CN105254662A - 水溶性对乙酰氨基酚类似物 - Google Patents
水溶性对乙酰氨基酚类似物 Download PDFInfo
- Publication number
- CN105254662A CN105254662A CN201510381430.7A CN201510381430A CN105254662A CN 105254662 A CN105254662 A CN 105254662A CN 201510381430 A CN201510381430 A CN 201510381430A CN 105254662 A CN105254662 A CN 105254662A
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- Prior art keywords
- paracetamol
- prodrug
- compound
- preparation
- illness
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
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- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
Landscapes
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- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
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| AU2009249071A1 (en) | 2008-05-20 | 2009-11-26 | Neurogesx, Inc. | Hepatoprotectant acetaminophen mutual prodrugs |
| JP5519645B2 (ja) | 2008-05-20 | 2014-06-11 | ニューロジェシックス， インコーポレイテッド | カーボネートプロドラッグおよびそれを使用する方法 |
| BRPI0912326A2 (pt) | 2008-05-20 | 2015-10-06 | Neurogesx Inc | análogos de acetaminofeno hidrossolúveis |
| EP2177215A1 (en) | 2008-10-17 | 2010-04-21 | Laboratorios Del. Dr. Esteve, S.A. | Co-crystals of tramadol and NSAIDs |
| ES2779225T3 (es) * | 2011-04-08 | 2020-08-14 | Sphaera Pharma Pte Ltd | Reactivos de merilformilo sustituido y procedimiento de uso de los mismos para modificar propiedades fisicoquímicas y/o farmacocinéticas de compuestos |
| JP6029670B2 (ja) | 2011-09-22 | 2016-11-24 | アコーダ セラピューティクス、インク． | アセトアミノフェンコンジュゲートおよびその組成物ならびにその使用方法 |
| AU2014306759B2 (en) | 2013-08-12 | 2018-04-26 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
| WO2015095391A1 (en) | 2013-12-17 | 2015-06-25 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| WO2016010771A1 (en) | 2014-07-17 | 2016-01-21 | Pharmaceutical Manufacturing Research Services, Inc. | Immediate release abuse deterrent liquid fill dosage form |
| CN117164657A (zh) | 2014-08-12 | 2023-12-05 | 莫纳什大学 | 定向淋巴的前药 |
| CA2964628A1 (en) | 2014-10-20 | 2016-04-28 | Pharmaceutical Manufacturing Research Services, Inc. | Extended release abuse deterrent liquid fill dosage form |
| CA2965379A1 (en) | 2014-10-21 | 2016-04-28 | Abbvie Inc. | Carbidopa and l-dopa prodrugs and methods of use |
| EP3265097A4 (en) | 2015-03-03 | 2018-11-07 | Kindred Biosciences Inc. | Compositions and methods for treatment and prevention of pyrexia in horses |
| JP7118888B2 (ja) | 2015-09-08 | 2022-08-16 | モナッシュ ユニバーシティ | リンパ指向性プロドラッグ |
| JP2019515908A (ja) * | 2016-04-20 | 2019-06-13 | アッヴィ・インコーポレイテッド | カルビドパ及びｌ−ドパプロドラッグ並びに使用方法 |
| US11883497B2 (en) | 2017-08-29 | 2024-01-30 | Puretech Lyt, Inc. | Lymphatic system-directing lipid prodrugs |
| EP3675838A4 (en) | 2017-08-29 | 2021-04-21 | PureTech LYT, Inc. | LIPID PRODRUGS DIRECTED TO THE LYMPHATIC SYSTEM |
| US11608345B1 (en) | 2017-12-19 | 2023-03-21 | Puretech Lyt, Inc. | Lipid prodrugs of rapamycin and its analogs and uses thereof |
| US11304954B2 (en) | 2017-12-19 | 2022-04-19 | Puretech Lyt, Inc. | Lipid prodrugs of mycophenolic acid and uses thereof |
| EP3727362A4 (en) | 2017-12-19 | 2021-10-06 | PureTech LYT, Inc. | MYCOPHENOLIC ACID LIPID PRODRUGS AND THEIR USES |
| AU2019379806B2 (en) | 2018-11-15 | 2025-08-14 | Abbvie Inc. | Pharmaceutical formulations for subcutaneous administration |
| WO2021041800A1 (en) | 2019-08-30 | 2021-03-04 | Remedy Diagnostics LLC | Transdermal device comprising pain molecules |
| CN115348864A (zh) | 2020-02-05 | 2022-11-15 | 纯技术Lyt股份有限公司 | 神经甾体的脂质前药 |
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| US5985856A (en) * | 1997-12-31 | 1999-11-16 | University Of Kansas | Water soluble prodrugs of secondary and tertiary amine containing drugs and methods of making thereof |
| CN1357000A (zh) * | 1998-08-07 | 2002-07-03 | 堪萨斯州立大学 | 位阻醇或酚的水溶性前药 |
| WO2005077394A1 (en) * | 2004-02-11 | 2005-08-25 | Ramot At Tel-Aviv University Ltd | Compositions for treatment of cancer and inflammation with curcumin and at least one nsaid |
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| US5272171A (en) * | 1992-02-13 | 1993-12-21 | Bristol-Myers Squibb Company | Phosphonooxy and carbonate derivatives of taxol |
| US6750216B2 (en) * | 1996-03-08 | 2004-06-15 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| IT1282736B1 (it) * | 1996-05-21 | 1998-03-31 | Angelini Ricerche Spa | Uso di derivati del p-amminofenolo per preparare composizioni farmaceutiche utili nel trattamento di malattie neurodegenerative |
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| WO1999038873A1 (en) * | 1998-01-29 | 1999-08-05 | Bristol-Myers Squibb Company | Phosphate derivatives of diaryl 1,3,4-oxadiazolone |
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| AU2003210850A1 (en) * | 2002-02-05 | 2003-09-02 | Bristol-Myers Squibb Company | N-substituted3-hydroxy-4-pyridinones and pharmaceuticals containing thereof |
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| AU2003282624A1 (en) * | 2002-11-14 | 2004-06-03 | Syntarga B.V. | Prodrugs built as multiple self-elimination-release spacers |
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2009
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- 2009-05-20 CA CA2724877A patent/CA2724877C/en not_active Expired - Fee Related
- 2009-05-20 EP EP09751523.3A patent/EP2291348A4/en not_active Withdrawn
- 2009-05-20 AU AU2009249067A patent/AU2009249067A1/en not_active Abandoned
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- 2009-05-20 RU RU2010151952/04A patent/RU2010151952A/ru not_active Application Discontinuation
- 2009-05-20 WO PCT/US2009/044743 patent/WO2009143295A1/en not_active Ceased
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- 2009-05-20 US US12/993,088 patent/US20110212926A1/en not_active Abandoned
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2010
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2014
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2016
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2018
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2020
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Patent Citations (4)
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| US4322410A (en) * | 1978-12-15 | 1982-03-30 | Jacques Dugniolle | P-Acetaminophenyl phosphate salts as analgesics and antipyretics |
| US5985856A (en) * | 1997-12-31 | 1999-11-16 | University Of Kansas | Water soluble prodrugs of secondary and tertiary amine containing drugs and methods of making thereof |
| CN1357000A (zh) * | 1998-08-07 | 2002-07-03 | 堪萨斯州立大学 | 位阻醇或酚的水溶性前药 |
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| BRPI0912326A2 (pt) | 2015-10-06 |
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| KR20110018897A (ko) | 2011-02-24 |
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| IL209382A0 (en) | 2011-01-31 |
| KR101698028B1 (ko) | 2017-01-26 |
| EP2291348A4 (en) | 2013-05-15 |
| JP2016084359A (ja) | 2016-05-19 |
| US20110212926A1 (en) | 2011-09-01 |
| US20200002364A1 (en) | 2020-01-02 |
| WO2009143295A1 (en) | 2009-11-26 |
| JP5757864B2 (ja) | 2015-08-05 |
| US10442826B2 (en) | 2019-10-15 |
| CA2724877C (en) | 2016-09-13 |
| US9981998B2 (en) | 2018-05-29 |
| RU2010151952A (ru) | 2012-06-27 |
| EP2291348A1 (en) | 2011-03-09 |
| CN102149672A (zh) | 2011-08-10 |
| US20190092795A1 (en) | 2019-03-28 |
| MX2010012648A (es) | 2010-12-14 |
| JP2014111658A (ja) | 2014-06-19 |
| JP2020114876A (ja) | 2020-07-30 |
| JP2011520977A (ja) | 2011-07-21 |
| US20160264605A1 (en) | 2016-09-15 |
| JP6063072B2 (ja) | 2017-01-18 |
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