CN105214064A - External used medicine for the treatment of cyclomastopathy and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of external used medicine for the treatment of cyclomastopathy and preparation method thereof; Aim to provide the external used medicine that a kind of therapeutic effect is good, cyclomastopathy is treated in medication easily; Its technical essential is: the external used medicine of this treatment cyclomastopathy, and the crude drug primarily of following weight parts is made: black tea 10-20 part, Rhizoma Zingiberis Recens 10-20 part, Flos Albiziae 8-12 part, Flos Carthami 8-12 part, Cortex Moutan 6-10 part, Natrii Sulfas 5-10 part, Myrrha 5-10 part, Ramulus Cinnamomi 4-8 part, Radix Angelicae Sinensis 4-8 part, Retinervus Luffae Fructus 3-6 part, polyvinylpyrrolidone 20-30 part, ethanol 10-20 part, lauryl azone 1-2 part, monoglyceride 1-3 part, Sodium Methyl Hydroxybenzoate 0.1-0.3 part, card ripple 2020? 0.5 part-1 part; Belong to Chinese drug preparation technique field.

Description

External used medicine for the treatment of cyclomastopathy and preparation method thereof

Technical field

The present invention discloses a kind of medicine for the treatment of cyclomastopathy, specifically, is a kind of external used medicine for the treatment of cyclomastopathy, belongs to Chinese drug preparation technique field.

Background technology

Cyclomastopathy refers to breast epithelium and proliferation of fibrous tissue, mammary gland tissue conduit and newborn lobule degeneration structurally and the growth of Progressive symmetric erythrokeratodermia connective tissue.Cyclomastopathy is the modal cystic hyperplasia of breast of women, and its sickness rate accounts for the first place of mastopathy.This sick sickness rate was in the trend risen year by year in the last few years, and the age also more and more becomes younger.About there is the women of 70% ~ 80% to have cyclomastopathy in various degree according to investigations, be more common in the women of 25 ~ 45 years old.

Its pathogenic factor mainly causes body constitution acidify because the dietary structure that people are long-term is unreasonable, living habit is bad, mental pressure is excessive etc., the function of human body declines, and then it is slack-off to cause body metabolism to circulate, this electrodeposition substance a large amount of cannot be discharged in vivo, cause QI and blood not smooth, the phenomenons such as endocrine hormone imbalance, menoxenia.

Traditional Chinese Medicine thinks that it is that Chinese medicine is referred to as nodules of the breast because depressed rage impairing the liver, worry impairing spleen, qi stagnation blood stasis, expectorant congeal into caused by core.

Modern medicine is then thought, its generation, develops and lapses to, and is because the hormonal circadian change in human female caused completely.When the estrogen level of ovarian secretion is too high, corpus luteum progestogen are very few, or both secretion is inharmonious, just can cause the breast ductal epithelial cells in breast and proliferation of fibrous tissue.Under normal circumstances, the acinus of the breast of each women adolesced, glandular tube and fibrous tissue, in each menstrual cycle, all will experience change in organization's process of hypertrophy and recovery.Due to this change, each women is premenstrual in the moon each time, and all likely occur the distending pain that one or both sides breast is light or heavy, distending pain Lock-out again after menstruation, this does not hinder life completely, study and work, is normal physiological phenomenon.But, when under the effect of body in some stressors (as work is too nervous, emotion is too exciting, advanced age is unmarried, not suckling in puerperal and suffer from some chronic disease etc.), the breast hyperplasia tissue just likely causing breast to restore can not get restoring or meromorphosis, in the course of time, just form cyclomastopathy, show as the newborn leaf and nodular particles that thicken, the three large sings and symptomses such as distending pain of the breast and nipple galactorrhea.

The external used medicine that market is used for the treatment of now mainly nodules of the breast paste, but there is following problems in this ointment: 1, this plaster be take package therapy skin ulceration and allergic phenomena of common occurrence; 2, be not easy to clean, easy pollution clothes; 3, high temperature oil plant explosive method has a strong impact on the composition of medicine, and effective composition meets with and destroys, likely lead poisoning; 4, be not easy hardening time to control, the shortcomings such as adhesion is poor, and mastic is excessive.

Summary of the invention

For the problems referred to above, the object of this invention is to provide the external used medicine that a kind of therapeutic effect is good, cyclomastopathy is treated in medication easily.

For achieving the above object, last technical scheme of the present invention is such:

The external used medicine of this treatment cyclomastopathy, the crude drug primarily of following weight parts is made: black tea 10-20 part, Rhizoma Zingiberis Recens 10-20 part, Flos Albiziae 8-12 part, Flos Carthami 8-12 part, Cortex Moutan 6-10 part, Natrii Sulfas 5-10 part, Myrrha 5-10 part, Ramulus Cinnamomi 4-8 part, Radix Angelicae Sinensis 4-8 part, Retinervus Luffae Fructus 3-6 part, polyvinylpyrrolidone 20-30 part, ethanol 10-20 part, monoglyceride 1-3 part, lauryl azone 1-2 part, Sodium Methyl Hydroxybenzoate 0.1-0.3 part, 20200.5 parts-1 part, card ripple.

Further, the external used medicine of above-mentioned treatment cyclomastopathy, the raw material primarily of following weight parts is made: black tea 12-18 part, Rhizoma Zingiberis Recens 12-18 part, Flos Albiziae 9-11 part, Flos Carthami 9-11 part, Cortex Moutan 7-9 part, Natrii Sulfas 7-9 part, Myrrha 7-9 part, Ramulus Cinnamomi 5-7 part, Radix Angelicae Sinensis 5-7 part, Retinervus Luffae Fructus 4-5 part, polyvinylpyrrolidone 22-28 part, ethanol 12-18 part, monoglyceride 1-3 part, lauryl azone 1-2 part, Sodium Methyl Hydroxybenzoate 0.1-0.3 part, 20200.5 parts-1 part, card ripple.

After of the present invention, a technical scheme is such: comprise the steps: successively

1) each crude drug is taken;

2) to step 1) black tea that takes, Rhizoma Zingiberis Recens, Radix Angelicae Sinensis, Flos Albiziae, Flos Carthami, Cortex Moutan, Myrrha, Ramulus Cinnamomi, Retinervus Luffae Fructus, adds medical material gross weight 5-7 times soak by water twice, each 30-60min, collects and filters and merge twice filtrate;

3) in filtrate, add Natrii Sulfas, obtaining 20-30 DEG C of relative density at 65-80 DEG C of concentrating under reduced pressure is 1.03 ~ 1.05g/mL concentrated medicament;

4) add polyvinylpyrrolidone to concentrated medicament, ethanol, monoglyceride, lauryl azone, Sodium Methyl Hydroxybenzoate and Ka Bo 2020, then high-speed stirred 180 minutes in high speed scissors blender, to obtain final product.

Compared with prior art, the external used medicine for the treatment of cyclomastopathy provided by the invention, each component scientific compatibility, blood circulation promoting and blood stasis dispelling, dredges newborn network, dispersing swelling and dissipating binds, has obvious curative effects to cyclomastopathy, have no side effect; Medicinal liquid can enter subcutaneous by the massage that only need take a morsel at the position of needs nursing during concrete use fast, improve the permeability of Skin Cell, chafe gland mouth increases, improve microcirculation and body blood hydromechanics and be easy to be penetrated absorption by medicine, disease is controlled, solve the untoward reaction of oral medicine, and the untoward reaction of external use plaster product and drawback.

Detailed description of the invention

Below in conjunction with detailed description of the invention, the present invention is described in further detail, but do not form any limitation of the invention, and the change of anyone limited number of time done within the scope of the claims in the present invention, still in claims of the present invention.

Embodiment 1

A kind of external used medicine for the treatment of cyclomastopathy provided by the invention, the crude drug primarily of following weight is made: black tea 20g, Rhizoma Zingiberis Recens 10g, Flos Albiziae 8g, Flos Carthami 12g, Cortex Moutan 6g, Natrii Sulfas 10g, Myrrha 5g, Ramulus Cinnamomi 8g, Radix Angelicae Sinensis 4g, Retinervus Luffae Fructus 6g, polyvinylpyrrolidone 20g, ethanol 20g, lauryl azone 1g, monoglyceride 3g, Sodium Methyl Hydroxybenzoate 0.1g, card ripple 20201g.

Embodiment 2

A kind of external used medicine for the treatment of cyclomastopathy provided by the invention, the crude drug primarily of following weight is made: black tea 10g, Rhizoma Zingiberis Recens 20g, Flos Albiziae 12g, Flos Carthami 8g, Cortex Moutan 10g, Natrii Sulfas 5g, Myrrha 10g, Ramulus Cinnamomi 4g, Radix Angelicae Sinensis 8g, Retinervus Luffae Fructus 3g, PVPK30 g, ethanol 10g, lauryl azone 2g, monoglyceride 1g, Sodium Methyl Hydroxybenzoate 0.3g, card ripple 20200.5g.

Embodiment 3

A kind of external used medicine for the treatment of cyclomastopathy provided by the invention, the crude drug primarily of following weight is made: black tea 18g, Rhizoma Zingiberis Recens 12g, Flos Albiziae 11g, Flos Carthami 9g, Cortex Moutan 9g, Natrii Sulfas 7g, Myrrha 9g, Ramulus Cinnamomi 5g, Radix Angelicae Sinensis 7g, Retinervus Luffae Fructus 4g, polyvinylpyrrolidone 22g, ethanol 18g, monoglyceride 1g, lauryl azone 2g, Sodium Methyl Hydroxybenzoate 0.1g, card ripple 20201g.

Embodiment 4

A kind of external used medicine for the treatment of cyclomastopathy provided by the invention, the crude drug primarily of following weight is made: black tea 15g, Rhizoma Zingiberis Recens 15g, Flos Albiziae 10g, Flos Carthami 10g, Cortex Moutan 8g, Natrii Sulfas 8g, Myrrha 8g, Ramulus Cinnamomi 6g, Radix Angelicae Sinensis 6g, Retinervus Luffae Fructus 4g, polyvinylpyrrolidone 25g, ethanol 15g, monoglyceride 2g, lauryl azone 2g, Sodium Methyl Hydroxybenzoate 0.2g, card ripple 20200.8g.

Implement the preparation method for the treatment of the external used medicine of cyclomastopathy in 1 to 4,

1) each raw material is taken by one group of weight portion any in enforcement 1 to 4;

2) by step 1) black tea that takes, Rhizoma Zingiberis Recens, Flos Albiziae, Flos Carthami, Cortex Moutan, Myrrha, Ramulus Cinnamomi, Radix Angelicae Sinensis, Retinervus Luffae Fructus adds medical material gross weight 5-7 times soak by water twice, each 30-60min, collects and filters and merge twice filtrate;

3) in filtrate, add Natrii Sulfas, obtaining 20-30 DEG C of relative density at 65-80 DEG C of concentrating under reduced pressure is 1.03 ~ 1.05g/mL concentrated medicament;

4) add polyvinylpyrrolidone to concentrated medicament, ethanol, monoglyceride, lauryl azone, Sodium Methyl Hydroxybenzoate and Ka Bo 2020, then high-speed stirred 180 minutes in high speed scissors blender, to obtain final product.

During use, this product massage that only need take a morsel at the position of needs use absorbs.

In order to advantage of the present invention is better described, provide the experiment case of technical scheme provided by the invention below:

Case 1

Wang, female, 28 years old, primary symptom bilateral breast pain half a year, the outside upper quadrant of bilateral breast can touch lamellar enclosed mass, and matter is hard, and bilateral breast cyclomastopathy, smears medicine for external use provided by the invention 7 days, each sooner or later once, distending pain of the breast disappears.

Case 2

Zhang, female, 40 years old, mammary gland pain 1 year on the left of primary symptom, the outside upper quadrant of bilateral breast can touch lamellar enclosed mass, and matter is hard, and bilateral breast cyclomastopathy, smears medicine for external use provided by the invention 14 days, and each morning and evening, once distending pain of the breast disappeared.

Case 3

Liu, female, 30 years old, mammary gland pain 1 year on the left of primary symptom, mammary gland outside upper quadrant in left side can touch lamellar enclosed mass, and matter is hard, and cyclomastopathy, smears medicine for external use provided by the invention 14 days, and each morning and evening, once distending pain of the breast disappeared.

Claims (3)

1. treat an external used medicine for cyclomastopathy, it is characterized in that, the crude drug primarily of following weight parts is made: black tea 10-20 part, Rhizoma Zingiberis Recens 10-20 part, Flos Albiziae 8-12 part, Flos Carthami 8-12 part, Cortex Moutan 6-10 part, Natrii Sulfas 5-10 part, Myrrha 5-10 part, Ramulus Cinnamomi 4-8 part, Radix Angelicae Sinensis 4-8 part, Retinervus Luffae Fructus 3-6 part, polyvinylpyrrolidone 20-30 part, ethanol 10-20 part, lauryl azone 1-2 part, monoglyceride 1-3 part, Sodium Methyl Hydroxybenzoate 0.1-0.3 part, 20200.5 parts-1 part, card ripple.

2. the external used medicine for the treatment of cyclomastopathy according to claim 1, it is characterized in that, crude drug primarily of following weight parts is made: black tea 12-18 part, Rhizoma Zingiberis Recens 12-18 part, Flos Albiziae 9-11 part, Flos Carthami 9-11 part, Cortex Moutan 7-9 part, Natrii Sulfas 7-9 part, Myrrha 7-9 part, Ramulus Cinnamomi 5-7 part, Radix Angelicae Sinensis 5-7 part, Retinervus Luffae Fructus 4-5 part, polyvinylpyrrolidone 22 parts-28 parts, ethanol 12-18 part, lauryl azone 1-2 part, monoglyceride 1-3 part, Sodium Methyl Hydroxybenzoate 0.1-0.3 part, 20200.5 parts-1 part, card ripple.

3. the external used medicine preparation method for the treatment of cyclomastopathy according to claim 1, is characterized in that, comprise the steps: successively

1) each raw material is taken by weight portion according to claim 1;

2) by step 1) black tea that takes, Rhizoma Zingiberis Recens, Radix Angelicae Sinensis, Flos Albiziae, Flos Carthami, Cortex Moutan, Myrrha, Ramulus Cinnamomi, Retinervus Luffae Fructus adds medical material gross weight 5-7 times soak by water twice, each 30-60min, collects and filters and merge twice filtrate;

3) in filtrate, add Natrii Sulfas, obtaining 20-30 DEG C of relative density at 65-80 DEG C of concentrating under reduced pressure is 1.03 ~ 1.05g/mL concentrated medicament;

4) add polyvinylpyrrolidone to concentrated medicament, ethanol, monoglyceride, lauryl azone, Sodium Methyl Hydroxybenzoate and Ka Bo 2020, then high-speed stirred 180 minutes in high speed scissors blender, to obtain final product.