CN103751747B - A kind of Chinese medicine of medicine colporrhagia due to abortion disease - Google Patents
A kind of Chinese medicine of medicine colporrhagia due to abortion disease Download PDFInfo
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Abstract
The invention belongs to medical art, relate to a kind of Chinese medicine of medicine colporrhagia due to abortion disease.This Chinese medicine is made up of the raw material of Chinese medicine of following weight: Radix Ginseng 9-15 part, Radix Angelicae Sinensis 20-28 part, Rhizoma Chuanxiong 6-12 part, Semen Persicae 3-9 part, Rhizoma Zingiberis 2-4 part, Radix Glycyrrhizae Preparata 2-4 part, Herba Agrimoniae 20-28 part, Nodus Nelumbinis Rhizomatis 20-28 part, Flos Hibisci Rosae-Sinensis 9-15 part, Radix Rubiae 7-13 part, Herba Schizonepetae charcoal 6-12 part, Cortex Moutan 7-13 part, Colla Corii Asini 7-13 part, Squama Manis 2-4 part, Semen Vaccariae (parched) 3-9 part, Radix Arnebiae (Radix Lithospermi) 3-9 part, Radix Scrophulariae 3-9 part, Radix Notoginseng powder 2-4 part.Clinical test results shows, and applies observation group's cure rate 82.0% of Chinese medicine of the present invention, total effective rate 98.0%; All apparently higher than the cure rate 62.5% of matched group, total effective rate 81.3%, difference has significance (P < 0.05), and vaginal bleeding time is short, and clearing heat in the pericardium rate is low.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of Chinese medicine of medicine colporrhagia due to abortion disease.
Background technology
Drug induced abortion is the remedial measure after contraceptive failure, is the method for termination of pregnancy the most frequently used at present.Mifepristone Plus cycle stratigraphy sheet termination of early pregnancy success rate can reach more than 90%, is drug induced abortion mode the most frequently used clinically at present.But exist clinically drug induced abortion postoperative cause hemorrhage many, the defect that the bleeding time is long.This and medicine stream postoperative because of uterine contraction bad, decidua tissue is discharged not good enough, and blood-stasis internal-depression is relevant.
Summary of the invention
In order to solve above-mentioned technical problem, the invention provides a kind of Chinese medicine of medicine colporrhagia due to abortion disease.
The present invention is realized by following technical scheme:
A Chinese medicine for medicine colporrhagia due to abortion disease, it is made by the raw material of Chinese medicine of following weight:
Radix Ginseng 9-15 part, Radix Angelicae Sinensis 20-28 part, Rhizoma Chuanxiong 6-12 part, Semen Persicae 3-9 part, Rhizoma Zingiberis 2-4 part, Radix Glycyrrhizae Preparata 2-4 part, Herba Agrimoniae 20-28 part, Nodus Nelumbinis Rhizomatis 20-28 part, Flos Hibisci Rosae-Sinensis 9-15 part, Radix Rubiae 7-13 part, Herba Schizonepetae charcoal 6-12 part, Cortex Moutan 7-13 part, Colla Corii Asini 7-13 part, Squama Manis 2-4 part, Semen Vaccariae (parched) 3-9 part, Radix Arnebiae (Radix Lithospermi) 3-9 part, Radix Scrophulariae 3-9 part, Radix Notoginseng powder 2-4 part.
Preferably, the Chinese medicine of above-mentioned medicine colporrhagia due to abortion disease, it is made by the raw material of Chinese medicine of following weight:
Radix Ginseng 11-13 part, Radix Angelicae Sinensis 22-26 part, Rhizoma Chuanxiong 8-10 part, Semen Persicae 5-7 part, Rhizoma Zingiberis 2.5-3.5 part, Radix Glycyrrhizae Preparata 2.5-3.5 part, Herba Agrimoniae 22-26 part, Nodus Nelumbinis Rhizomatis 22-26 part, Flos Hibisci Rosae-Sinensis 11-13 part, Radix Rubiae 9-11 part, Herba Schizonepetae charcoal 8-10 part, Cortex Moutan 9-11 part, Colla Corii Asini 9-11 part, Squama Manis 2.5-3.5 part, Semen Vaccariae (parched) 5-7 part, Radix Arnebiae (Radix Lithospermi) 5-7 part, Radix Scrophulariae 5-7 part, Radix Notoginseng powder 2.5-3.5 part.
Preferred, the Chinese medicine of above-mentioned medicine colporrhagia due to abortion disease, is characterized in that, it is made by the raw material of Chinese medicine of following weight:
Radix Ginseng 12 parts, Radix Angelicae Sinensis 24 parts, Rhizoma Chuanxiong 9 parts, 6 parts, Semen Persicae, Rhizoma Zingiberis 3 parts, Radix Glycyrrhizae Preparata 3 parts, Herba Agrimoniae 24 parts, Nodus Nelumbinis Rhizomatis 24 parts, Flos Hibisci Rosae-Sinensis 12 parts, Radix Rubiae 10 parts, Herba Schizonepetae charcoal 9 parts, Cortex Moutan 10 parts, 10 parts, Colla Corii Asini, Squama Manis 3 parts, Semen Vaccariae (parched) 6 parts, Radix Arnebiae (Radix Lithospermi) 6 parts, Radix Scrophulariae 6 parts, Radix Notoginseng powder 3 parts.
The Chinese medicine of upper medicine colporrhagia due to abortion disease, the dosage form of this Chinese medicine is decoction.
The preparation method of the Chinese medicine of above-mentioned medicine colporrhagia due to abortion disease, step is as follows:
Raw material of Chinese medicine is taken according to above-mentioned weight, by the Radix Ginseng taken, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Semen Persicae, Rhizoma Zingiberis, Radix Glycyrrhizae Preparata, Herba Agrimoniae, Nodus Nelumbinis Rhizomatis, Flos Hibisci Rosae-Sinensis, Radix Rubiae, Herba Schizonepetae charcoal, Cortex Moutan, Squama Manis, Semen Vaccariae (parched), Radix Arnebiae (Radix Lithospermi), Radix Scrophulariae puts into drug-decocting appliance in the lump, the drinking water of injection volume 3-5 times amount is added again in drug-decocting appliance, soak half an hour, make medicine fully moistening, fully fried in order to medicine juice, then boil with high heat and use slow fire again instead and decoct stopping in 15 ~ 20 minutes, elimination medicinal residues, get decoction, again the Colla Corii Asini taken is added molten in decoction, add Radix Notoginseng powder stir and get final product.
Chinese medicine of the present invention has benefiting qi and nourishing blood, nourishing YIN and clearing away heat, effect of blood stasis dispersing and fresh blood promoting, for vagina bleeding after miscarriage with drugs disease.
The instructions of taking of decoction of the present invention is as follows:
Every day twice, each serving with 600 ~ 800 milliliters; The upper and lower noon is each once, within two hours, takes medicine after the meal; Decoction being taken warmly.
Taboo item: sticky, solid hard cold, food nondigestible and excitatory are exploded in treatment, period in a medicine taboo edible oil.
By clinical experience for many years, applicant thinks that vaginal bleeding after drug abortion disease is deficiency of both QI and YIN, can not caused by astringency inducing blood, in treatment should with the main assistant of QI invigorating nourishing YIN and benefiting blood with hemostasis for method.
In the Chinese medicine of medicine colporrhagia due to abortion disease of the present invention, reuse ginseng and Chinese angelica root strongly invigorating QI and blood, astringency inducing dai channel; Rhizoma Chuanxiong, Semen Persicae, Squama Manis, Semen Vaccariae (parched) blood circulation promoting and blood stasis dispelling, for promoting that the intrauterine lochia of commotio retinae is discharged, so that blood stasis dispersing and fresh blood promoting; Rhizoma Zingiberis, Herba Schizonepetae charcoal, the hemostasis of Radix Glycyrrhizae Preparata temperature palace; Herba Agrimoniae, Nodus Nelumbinis Rhizomatis, Flos Hibisci Rosae-Sinensis, Radix Rubiae, Cortex Moutan, Radix Arnebiae (Radix Lithospermi), the hemostasis of Radix Scrophulariae nourishing YIN and clearing away heat; Colla Corii Asini hemostasis is enriched blood; Pseudo-ginseng hemostatic is invigorated blood circulation.All medicines share, and play benefiting qi and nourishing blood altogether, nourishing YIN and clearing away heat, effect of blood stasis dispersing and fresh blood promoting.Chinese medicine of the present invention, both can medicine colporrhagia post-abortion, can also promote that intrauterine lochia is discharged simultaneously, the recovery of the body constitution of acceleration commotio retinae women.
Decoction of the present invention preparation easily, taking convenience, evident in efficacy, can also effectively hemorrhage after prevention of miscarriage, infection etc., promote that post-abortion, physical function recovered, have very important effect to raising women of child-bearing age healthy reproduction, carrying out of family planning work of propelling.Clinical test results shows, and applies observation group's cure rate 82.0% of Chinese medicine of the present invention, total effective rate 98.0%; All apparently higher than the cure rate 62.5% of matched group, total effective rate 81.3%, difference has significance (P < 0.05), and vaginal bleeding time is short, and clearing heat in the pericardium rate is low.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.
Embodiment 1
Radix Ginseng 12g, Radix Angelicae Sinensis 24g, Rhizoma Chuanxiong 9g, Semen Persicae 6g, Rhizoma Zingiberis 3g, Radix Glycyrrhizae Preparata 3g, Herba Agrimoniae 24g, Nodus Nelumbinis Rhizomatis 24g, Flos Hibisci Rosae-Sinensis 12g, Radix Rubiae 10g, Herba Schizonepetae charcoal 9g, Cortex Moutan 10g, Colla Corii Asini 10g, Squama Manis 3g, Semen Vaccariae (parched) 6g, Radix Arnebiae (Radix Lithospermi) 6g, Radix Scrophulariae 6g, Radix Notoginseng powder 3g.
Raw material of Chinese medicine is taken according to above-mentioned weight, by the Radix Ginseng taken, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Semen Persicae, Rhizoma Zingiberis, Radix Glycyrrhizae Preparata, Herba Agrimoniae, Nodus Nelumbinis Rhizomatis, Flos Hibisci Rosae-Sinensis, Radix Rubiae, Herba Schizonepetae charcoal, Cortex Moutan, Squama Manis, Semen Vaccariae (parched), Radix Arnebiae (Radix Lithospermi), Radix Scrophulariae puts into drug-decocting appliance in the lump, the drinking water of injection volume 4 times amount is added again in drug-decocting appliance, soak half an hour, make medicine fully moistening, fully fried in order to medicine juice, then boil with high heat and use slow fire again instead and decoct stopping in 20 minutes, elimination medicinal residues, get decoction, again the Colla Corii Asini taken is added molten in decoction, add Radix Notoginseng powder stir and get final product.
Embodiment 2
Radix Ginseng 11g, Radix Angelicae Sinensis 26g, Rhizoma Chuanxiong 8g, Semen Persicae 7g, Rhizoma Zingiberis 2.5g, Radix Glycyrrhizae Preparata 3.5g, Herba Agrimoniae 22g, Nodus Nelumbinis Rhizomatis 26g, Flos Hibisci Rosae-Sinensis 11g, Radix Rubiae 11g, Herba Schizonepetae charcoal 8g, Cortex Moutan 11g, Colla Corii Asini 9g, Squama Manis 3.5g, Semen Vaccariae (parched) 5g, Radix Arnebiae (Radix Lithospermi) 7g, Radix Scrophulariae 5g, Radix Notoginseng powder 3.5g.
Raw material of Chinese medicine is taken according to above-mentioned weight, by the Radix Ginseng taken, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Semen Persicae, Rhizoma Zingiberis, Radix Glycyrrhizae Preparata, Herba Agrimoniae, Nodus Nelumbinis Rhizomatis, Flos Hibisci Rosae-Sinensis, Radix Rubiae, Herba Schizonepetae charcoal, Cortex Moutan, Squama Manis, Semen Vaccariae (parched), Radix Arnebiae (Radix Lithospermi), Radix Scrophulariae puts into drug-decocting appliance in the lump, the drinking water of injection volume 3 times amount is added again in drug-decocting appliance, soak half an hour, make medicine fully moistening, fully fried in order to medicine juice, then boil with high heat and use slow fire again instead and decoct stopping in 15 minutes, elimination medicinal residues, get decoction, again the Colla Corii Asini taken is added molten in decoction, add Radix Notoginseng powder stir and get final product.
Embodiment 3
Radix Ginseng 13g, Radix Angelicae Sinensis 22g, Rhizoma Chuanxiong 10g, Semen Persicae 5g, Rhizoma Zingiberis 3.5g, Radix Glycyrrhizae Preparata 2.5g, Herba Agrimoniae 26g, Nodus Nelumbinis Rhizomatis 22g, Flos Hibisci Rosae-Sinensis 13g, Radix Rubiae 9g, Herba Schizonepetae charcoal 10g, Cortex Moutan 9g, Colla Corii Asini 11g, Squama Manis 2.5g, Semen Vaccariae (parched) 7g, Radix Arnebiae (Radix Lithospermi) 5g, Radix Scrophulariae 7g, Radix Notoginseng powder 2.5g.
Raw material of Chinese medicine is taken according to above-mentioned weight, by the Radix Ginseng taken, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Semen Persicae, Rhizoma Zingiberis, Radix Glycyrrhizae Preparata, Herba Agrimoniae, Nodus Nelumbinis Rhizomatis, Flos Hibisci Rosae-Sinensis, Radix Rubiae, Herba Schizonepetae charcoal, Cortex Moutan, Squama Manis, Semen Vaccariae (parched), Radix Arnebiae (Radix Lithospermi), Radix Scrophulariae puts into drug-decocting appliance in the lump, the drinking water of injection volume 5 times amount is added again in drug-decocting appliance, soak half an hour, make medicine fully moistening, fully fried in order to medicine juice, then boil with high heat and use slow fire again instead and decoct stopping in 20 minutes, elimination medicinal residues, get decoction, again the Colla Corii Asini taken is added molten in decoction, add Radix Notoginseng powder stir and get final product.
Embodiment 4
Radix Ginseng 9g, Radix Angelicae Sinensis 20g, Rhizoma Chuanxiong 6g, Semen Persicae 3g, Rhizoma Zingiberis 2g, Radix Glycyrrhizae Preparata 2g, Herba Agrimoniae 20g, Nodus Nelumbinis Rhizomatis 20g, Flos Hibisci Rosae-Sinensis 9g, Radix Rubiae 7g, Herba Schizonepetae charcoal 6g, Cortex Moutan 7g, Colla Corii Asini 7g, Squama Manis 2g, Semen Vaccariae (parched) 3g, Radix Arnebiae (Radix Lithospermi) 3g, Radix Scrophulariae 3g, Radix Notoginseng powder 2g.
Preparation method is with embodiment 1.
Embodiment 5
Radix Ginseng 15g, Radix Angelicae Sinensis 28g, Rhizoma Chuanxiong 12g, Semen Persicae 9g, Rhizoma Zingiberis 4g, Radix Glycyrrhizae Preparata 4g, Herba Agrimoniae 28g, Nodus Nelumbinis Rhizomatis 28g, Flos Hibisci Rosae-Sinensis 15g, Radix Rubiae 13g, Herba Schizonepetae charcoal 12g, Cortex Moutan 13g, Colla Corii Asini 13g, Squama Manis 4g, Semen Vaccariae (parched) 9g, Radix Arnebiae (Radix Lithospermi) 9g, Radix Scrophulariae 9g, Radix Notoginseng powder 4g.
Preparation method is with embodiment 1.
Carried out clinical trial to the Chinese medicine of the embodiment of the present invention 1, Details as Follows:
1 data and method
1.1 object of study
Carry out 196 examples of drug induced abortion, the healthy women of reproductive age of menolipsis 49d, age < 40 years old.Through gynecologial examination urinary chorionic gonadotropin (HCG).B ultrasonic turns out to be uterine pregnancy, without drug induced abortion contraindication, is divided into observation group 100 example and matched group 96 example immediately.
The every sheet 25mg of 1.2 medicine mifepristone (Hualian Pharmaceutical Co., Ltd., Shanghai's production); cycle stratigraphy sheet every sheet 200 μ g (Hualian Pharmaceutical Co., Ltd., Shanghai's production), the Chinese medicine of medicine colporrhagia due to abortion disease prepared by the embodiment of the present invention 1.
1.3 administering mode women gestations treatments took mifepristone 50mg morning 9 on the same day, and evening 9 takes mifepristone 25mg, and take mifepristone 25mg in the 2nd day morning 9, and evening 9 takes mifepristone 50mg, and take cycle stratigraphy sheet 600 μ g in the 3rd day morning 7.In 3d, the front and back 2h that takes medicine on an empty stomach, advises patient to prohibit during taking said medicine and takes other drug.3rd day morning 8, Dian Lai hospital was observed, after pregnant capsule is discharged, matched group and observation group all give oxytocin 10U intramuscular injection, observation group's routine gives 5 doses, the Chinese medicine of medicine colporrhagia due to abortion disease prepared by inventive embodiments 1, every day, potion took 5d altogether, every day takes for twice sooner or later, each 600-800ml.Matched group gives oral carbazochrome salicylate 5mg every day the secondary 5d that takes medicine altogether.
1.4 curative effect judging standards are cured: hemostasis in the 7d that takes medicine; Effective: the 14d that takes medicine stops blooding; Invalid: hemorrhage more than 14d or need the clearing heat in the pericardium after taking medicine.Cure and add effectively for effectively total.
2 results
2.1 observation of curative effect group cure rates 82.0%, total effective rate 98.0%; Matched group cure rate 62.5%, total effective rate 81.3%.Two groups of cure rates carry out X 2 test V
2=8.78, P < 0.05; Two groups of total effective rates carry out X 2 test V
2=7.66, P < 0.01, both all have significance at difference.In table 1.
A table 1 liang group curative effect of medication compares
| Group | Number of cases | Cure (%) | Effectively (%) | Invalid (%) | Total effective rate (%) |
| Observation group | 100 | 82(80.0) | 15(15.0) | 2(3.0) | 98(98.0) |
| Matched group | 96 | 60(62.5) | 18(18.8) | 13(13.5) | 78(81.3) |
2.2 vaginal bleeding time and clearing heat in the pericardium rate take medicine 8d have no foetal sac discharge, or after foetal sac is got rid of, hemorrhage more, B ultrasonic confirms that embryo exists or has Slough film to remain, and carries out uterine curettage, if foetal sac is discharged, but still have hemorrhage on a small quantity after taking medicine 2 weeks, B ultrasonic confirms without Hemorrhage, according to clinical setting, continue observation 1 week, take the circumstances into consideration to use hemorrhage.Observation group's vaginal bleeding time is shorter than matched group, and difference has significance (P < 0.05); Observation group's clearing heat in the pericardium rate is lower than matched group, but no significant difference (P > 0.05).In table 2.
Table 2 liang group vaginal bleeding time and clearing heat in the pericardium situation compare
| Group | Number of cases | Vaginal bleeding time (d) | Clearing heat in the pericardium example (%) |
| Observation group | 100 | 8.02±2.15 | 2 |
| Matched group | 96 | 10.78±3.05 | 5 |
| T or V 2Value | 4.21 | 0.68 | |
| P value | P＜0.05 | P＞0.05 |
Clinical test results shows, and applies observation group's cure rate 82.0% of Chinese medicine of the present invention, total effective rate 98.0%; All apparently higher than the cure rate 62.5% of matched group, total effective rate 81.3%, difference has significance (P < 0.05), and vaginal bleeding time is short, and clearing heat in the pericardium rate is low.
Claims (5)
1. a Chinese medicine for medicine colporrhagia due to abortion disease, is characterized in that, it is made by the raw material of Chinese medicine of following weight:
Radix Ginseng 9-15 part, Radix Angelicae Sinensis 20-28 part, Rhizoma Chuanxiong 6-12 part, Semen Persicae 3-9 part, Rhizoma Zingiberis 2-4 part, Radix Glycyrrhizae Preparata 2-4 part, Herba Agrimoniae 20-28 part, Nodus Nelumbinis Rhizomatis 20-28 part, Flos Hibisci Rosae-Sinensis 9-15 part, Radix Rubiae 7-13 part, Herba Schizonepetae charcoal 6-12 part, Cortex Moutan 7-13 part, Colla Corii Asini 7-13 part, Squama Manis 2-4 part, Semen Vaccariae (parched) 3-9 part, Radix Arnebiae (Radix Lithospermi) 3-9 part, Radix Scrophulariae 3-9 part, Radix Notoginseng powder 2-4 part.
2. the Chinese medicine of medicine colporrhagia due to abortion disease according to claim 1, is characterized in that, it is made by the raw material of Chinese medicine of following weight:
Radix Ginseng 11-13 part, Radix Angelicae Sinensis 22-26 part, Rhizoma Chuanxiong 8-10 part, Semen Persicae 5-7 part, Rhizoma Zingiberis 2.5-3.5 part, Radix Glycyrrhizae Preparata 2.5-3.5 part, Herba Agrimoniae 22-26 part, Nodus Nelumbinis Rhizomatis 22-26 part, Flos Hibisci Rosae-Sinensis 11-13 part, Radix Rubiae 9-11 part, Herba Schizonepetae charcoal 8-10 part, Cortex Moutan 9-11 part, Colla Corii Asini 9-11 part, Squama Manis 2.5-3.5 part, Semen Vaccariae (parched) 5-7 part, Radix Arnebiae (Radix Lithospermi) 5-7 part, Radix Scrophulariae 5-7 part, Radix Notoginseng powder 2.5-3.5 part.
3. the Chinese medicine of medicine colporrhagia due to abortion disease according to claim 2, is characterized in that, it is made by the raw material of Chinese medicine of following weight:
Radix Ginseng 12 parts, Radix Angelicae Sinensis 24 parts, Rhizoma Chuanxiong 9 parts, 6 parts, Semen Persicae, Rhizoma Zingiberis 3 parts, Radix Glycyrrhizae Preparata 3 parts, Herba Agrimoniae 24 parts, Nodus Nelumbinis Rhizomatis 24 parts, Flos Hibisci Rosae-Sinensis 12 parts, Radix Rubiae 10 parts, Herba Schizonepetae charcoal 9 parts, Cortex Moutan 10 parts, 10 parts, Colla Corii Asini, Squama Manis 3 parts, Semen Vaccariae (parched) 6 parts, Radix Arnebiae (Radix Lithospermi) 6 parts, Radix Scrophulariae 6 parts, Radix Notoginseng powder 3 parts.
4. the Chinese medicine of the medicine colporrhagia due to abortion disease according to claim 1 or 2 or 3, is characterized in that, the dosage form of this Chinese medicine is decoction.
5. the preparation method of the Chinese medicine of claim 1 or the medicine colporrhagia due to abortion disease described in 2 or 3, step is as follows:
Raw material of Chinese medicine is taken according to above-mentioned weight, by the Radix Ginseng taken, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Semen Persicae, Rhizoma Zingiberis, Radix Glycyrrhizae Preparata, Herba Agrimoniae, Nodus Nelumbinis Rhizomatis, Flos Hibisci Rosae-Sinensis, Radix Rubiae, Herba Schizonepetae charcoal, Cortex Moutan, Squama Manis, Semen Vaccariae (parched), Radix Arnebiae (Radix Lithospermi), Radix Scrophulariae puts into drug-decocting appliance in the lump, the drinking water of injection volume 3-5 times amount is added again in drug-decocting appliance, soak half an hour, make medicine fully moistening, fully fried in order to medicine juice, then boil with high heat and use slow fire again instead and decoct stopping in 15 ~ 20 minutes, elimination medicinal residues, get decoction, again the Colla Corii Asini taken is added molten in decoction, add Radix Notoginseng powder stir and get final product.
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| C06 | Publication | ||
| PB01 | Publication | ||
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| C14 | Grant of patent or utility model | ||
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Address after: 250200 Shandong city of Ji'nan province Zhangqiu Mingshui Road No. 1281 Tang maternal and Child Health Hospital of Zhangqiu City Department of gynecology and obstetrics Patentee after: Qu Hongcui Address before: 250200 Shandong city of Ji'nan province Zhangqiu Mingshui Tang Road No. 1281 Zhangqiu young women health hospital of Obstetrics and Gynecology Patentee before: Qu Hongcui |
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| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160309 Termination date: 20170116 |