CN105213646A - For the Chinese medicine composition and preparation method thereof of injury of sciatic nerve postoperative rehabilitation - Google Patents

Abstract

The invention discloses the Chinese medicine composition and preparation method thereof for injury of sciatic nerve postoperative rehabilitation, this Chinese medicine composition comprise Tarenna mollissima (Hook. et Arn.) Robins., shamrock, Bud root, Canis familiaris L. ant grass, Radix seu folium abelmoschi moschati, tap grass, Semen Sojae Preparatum seven, white tripe, sting tea Folium Mayteni hookeri, the winter department, phlegmariurus hamictonii (Sprengel) Love et love varpeti-olaius (Clarke) Ching, Cissus repens, Herba saniculae orthacanthae, Tibet chicken feet showy flowers of herbaceous plants, Radix rubi Xanthocarpi, bamboo rat seed oil, Radix Anemones Tomentosae, moray.By each medicine various trait, by Tarenna mollissima (Hook. et Arn.) Robins., shamrock, Bud root, Canis familiaris L. ant grass, Radix seu folium abelmoschi moschati, tap grass, Semen Sojae Preparatum seven, white tripe, thorn tea Folium Mayteni hookeri, flatstiped corydalis herb, phlegmariurus hamictonii (Sprengel) Love et love varpeti-olaius (Clarke) Ching, Radix Cissi Kerrii, Herba saniculae orthacanthae, Tibet chicken feet showy flowers of herbaceous plants, Radix rubi Xanthocarpi, Radix Anemones Tomentosae water boiling and extraction, moray levigation bamboo rat seed oil is allocated, all medicated powder slags add flocculating agent chitosan flocculation separation technology and purify after obtaining extracting solution after filtering, extract obtained lyophilization, adds adjuvant and makes externally applied liniment after pulverizing.Formula of the present invention is reasonable, and drug effect can go deep into focus lastingly, evident in efficacy, has no side effect.

Description

For the Chinese medicine composition and preparation method thereof of injury of sciatic nerve postoperative rehabilitation

Technical field

The present invention relates to technical field of Chinese medicines, particularly relate to the Chinese medicine composition and preparation method thereof for injury of sciatic nerve postoperative rehabilitation.

Background technology

Injury of sciatic nerve is clinical common disease, and as can not get effective treatment, end-stage disease can cause the relevant diseases such as nervous disorder, amyotrophy, paralysis, has a strong impact on the quality of life of patient.Sciatic nerve is waist marrow 4,5 and sacrum marrow 1,2,3 nerve root composition.Damage reason differs, and how being caused by thigh or buttocks firearm injury, dislocation of hip and fracture of pelvis also can merge injury of sciatic nerve sometimes.Drug injection damage is also not rare.During fracture, muscle panplegia ， Dan hamstring General Influence is little below knee completely, as then shown as the partial paralysis of common peroneal nerve or tibial nerve for partial injury.Although nerve injury surgical repair is necessary, postoperatively wound infection, suppuration, pain and the symptom such as handicapped may be there is, so postoperative care also has important effect to patients ' recovery.We main blood circulation promoting and blood stasis dispelling, evacuation of pus detumescence, anti-inflammatory analgetic, fill blood, repair nerve, for preventing and treating injury of sciatic nerve postoperative infection, ulcer, pain and the symptom such as handicapped.Have healing fast, have no side effect, the advantages such as safe ready, extend to the nursing of injury of sciatic nerve postoperative rehabilitation clinically.

Summary of the invention

The invention provides a kind of good effect, instant effect, have no side effect, the Chinese medicine composition for injury of sciatic nerve postoperative rehabilitation easy to use.

Another object of the present invention is to provide the preparation method of the described Chinese medicine composition for injury of sciatic nerve postoperative rehabilitation.

For realizing above-mentioned first object, technical scheme of the present invention is: for the Chinese medicine composition of injury of sciatic nerve postoperative rehabilitation, component meter is made up of following raw material by weight: Tarenna mollissima (Hook. et Arn.) Robins. 45-65 part, shamrock 42-60 part, Bud root 38-56 part, Canis familiaris L. ant grass 35-53 part, Radix seu folium abelmoschi moschati 31-50 part, the careless 30-46 part of tap, Semen Sojae Preparatum seven 28-40 part, white tripe 20-35 part, thorn tea Folium Mayteni hookeri 18-32 part, winter department 17-30 part, phlegmariurus hamictonii (Sprengel) Love et love varpeti-olaius (Clarke) Ching 15-27 part, Cissus repens 13-25 part, Herba saniculae orthacanthae 12-24 part, Tibet chicken feet showy flowers of herbaceous plants 11-22 part, Radix rubi Xanthocarpi 10-20 part, bamboo rat seed oil 8-18 part, Radix Anemones Tomentosae 3-10 part, moray 2-8 part.

Further, the described Chinese medicine composition for injury of sciatic nerve postoperative rehabilitation, component meter is made up of following raw material by weight: Tarenna mollissima (Hook. et Arn.) Robins. 55 parts, shamrock 51 parts, Bud root 47 parts, Canis familiaris L. ant grass 44 parts, Radix seu folium abelmoschi moschati 40.5 parts, tap grass 38 parts, Semen Sojae Preparatum 7 34 parts, white 27.5 parts, tripe, thorn tea Folium Mayteni hookeri 25 parts, the winter 23.5 parts, department, phlegmariurus hamictonii (Sprengel) Love et love varpeti-olaius (Clarke) Ching 21 parts, Cissus repens 19 parts, Herba saniculae orthacanthae 18 parts, Tibet chicken feet showy flowers of herbaceous plants 16.5 parts, Radix rubi Xanthocarpi 15 parts, bamboo rat seed oil 13 parts, Radix Anemones Tomentosae 6.5 parts, moray 5 parts.

Further, the described Chinese medicine composition for injury of sciatic nerve postoperative rehabilitation, also comprises following adjuvant: pregelatinized Starch 3-9 part, magnesium stearate 3-8 part, boric acid 2-5 part, Mirabilitum 1-6 part, compound vitamin 0.025-0.049 part.

In described adjuvant, pregelatinized Starch is modified starch, mixes can make lubricant with magnesium stearate; Boric acid is external antibacterial, disinfectant and antiseptic, can suppress various bacteria, prevents medicament from going bad; Mirabilitum salty in the mouth, hardship, cold in nature, there is the effect of detumescence of relieving inflammation or internal heat.Described compound vitamin is vitamin B1, vitamin B6 and vitamin B12, its by weight component count: vitaminB10 .012-0.024 part, vitamin B6 0.006-0.012 part, vitamin B12 0.007-0.013 part.Vitamin B1, vitamin B6 and vitamin B12 can trophic nervees, improve nervous function, promote human metabolism, help medicine better to absorb.

Further, described adjuvant by weight component meter comprise: pregelatinized Starch 6 parts, magnesium stearate 5.5 parts, boric acid 3.5 parts, Mirabilitum 4.5 parts, compound vitamin 0.037 part.

Further, described Tarenna mollissima (Hook. et Arn.) Robins., shamrock, Semen Sojae Preparatum seven, thorn tea Folium Mayteni hookeri, phlegmariurus hamictonii (Sprengel) Love et love varpeti-olaius (Clarke) Ching are fresh goods.The effective ingredient of fresh goods is not destroyed or wander away, and in the extracting solution that after parch, soak by water obtains, effective ingredient reservation is more.

Further, the dosage form of the described Chinese medicine composition for injury of sciatic nerve postoperative rehabilitation is externally applied liniment.

For realizing above-mentioned second object, the technical scheme that the present invention takes is:

For the preparation method of the Chinese medicine composition of injury of sciatic nerve postoperative rehabilitation, comprise the following steps:

(1) Tarenna mollissima (Hook. et Arn.) Robins. of formula ratio, shamrock, Semen Sojae Preparatum seven, thorn tea Folium Mayteni hookeri, phlegmariurus hamictonii (Sprengel) Love et love varpeti-olaius (Clarke) Ching fresh goods is got, smashed to pieces respectively and mixed, be placed in frying pan moderate heat to stir-fry the water added after 10min relative to mixture 12 ~ 15 times amount, big fire is boiled, change little fire decoction extraction 3 ~ 5h filtration and obtain filtering residue and filtrate a, filtering residue enters juice extractor and squeezes and filter and obtain filtrate b, merging filtrate a and filtrate b, impurity is removed with resin adsorption method, heating is concentrated into pasty state, and after putting into the oven dry of 79 DEG C, baking oven, room temperature cools, grind to form fine powder, cross 200 mesh sieves;

(2) get the Bud root of formula ratio, Canis familiaris L. ant grass, Radix seu folium abelmoschi moschati, tap grass, white tripe, the winter department, Cissus repens, Herba saniculae orthacanthae, Tibet chicken feet showy flowers of herbaceous plants, Radix rubi Xanthocarpi, Radix Anemones Tomentosae mix, add water and do not have mixture to soak 40-60min, big fire is poured into after boiling 30min in marmite and is decocted 3-5h with little fire, stir 4-6 time in process, extracting solution is obtained after filtration, flocculating agent chitosan is added sedimentation filtration in extracting solution and obtains cotton-shaped semi-finished product, for subsequent use; Chinese medicine flocculation separation technology produces cohesion by the absorption of flocculating agent, bridge formation, flocculation and inorganic salt electrolyte particulates and surface charge in Aqueous extracts flocculating agent being added to Chinese medicine, the microgranule of many instability such as protein, manganese liquid matter, natural gum, saddle matter etc. are made to connect into floc sedimentation sedimentation, through filtering the object reaching separation and purification.Use flocculating agent can retain effective ingredient largely, safety non-toxic, easy and simple to handle;

(3) moray and the bamboo rat seed oil of formula ratio is got, by the bamboo rat seed oil allotment of moray levigation, for subsequent use;

(4) semi-finished product mixing above-mentioned steps (1), (2), (3) obtained, add pregelatinized Starch, stearic acid, compound vitamin in mass ratio, after again Mirabilitum water being melted in the ratio of 1:5, add wherein, heat and stir into paste, sterilizing, cooling, packaging, makes liniment.

The pharmacologically active of each raw material of Chinese medicine of the present invention is as follows:

Tarenna mollissima (Hook. et Arn.) Robins.: [nature and flavor] micro-hardship, cool.[function cures mainly] heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Root: cure mainly cold, fever, cough, hot stomachache, colicky, sciatica.

Shamrock: [nature and flavor] are sweet, micro-puckery, flat.[function cures mainly] clearing away heat-damp and promoting diuresis, cooling blood for hemostasis, relaxing muscles and tendons and activating QI and blood in the collateral; For icterohepatitis, have blood in stool, bleeding hemorrhoids, leukemia, sciatica, rheumatic ostalgia, lumbar muscle strain.

Bud root: [nature and flavor] are sweet; Flat.[function cures mainly] dampness removing jaundice eliminating, promoting blood circulation to remove obstruction in the collateral, removing toxic substances and promoting subsidence of swelling; Main icterohepatitis, rheumatic arthralgia, traumatic injury, carbuncle.

Canis familiaris L. ant grass: [nature and flavor] are sweet, bitter is flat.[function cures mainly] promoting blood circulation to remove obstruction in the collateral, clearing away heat and eliminating dampness, refutes atrophic debility of bones and swells, removing the necrotic tissue and promoting granulation.

Radix seu folium abelmoschi moschati: [nature and flavor] are micro-sweet, cool.[function cures mainly] clearing away heat-damp and promoting diuresis, evacuation of pus of drawing out pus by applying a plaster to the affected part.

Tap grass: [nature and flavor] sweet in the mouth; Pungent; Property is put down.[function cures mainly] fills blood, wind-damp dispelling, detumescence poison; Main impairment caused by overstrain deficiency of qi and blood, epigastric pain, laryngopharynx swelling and pain, snakebite.

Semen Sojae Preparatum seven: [nature and flavor] are bitter; Cold in nature.[function cures mainly] promoting blood circulation to remove obstruction in the collateral, reducing swelling and alleviating pain, heat-clearing and toxic substances removing; Main air pain of dampness syndrome, traumatic injury, fracture, traumatic hemorrhage, ulcer sore pain.

White tripe: [nature and flavor] are pungent; Flat.[function cures mainly] promoting blood circulation to remove obstruction in the collateral.Main rheumatalgia, treating swelling and pain by traumatic injury.

Thorn tea Folium Mayteni hookeri: [nature and flavor] are bitter; Pungent; Be slightly cold.[function cures mainly] detoxifies, and dampness is anticancer; Main ulcer of the lower limb, tinea capitis, psoriasis, tumor.

Winter department: [nature and flavor] are bitter, cold.[function cures mainly] antipyretic analgesic; Cure mainly gastritis, Peptic Ulcers, dysentery, the diseases such as sciatica.

Phlegmariurus hamictonii (Sprengel) Love et love varpeti-olaius (Clarke) Ching: [function cures mainly] promoting blood circulation to remove obstruction in the collateral, inducing diuresis and reducing edema; Main traumatic injury, lumbago, edema.

Cissus repens: [nature and flavor] sweetness and bitterness is cool.[function cures mainly] heat-clearing and toxic substances removing, eliminating stagnation, promoting the circulation of blood; Control nephritis, ulcer sores, tuberculous lymphadenitis, traumatic injury.

Herba saniculae orthacanthae: [nature and flavor] are bitter, temperature.[function cures mainly]: heat clearing away, removing toxic substances.After controlling measles, pyretic toxicity is not to the greatest extent, pruritus of having burning ears, traumatic injury.

Tibet chicken feet showy flowers of herbaceous plants: [nature and flavor] acrid in the mouth, micro-hardship, cold.[function cures mainly] is antipyretic, evacuation of pus; Main irritable feverish sensation in the chest, wound is suppurated.

Radix rubi Xanthocarpi: [nature and flavor] acid, is slightly cold.[function cures mainly] anti-inflammatory analgetic, controls conjunctivitis, blepharitis, innominate toxic swelling.

Bamboo rat seed oil: [nature and flavor] are lightly seasoned sweet, property is put down.[function cures mainly] removing toxic substances and promoting pus discharge, granulation promoting pain relieving; Control scald, innominate toxic swelling, foreign body of choosing.

Radix Anemones Tomentosae: [nature and flavor] are bitter, temperature, slightly poisonous.[function cures mainly] reduces phlegm, dissipating blood stasis, preventing the attack (or recurrence) of malaria, parasite killing; Control furuncle carbuncle, stubborn dermatitis, tinea alba, malaria, dysentery, impairment caused by overstrain cough with asthma, infant malnutrition, traumatic injury.

Moray: [nature and flavor] acrid in the mouth, sweet, warm in nature, poisonous.[function cures mainly] removing toxic substances and promoting subsidence of swelling, analgesic hemostatic; Main hemorrhoid, innominate toxic swelling, chest pain, sciatica, traumatic hemorrhage.

Beneficial effect of the present invention is embodied in: the formula of Chinese materia medica preparation that the present invention is used for the treatment of injury of sciatic nerve postoperative rehabilitation is reasonable, there is effect of promoting blood circulation to remove obstruction in the collateral, trophic nerve, evacuation of pus detumescence, anti-inflammation and sterilization, and drug effect can go deep into focus lastingly, evident in efficacy, have no side effect, for preventing and treating injury of sciatic nerve postoperative infection, ulcer, pain and the symptom such as handicapped.

Detailed description of the invention

Below in conjunction with detailed description of the invention, the present invention is described in more detail:

Embodiment 1: for the Chinese medicine composition of injury of sciatic nerve postoperative rehabilitation, component meter is made up of following raw material by weight: Tarenna mollissima (Hook. et Arn.) Robins. 45 parts, shamrock 42 parts, Bud root 38 parts, Canis familiaris L. ant grass 35 parts, Radix seu folium abelmoschi moschati 31 parts, tap grass 30 parts, Semen Sojae Preparatum 7 28 parts, white 20 parts, tripe, thorn tea Folium Mayteni hookeri 18 parts, the winter 17 parts, department, phlegmariurus hamictonii (Sprengel) Love et love varpeti-olaius (Clarke) Ching 15 parts, Cissus repens 13 parts, Herba saniculae orthacanthae 12 parts, Tibet chicken feet showy flowers of herbaceous plants 11 parts, Radix rubi Xanthocarpi 10 parts, bamboo rat seed oil 8 parts, Radix Anemones Tomentosae 3 parts, moray 2 parts; Also comprise following adjuvant: pregelatinized Starch 3 parts, magnesium stearate 3 parts, boric acid 2 parts, Mirabilitum 1 part, compound vitamin 0.025 part.

In described adjuvant, pregelatinized Starch is modified starch, mixes can make lubricant with magnesium stearate; Boric acid is external antibacterial, disinfectant and antiseptic, can suppress various bacteria, prevents medicament from going bad; Mirabilitum salty in the mouth, hardship, cold in nature, there is the effect of detumescence of relieving inflammation or internal heat.Described compound vitamin is vitamin B1, vitamin B6 and vitamin B12, its by weight component count: vitaminB10 .012 part, vitamin B6 0.006 part, vitamin B12 0.007 part, vitamin B1, vitamin B6 and vitamin B12 can trophic nervees, improve nervous function, promote human metabolism, help the better absorption of medicine.

Preparation method for the externally applied liniment of the Chinese medicine composition of injury of sciatic nerve postoperative rehabilitation is:

(1) Tarenna mollissima (Hook. et Arn.) Robins. of formula ratio, shamrock, Semen Sojae Preparatum seven, thorn tea Folium Mayteni hookeri, phlegmariurus hamictonii (Sprengel) Love et love varpeti-olaius (Clarke) Ching fresh goods is got, smashed to pieces respectively and mixed, be placed in frying pan moderate heat to stir-fry the water added after 10min relative to mixture 12 times amount, big fire is boiled, change little fire decoction extraction filtration in 3 hours and obtain filtering residue and filtrate a, filtering residue enters juice extractor and squeezes and filter and obtain filtrate b, merging filtrate a and filtrate b, impurity is removed with resin adsorption method, heating is concentrated into pasty state, and after putting into the oven dry of 79 DEG C, baking oven, room temperature cools, grind to form fine powder, cross 200 mesh sieves;

(2) get the Bud root of formula ratio, Canis familiaris L. ant grass, Radix seu folium abelmoschi moschati, tap grass, white tripe, the winter department, Cissus repens, Herba saniculae orthacanthae, Tibet chicken feet showy flowers of herbaceous plants, Radix rubi Xanthocarpi, Radix Anemones Tomentosae mix, add water and do not have mixture to soak 40min, big fire is poured into after boiling 30min in marmite and is decocted 3h with little fire, stirs 4 times in process; Obtain extracting solution after filtration, flocculating agent chitosan is added sedimentation filtration in extracting solution and obtains cotton-shaped semi-finished product, for subsequent use; Chinese medicine flocculation separation technology produces cohesion by the absorption of flocculating agent, bridge formation, flocculation and inorganic salt electrolyte particulates and surface charge in Aqueous extracts flocculating agent being added to Chinese medicine, the microgranule of many instability such as protein, manganese liquid matter, natural gum, saddle matter etc. are made to connect into floc sedimentation sedimentation, through filtering the object reaching separation and purification.Use flocculating agent can retain effective ingredient largely, safety non-toxic, easy and simple to handle;

(3) moray and the bamboo rat seed oil of formula ratio is got, by the bamboo rat seed oil allotment of moray levigation, for subsequent use;

(4) semi-finished product mixing above-mentioned steps (1), (2), (3) obtained, add pregelatinized Starch, stearic acid, compound vitamin in mass ratio, after again Mirabilitum water being melted in the ratio of 1:5, add wherein, heat and stir into paste, sterilizing, cooling, packaging, makes liniment.

Embodiment 2: for the Chinese medicine composition of injury of sciatic nerve postoperative rehabilitation, component meter is made up of following raw material by weight: Tarenna mollissima (Hook. et Arn.) Robins. 55 parts, shamrock 51 parts, Bud root 47 parts, Canis familiaris L. ant grass 44 parts, Radix seu folium abelmoschi moschati 40.5 parts, tap grass 38 parts, Semen Sojae Preparatum 7 34 parts, white 27.5 parts, tripe, thorn tea Folium Mayteni hookeri 25 parts, the winter 23.5 parts, department, phlegmariurus hamictonii (Sprengel) Love et love varpeti-olaius (Clarke) Ching 21 parts, Cissus repens 19 parts, Herba saniculae orthacanthae 18 parts, Tibet chicken feet showy flowers of herbaceous plants 16.5 parts, Radix rubi Xanthocarpi 15 parts, bamboo rat seed oil 13 parts, Radix Anemones Tomentosae 6.5 parts, moray 5 parts.Also comprise following adjuvant: pregelatinized Starch 6 parts, magnesium stearate 5.5 parts, boric acid 3.5 parts, Mirabilitum 4.5 parts.Compound vitamin 0.037 part.

In described adjuvant, pregelatinized Starch is modified starch, mixes can make lubricant with magnesium stearate; Boric acid is external antibacterial, disinfectant and antiseptic, can suppress various bacteria, prevents medicament from going bad; Mirabilitum salty in the mouth, hardship, cold in nature, there is the effect of detumescence of relieving inflammation or internal heat.Described compound vitamin is vitamin B1, vitamin B6 and vitamin B12, its by weight component count: vitaminB10 .018 part, vitamin B6 0.009 part, vitamin B12 0.010 part.Vitamin B1, vitamin B6 and vitamin B12 can trophic nervees, improve nervous function, promote human metabolism, help the better absorption of medicine.

Preparation method for the externally applied liniment of the Chinese medicine composition of injury of sciatic nerve postoperative rehabilitation is:

(1) Tarenna mollissima (Hook. et Arn.) Robins. of formula ratio, shamrock, Semen Sojae Preparatum seven, thorn tea Folium Mayteni hookeri, phlegmariurus hamictonii (Sprengel) Love et love varpeti-olaius (Clarke) Ching fresh goods is got, smashed to pieces respectively and mixed, be placed in frying pan moderate heat to stir-fry the water added after 10min relative to mixture 13.5 times amount, big fire is boiled, change little fire decoction extraction filtration in 4 hours and obtain filtering residue and filtrate a, filtering residue enters juice extractor and squeezes and filter and obtain filtrate b, merging filtrate a and filtrate b, impurity is removed with resin adsorption method, heating is concentrated into pasty state, and after putting into the oven dry of 79 DEG C, baking oven, room temperature cools, grind to form fine powder, cross 200 mesh sieves;

(2) get the Bud root of formula ratio, Canis familiaris L. ant grass, Radix seu folium abelmoschi moschati, tap grass, white tripe, the winter department, Cissus repens, Herba saniculae orthacanthae, Tibet chicken feet showy flowers of herbaceous plants, Radix rubi Xanthocarpi, Radix Anemones Tomentosae mix, add water and do not have mixture to soak 50min, big fire is poured into after boiling 30min in marmite and is decocted 4h with little fire, stirs 5 times in process; Obtain extracting solution after filtration, flocculating agent chitosan is added sedimentation filtration in extracting solution and obtains cotton-shaped semi-finished product, for subsequent use; Chinese medicine flocculation separation technology produces cohesion by the absorption of flocculating agent, bridge formation, flocculation and inorganic salt electrolyte particulates and surface charge in Aqueous extracts flocculating agent being added to Chinese medicine, the microgranule of many instability such as protein, manganese liquid matter, natural gum, saddle matter etc. are made to connect into floc sedimentation sedimentation, through filtering the object reaching separation and purification.Use flocculating agent can retain effective ingredient largely, safety non-toxic, easy and simple to handle;

(3) moray and the bamboo rat seed oil of formula ratio is got, by the bamboo rat seed oil allotment of moray levigation, for subsequent use;

(4) semi-finished product mixing above-mentioned steps (1), (2), (3) obtained, add pregelatinized Starch, stearic acid, compound vitamin in mass ratio, after again Mirabilitum water being melted in the ratio of 1:5, add wherein, heat and stir into paste, sterilizing, cooling, packaging, makes liniment.

Embodiment 3: for the Chinese medicine composition of injury of sciatic nerve postoperative rehabilitation, component meter is made up of following raw material by weight: Tarenna mollissima (Hook. et Arn.) Robins. 65 parts, shamrock 60 parts, Bud root 56 parts, Canis familiaris L. ant grass 53 parts, Radix seu folium abelmoschi moschati 50 parts, tap grass 46 parts, Semen Sojae Preparatum 7 40 parts, white 35 parts, tripe, thorn tea Folium Mayteni hookeri 32 parts, the winter 30 parts, department, phlegmariurus hamictonii (Sprengel) Love et love varpeti-olaius (Clarke) Ching 27 parts, Cissus repens 25 parts, Herba saniculae orthacanthae 24 parts, Tibet chicken feet showy flowers of herbaceous plants 22 parts, Radix rubi Xanthocarpi 20 parts, bamboo rat seed oil 18 parts, Radix Anemones Tomentosae 10 parts, moray 8 parts.Also comprise following adjuvant: pregelatinized Starch 9 parts, magnesium stearate 8 parts, boric acid 5 parts, Mirabilitum 6 parts.Compound vitamin 0.049 part.

In described adjuvant, pregelatinized Starch is modified starch, mixes can make lubricant with magnesium stearate; Boric acid is external antibacterial, disinfectant and antiseptic, can suppress various bacteria, prevents medicament from going bad; Mirabilitum salty in the mouth, hardship, cold in nature, there is the effect of detumescence of relieving inflammation or internal heat.Described compound vitamin is vitamin B1, vitamin B6 and vitamin B12, its by weight component count: vitaminB10 .024 part, vitamin B6 0.012 part, vitamin B12 0.013 part.Vitamin B1, vitamin B6 and vitamin B12 can trophic nervees, improve nervous function, promote human metabolism, help the better absorption of medicine.

Preparation method for the externally applied liniment of the Chinese medicine composition of injury of sciatic nerve postoperative rehabilitation is:

(1) Tarenna mollissima (Hook. et Arn.) Robins. of formula ratio, shamrock, Semen Sojae Preparatum seven, thorn tea Folium Mayteni hookeri, phlegmariurus hamictonii (Sprengel) Love et love varpeti-olaius (Clarke) Ching fresh goods is got, smashed to pieces respectively and mixed, be placed in frying pan moderate heat to stir-fry the water added after 10min relative to mixture 15 times amount, big fire is boiled, change little fire decoction extraction filtration in 5 hours and obtain filtering residue and filtrate a, filtering residue enters juice extractor and squeezes and filter and obtain filtrate b, merging filtrate a and filtrate b, impurity is removed with resin adsorption method, heating is concentrated into pasty state, and after putting into the oven dry of 79 DEG C, baking oven, room temperature cools, grind to form fine powder, cross 200 mesh sieves;

(2) get the Bud root of formula ratio, Canis familiaris L. ant grass, Radix seu folium abelmoschi moschati, tap grass, white tripe, the winter department, Cissus repens, Herba saniculae orthacanthae, Tibet chicken feet showy flowers of herbaceous plants, Radix rubi Xanthocarpi, Radix Anemones Tomentosae mix, add water and do not have mixture to soak 60min, big fire is poured into after boiling 30min in marmite and is decocted 5h with little fire, stirs 6 times in process; Obtain extracting solution after filtration, flocculating agent chitosan is added sedimentation filtration in extracting solution and obtains cotton-shaped semi-finished product, for subsequent use; Chinese medicine flocculation separation technology produces cohesion by the absorption of flocculating agent, bridge formation, flocculation and inorganic salt electrolyte particulates and surface charge in Aqueous extracts flocculating agent being added to Chinese medicine, the microgranule of many instability such as protein, manganese liquid matter, natural gum, saddle matter etc. are made to connect into floc sedimentation sedimentation, through filtering the object reaching separation and purification.Use flocculating agent can retain effective ingredient largely, safety non-toxic, easy and simple to handle;

(3) moray and the bamboo rat seed oil of formula ratio is got, by the bamboo rat seed oil allotment of moray levigation, for subsequent use;

(4) semi-finished product mixing above-mentioned steps (1), (2), (3) obtained, add pregelatinized Starch, stearic acid, compound vitamin in mass ratio, after again Mirabilitum water being melted in the ratio of 1:5, add wherein, heat and stir into paste, sterilizing, cooling, packaging, makes liniment.

Clinical trial:

1. clinical case is selected

Choice criteria: choose that injury of sciatic nerve is postoperative occurs ulcer, limb rigidity, handicapped, there is patient 108 example of obvious pain, man 70 example, female 38 example, left side 57 example, right side 51 example.Be divided into 3 groups, often organize 36 people.

2. test method:

Affected part is applied to, every day three times with liniment prepared by the embodiment of the present invention 1 to first group.25 days courses for the treatment of, be used in conjunction 3 courses for the treatment of;

Be applied to affected part, every day three times to second group with liniment prepared by the embodiment of the present invention 2,22 days courses for the treatment of, be used in conjunction 3 courses for the treatment of;

Be applied to affected part, every day three times to the 3rd group with liniment prepared by the embodiment of the present invention 3,20 days courses for the treatment of, be used in conjunction 3 courses for the treatment of;

3. criterion of therapeutical effect and therapeutic outcome

3.1 criterion of therapeutical effect

(1) fully recover: ulcer symptoms disappears, pain disappears, disease sites functional rehabilitation, and activity freely, does not affect activity and work;

(2) effective: ulcer symptoms obviously improves, or is transferred to slightly by severe, and pain weakens, and patient's ability to act recovers substantially, does not affect work, only under strenuous exercise or tired situation, occurs mild;

(3) invalid: symptom without improvement, or has and increases the weight of trend.

3.2 treatment statistical results

Three groups of data merge statistics, recovery from illness: 80 examples, effectively: 25 examples, invalid: 3 examples.

4. conclusion: in clinical trial process, the patient accepting Drug therapy of the present invention finds no any untoward reaction, and the ulcer symptoms in various degree that patient occurs substantially all can be fully recovered, pain disappears, ability to act also can have clear improvement, and adheres to rehabilitation person's successful, recovers very fast.From data, the total effective rate of medicine of the present invention to injury of sciatic nerve postoperative rehabilitation reaches more than 97%, is the safe and effective medicine for injury of sciatic nerve postoperative rehabilitation, has good clinical meaning.

5. clinical individual case

Case 1: Wang, man, 37 years old, because traffic accident causes lower extremity injury, below thigh, lose sensation, after sending institute to treat, be diagnosed as injury of sciatic nerve, ulcer is there is after underwent operative treatment, shank pain, the symptom such as be slow in action, after a course for the treatment of treated by the liniment using the embodiment of the present invention 1 to prepare, pain disappears, ulcer symptoms disappears, and ability to act is clearly better, and fully recovers after three courses for the treatment of.Follow up a case by regular visits to after 6 months, do not recur.

Case 2: Xue woods, man, 50 years old, in work, buttocks was by knife injury, is diagnosed as injury of sciatic nerve after being admitted to hospital, after underwent operative treatment, carry out the postoperative rehabilitation of a period of time, but DeGrain, after a course for the treatment of treated by the liniment using the embodiment of the present invention 2 to prepare, symptom slows down, and is almost recovered after three courses for the treatment of.Follow up a case by regular visits to after 6 months, do not recur.

Case 3: Zhang, female, 29 years old, gluteus notes drug induced injury of sciatic nerve, and bone posterior muscular is paralysed, little leg outer side sensory deprivation, the symptom such as cause ulcer after carrying out operative treatment and be slow in action, after a course for the treatment of treated by the liniment using the embodiment of the present invention 3 to prepare, ulcer disappears, and after three courses for the treatment of, ability to act recovers.Follow up a case by regular visits to after 6 months, do not recur.

Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in previous embodiment, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of embodiment of the present invention technical scheme.

Claims (7)

1. for the Chinese medicine composition of injury of sciatic nerve postoperative rehabilitation, it is characterized in that component meter is made up of following raw material by weight: Tarenna mollissima (Hook. et Arn.) Robins. 45-65 part, shamrock 42-60 part, Bud root 38-56 part, Canis familiaris L. ant grass 35-53 part, Radix seu folium abelmoschi moschati 31-50 part, the careless 30-46 part of tap, Semen Sojae Preparatum seven 28-40 part, white tripe 20-35 part, thorn tea Folium Mayteni hookeri 18-32 part, winter department 17-30 part, phlegmariurus hamictonii (Sprengel) Love et love varpeti-olaius (Clarke) Ching 15-27 part, Cissus repens 13-25 part, Herba saniculae orthacanthae 12-24 part, Tibet chicken feet showy flowers of herbaceous plants 11-22 part, Radix rubi Xanthocarpi 10-20 part, bamboo rat seed oil 8-18 part, Radix Anemones Tomentosae 3-10 part, moray 2-8 part.

2., as claimed in claim 1 for the Chinese medicine composition of injury of sciatic nerve postoperative rehabilitation, it is characterized in that component meter is made up of following raw material by weight: Tarenna mollissima (Hook. et Arn.) Robins. 55 parts, shamrock 51 parts, Bud root 47 parts, Canis familiaris L. ant grass 44 parts, Radix seu folium abelmoschi moschati 40.5 parts, tap grass 38 parts, Semen Sojae Preparatum 7 34 parts, white 27.5 parts, tripe, thorn tea Folium Mayteni hookeri 25 parts, the winter 23.5 parts, department, phlegmariurus hamictonii (Sprengel) Love et love varpeti-olaius (Clarke) Ching 21 parts, Cissus repens 19 parts, Herba saniculae orthacanthae 18 parts, Tibet chicken feet showy flowers of herbaceous plants 16.5 parts, Radix rubi Xanthocarpi 15 parts, bamboo rat seed oil 13 parts, Radix Anemones Tomentosae 6.5 parts, moray 5 parts.

3., as claimed in claim 1 for the Chinese medicine composition of injury of sciatic nerve postoperative rehabilitation, characterized by further comprising following adjuvant: pregelatinized Starch 3-9 part, magnesium stearate 3-8 part, boric acid 2-5 part, Mirabilitum 1-6 part, compound vitamin 0.025-0.049 part.

4., as claimed in claim 3 for the Chinese medicine composition of injury of sciatic nerve postoperative rehabilitation, it is characterized in that, described adjuvant by weight component meter comprises: pregelatinized Starch 6 parts, magnesium stearate 5.5 parts, boric acid 3.5 parts, Mirabilitum 4.5 parts.Compound vitamin 0.037 part.

5., as claimed in claim 1 for the Chinese medicine composition of injury of sciatic nerve postoperative rehabilitation, it is characterized in that described Tarenna mollissima (Hook. et Arn.) Robins., shamrock, Semen Sojae Preparatum seven, thorn tea Folium Mayteni hookeri, phlegmariurus hamictonii (Sprengel) Love et love varpeti-olaius (Clarke) Ching are fresh goods.

6. the Chinese medicine composition for injury of sciatic nerve postoperative rehabilitation as described in claim 1 to 5 any one, is characterized in that the dosage form of described Chinese medicine composition is externally applied liniment.

7., as claimed in claim 6 for the preparation method of the Chinese medicine composition of injury of sciatic nerve postoperative rehabilitation, it is characterized in that comprising the following steps:

(1) Tarenna mollissima (Hook. et Arn.) Robins. of formula ratio, shamrock, Semen Sojae Preparatum seven, thorn tea Folium Mayteni hookeri, phlegmariurus hamictonii (Sprengel) Love et love varpeti-olaius (Clarke) Ching fresh goods is got, smashed to pieces respectively and mixed, stir-fry the water added after 10min relative to mixture 12 ~ 15 times amount, big fire is boiled, change little fire decoction extraction filtration in 3 ~ 5 hours and obtain filtering residue and filtrate a, filtering residue enters juice extractor and squeezes and filter and obtain filtrate b, merging filtrate a and filtrate b, impurity is removed with resin adsorption method, heating is concentrated into pasty state, after putting into the oven dry of 79 DEG C, baking oven, room temperature cools, and grinds to form fine powder;

(2) get the Bud root of formula ratio, Canis familiaris L. ant grass, Radix seu folium abelmoschi moschati, tap grass, white tripe, the winter department, Cissus repens, Herba saniculae orthacanthae, Tibet chicken feet showy flowers of herbaceous plants, Radix rubi Xanthocarpi, Radix Anemones Tomentosae mix, add water and do not have mixture to soak 40-60min, big fire is poured into after boiling 30min in marmite and is decocted 3-5h with little fire, stir 4-6 time in process, extracting solution is obtained after filtration, flocculating agent chitosan is added sedimentation filtration in extracting solution and obtains cotton-shaped semi-finished product, for subsequent use;

(3) moray and the bamboo rat seed oil of formula ratio is got, by the bamboo rat seed oil allotment of moray levigation, for subsequent use;

(4) semi-finished product mixing above-mentioned steps (1), (2), (3) obtained, add pregelatinized Starch, stearic acid, compound vitamin in mass ratio, after again Mirabilitum aquation being opened, add wherein, heat and stir into paste, sterilizing, cooling, packaging, makes liniment.