CN105249929A - Breast tumor blood oxygen nano enhancing functional imaging and examination system - Google Patents
Breast tumor blood oxygen nano enhancing functional imaging and examination system Download PDFInfo
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- CN105249929A CN105249929A CN201510749800.8A CN201510749800A CN105249929A CN 105249929 A CN105249929 A CN 105249929A CN 201510749800 A CN201510749800 A CN 201510749800A CN 105249929 A CN105249929 A CN 105249929A
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Abstract
A breast tumor blood oxygen nano enhancing functional imaging system comprises two parts, and the first part is measurement and imaging of the partial blood oxygen content of a breast lesion region; the second part is three operator processing of infrared images, and three images are formed: (1) the change and the number of blood vessels of the lesion region are shown; (2) the structural change of the lesion region is shown; (3) the edge of the lesion region is shown. By adopting a visual nano targeting technology, the nanoparticles are utilized to automatically target tumor tissues, the blood oxygen enhancing functional imaging is realized, the omission probability is reduced under the action of infrared, and the diagnosis and treatment effects are improved. Tumor images of tracer angiography are subjected to acquisition and processing, the outline, the region and the boundary of the tumor are clearly shown, and the effective guidance is provided for the operation treatment of medical personnel.
Description
Technical field
The invention belongs to technical field of medical instruments, particularly related to a kind of breast tumor blood oxygen nanometer and strengthened functional imaging and check system.
Background technology
Breast carcinoma is the modal malignant tumor of women worldwide, and its global incidence is in rising trend.China's breast carcinoma has occupied first of female malignant, and sickness rate increases very fast and is tending towards rejuvenation, and mortality rate constantly rises.At present, the auxiliary examination methods of diagnosis of breast disease is more, and mainly contain the morphological examination of near-infrared, ultrasonic, molybdenum target, cytology etc., the defect of these modes can not obtain organ dysfunction metabolic condition from organizational structure.The mammary gland blood-oxygen functional imaging system that morphology and function assessment combine, as a kind of new inspection method, has good accuracy to breast carcinoma and carcinoid diagnosis.
In recent years, domestic patent database discloses some relevant patented technologies, " mammary tissue blood oxygen function imaging system " as patent No. CN200810213258.4 utilizes the Visible-to-Near InfaRed light source of the continuous spectrum of 500nm-1500nm, image pick-up card has two video input ports, the signal of telecommunication that the photographic head of two in detector exports is converted to digital quantity respectively from analog quantity, digital quantity is input to processing system again, and digital quantity is carried out process and obtains mammary tissue blood oxygen function data by processing system application mammary gland tissue cubage formula.The usefulness of this invention is the distribution that can obtain mammary tissue blood oxygen, so by the distribution situation of mammary tissue blood oxygen be Diagnosis of Breast pathological changes, pathological changes location and treatment effective foundation is provided.And for example " a kind of mammary blood oxygen function image examination system " of patent No. CN201110247414.0 provides a kind of noinvasive, without latent lesion, the mammary blood oxygen function image examination system showing the functional diagram picture of cell or tissue.This system comprises the PC that is connected to contact unit and acceptor unit.The process software comprising mastery routine and four dynamic link libraries is installed in PC.Four dynamic link libraries are gather dynamic link libraries, blood oxygen analysis dynamic link libraries, picture enhancing dynamic link libraries, report generation storage dynamic link libraries respectively.The usefulness of this invention overcomes traditional X-ray light, B ultrasonic etc. to detect in mastopathy process and produce the shortcomings such as wound, pollution, recall rate are low.
Above system is all the new diagnostic equipment of rapid screening early-stage breast cancer and various mastopathy, but the accuracy rate of its work up still needs to be improved further.
The information being disclosed in this background technology part is only intended to increase the understanding to general background of the present invention, and should not be regarded as admitting or imply in any form that this information structure has been prior art that persons skilled in the art are known.
Summary of the invention
For overcoming the deficiencies in the prior art, a kind of breast tumor blood oxygen nanometer is the object of the present invention is to provide to strengthen functional imaging and check system.This system is better than existing for breast examination system comprehensively, effectively improves the early diagnosis accuracy rate of breast tumor.
To achieve these goals, present invention employs following technical scheme:
A kind of breast tumor blood oxygen nanometer strengthens function imaging system, comprises two parts, and Part I is mensuration and the imaging of local, breast lesion position oxygen content; Part II is the process of infrared image three operator, forms three sub-pictures: the change of (1) lesions showed position blood vessel and quantity; (2) lesions showed portion structure change); (3) diseased region edge display.
A kind of breast tumor blood oxygen nanometer strengthens functional imaging and check system, comprises main control computer, device controller, infrared imaging module, infrared ray generation module and red-emitting module; Described main control computer is connected by universal serial bus with device controller; Described device controller and infrared ray generation model calling; Described infrared imaging module is connected with main control computer.
As preferably, described main control computer provide the input of user interface, information, result output display and printing, galactophore image analysis and treament, with the communication of device controller and the data analysis of system and process.
As preferably, described device controller plays a kind of effect of gateway between main control computer and modules, equipment controls to be connected with computer by RS232 bus, be responsible for receiving the control command from computer and data, and according to received order, modules is controlled, reads state and the data of modules simultaneously, then send main control computer to.Avoid modules be directly directly connected with main control computer and cause the complicated burden with increasing main control computer of line.
As preferably, described infrared imaging module is provided with the image pick-up card, the infrared CCD photographic head that connect successively.The function of infrared imaging module is the blood flow blood oxygen of collection lesion and is colored tumor cell image, then gives main control computer and carries out treatment and analysis.
As preferably, described infrared CCD photographic head is provided with infrared fileter, makes gathered image by the interference of extraneous visible ray, reduces background noise.
As preferably, described infrared ray generation module is provided with the infrared ray drive circuit and infrared emitting probe that connect successively.The function of infrared ray drive circuit and infrared emitting probe is under the control of device controller, produce the infrared drive singal of characteristic frequency and pulsewidth, infrared emitting probe is driven to produce the infrared light of certain power and wavelength, and be irradiated to treatment target corresponding site, provide necessary light source for infrared CCD photographic head carries out infrared image acquisition.
As preferably, described targeted nano tumor staining agent is that synthesis is separated a kind of full stress-strain from the raw material of Chinese medicine such as Bombyx mori L., Yellow Fructus Gardeniae, Semen sojae atricolor that is produced from Guangxi, and glaucous targeted nano tumor staining agent, green photosensitizer, carry oxygenation agent simultaneously.Enter targeted nano granule in body by local injection or the approach such as oral to combine from motion tracking infected tumor cell surface receptor, tumor cell is coloured to the aeruginous tissue of Glassless.This targeted nano tumor staining agent, nontoxic, bio-compatibility good, full stress-strain, the feature such as biodegradable.
As preferably, described hydrophobic amine is putrescine, spermine or spermidine, or the amine of synthesis, and containing straight chain or unsaturated fatty acids base or aryl, wherein at least containing a primary amine groups, or multiple primary amine groups, preferably alkyl is wherein at least about the alkyl of C10 or more.
Breast tumor blood oxygen nanometer of the present invention strengthens the operation principle of functional imaging and check system:
The present invention adopts the Bombyx mori L. produced from Guangxi, Yellow Fructus Gardeniae, be separated in the raw material of Chinese medicine such as Semen sojae atricolor, extract, modified one-tenth one class has the micromolecule polypeptide of targeting to be the nanoparticle of targeting agent to breast carcinoma, carry oxygenation agent simultaneously, photosensitizer, targeting breast tissues in body is entered by local injection or the approach such as oral, targeted nano granule can excite infected tumor's cell surface receptor to combine from motion tracking, tumor cell is coloured to the aeruginous tissue of Glassless, increase the blood oxygen concentration of focus local simultaneously, at lesion region enrichment photosensitizer, obtain the high-resolution imaging of lesion.
Infrared ray generation module, under the control of device controller, produces the infrared drive singal of characteristic frequency and pulsewidth, drives infrared emitting probe to produce the infrared light of certain power and specific wavelength, and is irradiated to inspected object corresponding site; Then, the blood flow of infrared imaging module acquires treatment target specific region, blood oxygen and the tumor cell image be colored, then feed back to main control computer and carry out treatment and analysis; Main control computer, by collected data analysis process, draws check result.
Compared with prior art, the present invention has following beneficial effect:
The present invention adopts visual nano target technology, utilizes nanoparticle automatic target to tumor tissues, can realize blood-oxygen functional Enhanced Imaging, under infrared ray action, can reduce and omits probability, improve Clinics and Practices effect.The present invention carries out acquisition process to the tumor image of tracer radiography, clearly shows the wheel hub of tumor and region and border, for the operation treatment of healthcare givers provides effective guiding.
Accompanying drawing explanation
Fig. 1 is the structural representation that breast tumor blood oxygen nanometer of the present invention strengthens functional imaging and check system.
Detailed description of the invention
Below in conjunction with specific embodiment, elaboration detailed is further done to the present invention, but embodiments of the present invention are not limited to the scope that embodiment represents.These embodiments only for illustration of the present invention, but not for limiting the scope of the invention.In addition, after reading content of the present invention, those skilled in the art can do various amendment to the present invention, and these equivalent variations fall within appended claims limited range of the present invention equally.
embodiment 1:
As shown in Figure 1, a kind of breast tumor blood oxygen nanometer strengthens functional imaging and check system, comprises targeted nano tumor staining agent main control computer, device controller, infrared imaging module and infrared ray generation module; Described main control computer is connected by universal serial bus with device controller; Described device controller and infrared ray generation model calling; Described infrared imaging module is connected with main control computer by bus.
Described targeted nano stain is the targeted nano granule entered by local injection or the approach such as oral in body, can from motion tracking infected tumor cell, combine with surface receptor, tumor tissues or cell dyeing are become the aeruginous tissue of Glassless, the side effect of normal tissue cytotoxic and damage.
Described infrared imaging module is provided with the image pick-up card, the infrared CCD photographic head that connect successively.Described infrared CCD photographic head is provided with infrared fileter.Described infrared ray generation module is provided with the infrared ray drive circuit and infrared emitting probe that connect successively.
embodiment 2:
The preparation of nano target photosensitive liposomes (targeted nano tumor staining agent).To in the Polyethylene Glycol photosensitive liposomes organic solution in embodiment 1, add Polyethylene Glycol-maleimide (PEG-mal), after stirring, add the target polypeptide (5-50 amino acid residue peptide peptide, as HS-CRGDK, PEG-mal:peptide=1:1.2) containing sulfydryl, room temperature continues stirring and spends the night, evaporation removes out organic solvent, and add water ultrasonic dissolution, obtains navy blue photosensitive liposomes aqueous solution.Through dialysis, or ultrafiltration, or after crossing desalting column, be lyophilized into powdery, obtain blue nano target photosensitive liposomes, lucifuge under low temperature, can preserve for a long time.
embodiment 3: breast tumor blood oxygen nanometer strengthens the clinical use surveyllance of functional imaging and check system
3.1 physical data
In October ,-2015 in October, 2013, altogether check patient 4650 example, age 12-78 year, examinee without puncture and treatment history.Confirm through pathological examination, in 4650 routine patients, 3524 examples are diagnosed as cyclomastopathy, and 153 examples are malignant tumor, and 873 examples are benign lesion.
3.2 inspection method
Apply breast tumor blood oxygen nanometer of the present invention to strengthen functional imaging and check system and carry out imaging.During inspection, patient gets seat, and upper body is exposed, position of leaning forward, and is placed in rear under the mammary gland of suspicious side, each quadrant of searchlighting mammary gland and mammary areola district to pop one's head in, and gathers mammary gland respective image and in systems in which image is carried out adjustment to proofread, and marks in suspicious lesions region.First adopt three operator processing systems to image carry out the display of blood vessel inside and outside diseased region, etc. grey scale curve display, the display of ghost edge three kinds of unique image processing modes.Then system is formed with color change is that the function imaging system represented provides the report of real number numeral blood, oxygen content relative value, draw the results such as high blood hypoxia, high blood hyperoxia, low blood hypoxia, low blood hyperoxia, the flat oxygen of blood are flat, the flat hyperoxia of blood, high blood hypoxia is the evaluation criterion of malignant breast tumor; High blood hyperoxia and the flat hypoxia of blood are the evaluation criterion of doubtful malignant breast tumor; Other are the evaluation criterion of benign breast disease.Record patient examining report take pathological replacement as contrast foundation.
3.3 diagnostic criteria
In system to three operator diagnostic criterias of focal area be: three ways of calculating subimage refers to disorderly abnormal, the focal exception of focal area striograph display equi intensity curve extremely, blood vessel is clear has (numerous) blood vessel to occur, and traveling is disorderly, rim detection burr shape etc.System to focal area blood and oxygen content diagnostic criteria be high blood hypoxia, high blood hyperoxia, the feature such as high oxygen pressure is flat, the flat hypoxia of blood, the flat oxygen of blood flat, the flat hyperoxia of blood, low blood hypoxia, low blood oxygen are flat, low blood hyperoxia, report hemorrhage content and oxygen content relative value with real figure.Different due to blood in organizational information and focal area tissue metabolism and oxygen content, high blood hypoxia is malignant breast tumor diagnostic criteria; High blood hyperoxia and the flat hypoxia of blood are doubtful malignant breast tumor diagnostic criteria; Low blood hyperoxia or other features are benign breast disease diagnostic criteria.Record examining report take pathological replacement as contrast foundation.
3.4 examining report
This group case blood-oxygen functional systems axiol-ogy is reported as high blood hypoxia 127 example, low blood hyperoxia 899 example, according to the evaluation criterion of system data, evaluates malignant breast tumor 127 example, benign breast lesions 899 example.
3.5 with Pathological correlation and conclusion
Result shows: 127 examples are reported as high blood hypoxia person, and underwent operative proved by pathology 122 example is breast carcinoma, and 3 examples are intraductal papilloma, and 2 examples are cyclomastopathy companion chronic inflammatory disease, and its diagnostic accordance rate is 96.1%.899 examples are reported as low blood hyperoxia person, underwent operative proved by pathology, and 19 examples are breast carcinoma, and 407 examples are fibroma, and 289 examples are fibroadenosis of breast, and 65 examples are intraductal papilloma, and 119 examples are mammary gland cystic fibroadenosis and cyst, and its diagnostic accordance rate is 97.9%.This group case application breast tumor blood oxygen nanometer strengthens functional imaging and check system, and diagnosis of malignant tumor rate is 96.1%, and benign lesion diagnosis is 97.9%.
The aforementioned description to concrete exemplary of the present invention is to illustrate and the object of illustration.These descriptions not want the present invention to be defined as disclosed precise forms, and obviously, according to above-mentioned instruction, can much change and change.The object selected exemplary embodiment and describe is to explain certain principles of the present invention and practical application thereof, thus those skilled in the art can be realized and utilize various different exemplary of the present invention and various different selection and change.Scope of the present invention is intended to limited by claims and equivalents thereof.
Claims (9)
1. breast tumor blood oxygen nanometer strengthens a function imaging system, it is characterized in that: comprise two parts, and Part I is mensuration and the imaging of local, breast lesion position oxygen content; Part II is the process of infrared image three operator, forms three sub-pictures: the change of (1) lesions showed position blood vessel and quantity; (2) lesions showed portion structure change); (3) diseased region edge display.
2. breast tumor blood oxygen nanometer strengthens functional imaging and a check system, it is characterized in that: comprise main control computer, device controller, infrared imaging module, infrared ray generation module and red-emitting module; Described main control computer is connected by universal serial bus with device controller; Described device controller and infrared ray generation model calling; Described infrared imaging module is connected with main control computer.
3. breast tumor blood oxygen nanometer according to claim 2 strengthens functional imaging and check system, it is characterized in that: described main control computer provide the input of user interface, information, result output display and printing, galactophore image analysis and treament, with the communication of device controller and the data analysis of system and process.
4. breast tumor blood oxygen nanometer according to claim 2 strengthens functional imaging and check system, it is characterized in that: described device controller plays a kind of effect of gateway between main control computer and modules, equipment controls to be connected with computer by RS232 bus, be responsible for receiving the control command from computer and data, and according to received order, modules is controlled, reads state and the data of modules simultaneously, then send main control computer to.Avoid modules be directly directly connected with main control computer and cause the complicated burden with increasing main control computer of line.
5. breast tumor blood oxygen nanometer according to claim 2 strengthens functional imaging and check system, it is characterized in that: described infrared imaging module is provided with the image pick-up card, the infrared CCD photographic head that connect successively; The function of infrared imaging module is the blood flow blood oxygen of collection lesion and is colored tumor cell image, then gives main control computer and carries out treatment and analysis.
6. breast tumor blood oxygen nanometer according to claim 2 strengthens functional imaging and check system, it is characterized in that: described infrared CCD photographic head is provided with infrared fileter, makes gathered image not by the interference of extraneous visible ray, reduces background noise.
7. breast tumor blood oxygen nanometer according to claim 2 strengthens functional imaging and check system, it is characterized in that: described infrared ray generation module is provided with the infrared ray drive circuit and infrared emitting probe that connect successively; The function of infrared ray drive circuit and infrared emitting probe is under the control of device controller, produce the infrared drive singal of characteristic frequency and pulsewidth, infrared emitting probe is driven to produce the infrared light of certain power and wavelength, and be irradiated to treatment target corresponding site, provide necessary light source for infrared CCD photographic head carries out infrared image acquisition.
8. breast tumor blood oxygen nanometer according to claim 2 strengthens functional imaging and check system, it is characterized in that: described targeted nano tumor staining agent is that synthesis is separated a kind of full stress-strain from the raw material of Chinese medicine such as Bombyx mori L., Yellow Fructus Gardeniae, Semen sojae atricolor that is produced from Guangxi, glaucous targeted nano tumor staining agent, green photosensitizer, carry oxygenation agent simultaneously.Enter targeted nano granule in body by local injection or the approach such as oral to combine from motion tracking infected tumor cell surface receptor, tumor cell is coloured to the aeruginous tissue of Glassless.This targeted nano tumor staining agent, nontoxic, bio-compatibility good, full stress-strain, the feature such as biodegradable.
9. breast tumor blood oxygen nanometer according to claim 2 strengthens functional imaging and check system, it is characterized in that: described hydrophobic amine is putrescine, spermine or spermidine, or the amine of synthesis, containing straight chain or unsaturated fatty acids base or aryl, wherein at least containing a primary amine groups, or multiple primary amine groups, the alkyl be preferably wherein is C10 or more.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1810210A (en) * | 2005-09-02 | 2006-08-02 | 深圳市国基科技有限公司 | Mammary gland blood oxygen function imaging method and system |
| CN101366632A (en) * | 2004-08-03 | 2009-02-18 | 武汉一海数字工程有限公司 | Mammary tissue blood oxygen function imaging system |
| CN102579012A (en) * | 2012-03-15 | 2012-07-18 | 天津大学 | Dynamic fluorescence-optical breast tomography device on basis of phase locking photon counting measurement |
| CN103267850A (en) * | 2013-04-27 | 2013-08-28 | 深圳先进技术研究院 | Probe for pathological diagnosis of tumor, and preparation method and application thereof |
| CN103480009A (en) * | 2013-09-17 | 2014-01-01 | 北京肿瘤医院 | Bi-modal tumor targeted nano particle photographic developer and method for preparing same |
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- 2015-11-06 CN CN201510749800.8A patent/CN105249929A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101366632A (en) * | 2004-08-03 | 2009-02-18 | 武汉一海数字工程有限公司 | Mammary tissue blood oxygen function imaging system |
| CN1810210A (en) * | 2005-09-02 | 2006-08-02 | 深圳市国基科技有限公司 | Mammary gland blood oxygen function imaging method and system |
| CN102579012A (en) * | 2012-03-15 | 2012-07-18 | 天津大学 | Dynamic fluorescence-optical breast tomography device on basis of phase locking photon counting measurement |
| CN103267850A (en) * | 2013-04-27 | 2013-08-28 | 深圳先进技术研究院 | Probe for pathological diagnosis of tumor, and preparation method and application thereof |
| CN103480009A (en) * | 2013-09-17 | 2014-01-01 | 北京肿瘤医院 | Bi-modal tumor targeted nano particle photographic developer and method for preparing same |
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