CN105191934B - Thimerosal, non-woven fabrics containing thimerosal and its preparation method and application - Google Patents
Thimerosal, non-woven fabrics containing thimerosal and its preparation method and application Download PDFInfo
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- CN105191934B CN105191934B CN201510570112.5A CN201510570112A CN105191934B CN 105191934 B CN105191934 B CN 105191934B CN 201510570112 A CN201510570112 A CN 201510570112A CN 105191934 B CN105191934 B CN 105191934B
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- woven fabrics
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Abstract
A kind of thimerosal, the gross weight by the thimerosal based on 100wt.%, including：0.1 1wt.% quaternary ammonium salt；0.01 1wt.% caprylates；0.01 1wt.% oxidizing alcohol SYNPERONIC PE/F68；37 99.88wt.% water；With 0 60wt.% alcohol.There is good sterilizing ability according to the thimerosal of the disclosure, relatively low to metal protection, rate of drying is very fast after wiping body surface, and preferable compatibility is furnished with nonwoven.
Description
Technical field
This disclosure relates to field is cleaned and sterilizes, more particularly to a kind of thimerosal, the non-woven fabrics containing thimerosal and its preparation
Methods and applications.
Background technology
In recent years, increasing research showed, cleaning and the Disinfection Effect and the generation of hospital infection event of hospital
It is relevant.
At present, there are two kinds of traditional surface cleaning sterilization methods in Chinese medical field, one kind is matched somebody with somebody using towel
Chlorine-containing agent is closed, another kind is the method that towel coordinates alcohol disinfectant.Above two method be required for spending many manpowers with
Time configures sterilised liq and cleaning towel, also, if the configuration of disinfectant is inaccurate or the processing of towel is not thorough, all
Disinfection Effect may be influenceed, or even causes cross pollution.In addition, the smell of chlorine-containing agent is big to human body excitant, while its
Chemical composition may cause to corrode to body surface.A kind of new it is used for surface of objects in hospital by cleanness therefore, it is necessary to develop
With the thimerosal of sterilization and the non-woven fabrics containing thimerosal.
The content of the invention
For above-mentioned problems of the prior art, the disclosure aims to provide a kind of new thimerosal, and the thimerosal should
At least have good bactericidal property, body surface drying time it is shorter, it is smaller to the corrosivity of metal surface and with
Nonwoven is furnished with preferable compatibility.
Some aspects of the disclosure provide a kind of thimerosal, the gross weight by the thimerosal based on 100wt.%, including：
0.1-1wt.% quaternary ammonium salt；0.01-1wt.% caprylates；0.01-1wt.% oxidizing alcohol oxirane
Epoxy propane copolymer；37-99.88wt.% water；With 0-60wt.% alcohol.
Some aspects of the disclosure provide a kind of method for preparing the thimerosal, including step：By described thimerosal
Each composition mixing.
Some aspects of the disclosure provide a kind of non-woven fabrics containing thimerosal, including：Non-woven fabrics and it is dispersed in the nonwoven
Thimerosal according to the present disclosure in cloth；Wherein, the gross weight by the non-woven fabrics is based on 100wt.%, the non-woven fabrics
Including：0-50wt.% viscose rayon and 50-100wt.% polyester fiber；The weight of the thimerosal and the non-woven fabrics
Than for 3:1-6:1.
Some aspects of the disclosure provide a kind of method for preparing the non-woven fabrics containing thimerosal, including step, will be according to this
Thimerosal described in open is distributed in non-woven fabrics, wherein, the gross weight by the non-woven fabrics is based on 100wt.%, the nothing
Spinning cloth includes：0-50wt.% viscose rayon and 50-100wt.% polyester fiber；The thimerosal and the non-woven fabrics
Weight ratio is 3:1-6:1.
Some aspects of the disclosure provide a kind of non-woven fabrics according to the present disclosure containing thimerosal and disappeared in medical cleaning
Application in poison.
Escherichia coli, staphylococcus aureus, P. aeruginosa can quickly, efficiently be killed according to the thimerosal of the disclosure
The common germ of the hospitals such as bacterium, Candida albicans.Meanwhile the thimerosal of the disclosure is very low to metal protection, durability is strong, wipes
Rate of drying is very fast behind surface, preferable with the compatibility of non-woven fabrics, suitable for the cleaning and sterilization of Pangquangou Natural Reserve.
Embodiment
It should be appreciated that in the case where not departing from the scope of the present disclosure or spirit, those skilled in the art can be according to this
The teaching of specification contemplates other various embodiments and it can be modified.Therefore, following embodiment is not
Restrictive meaning.
Except as otherwise noted, expression characteristic size, quantity and the materialization otherwise used in specification and claims is special
All numerals of property are construed as being modified by term " about " in all cases.Therefore, unless there are opposite
Illustrate, the numerical parameter otherwise listed in description above and appended claims is approximation, those skilled in the art
Member can utilize teachings disclosed herein to seek the required characteristic obtained, suitably change these approximations.With end points table
The use for the number range shown includes all numerals in the range of this and any scope in the range of this, for example, 1 to 5 includes
1st, 1.1,1.3,1.5,2,2.75,3,3.80,4 and 5 etc..
Thimerosal
Some aspects of the disclosure provide a kind of thimerosal, the gross weight by the thimerosal based on 100wt.%, including：
0.1-1wt.% quaternary ammonium salt；0.01-1wt.% caprylates；0.01-1wt.% oxidizing alcohol oxirane
Epoxy propane copolymer；37-99.88wt.% water；With 0-60wt.% alcohol.
Quaternary ammonium salt
In the thimerosal according to the disclosure, the quaternary ammonium salt has good sterilization effect, to common microbiological
As staphylococcus aureus, Escherichia coli, pseudomonas aeruginosa and Candida albicans have significant killing effect.
According to some embodiments, based on 100wt.%, quaternary ammonium salt includes the gross weight by the thimerosal：
0.05-0.95wt.% single-stranded quaternary ammonium salt；(ii) 0.05-0.95wt.% double-chain quaternary ammonium salt.
According to some embodiments, the single-stranded quaternary ammonium salt includes at least one of following group composition：C12-C18
Zephiran, C12-C18 Alkyl dimethyl benzyl ammonium bromides, C12-C18 alkyl trimethyl benzyl ammonium chlorides
With C12-C18 alkyl trimethyl Benzylphosphonium Bromide ammoniums.
According to some embodiments, the double-chain quaternary ammonium salt includes at least one of following group composition：C8-C18
The double alkyl dimethyl ammonium bromides of Dialkyl dimethyl ammonium chloride, C8-C18.
According to some embodiments, the quaternary ammonium salt can select the Bardac 208M purchased from Lonza companies.
For gross weight by the thimerosal based on 100wt.%, the content of the quaternary ammonium salt is 0.1-1wt.%.When described
When the content of quaternary ammonium salt is more than 0.1wt.%, thimerosal can be made to have preferable bactericidal effect；
When the content of the quaternary ammonium salt is less than 1wt.%, thimerosal will not produce pungent smell, will not stimulate human body
Respiratory tract.
Caprylates
In the thimerosal disclosed in, the caprylates can significantly reduce the surface tension of thimerosal, promote
The drying time entered after wiping, strengthen sterilizing ability.
According to some embodiments, the caprylates include at least one of following group composition：Mountain
The smooth caprylate of pears, the smooth oleate of sorb, the smooth stearate of sorb and sorbitan monopalmitate.
According to some embodiments, the smooth caprylate of sorb can be selected purchased from Croda companies
NatraSense LF8。
According to some embodiments, the smooth oleate of sorb can be purchased from Wuhan far into creating the limited public affairs of science and technology
Department.
According to some embodiments, it is limited that the smooth stearate of sorb can be purchased from daylight chemistry trade (Shanghai)
Company.
According to some embodiments, the sorbitan monopalmitate, which can be purchased from daylight chemistry trade (Shanghai), to be had
Limit company.
For gross weight by the thimerosal based on 100wt.%, the content of the caprylates is 0.01-
1wt.%.When the content of the caprylates is 0.01-1wt.%, thimerosal can be made in the drying of body surface
Between it is shorter, and further enhance sterilizing ability.
Oxidizing alcohol SYNPERONIC PE/F68
In the thimerosal disclosed in, the oxidizing alcohol SYNPERONIC PE/F68 can be reduced to metal
Corrosivity, promote bactericidal property.
According to some embodiments, the carbon number of the oxidizing alcohol SYNPERONIC PE/F68 is
12-15。
According to some embodiments, the oxidizing alcohol SYNPERONIC PE/F68 can be selected and is purchased from
The GenapolEP 2584 of Clarient companies.
Gross weight by the thimerosal based on 100wt.%, the oxidizing alcohol SYNPERONIC PE/F68
Content is 0.01-1wt.%.When the content of the oxidizing alcohol SYNPERONIC PE/F68 is 0.01-1wt.%,
Non-woven fabrics containing thimerosal will not leave behind excessive foam after body surface is wiped across.
Water
In the thimerosal disclosed in, the water is the solvent in the thimerosal.
For gross weight by the thimerosal based on 100wt.%, the content of the water is 37-99.88wt.%.When the water
Content when being 37-99.88wt.%, each composition in thimerosal can dissolve fully.
Alcohol
In the thimerosal disclosed in, the alcohol can further promote rapid draing and bactericidal effect.
According to some embodiments, the alcohol includes at least one of following group composition：Ethanol and isopropanol.
According to some embodiments, the ethanol can be purchased from Chemical Reagent Co., Ltd., Sinopharm Group.
According to some embodiments, the isopropanol can be purchased from Chemical Reagent Co., Ltd., Sinopharm Group
For gross weight by the thimerosal based on 100wt.%, the content of the alcohol is 0-60wt.%.
Erosion resistant agent
According to the thimerosal of the disclosure, the gross weight by the thimerosal can also include 0.1- based on 100wt.%
0.5wt.% erosion resistant agent.
In the thimerosal according to the disclosure, the erosion resistant agent can further suppress to corrosion of metal.
According to some embodiments, the erosion resistant agent can select known those applicable erosion resistant agent.According to some
Embodiment, the erosion resistant agent include at least one of following group composition：Chromate, nitrite, silicate, molybdic acid
Salt, tungstates, Quadrafos and zinc salt.
According to some embodiments, the chromate can be selected and be purchased from the limited public affairs of Shanghai Shantou brilliance chemical reagent
The sodium chromate of department.
According to some embodiments, the nitrite can be selected limited purchased from Shanghai Shantou brilliance chemical reagent
The natrium nitrosum of company.
The method for preparing thimerosal
Some aspects of the disclosure provide a kind of method for preparing thimerosal, including step：By the sterilization according to the disclosure
Each composition mixing of liquid.
According to some embodiments, the method for preparing thimerosal, pressed with the gross weight of the thimerosal
100wt.% is counted, including step：0.1-1wt.% quaternary ammonium salt is added in 5-20wt.% water, to obtain the first solution；
0.01-1.0wt.% caprylates are added in first solution, to obtain the second solution；5- is added in the second solution
The alcohol of 20wt.% water, 0.01-1.0wt.% oxidizing alcohols SYNPERONIC PE/F68 and 0-60wt.%, polishing water
To 100wt.%, with the liquid that is sterilized.
According to some embodiments, the method for preparing thimerosal, pressed with the gross weight of the thimerosal
100wt.% is counted, including step：0.1-1wt.% quaternary ammonium salt is added in 5-20wt.% water, to obtain the first solution；
0.01-1.0wt.% caprylates are added in first solution, to obtain the second solution；5- is added in the second solution
20wt.% water, 0.01-1.0wt.% oxidizing alcohols SYNPERONIC PE/F68,0-60wt.% alcohol and 0.1-
0.5wt.% erosion resistant agent, polishing water to 100wt.%, with the liquid that is sterilized.
On the introduction of each composition of the thimerosal, " thimerosal " part of this specification is referred to.
Non-woven fabrics containing thimerosal
Some aspects of the disclosure provide a kind of non-woven fabrics containing thimerosal, including：Non-woven fabrics and it is dispersed in the nonwoven
The thimerosal according to the disclosure in cloth；Wherein, the gross weight by the non-woven fabrics is based on 100wt.%, the nonwoven cloth bag
Include：0-50wt.% viscose rayon and 50-100wt.% polyester fiber；The weight of the thimerosal and non-woven fabrics ratio
For 3:1-6:1.
On the introduction of each composition of the thimerosal, " thimerosal " part of this specification is referred to.
According to some embodiments, the viscose rayon can select known those applicable viscose rayons.According to
Some embodiments, the viscose rayon can be made by the following method：Native cellulose is alkalized to obtain alkali fiber
Element, sig water is dissolved in by alkali cellulose and carbon disulfide reaction generation cellulose xanthate ester, then by cellulose xanthate ester
In obtain viscous solution (viscose glue), viscose glue fibre is made in wet spinning and aftertreatment technology known to the viscous solution (viscose glue) warp
Dimension.
According to some embodiments, the polyester fiber can select known those applicable polyester fibers.According to
Some embodiments, the polyester fiber can be made by the following method：By p-phthalic acid (PTA) or to benzene two
Poly terephthalic acid second two is made through esterification or ester exchange, then by polycondensation reaction in formic acid dimethyl ester (DMT) and ethylene glycol (EG)
Alcohol ester (PET), then polyester fiber is made in spinning known to warp and aftertreatment technology.
The method for preparing the non-woven fabrics containing thimerosal
Some aspects of the disclosure provide a kind of method for preparing the non-woven fabrics containing thimerosal, including step, will be according to this
Disclosed thimerosal is distributed in non-woven fabrics, wherein, the gross weight by the non-woven fabrics is based on 100wt.%, the nonwoven cloth bag
Include：0-50wt.% viscose rayon and 50-100wt.% polyester fiber；The weight of the thimerosal and non-woven fabrics ratio
For 3:1-6:1.
On the introduction of the thimerosal, refer to this specification "Thimerosal" part.
On the introduction of the non-woven fabrics, refer to this specification "Non-woven fabrics containing thimerosal" part.
The application of non-woven fabrics containing thimerosal
Some aspects of the disclosure provide a kind of non-woven fabrics containing thimerosal according to the disclosure in medical cleaning-sterilizing
Application.
The body surface in the contact of the non-woven fabrics containing the thimerosal hospital according to the disclosure can be used, to realize cleaning-sterilizing
Purpose.
Following detailed description is intended to exemplarily and in non-limiting manner illustrate the disclosure.
Embodiment 1 is a kind of thimerosal, the gross weight by the thimerosal based on 100wt.%, including：0.1-
1wt.% quaternary ammonium salt；0.01-1wt.% caprylates；0.01-1wt.% oxidizing alcohol oxirane epoxy
Propane copolymer；37-99.88wt.% water；With 0-60wt.% alcohol.
Embodiment 2 is a kind of thimerosal according to embodiment 1, wherein, with the thimerosal
Based on 100wt.%, the quaternary ammonium salt includes gross weight：(i) 0.05-0.95wt.% single-stranded quaternary ammonium salt；(ii) 0.05-
0.95wt.% double-chain quaternary ammonium salt.
Embodiment 3 is a kind of thimerosal according to embodiment 2, wherein, the single-stranded quaternary ammonium salt
Including at least one of following group composition：C12-C18 zephirans, C12-C18 alkyldimethylbenzylammoniums
Ammonium bromide, C12-C18 alkyl trimethyls benzyl ammonium chloride and C12-C18 alkyl trimethyl Benzylphosphonium Bromide ammoniums.
Embodiment 4 is a kind of thimerosal according to embodiment 2 or 3, wherein, the double-strand quaternary ammonium
Salt includes at least one of following group composition：The double alkyl dimethyl brominations of C8-C18 Dialkyl dimethyl ammonium chlorides, C8-C18
Ammonium.
Embodiment 5 is a kind of thimerosal according to any one of embodiment 1 to 4, wherein, it is described
Caprylates include at least one of following group composition：The smooth caprylate of sorb, the smooth oleate of sorb, the smooth tristearin of sorb
Acid esters and sorbitan monopalmitate.
Embodiment 6 is a kind of thimerosal according to any one of embodiment 1 to 5, wherein, it is described
The carbon number of oxidizing alcohol SYNPERONIC PE/F68 is 12-15.
Embodiment 7 is a kind of thimerosal according to any one of embodiment 1 to 6, wherein, it is described
Alcohol includes at least one of following group composition：Ethanol and isopropanol.
Embodiment 8 is a kind of thimerosal according to any one of embodiment 1 to 7, wherein, with institute
The gross weight of thimerosal is stated based on 100wt.%, the thimerosal also includes 0.1-0.5wt.% erosion resistant agent.
Embodiment 9 is a kind of thimerosal according to embodiment 8, wherein, the erosion resistant agent includes
At least one of following group composition：Chromate, nitrite, silicate, molybdate, tungstates, Quadrafos and zinc salt.
Embodiment 10 is a kind of method for preparing thimerosal, including step：Will be any in embodiment 1-9
Each composition mixing of thimerosal described in.
Embodiment 11 is the method according to embodiment 10, wherein, with the gross weight of the thimerosal
Amount is based on 100wt.%, including step：0.1-1wt.% quaternary ammonium salt is added in 5-20wt.% water, it is molten to obtain first
Liquid；0.01-1.0wt.% caprylates are added in the first solution, to obtain the second solution；In the second solution
5-20wt.% water, 0.01-1.0wt.% oxidizing alcohols SYNPERONIC PE/F68 and 0-60wt.% alcohol are added,
Polishing water is to 100wt.%, with the liquid that is sterilized.
Embodiment 12 is the method according to embodiment 10, wherein, with the gross weight of the thimerosal
Amount is based on 100wt.%, including step：0.1-1wt.% quaternary ammonium salt is added in 5-20wt.% water, it is molten to obtain first
Liquid；0.01-1.0wt.% caprylates are added in the first solution, to obtain the second solution；In the second solution
Add 5-20wt.% water, 0.01-1.0wt.% oxidizing alcohols SYNPERONIC PE/F68,0-60wt.% alcohol and
0.1-0.5wt.% erosion resistant agent, polishing water to 100wt.%, with the liquid that is sterilized.
Embodiment 13 is a kind of non-woven fabrics containing thimerosal, including：Non-woven fabrics and it is dispersed in the non-woven fabrics
The thimerosal according to any one of embodiment 1-9；Wherein, 100wt.% is pressed with the gross weight of the non-woven fabrics
Meter, the non-woven fabrics include：0-50wt.% viscose rayon and 50-100wt.% polyester fiber；The thimerosal and described
The weight ratio of non-woven fabrics is 3:1-6:1.
Embodiment 14 is a kind of method for preparing the non-woven fabrics containing thimerosal, including step, by specific embodiment party
Thimerosal any one of formula 1-9 is distributed in non-woven fabrics, wherein, 100wt.% is pressed with the gross weight of the non-woven fabrics
Meter, the non-woven fabrics include：0-50wt.% viscose rayon and 50-100wt.% polyester fiber；The thimerosal and described
The weight ratio of non-woven fabrics is 3:1-6:1.
Embodiment 15 is a kind of non-woven fabrics containing thimerosal according to embodiment 13 medical clear
Application in clean sterilization.
Embodiment
Examples provided below and comparative example help to understand the present invention, and these embodiments and contrast are implemented
Example should not be construed as limiting the invention.Except as otherwise noted, all parts and percentages are by weight.
The raw material used in embodiments of the invention and comparative example is as shown in table 1 below.
The raw material used in the embodiment of table 1 and comparative example
The preparation of thimerosal
Under conditions of normal temperature (10-25 DEG C) and normal pressure (about 1 atmospheric pressure), pressed with the gross weight of the thimerosal
100wt.% is counted, and each composition of thimerosal is added in glass or rustless steel container according to following steps and mixed, to be disappeared
Venom：0.1-1wt.% quaternary ammonium salt is added in 5-20wt.% water, to obtain the first solution；Added in the first solution
0.01-1.0wt.% caprylates, to obtain the second solution；In the second solution add 5-20wt.% water,
The alcohol of 0.01-1.0wt.% oxidizing alcohols SYNPERONIC PE/F68 and 0-60wt.%, polishing water to 100wt.%,
With the liquid that is sterilized.
In addition, by the gross weight of the thimerosal based on 100wt.%, first solution, can also enter as needed
One step includes 0.1-0.5wt.% erosion resistant agent.
The preparation of non-woven fabrics containing thimerosal
According to the weight of thimerosal and non-woven fabrics ratio under conditions of normal temperature (10-25 DEG C) and normal pressure (about 1 atmospheric pressure)
For 3:1-6:1 ratio, thimerosal is distributed in non-woven fabrics, to obtain the non-woven fabrics containing thimerosal.
According to some embodiments, the thimerosal can be distributed to nothing by way of spraying, infiltrating etc. and be applicable
Spin in cloth, to obtain the non-woven fabrics containing thimerosal.
The disclosure is assessed containing thimerosal by " rate of drying is tested after the non-woven fabrics containing thimerosal wipes body surface "
Non-woven fabrics in thimerosal body surface drying capacity.
The disclosure assesses the corrosivity of thimerosal in the non-woven fabrics containing thimerosal by " erosion test ".
The disclosure assesses the bactericidal property of thimerosal in the non-woven fabrics containing thimerosal by " sterilizing ability test ".
The disclosure assesses non-woven fabrics in the non-woven fabrics containing thimerosal by " compatibility test of thimerosal and non-woven fabrics "
With the compatibility of thimerosal.
Rate of drying is tested after non-woven fabrics containing thimerosal wipes body surface
It is 3 by weight by thimerosal and non-woven fabrics:1-6:1 is mixed, and obtains the non-woven fabrics containing thimerosal；
Choose 30 × 30cm body surfaces (such as glass surface, lacquer painting, frosting etc.)；
By the non-woven fabrics containing thimerosal, with S type wiping methods, need to wipe in as above body surface wiping 1 time, wiping
To all areas of body surface, do not repeat to wipe.Visually observe, and record time when all areas wipings of body surface finish
t1Time t during with surface without visible liquid2；(note：Range estimation judges that wiping surface is completely dry when surface is without visible liquid
It is dry.)
Calculate drying time t, t=t2-t1；
If drying time t is less than 180 seconds, then it represents that surveys the non-woven fabrics containing thimerosal and wipes the drying energy after body surface
Power is qualified.
Erosion test
Write with reference to ministry of Health of China《Disinfection technology standard -2002》Requirement, carry out erosion test：
(1) sheet metal (stainless steel substrates, iron plate, copper sheet, aluminium flake, stainless steel substrates) of cleaning is subjected to surface polishing, be used in combination
Isopropyl alcohol wipe down.Claim 3 times after balance back to zero, using its average value as experiment after weight.
(2) coupon is numbered and dated, hang in thimerosal with plastics linear system with label.Disposable immersion
72h.Every kind of metal is tested every time places 3 prints.
(3) after being dipped into the stipulated time, sheet metal is taken out, is first rinsed with running water, then with hairbrush or other soft utensils
Remove corrosion product.As still there is the corrosion product for removing not fall, remove as follows:
Copper sheet:Being soaked in hydrochloric acid solution at room temperature, (hydrochloric acid of 500ml 36%~38% adds distilled water to 1000ml, hydrochloric acid
Proportion be 1.19) in 1min~3min.
Carbon steel coupon：In the sodium hydroxide solution for putting zincilate 200g/L, 5min~30min is boiled.
Aluminium flake：It is soaked in chromium trioxide phosphoric acid solution and (chromium trioxide 20g, phosphoric acid 500ml, adds distilled water to 1000ml.Phosphorus
Sour proportion continues 5min~10min in 1.69), to be warming up to 80 DEG C.It is as clean in do not removed also, nitric acid (ratio can be dipped in room temperature
Weigh 1min in 1.42) solution.
Stainless steel：It is soaked in 60 DEG C of salpeter solutions (66%~68% nitric acid 100ml adds distilled water to 1000ml) 20min.
Or it is dipped in 10min~60min in 70 DEG C of ammonium citrate solutions (ammonium citrate 150g adds distilled water to 1000ml).
(4) after coupon removes corrosion product and cleaned, with coarse filter paper suck dry moisture, it is placed in the plate for being lined with filter paper
In, 50 DEG C of incubators are put into, 1h is dried, is gripped with tweezers, weighed respectively on balance after its temperature is down to room temperature.Balance back to zero
Afterwards claim 3 times, using its average value as test after weight.It is identical with before experiment when weighing, cleaning gloves should be worn, it is not direct with hand
Contact print (similarly hereinafter).
(5) print need to set corresponding blank control with correction error when removing erosion with chemical method.Blank control print
It is same with test group print to be surface-treated, cleaned and weighed, but soaked without disinfectant.Used afterwards in company with test group print
Same procedure is chemically treated, water rinsing, drying, is weighed, and calculates its average weightless value.
(6) result of the test, observation and record sheet metal color change, and expressed with rate of metal corrosion (R) average value,
The weightless value of blank control group print should be subtracted during calculating.Calculation formula is as follows
[R is corrosion rate, mm/a (millimeter/year)；M for experiment before metal sheet weight, g；mtFor sheet metal weight after experiment
Amount, g；mkRemove corrosion product print weightless value for chemical treatment, g does not carry out chemical scavenging processor in experiment, during calculating
Leave out m in formulakValue；S be sheet metal surface area total value, cm2；T is test period, h；D is metal material density, kg/m3]。
Corrosivity grade scale：
| Corrosion rate R (mm/a) | Rank |
| <0.0100 | No corrosion |
| 0.0100~<0.100 | Mild corrosion |
| 0.100~<1.00 | Moderate corrosion |
| ≥1.00 | Severe is corroded |
Sterilizing ability is tested
Reference《Disposable Sanitary Accessory sanitary standard》, appendix C sterilizing ability method of testing：
(1) test organisms 24h slant cultures are washed down with PBS, be made bacteria suspension (it is required that concentration be：With 100 μ L drops in
Compare on print, bacterial count recovered is 1 × 104~9 × 104cfu/ pieces).Take by coupons (2.0cm × 3.0cm) and control print
(with sample homogeneous material, equal size, but being free of anti-biotic material, and sterilized processing) is each 4, is divided into 4 groups and is placed in 4 sterilizings
In plate.
(2) above-mentioned bacteria suspension is taken, 100 μ L is added dropwise in coupons and control print each respectively, even spread, started
Timing, effect 2,5,10,20min, print is put into the test tube of the corresponding nertralizer containing 5mL with sterile tweezer, fully mixed respectively,
Make appropriate dilution, then take wherein 2~3 dilution factors, draw 0.5mL respectively and be placed in two plates, with cool to 40~45 DEG C
Nutrient agar (bacterium) or sabouraud's agar (saccharomycete) 15mL are poured into, and are rotated plate, are made its full and uniform,
Flat board, 35 DEG C of ± 2 DEG C of culture 48h (bacterium) or 72h (saccharomycete) are overturn after agar solidification, makees the counting of viable bacteria bacterium colony.
Experiment is repeated 3 times, and sterilizing rate is calculated by formula (C1)：
X3=(A-B)/A × 100% --- (C1)
In formula：X3-- sterilizing rate, %；
A-- control sample average colony number；
B-- subject sample average clump count.
When sterilizing rate >=99.999%, killing bacteria effect is excellent；As 99.9%≤sterilizing rate ＜ 99.999%, carefully
Bacterium killing effect is good；As sterilizing rate ＜ 99.9%, killing bacteria effect is unqualified.
The compatibility test of thimerosal and non-woven fabrics
1. by disinfectant and non-woven fabrics according to 3:1-6:1 weight is mixed, and is placed 1 week after mixing.
Disinfectant is extruded from non-woven fabrics after 2.1 weeks, tests quaternary ammonium salt content in extrusion liquid.Quaternary ammonium salt content measuring side
Method is as follows：
1) precision weighs sample about 10g (record numerical value, keep after decimal point 4), as conical flask (250ml).
2) take 10ml distilled water to wash away wall of cup, add 40ml distilled water.
3) 1ml 1mol/l sodium hydroxides are added.
4) 0.4ml bromophenol blues are added with liquid-transfering gun.10ml chloroforms are measured, add rotor (large size), stirring.
5) tetraphenylboron sodium titer is transferred to 50ml burets, pays attention to carrying out rinse.
6) primary data is recorded, is shaken up in drop.Close to during terminal need strong oscillating shake.
7) treat that last time is changed into lavender, the blueness disappearance of lower floor's chloroform layer, record tetraphenylboron sodium titrating solution dosage V.Repeat
Survey 3 times, take the average value of 3 times to be calculated as follows:
W%=C × V × 0.342/M × 100%,
Wherein,
W is quaternary ammonium salt release rate from non-woven fabrics；
C is tetraphenylboron sodium concentration；
V is tetraphenylboron sodium dosage；
M is the weight of the quaternary ammonium salt weighed.
As W >=60%, the compatibility of thimerosal and non-woven fabrics is preferably；Work as W<When 60%, thimerosal and non-woven fabrics it is simultaneous
Capacitive is bad.
Embodiment 1-5 and comparative example 1-10
Composition and its dosage according to listed by table 2a, table 2b and table 2c respectively, method as described above prepare sterilization
Liquid and the non-woven fabrics containing thimerosal.
Method as described above carries out " rate of drying survey after the non-woven fabrics wiping body surface containing thimerosal respectively
Examination ", " erosion test " " sterilizing ability test " and " compatibility test of thimerosal and non-woven fabrics "." the nonwoven containing thimerosal
Rate of drying test after cloth wiping body surface " result is listed in table 3；" erosion test " result is listed in table 4a, 4b and 4c；" kill
Bacterium aptitude tests " result is listed in table 5；" compatibility test of thimerosal and non-woven fabrics " result is listed in table 6.
Table 2a
Table 2b
Table 2c
Non-woven fabrics of the table 3 containing thimerosal wipes drying time after body surface
According to table 2a, table 2b, table 2c and table 3：
In the non-woven fabrics containing thimerosal that embodiment 1-3 is provided, appropriate quaternary ammonium salt, sad esters are included in its thimerosal
Compound and oxidizing alcohol SYNPERONIC PE/F68, therefore drying time is short after non-woven fabrics wiping body surface, has
Good drying capacity.In the non-woven fabrics containing thimerosal that comparative example 1 provides, its thimerosal is not comprising appropriate sad esters
Compound, therefore, drying time is longer after non-woven fabrics wipes body surface, and drying capacity is unqualified.
In the non-woven fabrics containing thimerosal that comparative example 3 provides, its thimerosal does not include appropriate caprylates, because
This, drying time is longer after non-woven fabrics wipes body surface, and drying capacity is unqualified.
In the non-woven fabrics containing thimerosal that comparative example 4 provides, its thimerosal does not include appropriate caprylates, because
This, drying time is longer after non-woven fabrics wipes body surface, and drying capacity is unqualified.
In the non-woven fabrics containing thimerosal that comparative example 5 provides, its thimerosal does not include appropriate caprylates, because
This, drying time is longer after non-woven fabrics wipes body surface, and drying capacity is unqualified.
In the non-woven fabrics containing thimerosal that comparative example 6 provides, its thimerosal does not include appropriate caprylates, because
This, drying time is longer after non-woven fabrics wipes body surface, and drying capacity is unqualified.
Table 4a
Table 4b
Table 4c
According to table 2a, table 2b, table 2c, table 4a, table 4b and table 4c：
In the non-woven fabrics containing thimerosal that embodiment 1-3 is provided, appropriate quaternary ammonium salt, sad esters are included in its thimerosal
Compound and oxidizing alcohol SYNPERONIC PE/F68, therefore, its non-woven fabrics are not easy to body surface (particularly metal
Surface) cause to corrode.
In the non-woven fabrics containing thimerosal that comparative example 1 provides, its thimerosal does not include appropriate oxidizing alcohol oxirane
Epoxy propane copolymer, therefore, there is moderate corrosion to copper and iron.
In the non-woven fabrics containing thimerosal that comparative example 7 provides, its thimerosal does not include appropriate oxidizing alcohol oxirane
Epoxy propane copolymer, therefore, there is moderate corrosion to copper and iron.
In the non-woven fabrics containing thimerosal that comparative example 8 provides, its thimerosal does not include appropriate oxidizing alcohol oxirane
Epoxy propane copolymer, therefore, there is moderate corrosion to copper and iron.
Table 5
According to table 2a, table 2b, table 2c, table 5：
In the non-woven fabrics containing thimerosal that embodiment 1-3 is provided, appropriate quaternary ammonium salt, sad esters are included in its thimerosal
Compound and oxidizing alcohol SYNPERONIC PE/F68, therefore, be dispersed in thimerosal in non-woven fabrics to Escherichia coli,
Staphylococcus aureus, pseudomonas aeruginosa and Candida albicans all have good anti-microbial property.
In the non-woven fabrics containing thimerosal that comparative example 1 provides, its thimerosal comprising appropriate caprylates and
Oxidizing alcohol SYNPERONIC PE/F68, therefore, it is dispersed in antibacterial of the thimerosal in non-woven fabrics to Candida albicans
Performance deficiency.
In the non-woven fabrics containing thimerosal that comparative example 2, comparative example 7, and comparative example 8 provide, its thimerosal is not comprising appropriate
Oxidizing alcohol SYNPERONIC PE/F68, therefore, the thimerosal being dispersed in non-woven fabrics resists to Candida albicans
Bacterium performance deficiency.
Table 6
| Sample | Quaternary ammonium salt release rate W from non-woven fabrics |
| Embodiment 1 | 75% |
| Embodiment 4 | 90% |
| Embodiment 5 | 60% |
| Comparative example 9 | 47% |
| Comparative example 10 | 25% |
According to table 2a, table 2b, table 2c, table 6：
In the non-woven fabrics containing thimerosal that embodiment 1,4 and 5 provides, its non-woven fabrics includes appropriate viscose rayon and terylene
Fiber, its thimerosal include appropriate quaternary ammonium salt, caprylates and oxidizing alcohol SYNPERONIC PE/F68,
Quaternary ammonium salt is more than or equal to 60% from the release rate in non-woven fabrics, therefore, thimerosal and non-woven fabrics it is compatible good.
In the non-woven fabrics containing thimerosal that comparative example 9 provides, the content of polyester fiber is less than 50% in its non-woven fabrics, quaternary ammonium
Salt is less than 60% from the release rate in non-woven fabrics, therefore, thimerosal and non-woven fabrics it is compatible bad.
In the non-woven fabrics containing thimerosal that comparative example 10 provides, polyester fiber is free of in its non-woven fabrics, quaternary ammonium salt is from nonwoven
Release rate in cloth is less than 60%, therefore, thimerosal and non-woven fabrics it is compatible bad.
In summary, appropriate quaternary ammonium salt, caprylates and oxidizing alcohol are included according to the thimerosal of the disclosure
SYNPERONIC PE/F68, therefore the thimerosal has with the non-woven fabrics comprising appropriate viscose rayon and polyester fiber
Good compatibility, the thimerosal being dispersed in the non-woven fabrics not only have good bactericidal property, and in body surface
Drying time it is shorter, smaller to the corrosivity of metal surface.
Although for exemplary purposes, above-mentioned embodiment includes many details, this area is common
It should be understood to the one skilled in the art that many modifications of these details, change, replacement and change are in claimed model of the present invention
In enclosing.Therefore, the disclosure described in embodiment does not apply any restrictions to the claimed present invention.
The proper range of the present invention should be limited by claims and its appropriate legal equivalents.The bibliography of all references with
The mode of reference is incorporated by herein.
Claims (10)
1. a kind of thimerosal, the gross weight by the thimerosal based on 100wt.%, including：
0.1-1wt.% quaternary ammonium salt；
0.01-1wt.% caprylates；
0.01-1wt.% oxidizing alcohol SYNPERONIC PE/F68；
37-99.88wt.% water；With
0-60wt.% alcohol,
Wherein,
Based on 100wt.%, the quaternary ammonium salt includes gross weight by the thimerosal：
(i) 0.05-0.95wt.% single-stranded quaternary ammonium salt；With
(ii) 0.05-0.95wt.% double-chain quaternary ammonium salt；
The single-stranded quaternary ammonium salt includes at least one of following group composition：C12-C18 zephirans, C12-
C18 Alkyl dimethyl benzyl ammonium bromides, C12-C18 alkyl trimethyls benzyl ammonium chloride and C12-C18 alkyl trimethyl benzyl bromide a-bromotoluenes
Change ammonium；
The double-chain quaternary ammonium salt includes at least one of following group composition：C8-C18 Dialkyl dimethyl ammonium chlorides, C8-C18
Double alkyl dimethyl ammonium bromides；And
The caprylates include at least one of following group composition：The smooth caprylate of sorb, the smooth oleate of sorb, mountain
The smooth stearate of pears and sorbitan monopalmitate.
2. thimerosal according to claim 1, wherein, the carbon of the oxidizing alcohol SYNPERONIC PE/F68 is former
Subnumber is 12-15.
3. thimerosal according to claim 1, wherein, the alcohol includes at least one of following group composition：Ethanol and
Isopropanol.
4. thimerosal according to claim 1, wherein, the gross weight by the thimerosal is described to disappear based on 100wt.%
Venom also includes 0.1-0.5wt.% erosion resistant agent.
5. thimerosal according to claim 4, wherein, the erosion resistant agent includes at least one of following group composition：Chromium
Hydrochlorate, nitrite, silicate, molybdate, tungstates, Quadrafos and zinc salt.
6. a kind of method for preparing thimerosal, including step：By each of the thimerosal according to any one of claim 1-5
Composition mixes.
7. according to the method for claim 6, wherein, the gross weight by the thimerosal is based on 100wt.%, including step：
0.1-1wt.% quaternary ammonium salt is added in 5-20wt.% water, to obtain the first solution；
0.01-1.0wt.% caprylates are added in the first solution, to obtain the second solution；
5-20wt.% water, 0.01-1.0wt.% oxidizing alcohol SYNPERONIC PE/F68s is added in the second solution
With 0-60wt.% alcohol, polishing water to 100wt.%, with the liquid that is sterilized.
8. a kind of non-woven fabrics containing thimerosal, including：Non-woven fabrics and be dispersed in the non-woven fabrics according in claim 1-5
Thimerosal described in any one；
Wherein,
Based on 100wt.%, the non-woven fabrics includes gross weight by the non-woven fabrics：0-50wt.% viscose rayon and 50-
100wt.% polyester fiber；
The weight of the thimerosal and non-woven fabrics ratio is 3:1-6:1.
9. a kind of method for preparing the non-woven fabrics containing thimerosal, including step, by according to any one of claim 1-5
Thimerosal is distributed in non-woven fabrics, wherein, based on 100wt.%, the non-woven fabrics includes the gross weight by the non-woven fabrics：0-
50wt.% viscose rayon and 50-100wt.% polyester fiber；The weight of the thimerosal and non-woven fabrics ratio is 3:1-
6:1。
A kind of 10. application of non-woven fabrics according to claim 8 containing thimerosal in medical cleaning-sterilizing.
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