CN105213727A - Chinese medicine composition being used for the treatment of scapulohumeral periarthritis and preparation method thereof - Google Patents
Chinese medicine composition being used for the treatment of scapulohumeral periarthritis and preparation method thereof Download PDFInfo
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Abstract
The invention provides a kind of Chinese medicine composition being used for the treatment of scapulohumeral periarthritis, its raw material components comprises the Radix Angelicae Dahuricae, Flos Carthami, Myrrha, Radix Gentianae Macrophyllae, Calculus Bovis, Moschus, Radix Notoginseng, Herba Epimedii, Olibanum, Rhizoma Homalomenae, Radix Paeoniae Rubra, Galla Chinensis, Radix Stephaniae Tetrandrae, Pheretima and Rhizoma Paridis.Its more existing treatment by Chinese herbs better can reduce the index of scapulohumeral periarthritis, improves the clinical sign of patient, prevents scapulohumeral periarthritis from worsening further, have no side effect simultaneously, has safety and the comfort of height.
Description
Technical field
The present invention relates to technical field of Chinese medicine, particularly relate to a kind of Chinese medicine composition being used for the treatment of scapulohumeral periarthritis and preparation method thereof.
Background technology
Scapulohumeral periarthritis is called for short scapulohumeral periarthritis, refers to the extensive chronic inflammatory reaction of the shoulder joint surrounding soft tissue such as shoulder joint and the muscle caused by surrounding soft tissue's degenerative change, tendon, synovial bursa, joint capsule.Its main feature is that shoulder pain and shoulder mobility like limit, is the commonly encountered diseases of middle-aged and elderly people, frequently-occurring disease.
Shoulder, elbow and cervical region joint are one of human body activities of daily living general positions widest in area, hard work is undertaken in daily productive labor, the chance turning round crushing wound is many, normal attack meridians because wind, cold, wet and outside are sprained and due to overwork, shoulder, elbow, cervical region joint be overworked for a very long period damage or the posture tolerance range exceeding the soft tissue such as shoulder muscle, tendon such as bad year in year out, produce muscle, tendon, ligament fibers trace repeatedly rupture and hemorrhage, thus form the aseptic inflammation of shoulder joint surrounding tissue, adhesion and contracture gradually.
The principal pathogenetic reason of scapulohumeral periarthritis is: shoulder surrounding soft tissue degenerative change, the invasion and attack of the damp that is affected by the cold, and the ligament around shoulder joint, tendon etc. are strain for a long time, and shoulder wound and shoulder activity reduce.Above reason can cause the acute and chronic aseptic inflammation reaction of shoulder joint surrounding soft tissue, oozes out, edema, with the passing of time then tendon, intracapsular adhesion, has influence on the functional activity in joint.The clinical manifestation of scapulohumeral periarthritis mainly contains: shoulder pain, tenderness, inconvenient activity, and hypnalgia is waken up sometimes, and can not oppress shoulder in bed, stage shows as shoulder joint adhesion, and movable function is obviously limited.Patient Chang Buneng hands at the back, comb one's hair, wear the clothes, undress, the action such as wash one's face.
Modern medicine and Chinese medicine are thought: scapulohumeral periarthritis is that rheumatism attacked by the cold and evil causes because shoulder from catching cold makes slow blood flow around shoulder joint, muscular tone spasm, long-term muscle spasm causes metabolite accumulation, nutrition can not arrive, then producing aseptic inflammation, then there is inflammatory adhesion, shoulder elbow joint pain, limitation of activity in of a specified duration; Being one of the common disease of modern handle official bussiness personage of long-time operation computor-keyboard, mouse, is also a kind of frequently-occurring disease.
Have medicine and the method for a lot of cure scapulohumeral periarthritis at present, the traditional Chinese medical science thinks that primary disease is caused by shoulder is affected by the cold, and its treatment is basic still based on blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain.Number of patent application be CN02127922.5 application discloses a kind of plaster for periarthritis of shoulder joint and preparation technology thereof, but its curative effect is not verified.Wu Haofeng has applied for again that in 2003 number of patent application is the plaster for periarthritis of shoulder joint of ZL200310111099.4 and the patent application of preparation technology thereof, and obtains mandate in 2006.As said in this patent, Chinese medicine is useful for some crowds, and it is not obvious to stress results for the others, so need to provide a greater variety of medicine to select for patient.
The present invention is based on the summary of experience of modern Chinese medicine pharmaceutical research and clinical case, in conjunction with motherland's medical science to scapulohumeral periarthritis relaxing muscles and tendons to promote blood circulation Therapeutic Principle, according to traditional Chinese medical science prescription and preparation principle, Chinese medicine composition is developed meticulously, the advantages such as one is pointed by force, good effect, the cycle is short, price is low, have no side effect are provided, patient can be made again to take like a shot, the pure Chinese medicinal preparation of the good cure scapulohumeral periarthritis of energy.Each component collaborative onset mutually in side, and medicine is prepared simple, rapid-action, short treating period, is had good therapeutical effect to scapulohumeral periarthritis.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese medicine composition being used for the treatment of scapulohumeral periarthritis, and its more existing treatment by Chinese herbs better can reduce the index of scapulohumeral periarthritis, improves the clinical sign of patient, prevents scapulohumeral periarthritis from worsening further.
For solving the problems of the technologies described above; the invention provides a kind of Chinese medicine composition being used for the treatment of scapulohumeral periarthritis, its raw material components comprises the Radix Angelicae Dahuricae, Flos Carthami, Myrrha, Radix Gentianae Macrophyllae, Calculus Bovis, Moschus, Radix Notoginseng, Herba Epimedii, Olibanum, Rhizoma Homalomenae, Radix Paeoniae Rubra, Galla Chinensis, Radix Stephaniae Tetrandrae, Pheretima and Rhizoma Paridis.
Wherein, in described Chinese medicine composition, the weight portion of each raw material components is respectively Radix Angelicae Dahuricae 8-12 weight portion, Flos Carthami 6-10 weight portion; Myrrha 4-10 weight portion, Radix Gentianae Macrophyllae 5-10 weight portion, Calculus Bovis 4-9 weight portion; Moschus 8-16 weight portion, Radix Notoginseng 8-17 weight portion, Herba Epimedii 5-11 weight portion; Olibanum 4-10 weight portion, Rhizoma Homalomenae 7-14 weight portion, Radix Paeoniae Rubra 10-18 weight portion; Galla Chinensis 8-12 weight portion; Radix Stephaniae Tetrandrae 12-18 weight portion, Pheretima 5-10 weight portion, Rhizoma Paridis 6-12 weight portion.
Preferably, in described Chinese medicine composition, the weight portion of each raw material components is respectively Radix Angelicae Dahuricae 10-12 weight portion, Flos Carthami 8-10 weight portion; Myrrha 7-10 weight portion, Radix Gentianae Macrophyllae 8-10 weight portion, Calculus Bovis 7-9 weight portion; Moschus 11-16 weight portion, Radix Notoginseng 14-17 weight portion, Herba Epimedii 8-11 weight portion; Olibanum 7-10 weight portion, Rhizoma Homalomenae 11-14 weight portion, Radix Paeoniae Rubra 14-18 weight portion; Galla Chinensis 10-12 weight portion; Radix Stephaniae Tetrandrae 15-18 weight portion, Pheretima 7-10 weight portion, Rhizoma Paridis 9-12 weight portion.
Further preferably, in described Chinese medicine composition, the weight portion of each raw material components is respectively the Radix Angelicae Dahuricae 10 weight portion, Flos Carthami 8 weight portion; Myrrha 7 weight portion, Radix Gentianae Macrophyllae 8 weight portion, Calculus Bovis 7 weight portion; Moschus 11 weight portion, Radix Notoginseng 14 weight portion, Herba Epimedii 8 weight portion; Olibanum 7 weight portion, Rhizoma Homalomenae 11 weight portion, Radix Paeoniae Rubra 14 weight portion; Galla Chinensis 10 weight portion; Radix Stephaniae Tetrandrae 15 weight portion, Pheretima 7 weight portion, Rhizoma Paridis 9 weight portion.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, its preparation process is:
Each component in described raw material components is mixed in proportion, pulverize, with 4-8 times amount water soaking 12-24 hour, extract volatile oil with steam distillation, medicinal residues after distillation and medicinal liquid are separately deposited, and at medicinal liquid reclaim under reduced pressure is concentrated into 75-85 DEG C, relative density is that 1.09-1.15 obtains A; Above-mentioned volatile oil adds 65% ethanol order in 1: 1 ratio and dissolves, adopt colloid milling, with volatile oil and beta-schardinger dextrin-ratio for 1: 5-8, beta-schardinger dextrin-and water ratio are 1: 2-4, suitable grinding rate grinding is taked to carry out enclose in 15-30 minute, obtain pastel, 50-60 DEG C is carried out dry, pulverize obtained clathrate B; Above-mentioned medicinal residues continuation 70-85% alcohol reflux 1-3 time, each 6-9 times amount ethanol, each 1-3 hour, merge extractive liquid, filters, decompression recycling ethanol to be concentrated into relative density at 75-85 DEG C be the C of 1.21-1.37; A and C is merged, dry, pulverize into fine powder in lower 80 DEG C of vacuum, add appropriate amount of auxiliary materials and make granule, mix with volatile oil beta cyclodextrin inclusion complex B, encapsulated and get final product.
The present invention also provides above-mentioned raw materials component for the preparation of the application in the Chinese medicine composition of cure scapulohumeral periarthritis.
Beneficial effect of the present invention:
The invention provides a kind of Chinese medicine composition being used for the treatment of scapulohumeral periarthritis, its more existing treatment by Chinese herbs better can reduce the index of scapulohumeral periarthritis, improve the clinical sign of patient, prevent scapulohumeral periarthritis from worsening further, have no side effect simultaneously, have safety and the comfort of height.
Detailed description of the invention
The weight portion that the present invention mentions is a proportionate relationship between each component.
The invention provides a kind of Chinese medicine composition being used for the treatment of scapulohumeral periarthritis, its raw material components comprises the Radix Angelicae Dahuricae, Flos Carthami, Myrrha, Radix Gentianae Macrophyllae, Calculus Bovis, Moschus, Radix Notoginseng, Herba Epimedii, Olibanum, Rhizoma Homalomenae, Radix Paeoniae Rubra, Galla Chinensis, Radix Stephaniae Tetrandrae, Pheretima and Rhizoma Paridis.
Further preferably, described Chinese medicine composition is only made up of above-mentioned raw materials component.
Chinese medicine composition compatibility of the present invention is reasonable, and action effect is remarkable, wherein:
The Radix Angelicae Dahuricae: pungent, temperature; Induce sweat cold expelling, wind-expelling pain-stopping, a surname's clearing the nasal passage, dampness leukorrhagia stopping, detumescence and apocenosis.For headache due to common cold, eyebrow shuttle osteodynia, nasal obstruction watery nasal discharge, allergic rhinitis, nasal sinusitis, toothache, leukorrhagia, skin infection swells and ache.
Flos Carthami: pungent, temperature; Promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain; For amenorrhea, dysmenorrhea, lochia, note of the ancient Chinese abdominal mass mass in the abdomen, obstruction of qi in the chest and cardialgia, the stagnant stomachache of the stasis of blood, costa sternales twinge, injury from falling down, skin infection swells and ache.
Myrrha: pungent, bitter is flat; Dissipating blood stasis analgesic therapy, detumescence and promoting granulation; For obstruction of qi in the chest and cardialgia, gastralgia, dysmenorrhea amenorrhea, lump in the abdomen is suffered from abdominal pain, rheumatic arthralgia, traumatic injury, carbuncle skin infection.
Radix Gentianae Macrophyllae: pungent, bitter is flat; Wind-damp dispelling, clearing away damp-heat, stopping numbness pain, reducing the asthenic fever; For rheumatic arthralgia, apoplexy and hemiplegia, the contracture of muscle arteries and veins, joint is ached, jaundice due to damp-heat, osteopyrexia and fever, and infantile malnutrition generates heat.
Calculus Bovis: sweet is cool; Clear away heart-fire, eliminating phlegm, cool liver, endogenous wind stopping, removing toxic substances; For calentura coma, middle wind-phlegm fan, infantile convulsion is twitched, and epilepsy is gone mad, laryngopharynx swelling and pain, aphtha of the mouth and tongue, carbuncle furuncle.
Moschus: pungent, temperature; To have one's ideas straightened out refreshment, promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain; For calentura coma, apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, attacked by pestiferous factors is gone into a coma, amenorrhea ， mass in the abdomen, difficult labour stillborn fetus, obstruction of qi in the chest and cardialgia, and trusted subordinate's sudden pain, falls and flutter the pain of injury, and arthralgia pain is numb, carbuncle scrofula, laryngopharynx swelling and pain.
Radix Notoginseng: sweet, micro-hardship, temperature; Dissipating blood stasis stops blooding, subduing swelling and relieving pain; For hemoptysis, haematemesis, metrorrhagia, traumatic hemorrhage, breast ventral spine pain, tumbling and swelling.
Herba Epimedii: acrid, sweet, warm; Kidney-replenishing, bone and muscle strengthening, wind-damp dispelling; For kidney yang deficiency, impotence and seminal emission, muscles and bones is withered soft, rheumatic arthralgia, numbness contracture.
Olibanum: pungent, bitter, temperature; To invigorate blood circulation analgesic therapy, detumescence and promoting granulation; For obstruction of qi in the chest and cardialgia, gastralgia, dysmenorrhea amenorrhea, postpartum stagnation ， mass in the abdomen is suffered from abdominal pain, rheumatic arthralgia, the contracture of muscle arteries and veins, traumatic injury, carbuncle skin infection.
Rhizoma Homalomenae: bitter, pungent, temperature; Wind-damp dispelling, strengthening bone and muscle; For anemofrigid-damp arthralgia, chills and pain of the waist and kness, contracture is numb, and muscles and bones flaccidity is soft.
Radix Paeoniae Rubra: bitter, is slightly cold; Clearing away heat and cooling blood, eliminating stasis to stop pain; Enter nutrient blood for heat, noxious dampness sends out speckle, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, and lump in the abdomen is suffered from abdominal pain, carbuncle skin infection.
Galla Chinensis: sour, puckery, cold; To astringe the lung pathogenic fire reducing, relieving diarrhea with astringents, arresting sweating, hemostasis, removing dampness sore; For chronic cough of deficiency lung, lung-heat phlegmatic cough, chronic diarrhea chronic dysentery, spontaneous sweating, quenches one's thirst, hemorrhoidal bleeding of having blood in stool, traumatic hemorrhage, carbuncle sore tumefacting virus, Skin wet and rotten.
Radix Stephaniae Tetrandrae: bitter, cold; Wind-expelling pain-stopping, inducing diuresis to remove edema; For rheumatic arthralgia, edema beriberi, dysuria, eczema sore.
Pheretima: salty, cold; Heat clearing away is calmed the frightened, and dredging collateral, relievings asthma, diuresis; For unconsciousness due to high fever, infantile convulsion is twitched, arthralgia, numb limbs and tense tendons, hemiplegia, dyspnea and cough due to lung-heat, edema oliguria.
Rhizoma Paridis: bitter, is slightly cold; Heat-clearing and toxic substances removing, reducing swelling and alleviating pain. cool liver arresting convulsion; For furuncle carbuncle, laryngopharynx swelling and pain, snake bite and insect sting, falls and flutters the pain of injury, convulsion with spasms.
In described Chinese medicine composition, the weight portion of each raw material components is respectively Radix Angelicae Dahuricae 8-12 weight portion, Flos Carthami 6-10 weight portion, Myrrha 4-10 weight portion; Radix Gentianae Macrophyllae 5-10 weight portion, Calculus Bovis 4-9 weight portion, Moschus 8-16 weight portion; Radix Notoginseng 8-17 weight portion, Herba Epimedii 5-11 weight portion, Olibanum 4-10 weight portion; Rhizoma Homalomenae 7-14 weight portion; Radix Paeoniae Rubra 10-18 weight portion, Galla Chinensis 8-12 weight portion, Radix Stephaniae Tetrandrae 12-18 weight portion; Pheretima 5-10 weight portion, Rhizoma Paridis 6-12 weight portion.
Preferably, in described Chinese medicine composition, the weight portion of each raw material components is respectively Radix Angelicae Dahuricae 10-12 weight portion, Flos Carthami 8-10 weight portion; Myrrha 7-10 weight portion, Radix Gentianae Macrophyllae 8-10 weight portion, Calculus Bovis 7-9 weight portion; Moschus 11-16 weight portion, Radix Notoginseng 14-17 weight portion, Herba Epimedii 8-11 weight portion; Olibanum 7-10 weight portion, Rhizoma Homalomenae 11-14 weight portion, Radix Paeoniae Rubra 14-18 weight portion; Galla Chinensis 10-12 weight portion; Radix Stephaniae Tetrandrae 15-18 weight portion, Pheretima 7-10 weight portion, Rhizoma Paridis 9-12 weight portion.
Further preferably, in described Chinese medicine composition, the weight portion of each raw material components is respectively the Radix Angelicae Dahuricae 10 weight portion, Flos Carthami 8 weight portion; Myrrha 7 weight portion, Radix Gentianae Macrophyllae 8 weight portion, Calculus Bovis 7 weight portion; Moschus 11 weight portion, Radix Notoginseng 14 weight portion, Herba Epimedii 8 weight portion; Olibanum 7 weight portion, Rhizoma Homalomenae 11 weight portion, Radix Paeoniae Rubra 14 weight portion; Galla Chinensis 10 weight portion; Radix Stephaniae Tetrandrae 15 weight portion, Pheretima 7 weight portion, Rhizoma Paridis 9 weight portion.
The Chinese medicine composition of cure scapulohumeral periarthritis provided by the invention can be prepared into various peroral dosage form according to regular dosage form preparation method.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, comprising:
Each component in described raw material components is mixed in proportion, pulverize, with 4-8 times amount water soaking 12-24 hour, extract volatile oil with steam distillation, medicinal residues after distillation and medicinal liquid are separately deposited, and at medicinal liquid reclaim under reduced pressure is concentrated into 75-85 DEG C, relative density is that 1.09-1.15 obtains A; Above-mentioned volatile oil adds 65% ethanol order in 1: 1 ratio and dissolves, adopt colloid milling, with volatile oil and beta-schardinger dextrin-ratio for 1: 5-8, beta-schardinger dextrin-and water ratio are 1: 2-4, suitable grinding rate grinding is taked to carry out enclose in 15-30 minute, obtain pastel, 50-60 DEG C is carried out dry, pulverize obtained clathrate B; Above-mentioned medicinal residues continuation 70-85% alcohol reflux 1-3 time, each 6-9 times amount ethanol, each 1-3 hour, merge extractive liquid, filters, decompression recycling ethanol to be concentrated into relative density at 75-85 DEG C be the C of 1.21-1.37; A and C is merged, dry, pulverize into fine powder in lower 80 DEG C of vacuum, add appropriate amount of auxiliary materials and make granule, mix with volatile oil beta cyclodextrin inclusion complex B, encapsulated and get final product.
The present invention also provides above-mentioned raw materials component for the preparation of the application in the Chinese medicine composition of cure scapulohumeral periarthritis.
Embodiment
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1
Get the Radix Angelicae Dahuricae 8 weight portion, Flos Carthami 6 weight portion, Myrrha 4 weight portion, Radix Gentianae Macrophyllae 5 weight portion, Calculus Bovis 4 weight portion, Moschus 8 weight portion, Radix Notoginseng 8 weight portion, Herba Epimedii 5 weight portion, Olibanum 4 weight portion, Rhizoma Homalomenae 7 weight portion, Radix Paeoniae Rubra 10 weight portion, Galla Chinensis 8 weight portion, Radix Stephaniae Tetrandrae 12 weight portion, Pheretima 5 weight portion, Rhizoma Paridis 6 weight portion, be mixed in proportion, pulverize, with 4 times amount water soaking 12 hours, extract volatile oil with steam distillation, medicinal residues after distillation and medicinal liquid are separately deposited, at medicinal liquid reclaim under reduced pressure is concentrated into 75 DEG C relative density be 1.09 A; Above-mentioned volatile oil adds 65% ethanol order in 1: 1 ratio and dissolves, adopt colloid milling, with volatile oil and beta-schardinger dextrin-ratio for 1: 5, beta-schardinger dextrin-and water ratio are 1: 2, take suitable grinding rate to grind and carry out enclose in 15 minutes, obtain pastel, 50 DEG C are carried out dry, pulverize obtained clathrate B; Above-mentioned medicinal residues continue with 70% alcohol reflux 1 time, each 6 times amount ethanol, each 1 hour, merge extractive liquid, filtration, decompression recycling ethanol to be concentrated into relative density at 75 DEG C be the C of 1.21; A and C is merged, dry, pulverize into fine powder in lower 80 DEG C of vacuum, add appropriate amount of auxiliary materials and make granule, mix with volatile oil beta cyclodextrin inclusion complex B, encapsulated and get final product.
Usage and consumption: every day, (medicine) being taken before meal was with three times, each 3.
Taboo: (1) avoids eating anything raw or cold food; (2) diet raw meat thing; (3) internal and external haemorrhage disease, ulcerate disease tool avoid clothes first; (4) female menstrual period, the pregnancy period is not used.
Embodiment 2
Get the Radix Angelicae Dahuricae 12 weight portion, Flos Carthami 10 weight portion, Myrrha 10 weight portion, Radix Gentianae Macrophyllae 10 weight portion, Calculus Bovis 9 weight portion, Moschus 16 weight portion, Radix Notoginseng 17 weight portion, Herba Epimedii 11 weight portion, Olibanum 10 weight portion, Rhizoma Homalomenae 14 weight portion, Radix Paeoniae Rubra 18 weight portion, Galla Chinensis 12 weight portion, Radix Stephaniae Tetrandrae 18 weight portion, Pheretima 10 weight portion, Rhizoma Paridis 12 weight portion, be mixed in proportion, pulverize, with 8 times amount water soaking 24 hours, extract volatile oil with steam distillation, medicinal residues after distillation and medicinal liquid are separately deposited, at medicinal liquid reclaim under reduced pressure is concentrated into 85 DEG C relative density be 1.15 A; Above-mentioned volatile oil adds 65% ethanol order in 1: 1 ratio and dissolves, adopt colloid milling, with volatile oil and beta-schardinger dextrin-ratio for 1: 8, beta-schardinger dextrin-and water ratio are 1: 4, take suitable grinding rate to grind and carry out enclose in 30 minutes, obtain pastel, 60 DEG C are carried out dry, pulverize obtained clathrate B; Above-mentioned medicinal residues continue with 85% alcohol reflux 3 times, each 9 times amount ethanol, each 3 hours, merge extractive liquid, filtration, decompression recycling ethanol to be concentrated into relative density at 85 DEG C be the C of 1.37; A and C is merged, dry, pulverize into fine powder in lower 80 DEG C of vacuum, add appropriate amount of auxiliary materials and make granule, mix with volatile oil beta cyclodextrin inclusion complex B, encapsulated and get final product.
Usage and consumption, avoid same embodiment 1.
Embodiment 3
Get the Radix Angelicae Dahuricae 10 weight portion, Flos Carthami 8 weight portion, Myrrha 7 weight portion, Radix Gentianae Macrophyllae 8 weight portion, Calculus Bovis 7 weight portion, Moschus 11 weight portion, Radix Notoginseng 14 weight portion, Herba Epimedii 8 weight portion, Olibanum 7 weight portion, Rhizoma Homalomenae 11 weight portion, Radix Paeoniae Rubra 14 weight portion, Galla Chinensis 10 weight portion, Radix Stephaniae Tetrandrae 15 weight portion, Pheretima 7 weight portion, Rhizoma Paridis 9 weight portion, be mixed in proportion, pulverize, with 6 times amount water soaking 18 hours, extract volatile oil with steam distillation, medicinal residues after distillation and medicinal liquid are separately deposited, at medicinal liquid reclaim under reduced pressure is concentrated into 80 DEG C relative density be 1.12 A; Above-mentioned volatile oil adds 65% ethanol order in 1: 1 ratio and dissolves, adopt colloid milling, with volatile oil and beta-schardinger dextrin-ratio for 1: 7, beta-schardinger dextrin-and water ratio are 1: 3, take suitable grinding rate to grind and carry out enclose in 25 minutes, obtain pastel, 55 DEG C are carried out dry, pulverize obtained clathrate B; Above-mentioned medicinal residues continue with 75% alcohol reflux 2 times, each 8 times amount ethanol, each 2 hours, merge extractive liquid, filtration, decompression recycling ethanol to be concentrated into relative density at 80 DEG C be the C of 1.28; A and C is merged, dry, pulverize into fine powder in lower 80 DEG C of vacuum, add appropriate amount of auxiliary materials and make granule, mix with volatile oil beta cyclodextrin inclusion complex B, encapsulated and get final product.
Usage and consumption, avoid same embodiment 1.
Embodiment 4 toxicity test
Below test, if no special instructions, all use the Chinese medicine composition that the embodiment of the present invention 3 is obtained.
1, acute toxicity test:
Once give mouse stomach Chinese medicine composition 21.1g/kg of the present invention, be equivalent to crude drug amount 82g/kg, Continuous Observation 7 days, has no any toxic reaction and death.Mtd test shows, in 24 hours, give mouse stomach every minor tick 4 hour three times with above-mentioned dosage, total dosage is 246g crude drug/kg, is equivalent to 215 times of clinical people's oral dose.Illustrate that this product toxicity is very little, clinical plan consumption is safer.
2, long term toxicity test:
To continuous 6 weeks of SD rat respectively gavage give 5.1g/kg, 3.4g/kg, the Chinese medicine composition of the present invention of 1.7g/kg tri-dosage, laboratory animal terminates and convalescent period in administration, and hematological indices, blood parameters and matched group ratio are all without significant difference (p > 0.05).System becomes celestial and histopathologic examination has no drug-induced abnormal change and retardance toxic reaction.
Embodiment 5 clinical experiment
1, physical data: the patient of 200 routine scapulohumeral periarthritis is divided at random treatment group and matched group two groups, two groups of sexes, age and courses of disease, through statistics there was no significant difference (P > 0.05), have comparability.
2, diagnostic criteria:
(1) shoulder pain, gradually increases the weight of, and light night in daytime is heavy, and can to neck, ear, omoplate and forearm and hands radiation;
(2) shoulder joint is lifted, after the pain increased when stretching, shoulder limitation of activity, severe patient can not be worn the clothes, comb one's hair, the action such as wash one's face;
(3) shoulder swelling is not obvious, has popularity tenderness around shoulder joint, with the passing of time visible shoulder muscle atrophy.
3, usage and dosage:
Treatment group takes pharmaceutical composition of the present invention, and each serving with 3, every containing crude drug 0.4g, take 3 every day, serveing on 7 is a course for the treatment of, can drug withdrawal 1 day between the course for the treatment of and the course for the treatment of, if suffer from other new diseases also answer drug withdrawal such as diarrhoea waits.
Matched group takes Qubi Shujian Pills (concentrated pill) by doctor's advice: the pharmaceutical factory of traditional Chinese medicine of Shantou, Guangdong city produces.Clinical consumption per day is 15g/ days.。
4, the standard of curative effect evaluation:
Recovery from illness: shoulder joint function recovers normal, and pain disappears, around without tenderness and sensitive spot.
Effective: the energy-conservation abduction of shoulder joint, after stretch 70 °, pain substantially disappears or obviously alleviates, without obvious pressure pain point.
Effective: the energy-conservation abduction of shoulder joint, after stretch 50 °, shoulder can touch pressure pain point.
Invalid: before and after treatment, the state of an illness is unchanged.
5, observation of curative effect: through two course of therapy, two groups of therapeutic effect are in table 1.Can find out that treatment group effective percentage is apparently higher than matched group (P < 0.05) by table 1.Chinese medicine composition of the present invention can effective cure scapulohumeral periarthritis.
Therapeutic outcome is in table 1.Total effective rate=(recovery from illness number of cases+effective number of cases+effectively number of cases)/total number of cases.
Table 1: the comparison of two groups of patient clinical curative effects after treatment
| Group | Total number of cases | Recovery from illness number of cases | Effective number of cases | Effective number of cases | Invalid number of cases | Total effective rate (%) |
| Treatment group | 100 | 55 | 18 | 20 | 7 | 93 |
| Matched group | 100 | 24 | 17 | 19 | 40 | 60 |
Through treating and following up a case by regular visits to, result display treatment group total effective rate 93%, be significantly better than matched group, P<0.05, difference has statistical significance, and abundant proved invention Chinese medicine composition has significant clinical efficacy to scapulohumeral periarthritis.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (6)
1. be used for the treatment of a Chinese medicine composition for scapulohumeral periarthritis, it is characterized in that: raw material components comprises the Radix Angelicae Dahuricae, Flos Carthami, Myrrha, Radix Gentianae Macrophyllae, Calculus Bovis, Moschus, Radix Notoginseng, Herba Epimedii, Olibanum, Rhizoma Homalomenae, Radix Paeoniae Rubra, Galla Chinensis, Radix Stephaniae Tetrandrae, Pheretima and Rhizoma Paridis.
2. Chinese medicine composition as claimed in claim 1, is characterized in that: the weight portion of each raw material components is respectively Radix Angelicae Dahuricae 8-12 weight portion, Flos Carthami 6-10 weight portion; Myrrha 4-10 weight portion, Radix Gentianae Macrophyllae 5-10 weight portion, Calculus Bovis 4-9 weight portion; Moschus 8-16 weight portion, Radix Notoginseng 8-17 weight portion, Herba Epimedii 5-11 weight portion; Olibanum 4-10 weight portion, Rhizoma Homalomenae 7-14 weight portion, Radix Paeoniae Rubra 10-18 weight portion; Galla Chinensis 8-12 weight portion; Radix Stephaniae Tetrandrae 12-18 weight portion, Pheretima 5-10 weight portion, Rhizoma Paridis 6-12 weight portion.
3. Chinese medicine composition as claimed in claim 1 or 2; it is characterized in that: the weight portion of each raw material components is respectively Radix Angelicae Dahuricae 10-12 weight portion; Flos Carthami 8-10 weight portion; Myrrha 7-10 weight portion; Radix Gentianae Macrophyllae 8-10 weight portion; Calculus Bovis 7-9 weight portion, Moschus 11-16 weight portion, Radix Notoginseng 14-17 weight portion; Herba Epimedii 8-11 weight portion; Olibanum 7-10 weight portion, Rhizoma Homalomenae 11-14 weight portion, Radix Paeoniae Rubra 14-18 weight portion; Galla Chinensis 10-12 weight portion; Radix Stephaniae Tetrandrae 15-18 weight portion, Pheretima 7-10 weight portion, Rhizoma Paridis 9-12 weight portion.
4. the Chinese medicine composition as described in claims 1 to 3, is characterized in that: the weight portion that the weight portion of each raw material components is respectively each raw material components is respectively the Radix Angelicae Dahuricae 10 weight portion, Flos Carthami 8 weight portion; Myrrha 7 weight portion, Radix Gentianae Macrophyllae 8 weight portion, Calculus Bovis 7 weight portion; Moschus 11 weight portion, Radix Notoginseng 14 weight portion, Herba Epimedii 8 weight portion; Olibanum 7 weight portion, Rhizoma Homalomenae 11 weight portion, Radix Paeoniae Rubra 14 weight portion; Galla Chinensis 10 weight portion; Radix Stephaniae Tetrandrae 15 weight portion, Pheretima 7 weight portion, Rhizoma Paridis 9 weight portion.
5. the preparation method of Chinese medicine composition described in Claims 1-4, is characterized in that, preparation process is:
Each component in described raw material components is mixed in proportion, pulverize, with 4-8 times amount water soaking 12-24 hour, extract volatile oil with steam distillation, medicinal residues after distillation and medicinal liquid are separately deposited, and at medicinal liquid reclaim under reduced pressure is concentrated into 75-85 DEG C, relative density is that 1.09-1.15 obtains A; Above-mentioned volatile oil adds 65% ethanol order in 1: 1 ratio and dissolves, adopt colloid milling, with volatile oil and beta-schardinger dextrin-ratio for 1: 5-8, beta-schardinger dextrin-and water ratio are 1: 2-4, suitable grinding rate grinding is taked to carry out enclose in 15-30 minute, obtain pastel, 50-60 DEG C is carried out dry, pulverize obtained clathrate B; Above-mentioned medicinal residues continuation 70-85% alcohol reflux 1-3 time, each 6-9 times amount ethanol, each 1-3 hour, merge extractive liquid, filters, decompression recycling ethanol to be concentrated into relative density at 75-85 DEG C be the C of 1.21-1.37; A and C is merged, dry, pulverize into fine powder in lower 80 DEG C of vacuum, add appropriate amount of auxiliary materials and make granule, mix with volatile oil beta cyclodextrin inclusion complex B, encapsulated and get final product.
6. the raw material components any one of claim 1-4 is for the preparation of the application in the Chinese medicine composition of cure scapulohumeral periarthritis.
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| CN103784769A (en) * | 2014-03-07 | 2014-05-14 | 王奎林 | Chinese herbal preparation for treating orthopedic diseases |
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| CN1616068A (en) * | 2004-10-21 | 2005-05-18 | 郑红科 | Chinese medicine decoction for treating neck-shoulder and waist-leg pain |
| CN1824009A (en) * | 2005-02-22 | 2006-08-30 | 林立树 | Multipurpose medicinal composition capable of oral administration and external use |
| CN100998838A (en) * | 2006-12-29 | 2007-07-18 | 张秋霞 | Chinese medicine for relaxing muscles and tendons to promote blood circulation preparation method thereof |
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Application publication date: 20160106 |