CN105233235A - Traditional Chinese medicine compound treating yang deficiency and wet cold type dysmenorrheal and preparation method thereof - Google Patents
Traditional Chinese medicine compound treating yang deficiency and wet cold type dysmenorrheal and preparation method thereof Download PDFInfo
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- CN105233235A CN105233235A CN201510798491.3A CN201510798491A CN105233235A CN 105233235 A CN105233235 A CN 105233235A CN 201510798491 A CN201510798491 A CN 201510798491A CN 105233235 A CN105233235 A CN 105233235A
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Abstract
The invention discloses a traditional Chinese medicine compound treating yang deficiency and wet cold type dysmenorrheal and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine processing. The traditional Chinese medicine compound treating yang deficiency and wet cold type dysmenorrheal is prepared from, by weight, 15-25 parts of rhizoma corydalis, 15-25 parts of angelica sinensis, 10-20 parts of cassia twigs, 10-15 parts of sichuan lovage rhizome, 10-15 parts of motherwort, 5-15 parts of lindera aggregate, 5-15 parts of dried ginger, 6-12 parts of donkey-hide glue, 5-10 parts of peony tree root bark, 5-15 parts of radix bupleuri, 5-15 parts of fructus aurantii, 5-15 parts of peach kernels, 5-10 parts of flos carthami, 10-15 parts of white peony roots and 5-10 parts of myrrh. The invention further discloses the preparation method of the traditional Chinese medicine compound. According to the pattern of traditional Chinese medicine diagnosis and treatment based on overall analysis and assistant and guide, the traditional Chinese medicines are subjected to scientific compatibility, and the effective medicine combination is provided, which is a key point of the compound. The compound can smoothen the liver and relieve depression, dredge collaterals, promote blood circulation to remove blood stasis and regulate qi to alleviate pain, is quick in healing, has no obvious side effect, and is good in treatment effect.
Description
Technical field
The present invention relates to processing technique of Chinese herbs field, is a kind ofly treat Chinese medicine composition of the raw type dysmenorrhea of yang deficiency and preparation method thereof specifically.
Background technology
Dysmenorrhea refers between moon paramenstrum, lower abdomen and waist spasmic pain, with symptoms such as Nausea and vomiting, limbs colds time serious, is especially more common in Unmarried women.Dysmenorrhea can be divided into primary dysmenorrhea and secondary dysmenorrhea, and primary dysmenorrhea generally starts just to occur in menophania, and secondary dysmenorrhea can be caused by genital organ diseases such as edeitis, hysteromyoma, endometriosis.Along with the raising of people's living standard, sickness rate is but in the trend increased year by year.
But, modern medicine is not yet completely clear and definite to the cause of disease of primary dysmenorrhea, think relevant with many factors, comprise Nervous and Mental Factors, prostaglandin, leukotriene, vasopressin, oxytocin increase relevant, make the erratic spasm in uterus, intrauterine pressure increases, uterine blood flow reduces, cause dysmenorrhea to occur, there is no specific short so far, generally all adopt symptomatic treatment.Therefore, market is badly in need of one and treats definitely, the medicine of the treatment primary dysmenorrhea that toxic and side effects is little.
In the prior art, be in the Chinese invention patent of 93118727.3 at application number, disclose a kind of medicated bag for curing menalgia for the treatment of woman month dysmenorrhoea, paper " from intending Pericarpium Citri Reticulatae Viride Rhizoma Cyperi Rhizoma Corydalis loose treatment dysmenorrhea 47 example " also discloses a kind of Chinese medicine compound for the treatment of dysmenorrhea, but be through clinical discovery, although both all have good curative effect, the cycle is long, easily repeatedly.The pain relieving of suiting the medicine to the illness of current doctor trained in Western medicine easily produces drug resistance, and adopt hormone therapy side effect large, tablet for alleviating pain stops only or alleviates dysmenorrhea, and long-term taking is harmful to women's health.
Chinese medicine is classified as cold, hot, empty, real four ends the cause of disease of primary dysmenorrhea, and four or the origin cause of formation or synthetic origin separately, or reciprocal causation, finally cause Chong and Ren channel disorder, stagnation of QI and blood may bring about pain or not Rong Ze pain, cause the generation of dysmenorrhea, wherein stagnation of QI and blood may bring about pain is clinical common.Because the primary disease course of disease is longer, easily repeatedly, clinical syndrome differentiation typing is varied, and Chinese medicine decoction brings inconvenience to patient in addition.Existing Chinese patent medicine has TIANQI TONGJING JIAONANG, GUIZHI FULING JIAONANG etc., has good curative effect, also has most women to use WUJI BAIFENG pill for curing, but this medicine price is high, complicated process of preparation.For this reason, explore clinical efficacy good, short treating period, is easily had important clinical value by the Chinese patent medicine that extensive patients accepts.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind ofly treats Chinese medicine composition of the raw type dysmenorrhea of yang deficiency and preparation method thereof.
For solving the problems of the technologies described above, technical scheme of the present invention is: a kind of Chinese medicine composition for the treatment of the raw type dysmenorrhea of yang deficiency, is prepared from: corydalis tuber 15-25 part, Radix Angelicae Sinensis 15-25 part, Ramulus Cinnamomi 10-20 part, Rhizoma Chuanxiong 10-15 part, Herba Leonuri 10-15 part, Radix Linderae 5-15 part, Rhizoma Zingiberis 5-15 part, Colla Corii Asini 6-12 part, Cortex Moutan 5-10 part, Radix Bupleuri 5-15 part, Fructus Aurantii 5-15 part, Semen Persicae 5-15 part, Flos Carthami 5-10 part, Radix Paeoniae Alba 10-15 part, Myrrha 5-10 part by the raw material of following weight portion and pharmaceutically acceptable carrier.
As preferred technical scheme, described a kind of Chinese medicine composition for the treatment of the raw type dysmenorrhea of yang deficiency, is prepared from by the raw material of following weight portion and pharmaceutically acceptable carrier: corydalis tuber 20 parts, Radix Angelicae Sinensis 20 parts, Ramulus Cinnamomi 15 parts, Rhizoma Chuanxiong 12.5 parts, Herba Leonuri 12.5 parts, the Radix Linderae 10 parts, Rhizoma Zingiberis 10 parts, 9 parts, Colla Corii Asini, Cortex Moutan 7.5 parts, Radix Bupleuri 10 parts, Fructus Aurantii 10 parts, 10 parts, Semen Persicae, 7.5 parts, Flos Carthami, the Radix Paeoniae Alba 12.5 parts, Myrrha 7.5 parts.
As preferred technical scheme, described a kind of Chinese medicine composition for the treatment of the raw type dysmenorrhea of yang deficiency is tablet, capsule, granule, oral liquid, pill.
Present invention also offers the preparation method of this Chinese medicine composition, comprise the following steps:
(1) corydalis tuber, Radix Angelicae Sinensis, Ramulus Cinnamomi, Rhizoma Chuanxiong, Herba Leonuri, the Radix Linderae, Rhizoma Zingiberis, Colla Corii Asini, Cortex Moutan, Radix Bupleuri, Fructus Aurantii, Semen Persicae, Flos Carthami, the Radix Paeoniae Alba, Myrrha is taken respectively by weight, for subsequent use;
(2) medical material in step (1) is decocted with water 2-4 time, each 2-3 hour, collecting decoction;
(3) filter above-mentioned decocting liquid, clear paste filtrate being concentrated into relative density 1.32-1.35 at 24-40 DEG C is cooled to room temperature;
(4) add alcohol reflux 2-6 time of the 70-80% of 4-7 times amount, filter, from filtrate, reclaim ethanol;
(5) the mixed filtrate cold drying of ethanol of will reclaim, pulverizes, adds pharmaceutically acceptable carrier, and mixing, makes medicament.
Treat in the Chinese medicine composition of the raw type dysmenorrhea of yang deficiency the present invention is a kind of, pharmaceutically acceptable carrier is selected from one or more in filler, binding agent, disintegrating agent, lubricant, surfactant or correctives.
A kind of application of Chinese medicine composition in the medicine of preparation treatment dysmenorrhea for the treatment of the raw type dysmenorrhea of yang deficiency that the invention still further relates to.
The property of medicine of crude drug that the present invention adopts, pharmacology and effect are as follows:
Corydalis tuber: invigorate blood circulation, dissipating blood stasis, regulates the flow of vital energy, pain relieving.Control all pains of trusted subordinate's waist knee joint, menoxenia.
Radix Angelicae Sinensis: tonifying blood and regulating menstruation, promoting blood circulation and stopping pain; Anti-anemia action, anticoagulation, improve immunity.
Ramulus Cinnamomi: acrid in the mouth, sweet, warm in nature, GUIXIN, lung, urinary bladder channel, diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, controls exterior syndrome due to wind-cold, shoulder back of the body podomere ache, thoracic obstruction phlegm retention, amenorrhea lump in the abdomen.
Semen Persicae: blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.
Rhizoma Chuanxiong: supplementing QI and nourishing YIN, rises loose dispeling the wind, reducing swelling and alleviating pain, blood-activating and qi-promoting.
Herba Leonuri: bitter, pungent, is slightly cold, and returns liver, pericardium channel, promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria.
Colla Corii Asini: nourish heart and enrich blood, promotes the production of body fluid and enriches blood.
Flos Carthami: promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing; Anticoagulant.
The Radix Paeoniae Alba: regulating the liver and spleen, relieving spasm to stop pain, tonifying YIN holds back battalion.
The Radix Linderae: acrid in the mouth, warm in nature, return spleen, stomach, liver, kidney, urinary bladder channel, have promoting the circulation of QI to relieve pain, the effect of warming kidney for dispelling cold, main fullness in the chest and hypochondrium is vexed, abdominal distention, headache, colic of cold type pain, dysmenorrhea and puerperal abdonimal pain, frequent micturition, the enuresis.
Rhizoma Zingiberis: have another name called old ginger sheet etc., is that the perennial root of Rhizoma Zingiberis Recens digs out the section of afterwash impurity and to dry or low baking temperature is dried and formed, is called " warming middle-JIAO recuperating depleted YANG first key medicine ", has warming spleen and stomach for dispelling cold, the effect that recuperating depleted YANG is promoted blood circulation by the traditional Chinese medical science.
Radix Bupleuri: induce sweat and bring down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy, main fever caused by exogenous pathogens, alternate attack of chill and fever, malaria, hypochondriac pain due to stagnation of liverQI mammary swelling, headache dizziness, menoxenia, the proctoptosis of collapse of QI, uterine prolapse.
Fructus Aurantii: all have obvious excitation to the uterus flaccidity of unpregnancy and pregnant rabbit isolated uterine, uterus in place and unpregnancy rabbit, the uterine contraction rhythm and pace of moving things can be made to increase.
Myrrha: bitter, pungent, enter Liver Channel, has loose blood and relieving pain, detumescence and promoting granulation.
According to the general layout of the traditional Chinese medical science, Chinese medicine determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, monarch, carrying out scientific compatibility propose effective drug regimen to above-mentioned Chinese medicine, is a key point of the present invention.Have as the corydalis tuber of monarch drug of the present invention and Radix Angelicae Sinensis and invigorate blood circulation, enrich blood and the effect of regulating menstruation, but have certain injury for healthy cell, as adjuvant drug of the present invention, make the Fructus Aurantii of medicine and Colla Corii Asini etc. can balance the toxic and side effects of monarch drug, ministerial drug.By experiment, to the Be very effective for the treatment of primary dysmenorrhea, to human body almost without any toxic and side effects, by clinical experiment, what the present invention improved Chinese medicine decoction greatly puies forward effect, and shorten treatment cycle, relapse rate significantly reduces.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described further.
embodiment 1
Take corydalis tuber 150g respectively, Radix Angelicae Sinensis 150g, Ramulus Cinnamomi 100g, Rhizoma Chuanxiong 100g, Herba Leonuri 100g, Radix Linderae 50g, Rhizoma Zingiberis 50g, Colla Corii Asini 60g, Cortex Moutan 50g, Radix Bupleuri 50g, Fructus Aurantii 50g, Semen Persicae 50g, Flos Carthami 50g, Radix Paeoniae Alba 100g, Myrrha 50g, decoct with water 2 times, each 2 hours, collecting decoction, filter decocting liquid, clear paste filtrate being concentrated into relative density 1.32-1.35 at 40 DEG C is cooled to room temperature, add the alcohol reflux 2 times of 70% of 4 times amount, filter, ethanol is reclaimed from filtrate, filtrate cold drying after ethanol will be reclaimed, pulverize, add appropriate pharmaceutically acceptable carrier, this pharmaceutically acceptable carrier is dextrin and protein sugar, ratio is: 1.2:0.3, granulate after mix homogeneously, cold drying, granulate, packaging, obtain compositions of the present invention, it is granular form.The granule good drug efficacy prepared by this technique, and features good taste.
The dose of this granule can be decided according to the state of an illness of patient by doctor.Usual adult takes this granule 6g/ time, 3 times/day.
embodiment 2
Take corydalis tuber 200g respectively, Radix Angelicae Sinensis 200g, Ramulus Cinnamomi 150g, Rhizoma Chuanxiong 125g, Herba Leonuri 125g, Radix Linderae 100g, Rhizoma Zingiberis 100g, Colla Corii Asini 90g, Cortex Moutan 75g, Radix Bupleuri 100g, Fructus Aurantii 100g, Semen Persicae 100g, Flos Carthami 75g, Radix Paeoniae Alba 125g, Myrrha 75g, decoct with water 3 times, each 2.5 hours, collecting decoction, filter decocting liquid, clear paste filtrate being concentrated into relative density 1.32-1.35 at 30 DEG C is cooled to room temperature, add the alcohol reflux 3 times of 75% of 5 times amount, filter, ethanol is reclaimed from filtrate, filtrate cold drying after ethanol will be reclaimed, pulverize, add appropriate pharmaceutically acceptable carrier, this pharmaceutically acceptable carrier is dextrin and protein sugar, ratio is: 1.2:0.3, granulate after mix homogeneously, cold drying, granulate, packaging, obtain compositions of the present invention, it is tablet form.The tablet good drug efficacy prepared by this technique, and features good taste.
The dose of this tablet can be decided according to the state of an illness of patient by doctor.Usual adult takes this tablet 6g/ time, 3 times/day.
embodiment 3
Take corydalis tuber 250g, Radix Angelicae Sinensis 250g, Ramulus Cinnamomi 200g, Rhizoma Chuanxiong 150g, Herba Leonuri, 150g, Radix Linderae 150g, Rhizoma Zingiberis 150g, Colla Corii Asini 120g, Cortex Moutan 100g, Radix Bupleuri 150g, Fructus Aurantii 150g, Semen Persicae 150g, Flos Carthami 100g, Radix Paeoniae Alba 150g, Myrrha 100g, decoct with water 4 times, each 3 hours, collecting decoction, filter decocting liquid, clear paste filtrate being concentrated into relative density 1.32-1.37 at 24 DEG C is cooled to room temperature, add the ethanol of 80% of 7 times amount, filter, ethanol is reclaimed from filtrate, filtrate cold drying after ethanol will be reclaimed, pulverize, add appropriate pharmaceutically acceptable carrier, this pharmaceutically acceptable carrier is dextrin and protein sugar, ratio is: 1.2:0.3, granulate after mix homogeneously, cold drying, granulate, packaging, obtain compositions of the present invention, it is Capsule form.The capsule good drug efficacy prepared by this technique, and features good taste.
The dose of this capsule can be decided according to the state of an illness of patient by doctor.Usual adult takes this capsule 6g/ time, 3 times/day.
Here is research to Chinese medicine composition pharmacodynamics of the present invention and explanation:
Test 1: the present invention is on the impact of Mouse Uterus
Choose cleaning grade Kunming female mice 40, body weight 18-22g, be divided into 5 groups, often organize 8.Often organize corresponding medicament to be respectively: 1 group: the embodiment of the present invention 2 prepare tablet (1.4g/kg), 2 groups: TIANQI TONGJING JIAONANG (1.5g/kg), 3 groups: the method being 93118727 patent disclosure according to the application number of contrast prepare extractum (1.30g/kg), 4 groups: the method announced according to paper " from intending Pericarpium Citri Reticulatae Viride Rhizoma Cyperi Rhizoma Corydalis loose treatment dysmenorrhea 47 example " prepare crude drug extractum (1.36g/kg), blank group.
Each group of mice to be can't help in fasting under the condition of water 24 hours, and inject diethylstilbestrol 1ml respectively, when testing, to continue under the condition of water is can't help in fasting 12 hours, the urethane intravenous injection with 20% is anaesthetized, and face upward position and be fixed on operating-table, along midline abdominal incision under xiphoid-process, find out duodenum, insert conduit, purse string suture, fixing.On pubic symphysis, 3-4 centimetre median incision is done at place again, separating uterus, connects dull and stereotyped monitor record uterine activity by Uterus in vivo pendency method by tonotransducer.After stablizing 30 minutes, start to record uterine activity.Adopt duodenal administration, by each group of administration respectively, use isopyknic normal saline for blank group, administration starts after 30 minutes to record 30,60,90 minutes frequency of uterine contraction, amplitude, energies (frequency × amplitude).The experimental calculation result of the energy that mice is final the results are shown in Table 1.
Each group of table 1 is on the impact of normal Mouse Uterus energy
As shown in Table 1, the energy of the present invention to Mouse Uterus has and reduces effect significantly.
Above-mentioned each group of administration be after 100 minutes, often only little pika intramuscular injection oxytocin 5U, records the uterotonic frequency of every 10min, amplitude and energy.On normal uterine contraction and the impact resisting oxytocin after observation medication.Result shows 1 group of-4 group and all can resist the mice Uterus in vivo that oxytocin causes and shrink potentiation, and compare with blank group and have significant difference, experimental result sees the following form 2.
Table 2 resists the impact that oxytocin causes rabbit Uterus in vivo contraction movement
The equipment used in preparation method of the present invention is the common equipment of field of medicaments, does not repeat them here.
The foregoing is only the schematic detailed description of the invention of the present invention, and be not used to limit scope of the present invention.Any those skilled in the art, equivalent variations done under the prerequisite not departing from design of the present invention and principle and amendment, all should belong to the scope of protection of the invention.
Claims (6)
1. treat the Chinese medicine composition of the raw type dysmenorrhea of yang deficiency for one kind, it is characterized in that, said composition is prepared from by the raw material of following weight portion and pharmaceutically acceptable carrier: corydalis tuber 15-25 part, Radix Angelicae Sinensis 15-25 part, Ramulus Cinnamomi 10-20 part, Rhizoma Chuanxiong 10-15 part, Herba Leonuri 10-15 part, Radix Linderae 5-15 part, Rhizoma Zingiberis 5-15 part, Colla Corii Asini 6-12 part, Cortex Moutan 5-10 part, Radix Bupleuri 5-15 part, Fructus Aurantii 5-15 part, Semen Persicae 5-15 part, Flos Carthami 5-10 part, Radix Paeoniae Alba 10-15 part, Myrrha 5-10 part.
2. a kind of Chinese medicine composition for the treatment of the raw type dysmenorrhea of yang deficiency according to claim 1, it is characterized in that, said composition is prepared from by the raw material of following weight portion and pharmaceutically acceptable carrier: corydalis tuber 20 parts, Radix Angelicae Sinensis 20 parts, Ramulus Cinnamomi 15 parts, Rhizoma Chuanxiong 12.5 parts, Herba Leonuri 12.5 parts, the Radix Linderae 10 parts, Rhizoma Zingiberis 10 parts, 9 parts, Colla Corii Asini, Cortex Moutan 7.5 parts, Radix Bupleuri 10 parts, Fructus Aurantii 10 parts, 10 parts, Semen Persicae, 7.5 parts, Flos Carthami, the Radix Paeoniae Alba 12.5 parts, Myrrha 7.5 parts.
3. a kind of Chinese medicine composition for the treatment of the raw type dysmenorrhea of yang deficiency according to claim 1 and 2, is characterized in that: described compositions is tablet, capsule, granule, oral liquid, pill.
4. a kind of Chinese medicine composition for the treatment of the raw type dysmenorrhea of yang deficiency according to claim 1 and 2, is characterized in that, be prepared from by following steps:
(1) take corydalis tuber by weight respectively, Radix Angelicae Sinensis, Ramulus Cinnamomi, Rhizoma Chuanxiong, Herba Leonuri, the Radix Linderae, Rhizoma Zingiberis, Colla Corii Asini, Cortex Moutan, Radix Bupleuri, Fructus Aurantii, Semen Persicae, Flos Carthami, the Radix Paeoniae Alba, Myrrha are for subsequent use;
(2) medical material in step (1) is decocted with water 2-4 time, each 2-3 hour, collecting decoction;
(3) filter above-mentioned decocting liquid, clear paste filtrate being concentrated into relative density 1.32-1.35 at 24-40 DEG C is cooled to room temperature;
(4) add alcohol reflux 2-6 time of the 70-80% of 4-7 times amount, filter, from filtrate, reclaim ethanol;
(5) the rear cold drying of ethanol mixing of will reclaim, pulverize, add pharmaceutically acceptable carrier, mixing, makes medicament.
5. a kind of Chinese medicine composition for the treatment of the raw type dysmenorrhea of yang deficiency according to claim 1-2, is characterized in that: described pharmaceutically acceptable carrier is selected from one or more in filler, binding agent, disintegrating agent, lubricant, surfactant or correctives.
6. a kind of application of Chinese medicine composition in the medicine of preparation treatment dysmenorrhea for the treatment of the raw type dysmenorrhea of yang deficiency according to claim 1-2.
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| CN102886036A (en) * | 2012-10-12 | 2013-01-23 | 孙丽 | Traditional Chinese medicine for treating syndrome of congealing cold with blood stasis type dysmenorrheal disease |
| CN103251751A (en) * | 2013-06-06 | 2013-08-21 | 河北奥星集团药业有限公司 | Traditional Chinese medicine composition for treating primary dysmenorrheal and preparation method thereof |
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2015
- 2015-11-19 CN CN201510798491.3A patent/CN105233235A/en active Pending
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| CN1565553A (en) * | 2003-06-18 | 2005-01-19 | 薛永新 | Dysmenorrhea treating Chinese traditional medicine |
| WO2007113855A1 (en) * | 2006-03-30 | 2007-10-11 | Council Of Scientific & Industrial Research | A bioactive fraction from zingiber officinale and a process for the preparation thereof |
| CN102886036A (en) * | 2012-10-12 | 2013-01-23 | 孙丽 | Traditional Chinese medicine for treating syndrome of congealing cold with blood stasis type dysmenorrheal disease |
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