CN105267136A - Toothpaste with inactivation lactobacillus salivarius and process for manufacturing toothpaste - Google Patents
Toothpaste with inactivation lactobacillus salivarius and process for manufacturing toothpaste Download PDFInfo
- Publication number
- CN105267136A CN105267136A CN201510801476.XA CN201510801476A CN105267136A CN 105267136 A CN105267136 A CN 105267136A CN 201510801476 A CN201510801476 A CN 201510801476A CN 105267136 A CN105267136 A CN 105267136A
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- CN
- China
- Prior art keywords
- toothpaste
- lactobacillus salivarius
- deactivation lactobacillus
- creme
- pot
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
The invention discloses toothpaste with inactivation lactobacillus salivarius and a process for manufacturing the toothpaste, and belongs to the field of oral nursing articles. The toothpaste and the process have the advantages that the inactivation lactobacillus salivarius is added into the toothpaste, tooth adhesion competition effects can be realized by thalli and harmful streptococcus mutans under the actions of molecules, which are used as media, on the surfaces of the thalli, accordingly, the quantities of the streptococcus mutans adhered on the surfaces of the teeth of users can be reduced, and acidic metabolite which can damage the tooth enamel of the users can be reduced; the toothpaste is manufactured by the aid of formulas and the process including feeding, grinding, vacuum degassing, aging and the like, each 1 g of the toothpaste contains more than 1 mg of the inactivation lactobacillus salivarius, accordingly, effects of preventing tooth decay and resisting inflammation can be effectively realized, and obvious effects can be realized by the toothpaste for preventing the tooth decay.
Description
Technical field
The present invention relates to a kind of toothpaste, the toothpaste specifically containing deactivation Lactobacillus salivarius and preparation technology thereof, belong to oral care implement and processing technique field thereof.
Background technology
Dental caries is the main commonly encountered diseases in oral cavity, is also one of the most general disease of the mankind, and world health group good general itself and tumor and cardiovascular disease are listed as the large keypoint control disease of the mankind three.Being commonly called as dental caries, decayed tooth, is bacterial disease, can secondary pulpitis and periapical periodontitis, even can cause alveolar bone and inflammation of jaws.Streptococcus mutans (Streptococcusmutans) is one of main bacteria causing dental caries.Streptococcus mutans can make carbohydrate breakdown produce acid, causes the demineralization of tooth inanimate matter.Prevent in the market to decay tooth, the toothpaste of antiinflammatory action mostly is product containing Chinese herbal medicine, its effect cannot satisfy the demands.
Summary of the invention
The object of this invention is to provide a kind of toothpaste and the preparation technology thereof that contain Lactobacillus salivarius, utilize bacterial strain and other harmful microbe Competitions, suppress harmful microbe quantity in oral cavity, reduce the generation of acidic metabolite, to reach the effect of anti-decayed tooth, antiinflammatory and anti-tooth Gingival inflammation.
The present invention is achieved through the following technical solutions: a kind of toothpaste containing deactivation Lactobacillus salivarius, and its formula is by following percentage by weight composition: calcium carbonate 20%, sorbitol 15%, glycerol 25%, silica 1 5%, sodium lauryl sulfate 2%, deactivation Lactobacillus salivarius CECT57130.01%-0.5%, essence 1%, saccharin sodium 0.1%, methyl hydroxybenzoate sodium (antiseptic), stannous chloride (stabilizing agent), pigment, pure water; The deactivation Lactobacillus salivarius being not less than 1mg is contained by the every 1g toothpaste of described formula.
The preparation technology of the described toothpaste containing deactivation Lactobacillus salivarius, its technological process is as follows:
(1) cream process processed: according to technical recipe, essence, sodium lauryl sulfate, stannous chloride, methyl hydroxybenzoate sodium, saccharin sodium is complete by dissolved in purified water in pre-molten pot or premix pot, and stir, be added to cream pot processed, then glycerol is added cream pot processed to stir, then add calcium carbonate, sorbitol, silicon dioxide, pigment grind, and makes creme fine and smooth, then add deactivation Lactobacillus salivarius CECT5713, and stirring makes the abundant mix homogeneously of creme; In stirring and process of lapping, the bubble produced in creme is carried out evacuation, and vacuum should reach-0.096MPa, and the time is about 50 minutes; After above-mentioned steps completes, get a small amount of mastic and test, after qualified, then squeeze into mastic and store pot and carry out ageing about 120 minutes, make material naturally cool to room temperature, make material fully expand simultaneously and form the adherend of homogeneous phase, improve the elasticity of material; In above-mentioned cream process processed, because stirring, process of lapping can rub heat release, need use chuck cooling water control temperature≤45 DEG C in summer; The every 1g toothpaste of toothpaste made by described cream process processed contains the deactivation Lactobacillus salivarius being not less than 1mg;
(2) fill, packaging: for creme dress is filled with and finished product packing two-step method; Creme dress is filled on automatic filling line and carries out, and regulates dress filling amount, sealing temperature and speed, and carry out regular check when dress is filled with; Through the follow-up commercial package process of finished product of automatic mounted box, shrink film heat-sealing, vanning after fill completes, shrinkage temperature and speed is regulated during packaging, and check the concordance of the quality and variety of packaging material, prevent blank pipe, sylphon phenomenon, after packaging terminates, stack by kind, chronological classification, test, after qualified, reenter storehouse and store.
The preparation technology of the described toothpaste containing deactivation Lactobacillus salivarius organizes production at normal temperatures.
The preparation technology of the described toothpaste containing deactivation Lactobacillus salivarius stores at normal temperatures and transports.
The preparation technology of the described toothpaste containing deactivation Lactobacillus salivarius packs with flexible pipe, box.
The invention has the beneficial effects as follows: be through batch (-type) deactivation for the Lactobacillus salivarius in toothpaste, its cellularity keeps complete, therefore still remain adhesive capacity, can compete with oral microorganism (Streptococcus mutans), reduce harmful microorganism and gather on tooth, to cause its acidic metabolite produce and dissolve the formation of enamel so that decayed tooth.The toothpaste made by formula of the present invention and preparation technology thereof effectively can play prevention decayed tooth, antiinflammatory action, reduces the generation of dental plaque, for the successful of caries prevention.Bacterial strain is deactivation in addition, does not therefore need the mode considering low tempertaure storage, avoids unnecessary cost.
Detailed description of the invention
Effect of the present invention is further illustrated below in conjunction with embodiment.
Embodiment 1:
The deactivation Lactobacillus salivarius of 1mg is added in 1g toothpaste; Toothpaste is made according to the formula in the present invention and preparation technology thereof, often pipe toothpaste is about 40g, after completing, mastic character is assessed, and detect result of use: after with the addition of deactivation Lactobacillus salivarius in toothpaste, mastic physical behavior does not change with not adding compared with deactivation Lactobacillus salivarius, and deactivation Lactobacillus salivarius does not have an impact to the abnormal smells from the patient of mastic and taste; Through human test, brush teeth at every turn and use about 2g toothpaste, continue 2 weeks, find after off-test, use the toothpaste that with the addition of deactivation Lactobacillus salivarius effectively can reduce the generation of dental plaque.
Embodiment 2:
The deactivation Lactobacillus salivarius of 1.5mg is added in 1g toothpaste; Toothpaste is made according to the formula in the present invention and preparation technology thereof, often pipe toothpaste is about 40g, after completing, mastic character is assessed, and detect result of use: after with the addition of deactivation Lactobacillus salivarius in toothpaste, mastic physical behavior does not change with not adding compared with deactivation Lactobacillus salivarius, and deactivation Lactobacillus salivarius does not have an impact to the abnormal smells from the patient of mastic and taste; Through human test, brush teeth at every turn and use about 2g toothpaste, continue 2 weeks, find after off-test, use the toothpaste that with the addition of deactivation Lactobacillus salivarius effectively can reduce the generation of dental plaque.
Claims (5)
1. the toothpaste containing deactivation Lactobacillus salivarius, its formula is as follows: calcium carbonate 20%, sorbitol 15%, glycerol 25%, silica 1 5%, sodium lauryl sulfate 2%, deactivation Lactobacillus salivarius CECT57130.01%-0.5%, essence 1%, saccharin sodium 0.1%, methyl hydroxybenzoate sodium (antiseptic), stannous chloride (stabilizing agent), pigment, pure water; The every 1g toothpaste of the toothpaste made by described formula contains the deactivation Lactobacillus salivarius being not less than 1mg.
2. a preparation technology for the toothpaste containing deactivation Lactobacillus salivarius according to claim 1, its technique is as follows:
(1) cream process processed: according to technical recipe, essence, sodium lauryl sulfate, stannous chloride, methyl hydroxybenzoate sodium, saccharin sodium is complete by dissolved in purified water in pre-molten pot or premix pot, and stir, be added to cream pot processed, then glycerol is added cream pot processed to stir, then add calcium carbonate, sorbitol, silicon dioxide, pigment grind, and makes creme fine and smooth, then add deactivation Lactobacillus salivarius CECT5713, and stirring makes the abundant mix homogeneously of creme; In stirring and process of lapping, the bubble produced in creme is carried out evacuation, and vacuum should reach-0.096MPa, and the time is about 50 minutes; After above-mentioned steps completes, get a small amount of mastic and test, after qualified, then squeeze into mastic and store pot and carry out ageing about 120 minutes, make material naturally cool to room temperature, make material fully expand simultaneously and form the adherend of homogeneous phase, improve the elasticity of material; In above-mentioned cream process processed, because stirring, process of lapping can rub heat release, need use chuck cooling water control temperature≤45 DEG C in summer; The every 1g toothpaste of toothpaste made by described cream process processed contains the deactivation Lactobacillus salivarius being not less than 1mg;
(2) fill, packaging: for creme dress is filled with and finished product packing two-step method; Creme dress is filled on automatic filling line and carries out, and regulates dress filling amount, sealing temperature and speed, and carry out regular check when dress is filled with; Through the follow-up commercial package process of finished product of automatic mounted box, shrink film heat-sealing, vanning after fill completes, shrinkage temperature and speed is regulated during packaging, and check the concordance of the quality and variety of packaging material, prevent blank pipe, sylphon phenomenon, after packaging terminates, stack by kind, chronological classification, test, after qualified, reenter storehouse and store.
3. the preparation technology of the toothpaste containing deactivation Lactobacillus salivarius according to claim 2: be organize production at normal temperatures.
4. the preparation technology of the toothpaste containing deactivation Lactobacillus salivarius according to claim 2: be store at normal temperatures and transport.
5. the preparation technology of the toothpaste containing deactivation Lactobacillus salivarius according to claim 2: be pack with flexible pipe, box.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510801476.XA CN105267136A (en) | 2015-11-19 | 2015-11-19 | Toothpaste with inactivation lactobacillus salivarius and process for manufacturing toothpaste |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510801476.XA CN105267136A (en) | 2015-11-19 | 2015-11-19 | Toothpaste with inactivation lactobacillus salivarius and process for manufacturing toothpaste |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105267136A true CN105267136A (en) | 2016-01-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510801476.XA Pending CN105267136A (en) | 2015-11-19 | 2015-11-19 | Toothpaste with inactivation lactobacillus salivarius and process for manufacturing toothpaste |
Country Status (1)
| Country | Link |
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| CN (1) | CN105267136A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110559253A (en) * | 2019-09-30 | 2019-12-13 | 曲沃李时珍医药科技有限公司 | toothpaste added with probiotics for resisting oral bacteria and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002234825A (en) * | 2001-02-08 | 2002-08-23 | Nippon Zettoc Co Ltd | Composition for oral cavity application |
| CN102311932A (en) * | 2010-07-07 | 2012-01-11 | 生展生物科技股份有限公司 | Lactobacillus salivarius for improving bacterial population in oral cavity and health-care composition thereof |
-
2015
- 2015-11-19 CN CN201510801476.XA patent/CN105267136A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002234825A (en) * | 2001-02-08 | 2002-08-23 | Nippon Zettoc Co Ltd | Composition for oral cavity application |
| CN102311932A (en) * | 2010-07-07 | 2012-01-11 | 生展生物科技股份有限公司 | Lactobacillus salivarius for improving bacterial population in oral cavity and health-care composition thereof |
Non-Patent Citations (1)
| Title |
|---|
| 常兵等: "牙膏配方", 《日用化学品科学》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110559253A (en) * | 2019-09-30 | 2019-12-13 | 曲沃李时珍医药科技有限公司 | toothpaste added with probiotics for resisting oral bacteria and preparation method thereof |
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Application publication date: 20160127 |