CN105213983A - A kind of preparation method for the treatment of the Chinese medicinal composition capsules of eczema - Google Patents
A kind of preparation method for the treatment of the Chinese medicinal composition capsules of eczema Download PDFInfo
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Abstract
The present invention relates to a kind of preparation method for the treatment of the Chinese medicinal composition capsules of eczema: (1) prepares Chinese medical concrete: described Chinese medical concrete by following weight portion each medical material through decoct, filter, concentrated acquisition: Herba Pogostemonis 8-15 part, Fructus Amomi 8-12 part, parching to brown Siberian cocklebur 10-20 part, Radix Curcumae 10-18 part, Massa Medicata Fermentata 5-12 part, Radix Polygalae (processed) meat 6-15 part, Herba Eupatorii 8-12 part, Fructus Amomi Rotundus 8-12 part, Rhizoma Dioscoreae Septemlobae 10-18 part, fry Fructus Oryzae Germinatus 12-16 part, Endothelium Corneum Gigeriae Galli (parched) 8-12 part, Rhizoma Acori Graminei 10-16 part, Semen Coicis 25-35 part, Herba Taraxaci 20-40 part, Fructus Toosendan (parched) 8-15 part, Fructus Hordei Germinatus (parched) 10-15 part, Stigma Maydis 25-40 part, the moisture content of described Chinese medical concrete is 40-50%, (2) preparation of Chinese medicine leaching powder, (3) fill of Chinese medicinal composition capsules.Beneficial effect of the present invention: <b>(</bGreatT.Gr eaT.GT<b>1</bGre atT.GreaT.GT<b>) </b> clinical trial finds that therapeutic effect is good, treatment Splenic asthenia and obstruction of dampness eczema effective percentage is up to 80%; (2) the present invention soaks powder by lixiviate, concentrated, dry acquisition, and then fill becomes capsule, taking convenience, and mouthfeel is also improved greatly.
Description
Technical field
The present invention relates to a kind of Chinese medicinal composition capsules, relate to a kind of preparation method for the treatment of the Chinese medicinal composition capsules of eczema specifically.
Background technology
Splenic asthenia and obstruction of dampness eczema is a kind of scytitis reaction of the acute pruritus caused by multiple internal and external factor, western medical treatment mainly uses antihistaminic antipruritic, also can oral or injection glucocorticoid, but the large and unsuitable life-time service of side effect, draw through present inventor's practice, Chinese medicine is controlled spleen asthenia and dampness retention and then is had good effect to Splenic asthenia and obstruction of dampness eczema, spleen asthenia and dampness retention is a disease type of the traditional Chinese medical science, spleen system has the function of transmitting and distributing the fluids under normal circumstances, body water liquid is normally run, is unlikely to stagnation and forms wet.When insufficiency of the spleen, the miopragia of its transformation of body flaud, water liquid is easily stagnated into wet, and wet Sheng can affect the recovery of splenic function conversely.Clinical manifestation show as more extremity acid heavy unable, vexed, the large loose stool of poor appetite, gastral cavity abdomen painful abdominal mass is thin, spiritlessness and weakness, anorexia is greasy, and light red tongue is fat, greasy and thin fur, the dampness syndromes such as relaxed and soft pulse.Treatment will invigorating the spleen for eliminating dampness, helps with diuresis, and making wetly has outlet, goes from urine.Spleen asthenia and dampness retention easily causes dyspepsia, shortness of breath and fatigue, the situation of diarrhea.
Summary of the invention
The object of the present invention is to provide a kind of method for the treatment of the Chinese medicinal composition capsules of eczema, by choose reasonable medical material and reasonable compatibility, make capsule, reach the object for the treatment of Splenic asthenia and obstruction of dampness eczema safely and efficiently.
The technical scheme that the present invention solves the employing of its technical problem is as follows:
Treat a preparation method for the Chinese medicinal composition capsules of eczema, described preparation method step is as follows:
(1) prepare Chinese medical concrete: described Chinese medical concrete by following weight portion each medical material through decoct, filter, concentrated acquisition: Herba Pogostemonis 8-15 part, Fructus Amomi 8-12 part, parching to brown Siberian cocklebur 10-20 part, Radix Curcumae 10-18 part, Massa Medicata Fermentata 5-12 part, Radix Polygalae (processed) meat 6-15 part, Herba Eupatorii 8-12 part, Fructus Amomi Rotundus 8-12 part, Rhizoma Dioscoreae Septemlobae 10-18 part, fry Fructus Oryzae Germinatus 12-16 part, Endothelium Corneum Gigeriae Galli (parched) 8-12 part, Rhizoma Acori Graminei 10-16 part, Semen Coicis 25-35 part, Herba Taraxaci 20-40 part, Fructus Toosendan (parched) 8-15 part, Fructus Hordei Germinatus (parched) 10-15 part, Stigma Maydis 25-40 part, the moisture content of described Chinese medical concrete is 40-50%,
(2) preparation of Chinese medicine leaching powder: the Chinese medical concrete that step (1) obtains is mixed with appropriate amount of auxiliary materials, then through the Chinese medicine leaching powder of super-dry, pulverizing, screening acquisition moisture content≤0.5%, the weight portion of Chinese medical concrete and adjuvant is composed as follows: Chinese medical concrete 50-60 part, mannitol 20-30 part, micropowder silica gel 10-15 part, the mass ratio of mannitol and micropowder silica gel is 2:1;
(3) fill of Chinese medicinal composition capsules: Chinese medicine leaching powder fill step (2) obtained, in hungry area softgel shell, obtains Chinese medicinal composition capsules.
The effect of the Chinese crude drug selected in the present invention is as follows:
Herba Pogostemonis: for turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is vomitted, heat-damp in summer exterior syndrome, hygropyrexia from the beginning of, heating asthenia, uncomfortable in chestly do not relax, cold-damp closes summer-heat, and stomachache is vomited and diarrhoea, nasosinusitis headache.
Fructus Amomi: there is removing dampness appetizing, warming spleen and stopping diarrha, antiabortive function of regulating the flow of vital energy.
Radix Scutellariae: antibacterial, antiviral, antiinflammatory, on the impact of immunologic function, antipyretic.
Radix Curcumae: regulating qi to disperse stagnation, heart fire-clearing upset-relieving.
Massa Medicata Fermentata: invigorating the spleen and regulating the stomach, promoting digestion and removing stagnation.Cure mainly the diseases such as retention of food and drink, dyspepsia, distension and fullness in the abdomen, inappetence, vomiting dysentery.
Radix Polygalae (processed) meat: the function of there is Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, subsiding a swelling, the insomnia and dreamful sleep caused for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells.
Herba Eupatorii: removing dampness by means of aromatics, appetizing of being amusing, delivers expelling summer-heat.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass vomiting and nausea, sweet greasy in mouth, halitosis, sialism, heat-damp in summer table disease, feeling of fullness in the head is uncomfortable in chest.
Fructus Amomi Rotundus: removing dampness circulation of qi promoting, warming middle-JIAO to arrest vomiting, appetite-stimulating indigestion-relieving.For retention of dampness in middle-JIAO, anorexia, hygropyrexia from the beginning of, uncomfortable in chest not hungry, cold-damp vomiting, chest and abdomen swelling and pain, food stagnation does not disappear.
Rhizoma Dioscoreae Septemlobae: have dampness removing to go turbid, effect of wind expelling stagnation removing.
Fry Fructus Oryzae Germinatus: food stagnation does not disappear, abdominal distention, insufficiency of the spleen lack of appetite.
Endothelium Corneum Gigeriae Galli (parched): invigorating the stomach and promoting digestion, arresting seminal emission.
Rhizoma Acori Graminei: removing dampness is whetted the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.Not hungry for gastral cavity painful abdominal mass, a mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.Regulate the flow of vital energy, invigorate blood circulation, loose wind, dries.
Semen Coicis: dry except wind, clearing away heat and discharging pus, eliminating impediment pain relieving.
Herba Taraxaci: containing multiple health-nutrition compositions such as taraxol, taraxacin, choline, organic acid, inulin in Herba Taraxaci plant, nature and flavor are sweet, micro-hardship, cold, there are the effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting, control pyretic toxicity, carbuncle, skin infection, abscess of internal organ, conjunctival congestion and swelling pain, damp and hot, the puckery pain of jaundice, dribbling urination, furuncle swelling toxin, acute mastitis, scrofula, toothache, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.Control acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection etc.
Fructus Toosendan (parched): except damp and hot, clearing away liver-fire, pain relieving, parasite killing.
Fructus Hordei Germinatus (parched): can dispersing the stagnated live-QI to relieve the stagnation of QI, for the hypochondriac pain of irritability stasis or incoordination between the liver and stomach.
Stigma Maydis: have inducing diuresis to remove edema, effect of liver heat removing function of gallbladder promoting.
Present inventor finds in practice, the cause of disease of Splenic asthenia and obstruction of dampness eczema is complicated, inducement may be that psychentonia, vexed gas are hot-tempered, malaise, insomnia are depressed, stagnation of QI due to depression of the liver, dyspepsia and dominance of heat in the interior and trace element deficiency etc., therefore treatment Splenic asthenia and obstruction of dampness eczema is with invigorating the spleen for eliminating dampness, depressed liver-energy dispersing and QI regulating, in removing body, pyretic toxicity is breach, is aided with anti-inflammation, analgesia, to obtain therapeutic effect targetedly.Inventor have selected the above-mentioned all kinds of medicine composition compositions with pyretic toxicity and antibacterial analgesic efficacy in depressed liver-energy dispersing and QI regulating, removing body for this reason, for the treatment of Splenic asthenia and obstruction of dampness eczema, clinical trial finds that therapeutic effect is good, and orally taken for curing Splenic asthenia and obstruction of dampness eczema effective percentage is up to 80%.
Preferably, Chinese medical concrete described in step (1) is obtained through decocting, filtering, concentrate by each medical material of following weight portion:
Herba Pogostemonis 9 parts, Fructus Amomi 10 parts, parching to brown Siberian cocklebur 15 parts, Radix Curcumae 12 parts, Massa Medicata Fermentata 10 parts, Radix Polygalae (processed) meat 9 parts, Herba Eupatorii 9 parts, 9 parts, Fructus Amomi Rotundus, Rhizoma Dioscoreae Septemlobae 15 parts, fry Fructus Oryzae Germinatus 15 parts, Endothelium Corneum Gigeriae Galli (parched) 9 parts, Rhizoma Acori Graminei 12 parts, Semen Coicis 30 parts, Herba Taraxaci 30 parts, Fructus Toosendan (parched) 12 parts, Fructus Hordei Germinatus (parched) 15 parts, Stigma Maydis 30 parts.
Preferably, in step (2), the weight portion of Chinese medical concrete and adjuvant is composed as follows: Chinese medical concrete 55 parts, 24 parts, mannitol, micropowder silica gel 12 parts.
Beneficial effect of the present invention:
(1)by choose reasonable medical material and reasonable compatibility, make capsule for oral administration, reach the object for the treatment of Splenic asthenia and obstruction of dampness eczema safely and efficiently, clinical trial finds that therapeutic effect is good, and treatment Splenic asthenia and obstruction of dampness eczema effective percentage is up to 80%.
(2) decocting for Chinese herbal medicine liquid bitter in the mouth, amount is greatly, especially oral very inconvenient for the patient that the intestines and stomach is not good, affects therapeutic effect, and the present invention soaks powder by lixiviate, concentrated, dry acquisition, and then fill becomes capsule, taking convenience, and mouthfeel is also improved greatly.
(3) Chinese medical concrete is dried to Chinese medicine leaching powder process more difficult is recognized problem in industry, because Chinese medical concrete viscosity is large, after drying, very easily the moisture absorption is lumpd, and affects the fill of capsule, present inventor have selected excellent adjuvant for this reason, and determining suitable proportioning, nonhygroscopic caking in dry obtained Chinese medicine leaching powder 24 hours, outward appearance is good, good fluidity, the fill of very convenient capsule, not harsh to the requirement of filling environment, be convenient to suitability for industrialized production.
Detailed description of the invention
Below by embodiment, technical scheme of the present invention is described further.
embodiment 1:
Treat a preparation method for the Chinese medicinal composition capsules of eczema, described preparation method step is as follows:
(1) prepare Chinese medical concrete: described Chinese medical concrete by following weight portion each medical material through decoct, filter, concentrated acquisition: Herba Pogostemonis 8 parts, Fructus Amomi 8 parts, parching to brown Siberian cocklebur 10 parts, Radix Curcumae 10 parts, Massa Medicata Fermentata 5 parts, Radix Polygalae (processed) meat 6 parts, Herba Eupatorii 8 parts, 8 parts, Fructus Amomi Rotundus, Rhizoma Dioscoreae Septemlobae 10 parts, fry Fructus Oryzae Germinatus 12 parts, Endothelium Corneum Gigeriae Galli (parched) 8 parts, Rhizoma Acori Graminei 10 parts, Semen Coicis 25 parts, Herba Taraxaci 20 parts, Fructus Toosendan (parched) 8 parts, Fructus Hordei Germinatus (parched) 10 parts, Stigma Maydis 25 parts, the Chinese medicine composition of above-mentioned formula ratio is added the water of gross mass 5 times, normal pressure decocts 2-3 hour, the filtrate of filtering, vacuum concentration is to the Chinese medical concrete of moisture content 50%,
(2) preparation of Chinese medicine leaching powder: the Chinese medical concrete that step (1) obtains is mixed with appropriate amount of auxiliary materials, then through the Chinese medicine leaching powder of super-dry, pulverizing, screening acquisition moisture content≤0.5%, the weight portion of Chinese medical concrete and adjuvant is composed as follows: Chinese medical concrete 50 parts, 20 parts, mannitol, micropowder silica gel 10 parts;
(3) fill of Chinese medicinal composition capsules: Chinese medicine leaching powder fill step (2) obtained, in hungry area softgel shell, obtains Chinese medicinal composition capsules.
embodiment 2:
Treat a preparation method for the Chinese medicinal composition capsules of eczema, described preparation method step is as follows:
(1) prepare Chinese medical concrete: described Chinese medical concrete by following weight portion each medical material through decoct, filter, concentrated acquisition: Herba Pogostemonis 15 parts, Fructus Amomi 12 parts, parching to brown Siberian cocklebur 20 parts, Radix Curcumae 18 parts, Massa Medicata Fermentata 12 parts, Radix Polygalae (processed) meat 15 parts, Herba Eupatorii 12 parts, 12 parts, Fructus Amomi Rotundus, Rhizoma Dioscoreae Septemlobae 18 parts, fry Fructus Oryzae Germinatus 16 parts, Endothelium Corneum Gigeriae Galli (parched) 12 parts, Rhizoma Acori Graminei 16 parts, Semen Coicis 35 parts, Herba Taraxaci 40 parts, Fructus Toosendan (parched) 15 parts, Fructus Hordei Germinatus (parched) 15 parts, Stigma Maydis 40 parts, the Chinese medicine composition of above-mentioned formula ratio is added the water of gross mass 8 times, normal pressure decocts 2-3 hour, the filtrate of filtering, vacuum concentration is to the Chinese medical concrete of moisture content 60%,
(2) preparation of Chinese medicine leaching powder: the Chinese medical concrete that step (1) obtains is mixed with appropriate amount of auxiliary materials, then through the Chinese medicine leaching powder of super-dry, pulverizing, screening acquisition moisture content≤0.5%, the weight portion of Chinese medical concrete and adjuvant is composed as follows: Chinese medical concrete 60 parts, 30 parts, mannitol, micropowder silica gel 15 parts;
(3) fill of Chinese medicinal composition capsules: Chinese medicine leaching powder fill step (2) obtained, in hungry area softgel shell, obtains Chinese medicinal composition capsules.
embodiment 3:
Treat a preparation method for the Chinese medicinal composition capsules of eczema, described preparation method step is as follows:
(1) prepare Chinese medical concrete: described Chinese medical concrete by following weight portion each medical material through decoct, filter, concentrated acquisition: Herba Pogostemonis 9 parts, Fructus Amomi 10 parts, parching to brown Siberian cocklebur 15 parts, Radix Curcumae 12 parts, Massa Medicata Fermentata 10 parts, Radix Polygalae (processed) meat 9 parts, Herba Eupatorii 9 parts, 9 parts, Fructus Amomi Rotundus, Rhizoma Dioscoreae Septemlobae 15 parts, fry Fructus Oryzae Germinatus 15 parts, Endothelium Corneum Gigeriae Galli (parched) 9 parts, Rhizoma Acori Graminei 12 parts, Semen Coicis 30 parts, Herba Taraxaci 30 parts, Fructus Toosendan (parched) 12 parts, Fructus Hordei Germinatus (parched) 15 parts, Stigma Maydis 30 parts, the Chinese medicine composition of above-mentioned formula ratio is added the water of gross mass 7 times, normal pressure decocts 2-3 hour, the filtrate of filtering, vacuum concentration is to the Chinese medical concrete of moisture content 55%,
(4) preparation of Chinese medicine leaching powder: the Chinese medical concrete that step (1) obtains is mixed with appropriate amount of auxiliary materials, then through the Chinese medicine leaching powder of super-dry, pulverizing, screening acquisition moisture content≤0.5%, the weight portion of Chinese medical concrete and adjuvant is composed as follows: Chinese medical concrete 55 parts, 24 parts, mannitol, micropowder silica gel 12 parts;
(5) fill of Chinese medicinal composition capsules: Chinese medicine leaching powder fill step (2) obtained, in hungry area softgel shell, obtains Chinese medicinal composition capsules.
Beneficial effect of the present invention is further illustrated below in conjunction with clinical testing data:
1, present inventor collects 120 routine Splenic asthenia and obstruction of dampness eczema patients altogether year July in July, 2014 to 2015, wherein male 60 example, women 60 example, age 30-35 year, course of disease 1-2, above-mentioned 120 routine patients be divided at random two groups (experimental group and matched groups), two groups of sexes, age and courses of disease are without the significance difference opposite sex.
2, test method
Experimental group takes Chinese medicinal composition capsules of the present invention, three times on the one, each 2, serves completely a course for the treatment of.
Matched group: antihistaminic is taken in instruction to specifications, serves completely a course for the treatment of.
3, criterion of therapeutical effect:
Recovery from illness: clinical symptoms disappears completely; Take a turn for the better: clinical symptom relief, obviously improve; Invalid: clinical symptoms even increases the weight of without improvement.
4, experimental result
| Group | Recovery from illness | Take a turn for the better | Invalid | Untoward reaction | Cure rate |
| Experimental group | 48 | 12 | 0 | 0 | 80% |
| Matched group | 51 | 6 | 0 | 3 | 85% |
As can be seen from the result of upper table, the capsule that the present invention prepares for the cure rate of orally taken for curing Splenic asthenia and obstruction of dampness eczema up to 80%, suitable with matched group, good effect, and the appearance that has no adverse reaction.
Claims (3)
1. treat a preparation method for the Chinese medicinal composition capsules of eczema, it is characterized in that, described preparation method step is as follows:
(1) prepare Chinese medical concrete: described Chinese medical concrete by following weight portion each medical material through decoct, filter, concentrated acquisition: Herba Pogostemonis 8-15 part, Fructus Amomi 8-12 part, parching to brown Siberian cocklebur 10-20 part, Radix Curcumae 10-18 part, Massa Medicata Fermentata 5-12 part, Radix Polygalae (processed) meat 6-15 part, Herba Eupatorii 8-12 part, Fructus Amomi Rotundus 8-12 part, Rhizoma Dioscoreae Septemlobae 10-18 part, fry Fructus Oryzae Germinatus 12-16 part, Endothelium Corneum Gigeriae Galli (parched) 8-12 part, Rhizoma Acori Graminei 10-16 part, Semen Coicis 25-35 part, Herba Taraxaci 20-40 part, Fructus Toosendan (parched) 8-15 part, Fructus Hordei Germinatus (parched) 10-15 part, Stigma Maydis 25-40 part, the moisture content of described Chinese medical concrete is 40-50%,
(2) preparation of Chinese medicine leaching powder: the Chinese medical concrete that step (1) obtains is mixed with appropriate amount of auxiliary materials, then through the Chinese medicine leaching powder of super-dry, pulverizing, screening acquisition moisture content≤0.5%, the weight portion of Chinese medical concrete and adjuvant is composed as follows: Chinese medical concrete 50-60 part, mannitol 20-30 part, micropowder silica gel 10-15 part, the mass ratio of mannitol and micropowder silica gel is 2:1;
(3) fill of Chinese medicinal composition capsules: Chinese medicine leaching powder fill step (2) obtained, in hungry area softgel shell, obtains Chinese medicinal composition capsules.
2. the preparation method of the Chinese medicinal composition capsules for the treatment of eczema according to claim 1, it is characterized in that Chinese medical concrete described in step (1) is obtained through decocting, filtering, concentrate by each medical material of following weight portion: Herba Pogostemonis 9 parts, Fructus Amomi 10 parts, parching to brown Siberian cocklebur 15 parts, Radix Curcumae 12 parts, Massa Medicata Fermentata 10 parts, Radix Polygalae (processed) meat 9 parts, Herba Eupatorii 9 parts, 9 parts, Fructus Amomi Rotundus, Rhizoma Dioscoreae Septemlobae 15 parts, fry Fructus Oryzae Germinatus 15 parts, Endothelium Corneum Gigeriae Galli (parched) 9 parts, Rhizoma Acori Graminei 12 parts, Semen Coicis 30 parts, Herba Taraxaci 30 parts, Fructus Toosendan (parched) 12 parts, Fructus Hordei Germinatus (parched) 15 parts, Stigma Maydis 30 parts.
3. the preparation method of the Chinese medicinal composition capsules for the treatment of eczema according to claim 1, is characterized in that, in step (2), the weight portion of Chinese medical concrete and adjuvant is composed as follows: Chinese medical concrete 55 parts, 24 parts, mannitol, micropowder silica gel 12 parts.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101559184A (en) * | 2008-04-17 | 2009-10-21 | 北京汉潮联创中药科技有限公司 | Chinese materia medica preparation for treating eczema |
| CN101991794A (en) * | 2009-08-26 | 2011-03-30 | 栗素琴 | Chinese traditional medicine preparation for treating eczema |
| CN102343055A (en) * | 2011-09-28 | 2012-02-08 | 李军 | Traditional Chinese medicine composition for treating eczema |
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2015
- 2015-10-28 CN CN201510709937.0A patent/CN105213983A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101559184A (en) * | 2008-04-17 | 2009-10-21 | 北京汉潮联创中药科技有限公司 | Chinese materia medica preparation for treating eczema |
| CN101991794A (en) * | 2009-08-26 | 2011-03-30 | 栗素琴 | Chinese traditional medicine preparation for treating eczema |
| CN102343055A (en) * | 2011-09-28 | 2012-02-08 | 李军 | Traditional Chinese medicine composition for treating eczema |
Non-Patent Citations (3)
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| 傅佩骏: "湿疹临证辨治八法", 《山东中医杂志》 * |
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