CN105229109B - Gelating agent - Google Patents
Gelating agent Download PDFInfo
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- CN105229109B CN105229109B CN201480029346.2A CN201480029346A CN105229109B CN 105229109 B CN105229109 B CN 105229109B CN 201480029346 A CN201480029346 A CN 201480029346A CN 105229109 B CN105229109 B CN 105229109B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
- A61K8/0229—Sticks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/02—Preparations containing skin colorants, e.g. pigments
- A61Q1/04—Preparations containing skin colorants, e.g. pigments for lips
- A61Q1/06—Lipsticks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/02—Preparations containing skin colorants, e.g. pigments
- A61Q1/08—Preparations containing skin colorants, e.g. pigments for cheeks, e.g. rouge
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K3/00—Materials not provided for elsewhere
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- Public Health (AREA)
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- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
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- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Cosmetics (AREA)
Abstract
The present invention, which is provided, can make the novel gelating agent of oleaginous base gelation well.The present invention relates to the gelating agent of the oleaginous base of the peptide compounds represented containing formula (1), the gel-form composition of the gelating agent containing (A) oleaginous base and (B) oleaginous base is further related to.Formula (1)：
Description
Technical field
The present invention relates to the gelating agent of oleaginous base.Further, and in particular to the oil containing specific peptide compounds
The gelating agent of property matrix.The present invention gelating agent liquid oleaginous base gelation will be rendered as under normal temperature so that its
It is useful in terms of form of diverseization.
Background technology
In the past, it is commonly known with 12- hydroxy stearic acids, Dextrin palmitate, two benzal as the gelating agent of oleaginous base
Base-D- D-sorbites are the aromatic aldehyde of representative and the condensation polymer etc. of polyalcohol.But these gelating agents have problems that：
In order that oleaginous base fully gelation, it is necessary to add gelating agent, the sense of touch that infringement oleaginous base has in large quantities
Deng.
On the other hand, in recent years, find using natural acid and amino acid as the Shuangzi of the hydrophilic group of 2 chain 3 of raw material
(gemini) type amphiphilic compound has oil-base gel formation function (with reference to patent document 1,2).The compound has peptide knot
Structure (includes 2 glutamic acid and 1 lysine), so that outside with oil-base gel formation function, also with excellent shield
Skin function, hair care function etc., are useful in these areas.In addition, the hobby day increased from a security point and in recent years
In terms of right tendency, the demand of the compound obtained for the material of the natural origin by amino acid, peptide etc. is also increasing.
Therefore there is the gelation of the oleaginous base of excellent gelatinization performance while demand has such peptide structure
Agent.
Prior art
Patent document
Patent document 1：Japanese Patent Laid-Open 2006-225403 publications
Patent document 2：Japanese Patent Laid-Open 2007-186498 publications
The content of the invention
The invention problem to be solved
The problem of the present invention can make the novel gelating agent of oleaginous base gelation well to provide.
The means to solve the problem
The present inventors uses for reference and attentively studies above-mentioned problem, as a result finds that specific peptide compounds have excellent gel
Change performance, so as to complete the present invention.It is found that further astonishingly：The novel gelating agent can suppress by gel
The oleaginous base of change from the surface of gel-form composition leaching, so-called " sweating phenomenon " because of rheological parameters' change with time.
That is, the present invention includes in the following manner.
[1] a kind of gelating agent of oleaginous base, it contains the peptide compounds of formula (1) expression,
【Change 1】
[in formula (1), R1、R2a、R2bAnd R2cRespectively alkyl, a and b represent 0 or 2 integer, (a, b)=(0,
Or (a, b)=(2,0) 2).]
[2] gelating agent of oleaginous base as described above described in [1], wherein, R1For the alkyl of carbon number 3~21, R2a、
R2bAnd R2cThe respectively alkyl of carbon number 1~10.
[3] gelating agent of oleaginous base as described above described in [1] or [2], wherein, R1For 1- ethyl pentyl groups or 11
Alkyl, R2a、R2bAnd R2cIt is butyl.
[4] a kind of gel-form composition, it contains the gel of the oleaginous base any one of (A) above-mentioned [1]~[3]
Agent and (B) oleaginous base.
[5] gel-form composition as described above described in [4], wherein, (B) oleaginous base be selected from by silicone oil, ester oil, hydrocarbon,
1 kind or two or more in the group of higher alcohol and aliphatic acid composition.
[6] gel-form composition as described above described in [4] or [5], wherein, relative to the total amount of gel-form composition, (A)
Combined amount 0.01~20 mass % is calculated as with the amount of the peptide compounds represented by formula (1).
[7] gel-form composition as described above any one of [4]~[6], the gel-form composition is shaped as
It is bar-shaped.
[8] gel-form composition as described above any one of [4]~[7], the gel-form composition be antiperspirant,
Lipstick or lipstick.
Invention effect
The gelating agent of a small amount of oleaginous base of the invention of addition, so that it may so that oleaginous base gelation well, and
And, it can suppress so-called " sweating phenomenon " that oleaginous base is leached from the surface of gel-form composition.Further, since with peptide
Structure, can expect its excellent skin-protecting function, hair care function.
Embodiment
The gelating agent of the oleaginous base of the present invention contains specific peptide compounds.
Herein, " gelating agent " in this specification is to instigate liquid thickening until becoming gel or the material of solid-like
Or composition.The present invention is useful especially as the gelating agent for oil-based liquid (oleaginous base).
(peptide compounds)
The peptide compounds contained in the gelating agent of the oleaginous base of the present invention are the compound that formula (1) is represented.
Formula (1)：
【Change 2】
[in formula (1), R1、R2a、R2bAnd R2cRespectively alkyl, a and b represent 0 or 2 integer, (a, b)=(0,2)
Or (a, b)=(2,0).]
In formula (1), R1Represented alkyl can be straight chain or containing any of side chain, preferably carbon number 3~21
Alkyl.
Such alkyl can enumerate propyl group, isopropyl, butyl, isobutyl group, sec-butyl, the tert-butyl group, amyl group, sec-amyl, uncle
Amyl group, isopentyl, hexyl, heptyl, 1- ethyl pentyl groups, octyl group, 2- ethylhexyls, t-octyl, nonyl, isononyl, decyl, isodecyl
Base, undecyl, dodecyl, tridecyl, isotridecyl, myristyl, pentadecyl, cetyl, octadecyl,
Isooctadecane base, 2- heptylundecanoics base, eicosyl, heneicosyl etc..From effective gel strength can be assigned on a small quantity
From the viewpoint of, the more preferably alkyl of carbon number 5~17, the most preferably alkyl of further preferred carbon number 7~13,1- second
Base amyl group or undecyl.
In formula (1), R2a、R2b、R2cThe alkyl of expression can be straight chain or containing any of side chain, they can with identical,
Can also be different.R2a、R2b、R2cThe alkyl of the preferred carbon number 1~10 of alkyl of expression.
Such alkyl can enumerate methyl, ethyl, isopropyl, propyl group, butyl, isobutyl group, sec-butyl, the tert-butyl group, amyl group,
Sec-amyl, tertiary pentyl, isopentyl, hexyl, heptyl, octyl group, 2- ethylhexyls, t-octyl, nonyl, isononyl, decyl, isodecyl
Deng.From the viewpoint of it can assign effective gel strength on a small quantity, the more preferably alkyl of carbon number 3~6, further preferably
R2a、R2b、R2cThe alkyl of expression is butyl.
In formula (1), a and b represent 0 or 2 integer, (a, b)=(0,2) or (a, b)=(2,0).That is, a is 0
In the case of b be that 2, a is that b is 0 in the case of 2.
The peptide compounds that formula (1) is represented have asymmetric carbon on amino acid residue, but special provision is not based on being somebody's turn to do
The DL bodies ratio (D bodies/L bodies (mass/mass)) of asymmetric carbon.
The peptide compounds that formula (1) is represented can be according to natively known method, by N- acyl glutamic acids acid anhydride, glutamate
And alkanamine manufacture.
(gelating agent of oleaginous base)
In the present invention, the peptide compounds that directly can be represented using above-mentioned formula (1), or cetanol, tristearin can be added
The additive of the excipient of alcohol, stearic acid, solidified oil, solid paraffin etc. etc., so as to provide powdered oleaginous base
Gelating agent, in addition, foregoing peptide compounds is dissolved or is suspended in the solvent of ethanol, isopropanol, DPG etc., so that
The oleaginous base gelating agent of liquid or suspension can be provided.In addition, for the purpose of the present invention, preferably providing powder
The form of last shape.
The content preferably 0.1 of the peptide compounds represented relative to the gelating agent total amount of the oleaginous base of the present invention, formula (1)
The mass % of quality %~100 mass %, more preferably 1.0 mass %~100.
Can by the present invention oleaginous base gelating agent gelation oleaginous base, as long as cosmetics, quasi- medicine
Product (Japanese：The outer product of pharmaceuticals) in the oleaginous base that typically uses just be not particularly limited, can for example enumerate methyl polysiloxane,
It is high polymeric MAO polysiloxanes, polyoxyethylene-methyl polysiloxane copolymer, polyoxypropylene-methyl polysiloxane copolymer, poly-
(oxygen ethene, oxypropylene)-methyl polysiloxane copolymer, stearic epoxide methyl polysiloxane, stearoxyl trimethyl silane, first
Base hydride silicone, prestox polysiloxanes, decamethyl polysiloxanes, decamethylcyclopentaandoxane, the silica of prestox ring four
Alkane, tetrahydrochysene tetramethyl-ring tetrasiloxane, octamethylpolysiloxane, the siloxanes of ten diformazan basic ring six, methyl phenyl silicone, three
Methyl siloxane-based silicic acid, aminoethylaminopropyl siloxane-dimethylsiloxane copolymer, silanol-modified poly- silica
Alkane, alkoxy-modified polysiloxanes, fatty acid modified polysiloxanes, fluorine richness polysiloxanes, epoxy-modified polysiloxanes, alkane
The silicone oil of epoxide modified polyorganosiloxane PFPE, polyvinyl acetate dimethyl polysiloxane etc.；Myristyl myristate base
The sad hexyl last of the ten Heavenly stems ester of ester, lauric acid hexyl ester, decyl oleate, isopropyl myristate, dimethyl, glycerin monostearate, three -2-
Ethylhexanoic acid glyceride, diethyl phthalate, Tego-stearate, ketostearic acid monooctyl ester, benzoic acid alkyl base ester
Deng ester oil；The hydrocarbon of atoleine, polyisobutene, vaseline, saualane etc.；Hexadecanol, isooctadecane alcohol, laruyl alcohol, hexyl
The higher alcohol of decyl alcohol, octyldodecanol etc.；The aliphatic acid of isostearic acid, undecenoic acid, oleic acid etc.；Lanolin, also argali
The wax of hair fat, Brazil wax etc.；Mink oil, cupu oil, coconut oil, palm-kernel oil, camellia oil, sesame oil, castor oil, olive
The grease of oil etc.；Ethene-alpha-olefin-common low polymer etc..
The preferred silicone oil of oleaginous base, ester oil, hydrocarbon, the height being gelled by the gelating agent of the oleaginous base of the present invention
Level alcohol and aliphatic acid, more preferably silicone oil, ester oil, hydrocarbon and higher alcohol.
(gel-form composition)
The present invention further provides a kind of gel-form composition, it contains the peptide chemical combination that (A) is represented containing above-mentioned formula (1)
The gelating agent of the oleaginous base of thing and (B) oleaginous base.
(B) oleaginous base being contained in the gel-form composition of the present invention can enumerate the oleaginous base recorded above, can
With from these oleaginous bases select a kind or two or more use.
For the purposes of the present disclosure, preferably use selected from by silicone oil, ester oil, hydrocarbon, higher alcohol and Fatty acid compositions
1 kind in group or two or more, more preferably use a kind in the group being made up of silicone oil, ester oil, hydrocarbon and higher alcohol or
Person two or more.
The combined amount of the gelating agent of above-mentioned (A) oleaginous base in the gel-form composition of the present invention, as long as oiliness base
The combined amount that matter can be gelled just has no particular limits.From obtaining gel strength and the suppression of above-mentioned " sweating phenomenon "
From the viewpoint of the gel-form composition of excellent effect processed, relative to gel-form composition total amount, the gelation of (A) oleaginous base
The gauge for the peptide compounds that the lower limit of the combined amount (quality %) of agent is represented with above-mentioned formula (1), preferably 0.01 mass %, it is more excellent
Select 0.03 mass %, further preferred 0.05 mass %, more preferred 0.1 mass %.In addition, from obtaining, use feeling is excellent to coagulate
From the viewpoint of jelly composition, relative to gel-form composition total amount, the combined amount (matter of the gelating agent of (A) oleaginous base
Amount %) the gauge of peptide compounds that is represented with above-mentioned formula (1) of higher limit, preferably 20 mass %, more preferably 10 mass % enter one
Step preferably 7 mass %, more preferred 5 mass %, most preferably 3 mass %.
The combined amount of the oleaginous base of above-mentioned (B), as long as carrying out gelation, does not just have in the gel-form composition of the present invention
There is special limitation.From the viewpoint of being formed and keeping gel network, relative to gel-form composition total amount, the oiliness of (B)
The lower limit of the combined amount (quality %) of matrix preferably 10 mass %, more preferably 20 mass %, further preferred 30 mass %, more
Plus preferably 50 mass %, most preferably 70 mass %.From that can be effectively formed from the viewpoint of gel, relative to gel-form composition
Total amount, higher limit preferably 99.99 mass %, the more preferably 99.9 mass % of the combined amount (quality %) of the oleaginous base of (B), enters
One step preferably 99 mass %, more preferred 98 mass %.
In the gel-form composition of the present invention, various chelatings can be mixed in the range of the effect of the present invention is not damaged
Can be used in the common cosmetics of agent, antiperspirant actives composition, surfactant, various additives, various powders etc. into
Point.
In the present invention, gel-form composition refers to the gelating agent and (B) oleaginous base only by (A) oleaginous base in the narrow sense
The composition of composition, in addition, broadly referring to further also include the cosmetic as final products of above-mentioned various adding ingredients
Product, aromatic, quasi drug etc..
As the various chelating agents that can be mixed in the gel-form composition of the present invention, it is not particularly limited, preferably three
Ethylene tetra, 2- TTAs, TGA, tartaric acid, butanedioic acid, 8-hydroxyquinoline, pyridine -2,6- dicarboxyls
Acid, pyridine, 1,10- phenanthrolenes (1,10-phenanthroline), lactic acid, HQS, glycine, 2,
2 '-pyridine radicals ethylenediamine, aurin tricarboxyli acid (ATA), xylenol orange, 5-sulphosalicylic acid, salicylic acid, catechol -3,5- disulfonic acid
It is ester, 4,5- dihydroxy benzenes -1,3- disulfonic acid, 1,2- diaminocyclohexanes-N, N, N', N'- tetraacethyl, citric acid, oxalates, secondary
Nitrilotriacetic acid, ethylenediamine-N, N, N', N'- tetraacethyl, acetylacetone,2,4-pentanedione and their salt, can therefrom select a kind individually makes
With, but also two or more is used in combination.
The antiperspirant actives composition of the so-called gel-form composition that can be mixed in the present invention refers to by making skin strong
Shrink the composition of the generation so as to suppress sweat in ground.Can be enumerated as such antiperspirant actives composition make aluminium chloride, aluminium chloride,
Allantoin aluminium chloride, aluminum sulfate, zinc oxide, p-phenolsulfonic acid's zinc and by zirconium oxychloride and aluminium hydroxide and chlorination
Aluminium hydroxide reacts and manufactured obtained zirconium aluminium complex, and they can select a kind of exclusive use, but also two or more is used in combination.
The surfactant of the gel-form composition of the present invention can be mixed in, for example, can enumerate N- long chain acyl acidic ammonia
N- long acyls amino-acid salt, the N- long acyl-N- methyl Taurines of base hydrochlorate and N- long acyl neutral amino acid salt etc.
Salt, alkyl sulfate and its alkylene oxide adduct, fatty acid amide ether sulfate, the metal salt of aliphatic acid and weak base salt, sulphur
The anion surface active of base butanedioic acid system surfactant, alkylphosphonic and its alkylene oxide adduct, alkyl ether carboxylic acid etc.
Agent；Ether type surfactant, the alkylene oxide adduct of glyceride, the sorbitan of glycerin ether and its alkylene oxide adduct etc.
Etheric ester type surfactant, polyoxyalkylene fatty acid esters, glyceride, the fatty acid polyglycol glycerine of the alkylene oxide adduct of ester etc.
Ester type surfactant, APG class, the hydrogenated castor oil coke paddy ammonia of ester, sorbitan ester, sucrose fatty ester etc.
The non-ionic surface of the nitrogenous type surfactant of acid diesters and its ethylene oxide adduct and fatty acid alkanol amides etc. etc.
Activating agent；The aromatic series quaternary ammonium salt of quaternary ammonium salt, the benzalkonium salt of alkyl ammomium chloride, dialkylammonium chloride etc. etc., N- acyl groups essence
The cationic surfactant of propylhomoserin ester etc.；And the betaine type surface of alkyl carboxyl glycine betaine, alkyl amido betaine etc.
Activating agent, N, aminocarboxylic acid type surfactant, the 2- alkyl -1- hydroxyethyls -1- of N- dialkyl amido alkylen carboxylic acids etc.
The Imidazoline Surfactants of carboxymethyl group imidazolinium betaine etc., 3- (lauroyl amino)-N, N- dimethylpropanes-
Amphoteric surfactant of the amine oxide type surfactant of 1- amine n-oxides etc. etc. etc..
In the gel-form composition of the present invention, can select a kind individually to mix from above-mentioned surfactant, can also 2
Kind more than and with mix.
The various additives of the gel-form composition of the present invention can be mixed into, for example, can enumerate：Glycine, alanine,
The amino acids of serine, threonine, arginine, glutamic acid, aspartic acid, isoleucine, leucine, valine etc.；Glycerine,
The polyalcohol of ethylene glycol, 1,3 butylene glycol, propane diols, isoprene etc.；Polyaminoacid including polyglutamic acid, poly-aspartate
And its salt, polyethylene glycol, Arabic gum class, alginate, xanthans, hyaluronic acid, hyaluronate, chitin, chitosan,
Water-soluble chitosan, carbopol, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl-trimethyl ammonium chloride, polychloride diformazan
Methylene piperidines, polyvinylpyrrolidone derivative quaternary ammonium, cationized proteins, collagen analyte and its derivative
The water soluble polymer of thing, acylated protein, polyglycereol etc.；The sugar alcohol and its alkylene oxide adduct of mannitol etc.；Ethanol, third
Outside lower alcohol of alcohol etc. etc., animals and plants extract, nucleic acid, vitamin, enzyme, antiinflammatory, bactericide, anti-corrosion can also be enumerated
Agent, antioxidant, ultra-violet absorber, pigment, color lake, oxidation dye, pH adjusting agent, pearling agent, wetting agent etc..
In the present invention, as needed, a kind in above-mentioned additive can be selected or 2 used above.
As various powders, resin powder, fatty acid metal such as can enumerate nylon powder, nylon beads, silicone pearl
The organic powder of the acylamino acid of soap, acyl-lysine, acyl glutamic acid, acyl group arginine, acylglycine etc. etc.；Yellow oxygen
Change iron, red ferric oxide, Black Rouge, chromium oxide, cobalt oxide, carbon black, ultramarine, Prussian blue, zinc oxide, titanium oxide, zirconium oxide,
Silica, aluminum oxide, cerium oxide, mica titanium, boron nitride, barium sulfate, calcium carbonate, magnesium carbonate, alumina silicate, magnesium silicate, carborundum,
Sericite, mica, talcum, kaolin, tabular barium sulfate, butterfly-shaped barium sulfate, particulate titanium dioxide, particulate oxide zinc, particulate oxide
The inorganic pigment of iron etc., they can also further implement silicone-treated, fluorine compounds processing, silane coupler processing, silane
Handle organic titanate processing, be acylated lysine processing, fatty acid treatment, metallic soap processing, finish processing, amino acid treatment
Deng surface treatment.
In the present invention, as needed, can select in above-mentioned powder a kind or more than 2.
There is no particular limitation for the shape of the gel-form composition of the present invention, can be with the semisolid of pasty state, creaminess etc.
The shape of the solid-like of shape, graininess, bar-shaped, spherical, membranaceous etc. is provided, and is particularly preferably provided with bar-shaped shape.
The gel-form composition of the present invention is prepared by following method：The gelating agent of (A) oleaginous base is added into
(B) in oleaginous base, dissolve by heating, other adding ingredients are added as needed, after uniform mixing, bottle, jar etc. are packed into
Container or model with the shape desired by bar-shaped grade in, be then cooled to room temperature.
In addition, the oil droplet that granular gel-form composition can be emulsified by the crushing of the gel of solidification, in aqueous phase
Gelation etc. prepare.
The present invention further provide containing above-mentioned gel-form composition of the invention or its own to be of the invention
The cosmetics or quasi drug of gel-form composition.
The present invention cosmetics or quasi drug do not limit shape and size, specifically can as antiperspirant, wash one's face
Articles for use, makeup removing gel, emulsion, massage cream, cold cream, moisture-retention gel, facial mask, gel after palpus, vanishing cream, lipstick, lipstick, rouge,
Mascara, shampoo, conditioner, preparation for baldness, hair-care essence, hair conditioner, bar-shaped hair oil, design-shaping gel (セ ッ ト ロ ー シ ョ Application),
Hair-cream, pomade, hair mousse, agent for permanent hair waving, hair dye, oxide hair dye (ヘ ア カ ラ ー), acidic hair coloring preparation (ヘ ア マ ニ キ
ュ ア), sunblock lotion, hand cleanser, aromatic and wet-dressing medicine etc. be provided, preferably as the tool of antiperspirant, lipstick or lipstick etc.
The cosmetics or quasi drug for having bar-shaped shape are provided.
Embodiment
Then, according to embodiment, the present invention will be described in more detail, but the invention is not limited in following implementation
Example.
The synthesis of [synthesis example 1] peptide compounds
The peptide compounds that synthesis type (2) is represented as described below.
Formula (2)：
【Change 3】
[in formula (2), a and b represent 0 or 2 integer, (a, b)=(0,2) or (a, b)=(2,0).]
＜ synthetic methods ＞
N- lauroyls-Pidolidone acid anhydride 31.1g (0.1mol) is added in 400mL toluene, stirs molten at 95 DEG C
Solution.Sodium glutamate monohydrate 18.7g (0.1mol) is added thereto, after being heated to reflux stirring 5 hours, is let cool to room temperature.With
The concentrated sulfuric acid makes its pH be 1, filters the solid separated out, dries, obtains 30.6g solid (yield 67%).Then, it will obtain
Solid 30.6g (0.067mol) is suspended in methanol 300mL, add concentrated sulfuric acid 0.66g (0.0067mol), carry out 5 hours plus
Hot return stirring.Then, lower distillation for removing methanol is depressurized, butylamine 49g (0.67mol) is added, 5 is heated to reflux to the solution again
Hour.The butylamine of surplus is distilled off under decompression, is washed with water after residue, is purified with chromatography, obtain target product 41.8g
(yield 50%).
NMR：1H-NMR peaks (CD3OD)δ：0.90-0.97 (m, 12H), 1.31-1.40 (m, 22H), 1.45-1.55 (m,
6H), 1.55-1.70 (m, 2H), 1.80-2.22 (m, 4H), 2.24-2.38 (m, 6H), 3.16-3.22 (m, 6H), 4.18-4.38
(m, 2H)
NMR condition determinations：Using nuclear magnetic resonance device (BRUKER Co. Ltd. systems, AVANCE 400), with tetramethylsilane
The peak of alkane is measured as 0ppm.
The evaluation ＞ of the gelating agent of ＜ oleaginous bases
[gelatinisation ability]
Table is added respectively into cyclopentasiloxane/octyldodecanol (80/20 (mass ratio) mixture) [(B) composition] 6g
The gelating agent of each oleaginous base of embodiment 1 and comparative example 1~3 shown in 1, becomes 1 mass %, is put into 30mL's
In sample phial, dissolve by heating.After dissolving, in 25 DEG C of standing at room temperature 24 hours, gel-form composition is obtained.Use rheometer
(FUDOH RHEO METER NRM-2010-J-CW) determines the gel strength of obtained gel-form composition, is commented based on following
Valency benchmark evaluation gelatinisation ability.Adapter uses plume (プ ル ー system) used with viscoplasticity, 10 φ, sample stage speed takes
6cm/min.As a result it is shown in table 1.
<Metewand>
○：Gel strength is more than 30g
△：Gel strength is more than 1g less than 30g
×：Non- gelation
[inhibitory action of sweating phenomenon]
With as described above the step of obtain gel-form composition, visually observe in obtained gel-form composition " hair
Sweat phenomenon ", i.e. oleaginous base are from the presence or absence of generation of surface bleeding of gel-form composition, based on following metewand
Assess the inhibitory action of sweating phenomenon.As a result it is shown in table 1.
<Metewand>
○：Have not seen sweating phenomenon
×：See sweating phenomenon
In addition, (A) composition and (B) composition that are used in this experiment are as follows.
(i) dilauroyl glutamic acid lysine sodium：Asahi Chemical Corp's system, " Pellicer L-30 " (ペ リ
セ ア L-30)
(ii) Dextrin palmitate：Chiba Flour Milling Co., Ltd.'s system, " Rheopearl LK2 " (レ オ パ ー Le LK2)
(iii) 12- hydroxy stearic acids：Tokyo HuaCheng Industry Co., Ltd's system, chemical reagent
(iv) cyclopentasiloxane：Dong Li DOW CORNINGs Co., Ltd. (East レ ダ ウ U ー ニ Application グ Co., Ltd.) makes,
“SH 245”
(v) octyldodecanol：(higher alcohol Industrial Co., Ltd system, " Risonol 20SP " (リ ソ ノ ー Le 20SP))
【Table 1】
*："-" is represented due to the non-gelation of composition, therefore not it is observed that sweating phenomenon in table.
As shown in table 1, the gelating agent of the oleaginous base of 1 mass % of addition embodiments of the invention 1, it is possible to formed
In gel with abundant intensity, the gel-form composition containing it, sweating phenomenon is suppressed.
On the other hand, in the case of the gelating agent (comparative example 1~3) of 1 mass % of addition existing oleaginous base, no
It can confirm that the formation of gel.
That is, the gelating agent of the oleaginous base of the invention of the peptide compounds containing synthesis example 1, with other existing oil
Property matrix gelating agent compare, a small amount of addition can make oleaginous base gelation, and be able to confirm that suppression " sweating is existing
As ".
Industrial applicability
According to the present invention it is possible to which oleaginous base gelation can just be made and can suppress " sweating by providing a small amount of addition
The gelating agent of the oleaginous base of phenomenon ".
In addition, the present invention can provide " sweating phenomenon " repressed good gel-form composition.
Patent 2013-106604 (the applying date of the application to apply in Japan：On May 20th, 2013) based on, this
Its whole content is included in specification.
Claims (17)
1. a kind of gelating agent of oleaginous base, it contains the peptide compounds of formula (1) expression,
【Change 1】
In formula (1), R1、R2a、R2bAnd R2cRespectively alkyl, a and b represent 0 or 2 integer, (a, b)=(0,2) or (a,
B)=(2,0).
2. the gelating agent of oleaginous base as claimed in claim 1, wherein, R1For the alkyl of carbon number 3~21, R2a、R2b
And R2cThe respectively alkyl of carbon number 1~10.
3. the gelating agent of oleaginous base as claimed in claim 1 or 2, wherein, R1For 1- ethyl pentyl groups or undecyl,
R2a、R2bAnd R2cIt is butyl.
4. a kind of gel-form composition, its contain (A) oleaginous base according to any one of claims 1 to 3 gelating agent,
And (B) oleaginous base.
5. gel-form composition as claimed in claim 4, wherein, (B) oleaginous base is selected from by silicone oil, ester oil, hydrocarbon, senior
1 kind or two or more in the group of alcohol and aliphatic acid composition.
6. the gel-form composition as described in claim 4 or 5, wherein, relative to the total amount of gel-form composition, (A) gel
The combined amount of agent is calculated as 0.01~20 mass % with the amount of the peptide compounds represented by formula (1).
7. gel-form composition as claimed in claim 4, being shaped as the gel-form composition is bar-shaped.
8. gel-form composition as claimed in claim 5, being shaped as the gel-form composition is bar-shaped.
9. gel-form composition as claimed in claim 4, the gel-form composition is antiperspirant, lipstick or lipstick.
10. gel-form composition as claimed in claim 5, the gel-form composition is antiperspirant, lipstick or lipstick.
11. gel-form composition as claimed in claim 7, the gel-form composition is antiperspirant, lipstick or lipstick.
12. gel-form composition as claimed in claim 8, the gel-form composition is antiperspirant, lipstick or lipstick.
13. the peptide compounds that a kind of formula (1) represents,
【Change 2】
In formula (1), R1、R2a、R2bAnd R2cRespectively alkyl, a and b represent 0 or 2 integer, (a, b)=(0,2) or (a,
B)=(2,0).
14. peptide compounds as claimed in claim 13, wherein, R1For the alkyl of carbon number 3~21, R2a、R2bAnd R2cPoint
Not Wei carbon number 1~10 alkyl.
15. the peptide compounds as described in claim 13 or 14, wherein, R1For 1- ethyl pentyl groups or undecyl, R2a、R2b
And R2cIt is butyl.
16. the peptide compounds as described in claim 13 or 14, wherein, R1For undecyl, R2a、R2bAnd R2cIt is butyl.
17. peptide compounds as claimed in claim 15, wherein, R1For undecyl, R2a、R2bAnd R2cIt is butyl.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013-106604 | 2013-05-20 | ||
| JP2013106604 | 2013-05-20 | ||
| PCT/JP2014/063237 WO2014189014A1 (en) | 2013-05-20 | 2014-05-19 | Gellant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105229109A CN105229109A (en) | 2016-01-06 |
| CN105229109B true CN105229109B (en) | 2017-07-28 |
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ID=51933567
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480029346.2A Active CN105229109B (en) | 2013-05-20 | 2014-05-19 | Gelating agent |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9597275B2 (en) |
| EP (1) | EP3000858B1 (en) |
| JP (1) | JP6292230B2 (en) |
| KR (1) | KR102181705B1 (en) |
| CN (1) | CN105229109B (en) |
| WO (1) | WO2014189014A1 (en) |
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| WO2016080248A1 (en) | 2014-11-20 | 2016-05-26 | 株式会社ダイセル | Thickening and stabilizing agent, and thickening and stabilizing composition using same |
| WO2016104697A1 (en) * | 2014-12-25 | 2016-06-30 | 味の素株式会社 | Cosmetic composition for use on hair and containing an acyl basic amino acid derivative |
| WO2016104696A1 (en) * | 2014-12-25 | 2016-06-30 | 味の素株式会社 | Cosmetic composition containing acyl basic amino acid derivative and inorganic powder |
| CN107890431B (en) * | 2017-11-30 | 2020-09-29 | 花安堂生物科技集团有限公司 | Oil gelling agent formula and scrub cream composition |
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| WO2004105707A1 (en) * | 2003-05-28 | 2004-12-09 | Ajinomoto Co. Inc. | Oil based gel composition |
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| US20020159961A1 (en) * | 2001-02-13 | 2002-10-31 | Ajinomoto Co. Inc. | Gelling agent for oil |
| US20050208085A1 (en) * | 2002-06-03 | 2005-09-22 | Ajinomoto Co. Inc | Gelling agent |
| WO2004096754A1 (en) | 2003-04-28 | 2004-11-11 | Ajinomoto Co., Inc. | Two-headed basic amino acid derivative |
| JP4953691B2 (en) | 2005-06-17 | 2012-06-13 | 旭化成ケミカルズ株式会社 | Oily gel cleansing |
| JP2007186498A (en) | 2006-12-01 | 2007-07-26 | Asahi Kasei Chemicals Corp | Oily gel-like composition |
-
2014
- 2014-05-19 KR KR1020157035659A patent/KR102181705B1/en active IP Right Grant
- 2014-05-19 JP JP2015518239A patent/JP6292230B2/en active Active
- 2014-05-19 EP EP14801229.7A patent/EP3000858B1/en active Active
- 2014-05-19 WO PCT/JP2014/063237 patent/WO2014189014A1/en active Application Filing
- 2014-05-19 CN CN201480029346.2A patent/CN105229109B/en active Active
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|---|---|---|---|---|
| JP2000044554A (en) * | 1998-07-31 | 2000-02-15 | Asahi Denka Kogyo Kk | Amino acid anhydride and its production and production of amino acid derivative |
| CN1659251A (en) * | 2002-06-03 | 2005-08-24 | 味之素株式会社 | Gellant |
| WO2004105707A1 (en) * | 2003-05-28 | 2004-12-09 | Ajinomoto Co. Inc. | Oil based gel composition |
| JP2005281292A (en) * | 2004-03-01 | 2005-10-13 | Kao Corp | Amide compound |
| JP2005298388A (en) * | 2004-04-09 | 2005-10-27 | Shiseido Co Ltd | Gel composition and method for producing the same |
| CN101365415A (en) * | 2006-01-06 | 2009-02-11 | 味之素株式会社 | Gelling agent |
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| CN101743289A (en) * | 2007-07-05 | 2010-06-16 | 日产化学工业株式会社 | Novel lipid-tripeptide based hydrogel-forming agent and hydrogel |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3000858B1 (en) | 2019-02-13 |
| EP3000858A1 (en) | 2016-03-30 |
| JP6292230B2 (en) | 2018-03-14 |
| JPWO2014189014A1 (en) | 2017-02-23 |
| KR102181705B1 (en) | 2020-11-23 |
| CN105229109A (en) | 2016-01-06 |
| US9597275B2 (en) | 2017-03-21 |
| KR20160010562A (en) | 2016-01-27 |
| EP3000858A4 (en) | 2016-10-19 |
| US20160074304A1 (en) | 2016-03-17 |
| WO2014189014A1 (en) | 2014-11-27 |
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