydroxyapatite/Ti acid sodium composite boilogical ceramic is prepared according to the preparation method that the present invention provides, step is as follows：
（1）Weigh：Accurately weigh each component；
（2）Ball milling：Each component is mixed, puts into ball mill and be ground mixing；
（3）Cold moudling：Mixed powder is suppressed using 60T press；
（4）Put into after powder body molding in mould, carry out high-temperature calcination, temperature is 1150 DEG C, pressure 600MPa, time 6h；
（5）After calcining, taking-up to be cooled, that is, obtain block hydroxyapatite/Ti acid sodium composite boilogical ceramic.
The block hydroxyapatite/Ti acid sodium composite boilogical ceramic obtaining is detected, the performance of detection bioceramic： Hardness 820HV；Compressive strength 1080MPa；Bending strength 410MPa；Toughness 16MPa m1/2.
Embodiment 5：
A kind of hydroxyapatite/Ti acid sodium composite boilogical ceramic, including each component of following mass fraction：
42 parts of hydroxyapatite, 34 parts of sodium titanate, 8 parts of nano-titanium oxide, 5 parts of zirconium oxide, 4 parts of boron nitride, 7 parts of aluminium oxide With 3 parts of nano zine oxide.
Hydroxyapatite/Ti acid sodium composite boilogical ceramic is prepared according to the preparation method that the present invention provides, step is as follows：
（1）Weigh：Accurately weigh each component；
（2）Ball milling：Each component is mixed, puts into ball mill and be ground mixing；
（3）Cold moudling：Mixed powder is suppressed using 60T press；
（4）Put into after powder body molding in mould, carry out high-temperature calcination, temperature is 1150 DEG C, pressure 600MPa, time 5h；
（5）After calcining, taking-up to be cooled, that is, obtain block hydroxyapatite/Ti acid sodium composite boilogical ceramic.
The block hydroxyapatite/Ti acid sodium composite boilogical ceramic obtaining is detected, the performance of detection bioceramic： Hardness 820HV；Compressive strength 1080MPa；Bending strength 420MPa；Toughness 16MPa m1/2.
Described above to the disclosed embodiments, makes professional and technical personnel in the field be capable of or uses the present invention. Multiple modifications to these embodiments will be apparent from for those skilled in the art, as defined herein General Principle can be realized without departing from the spirit or scope of the present invention in other embodiments.Therefore, the present invention It is not intended to be limited to the embodiments shown herein, and be to fit to and principles disclosed herein and features of novelty phase one The scope the widest causing.

Claims (6)

1. a kind of hydroxyapatite/Ti acid sodium composite boilogical ceramic is it is characterised in that each component system by following mass fraction Standby form：
Hydroxyapatite 30-50 part, sodium titanate 20-40 part, nano-titanium oxide 5-10 part, zirconium oxide 3-7 part, boron nitride 2-6 part, Aluminium oxide 5-10 part and nano zine oxide 2-5 part.
2. hydroxyapatite/Ti according to claim 1 acid sodium composite boilogical ceramic it is characterised in that：Each component Mass fraction is：Hydroxyapatite 35-45 part, sodium titanate 25-36 part, nano-titanium oxide 6-9 part, zirconium oxide 4-6 part, boron nitride 3-5 part, aluminium oxide 6-8 part and nano zine oxide 3-4 part.
3. hydroxyapatite/Ti according to claim 2 acid sodium composite boilogical ceramic it is characterised in that：Each component Mass fraction is：42 parts of hydroxyapatite, 34 parts of sodium titanate, 8 parts of nano-titanium oxide, 5 parts of zirconium oxide, 4 parts of boron nitride, aluminium oxide 7 parts and 3 parts of nano zine oxide.
4. a kind of preparation method of hydroxyapatite/Ti acid sodium composite boilogical ceramic according to claim 1, its feature exists In preparation process is as follows：
（1）Weigh：Accurately weigh each component；
（2）Ball milling：Each component is mixed, puts into ball mill and be ground mixing；
（3）Cold moudling：Mixed powder is carried out cold moudling；
（4）Put into after powder body molding in mould, carry out high-temperature calcination, temperature is 1000 DEG C -1400 DEG C, pressure 300-800MPa, Time 3-10h；
（5）After calcining, taking-up to be cooled, that is, obtain block hydroxyapatite/Ti acid sodium composite boilogical ceramic.
5. hydroxyapatite/Ti according to claim 4 acid sodium composite boilogical ceramic preparation method it is characterised in that： Step（4）The temperature of middle calcining is 1150 DEG C.
6. hydroxyapatite/Ti according to claim 4 acid sodium composite boilogical ceramic preparation method it is characterised in that： Step（4）The pressure of middle calcining is 600MPa.
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