CN105259165B - A kind of agent delivery device of DNA sequencer - Google Patents
A kind of agent delivery device of DNA sequencer Download PDFInfo
- Publication number
- CN105259165B CN105259165B CN201510706066.7A CN201510706066A CN105259165B CN 105259165 B CN105259165 B CN 105259165B CN 201510706066 A CN201510706066 A CN 201510706066A CN 105259165 B CN105259165 B CN 105259165B
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- liquid case
- platform
- plate
- base
- motor
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Abstract
The present invention relates to a kind of agent delivery device of DNA sequencer, including liquid case hoistable platform component, which is the mechanism that pumps that motor leading screw drives；Which includes that motor and motor connect and support the lead screw assembly that the support base of motor and motor connect, the reaction liquid case lifting seat installed in sidepiece, wherein, buffer solution case loading/unloading platform component is equiped with described reaction liquid case lifting seat；Described buffering liquid case loading/unloading platform component is drawing and pulling type structure, and after setting reagent on platform, whole platform assembly when needing to load and unload reagent, platform is pulled out in the casing of right side, and after placing, pushed home is put again.The liquid case hoistable platform component of the present invention is moved reagent delivery to specified location by guide rail, easy to control, accurate；Liquid case hoistable platform rushes gentle for integrated for pump valve tube assembly liquid case loading/unloading platform component and transports up and down, completes reagent conveying, course of reaction.
Description
Technical field
A kind of the present invention relates to DNA sequencing field, more particularly to reagent confession that can be loaded and lift transport DNA sequencer
Answer device.
Background technology
During DNA sequencing, on sequence testing chip, there is chemical reaction, produce visible ray, by CCD (Charge
Couple Device) optical signal produced by cameras capture sequencing reaction, you can the sequencing information required for obtaining.
Agent delivery system provides plurality of reagents in reaction chip, it is desirable to which DNA sequencer can store, defeated as desired
Send, and be convenient for changing reagent；During storage, conveying and changing reagent, it is necessary to convenient control, so as to the examination of supply
Agent is persistently reacted with the sequence testing chip in reaction warehouse, completes sequencing procedure.
In view of drawbacks described above, creator of the present invention passes through prolonged research and practice obtains this creation finally.
Content of the invention
It is an object of the invention to provide a kind of agent delivery device of DNA sequencer, in order to overcome above-mentioned technological deficiency.
For achieving the above object, the present invention provides a kind of agent delivery device of DNA sequencer, including liquid case hoistable platform
Component, its are the mechanism that pumps that motor leading screw drives；Which includes that motor and motor connect and support drive
The lead screw assembly of the support base of dynamic motor and motor connection, the reaction liquid case lifting seat installed in sidepiece, wherein, institute
Buffer solution case loading/unloading platform component is equiped with the reaction liquid case lifting seat that states；
Described buffering liquid case loading/unloading platform component is drawing and pulling type structure, after setting reagent on platform, whole platform group
Part when needing to load and unload reagent, platform is pulled out in the casing of right side, and after placing, pushed home is put again；
Described buffering liquid case loading/unloading platform component includes carrier fluid platform, and which is an arm-tie with handle, and shakes hands
It is fixed on handle plate；The both sides of carrier fluid platform are provided with connecting plate, and the horizontal part of connecting plate is connected with liquid case lifting seat with reaction
Connect；Slide track component is set between described carrier fluid platform and the connecting plate of both sides, which makes carrier fluid platform move along connecting plate.
Further, described reaction liquid case lifting seat includes the intermediate plate being connected with installing plate, is arranged on intermediate plate
The supporting plate of both sides, is provided with horizontal ends on supporting plate, in order to place buffering liquid case loading/unloading platform component.
Further, the output shaft of described motor is connected with leading screw, and leading screw is arranged in base, base and driving
The end of motor is connected by support base；The sidepiece of base is provided with stroke detection switch；
The output shaft of described motor is connected with the connection end of leading screw by shaft coupling；Nut is connected with leading screw,
Nut is fixed on nut seat；Leading screw lower end is provided with bearing (ball) cover by bearings, bearing end.
Further, guide rail is additionally provided with the inside of described base, and reaction liquid case lifting seat is slided installed in guide rail
On block, with slide block movement；Position detection plate is provided with reaction liquid case lifting seat, and position sensing is provided with base
Device, its are arranged in position sensor mounting seat；
Described position sensor mounting seat includes installing plate, arranges thereon and installs screwed hole, is connected with base by screw
Connect；Also include the second detection plate and sensor installing plate, slideway is set in sensor installing plate and the second detection plate, with for institute
The position detection plate mistake that states, carries out location sensitive.
Further, described base, is a frame-type structure, opens up upper leading screw through hole in upper surface, and lower surface opens up down
Bearing supporting wire thick stick is installed in leading screw through hole, two through hole；Be mounting flange in base lower end, its with sequenator on the right side of casing bottom
Holder assembly is connected；Guide rails assembling face is provided with the sidepiece of base, offers guide rails assembling screwed hole thereon.
Further, described slide track component includes the clamp for being fixed on connecting plate sidepiece, with respect to clamp moving and can
The slide plate for stopping, slide plate is coordinated to be fixed on the sidepiece of platform connecting plate with clamp, platform connecting plate is under carrier fluid platform
End, its drive the movement of carrier fluid platform.
Further, slideway is set on described clamp, and slide plate can be moved on slideway；Arrange in the slip of clamp and stop
Only hole, when the projection on slide plate is plugged in stop aperture, slide plate and connected carrier fluid platform stop motion；
Platform connecting plate has identical structure with connecting plate, and when mounted, both reversely install；Its section is wedge shape,
Including an inclined plane and the horizontal plane of sidepiece, horizontal plane is in order to being connected.
Beneficial effects of the present invention are compared with prior art：The liquid of the agent delivery device of the DNA sequencer of the present invention
Case hoistable platform component is moved reagent delivery to specified location by guide rail, easy to control, accurate；Liquid case hoistable platform is by pump
The integrated tube assembly of valve is gentle to rush liquid case loading/unloading platform component and transports up and down, completes reagent conveying, course of reaction.
Using the integrated tube assembly of pump valve, plurality of reagents can be selected simultaneously, and according to the order for pre-setting
Sequencing reaction is carried out, testing efficiency is high.Buffering liquid case loading/unloading platform component, is not only able to the reagent of offer demand, and, handling
Reagent is convenient, saves cabinet space.
Description of the drawings
Fig. 1 is the dimensional structure diagram of the liquid case hoistable platform component of the present invention；
Fig. 2 is the side structure schematic view of the liquid case hoistable platform component of the present invention；
Fig. 3 a are the side structure schematic view of the base of the present invention；
Fig. 3 b are the structural representation of the position sensor mounting seat of the present invention；
Fig. 3 c are the structural representation of the position sensor mounting seat of the present invention；
Fig. 3 d are the structural representation of the support base of the present invention；
Fig. 3 e are the dimensional structure diagram of the nut mounting seat of the present invention；
Fig. 3 f are the dimensional structure diagram of the base of the present invention；
Fig. 4 a are the dimensional structure diagram of the integrated tube assembly of pump valve of the invention；
Fig. 4 b are the backsight structural representation of the integrated tube assembly of pump valve of the invention；
Fig. 4 c are the overlooking the structure diagram of the integrated tube assembly of pump valve of the invention；
Fig. 4 d are the structural representation of the pump valve integrated base plate of the present invention；
Fig. 5 a are the dimensional structure diagram of the buffering liquid case loading/unloading platform component of the present invention；
Fig. 5 b are the positive structure diagram of the buffering liquid case loading/unloading platform component of the present invention；
Fig. 5 c are the structural representation in the guide rail section of the buffering liquid case loading/unloading platform component of the present invention；
Fig. 5 d are the structural representation of the connecting plate of the buffering liquid case loading/unloading platform component of the present invention；
Fig. 5 e are the structural representation of the handle plate of the buffering liquid case loading/unloading platform component of the present invention；
Fig. 5 f are the structural representation of the slideway of the present invention.
Specific embodiment
Below in conjunction with accompanying drawing, above-mentioned He other technical characteristic of the invention and advantage are described in more detail.
The agent delivery device of the DNA sequencer of the present invention, can transmit to relevant position by load reagents and up and down, lead to
Generation chemical reaction during reagent pipeline is transmitted to reaction warehouse is crossed, sequencing procedure is completed.
Refer to shown in Fig. 1 and 2, the agent delivery device of the embodiment of the present invention includes liquid case hoistable platform component, and which is
The mechanism that pumps that motor leading screw drives, which is arranged in the right side casing of sequenator.It include motor 401,
It is connected and supports the lead screw assembly of the support base 402 and motor connection of motor with motor, is arranged on sidepiece
Reaction liquid case lifting seat 408, wherein, is equiped with buffer solution case loading/unloading platform group in described reaction liquid case lifting seat 408
Part, reaction are arranged on the installing plate 404 being connected with reaction liquid case lifting seat, in screw mechanism with liquid case lifting seat 408
Under driving, carry reaction liquid case lifting seat Reagent Tube group and move up and down.
Reaction liquid case lifting seat 408 includes the intermediate plate 4081 being connected with installing plate, is arranged on the support of intermediate plate both sides
Plate 4082, is provided with horizontal ends on supporting plate 4082, in order to place buffering liquid case loading/unloading platform component.
The output shaft of described motor 401 is connected with leading screw 403, and leading screw is arranged in base 405, base 405 with
The end of motor 401 is connected by support base 402；The sidepiece of base 405 is provided with stroke detection switch 406.
The output shaft of described motor is connected with the connection end 4034 of leading screw by shaft coupling 4035；Connect on leading screw
There are nut 4031, nut to be fixed on nut seat 4032；Leading screw lower end is provided with bearing (ball) cover by bearings, bearing end
4011.
The liquid case hoistable platform component of the embodiment of the present invention is moved reagent delivery to specified location, controlling party by guide rail
Just, precisely；Liquid case hoistable platform rushes gentle for integrated for pump valve tube assembly liquid case loading/unloading platform component and transports up and down, completes reagent defeated
Give, course of reaction.
Referring to shown in Fig. 3 a-3f, guide rail 407 being additionally provided with the inside of base, reaction liquid case lifting seat 408 is installed
On guide rail slide block, with slide block movement；Position detection plate 4071 is provided with reaction liquid case lifting seat 408, on base
Position sensor is set, and which is arranged in position sensor mounting seat 4072.Incorporated by reference to shown in Fig. 3 b, which is the position of the present invention
Put the structural representation of sensor installation seat, which includes installing plate 4076, thereon arrange install screwed hole 4077, by screw with
Base connects；Second detection plate 4074, sensor installing plate 4075 are set with the second detection plate 4074 in sensor installing plate 4075
Slideway 4073 is put, with passing through for described position detection plate 4071, location sensitive is carried out.
Refer to shown in Fig. 3 c, the position detection plate of the embodiment of the present invention includes top installing plate 4081, by being arranged on
Screw in screwed hole 4082 is connected with reaction liquid case lifting seat 408；Also include the position detection part 4083 being connected,
In order to mutually to sense with position sensor.
Refer to shown in Fig. 3 d, described support base 402 includes connecting plate for electric motor 4021, and which is connected with motor end face, its
Upper setting connection screw thread hole 4022；The leading screw sleeve 4023 being connected, is provided with locating surface 4024, in leading screw sleeve in order to pacify
Dress leading screw.
Refer to shown in Fig. 3 e, nut mounting seat includes nut mounting surface 4114, lead screw hole 4113 is set thereon, nut is pacified
The surrounding in dress face 4114 arranges trip bolt hole；The mounting surface 4112 being connected with lifting seat installing plate 404 is set in upper surface.
Refer to shown in Fig. 3 f, the base 405 of the embodiment of the present invention is a frame-type structure, opens up upper leading screw in upper surface
Through hole 4051, lower surface are opened up；It is fixation in base lower end
Blue 4053, its with sequenator on the right side of the base assembly of casing be connected；Guide rails assembling is provided with the sidepiece 4052 of base
Face, offers guide rails assembling screwed hole thereon.
The embodiment of the present invention carries out reciprocal transportation using feed screw nut to reagent, and the control accuracy of leading screw disclosure satisfy that examination
The delivery requirements of agent.
Refer to Fig. 4 a-4d to show, the integrated tube assembly of the pump valve of the embodiment of the present invention will examination by the syringe needle suction pipe 507 of downside
Agent is sucked in the Reagent Tube from buffering liquid case loading/unloading platform component, and the selection by fluid path control unit 502, drive control
Valve module 509 and hydraulic pump 506 are selected, and reagent is entered in reagent cartridge, carry out sequencing reaction.
The integrated tube assembly of described pump valve includes that pump valve integrated base plate 508, pump valve integrated base plate 508 include peristaltic pump
The fixed plate 5083 of installing plate 5011 and the connection of peristaltic pump installing plate 5011, base plate 5084, the sipper pore group being arranged on base plate
5085 and base plate in the middle of control valve group part installing plate 5081；Peristaltic pump installation is provided with peristaltic pump installing plate 5011
Hole 5082, arranges two peristaltic pumps 505 thereon；The multiple reagent pipe clamps of interval setting and wire clamp 5015 is gone back on base plate 5084.
Accordingly, mid portion of the control valve group part 509 installed in pump valve integrated base plate 508, hydraulic pump 506 are arranged on
Its sidepiece, arranges fluid path control unit 502 in the other side, and fluid path control unit 502 is by a bending plate 503 and fluid path part
Isolation.
In embodiments of the present invention, the sipper pore group 5085 in order to carry out sequencing reaction to plurality of reagents, on base plate
Multiple holes are arranged side by side, syringe needle suction pipe 507 passes through sipper pore, the other end to connect the fluid path end of Reagent Tube and corresponding control valve
Mouth connection；Pipe clamp 5013 is set on sipper pore, prevents syringe needle suction pipe from inclining.
The embodiment of the present invention, using the integrated tube assembly of pump valve, can be selected to plurality of reagents simultaneously, and according to pre-
The order for first arranging carries out sequencing reaction, and testing efficiency is high.
Refer to shown in Fig. 5 a-5f, buffer structure of the liquid case loading/unloading platform component for drawing and pulling type, on platform, set reagent
Afterwards, whole platform assembly in the casing of right side, when needing to load and unload reagent, platform is pulled out, after placing, is pushed back again
Original position.
Which includes carrier fluid platform 310, and in the present embodiment, which is an arm-tie with handle 3101, and shakes hands to fix
On handle plate 3102；The both sides of carrier fluid platform 310 are provided with connecting plate 311, the horizontal part of connecting plate 311 and reaction liquid case
The supporting plate 4082 of lifting seat 408 connects；In the presence of reaction is with liquid case lifting seat 408, carrier fluid platform 310 moves up to pump
At syringe needle suction pipe 507 on the downside of valve integrated pipe, through the control of control unit, reagent is selectively drawn.
Slide track component 312 is set between described carrier fluid platform 310 and the connecting plate 311 of both sides, which makes carrier fluid platform
Move along connecting plate；Which includes the clamp 315 for being fixed on 311 sidepiece of connecting plate, moves relative to clamp 315 and can match somebody with somebody with clamp
The slide plate for stopping is closed, slide plate is fixed on the sidepiece of platform connecting plate 316, and platform connecting plate 316 is arranged on the lower end of carrier fluid platform,
Which drives the movement of carrier fluid platform.
Refer to shown in Fig. 5 f, slideway 3105 is set on clamp 315, slide plate can be moved on slideway 3105；In clamp 315
Slip 3105 on stop aperture 3104, when the projection on slide plate is plugged in stop aperture 3104, slide plate and connected are set
Carrier fluid platform stop motion.
Platform connecting plate 316 has identical structure with connecting plate 311, and when mounted, both reversely install；Its section is
Wedge shape, including the horizontal plane 3112 of an inclined plane and sidepiece, horizontal plane 3112 is in order to being connected.
The buffering liquid case loading/unloading platform component of the embodiment of the present invention, is not only able to the reagent of offer demand, and, handling examination
Agent is convenient, saves cabinet space.
Above-mentioned detailed description is illustrating for one of them possible embodiments of the present invention, and the embodiment is simultaneously not used to
The scope of the claims of the present invention is limited, all equivalence enforcements or change without departing from carried out by the present invention are intended to be limited solely by the technology of the present invention
In the range of scheme.
Claims (7)
1. the agent delivery device of a kind of DNA sequencer, it is characterised in that including liquid case hoistable platform component, which is motor silk
The mechanism that pumps that thick stick drives；It include motor and motor connect and support the support base of motor,
The lead screw assembly being connected with motor, the reaction liquid case lifting seat for being arranged on sidepiece, wherein, described reaction liquid case liter
Buffer solution case loading/unloading platform component is equiped with drop seat；
Described buffering liquid case loading/unloading platform component is drawing and pulling type structure, after setting reagent on platform, whole platform assembly peace
It is mounted in the casing of right side, when needing to load and unload reagent, platform is pulled out, after placing, pushed home is put again；
Described buffering liquid case loading/unloading platform component includes carrier fluid platform, and which is an arm-tie with handle, and shakes hands to fix
On handle plate；The both sides of carrier fluid platform are provided with connecting plate, and the horizontal part of connecting plate is connected with reaction liquid case lifting seat；?
Slide track component is set between described carrier fluid platform and the connecting plate of both sides, which makes carrier fluid platform move along connecting plate.
2. the agent delivery device of DNA sequencer according to claim 1, it is characterised in that described reaction liquid case
Lifting seat includes the intermediate plate being connected with installing plate, is arranged on the supporting plate of intermediate plate both sides, is provided with horizontal ends on supporting plate, in order to
Place buffering liquid case loading/unloading platform component.
3. the agent delivery device of DNA sequencer according to claim 2, it is characterised in that described motor
Output shaft is connected with leading screw, and leading screw is arranged in base, and base is connected by support base with the end of motor；In base
Sidepiece is provided with stroke detection switch；
The output shaft of described motor is connected with the connection end of leading screw by shaft coupling；Nut, nut is connected with leading screw
It is fixed on nut seat；Leading screw lower end is provided with bearing (ball) cover by bearings, bearing end.
4. the agent delivery device of DNA sequencer according to claim 3, it is characterised in that in described base
Side is additionally provided with guide rail, and reaction is arranged on guide rail slide block, with slide block movement with liquid case lifting seat；In reaction liquid case lifting seat
On be provided with position detection plate, on base arrange position sensor, which is arranged in position sensor mounting seat；
Described position sensor mounting seat includes installing plate, arranges thereon and installs screwed hole, is connected with base by screw；Also
Including the second detection plate and sensor installing plate, slideway is set in sensor installing plate and the second detection plate, with for described
Position detection plate mistake, carries out location sensitive.
5. the agent delivery device of DNA sequencer according to claim 4, it is characterised in that described base, is a frame
Type structure, opens up upper leading screw through hole in upper surface, and lower surface opens up；
Be mounting flange in base lower end, its with sequenator on the right side of the base assembly of casing be connected；Arrange on the sidepiece of base
There is guide rails assembling face, offer guide rails assembling screwed hole thereon.
6. the agent delivery device of DNA sequencer according to claim 1, it is characterised in that described slide track component bag
Include the clamp for being fixed on connecting plate sidepiece, with respect to clamp moving and can with clamp coordinate stop slide plate, slide plate is fixed on flat
The sidepiece of platform connecting plate, installed in the lower end of carrier fluid platform, which drives the movement of carrier fluid platform to platform connecting plate.
7. the agent delivery device of DNA sequencer according to claim 6, it is characterised in that arrange on described clamp
Slideway, slide plate can be moved on slideway；Stop aperture is set in the slip of clamp, and the projection on slide plate is plugged in stop aperture
When, slide plate and connected carrier fluid platform stop motion；
Platform connecting plate has identical structure with connecting plate, and when mounted, both reversely install；Its section is wedge shape, including
One inclined plane and the horizontal plane of sidepiece, horizontal plane is in order to being connected.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510706066.7A CN105259165B (en) | 2015-10-27 | 2015-10-27 | A kind of agent delivery device of DNA sequencer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510706066.7A CN105259165B (en) | 2015-10-27 | 2015-10-27 | A kind of agent delivery device of DNA sequencer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105259165A CN105259165A (en) | 2016-01-20 |
| CN105259165B true CN105259165B (en) | 2017-03-15 |
Family
ID=55098935
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510706066.7A Expired - Fee Related CN105259165B (en) | 2015-10-27 | 2015-10-27 | A kind of agent delivery device of DNA sequencer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105259165B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107916220A (en) * | 2016-10-11 | 2018-04-17 | 广州康昕瑞基因健康科技有限公司 | XY platforms screw drives mounting structure |
| CN110861111B (en) * | 2019-12-03 | 2021-02-26 | 哈尔滨工业大学 | Micro-nano robot control platform with magnetic field and electric field coupling effect |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009022280A2 (en) * | 2007-08-14 | 2009-02-19 | Koninklijke Philips Electronics N.V. | Transport module of a single-cartridge diagnostic device |
| CN103675303B (en) * | 2010-07-23 | 2016-02-03 | 贝克曼考尔特公司 | Sensing system |
| CN102703312B (en) * | 2012-05-24 | 2014-03-19 | 中国科学院北京基因组研究所 | DNA (Deoxyribose Nucleic Acid) sequencer |
| CN104266885B (en) * | 2014-07-25 | 2016-12-07 | 安徽省一一通信息科技有限公司 | A kind of automaied sample processing system |
-
2015
- 2015-10-27 CN CN201510706066.7A patent/CN105259165B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN105259165A (en) | 2016-01-20 |
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