CN105213715A - A kind of Chinese medicine preparation of curing hyperosteogeny for external application - Google Patents
A kind of Chinese medicine preparation of curing hyperosteogeny for external application Download PDFInfo
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Abstract
The invention belongs to the field of Chinese medicines, relate to a kind of Chinese medicine preparation of curing hyperosteogeny for external application, described Chinese medicine preparation is prepared from primarily of the raw material of following parts by weight: Folium Artemisiae Argyi 18-25 part, Rhizoma Et Radix Notopterygii 20-28 part, Caulis Sinomenii 16-22 part, Radix Astragali 17-23 part, umbrella plant 14-22 part, Herba Schisandrae intermediae 15-20 part, Folium Ginkgo 14-20 part, Radix Puerariae 12-16 part, Rhizoma Dioscoreae 8-16 part, Herba Epimedii 12-18 part, Radix Rhodiolae 9-15 part, Radix Aucklandiae 9-15 part and Radix Glycyrrhizae 10-15 part.Chinese medicine preparation of the present invention has blood circulation promoting and blood stasis dispelling, soothing the channels and quicking the network vessels, functions dispelling wind and clearing away cold, removing dampness, effect of the kidney invigorating bone and muscle strengthening, and Chinese medicine preparation penetration of the present invention is strong, and instant effect, with strong points, do not recur, medication is simple and convenient, without any side effects.
Description
Technical field
The invention belongs to tcm field, be specifically related to a kind of Chinese medicine preparation of curing hyperosteogeny for external application.
Background technology
Hyperosteogeny is also called hyperplastic osteoarthritis, osteoarthritis, degenerative joint disease, senile arthritis, hypertrophiarthritis.Usually occur in the positions such as cervical vertebra, lumbar vertebra, knee, heel, cardinal symptom is arthralgia, often betides daystart, and after movable, pain alleviates on the contrary, but as hyperactivity, pain can increase the weight of again.Check the swelling of affected joints visible joint, tenderness, have friction sense or " click clatter " sound time movable, the person of being in a bad way can have the symptom of amyotrophy and joint deformity.The traditional Chinese medical science thinks that primary disease is relevant with wound, strain, obstruction of collaterals by blood stasis, the damp that is affected by the cold, phlegm resistance, caused by liver and kidney deficiency etc.Motherland's medical science think hyperosteogeny often because experiencing wind, cold, wet, hot wound, strain cause neck, lumbar vertebra, knee hyperplasia change and occur, and then pressuring neural root, impatency meridians, cause that QI-blood circulation is smooth, qi depression to blood stasis.Doctor trained in Western medicine then thinks that the cause of disease mainly causes bone network Leukopenia to cause because the calcareous forfeiture of bone and calcium ion metabolic function go down.
The reason affecting hyperosteogeny generation has a lot, mainly contains the congenital malformation, metabolic factor, Nervous and Mental Factors etc. of age factor, chronic strain, wound, bottleneck throat inflammation, developmental spinal stenosis, cervical vertebra.Treatment bone matrix hyperplasia there is no effective medicine both at home and abroad at present, and the traditional Chinese medical science is mainly with invigorating the liver and kidney, and wind-damp dispelling, reducing swelling and alleviating pain, relaxing muscles and tendons to promote blood circulation is main, is aided with existing Chinese herbal medicine and treats, and the Therapeutic Principle of doctor trained in Western medicine is antiinflammatory, analgesia.Conventional method has galvanoiontophoresis method, ultraviolet therapy, massage and traction, acupuncture, forces on, operative treatment etc.Galvanoiontophoresis method has given full play to the effect of medicine, but is liquid because importing medicine, volatile, and drug effect is not lasting, limits the therapeutic effect of the method.Massage and the effect of the complete outer power of drawing method, only integrally regulating in human body locally treating but to ignore, therefore, can only play temporary transient analgesic effect, and can not reach the object for the treatment of.Acupuncture method can restore menstrual flow and invigorate blood circulation and have analgesic effect, can eliminate edema and the inflammation of local, but can only help out concerning acupuncture hyperosteogeny.Western medical treatment commonly uses the antibiotic medicine such as dexamethasone, ibuprofen or analgesic treatment hyperosteogeny, also the employing androgen had, vitamin, sour calcium, long-acting calcitonin are treated, arthroncus has hydrops, and person takes local to extract hydrops or partial closure etc., curative effect is relief of symptoms, therapeutic process has certain damage to liver, kidney, gastrointestinal, just take stopgap measures and do not effect a permanent cure, the state of an illness easily recurs.Therefore select Therapeutic Method that is timely, regular, effective, that do not have side effect to be crucial, the advantage that external traditional Chinese medicinal application treats hyperosteogeny maximum is to effect a radical cure from pathology.
Nowadays in treatment hyperosteogeny, be difficult to control by the dose of internal organs decomposition arrival disease sites because oral medicine also exists medicine, the property of medicine is strong injures internal organs, the property of medicine is low does not reach the drawback of therapeutic effect, and sight has turned to by people to be needed on the liniment of scalable property of medicine intensity according to the individual variation of people.Record according to traditional Chinese medical science canon Huangdi's Internal Classics, in tradition doctor bone strange method, the most effective means are that room temperature in water-soluble transdermal art dresses therapy, be commonly called as " poultice ", refer to and reconcile into pasty state with watery wine etc. after being pulverized by high-quality Chinese medicine formula, apply a kind of transdermal methods carrying out in local treating.Feature does not heat, and dose is large, dissociates.What Gu had " one sticks with paste gas hundred cream " says, act on affected site, its usefulness surmounts common unguentum tens, and even hundreds of times, has penetration strong, absorbs the features such as fast.
Chinese patent application CN201210366681 discloses a kind of Chinese pill for curing hyperosteogeny, certain weight ratio is pressed formulated by Radix Rehmanniae Preparata, Herba Cistanches, Radix Puerariae, Rhizoma Drynariae, Herba Epimedii, Herba Pyrolae, Caulis Spatholobi and Semen Raphani, this Drug therapy hyperosteogeny instant effect, effective percentage is high, but cure the symptoms, not the disease, there is the deficiency of easily recurrence.
Summary of the invention
For solving the deficiencies in the prior art, the object of this invention is to provide a kind of Chinese medicine preparation of curing hyperosteogeny for external application.
For realizing object of the present invention, the present inventor is according to the research of theory of Chinese medical science and clinical test repeatedly and checking, provide a kind of Chinese medicine preparation of curing hyperosteogeny for external application, it is characterized in that, described Chinese medicine preparation is mainly prepared from by the raw material of following parts by weight:
Folium Artemisiae Argyi 18-25 part, Rhizoma Et Radix Notopterygii 20-28 part, Caulis Sinomenii 16-22 part, Radix Astragali 17-23 part, umbrella plant 14-22 part, Herba Schisandrae intermediae 15-20 part, Folium Ginkgo 14-20 part, Radix Puerariae 12-16 part, Rhizoma Dioscoreae 8-16 part, Herba Epimedii 12-18 part, Radix Rhodiolae 9-15 part, Radix Aucklandiae 9-15 part and Radix Glycyrrhizae 10-15 part.
Preferably, the Chinese medicine preparation of curing hyperosteogeny for external application of the present invention is mainly prepared by the medical material of following parts by weight:
Folium Artemisiae Argyi 18 parts, Rhizoma Et Radix Notopterygii 20 parts, Caulis Sinomenii 16 parts, the Radix Astragali 17 parts, umbrella plant 14 parts, Herba Schisandrae intermediae 15 parts, Folium Ginkgo 14 parts, Radix Puerariae 12 parts, Rhizoma Dioscoreae 8 parts, Herba Epimedii 12 parts, Radix Rhodiolae 9 parts, the Radix Aucklandiae 9 parts and 10 parts, Radix Glycyrrhizae.
Further preferably, the Chinese medicine preparation of curing hyperosteogeny for external application of the present invention is mainly prepared by the medical material of following parts by weight:
Folium Artemisiae Argyi 25 parts, Rhizoma Et Radix Notopterygii 28 parts, Caulis Sinomenii 22 parts, the Radix Astragali 23 parts, umbrella plant 22 parts, Herba Schisandrae intermediae 20 parts, Folium Ginkgo 20 parts, Radix Puerariae 16 parts, Rhizoma Dioscoreae 16 parts, Herba Epimedii 18 parts, Radix Rhodiolae 15 parts, the Radix Aucklandiae 15 parts and 15 parts, Radix Glycyrrhizae.
Still more preferably, the Chinese medicine preparation of curing hyperosteogeny for external application of the present invention is mainly prepared by the medical material of following parts by weight:
Folium Artemisiae Argyi 22 parts, Rhizoma Et Radix Notopterygii 26 parts, Caulis Sinomenii 20 parts, the Radix Astragali 20 parts, umbrella plant 18 parts, Herba Schisandrae intermediae 18 parts, Folium Ginkgo 18 parts, Radix Puerariae 14 parts, Rhizoma Dioscoreae 12 parts, Herba Epimedii 15 parts, Radix Rhodiolae 13 parts, the Radix Aucklandiae 12 parts and 15 parts, Radix Glycyrrhizae.
Source, the nature and flavor of Chinese medicine preparation of the present invention Chinese crude drug used, return through and effect:
Folium Artemisiae Argyi: this product is the dried leaves of feverfew Chinese mugwort.Acrid in the mouth, hardship; Warm in nature.Return liver,spleen,kidney warp.Dispersing cold for relieving pain, warming the meridian for stopping bleeding, for spitting blood, epistaxis; External treatment skin pruritus.
Rhizoma Et Radix Notopterygii: this product is dry rhizome and the root of samphire Rhizoma Et Radix Notopterygii.Acrid in the mouth, hardship; Warm in nature.Return bladder, kidney channel.Cold expelling, dispels the wind, dehumidifying, pain relieving, for anemofrigid cold headache, and rheumatic arthralgia, aching pain in should and back.
Caulis Sinomenii: this product is stem and leaf or the root of Sabiaceae plant Caulis Sinomenii.Bitter in the mouth, pungent; Warm in nature.Return Liver Channel.Expelling wind and removing dampness; Promoting blood circulation and detoxication.Main air pain of dampness syndrome; The arthroncus of knee; Edema; Foot gas; Treating swelling and pain by traumatic injury; Fracture; Deep abscess; Osteomyelitis; Suppurative arthritis; Spondylitis; Sore swollen toxin; Skin pruritus.
The Radix Astragali: this product is the dry root of the plant Radix Astragali.Sweet, tepor.Return lung, spleen, liver, kidney channel.Have tonifying Qi and lifting yang, function that benefit defends consolidating superficial resistance.
Umbrella plant: this product is the stem and leaf of sedge cyperus alternifolius.Sweet in the mouth, micro-hardship; Cool in nature.Return Liver Channel.Promoting flow of QI and blood; Removing toxic substances.Main blood stasis is had a pain; Snake bite and insect sting
Herba Schisandrae intermediae: this product is rattan and the root that Schisandraceae Plant closes stamen Fructus Schisandrae Chinensis.Bitter in the mouth, pungent; Property is put down.Return Liver Channel.Heat-clearing and toxic substances removing; Promoting blood circulation and detumescence.Main flow sense; Carbuncle sore tumefacting virus; Venom; Rheumatic numbness; Traumatic injury.
Folium Ginkgo: this product is the dried leaves of Ginkgoaceae plant Ginkgo biloba; Sweet, bitter, puckery, flat; GUIXIN, lung meridian; Blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, astringes the lung and relievings asthma, and changes turbid blood fat reducing.
Radix Puerariae: this product is the dry root of legume pueraria lobata or Radix Puerariae rattan.Sweet in the mouth, pungent; Cool in nature.Return spleen, stomach warp.Expelling pathogenic factors from muscles for reducing heat, promotes the production of body fluid, rash, yang invigorating antidiarrheal, for fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quenches one's thirst, measles without adequate eruption, and hematodiarrhoea, has loose bowels; Hypertension neck pain.
Rhizoma Dioscoreae: this product is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae.Sweet in the mouth; Property is put down.Return spleen, lung, kidney channel.Spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst.
Herba Epimedii: this product is the dry aerial parts of Berberidaceae plant Herba Epimedii, Epimedium sagittatum, E. Pubescens, Epimedium wushanense or Herba Epimedii.Acrid in the mouth, sweet; Warm in nature.Return liver, kidney channel.Kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension.
Radix Rhodiolae: this product is the dry Herb of plant Radix Rhodiolae; Cold, sweet, puckery; Lung meridian; Have QI invigorating lung heat clearing, Fructus Alpiniae Oxyphyllae nourished heart, effect of hemostasis with astringents, dissipating blood stasis for subsidence of swelling.Cure mainly deficiency of vital energy and physically weak, after being ill fear of cold, shortness of breath and fatigue, cough due to lung-heat, spitting of blood, leucorrhea diarrhoea, traumatic injury etc.
The Radix Aucklandiae: this product is the dry root of the feverfew Radix Aucklandiae.Acrid in the mouth, hardship; Warm in nature.Return spleen, stomach, large intestine, three burnt, gallbladder meridians.Promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.For breast gastral cavity distending pain, heavy after dysentery, food stagnation does not disappear, anorexia.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth; Property is put down.Gui Jing, GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
The prescription analysis of Chinese medicine of the present invention:
According to the compatibility theory of the traditional Chinese medical science to the dialectical and Chinese crude drug for the treatment of hyperosteogeny, in conjunction with the body constitution of modern and the feature of modern pharmaceutical technology, the collocation ingredients of reasonable science, forms Chinese prescription of the present invention.Prescription of the present invention is with Folium Artemisiae Argyi, Rhizoma Et Radix Notopterygii, Caulis Sinomenii for monarch drug, promoting blood circulation and stopping pain, expelling wind and removing dampness, dispersing cold for relieving pain; With the Radix Astragali, umbrella plant, Herba Schisandrae intermediae for ministerial drug, promoting blood circulation and detumescence, promoting flow of QI and blood; With Folium Ginkgo, Radix Puerariae, Rhizoma Dioscoreae for adjuvant drug, activating YANG and eliminating stagnation, heat-clearing and toxic substances removing; With Herba Epimedii, Radix Rhodiolae, the Radix Aucklandiae and Radix Glycyrrhizae for making medicine, promoting blood circulation to restore menstrual flow, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription; The all medicines of monarch coordinate, and collaborative promotion, complements each other, finally reach blood circulation promoting and blood stasis dispelling, soothing the channels and quicking the network vessels, functions dispelling wind and clearing away cold, removing dampness, effect of the kidney invigorating bone and muscle strengthening, be applicable to hyperosteogeny patient.
The preparation method of Chinese medicine preparation of the present invention is as follows:
S1: get Folium Artemisiae Argyi, Rhizoma Et Radix Notopterygii, Caulis Sinomenii, the Radix Astragali, umbrella plant, Herba Schisandrae intermediae, Folium Ginkgo, Radix Puerariae, Rhizoma Dioscoreae, Herba Epimedii, Radix Rhodiolae, the Radix Aucklandiae and Radix Glycyrrhizae, wash away impurity, pulverize respectively after drying, crosses 60-80 mesh sieve, for subsequent use;
S2: get Folium Ginkgo coarse powder, be placed in supercritical carbon dioxide extraction apparatus, adding coarse powder total amount 30-45% volume fraction is the ethanol of 60-85%, regulation and control carbon dioxide flow is 15-20L/h, extracting pressure is 15-20MPa, and extraction temperature is 40-60 DEG C, and extraction time is 1.5-2h, decompression separation obtains Folium Ginkgo extract, retains Folium Ginkgo residue;
S3: get Folium Artemisiae Argyi, Rhizoma Et Radix Notopterygii, Caulis Sinomenii, the Radix Astragali, umbrella plant, Herba Schisandrae intermediae, Radix Puerariae, Rhizoma Dioscoreae, Herba Epimedii, Radix Rhodiolae, the Radix Aucklandiae and Radix Glycyrrhizae coarse powder, add the water of coarse powder total amount 10-12 times amount and the cellulase of coarse powder total amount 1%-2.5%, adjustment PH is 4.50-5.0, lixiviate 1-2 hour at 50-65 DEG C, then at 80-95 DEG C of reflux, extract, 1-2 hour, filter, filtrate and described Folium Ginkgo extract merge, and being evaporated to relative density at 60 DEG C after mix homogeneously is the extractum of 1.10-1.25;
S4: mixed with the extractum of S3 gained by described Folium Ginkgo residue, drying under reduced pressure, pulverizes, and crosses 80-100 mesh sieve, to obtain final product.
Chinese medicine preparation of the present invention, come from the achievement in research of China's Chinese medical theory and modern pharmacology, through pharmacodynamic experiment research, clinical practice treatment use, prove its determined curative effect in treatment hyperosteogeny, have no adverse reaction, there are blood circulation promoting and blood stasis dispelling, soothing the channels and quicking the network vessels, functions dispelling wind and clearing away cold, removing dampness, effect of the kidney invigorating bone and muscle strengthening.Chinese medicine preparation instant effect of the present invention, with strong points, skin absorbs fast, and bioavailability is high, and it is convenient to be suitable for, and has no side effect.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, be all included within the scope of the present invention.
EXAMPLE l
The embodiment of the present invention 1 Chinese medicine preparation is prepared from by the raw material of following parts by weight:
18 parts, leaf, Rhizoma Et Radix Notopterygii 20 parts, Caulis Sinomenii 16 parts, the Radix Astragali 17 parts, umbrella plant 14 parts, Herba Schisandrae intermediae 15 parts, Folium Ginkgo 14 parts, Radix Puerariae 12 parts, Rhizoma Dioscoreae 8 parts, Herba Epimedii 12 parts, Radix Rhodiolae 9 parts, the Radix Aucklandiae 9 parts and 10 parts, Radix Glycyrrhizae.
Preparation method:
S1: get Folium Artemisiae Argyi, Rhizoma Et Radix Notopterygii, Caulis Sinomenii, the Radix Astragali, umbrella plant, Herba Schisandrae intermediae, Folium Ginkgo, Radix Puerariae, Rhizoma Dioscoreae, Herba Epimedii, Radix Rhodiolae, the Radix Aucklandiae and Radix Glycyrrhizae, wash away impurity, pulverize respectively after drying, crosses 80 mesh sieves, for subsequent use;
S2: get Folium Ginkgo coarse powder, be placed in supercritical carbon dioxide extraction apparatus, adding coarse powder total amount 30% volume fraction is the ethanol of 60%, regulation and control carbon dioxide flow is 15L/h, extracting pressure is 15MPa, and extraction temperature is 40 DEG C, and extraction time is 2h, decompression separation obtains Folium Ginkgo extract, retains Folium Ginkgo residue;
S3: get Folium Artemisiae Argyi, Rhizoma Et Radix Notopterygii, Caulis Sinomenii, the Radix Astragali, umbrella plant, Herba Schisandrae intermediae, Radix Puerariae, Rhizoma Dioscoreae, Herba Epimedii, Radix Rhodiolae, the Radix Aucklandiae and Radix Glycyrrhizae coarse powder, add the water of coarse powder total amount 10 times amount and the cellulase of coarse powder total amount 1%, PH is regulated to be 4.50, lixiviate 2 hours at 50 DEG C, then 80 DEG C of reflux, extract, 2 hours, filter, filtrate and described Folium Ginkgo extract merge, and being evaporated to relative density at 60 DEG C after mix homogeneously is the extractum of 1.10;
S4: mixed with the extractum of S3 gained by described Folium Ginkgo residue, drying under reduced pressure, pulverizes, and crosses 80 mesh sieves, to obtain final product.
Embodiment 2
The embodiment of the present invention 2 Chinese medicine preparation is prepared from by the raw material of following parts by weight:
Folium Artemisiae Argyi 25 parts, Rhizoma Et Radix Notopterygii 28 parts, Caulis Sinomenii 22 parts, the Radix Astragali 23 parts, umbrella plant 22 parts, Herba Schisandrae intermediae 20 parts, Folium Ginkgo 20 parts, Radix Puerariae 16 parts, Rhizoma Dioscoreae 16 parts, Herba Epimedii 18 parts, Radix Rhodiolae 15 parts, the Radix Aucklandiae 15 parts and 15 parts, Radix Glycyrrhizae.
Preparation method:
S1: get Folium Artemisiae Argyi, Rhizoma Et Radix Notopterygii, Caulis Sinomenii, the Radix Astragali, umbrella plant, Herba Schisandrae intermediae, Folium Ginkgo, Radix Puerariae, Rhizoma Dioscoreae, Herba Epimedii, Radix Rhodiolae, the Radix Aucklandiae and Radix Glycyrrhizae, wash away impurity, pulverize respectively after drying, crosses 80 mesh sieves, for subsequent use;
S2: get Folium Ginkgo coarse powder, be placed in supercritical carbon dioxide extraction apparatus, adding coarse powder total amount 45% volume fraction is the ethanol of 85%, regulation and control carbon dioxide flow is 20L/h, extracting pressure is 20MPa, and extraction temperature is 60 DEG C, and extraction time is 1.5h, decompression separation obtains Folium Ginkgo extract, retains Folium Ginkgo residue;
S3: get Folium Artemisiae Argyi, Rhizoma Et Radix Notopterygii, Caulis Sinomenii, the Radix Astragali, umbrella plant, Herba Schisandrae intermediae, Radix Puerariae, Rhizoma Dioscoreae, Herba Epimedii, Radix Rhodiolae, the Radix Aucklandiae and Radix Glycyrrhizae coarse powder, add the water of coarse powder total amount 12 times amount and the cellulase of coarse powder total amount 2.5%, PH is regulated to be 5.0, lixiviate 1 hour at 65 DEG C, then 95 DEG C of reflux, extract, 1 hour, filter, filtrate and described Folium Ginkgo extract merge, and being evaporated to relative density at 60 DEG C after mix homogeneously is the extractum of 1.25;
S4: mixed with the extractum of S3 gained by described Folium Ginkgo residue, drying under reduced pressure, pulverizes, and crosses 100 mesh sieves, to obtain final product.
Embodiment 3
The embodiment of the present invention 3 Chinese medicine preparation is prepared from by the raw material of following parts by weight:
Folium Artemisiae Argyi 22 parts, Rhizoma Et Radix Notopterygii 26 parts, Caulis Sinomenii 20 parts, the Radix Astragali 20 parts, umbrella plant 18 parts, Herba Schisandrae intermediae 18 parts, Folium Ginkgo 18 parts, Radix Puerariae 14 parts, Rhizoma Dioscoreae 12 parts, Herba Epimedii 15 parts, Radix Rhodiolae 13 parts, the Radix Aucklandiae 12 parts and 15 parts, Radix Glycyrrhizae.
Preparation method:
S1: get Folium Artemisiae Argyi, Rhizoma Et Radix Notopterygii, Caulis Sinomenii, the Radix Astragali, umbrella plant, Herba Schisandrae intermediae, Folium Ginkgo, Radix Puerariae, Rhizoma Dioscoreae, Herba Epimedii, Radix Rhodiolae, the Radix Aucklandiae and Radix Glycyrrhizae, wash away impurity, pulverize respectively after drying, crosses 70 mesh sieves, for subsequent use;
S2: get Folium Ginkgo coarse powder, be placed in supercritical carbon dioxide extraction apparatus, adding coarse powder total amount 40% volume fraction is the ethanol of 75%, regulation and control carbon dioxide flow is 18L/h, extracting pressure is 18MPa, and extraction temperature is 50 DEG C, and extraction time is 1.5h, decompression separation obtains Folium Ginkgo extract, retains Folium Ginkgo residue;
S3: get Folium Artemisiae Argyi, Rhizoma Et Radix Notopterygii, Caulis Sinomenii, the Radix Astragali, umbrella plant, Herba Schisandrae intermediae, Radix Puerariae, Rhizoma Dioscoreae, Herba Epimedii, Radix Rhodiolae, the Radix Aucklandiae and Radix Glycyrrhizae coarse powder, add the water of coarse powder total amount 11 times amount and the cellulase of coarse powder total amount 2%, PH is regulated to be 4.50, lixiviate 1.5 hours at 60 DEG C, then 90 DEG C of reflux, extract, 1.5 hours, filter, filtrate and described Folium Ginkgo extract merge, and being evaporated to relative density at 60 DEG C after mix homogeneously is the extractum of 1.20;
S4: mixed with the extractum of S3 gained by described Folium Ginkgo residue, drying under reduced pressure, pulverizes, and crosses 100 mesh sieves, to obtain final product.
Experimental example 1, Chinese medicine preparation of the present invention are to the experimental study of the rat pain lured caused by pain agent acetic acid
1, experimental animal: get regular grade SD rat 90, body weight (180 ± 15g), male and female half and half, are divided into 9 groups at random, often organize 10.
2, trial drug and dosage regimen:
A group: trial drug is the Chinese medicine preparation of the present invention that the embodiment of the present invention 2 obtains.Get 3 groups of rats, be labeled as A group high dose group (1000mg/kg), middle dosage group (800mg/kg) and low dose group (600mg/kg), modeling according to dosage smears 3 times in Test sites in first 2 days every day, and modeling is implemented to smear for the last time for first 1 hour.
B group: trial drug is that in the present invention, embodiment 3 obtains Chinese medicine preparation of the present invention, get 3 groups of rats, be labeled as B group high dose group (1000mg/kg), middle dosage group (800mg/kg) and low dose group (600mg/kg), dosage regimen is with A group.
Model control group: get 1 group of rat, first 2 days of modeling, smears 3 times in Test sites by equal-volume normal saline every day, and modeling is implemented to smear for the last time for first 1 hour.
Positive controls: positive control drug is YUNNAN BAIYAO cream (the accurate word Z20073015 of traditional Chinese medicines, Yunnan Baiyao Group Wuxi Medicine Co., Ltd.), medicine is smeared 3 times in Test sites by suggestion using dosage every day, and modeling is implemented to smear for the last time for first 1 hour.
3, experimentation: the cervical region of experimental rat, waist 8% sodium sulfide saturated solution are lost hair or feathers, depilation area cervical region is about 1.3cm × 1.1cm, and waist is about 2.2cm × 1.6cm.1h after last administration, every Mus lumbar injection 0.7% glacial acetic acid 0.1ml/10g, after observed and recorded injection glacial acetic acid, rat starts to occur incubation period and the writhing number of times of rat in 30min after there is pain reaction of pain reaction.
4, result of the test: as shown in table 1.
The impact of the rat pain caused by table 1 Chinese medicine preparation Dichlorodiphenyl Acetate of the present invention
Note: compare with model control group, positive controls
△ △p < 0.01; Compare with model control group, Chinese medicine preparation drug test group of the present invention
*p < 0.01; Compare with positive controls, Chinese medicine preparation drug test group of the present invention
##p < 0.01.
5, conclusion (of pressure testing): can be found out by the result of the test of table 1, compare with model control group, there were significant differences to the treatment of hyperosteogeny for the high and low dose of Chinese medicine preparation of the present invention, in the present invention, experimental administration A group (Chinese medicine preparation that namely embodiment of the present invention 2 is obtained) middle and high dosage group and Chinese medicine preparation B group of the present invention (Chinese medicine preparation of the present invention that namely embodiment of the present invention 3 is obtained) basic, normal, high dosage group experiment effect obviously, can significantly improve experimental rat incubation period and pain threshold.Wherein Chinese medicine preparation B group of the present invention (Chinese medicine preparation of the present invention that namely embodiment of the present invention 3 is obtained) high dose group best results, incubation period is the longest, twisting least number of times in certain hour, there is obvious analgesic effect, therapeutic effect is better than positive control, and difference has statistical significance (P < 0.01).
The clinical trial of experimental example 2, Chinese medicine preparation of the present invention
(1) study subject is selected
Tcm diagnosis standard: the content of " hyperosteogeny " of reference " Chinese medical disease Standardization of diagnosis and curative effect " (2012 editions) and " new Chinese medicine guideline of clinical investigations " is drafted.Diagnostic criteria is:
1. suffering oppression and irritation appears in diseased region, and wherein cervical spondylosis patient has long-term neck shoulder and back ache, dizziness headache, the numb or symptom such as unfavorable of changing one's position of both hands.
2. x-ray to take the photograph in sheet visible cervical vertebra just, lateral projection, left and right oblique film, cervical vertebrae physiological is bending to be straightened or instead to bend, prolapse of lumbar intervertebral disc, intervertebral foramina stenosis, vertebral body hyperosteogeny; The positive side of knee joint is visible: proximal ends of tibia, and the interior lateral condyle hyperosteogeny of distal part of femur is formed, lower edge, spinous process of tibia on patella, and calcaneal tuberosity bony spur is formed.
1, physical data
Choose in January, 2012 ~ 2014 year January the medical patient of Orthopaedics Clinic totally 200 routine hyperosteogeny patients be divided into two groups at random, often organize 100 examples, age 22-76 year, 43.1 years old mean age.Two groups of patients no difference of science of statistics (P > 0.05) in age, sex, disease time, previously health history, ordinary circumstance etc. has comparability.
2, test method
Treatment group: trial drug is Chinese medicine preparation plaster of the present invention prepared by the embodiment of the present invention 3, every day three times, 7 days is a course for the treatment of, evaluates curative effect after 2 courses for the treatment of.
Matched group: matched group YUNNAN BAIYAO spray (the accurate word Z20025478 of traditional Chinese medicines), every day three times, 7 days is a course for the treatment of, evaluates curative effect after 2 courses for the treatment of.
3, curative effect determinate standard
Criterion of therapeutical effect: with reference to " practical combination of Chinese and Western medicine diagnoses and treatment " muscle tendon soft tissue injury criterion of therapeutical effect.
1. invalid: before and after treatment, sings and symptoms is not any change, or aggravation.
2. effective: the improvement of condition of illness and sign limited extent, the recovery of function limited extent.
3. remarkable: condition of illness and sign disappear substantially, functional rehabilitation is normal, but still can go out sense of discomfort because of Changes in weather or tired etc.
4. fully recover: condition of illness and sign disappear completely, and function recovers normal completely.
4, therapeutic outcome: as shown in table 2
Table 2 therapeutic effect
This clinical trial matched group is the medicine YUNNAN BAIYAO cream of conventional treatment muscle tendon soft tissue injury, and compared by the treatment clinical effectiveness of itself and Chinese medicine preparation of the present invention, result of the test illustrates that the evident in efficacy of Chinese medicine preparation of the present invention is better than matched group medicine.Clinical testing data shows, and the effect cure rate of matched group Drug therapy hyperosteogeny reaches 35.0%; And Chinese medicine preparation treatment hyperosteogeny effect recovery from illness efficiency of the present invention is up to 44.0%, total effective rate is 98.0%, apparently higher than the total effective rate of contrast medicine 81.0%.Clinical trial results proves Chinese medicine preparation of the present invention treatment hyperosteogeny Be very effective, and have reducing swelling and alleviating pain curative effect, can be used as clinical treatment hyperosteogeny medicine and use, clinical generalization value is high.
Claims (6)
1. a Chinese medicine preparation for curing hyperosteogeny for external application, is characterized in that, described Chinese medicine preparation forms primarily of the raw material of following parts by weight:
Folium Artemisiae Argyi 18-25 part, Rhizoma Et Radix Notopterygii 20-28 part, Caulis Sinomenii 16-22 part, Radix Astragali 17-23 part, umbrella plant 14-22 part, Herba Schisandrae intermediae 15-20 part, Folium Ginkgo 14-20 part, Radix Puerariae 12-16 part, Rhizoma Dioscoreae 8-16 part, Herba Epimedii 12-18 part, Radix Rhodiolae 9-15 part, Radix Aucklandiae 9-15 part and Radix Glycyrrhizae 10-15 part.
2. the Chinese medicine preparation of curing hyperosteogeny for external application as claimed in claim 1, it is characterized in that, described Chinese medicine preparation forms primarily of the raw material of following parts by weight:
Folium Artemisiae Argyi 18 parts, Rhizoma Et Radix Notopterygii 20 parts, Caulis Sinomenii 16 parts, the Radix Astragali 17 parts, umbrella plant 14 parts, Herba Schisandrae intermediae 15 parts, Folium Ginkgo 14 parts, Radix Puerariae 12 parts, Rhizoma Dioscoreae 8 parts, Herba Epimedii 12 parts, Radix Rhodiolae 9 parts, the Radix Aucklandiae 9 parts and 10 parts, Radix Glycyrrhizae.
3. the Chinese medicine preparation of curing hyperosteogeny for external application as claimed in claim 1, it is characterized in that, described Chinese medicine preparation forms primarily of the raw material of following parts by weight:
Folium Artemisiae Argyi 25 parts, Rhizoma Et Radix Notopterygii 28 parts, Caulis Sinomenii 22 parts, the Radix Astragali 23 parts, umbrella plant 22 parts, Herba Schisandrae intermediae 20 parts, Folium Ginkgo 20 parts, Radix Puerariae 16 parts, Rhizoma Dioscoreae 16 parts, Herba Epimedii 18 parts, Radix Rhodiolae 15 parts, the Radix Aucklandiae 15 parts and 15 parts, Radix Glycyrrhizae.
4. the Chinese medicine preparation of curing hyperosteogeny for external application as claimed in claim 1, it is characterized in that, described Chinese medicine preparation forms primarily of the raw material of following parts by weight:
Folium Artemisiae Argyi 22 parts, Rhizoma Et Radix Notopterygii 26 parts, Caulis Sinomenii 20 parts, the Radix Astragali 20 parts, umbrella plant 18 parts, Herba Schisandrae intermediae 18 parts, Folium Ginkgo 18 parts, Radix Puerariae 14 parts, Rhizoma Dioscoreae 12 parts, Herba Epimedii 15 parts, Radix Rhodiolae 13 parts, the Radix Aucklandiae 12 parts and 15 parts, Radix Glycyrrhizae.
5. the Chinese medicine preparation of the curing hyperosteogeny for external application as described in as arbitrary in claim 1-4, it is characterized in that, described Chinese medicine preparation is made into ointment or emplastrum.
6. the preparation method of the Chinese medicine preparation of the curing hyperosteogeny for external application as described in as arbitrary in claim 1-4, it is characterized in that, the preparation method of described Chinese medicine preparation comprises following steps:
S1: get Folium Artemisiae Argyi, Rhizoma Et Radix Notopterygii, Caulis Sinomenii, the Radix Astragali, umbrella plant, Herba Schisandrae intermediae, Folium Ginkgo, Radix Puerariae, Rhizoma Dioscoreae, Herba Epimedii, Radix Rhodiolae, the Radix Aucklandiae and Radix Glycyrrhizae, wash away impurity, pulverize respectively after drying, crosses 60-80 mesh sieve, for subsequent use;
S2: get Folium Ginkgo coarse powder, be placed in supercritical carbon dioxide extraction apparatus, adding coarse powder total amount 30-45% volume fraction is the ethanol of 60-85%, regulation and control carbon dioxide flow is 15-20L/h, extracting pressure is 15-20MPa, and extraction temperature is 40-60 DEG C, and extraction time is 1.5-2h, decompression separation obtains Folium Ginkgo extract, retains Folium Ginkgo residue;
S3: get Folium Artemisiae Argyi, Rhizoma Et Radix Notopterygii, Caulis Sinomenii, the Radix Astragali, umbrella plant, Herba Schisandrae intermediae, Radix Puerariae, Rhizoma Dioscoreae, Herba Epimedii, Radix Rhodiolae, the Radix Aucklandiae and Radix Glycyrrhizae coarse powder, add the water of coarse powder total amount 10-12 times amount and the cellulase of coarse powder total amount 1%-2.5%, adjustment PH is 4.50-5.0, lixiviate 1-2 hour at 50-65 DEG C, then at 80-95 DEG C of reflux, extract, 1-2 hour, filter, filtrate and described Folium Ginkgo extract merge, and being evaporated to relative density at 60 DEG C after mix homogeneously is the extractum of 1.10-1.25;
S4: mixed with the extractum of S3 gained by described Folium Ginkgo residue, drying under reduced pressure, pulverizes, and crosses 80-100 mesh sieve, to obtain final product.
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Application publication date: 20160106 |