CN105194641A - External medicine for treating hyperplasia of mammary glands and preparation method thereof - Google Patents

Abstract

The invention discloses an external medicine for treating hyperplasia of mammary glands and a preparation method thereof, and aims to provide an external medicine, which is obvious in curative effect and small in side effect, for treating the hyperplasia of mammary glands and a preparation method thereof. The technical point is that the external medicine is mainly prepared from the following raw medicinal materials in parts by weight: 15-30 parts of black tea, 15-30 parts of ginger, 10-20 parts of Chinese angelica, 9-15 parts of desertliving cistanche, 9-15 parts of saffron, 8-12 parts of hawthorn fruit, 6-12 parts of suberect spatholobus stem, 6-12 parts of ginseng, 4-8 parts of cassia twig, 3-6 parts of scorpion, 20-30 parts of polyvinylpyrrolidone, 10-20 parts of ethyl alcohol, 1-2 parts of laurocapram, 1-3 parts of monoglyceride, 0.1-0.3 part of sodium methyl parahydroxybenzoate and 0.5-1 part of carbomer 2020. The external medicine belongs to the technical field of preparing traditional Chinese medicines.

Description

A kind of external used medicine for the treatment of cyclomastopathy and preparation method thereof

Technical field

The present invention discloses a kind of compositions, specifically, is a kind of external used medicine for the treatment of cyclomastopathy and preparation method thereof, belongs to Chinese drug preparation technique field.

Background technology

Cyclomastopathy refers to breast epithelium and proliferation of fibrous tissue, mammary gland tissue conduit and newborn lobule degeneration structurally and the growth of Progressive symmetric erythrokeratodermia connective tissue.Cyclomastopathy is the modal cystic hyperplasia of breast of women, and its sickness rate accounts for the first place of mastopathy.This sick sickness rate was in the trend risen year by year in the last few years, and the age also more and more becomes younger.About there is the women of 70% ~ 80% to have cyclomastopathy in various degree according to investigations, be more common in the women of 25 ~ 45 years old.

Its pathogenic factor mainly causes body constitution acidify because the dietary structure that people are long-term is unreasonable, living habit is bad, mental pressure is excessive etc., the function of human body declines, and then it is slack-off to cause body metabolism to circulate, this electrodeposition substance a large amount of cannot be discharged in vivo, cause QI and blood not smooth, the phenomenons such as endocrine hormone imbalance, menoxenia.

Traditional Chinese Medicine thinks that it is that Chinese medicine is referred to as " nodules of the breast " because depressed rage impairing the liver, worry impairing spleen, qi stagnation blood stasis, expectorant congeal into caused by core.

Modern medicine is then thought, its generation, develops and lapses to, and is because the hormonal circadian change in human female caused completely.When the estrogen level of ovarian secretion is too high, corpus luteum progestogen are very few, or both secretion is inharmonious, just can cause the breast ductal epithelial cells in breast and proliferation of fibrous tissue.Under normal circumstances, the acinus of the breast of each women adolesced, glandular tube and fibrous tissue, in each menstrual cycle, all will experience change in organization's process of hypertrophy and recovery.Due to this change, each women is premenstrual in the moon each time, and all likely occur the distending pain that one or both sides breast is light or heavy, distending pain Lock-out again after menstruation, this does not hinder life completely, study and work, is normal physiological phenomenon.But, when under the effect of body in some stressors (as work is too nervous, emotion is too exciting, advanced age is unmarried, not suckling in puerperal and suffer from some chronic disease etc.), the breast hyperplasia tissue just likely causing breast to restore can not get restoring or meromorphosis, in the course of time, just form cyclomastopathy, show as the newborn leaf and nodular particles that thicken, the three large sings and symptomses such as distending pain of the breast and nipple galactorrhea.

The external used medicine that market is used for the treatment of now mainly nodules of the breast paste, but there is following problems in this ointment: 1, this plaster be take package therapy skin ulceration and allergic phenomena of common occurrence; 2, be not easy to clean, easy pollution clothes; 3, high temperature oil plant explosive method has a strong impact on the composition of medicine, and effective composition meets with and destroys, likely lead poisoning; 4, be not easy hardening time to control, the shortcomings such as adhesion is poor, and mastic is excessive.

Summary of the invention

For the problems referred to above, the object of the present invention is to provide that a kind of therapeutic effect is good, medication external used medicine for the treatment of cyclomastopathy and preparation method thereof easily.

For achieving the above object, last technical scheme provided by the invention is such:

Treat an external used medicine for cyclomastopathy, be made up of the crude drug of following weight parts: black tea 15-30 part, Rhizoma Zingiberis Recens 15-30 part, Radix Angelicae Sinensis 10-20 part, Herba Cistanches 9-15 part, Stigma Croci 9-15 part, Fructus Crataegi 8-12 part, Caulis Spatholobi 6-12 part, Radix Ginseng 6-12 part, Ramulus Cinnamomi 4-8 part, Scorpio 3-6 part, polyvinylpyrrolidone 20-30 part, ethanol 10-20 part, lauryl azone 1-2 part, monoglyceride 1 part-3 parts, Sodium Methyl Hydroxybenzoate 0.1-0.3 part, 20200.5 parts-1 part, card ripple.

Further, the external used medicine of above-mentioned treatment cyclomastopathy, is made up of the crude drug of following weight parts: black tea 18-28 part, Rhizoma Zingiberis Recens 18-28 part, Radix Angelicae Sinensis 12-18 part, Herba Cistanches 11-13 part, Stigma Croci 11-13 part, Fructus Crataegi 9-11 part, Caulis Spatholobi 8-10 part, Radix Ginseng 8-10 part, Ramulus Cinnamomi 5-7 part, Scorpio 4-5 part, polyvinylpyrrolidone 22-28 part, ethanol 12-18 part, monoglyceride 1-3 part, lauryl azone 1-2 part, Sodium Methyl Hydroxybenzoate 0.1-0.3 part, 20200.5 parts-1 part, card ripple.

Further, the external used medicine of above-mentioned treatment cyclomastopathy, is made up of the crude drug of following weight parts: black tea 20-26 part, Rhizoma Zingiberis Recens 20-26 part, Radix Angelicae Sinensis 14-16 part, Herba Cistanches 9-11 part, Stigma Croci 9-11 part, Fructus Crataegi 7-9 part, Caulis Spatholobi 7-9 part, Radix Ginseng 7-9 part, Ramulus Cinnamomi 5-7 part, Scorpio 4-5 part, polyvinylpyrrolidone 24-26 part, ethanol 14-16 part, monoglyceride 1.5-2.5 part, lauryl azone 1-2 part, Sodium Methyl Hydroxybenzoate 0.1-0.3 part, 20200.5 parts-1 part, card ripple.

The preparation method of the external used medicine of the treatment cyclomastopathy that a rear technical scheme of the present invention is to provide, the method comprises the steps: successively

1) each component is taken;

2) to step 1) add 5-7 times of quality soak by water twice, each 30-60min in the crude drug that takes, filter and merge twice filtrate;

3) by filtrate at 65-80 DEG C of concentrating under reduced pressure, obtaining 20-30 DEG C of relative density is 1.03 ~ 1.05g/mL concentrated medicament;

4) add polyvinylpyrrolidone to concentrated medicament, ethanol, monoglyceride, lauryl azone, Sodium Methyl Hydroxybenzoate and Ka Bo 2020, then high-speed stirred 180 minutes in high speed scissors blender, to obtain final product.

Compared with prior art, the external used medicine for the treatment of cyclomastopathy provided by the invention, each component scientific compatibility, blood circulation promoting and blood stasis dispelling, dredges newborn network, dispersing swelling and dissipating binds, has obvious curative effects to cyclomastopathy, and have no side effect; Medicinal liquid can enter subcutaneous by the massage that only need take a morsel at the position of needs nursing during concrete use fast, improve the permeability of Skin Cell, chafe gland mouth increases, improve microcirculation and body blood hydromechanics and be easy to be penetrated absorption by medicine, disease is controlled, solve the untoward reaction of oral medicine, and the untoward reaction of external use plaster product and drawback.

Detailed description of the invention

Below in conjunction with detailed description of the invention, the present invention is described in further detail, but do not form any limitation of the invention, and the change of anyone limited number of time done within the scope of the claims in the present invention, still in claims of the present invention.

Embodiment 1

A kind of external used medicine for the treatment of cyclomastopathy provided by the invention, is made up of the crude drug of following weight: black tea 30g, Rhizoma Zingiberis Recens 15g, Radix Angelicae Sinensis 20g, Herba Cistanches 9g, Stigma Croci 15g, Fructus Crataegi 8g, Caulis Spatholobi 12g, Radix Ginseng 6g, Ramulus Cinnamomi 8g, Scorpio 6g, PVPK30 g, ethanol 20g, lauryl azone 1g, monoglyceride 3g, Sodium Methyl Hydroxybenzoate 0.1g, card ripple 20201g.

Embodiment 2

The external used medicine of another kind treatment cyclomastopathy provided by the invention, is made up of the crude drug of following weight: black tea 15g, Rhizoma Zingiberis Recens 30g, Radix Angelicae Sinensis 10g, Herba Cistanches 15g, Stigma Croci 9g, Fructus Crataegi 12g, Caulis Spatholobi 6g, Radix Ginseng 2g, Ramulus Cinnamomi 4g, Scorpio 3g, polyvinylpyrrolidone 20g, ethanol 20g, lauryl azone 1g, monoglyceride 3g, Sodium Methyl Hydroxybenzoate 0.1g, card ripple 20201g.

Embodiment 3

The external used medicine of another kind treatment cyclomastopathy provided by the invention, is made up of the crude drug of following weight: black tea 18g, Rhizoma Zingiberis Recens 28g, Radix Angelicae Sinensis 18g, Herba Cistanches 11g, Stigma Croci 13g, Fructus Crataegi 9g, Caulis Spatholobi 10g, Radix Ginseng 8g, Ramulus Cinnamomi 7g, Scorpio 5g, polyvinylpyrrolidone 28g, ethanol 12g, monoglyceride 3g, lauryl azone 1g, Sodium Methyl Hydroxybenzoate 0.3g, card ripple 20200.5g.

Embodiment 4

The external used medicine of another kind treatment cyclomastopathy provided by the invention, is made up of the crude drug of following weight: black tea 18g, Rhizoma Zingiberis Recens 28g, Radix Angelicae Sinensis 12g, Herba Cistanches 13g, Stigma Croci 11g, Fructus Crataegi 11g, Caulis Spatholobi 8g, Radix Ginseng 10g, Ramulus Cinnamomi 5g, Scorpio 4g, polyvinylpyrrolidone 22g, ethanol 18g, monoglyceride 1g, lauryl azone 2g, Sodium Methyl Hydroxybenzoate 0.1g, card ripple 20201g.

Embodiment 5

The external used medicine of another kind treatment cyclomastopathy provided by the invention, is made up of the crude drug of following weight: black tea 25g, Rhizoma Zingiberis Recens 25g, Radix Angelicae Sinensis 15g, Herba Cistanches 10g, Stigma Croci 10g, Fructus Crataegi 8g, Caulis Spatholobi 8g, Radix Ginseng 8g, Ramulus Cinnamomi 6g, Scorpio 5g, polyvinylpyrrolidone 25g, ethanol 15g, monoglyceride 2g, lauryl azone 1.5g, Sodium Methyl Hydroxybenzoate 0.2g, card ripple 20200.8g.

In embodiment 1 to 5, the preparation method of the external used medicine of any one treatment cyclomastopathy, comprises the steps: successively

1) each component is taken by one group of weight portion any in embodiment 1 to 5;

2) to step 1) add 5-7 times of quality soak by water twice, each 30-60min in the crude drug that takes, filter and merge twice filtrate;

3) obtaining 20-30 DEG C of relative density at 65-80 DEG C of concentrating under reduced pressure is 1.03 ~ 1.05g/mL concentrated medicament;

4) add polyvinylpyrrolidone to concentrated medicament, ethanol, monoglyceride, lauryl azone, Sodium Methyl Hydroxybenzoate and Ka Bo 2020, then high-speed stirred 180 minutes in high speed scissors blender, to obtain final product.

During use, this product massage that only need take a morsel at the position of needs use absorbs.

In order to advantage of the present invention is better described, provide the experiment case of technical scheme provided by the invention below:

Case 1

Wang, female, 42 years old, primary symptom bilateral breast pain 3 years, the outside upper quadrant of bilateral breast can touch lamellar enclosed mass, matter is hard, and bilateral breast cyclomastopathy, smears medicine for external use provided by the invention three months, medication every month 7 days, once distending pain of the breast disappeared, and discontinues medication, without recurrence each morning and evening.

Case 2

Chen, female, 38 years old, mammary gland pain 1 year on the left of primary symptom, the outside upper quadrant of right mammary gland can touch lamellar enclosed mass, and matter is hard, and bilateral breast cyclomastopathy, smears medicine for external use provided by the invention 14 days, and each sooner or later once distending pain of the breast disappears, and discontinues medication, without recurrence.

Case 3

Liu, female, 33 years old, primary symptom right side breast pain 1 year, mammary gland outside upper quadrant in left side can touch lamellar enclosed mass, matter is hard, and cyclomastopathy, smears medicine for external use provided by the invention two months, medication every month 7 days, once distending pain of the breast disappeared, and discontinues medication, without recurrence each morning and evening.

Claims (4)

1. treat an external used medicine for cyclomastopathy, it is characterized in that, be made up of the crude drug of following weight parts: black tea 15-30 part, Rhizoma Zingiberis Recens 15-30 part, Radix Angelicae Sinensis 10-20 part, Herba Cistanches 9-15 part, Stigma Croci 9-15 part, Fructus Crataegi 8-12 part, Caulis Spatholobi 6-12 part, Radix Ginseng 6-12 part, Ramulus Cinnamomi 4-8 part, Scorpio 3-6 part, polyvinylpyrrolidone 20-30 part, ethanol 10-20 part, lauryl azone 1-2 part, monoglyceride 1-3 part, Sodium Methyl Hydroxybenzoate 0.1-0.3 part, 20200.5 parts-1 part, card ripple.

2. the external used medicine for the treatment of cyclomastopathy according to claim 1, it is characterized in that, be made up of the crude drug of following weight parts: black tea 18-28 part, Rhizoma Zingiberis Recens 18-28 part, Radix Angelicae Sinensis 12-18 part, Herba Cistanches 11-13 part, Stigma Croci 11-13 part, Fructus Crataegi 9-11 part, Caulis Spatholobi 8-10 part, Radix Ginseng 8-10 part, Ramulus Cinnamomi 5-7 part, Scorpio 4-5 part, polyvinylpyrrolidone 22-28 part, ethanol 12-18 part, monoglyceride 1-3 part, lauryl azone 1-2 part, Sodium Methyl Hydroxybenzoate 0.1-0.3 part, 20200.5 parts-1 part, card ripple.

3. the external used medicine for the treatment of cyclomastopathy according to claim 1 and 2, it is characterized in that, be made up of the crude drug of following weight parts: black tea 20-26 part, Rhizoma Zingiberis Recens 20-26 part, Radix Angelicae Sinensis 14-16 part, Herba Cistanches 9-11 part, Stigma Croci 9-11 part, Fructus Crataegi 7-9 part, Caulis Spatholobi 7-9 part, Radix Ginseng 7-9 part, Ramulus Cinnamomi 5-7 part, Scorpio 4-5 part, polyvinylpyrrolidone 24-26 part, ethanol 14-16 part, monoglyceride 1.5-2.5 part, lauryl azone 1-2 part, Sodium Methyl Hydroxybenzoate 0.1-0.3 part, 20200.5 parts-1 part, card ripple.

4. the preparation method of the external used medicine for the treatment of cyclomastopathy according to claim 1, comprises the steps: successively

1) each component is taken by mass parts according to claim 1;

2) to step 1) add 5-7 times of quality soak by water twice, each 30-60min in the crude drug that takes, filter and merge twice filtrate;

3) by filtrate at 65-80 DEG C of concentrating under reduced pressure, obtaining 20-30 DEG C of relative density is 1.03 ~ 1.05g/mL concentrated medicament;

4) add polyvinylpyrrolidone to concentrated medicament, ethanol, monoglyceride, lauryl azone, Sodium Methyl Hydroxybenzoate and Ka Bo 2020, then high-speed stirred 180 minutes in high speed scissors blender, to obtain final product.