CN105194309A - Externally used paste for treating osteoporosis and preparation method thereof - Google Patents

Abstract

The invention discloses an externally used paste for treating osteoporosis and a preparation method thereof. The externally used paste is prepared from the following main raw medicinal materials in parts by weight: 8-14 parts of common macrocarpium fruit, 7-12 parts of root of java campanumoea, 9-13 parts of fragrant solomonseal rhizome, 6-10 parts of Japanese ardisia herb, 9-15 parts of mussel, 8-13 parts of tree peony bark, 5-10 parts of root of common fordia, 4-9 parts of herb of sibirica walking fern, 8-15 parts of milkvetch root, 9-14 parts of root of wallich swallowwort, 10-16 parts of purpleback murdannia, 7-15 parts of Himalayan teasel root, 9-12 parts of root of bilobed grewia, 8-16 parts of glossy privet fruit and 7-13 parts of leaf of falsesour cherry. The externally used paste disclosed by the invention is safe and efficient, does not have side effects, and is wide in medicinal raw material sources and relatively low in price. By using the externally used paste, the treatment cost is relatively low, the symptoms of osteoporosis can be treated fundamentally, both symptoms and root causes can be treated, relapse is avoided, and complications are avoided, so that the externally used paste is worthy of popularization and application.

Description

Treat osteoporotic externally used paste and preparation method

Technical field

The present invention relates to traditional Chinese medicine field, particularly relate to one and treat osteoporotic externally used paste and preparation method.

Background technology

Osteoporosis and osteoporosis, be one group of osteopathia that many reasons causes, osseous tissue has normal calcification, and calcium salt and substrate are normal rates, and the metabolic osteopathy being reduced to feature with unit volume inner bone tissues amount becomes.In most osteoporosis, caused by the minimizing of osseous tissue increases mainly due to bone absorption.With skeleton pain, be easy to fracture for feature.Clinical manifestation: 1. pain.The modal symptom of primary osteoporosis, common with lumbago and backache, account for 70% ~ 80% in pain patients.Pain spreads along spinal column to both sides, lie on the back or seat time pain relief, stretch after time upright or standing for a long time, sitting time the pain increased, bend over, cough, increase the weight of when defecating firmly.Osteodynia can be there is when general bone loss more than 12%.During senile osteoporosis, Vertebral Compression is out of shape, flexion of vertebral column, and muscle fatigue is spasm even, produces pain.Recently compressed fracture of thoracic vertebra and lumber vertebra, also can produce acute pain, and the spinous process of corresponding site can have strong tenderness and percussion pain.If oppress corresponding spinal nerves can produce extremity radiating pain, two lower limb sensorimotor obstacle, intercostal neuralgia, the similar angina pectoris of retrosternal pain.If compressing spinal cord, cauda equina nerve also affect bladder, rectum function.2. height shortening, hunchback.How to occur after pain.The anterior loading weight of vertebra vertebral body is large, especially the 11st, 12 thoracic vertebras and the 3rd lumbar vertebra, loading is larger, easy compression, vertebra is leaned forward, formed bow-backed, with age, osteoporosis increases the weight of, bow-backed curvature strengthens, Vertebral Compression during senile osteoporosis, every vertebral body shortens 2 millimeter, height shorten in average 3 ~ 6 centimetres.3. fracture is the most common and the most serious complication of degeneration osteoporosis.4. respiratory function declines.Thoracolumbar vertebrae compression fracture, vertebra palintrope, chest deformity, can make vital capacity and maximal breathing capacity significantly reduce, patient often can occur uncomfortable in chest, breathe hard, the symptom such as dyspnea.

Treatment: effective measures have following several.1. move.Growing up, polytype motion contributes to the maintenance of bone amount.Menopausal women adheres to weekly the motion of 3 hours, and overall calcium increases.But hyperkinesia causes amenorrhea person, bone loss is accelerated on the contrary.Motion can also improve sensitivity and balanced capacity, encourages patients with osteoporosis multi-activity as much as possible.2. nutrition.Good nutrition is significant for prevention of osteoporosis disease, comprises enough calcium, vitamin D, vitamin C and protein.From the Childhood, diet should have enough calcium to take in, and calcium affects the acquisition of peak bone mass.3. prevention wrestling.Patients with osteoporosis should be reduced as far as possible fall down probability, to reduce hip fracture and Colles fracture.4. Drug therapy.Effective Drug therapy can stop and treat osteoporosis, comprises estrogen replacement therapy, calcitonin, selective estrogen receptor modulators and diphosphate, and these medicines can stop bone resorption but little especially to osteoplastic effect.Be used for the treatment of and stop the medicine that osteoporosis develops to be divided into two large classes, the first kind, for suppressing bone resorption medicine, comprises calcium preparation, vitamin D and activated vitamin D, calcitonin, diphosphate, estrogen and isoflavone; Equations of The Second Kind, for promoting bone patent medicine, comprises fluoride, desogestrel, parathyroid hormone and isoflavone.(1) hormone replacement therapy.Hormone replacement therapy is considered to the optimum selection for the treatment of postmenopausal osteoporosis, and be also the most effective Therapeutic Method, Problems existing is the untoward reaction that hormone replacement therapy may bring other system.Hormone replacement therapy avoids the patient for suffering from mastopathy, and can not tolerate its side effect person.(2) selective estrogen receptor modulators.Such medicine has weak estrogen-like effects at some organ, and can play estrogenic antagonism at other organs.This kind of medicine has raloxifene, for nonsteroidal benzene a pair of horses going side by side thiophene is estrogenic excitomotor, can suppress bone resorption, increase the BMD of spinal column and hip, the danger of vertebral fracture can be made to decline 40% ~ 50%, but curative effect comparatively estrogen is poor.Pre-menopausal women is forbidden.(3) diphosphonic acid salt.Diphosphonic acid salt is the synthetic analog of the pyrophosphate combined with hydroxyapatite in skeleton, the bone resorption of Osteoclasts mediate can be suppressed and increases bone density by specificity, concrete mechanism is completely unclear yet, considers relevant with the function of adjustment osteoclast and activity.Forbid the women in anemia of pregnant woman and plan pregnancy.(4) calcitonin.Calcitonin is a kind of peptide hormone, osteoclast activity can be suppressed fast, slow effect can reduce the quantity of osteoclast, there is pain relieving, increase movable function and improve the function of calcium balance, patient for fracture has the effect of pain relieving, is applicable to diphosphate and estrogen has contraindication or not tolerant patient.Domestic conventional preparation has calcitonin (Miacalcin, salmon calcitonin see calcimar) and elcatonin (elcatonin).Calcitonin has Parenteral administration and intranasal administration 2 kinds of modes, and the action time of parenteral is sustainable reaches 20 months.(5) vitamin D and calcium.Vitamin D and metabolite thereof can promote the absorption of small intestinal calcium and the mineralising of bone, and activated vitamin D (as Rocaltrol, alfacalcidol) can promoting bone growing, increase the generation of Bone Gla protein and the activity of alkali phosphatase.Take activated vitamin D to take more merely calcium preparation and more can reduce the incidence rate that patients with osteoporosis vertebral body and vertebral body fracture outward.Separately have the combination formulations of vitamin D and calcium available, therapeutic effect is reliable.(6) fluoride.Fluoride is osteoplastic active stimulus, can increase vertebral body and femoral neck bone mineral density, reduces vertebral fracture incidence rate.Every day, low dose of fluorine, can stimulate bone formation and side effect is little effectively.The effective ingredient of tridin (Tridin) is single fluorophosphoric acid glutamine and calcium gluconate, chews clothes with during dining.5. surgical intervention.Only after fracturing because of osteoporosis, just need surgical intervention.

Application publication number CN104547408A(application number 201310515381.2) Chinese patent literature disclose one and treat osteoporotic Chinese medicine decoction, described formula forms by following weight: Carapax et Plastrum Testudinis 18-28 gram, Radix Salviae Miltiorrhizae 12-18 gram, hair Rhizoma Zingiberis Recens 13-17 gram, Caulis Spatholobi 13-17 gram, Radix Rehmanniae Preparata 18-22 gram, herba cistanches 8-12 gram, Semen Cuscutae 8-12 gram, RHIIZOMA DIOSCOREAE fr0m Henan of China 8-12 gram, Fructus Lycii 13-17 gram, gun additioner 8-12 gram, Herba Pyrolae 13-17 gram, Cortex Eucommiae 8-12 gram, Cortex Cinnamomi 1-5 gram.Application publication number CN104740080A(application number 201510092644.2) Chinese patent literature disclose one and treat osteoporotic Chinese medicine preparation, be made up of following raw material Chinese medicine: Radix Angelicae Sinensis 15g, Rhizoma Chuanxiong 10g, Radix Stephaniae Tetrandrae 30g, Radix Salviae Miltiorrhizae 15g, Poria 15g, Colla cornus cervi (melting) 10g, Herba Epimedii 10g, Radix Angelicae Pubescentis 10g, Radix Angelicae Dahuricae 10g, Herba Lycopodii 15g, Rhizoma Drynariae 10g, Cortex Eucommiae 6g, Radix Glycyrrhizae 6g, Fructus Lycii 6g, Flos Carthami 3g, Radix Astragali 10g, Radix Paeoniae Rubra 12g.Application publication number CN104825652A(application number 201510209928.5) Chinese patent literature disclose one and treat osteoporotic Chinese medicine preparation, be made up of following Chinese medicine ingredients by weight: Margarita powder 10-15 part, Endothelium Corneum Gigeriae Galli 12-15 part, Radix Clematidis 12-15 part, Caulis Spatholobi 12-15 part, Placenta Hominis powder 10-12 part, Fructus Lycii 9-12 part, Radix Rehmanniae Preparata 9-12 part, Poria 8-12 part, Radix Dipsaci 8-12 part, Semen Persicae 8-12 part, Pheretima 9-12 part, Eupolyphaga Seu Steleophaga 6-10 part, Radix Notoginseng 9-12 part, Radix Angelicae Sinensis 9-15 part, Radix Aconiti Lateralis Preparata 5-8 part, Colla Corii Asini 8-12 part, Cortex Moutan 8-12 part, Cortex Eucommiae 9-13 part and Radix Cyathulae 9-13 part.

At present, mainly Drug therapy is relied on for osteoporotic treatment, comprise estrogen replacement therapy, calcitonin, selective estrogen receptor modulators and diphosphate etc.These medicines can stop bone resorption, but little especially to osteoplastic effect, therefore can not fundamentally solve osteoporotic disease.In addition, these medicines are mostly expensive, are difficult to extensive use, and have comparatively significantly side effect, even can cause comparatively serious complication.

Summary of the invention

For the deficiencies in the prior art, the object of this invention is to provide one and treat osteoporotic externally used paste and preparation method.The present invention is safe and effective, has no side effect, and medicine source is extensive and price is lower, and medical expense is lower, can fundamentally solve osteoporotic disease, treating both the principal and secondary aspects of a disease, not easily recur, avoid the generation of complication, be worthy of popularization.

Technical scheme of the present invention is:

Treat osteoporotic externally used paste, take off the primary raw material medicine stating weight proportion and be prepared from: Fructus Corni 8-14, Radix Campanumoeae 7-12, Rhizoma Polygonati Odorati 9-13, PINGDIMU 6-10, Mytilus 9-15, Cortex Moutan 8-13, Radix Fordiae Cauliflorae 5-10, Herba Camptosori Sibirici 4-9, Radix Astragali 8-15, Radix cynanchi wallichii 9-14, Herba Murdanniae Divergentis 10-16, Radix Dipsaci 7-15, Radix grewiae bilobae 9-12, Fructus Ligustri Lucidi 8-16, Folium Pruni pseudocerasi 7-13.

Treat osteoporotic externally used paste, preferred scheme is, takes off the primary raw material medicine stating weight proportion and is prepared from: Fructus Corni 10-13, Radix Campanumoeae 8-11, Rhizoma Polygonati Odorati 10-12, PINGDIMU 7-9, Mytilus 11-14, Cortex Moutan 9-12, Radix Fordiae Cauliflorae 7-9, Herba Camptosori Sibirici 5-8, Radix Astragali 10-13, Radix cynanchi wallichii 11-13, Herba Murdanniae Divergentis 12-14, Radix Dipsaci 9-13, Radix grewiae bilobae 10-11, Fructus Ligustri Lucidi 11-14, Folium Pruni pseudocerasi 10-12.

Treat osteoporotic externally used paste, the scheme be more preferably is, takes off the primary raw material medicine stating weight proportion and is prepared from: Fructus Corni 11, Radix Campanumoeae 10, Rhizoma Polygonati Odorati 11, PINGDIMU 8, Mytilus 13, Cortex Moutan 10, Radix Fordiae Cauliflorae 8, Herba Camptosori Sibirici 7, the Radix Astragali 12, Radix cynanchi wallichii 12, Herba Murdanniae Divergentis 13, Radix Dipsaci 12, Radix grewiae bilobae 10.5, Fructus Ligustri Lucidi 12, Folium Pruni pseudocerasi 11.

The preparation method of the osteoporotic externally used paste of above-mentioned treatment is:

(1) get Fructus Corni, put into 125-160 DEG C of hot pot, constantly stir-fry, fry 7-12 minute, take out, be ground into fine powder, cross No. 7 sieves;

(2) cleaned by Mytilus, soak 2.5-4 hour with rice wine, the amount of rice wine is 3.5-4.8 times of Mytilus weight, steams 85-120 minute with food steamer, takes out, dries, pulverization, cross No. 7 sieves;

(3) get Fructus Ligustri Lucidi, clean, with vinegar, every 100g Fructus Ligustri Lucidi, with vinegar 10-16g, is mixed thoroughly, and moistening 2.5-4 hour, dries, pulverization, crosses No. 7 sieves;

(4) all the other the 12 taste crude drug except Fructus Corni, Mytilus and Fructus Ligustri Lucidi are put into pot, soak 50 minutes, amount of water is 5.5-8 times of 12 taste crude drug gross weights, turn little fire after intense fire boils and decoct 40-65 minute, leach medicinal liquid, add 12 taste crude drug gross weight 4.2-6.5 water doubly, continue decoction 40 minutes, leach medicinal liquid, merge twice medicinal liquid;

(5) by step (4) gained medicinal liquid centrifugalize 10-15 minute, centrifugal speed is 4200-5000r/min, relative density supernatant concentration is become to be the clear paste of 1.21-1.25, add step (1), step (2) and step (3) gained, stir, put into 60 DEG C of baking ovens dry 16 hours, take out, be ground into fine powder, cross No. 7 sieves;

(6) join in the vaseline of molten by step (5) gained, the amount of vaseline is 2.2-3.6 times of step (5) gained fine powder weight, stirs into paste, to obtain final product.

Preferably be, in step (1), to put into 130-150 DEG C of hot pot.

Preferably be in step (1), 8-10 minute.

Preferably be in step (2), 3-3.5 hour.

Preferably be in step (2), the amount of rice wine is the 3.8-4.4 times of Mytilus weight.

Preferably be in step (2), steam 90-110 minute with food steamer.

Preferably be that, in step (3), every 100g Fructus Ligustri Lucidi is with vinegar 12-15g.

Preferably be in step (3), moistening 3-3.6 hour.

Preferably be in step (4), amount of water is 5.8-7.4 times of 12 taste crude drug gross weights.

Preferably be in step (4), turn little fire after intense fire boils and decoct 45-60 minute.

Preferably be in step (4), add 12 taste crude drug gross weight 4.5-6 water doubly.

Preferably be in step (5), by step (4) gained medicinal liquid centrifugalize 11-13 minute.

Preferably be that, in step (5), centrifugal speed is 4500-4800r/min.

Preferably be in step (5), supernatant concentration become relative density to be the clear paste of 1.22-1.24.

Preferably be in step (6), the amount of vaseline is 2.5-3.2 times of step (5) gained fine powder weight.

Be more preferably, in step (1), put into 140 DEG C of hot pots.

Be more preferably, fry 9 minutes in step (1).

Be more preferably, step soaks 3.2 hours with rice wine in (2).

Be more preferably, in step (2), the amount of rice wine is 4 times of Mytilus weight.

Be more preferably, in step (2), steam 100 minutes with food steamer.

Be more preferably, in step (3), every 100g Fructus Ligustri Lucidi is with vinegar 14g.

Be more preferably, moistening 3.4 hours in step (3).

Be more preferably, in step (4), amount of water is 6.6 times of 12 taste crude drug gross weights.

Be more preferably, in step (4), intense fire turns little fire decoction 55 minutes after boiling.

Be more preferably, in step (4), add the water of 12 taste crude drug gross weight 5.6 times.

Be more preferably, by step (4) gained medicinal liquid centrifugalize 12 minutes in step (5).

Be more preferably, in step (5), centrifugal speed is 4600r/min.

Be more preferably, in step (5), supernatant concentration is become relative density be 1.23 clear paste.

Be more preferably, in step (6), the amount of vaseline is 2.8 times of step (5) gained fine powder weight.

The osteoporotic externally used paste for the treatment of provided by the invention, prescription is rigorous, compatibility science.In addition, excellent results of the present invention also shows:

1, safe and effective, have no side effect;

2, medicine source extensively and price is lower, and medical expense is lower, alleviates patient economy burden;

3, treating both the principal and secondary aspects of a disease, not easily recurs, and avoids the generation of complication;

4, preparation method is simple, and products obtained therefrom is easy to use;

5, there is effect of liver and kidney tonifying, invigorating the spleen and benefiting QI, blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, bone and muscle strengthening, scalable organism endocrine, alcium and phosphor metabolization, immune system, the systems such as trace element, recover bone metabolism balance, promote the absorption of the trace element such as calcium, phosphorus and protein, vitamin D, effective raising bone mass and bone density, can fundamentally solve osteoporotic disease, finally reaches and cure osteoporotic object.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.

embodiment 1treat osteoporotic externally used paste, the primary raw material medicine getting following weight parts is prepared from (every part is 400g): Fructus Corni 8 parts, Radix Campanumoeae 7 parts, Rhizoma Polygonati Odorati 9 parts, PINGDIMU 6 parts, Mytilus 9 parts, Cortex Moutan 8 parts, Radix Fordiae Cauliflorae 5 parts, Herba Camptosori Sibirici 4 parts, the Radix Astragali 8 parts, Radix cynanchi wallichii 9 parts, Herba Murdanniae Divergentis 10 parts, Radix Dipsaci 7 parts, Radix grewiae bilobae 9 parts, Fructus Ligustri Lucidi 8 parts, Folium Pruni pseudocerasi 7 parts.

The preparation method of the osteoporotic externally used paste of above-mentioned treatment is:

(1) get Fructus Corni, put into 125 DEG C of hot pots, constantly stir-fry, fry 7 minutes, take out, be ground into fine powder, cross No. 7 sieves;

(2) cleaned by Mytilus, soak 2.5 hours with rice wine, the amount of rice wine is 3.5 times of Mytilus weight, steams 85 minutes with food steamer, takes out, dries, pulverization, crosses No. 7 sieves;

(3) get Fructus Ligustri Lucidi, clean, with vinegar, every 100g Fructus Ligustri Lucidi, with vinegar 10g, is mixed thoroughly, and moistening 2.5 hours, dries, pulverization, crosses No. 7 sieves;

(4) all the other the 12 taste crude drug except Fructus Corni, Mytilus and Fructus Ligustri Lucidi are put into pot, soak 50 minutes, amount of water is 5.5 times of 12 taste crude drug gross weights, turn little fire after intense fire boils to decoct 40 minutes, leach medicinal liquid, add the water of 12 taste crude drug gross weight 4.2 times, continue decoction 40 minutes, leach medicinal liquid, merge twice medicinal liquid;

(5) by step (4) gained medicinal liquid centrifugalize 10 minutes, centrifugal speed is 4200r/min, supernatant concentration is become relative density be 1.21 clear paste, add step (1), step (2) and step (3) gained, stir, put into 60 DEG C of baking ovens dry 16 hours, take out, be ground into fine powder, cross No. 7 sieves;

(6) join in the vaseline of molten by step (5) gained, the amount of vaseline is 2.2 times of step (5) gained fine powder weight, stirs into paste, to obtain final product.

The using method that gained of the present invention treats osteoporotic externally used paste is: be spread out on cloth by products obtained therefrom of the present invention, be attached to affected part, once-a-day.

embodiment 2treat osteoporotic externally used paste, the primary raw material medicine getting following weight parts is prepared from (every part is 400g): Fructus Corni 14 parts, Radix Campanumoeae 12 parts, Rhizoma Polygonati Odorati 13 parts, PINGDIMU 10 parts, Mytilus 15 parts, Cortex Moutan 13 parts, Radix Fordiae Cauliflorae 10 parts, Herba Camptosori Sibirici 9 parts, the Radix Astragali 15 parts, Radix cynanchi wallichii 14 parts, Herba Murdanniae Divergentis 16 parts, Radix Dipsaci 15 parts, Radix grewiae bilobae 12 parts, Fructus Ligustri Lucidi 16 parts, Folium Pruni pseudocerasi 13 parts.

The preparation method of the osteoporotic externally used paste of above-mentioned treatment is:

(1) get Fructus Corni, put into 160 DEG C of hot pots, constantly stir-fry, fry 12 minutes, take out, be ground into fine powder, cross No. 7 sieves;

(2) cleaned by Mytilus, soak 4 hours with rice wine, the amount of rice wine is 4.8 times of Mytilus weight, steams 120 minutes with food steamer, takes out, dries, pulverization, crosses No. 7 sieves;

(3) get Fructus Ligustri Lucidi, clean, with vinegar, every 100g Fructus Ligustri Lucidi, with vinegar 16g, is mixed thoroughly, and moistening 4 hours, dries, pulverization, crosses No. 7 sieves;

(4) all the other the 12 taste crude drug except Fructus Corni, Mytilus and Fructus Ligustri Lucidi are put into pot, soak 50 minutes, amount of water is 8 times of 12 taste crude drug gross weights, turn little fire after intense fire boils to decoct 65 minutes, leach medicinal liquid, add the water of 12 taste crude drug gross weight 6.5 times, continue decoction 40 minutes, leach medicinal liquid, merge twice medicinal liquid;

(5) by step (4) gained medicinal liquid centrifugalize 15 minutes, centrifugal speed is 5000r/min, supernatant concentration is become relative density be 1.25 clear paste, add step (1), step (2) and step (3) gained, stir, put into 60 DEG C of baking ovens dry 16 hours, take out, be ground into fine powder, cross No. 7 sieves;

(6) join in the vaseline of molten by step (5) gained, the amount of vaseline is 3.6 times of step (5) gained fine powder weight, stirs into paste, to obtain final product.

model case one:zhao XX, man, 67 years old.Patient suffers from osteoporosis more than 10 years.Before 10 years, patient finds osteoporosis, once adopts the injection treatment such as Calcitonin, oral side Trane, without taking a turn for the better.Then to our hospital.Patient's lumbago and backache, becomes thin wan and sallow, difficulty of walking, and with forgetful, bitter taste, dormancy of receiving is poor, large dry stool, red tongue, yellow and thin fur, stringy pulse.Through X-ray examination, be diagnosed as serious osteoporosis.Use the present embodiment gained to treat osteoporotic externally used paste, products obtained therefrom of the present invention is spread out on cloth, is attached to affected part, once-a-day.Use two weeks, symptom is clearly better.Continue use 1 month, all transference cures, cure.Follow up a case by regular visits to without recurrence.

embodiment 3treat osteoporotic externally used paste, the primary raw material medicine getting following weight parts is prepared from (every part is 400g): Fructus Corni 10 parts, Radix Campanumoeae 8 parts, Rhizoma Polygonati Odorati 10 parts, PINGDIMU 7 parts, Mytilus 11 parts, Cortex Moutan 9 parts, Radix Fordiae Cauliflorae 7 parts, Herba Camptosori Sibirici 5 parts, the Radix Astragali 10 parts, Radix cynanchi wallichii 11 parts, Herba Murdanniae Divergentis 12 parts, Radix Dipsaci 9 parts, Radix grewiae bilobae 10 parts, Fructus Ligustri Lucidi 11 parts, Folium Pruni pseudocerasi 10 parts.

The preparation method of the osteoporotic externally used paste of above-mentioned treatment is:

(1) get Fructus Corni, put into 130 DEG C of hot pots, constantly stir-fry, fry 8 minutes, take out, be ground into fine powder, cross No. 7 sieves;

(2) cleaned by Mytilus, soak 3 hours with rice wine, the amount of rice wine is 3.8 times of Mytilus weight, steams 90 minutes with food steamer, takes out, dries, pulverization, crosses No. 7 sieves;

(3) get Fructus Ligustri Lucidi, clean, with vinegar, every 100g Fructus Ligustri Lucidi, with vinegar 12g, is mixed thoroughly, and moistening 3 hours, dries, pulverization, crosses No. 7 sieves;

(4) all the other the 12 taste crude drug except Fructus Corni, Mytilus and Fructus Ligustri Lucidi are put into pot, soak 50 minutes, amount of water is 5.8 times of 12 taste crude drug gross weights, turn little fire after intense fire boils to decoct 45 minutes, leach medicinal liquid, add the water of 12 taste crude drug gross weight 4.5 times, continue decoction 40 minutes, leach medicinal liquid, merge twice medicinal liquid;

(5) by step (4) gained medicinal liquid centrifugalize 11 minutes, centrifugal speed is 4500r/min, supernatant concentration is become relative density be 1.22 clear paste, add step (1), step (2) and step (3) gained, stir, put into 60 DEG C of baking ovens dry 16 hours, take out, be ground into fine powder, cross No. 7 sieves;

(6) join in the vaseline of molten by step (5) gained, the amount of vaseline is 2.5 times of step (5) gained fine powder weight, stirs into paste, to obtain final product.

model case two:wu XX, female, 55 years old.Suffer from osteoporosis more than 6 years.Before 6 years, there is lumbago and backache in patient, in local hospital inspection, is diagnosed as osteoporosis.Once accepted treatment, symptom is not felt any better all the time, and increases the weight of gradually.Under the introduction of friend, come here and go to a doctor.Patient's lumbago and backache, difficulty of walking.Dual-energy X-rays absorptionmetry checkout and diagnosis is serious osteoporosis.Use the present embodiment gained to treat osteoporotic externally used paste, products obtained therefrom of the present invention is spread out on cloth, is attached to affected part, once-a-day.After using two weeks, pain is alleviated gradually.Continue use 1 first quarter moon, transference cure, cure.Follow up a case by regular visits to without recurrence.

embodiment 4treat osteoporotic externally used paste, the primary raw material medicine getting following weight parts is prepared from (every part is 400g): Fructus Corni 13 parts, Radix Campanumoeae 11 parts, Rhizoma Polygonati Odorati 12 parts, PINGDIMU 9 parts, Mytilus 14 parts, Cortex Moutan 12 parts, Radix Fordiae Cauliflorae 9 parts, Herba Camptosori Sibirici 8 parts, the Radix Astragali 13 parts, Radix cynanchi wallichii 13 parts, Herba Murdanniae Divergentis 14 parts, Radix Dipsaci 13 parts, Radix grewiae bilobae 11 parts, Fructus Ligustri Lucidi 14 parts, Folium Pruni pseudocerasi 12 parts.

The preparation method of the osteoporotic externally used paste of above-mentioned treatment is:

(1) get Fructus Corni, put into 150 DEG C of hot pots, constantly stir-fry, fry 10 minutes, take out, be ground into fine powder, cross No. 7 sieves;

(2) cleaned by Mytilus, soak 3.5 hours with rice wine, the amount of rice wine is 4.4 times of Mytilus weight, steams 110 minutes with food steamer, takes out, dries, pulverization, crosses No. 7 sieves;

(3) get Fructus Ligustri Lucidi, clean, with vinegar, every 100g Fructus Ligustri Lucidi, with vinegar 15g, is mixed thoroughly, and moistening 3.6 hours, dries, pulverization, crosses No. 7 sieves;

(4) all the other the 12 taste crude drug except Fructus Corni, Mytilus and Fructus Ligustri Lucidi are put into pot, soak 50 minutes, amount of water is 7.4 times of 12 taste crude drug gross weights, turn little fire after intense fire boils to decoct 60 minutes, leach medicinal liquid, add the water of 12 taste crude drug gross weight 6 times, continue decoction 40 minutes, leach medicinal liquid, merge twice medicinal liquid;

(5) by step (4) gained medicinal liquid centrifugalize 13 minutes, centrifugal speed is 4800r/min, supernatant concentration is become relative density be 1.24 clear paste, add step (1), step (2) and step (3) gained, stir, put into 60 DEG C of baking ovens dry 16 hours, take out, be ground into fine powder, cross No. 7 sieves;

(6) join in the vaseline of molten by step (5) gained, the amount of vaseline is 3.2 times of step (5) gained fine powder weight, stirs into paste, to obtain final product.

model case three:liu XX, female, 48 years old.Before 2 years, the symptoms such as heel portion pain appears in patient, uncomfortable in chest, to breathe hard, to examination in hospital, examine as osteoporosis.Once take multi-medicament treatment, have no improvement.Then to our hospital.Patient's heel portion pain, uncomfortable in chest, breathe hard, myasthenia of limbs, light night in daytime is heavy, and deficiency of QI with disinclination to talk, the fat tender tongue neatly of light red tongue, slow pulse is thin.Use the present embodiment gained to treat osteoporotic externally used paste, products obtained therefrom of the present invention is spread out on cloth, is attached to affected part, once-a-day.Use 1 month, transference cure, bone density is normal, and osteoporosis disappears.Follow up a case by regular visits to without recurrence.

embodiment 5treat osteoporotic externally used paste, the primary raw material medicine getting following weight parts is prepared from (every part is 400g): Fructus Corni 11 parts, Radix Campanumoeae 10 parts, Rhizoma Polygonati Odorati 11 parts, PINGDIMU 8 parts, Mytilus 13 parts, Cortex Moutan 10 parts, Radix Fordiae Cauliflorae 8 parts, Herba Camptosori Sibirici 7 parts, the Radix Astragali 12 parts, Radix cynanchi wallichii 12 parts, Herba Murdanniae Divergentis 13 parts, Radix Dipsaci 12 parts, Radix grewiae bilobae 10.5 parts, Fructus Ligustri Lucidi 12 parts, Folium Pruni pseudocerasi 11 parts.

The preparation method of the osteoporotic externally used paste of above-mentioned treatment is:

(1) get Fructus Corni, put into 140 DEG C of hot pots, constantly stir-fry, fry 9 minutes, take out, be ground into fine powder, cross No. 7 sieves;

(2) cleaned by Mytilus, soak 3.2 hours with rice wine, the amount of rice wine is 4 times of Mytilus weight, steams 100 minutes with food steamer, takes out, dries, pulverization, crosses No. 7 sieves;

(3) get Fructus Ligustri Lucidi, clean, with vinegar, every 100g Fructus Ligustri Lucidi, with vinegar 14g, is mixed thoroughly, and moistening 3.4 hours, dries, pulverization, crosses No. 7 sieves;

(4) all the other the 12 taste crude drug except Fructus Corni, Mytilus and Fructus Ligustri Lucidi are put into pot, soak 50 minutes, amount of water is 6.6 times of 12 taste crude drug gross weights, turn little fire after intense fire boils to decoct 55 minutes, leach medicinal liquid, add the water of 12 taste crude drug gross weight 5.6 times, continue decoction 40 minutes, leach medicinal liquid, merge twice medicinal liquid;

(5) by step (4) gained medicinal liquid centrifugalize 12 minutes, centrifugal speed is 4600r/min, supernatant concentration is become relative density be 1.23 clear paste, add step (1), step (2) and step (3) gained, stir, put into 60 DEG C of baking ovens dry 16 hours, take out, be ground into fine powder, cross No. 7 sieves;

(6) join in the vaseline of molten by step (5) gained, the amount of vaseline is 2.8 times of step (5) gained fine powder weight, stirs into paste, to obtain final product.

The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:

Fructus Corni: base is former: be the sarcocarp of Cornaceae plant Fructus Corni.The property of medicine: sour, puckery, tepor.Return liver, kidney channel.Function cures mainly: liver and kidney tonifying, essence astringing and desertion stemming.For vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating is collapsed, and interior-heat is quenched one's thirst.

Radix Campanumoeae: base is former: be the root of Campanulaceae Campanumoea javanica and leopard.The property of medicine: sweet in the mouth; Property is put down.Return spleen, lung meridian.Function cures mainly: invigorating the spleen and benefiting QI; Tonifying the lung and stopping cough; Stimulating milk secretion.Main asthenia internal injury; The deficiency of vital energy is weak; Cardiopalmus; Hyperhidrosis; Diarrhea due to hypofunction of the spleen; Leucorrhea; Breast is rare; Infantile malnutrition; The enuresis; Cough due to deficiency of the lung.

Rhizoma Polygonati Odorati: base is former: be the rhizome of liliaceous plant Rhizoma Polygonati Odorati.The property of medicine: sweet, flat.Attach to the lung and stomach meridians.Function cures mainly: nourishing YIN and moistening the lung, nourishing the stomach to promote the production of body fluid.Main cough caused by dryness, chronic cough, the dry throat and mouth of calentura cloudy liquid consumption wound, interior-heat is quenched one's thirst, deficiency of YIN diseases caused by exogenous pathogenic factor, dizzy dizzy, muscle arteries and veins spasm and pain.

PINGDIMU: base is former: be the Herb of Myrsinacea plant PINGDIMU.The property of medicine: pungent; Micro-hardship; Property is put down.Return lung, Liver Channel.Function cures mainly: preventing phlegm from forming and stopping coughing, and dampness removing is invigorated blood circulation.Main new chronic cough is coughed, sputum mixed with blood, jaundice, edema, stranguria, leucorrhea, amenorrhea dysmenorrhea, rheumatic arthralgia, traumatic injury, painful and swollen testis.

Mytilus: base is former: be the meat of Mytilidae animal Mytilus crassitesta Lischke, Perna uiridis (Linnaeus) and other Mussels.The property of medicine: sweet in the mouth; Salty; Warm in nature.Return liver, kidney channel.Function cures mainly: invigorating the liver and kidney; Benefiting essence-blood; Disappear goiter.Main asthenia weakness and emaciation; Dizzy; Night sweat; Sexual impotence; Lumbago; Spit blood; Metrorrhagia; Leukorrhagia; Goiter.

Cortex Moutan: base is former: be the dry root bark of ranunculaceae peony.Composition: Cortex Moutan, containing paeonol, paeonolide, paeonolide, paeonol Neogroside, also contains paeoniflorin, oxypaeoniflorin, benzoylpaeoniflorin, benzoyl oxypaeoniflorin, gallic acid etc.In addition, still containing volatile oil, plant sterol, benzoic acid, sucrose, glucose etc.The property of medicine: bitter, pungent, is slightly cold.GUIXIN, liver, kidney channel.Function cures mainly: clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.For maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus, traumatic pain.

Radix Fordiae Cauliflorae: base is former: be root, the leaf of leguminous plant F. cauliflora Hemsl..The property of medicine: sweet; Flat; Pungent.GUIXIN, lung meridian.Function cures mainly: promoting blood circulation to remove obstruction in the collateral; Reducing swelling and alleviating pain; Preventing phlegm from forming and stopping coughing.Main air pain of dampness syndrome; Traumatic injury; Carbuncle skin ulcer swells and ache; Cough.

Herba Camptosori Sibirici: base is former: be the herb of Aspleniaceae plant walking fern.The property of medicine: light; Flat.GUIXIN warp.Function cures mainly: blood circulation promoting and blood stasis dispelling, hemostasis, removing toxic substances.Main thromboangiitis obliterans, hemiplegia, metrorrhagia, traumatic hemorrhage, neurodermatitis, ulcer of the lower limb.

The Radix Astragali: base is former: be the dry root of leguminous plant Radix Astagali or Radix Astragali.The property of medicine: sweet, temperature.Return lung, spleen channel.Function cures mainly: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst, chronic nephritis proteinuria, diabetes.

Radix cynanchi wallichii: base is former: be the root of dicotyledon medicine asclepiadaceae plant Cynanchum Wallichii.The property of medicine: sweet; Micro-hardship; Temperature.Return liver, kidney channel.Function cures mainly: invigorating the liver and kidney; Bone and muscle strengthening.Main lumbago due to renal deficiency; The foot and knee being feeble; Traumatic injury; Fracture; Lyssodexis.

Herba Murdanniae Divergentis: base is former: be root or the Herb of Commelianaceae plant purple back of the body Herba Pyrolae.The property of medicine: sweet; Micro-hardship; Flat.Function cures mainly: clearing away lung-heat to relieve cough; Invigorating the lung and the kidney; Regulating menstruation, hemostasis.Main cough due to lung-heat; The deficiency of vital energy is breathed with cough; Dizziness and tinnitus; Fracture; Spit blood.

Radix Dipsaci: base is former: be the root of Dipsacaceae plant Radix Dipsaci.The property of medicine: bitter in the mouth; Pungent; Slightly warm in nature.Return liver, kidney channel.Function cures mainly: invigorating the liver and kidney; Bone and muscle strengthening; Blood circulation regulating; Only metrorrhagia.Main aching pain in waist and back; Podomere flaccidity syndrome and arthralgia syndrome; Fall flutter wound, damage muscle folding bone, red, metrorrhagia is leaked in fetal movement, seminal emission, leukorrhagia, carbuncle skin ulcer swell.

Radix grewiae bilobae: base is former: be the Herb of Tiliaceae plant bilobed grewia.The property of medicine: sweet; Bitter; Temperature.Return liver, spleen, stomach warp.Function cures mainly: invigorating the spleen and benefiting QI; Expelling wind and removing dampness; Treating spontaneous emission and leukorrhagia.Main insufficiency of the spleen lack of appetite; Proctoptosis of a specified duration; Infantile malnutrition; Ascariasis; Rheumatic arthralgia; Seminal emission; Metrorrhagia; Leukorrhagia; Uterine prolapse.

Fructus Ligustri Lucidi: base is former: be the fruit of Oleaceae plants Fructus Ligustri Lucidi.The property of medicine: sweet, bitter, cool in nature.Return liver, kidney channel.Function cures mainly: liver and kidney tonifying, clearind deficient heat, improving eyesight.Main Light-headedness, soreness of the waist and knees, seminal emission, tinnitus, early whitening of beard and hair, osteopyrexia and fever, poor vision.

Folium Pruni pseudocerasi: base is former: be the leaf of rosaceous plant Fructus Pruni pseudocerasi.The property of medicine: sweet, bitter; Temperature; Nontoxic.Return liver, spleen, lung meridian.Function cures mainly: warming middle-JIAO and strengthening the spleen, and cough-relieving is stopped blooding, removing toxic substances parasite killing.Main cold syndrome of the stomach food stagnation; Diarrhoea; Cough; Spit blood; Skin infection swells carbuncle; Snake bite and insect sting, trichomonas vaginitis.

test example 1gained of the present invention treats the clinical practice of osteoporotic externally used paste (embodiment 5): in July ,-2012 in July, 2011, screen 330 routine sufferers of osteoporosis face in 4 hospitals, wherein male 180 example, women 150 example, age 44-70 year.Be divided into two groups at random, experimental group and matched group (often organizing 165 people).The situation no difference of science of statistics of two groups of patients in sex, age, the course of disease (P > 0.05), have good comparability.Experimental group uses products obtained therefrom of the present invention, using method: be spread out on cloth by products obtained therefrom of the present invention, be attached to affected part, once-a-day.Matched group gives BUSHEN JIANGU JIAONANG, Gusongbao Capsule, protects the Drug therapys such as capsule.Two groups of patients all treat and carry out therapeutic evaluation after two months.

Curative effect situation criterion: cure: transference cure, X-ray film shows that osteoporosis is obviously improved, and bone biochemistry is clearly better; Effective: symptom disappears substantially, X-ray film shows that osteoporosis is improved, and bone biochemistry takes a turn for the better; Take a turn for the better: symptom is improved, and X-ray film and bone biochemistry take a turn for the better to some extent; Invalid: symptom, X-ray film and bone biochemistry are all without improvement.Always effectively comprise healing, effective and improvement.

Table 1: gained of the present invention treats osteoporotic externally used paste compliance test result

efficacy analysis:as can be seen from Table 1, the cure rate using gained of the present invention to treat the experimental group of osteoporotic externally used paste is 77.58%, and total effective rate is 98.79%, and the cure rate of matched group and total effective rate are respectively 32.12% and 75.76%.Test proves, the successful of experimental group is better than matched group.

The present invention with Fructus Corni, Radix Campanumoeae, Rhizoma Polygonati Odorati pacifically wood etc. be primary raw material medicine, make treat osteoporotic externally used paste.Fructus Corni liver and kidney tonifying in side, essence astringing and desertion stemming.Radix Campanumoeae invigorating the spleen and benefiting QI; Tonifying the lung and stopping cough; Stimulating milk secretion.Rhizoma Polygonati Odorati nourishing YIN and moistening the lung, nourishing the stomach to promote the production of body fluid.PINGDIMU preventing phlegm from forming and stopping coughing, dampness removing, invigorates blood circulation.Mytilus invigorating the liver and kidney; Benefiting essence-blood; Disappear goiter.Cortex Moutan clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.Radix Fordiae Cauliflorae promoting blood circulation to remove obstruction in the collateral; Reducing swelling and alleviating pain; Preventing phlegm from forming and stopping coughing.Herba Camptosori Sibirici blood circulation promoting and blood stasis dispelling, hemostasis, removing toxic substances.Radix Astragali invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Radix cynanchi wallichii invigorating the liver and kidney; Bone and muscle strengthening.Herba Murdanniae Divergentis clearing away lung-heat to relieve cough; Invigorating the lung and the kidney; Regulating menstruation, hemostasis.Radix Dipsaci invigorating the liver and kidney; Bone and muscle strengthening; Blood circulation regulating; Only metrorrhagia.Radix grewiae bilobae invigorating the spleen and benefiting QI; Expelling wind and removing dampness; Treating spontaneous emission and leukorrhagia.Fructus Ligustri Lucidi liver and kidney tonifying, clearind deficient heat, improving eyesight.Folium Pruni pseudocerasi warming middle-JIAO and strengthening the spleen, cough-relieving is stopped blooding, removing toxic substances parasite killing.Many medicines share, mutual coordination, play effect of liver and kidney tonifying, invigorating the spleen and benefiting QI, blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, bone and muscle strengthening altogether, scalable organism endocrine, alcium and phosphor metabolization, immune system, the systems such as trace element, recover bone metabolism balance, promote the absorption of the trace element such as calcium, phosphorus and protein, vitamin D, effective raising bone mass and bone density, finally reach and cure osteoporotic object.

Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. treat osteoporotic externally used paste, it is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Fructus Corni 8-14, Radix Campanumoeae 7-12, Rhizoma Polygonati Odorati 9-13, PINGDIMU 6-10, Mytilus 9-15, Cortex Moutan 8-13, Radix Fordiae Cauliflorae 5-10, Herba Camptosori Sibirici 4-9, Radix Astragali 8-15, Radix cynanchi wallichii 9-14, Herba Murdanniae Divergentis 10-16, Radix Dipsaci 7-15, Radix grewiae bilobae 9-12, Fructus Ligustri Lucidi 8-16, Folium Pruni pseudocerasi 7-13.

2. the osteoporotic externally used paste for the treatment of as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Fructus Corni 10-13, Radix Campanumoeae 8-11, Rhizoma Polygonati Odorati 10-12, PINGDIMU 7-9, Mytilus 11-14, Cortex Moutan 9-12, Radix Fordiae Cauliflorae 7-9, Herba Camptosori Sibirici 5-8, Radix Astragali 10-13, Radix cynanchi wallichii 11-13, Herba Murdanniae Divergentis 12-14, Radix Dipsaci 9-13, Radix grewiae bilobae 10-11, Fructus Ligustri Lucidi 11-14, Folium Pruni pseudocerasi 10-12.

3. the osteoporotic externally used paste for the treatment of as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Fructus Corni 11, Radix Campanumoeae 10, Rhizoma Polygonati Odorati 11, PINGDIMU 8, Mytilus 13, Cortex Moutan 10, Radix Fordiae Cauliflorae 8, Herba Camptosori Sibirici 7, the Radix Astragali 12, Radix cynanchi wallichii 12, Herba Murdanniae Divergentis 13, Radix Dipsaci 12, Radix grewiae bilobae 10.5, Fructus Ligustri Lucidi 12, Folium Pruni pseudocerasi 11.

4. the preparation method of the osteoporotic externally used paste for the treatment of as described in as arbitrary in claims 1 to 3, it is characterized in that, step is as follows:

(1) get Fructus Corni, put into 125-160 DEG C of hot pot, constantly stir-fry, fry 7-12 minute, take out, be ground into fine powder, cross No. 7 sieves;

(2) cleaned by Mytilus, soak 2.5-4 hour with rice wine, the amount of rice wine is 3.5-4.8 times of Mytilus weight, steams 85-120 minute with food steamer, takes out, dries, pulverization, cross No. 7 sieves;

(3) get Fructus Ligustri Lucidi, clean, with vinegar, every 100g Fructus Ligustri Lucidi, with vinegar 10-16g, is mixed thoroughly, moistening 2.5-4 hour (preferred, moistening 3-3.6 hour; Be more preferably, moistening 3.4 hours), dry, pulverization, cross No. 7 sieves;

(4) all the other the 12 taste crude drug except Fructus Corni, Mytilus and Fructus Ligustri Lucidi are put into pot, soak 50 minutes, amount of water is that doubly (preferred, amount of water is 5.8-7.4 times of 12 taste crude drug gross weights to the 5.5-8 of 12 taste crude drug gross weights; Be more preferably, amount of water is 6.6 times of 12 taste crude drug gross weights), (preferably, intense fire turns little fire decoction 45-60 minute after boiling to turn little fire decoction 40-65 minute after intense fire boils; Be more preferably, intense fire boils rear turn of little fire and decocts 55 minutes), leach medicinal liquid, add 12 taste crude drug gross weight 4.2-6.5 water doubly and (preferably, add the water of 12 taste crude drug gross weight 4.5-6 times; Be more preferably, add the water of 12 taste crude drug gross weight 5.6 times), continue decoction 40 minutes, leach medicinal liquid, merge twice medicinal liquid;

(5) by step (4) gained medicinal liquid centrifugalize 10-15 minute (preferred, by step (4) gained medicinal liquid centrifugalize 11-13 minute; Be more preferably, by step (4) gained medicinal liquid centrifugalize 12 minutes), centrifugal speed is that 4200-5000r/min(is preferred, and centrifugal speed is 4500-4800r/min; Be more preferably, centrifugal speed is 4600r/min), supernatant concentration is become relative density be 1.21-1.25 clear paste (preferred, supernatant concentration become relative density to be the clear paste of 1.22-1.24; Be more preferably, supernatant concentration is become relative density be 1.23 clear paste), add step (1), step (2) and step (3) gained, stir, put into 60 DEG C of baking ovens dry 16 hours, take out, be ground into fine powder, cross No. 7 sieves;

(6) join in the vaseline of molten by step (5) gained, the amount of vaseline is that doubly (preferred, the amount of vaseline is 2.5-3.2 times of step (5) gained fine powder weight to the 2.2-3.6 of step (5) gained fine powder weight; Be more preferably, the amount of vaseline is 2.8 times of step (5) gained fine powder weight), stir into paste, to obtain final product.

5. the preparation method of the osteoporotic externally used paste for the treatment of as claimed in claim 4, is characterized in that, put into 130-150 DEG C of hot pot (preferably putting into 140 DEG C of hot pots) in step (1).

6. the preparation method of the osteoporotic externally used paste for the treatment of as claimed in claim 4, is characterized in that, fries 8-10 minute (preferably frying 9 minutes) in step (1).

7. the preparation method of the osteoporotic externally used paste for the treatment of as claimed in claim 4, is characterized in that, soaks 3-3.5 hour (preferably soaking 3.2 hours with rice wine) in step (2) with rice wine.

8. the preparation method of the osteoporotic externally used paste for the treatment of as claimed in claim 4, is characterized in that, in step (2), the amount of rice wine is 3.8-4.4 times (amount of preferred rice wine is 4 times of Mytilus weight) of Mytilus weight.

9. the preparation method of the osteoporotic externally used paste for the treatment of as claimed in claim 4, is characterized in that, steams 90-110 minute (preferably steaming 100 minutes with food steamer) in step (2) with food steamer.

10. the preparation method of the osteoporotic externally used paste for the treatment of as claimed in claim 4, is characterized in that, in step (3) every 100g Fructus Ligustri Lucidi with vinegar 12-15g(preferably often 100g Fructus Ligustri Lucidi with vinegar 14g).