CN105193960A - Traditional Chinese medicine composition for treating traumatic injury and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating traumatic injury and preparation method and application thereof Download PDFInfo
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- CN105193960A CN105193960A CN201510712111.XA CN201510712111A CN105193960A CN 105193960 A CN105193960 A CN 105193960A CN 201510712111 A CN201510712111 A CN 201510712111A CN 105193960 A CN105193960 A CN 105193960A
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Abstract
The invention discloses a traditional Chinese medicine composition for treating traumatic injury and a preparation method and an application thereof. The traditional Chinese medicine composition comprises 12-30 parts by mass of horseweed herb, 6-13 parts by mass of commelina diffusa and 8-22 parts by mass of polygonum cuspidatum. The preparation method comprises the steps: washing horseweed herb and commelina diffusa cleanly, adding water, soaking, carrying out heating extraction for three times, merging the three extract liquids, filtering to obtain a filtrate, and concentrating to a thick paste having the relative density of 1.12-1.14 at the temperature of 65 DEG C; crushing polygonum cuspidatum with an ethanol solution for 3 times firstly, then carrying out crushing extraction with hot water for 3 times, merging the extract liquids to obtain a polygonum cuspidatum effective ingredient; adding the extracted polygonum cuspidatum effective ingredient into the thick paste, mixing evenly, and thus obtaining the traditional Chinese medicine preparation for treating traumatic injury. The traditional Chinese medicine composition has the efficacies of promoting blood circulation dredging collaterals, dispersing blood stasis and relieving pain, and diminishing inflammation and detoxifying, has the treatment effective rate on acute closed soft tissue injury in traumatic injury of more than or equal to 90%, and has the advantages of significant and reliable curative effect, quick effect, convenient taking and the like.
Description
Technical field
The present invention relates to technical field of Chinese medicines, specifically a kind of Chinese medicine composition for the treatment of traumatic injury and preparation method thereof and purposes.
Background technology
People are in routine work and life, especially when ascend a height in out on tours or open air, traumatic injury, to damage, abrading the traumatic injury such as hemorrhage, congestion is livid purple is common occurrence, traumatic injury also comprises weapons, tumbling down, hits, sprain and contusion, stab, abrade, athletic injury, acute and closed soft tissue injury etc., there are pain, swelling, hemorrhage or fracture, dislocation etc. in injury more, also comprises some visceral injuries.
At present, treatment traumatic injury, the means such as the multiplex drug of topical application, massage, treatment cycle is long, and permanent medical expenses are propped up and sold Most patients and be difficult to bear.
Herba Clinopodii Polycephali, another name Herba Eguiseti Debilis, lock eyebrow grass, penholder are careless, and be the herb of Equisetaceae horse-tail Herba Clinopodii Polycephali, property is put down, and sweet in the mouth, micro-hardship, have effect of heat clearing away, diuresis, improving acuity of vision and removing nebula, expelling phlegm for arresting cough.
Summary of the invention
The object of the present invention is to provide Chinese medicine composition of a kind of evident in efficacy, treatment traumatic injury that treatment cycle is short and preparation method thereof and purposes.
For achieving the above object, the invention provides following technical scheme:
Treat a Chinese medicine composition for traumatic injury, according to mass fraction, be made up of Conyza canadensis (L.) Cronq. 12 ~ 30 parts, Herba Clinopodii Polycephali 6 ~ 13 parts and Rhizoma Polygoni Cuspidati 8 ~ 22 parts.
As the further scheme of the present invention: according to mass fraction, be made up of Conyza canadensis (L.) Cronq. 16 ~ 25 parts, Herba Clinopodii Polycephali 6 ~ 10 parts and Rhizoma Polygoni Cuspidati 10 ~ 18 parts.
As the further scheme of the present invention: according to mass fraction, be made up of Conyza canadensis (L.) Cronq. 22 parts, Herba Clinopodii Polycephali 8 parts and Rhizoma Polygoni Cuspidati 14 parts.
The preparation method of the Chinese medicine composition of described treatment traumatic injury, comprises the following steps:
(1) Conyza canadensis (L.) Cronq. and Herba Clinopodii Polycephali are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 4 ~ 5 hours, boil 3 ~ 4 hours, extract; Again add the distilled water of 6 ~ 8 times amount, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter to get filtrate, gained filtrate being condensed into relative density at 65 DEG C is the thick paste of 1.12 ~ 1.14, for subsequent use;
(2) adopt waterproof pulverization to extract separately Rhizoma Polygoni Cuspidati, first pulverize 3 times, 10min/ time with the alcoholic solution that the volumetric concentration of 5 times amount is 60%; Medicinal residues after extraction pulverize extraction 3 times, 10min/ time with the hot water of 10 times amount again; Merge two kinds of extracts and obtain Rhizoma Polygoni Cuspidati effective ingredient;
(3) joined by the Rhizoma Polygoni Cuspidati effective ingredient that step (2) is extracted in thick paste prepared by step (1), mix homogeneously, obtains the Chinese medicine preparation of described treatment traumatic injury.
The purposes of described Chinese medicine composition in preparation treatment traumatic injury medicine.
The using method of the Chinese medicine composition of described treatment traumatic injury: for oral administration, every day potion, point early, evening takes for twice, each serving with the medicament being equivalent to 20g crude drug amount.
Compared with prior art, the invention has the beneficial effects as follows:
The simple science of formula of the present invention, all adopts common Chinese crude drug, has the advantage that medicine source is wide, cost is low; The present invention is based on the Conyza canadensis (L.) Cronq. of clearing away heat-damp and promoting diuresis, dissipating blood stasis for subsidence of swelling, be auxiliary with the Herba Clinopodii Polycephali of the Rhizoma Polygoni Cuspidati of expelling wind and removing dampness, dissipating blood stasis analgesic therapy and clearing away heat and promoting diuresis, antiinflammatory, play effect of promoting blood circulation to remove obstruction in the collateral, eliminating stasis to stop pain, eliminating inflammation and expelling toxin, treated effect for the acute and closed soft tissue injury in traumatic injury reaches more than 90%, and the present invention has the advantages such as reliable, instant effect, taking convenience evident in efficacy.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1
In the embodiment of the present invention, a kind of Chinese medicine composition for the treatment of traumatic injury, according to mass fraction, is made up of Conyza canadensis (L.) Cronq. 30 parts, Herba Clinopodii Polycephali 6 parts and Rhizoma Polygoni Cuspidati 8 parts.
The preparation method of the Chinese medicine composition of described treatment traumatic injury, comprises the following steps:
(1) Conyza canadensis (L.) Cronq. and Herba Clinopodii Polycephali are cleaned, put into container, add the distilled water of 10 times amount, soak after 5 hours, boil 4 hours, extract; Again add the distilled water of 8 times amount, boil 3 hours, extract; Finally, add 6 times amount distilled water, heated and boiled 2 hours, extract; Merge three extracting solution, filter to get filtrate, gained filtrate being condensed into relative density at 65 DEG C is the thick paste of 1.12, for subsequent use;
(2) adopt waterproof pulverization to extract separately Rhizoma Polygoni Cuspidati, first pulverize 3 times, 10min/ time with the alcoholic solution that the volumetric concentration of 5 times amount is 60%; Medicinal residues after extraction pulverize extraction 3 times, 10min/ time with the hot water of 10 times amount again; Merge two kinds of extracts and obtain Rhizoma Polygoni Cuspidati effective ingredient;
(3) joined by the Rhizoma Polygoni Cuspidati effective ingredient that step (2) is extracted in thick paste prepared by step (1), mix homogeneously, obtains the Chinese medicine preparation of described treatment traumatic injury.
Embodiment 2
In the embodiment of the present invention, a kind of Chinese medicine composition for the treatment of traumatic injury, according to mass fraction, is made up of Conyza canadensis (L.) Cronq. 18 parts, Herba Clinopodii Polycephali 8 parts and Rhizoma Polygoni Cuspidati 16 parts.
The preparation method of the Chinese medicine composition of described treatment traumatic injury, comprises the following steps:
(1) Conyza canadensis (L.) Cronq. and Herba Clinopodii Polycephali are cleaned, put into container, add the distilled water of 8 times amount, soak after 4 hours, boil 3 hours, extract; Again add the distilled water of 6 times amount, boil 2 hours, extract; Finally, add 4 times amount distilled water, heated and boiled 1 hour, extract; Merge three extracting solution, filter to get filtrate, gained filtrate being condensed into relative density at 65 DEG C is the thick paste of 1.14, for subsequent use;
(2) adopt waterproof pulverization to extract separately Rhizoma Polygoni Cuspidati, first pulverize 3 times, 10min/ time with the alcoholic solution that the volumetric concentration of 5 times amount is 60%; Medicinal residues after extraction pulverize extraction 3 times, 10min/ time with the hot water of 10 times amount again; Merge two kinds of extracts and obtain Rhizoma Polygoni Cuspidati effective ingredient;
(3) joined by the Rhizoma Polygoni Cuspidati effective ingredient that step (2) is extracted in thick paste prepared by step (1), mix homogeneously, obtains the Chinese medicine preparation of described treatment traumatic injury.
Embodiment 3
In the embodiment of the present invention, a kind of Chinese medicine composition for the treatment of traumatic injury, according to mass fraction, is made up of Conyza canadensis (L.) Cronq. 22 parts, Herba Clinopodii Polycephali 8 parts and Rhizoma Polygoni Cuspidati 14 parts.
The preparation method of the Chinese medicine composition of described treatment traumatic injury, comprises the following steps:
(1) Conyza canadensis (L.) Cronq. and Herba Clinopodii Polycephali are cleaned, put into container, add the distilled water of 9 times amount, soak after 5 hours, boil 4 hours, extract; Again add the distilled water of 7 times amount, boil 3 hours, extract; Finally, add 4 times amount distilled water, heated and boiled 1 hour, extract; Merge three extracting solution, filter to get filtrate, gained filtrate being condensed into relative density at 65 DEG C is the thick paste of 1.14, for subsequent use;
(2) adopt waterproof pulverization to extract separately Rhizoma Polygoni Cuspidati, first pulverize 3 times, 10min/ time with the alcoholic solution that the volumetric concentration of 5 times amount is 60%; Medicinal residues after extraction pulverize extraction 3 times, 10min/ time with the hot water of 10 times amount again; Merge two kinds of extracts and obtain Rhizoma Polygoni Cuspidati effective ingredient;
(3) joined by the Rhizoma Polygoni Cuspidati effective ingredient that step (2) is extracted in thick paste prepared by step (1), mix homogeneously, obtains the Chinese medicine preparation of described treatment traumatic injury.
Embodiment 4
In the embodiment of the present invention, a kind of Chinese medicine composition for the treatment of traumatic injury, according to mass fraction, is made up of Conyza canadensis (L.) Cronq. 26 parts, Herba Clinopodii Polycephali 7 parts and Rhizoma Polygoni Cuspidati 10 parts.
The preparation method of the Chinese medicine composition of described treatment traumatic injury, comprises the following steps:
(1) Conyza canadensis (L.) Cronq. and Herba Clinopodii Polycephali are cleaned, put into container, add the distilled water of 10 times amount, soak after 4 hours, boil 4 hours, extract; Again add the distilled water of 6 times amount, boil 3 hours, extract; Finally, add 4 times amount distilled water, heated and boiled 1 hour, extract; Merge three extracting solution, filter to get filtrate, gained filtrate being condensed into relative density at 65 DEG C is the thick paste of 1.14, for subsequent use;
(2) adopt waterproof pulverization to extract separately Rhizoma Polygoni Cuspidati, first pulverize 3 times, 10min/ time with the alcoholic solution that the volumetric concentration of 5 times amount is 60%; Medicinal residues after extraction pulverize extraction 3 times, 10min/ time with the hot water of 10 times amount again; Merge two kinds of extracts and obtain Rhizoma Polygoni Cuspidati effective ingredient;
(3) joined by the Rhizoma Polygoni Cuspidati effective ingredient that step (2) is extracted in thick paste prepared by step (1), mix homogeneously, obtains the Chinese medicine preparation of described treatment traumatic injury.
Embodiment 5
In the embodiment of the present invention, a kind of Chinese medicine composition for the treatment of traumatic injury, according to mass fraction, is made up of Conyza canadensis (L.) Cronq. 12 parts, Herba Clinopodii Polycephali 13 parts and Rhizoma Polygoni Cuspidati 22 parts.
The preparation method of the Chinese medicine composition of described treatment traumatic injury, comprises the following steps:
(1) Conyza canadensis (L.) Cronq. and Herba Clinopodii Polycephali are cleaned, put into container, add the distilled water of 8 times amount, soak after 5 hours, boil 4 hours, extract; Again add the distilled water of 6 times amount, boil 2 hours, extract; Finally, add 6 times amount distilled water, heated and boiled 2 hours, extract; Merge three extracting solution, filter to get filtrate, gained filtrate being condensed into relative density at 65 DEG C is the thick paste of 1.12, for subsequent use;
(2) adopt waterproof pulverization to extract separately Rhizoma Polygoni Cuspidati, first pulverize 3 times, 10min/ time with the alcoholic solution that the volumetric concentration of 5 times amount is 60%; Medicinal residues after extraction pulverize extraction 3 times, 10min/ time with the hot water of 10 times amount again; Merge two kinds of extracts and obtain Rhizoma Polygoni Cuspidati effective ingredient;
(3) joined by the Rhizoma Polygoni Cuspidati effective ingredient that step (2) is extracted in thick paste prepared by step (1), mix homogeneously, obtains the Chinese medicine preparation of described treatment traumatic injury.
Below for Chinese medicine composition of the present invention is applied to the clinical treatment data of traumatic injury
Clinical data
1, physical data
Acute and closed soft tissue injury belongs to the one of traumatic injury.Select acute and closed soft tissue injury patient 280 example made a definite diagnosis through hospital, wherein male 152 example, women 128 example, 5 ~ 65 years old age, 56 years old mean age.This 350 routine patient is divided into seven groups at random, is respectively treatment 1 ~ 5 group, contrast 1 ~ 2 group, often organize 40 examples, the sex between each group, age and course of disease length there was no significant difference, have comparability.
2, diagnostic criteria
Diagnostic criteria is with reference to the diagnosis and by stages of the acute injury of tendon and muscle in " injury of tendon and muscle ":
(1) early stage: injured 1 ~ 3 day, now because blood vessels are impaired, blood was from channel tunnel, and congestion stops gathering, injury obvious tumefaction, violent twinge, and sore spot is fixing does not move; The visible Tension Vesicle of serious swelling person.Disorder of limb ' s activity.
(2) mid-term: injured 4 ~ 14 days, this phase pain relief, congestion gradually fall apart, and swelling starts to go down, visible livid purple ecchymosis.
(3) in the later stage: the serious symptom injury of tendon and muscle 2 ~ 5 weeks, serious symptom injury of tendon and muscle symptom after controlling two weeks disappears substantially, and pain is gradually not obvious, and function can have slight obstacle, this kind of Remnant symptome, and about through 2 ~ 5 weeks, can all disappear, merit also can be recovered; If but with nerve injury or remaining swollen remaining, scleroma as block, pain indistinctly, delay with the passing of time, finally may become Chronic soft tissue injury.
3, Therapeutic Method
Treat 1 ~ 5 group and take the obtained Chinese medicine composition of embodiment 1 ~ 5 respectively, potion, divided early, evening took for twice, each serving with the dosage being equivalent to 20g crude drug amount, within 10 days, is a course for the treatment of, uses 3 courses for the treatment of continuously every day.
Contrast 1 group of Chinese medicine composition taken only containing Radix Musae and the Cortex Eucommiae, all the other conditions are consistent with embodiment 3.Every day, potion, point sooner or later took for twice, each serving with the dosage being equivalent to 20g crude drug amount, within 10 days, was a course for the treatment of, used 3 courses for the treatment of continuously.
Contrast 2 groups of Chinese medicine compositions taken only containing Semen Nelumbinis, all the other conditions are consistent with embodiment 3.Every day, potion, point sooner or later took for twice, each serving with the dosage being equivalent to 20g crude drug amount, within 10 days, was a course for the treatment of, used 3 courses for the treatment of continuously.
Treatments period, does not re-use other Drug therapy.
4, curative effect determinate standard
Recovery from illness: swelling pain disappears completely, limbs recover normal function.
Effective: injury swelling pain disappears, after aggravating activities, micro-sense is uncomfortable.
Take a turn for the better: injury or neighbouring function of joint are normal, but after aggravating activities, there are slight swelling or pain in affected part.
Invalid: during rest, the micro-sense of affected part is uncomfortable, and mild swelling, long-time aggravating activities or unrestrained the swelling in rear affected part of bearing a heavy burden do not disappear, and have more serious pain uncomfortable.
Cure, effective and take a turn for the better all count effective statistics.
5, result of the test
The therapeutic outcome that table 1 is respectively organized
Group | Case load | Cure number | Effective number | Good revolution | Invalid number | Cure rate | Total effective rate |
Treat 1 group | 40 | 25 | 5 | 7 | 3 | 62.5% | 92.5% |
Treat 2 groups | 40 | 28 | 4 | 5 | 3 | 70% | 92.5% |
Treat 3 groups | 40 | 29 | 6 | 3 | 2 | 72.5% | 95.0% |
Treat 4 groups | 40 | 29 | 5 | 3 | 3 | 72.5% | 92.5% |
Treat 5 groups | 40 | 24 | 4 | 8 | 4 | 60% | 90% |
Contrast 1 group | 40 | 4 | 6 | 9 | 21 | 10% | 47.5% |
Contrast 2 groups | 40 | 0 | 3 | 4 | 33 | 0% | 17.5% |
Through the treatment time of three courses for the treatment of, final therapeutic outcome as shown in Table 1, as can be seen from table: adopt traditional Chinese medicine composition for treating traumatic injury of the present invention, after using 3 courses for the treatment of, cure rate is 60 ~ 72.5%, total effective rate reaches more than 90%, thus Chinese medicine composition of the present invention has good therapeutic effect for the acute and closed soft tissue injury in traumatic injury, wherein embodiment 3 is optimum embodiment of the present invention, after using 3 courses for the treatment of, cure rate reaches 72.5%, and total effective rate reaches 95%.Especially, in clinical observation process, whole seven groups all there is not obvious side effect, illustrate that Chinese medicine composition of the present invention has no side effect safely.
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and when not deviating from spirit of the present invention or basic feature, the present invention can be realized in other specific forms.Therefore, no matter from which point, all should embodiment be regarded as exemplary, and be nonrestrictive, scope of the present invention is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalency by dropping on claim and scope are included in the present invention.
In addition, be to be understood that, although this description is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, and the technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.
Claims (5)
1. treat a Chinese medicine composition for traumatic injury, it is characterized in that, according to mass fraction, be made up of Conyza canadensis (L.) Cronq. 12 ~ 30 parts, Herba Clinopodii Polycephali 6 ~ 13 parts and Rhizoma Polygoni Cuspidati 8 ~ 22 parts.
2. the Chinese medicine composition for the treatment of traumatic injury according to claim 1, is characterized in that, according to mass fraction, is made up of Conyza canadensis (L.) Cronq. 16 ~ 25 parts, Herba Clinopodii Polycephali 6 ~ 10 parts and Rhizoma Polygoni Cuspidati 10 ~ 18 parts.
3. the Chinese medicine composition for the treatment of traumatic injury according to claim 1, is characterized in that, according to mass fraction, is made up of Conyza canadensis (L.) Cronq. 22 parts, Herba Clinopodii Polycephali 8 parts and Rhizoma Polygoni Cuspidati 14 parts.
4. a preparation method for the Chinese medicine composition of the treatment traumatic injury as described in as arbitrary in claims 1 to 3, is characterized in that, comprise the following steps:
(1) Conyza canadensis (L.) Cronq. and Herba Clinopodii Polycephali are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 4 ~ 5 hours, boil 3 ~ 4 hours, extract; Again add the distilled water of 6 ~ 8 times amount, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter to get filtrate, gained filtrate being condensed into relative density at 65 DEG C is the thick paste of 1.12 ~ 1.14, for subsequent use;
(2) adopt waterproof pulverization to extract separately Rhizoma Polygoni Cuspidati, first pulverize 3 times, 10min/ time with the alcoholic solution that the volumetric concentration of 5 times amount is 60%; Medicinal residues after extraction pulverize extraction 3 times, 10min/ time with the hot water of 10 times amount again; Merge two kinds of extracts and obtain Rhizoma Polygoni Cuspidati effective ingredient;
(3) joined by the Rhizoma Polygoni Cuspidati effective ingredient that step (2) is extracted in thick paste prepared by step (1), mix homogeneously, obtains the Chinese medicine preparation of described treatment traumatic injury.
5. the purposes of the Chinese medicine composition as described in as arbitrary in claims 1 to 3 in preparation treatment traumatic injury medicine.
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Cited By (1)
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CN114504624A (en) * | 2022-04-19 | 2022-05-17 | 深圳德荫堂生物科技有限公司 | Eyesight-improving eye-protecting medicine and production method thereof |
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CN1435219A (en) * | 2002-11-26 | 2003-08-13 | 贵州神奇制药有限公司 | Medicine for treating traumatic injury |
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CN114504624A (en) * | 2022-04-19 | 2022-05-17 | 深圳德荫堂生物科技有限公司 | Eyesight-improving eye-protecting medicine and production method thereof |
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