CN105194511A - Medicine composition for functional uterine hemorrhage and postpartum hemorrhage - Google Patents

Abstract

The invention relates to a medicine composition for functional uterine hemorrhage and postpartum hemorrhage. A preparation method of the medicine composition comprises the following steps: taking 1000 g of clinopodium polycephalum, chopping, adding water for 1.5 hours' decocting twice, merging decoctions, filtering, concentrating to obtain a concentrate I of 1.15 g/ml, adding ethanol of which the weight is 1.7 times of that of the concentrate I, fully stirring, performing still standing for 24 h, taking an supernatant, conducting vacuum concentration to obtain a concentrate II 1.1 g/ml, adding water of which the weight is double of that of the concentrate II, fully stirring, performing still standing for 24 h, filtering, adding 290 ml of simple syrup and 2.5 g of sodium benzoate, adding water until 1000 ml, and conducting stirring, filling and sterilization to obtain the medicine composition. The prepared medicine composition is low in cost and wide in application prospect.

Description

For the pharmaceutical composition of dysfunctional uterine hemorrhage and postpartum hemorrhage

Technical field

The invention belongs to Chinese medicine technical field, concrete, relate to a kind of pharmaceutical composition for dysfunctional uterine hemorrhage and postpartum hemorrhage.

Background technology

Dysfunctional uterine hemorrhage is also called palace blood, is to cause by by neuroendocrine disorders, instead of is caused by gestation, endometrial tumors, infection or hematopathy etc.Often betide adolescence, be anovulatory dysfunctional metrorrhagia, also known as pubertal dysfunctional uterine bleeding, cause the reason of anovulatory functional bleeding, different with climacteric in adolescence, Adolescent Dysfunctional is many reaches maturity incomplete due to hypothalamic-pituitary-ovarian axis or postpones, perfect positive feedback regulatory mechanism is not yet set up between hypothalamus body and ovary, under the effect of hypophysis follicle stimulating hormone (FSH) and lutropin (LH), follicular development secretion estrogen, but oestrogens on hypothalamic positive feedback not yet should can form FSH and LH peak in normal menstrual cycle, though thus have follicular development in ovary but can not ovulate, Menopause DUB is mainly due to ovarian function dieback, follicle quantity reduces but can not reach maturity, pituitary gonadotropic hormone reaction is reduced simultaneously, thus when ovarian failure, ovulation stops and causing climacteric androgen-induced sterile rats.

Based on hormonal medicaments, progestogen, estrogen and androgen to be divided at present for the drug main stopped blooding.When adopting progestogen to stop blooding, supplementary progestogen can make the endometrial transformation being in proliferative phase or Swiss cheese hyperplasia be the secretory phase, and after drug withdrawal, inner membrance comes off, and occur Withdrawal hemorrhage.Because this kind of inner membrance comes off comparatively thorough, therefore also known as " medical curettage ".Be applicable to the existing estrogenic patient of certain level in body.Adopt estrogen when stopping blooding, apply heavy dose of estrogen and can improve rapidly blood inner estrogen concentration, impel endometrial growth, in a short time wound repairing and stopping blooding.Be applicable to endogenous estrogen deficiency person, be mainly used in Adolescent Dysfunctional.Current multiselect conjugated estrogens also can use diethylstilbestrol, and the shortcoming of oral diethylstilbestrol is gastrointestinal reaction weight, and drug absorption is slow, not easily proves effective rapidly, if desired can oral conjugated estrogens or benzoic acid, estradiol intramuscular injection.To reach quick-acting haemostatic powder.Application androgen is when stopping blooding, and during massive hemorrhage, androgen can not change inner membrance immediately and to come off process, and it can not be made to repair rapidly, and independent effect is not good.Because the haemostatic effect of gonadal hormone drug combination is better than single medicine, therefore when clinical practice, often adopt above three parahormones carry out selection compatibility two kinds or use, good effect can be played.But the familiar lacunas of hormone medicine is obvious, often can not drug withdrawal at once, need slowly decrement until stop using, also easily Withdrawal bleeding to occur simultaneously.

Dysfunctional uterine hemorrhage belongs to the categories such as the traditional Chinese medical science " metrorrhagia ", polyphyly insufficiency of vital energy and blood, and the impairment of chong and ren channels, can not restrict menses, therefore absurd row when menses are non-from uterus.In dirty duty in suffering from a deficiency of the kidney, again with insufficiency of the spleen or stagnation of liver-QI is relevant, mainly relevant with the deficiency of vital energy, blood stasis, heat in blood in QI and blood.Have in "Fu Qingzhu works on obstetric" " going out all kidneys through water ", " chong channel is too warm and namely blood boil, the disease of metrorrhagia, chong channel be disease, chong channel too also hot ".Chinese traditional treatment dysfunctional uterine hemorrhage will according to the Symptoms of patient, and the Characteristics of Syndromes of the state of an illness takes corresponding Therapeutic Method, and outstanding determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, often can receive comparatively satisfied curative effect.Be summed up, the main method for the treatment of of Chinese traditional treatment dysfunctional uterine hemorrhage has: 1. heat in blood Phlegm-Heat Internal confusion Type: control suitable clearing away heat and cooling blood, regulating menstruation, hemostasis; 2. type of stagnation of blood stasis: control suitable blood circulation promoting and blood stasis dispelling, nourishing blood for regulating menstruation method; 3. kidney yang deficiency: control suitable warming and recuperating the kidney-YANG, QI invigorating Gu Chong; 4. kidney-yin deficiency type: control suitable kidney tonifying YIN nourishing, cooling blood for hemostasis.

Prior art prescriptions of Chinese medicine lacks dialectical, and treatment cycle is long, and suiting the medicine to the illness property is not strong, and curative effect is not obvious, even also can bring side effect to patient, increases patient suffering.

Summary of the invention

The object of this invention is to provide a kind for the treatment of both the principal and secondary aspects of a disease, have no side effect, safe ready, cheap pure traditional Chinese compound medicine.

Object of the present invention is exactly to solve problems of the prior art, thering is provided a kind of is that the QI invigorating that has of main component holds up unit with Chinese medicine, the effect of cooling blood and removing stasis, blood-arresting catamenia-regulating, has the Chinese medicine composition of Be very effective to treatment dysfunctional uterine hemorrhage and postpartum hemorrhage.Present inventor puts into practice according to doctor's row for many years in conjunction with forefathers' secret recipe, by the research to Chinese medicine, and in conjunction with dialectical demonstration, in many ways the length of many families is collected, seek therapeutic regimen, from motherland's medical treasure-house, filter out benefiting QI and nourishing blood, to invigorate blood circulation the natural Chinese medicine of blood stasis expelling, by theory of Chinese medical science prescription, skim the cream off milk, the Fuke Zhixueling capsule for dysfunctional uterine hemorrhage of the present invention is meticulously mixed with in conjunction with Traditional Chinese Medicine technology, it is rapid-action, effect is strong, short treating period, safety is high, without obvious toxic-side effects, medication is simple, treatment blood deficiency, heat in blood, the metrorrhagia of blood stasis, disappearing of endometrial renewal and inflammation is contributed to for postpartum hemorrhage symptom, also can make the Placenta Hominis in utero remained, fetal membrane is discharged automatically, remove the uterine cavity stasis of blood to amass.

For achieving the above object, the technical solution used in the present invention is as follows:

For the pharmaceutical composition of dysfunctional uterine hemorrhage and postpartum hemorrhage, it is prepared from by following method:

Get Herba Clinopodii 1000g, cutting, decoct with water secondary, each 1.5 hours, collecting decoction, filters, is concentrated into 1.15g/ml, add 1.7 times of w ethanol (70% refers to volume ratio herein), fully stir, leave standstill 24h, get supernatant and be evaporated to 1.1g/ml, add 1 times of weight water, fully stir, leave standstill 24h, filter, add simple syrup 290ml, sodium benzoate 2.5g, adds water to 1000ml, stirs fill sterilizing and get final product.

In literary composition, relative density is the relative density of 80 DEG C.

Preferably, for the pharmaceutical composition of dysfunctional uterine hemorrhage and postpartum hemorrhage, it is prepared from by following method:

Get Herba Clinopodii 800g, cutting, decoct with water secondary, each 1.5 hours, collecting decoction, filters, is concentrated into 1.15g/ml, adds 1.7 times of w ethanol (70% refers to volume ratio herein), abundant stirring, leaves standstill 24h, gets supernatant and be evaporated to 1.1g/ml, add 1 times of weight water, fully stir, leave standstill 24h, filter, add the effective ingredient 200ml that enriches blood, simple syrup 240ml, sodium benzoate 2.5g, adds water to 1000ml, stirs fill sterilizing and get final product.

Described effective ingredient of enriching blood, it is prepared by the raw material of following weight parts and obtains:

Cacumen Platycladi 20 parts, the Flos Sophorae Immaturus 20 parts, Rhizoma Imperatae 20 parts, Radix Cirsii Japonici 15 parts, Radix Angelicae Sinensis 15 parts,

Fructus Schisandrae Chinensis 12 parts, Herba Taraxaci 12 parts, Fructus Forsythiae 12 parts, Fructus Tsaoko 10 parts, 10 parts, Fructus Mori,

Spina Gleditsiae 10 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 parts, Semen Coicis 8 parts, 5 parts, Radix Glycyrrhizae, Pericarpium Citri Reticulatae 5 parts, Rhizoma Dioscoreae 5 parts.

The preparation method of described effective ingredient of enriching blood is as follows:

Take above-mentioned raw materials according to parts by weight, add 2 times of weight 70% alcohol reflux twice, each 1-2 hour, merge extractive liquid, filter, be evaporated to 1.1g/ml, then add 1 times of weight water, fully stir, leave standstill 24h, filter, to obtain final product.

The component of medicine of the present invention all adopts natural raw material of Chinese medicine, its preparation is easy, medicine source is extensive, and with low cost, it follows the prescriptions principle of the traditional Chinese medical science, there is QI invigorating and hold up unit, the effect of cooling blood and removing stasis, blood-arresting catamenia-regulating, can play fine therapeutical effect to dysfunctional uterine hemorrhage, has good effect, the cycle is short, price is low, without any untoward reaction, patient medication is convenient, economical, can continuously, long-term prescription and be unlikely to the toxic and side effects of generation to the organ injury such as liver and kidney; Having good effect to dysfunctional uterine hemorrhage, is a kind of active drug preventing and treating dysfunctional uterine hemorrhage that patient takes like a shot.Through clinical practice checking, it is reliably evident in efficacy, mild in medicine property and, there is not toxic and side effects, have a extensive future.

Detailed description of the invention

Embodiment 1

For the pharmaceutical composition of dysfunctional uterine hemorrhage and postpartum hemorrhage, it is prepared from by following method:

Get Herba Clinopodii 1000g, cutting, add 2 times of soak by water secondaries, each 1.5 hours, collecting decoction, filters, is concentrated into 1.15g/ml, add 1.7 times of w ethanol (70% refers to volume ratio herein), fully stir, leave standstill 24h, get supernatant and be evaporated to 1.1g/ml, add 1 times of weight water, fully stir, leave standstill 24h, filter, add simple syrup 290ml, sodium benzoate 2.5g, adds water to 1000ml, stirs fill sterilizing and get final product.

In literary composition, relative density is the relative density of 80 DEG C.

Usage and dosage, oral, a 10ml, three times on the one.

Embodiment 2

For the pharmaceutical composition of dysfunctional uterine hemorrhage and postpartum hemorrhage, it is prepared from by following method:

Get Herba Clinopodii 800g, cutting, add 2 times of soak by water secondaries, each 1.5 hours, collecting decoction, filters, is concentrated into 1.15g/ml, adds 1.7 times of w ethanol (70% refers to volume ratio herein), abundant stirring, leaves standstill 24h, gets supernatant and be evaporated to 1.1g/ml, add 1 times of weight water, fully stir, leave standstill 24h, filter, add the effective ingredient 200ml that enriches blood, simple syrup 240ml, sodium benzoate 2.5g, adds water to 1000ml, stirs fill sterilizing and get final product.

Described effective ingredient of enriching blood, it is prepared by the raw material of following weight parts and obtains:

Cacumen Platycladi 20 parts, the Flos Sophorae Immaturus 20 parts, Rhizoma Imperatae 20 parts, Radix Cirsii Japonici 15 parts, Radix Angelicae Sinensis 15 parts,

Fructus Schisandrae Chinensis 12 parts, Herba Taraxaci 12 parts, Fructus Forsythiae 12 parts, Fructus Tsaoko 10 parts, 10 parts, Fructus Mori,

Spina Gleditsiae 10 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 parts, Semen Coicis 8 parts, 5 parts, Radix Glycyrrhizae, Pericarpium Citri Reticulatae 5 parts, Rhizoma Dioscoreae 5 parts.

The preparation method of described effective ingredient of enriching blood is as follows:

Take above-mentioned raw materials according to parts by weight, add 2 times of weight 70% ethanol (volume ratio) reflux, extract, twice, each 1-2 hour, merge extractive liquid, filter, be evaporated to 1.1g/ml, then add 1 times of weight water, fully stir, leave standstill 24h, filter, to obtain final product.

Usage and dosage, oral, a 10ml, three times on the one.

Embodiment 3

Effect experiment

Modling model: rat carries out vaginal smear examination in afternoon 16 time, cage is divided by proestrum, oestrus, the later stage of oestrusing, interval by it, in 18 time by proestrum and oestrus rat mate with male rat by 2: 1, when next day morning 8, vaginal smear is observed, to find that sperm was for pregnant 1st day.In the 7th day difference gavage mifepristone (8:00) and misoprostol (18:00), insert quantitative cotton balls one (the heavy 70-80mg of cotton balls in intravaginal simultaneously, half side with plastic sheeting parcel, spill with resistant to blood and backflow with urine).Cotton balls takes out respectively at 8:00 and 18:00 by next day, puts into the airtight stored refrigerated of plastic bag, replaces a new cotton balls in intravaginal simultaneously, observes vaginal hemorrhage situation, continuously to the 14th day, puts to death animal, the every Mus vagina cotton balls collected is carried out amount of bleeding mensuration.

The mensuration of amount of bleeding

Get common carotid artery blood 0.02ml, add in 50gL-1NaOH solution 4ml, mix stand-by.Be placed in respectively in beaker by every the mouse metrorrhagia cotton balls collected, add appropriate 50gL-1NaOH immersion extruding according to the situation of amount of bleeding and wash cotton balls bloodstain by rubbing with the hands, the solution after embathing is poured in another beaker and is preserved.Add appropriate 50gL-1NaOH again and soak cotton balls, bloodstain is washed in extruding by rubbing with the hands, pours preservation container into.According to cotton balls bloodstain elution profile, determine whether embathe 1-2 time again.By successively all lixiviating solution mixings, record 50gL-1NaOH total amount used, get 5ml lixiviating solution to filter, respectively by filtered lixiviating solution 4ml, rat tail vein blood 50gL-1NaOH solution 4ml, be blank with 50gL-1NaOH, in 546nm wavelength record absorbance (A) value.

Pregnant rat is divided at random model group, embodiment 1 group, embodiment 2 groups, matched group (GONGXUENING JIAONANG group), after modeling success, next day (the 8th day), embodiment 1 group, embodiment 2 groups, matched group (GONGXUENING JIAONANG group) be gastric infusion all, the isopyknic normal saline of model group gavage, once a day, continuous 7d.After medication terminates, (gestation the 15th day) is often organized common carotid artery and is got blood examination survey lectin from hemolymph, gets the mensuration that other indexs are carried out in uterus.Medicine on the impact of rat model metrorrhagia amount in table 1:

Table 1

Group	Dosage (g/Kg)	Size of animal	Metrorrhagia amount (ml)
				Model group		20	0.527±0.553
Matched group (GONGXUENING JIAONANG)	0.1	20	0.172±0.133
				Embodiment 1 group	0.1	20	0.152±0.124
Embodiment 2 groups	0.1	20	0.039±0.052

Modeling and administration according to the method described above, detects metrorrhagia amount.The visible rat model of result has certain amount of bleeding, and embodiment 1 and embodiment 2 groups can significantly reduce metrorrhagia amount, and especially embodiment 2 groups achieves significant effect than GONGXUENING JIAONANG.

Embodiment 4

Clinical data

This group amounts to 120 routine functional uterine bleedings and is my institute's Out-patient Clinic of Department of Gynecology and inpatient, at 25 ~ 55 years old age, diagnostic criteria meets in " Chinese medical disease Standardization of diagnosis and curative effect " TCM Gynecology disease metrorrhagia that State Administration of Traditional Chinese Medicine issues disturbs and deficiency of kidney-YIN syndrome in heat in blood.

At random all cases are divided into three groups; Embodiment 1 group 40 example, embodiment 2 group of 40 example, matched group 40 example, three groups of patients are through statistical procedures in age, the course of disease, the state of an illness etc., and difference nonsignificance, has comparability.

Therapeutic Method: matched group takes carbazochrome salicylate, every day 3 times. each 3;

Embodiment 1 group gives pharmaceutical preparation prepared by embodiment 1, each 10ml, every day 3 times;

Embodiment 2 groups gives pharmaceutical preparation prepared by embodiment 2, each 10ml, every day 3 times;

Continuous use 7 days is a course for the treatment of

Curative effect determinate standard: according to related standards evaluation curative effect in " Chinese medical disease Standardization of diagnosis and curative effect " that State Administration of Traditional Chinese Medicine issues.

1. cure: recover normal through amount, menstrual period, cycle, more than 3 menstrual cycle can be maintained, or climacteric women blood stops menopause person.

2. take a turn for the better: though recover normal through amount, menstrual period, cycle, 3 menstrual cycle can not be maintained, or reduce through amount, or menstrual period shorten.

3. do not heal: vaginal hemorrhage is unchanged.

Statistical method adopts t inspection and X ²inspection.

Result: three groups of patient clinical comparitive study are as following table 2:

Table 2

Group	Cure	Take a turn for the better	Do not heal	Total effective rate
					Matched group	13	17	10	75%
Embodiment 1 group	16	15	9	77.5%
					Embodiment 2 groups	29	11	0	100%

Through statistical analysis, there is extremely significant difference in embodiment 2 groups and matched group on clinical efficacy.

Embodiment 5

Ma, 35 years old, puerperal wrinkling lochiorrhea, color secretly has block, waist ventral spine pain, dizzy cardiopalmus, tongue is dim, stringy and hesitant pulse.Ultrasound diagnosis: metrauxe, return to the past bad.Routine blood test: anemia.Once clothes in, Western medicine, curative effect is not good enough.Take one week (course for the treatment of) of pharmaceutical composition of embodiments of the invention 2, abdominal pain disappears, and vaginal hemorrhage stops, and more, tongue arteries and veins is as usual for all diseases, and it is not different from that gynaecological examination and B ultrasonic check uterus adnexa, follows up a case by regular visits to without recurrence.

The present invention is used in the pharmaceutical composition of dysfunctional uterine hemorrhage and postpartum hemorrhage, compatibility is made mutually between various composition, coordinate usefulness, with low cost, through clinical verification, there is good therapeutic effect to dysfunctional uterine hemorrhage, in the applicant's medical practice for many years, the case Numerous of curing, obtains good effect, has broad application prospects.

Claims (3)

1., for a preparation method for the pharmaceutical composition of dysfunctional uterine hemorrhage and postpartum hemorrhage, it is characterized in that:

Get Herba Clinopodii 1000g, decoct with water secondary, each 1.5 hours, collecting decoction, filters, is concentrated into 1.15g/ml, then add 1.7 times of w ethanol, fully stir, after leaving standstill 24h, supernatant is evaporated to 1.1g/ml, then add 1 times of weight water, fully stir, leave standstill 24h, filter, add simple syrup 290ml, sodium benzoate 2.5g, add water to 1000ml, stir fill sterilizing and get final product.

2., for a preparation method for the pharmaceutical composition of dysfunctional uterine hemorrhage and postpartum hemorrhage, it is characterized in that:

Get Herba Clinopodii 800g, decoct with water secondary, each 1.5 hours, collecting decoction, filters, is concentrated into 1.15g/ml, then add 1.7 times of w ethanol, fully stir, after leaving standstill 24h, supernatant is evaporated to 1.1g/ml, then add 1 times of weight water, fully stir, leave standstill 24h, filter, add the effective ingredient 200ml that enriches blood, simple syrup 240ml, sodium benzoate 2.5g, adds water to 1000ml, stirs fill sterilizing and get final product;

Described effective ingredient of enriching blood is prepared by the raw material of following weight parts and obtains:

Cacumen Platycladi 20 parts, the Flos Sophorae Immaturus 20 parts, Rhizoma Imperatae 20 parts, Radix Cirsii Japonici 15 parts, Radix Angelicae Sinensis 15 parts,

Fructus Schisandrae Chinensis 12 parts, Herba Taraxaci 12 parts, Fructus Forsythiae 12 parts, Fructus Tsaoko 10 parts, 10 parts, Fructus Mori,

Spina Gleditsiae 10 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 parts, Semen Coicis 8 parts, 5 parts, Radix Glycyrrhizae, Pericarpium Citri Reticulatae 5 parts, Rhizoma Dioscoreae 5 parts;

The preparation method of described effective ingredient of enriching blood is as follows:

Take above-mentioned raw materials according to parts by weight, add 2 times of weight 70% alcohol reflux twice, each 1-2 hour, merge extractive liquid, filter, be evaporated to 1.1g/ml, then add 1 times of weight water, fully stir, leave standstill 24h, filter, to obtain final product.

3. preparation method described in claim 1-2 is used for the purposes of dysfunctional uterine hemorrhage and postpartum hemorrhage.