CN105188605A - Percutaneous transluminal angioplasty device with integral embolic filter - Google Patents

Abstract

A percutaneous transluminal angioplasty device includes an embolic filter mounted to the catheter shaft at a location distal to the angioplasty balloon. Thus the filter can be down-stream from the blockage and can be properly positioned to capture embolic particles that may be set loose into the blood stream as the angioplasty procedure can be performed. The embolic filter can be normally un-deployed against the catheter shaft to facilitate introduction and withdrawal of the device to and from the operative site. Once the angioplasty balloon can be properly positioned, however, means operatively associated with the embolic filter can be actuated to deploy the filter to position a filter mesh across the lumen of the vessel.

Description

There is the percutaneous transluminal angio plasty device of integrated thromboembolism filter

The cross reference of related application

This application claims the U.S. Provisional Application the 13/838th submitted on March 15th, 2013, the priority of No. 523, the full content of described U.S. Provisional Application is incorporated to way of reference at this.

Invention field

Implementation as herein described relates generally to surgery device, and relates more specifically to percutaneous transluminal angio plasty device.

Background technology

Vascular bed provides oxygen-rich blood steady flow to organ.In ill blood vessel, can form blocking, this can reduce the blood flowing to organ, and causes disadvantageous clinical symptoms, until and comprise death.Ill blood vessel can comprise a series of materials from early stage thrombosis to calcified plaque in late period.

Angioplasty can be described to performed to open blocked blood vessel by doctor and recover the operation based on conduit of blood flow.Such as can open entry site in the groin of patient, arm or hands, and seal wire and conduit can be advanced into the position of blocking under cryptoscope guiding.The conduit of the ballonet with its distal end contiguous can be advanced, until air bag is positioned at narrow zone under cryptoscope guiding.Air bag can then be inflated and bleed one or many, with the narrow zone of expansion artery.

Embolic particles can discharge from narrow location toward downstream by angioplasty.These embolic particles can cause disadvantageous clinical effectiveness.Shown to catch these embolic particles with prevent they follow blood flow to downstream proceed to capillary bed be favourable (such as, BaimDS, WahrD, GeorgeB etc., Randomizedtrialofadistalembolicprotectiondeviceduringper cutaneousinterventionofsaphenousveinaorto-coronarybypass grafts, Circulation2002; 105:1285-90).

Except balloon angioplasty, also can use support and use mechanical rotary-cut art (atherectomy) and thrombectomy (thrombectomy) device treatment stenosis.Embolic particles also can easily discharge from narrow location toward downstream by these devices.

For catch these embolic particles now can system primarily of filter system or occlusion balloons system composition, both are all based on seal wire.Usually, the filter mounting being configured to support filter membrane is arranged on the distal end place of filter seal wire.Filter mounting can move between advanced position and expanded position, and described in punctured position, support is near seal wire, and for the insertion of seal wire in patient body and retraction, and filter medium crosses over whole vasodilation substantially in expanded position.In use, the filter seal wire of prior art is inserted by the main tube cavity of angioplasty catheter, and is advanced in " touch-down zone " in narrow distally.Filter seal wire is then operated to the filter mounting launching to have filter medium, and described filter medium is attached and is configured to catch any thromboembolism discharged by angioplasty procedures.

These systems exist and use simplicity and use diameter can be greater than the filter of normally used seal wire or air bag guide wire passes the relevant shortcoming of fine and close pathological changes.Also there is pliability and stability problem in these thromboembolisms protection seal wire, makes protected angioplasty procedures relatively more difficult in many cases.When saphenous vein graft, problem is specifically related to aorta opening pathological changes, and wherein seal wire may fall short of to provide support; Or distal vein graft pathological changes and renal artery pathological changes, wherein may not there is enough filter touch-down zones.The latter may be a problem, because current available filtration system can have quite long distance between treatment air bag and distal end filter.This distance may be not only a problem in distal vein graft pathological changes, and is also a problem in stricture of artery, may there is side branch immediately, such as autologous coronary artery after narrow in stricture of artery.In this type of situation, filter may usually can only launch in the distally of side branch, and Shi Ce branch is not protected for embolic particles thus.

Therefore, there are the needs of the percutaneous transluminal angio plasty device to the improvement with integrated thromboembolism filter.

Summary of the invention

Should be appreciated that this general introduction is not to comprehensive review of the present disclosure.Originally be summarized as exemplary and nonrestrictive, and be both not intended to identify key of the present disclosure or important element, be also not intended to describe its scope.The sole purpose of this general introduction is to explain and illustration some concept of the present disclosure, as the preamble to following complete and comprehensive detailed description.

In general, the disclosure comprises a kind of percutaneous transluminal angio plasty device with integrated thromboembolism filter.Because filter can be integrated with the conduit of angioplasty equipment, so any needs to being inserted by self-contained unit in blood vessel can be eliminated.In addition, the appropriate placement of Angioplasty balloons can guarantee the appropriate placement of thromboembolism filter.

More particularly, the disclosure comprises a kind of conduit with elongated shaft, nearside and distal end, the longitudinal axis and filter.Filter comprises first ring on the extremity being fixedly mounted in conduit shaft coaxially, be slidably mounted in coaxially on the extremity of conduit shaft and be configured to towards first ring or away from the second ring of first ring movement and the support that extends between first ring and the second ring.Support also comprises multiple first longitudinal connecting component, and each first longitudinal connecting component has the first end being attached to first ring and the second end extended towards the second ring; Multiple second longitudinal connecting component, each second longitudinal connecting component has the first end being attached to the second ring and the second end extended towards first ring.Each in first longitudinal connecting component and the second longitudinal connecting component also comprises: be formed in the bifurcated on its second end, each bifurcated comprises the first branch and the second branch; With the device of the branch on relative for the branch on each in multiple first longitudinal connecting component being connected in multiple second longitudinal connecting component.Described filter also comprises the film being at least connected to support.

The further feature of example implementations of the present disclosure and advantage will be illustrated in the following description, and will be partly apparent from description, maybe can be understood by the practice of this kind of example implementations.Can realize by means of the instrument specifically noted in claims and combination and obtain the feature and advantage of this kind of implementation.These and further feature will become more complete clear from the following description and the appended claims, maybe can be understood by the practice of this kind of example implementations as illustrated hereinafter.

Accompanying drawing explanation

Be incorporated to this description and the accompanying drawing forming the part of this description illustrates various aspects, and together with describing the principle being used for explaining described method and system.

Fig. 1 illustrates the side view of an aspect of the angioplasty equipment with integrated thromboembolism filter.

Fig. 2 A illustrates the sectional view with the proximal end of the angioplasty equipment of integrated thromboembolism filter shown in Fig. 1; And Fig. 2 B illustrates the sectional view of the distal end of the device shown in Fig. 1.

Fig. 3 illustrates the schematic diagram of an aspect of the filter mounting of the angioplasty equipment shown in Fig. 1, and the filter mounting being in non-expanded position is shown.

Fig. 4 illustrates the schematic diagram of the filter mounting of Fig. 3, and the filter mounting being in expanded position is shown.

Fig. 5 illustrates the schematic diagram of another aspect of the filter mounting of the angioplasty equipment of Fig. 1, and the filter mounting being in non-expanded position is shown.

Fig. 6 illustrates the schematic diagram of the filter mounting of Fig. 5, and the filter mounting being in expanded position is shown.

Fig. 7 illustrates the schematic diagram of the 3rd aspect of the filter mounting of the angioplasty equipment of Fig. 1, and the filter mounting being in non-expanded position is shown.

Fig. 8 illustrates the schematic diagram of the filter mounting of Fig. 7, and the filter mounting being in expanded position is shown.

Fig. 9 illustrates to have narrow blood vessel.

Figure 10 illustrates that Fig. 9's has narrow blood vessel, is wherein positioned with the angioplasty equipment of Fig. 1.

Figure 11 illustrates blood vessel and the angioplasty equipment of Figure 10, and wherein integrated thromboembolism filter is expanded.

Figure 12 illustrates blood vessel and the angioplasty equipment of Figure 10, and wherein Angioplasty balloons and integrated thromboembolism filter launch.

Figure 13 illustrates blood vessel and the angioplasty equipment of Figure 10 after narrow treatment, and wherein Angioplasty balloons is in its non-expanded position and thromboembolism filter is still in its expanded position.

Figure 14 illustrates blood vessel and the angioplasty equipment of Figure 10 after narrow treatment, and wherein Angioplasty balloons and thromboembolism filter are all in non-expanded position, for from blood vessel, withdrawing device is prepared.

Figure 15 illustrates another aspect of the filter mounting comprising waveform framework.

Figure 16 illustrates an aspect of the attachment of waveform framework.

Figure 17 illustrates the side view of another aspect of the angioplasty equipment with integrated thromboembolism filter, and wherein therapy equipment is positioned at the distally of filter.

Detailed description of the invention

More easily the present invention can be understood by reference to following detailed description, embodiment, graphic and claim and the description before and after them.But, before this device of disclosure and description, system and/or method, should be understood that unless otherwise indicated, otherwise the invention is not restricted to disclosed concrete device, system and/or method, thus certainly can change.Should also be understood that term as used herein only for the object describing particular aspects, and be not intended to be limited.

There is provided following invention description as the instruction that can realize of current known best aspect of the present invention.For this reason, those skilled in the relevant art are by understanding and understand and can make many changes to various aspects of the present invention described herein, and still obtain beneficial outcomes described herein.Also it will be clear that, some in the beneficial effect of expectation as herein described by selecting some in feature as herein described, and can not use other features to obtain.Therefore, the practitioner of this area carries out many improvement by recognizing to the present invention and amendment is possible, and may be even wish and be a part of the present invention in some cases.Therefore, below describe be as illustrate principle as herein described and provide and not its restriction among.

The various aspects of one or more implementation of the present invention are described referring now to accompanying drawing.Should be understood that accompanying drawing is the diagram of one or more implementation and schematically shows, and do not limit the disclosure.In addition, although in being considered to provide each accompanying drawing to the effective ratio of one or more implementation, these accompanying drawings there is no need to draw all in proportion all implementations contained.Therefore, accompanying drawing represents exemplary ratios, but should not make the deduction about any required ratio from accompanying drawing.

In the following description, propose many details, well understand described herein to provide.But, to those skilled in the art, it will be clear that the disclosure can be implemented and without the need to these details.In other cases, in order to avoid the various aspects of unnecessarily fuzzy disclosed implementation, the well-known aspect of percutaneous transluminal angio plasty device and thromboembolism filter is not described in detail.

As description and as described in claim use, except the other clear stipulaties of context, otherwise singulative " ", " one " and " described " comprise plural referents.Scope can be expressed as in this article from " about " particular value and/or to " about " another particular value.When such a range is expressed, another aspect comprises from this particular value and/or to another particular value.Similarly, when by using antecedent " about " that value is expressed as approximation, will be appreciated that this particular value defines another aspect.Should be further understood that, the end points of each described scope is significant relative to another end points, and independent of another end points.

" optional " or " optionally " means the event that describes subsequently or situation can occur or can not occur, and describe and comprise situation that wherein said event or situation occur and wherein its nonevent situation.

Run through description and the claim of this description, word " comprises (comprise) " and the version of described word means " including but not limited to " as " comprising (comprising) " and " comprising (comprises) " and is not intended to get rid of such as other additive, component, integer or step." exemplary " means " ... example " and be not intended to the instruction of passing on preferred or desirable aspect." as " do not use with restrictive, sense, but for explanatory object.

Referring now to accompanying drawing, wherein run through each view same numeral instruction identity element, Fig. 1 illustrates according to first aspect with the angioplasty catheter 10 of integrated thromboembolism filter of the present invention.The angioplasty catheter 10 with integrated thromboembolism filter comprises slender conduit 12, and described slender conduit 12 has shaft 14, and described shaft 14 has proximal end 16 and distal end 18.As used herein, " nearside " refers to the part of the doctor near execution operation of described device, and " distally " refers to the doctor's part farthest from execution operation of described device.Angioplasty therapy device 20 can be mounted to conduit 12 in the position of the distal end 18 near conduit shaft 14.Angioplasty therapy device comprises, such as and be not limited to, inflatable air bag, expandable stent, rotary-cut art and thrombectomy device etc.Thromboembolism filter 30 can be mounted to conduit shaft 14 in the distally of angioplasty therapy device 20 at distal end 18 place of conduit 12 or the position of nearside.As shown in figure 17, also consider, thromboembolism filter 30 can be mounted to conduit shaft 14 in the position of the nearside of therapy equipment 20.In embodiment that is other or that substitute, filter 30 can be oriented to towards or away from therapy equipment.Those skilled in the art also will recognize according to the disclosure, and angioplasty catheter can be configured to, and such as and be not limited to, overallly exchange (over-the-wire) conduit, rapid-exchange catheter etc.Only for disclosed clear for the purpose of, this description describes overall exchanging pipe form.

Referring now to Fig. 2, conduit shaft 14 can limit three tube chambers: main tube cavity 32, Angioplasty balloons expansion tube cavity 34 and thromboembolism filter actuator wire tube chamber 36.Main tube cavity 32 can extend to distal end 18 from the proximal end 16 of conduit shaft 14.Main tube cavity 32 optionally provides service aisle and is configured to the seal wire that is received through wherein, is used for the distal end 18 of propulsion bulb 12 through the vascular system of patient to therapentic part.As used herein, term " therapentic part " refers to the position of patient vessel's system internal congestion, and when conduit 12 be regarded as be positioned at or be positioned described therapentic part time, understanding meant, described conduit is positioned such that angioplasty therapy device 20 is positioned at obstruction.

Balloon expansion lumen 34 can extend from the proximal hole 38 of the proximal end 16 at conduit 12 and pass conduit shaft 14 to the distal hole 40 being positioned at angioplasty therapy device 20.Similarly, actuator wire tube chamber 36 can extend from the proximal hole 44 of the proximal end 16 at conduit 12 and pass conduit shaft 14 to the distal hole 46 in angioplasty therapy device 20 distally.

Unless otherwise indicated, otherwise preceding feature is shared in following public all aspects, and the difference of various aspects is mainly the design of thromboembolism filter.Therefore, when open various aspects, will understand, unless otherwise indicated, otherwise each aspect comprises preceding feature, and described description by then concentrate on design and the operation of thromboembolism filter.

With reference to the aspect of the present disclosure shown in Fig. 3 and Fig. 4, thromboembolism filter 30 comprises filter membrane 50 (Figure 12) and the Collapsible rack 52 for supporting described filter membrane, described filter membrane 50 have optionally size is set as allowing blood by but catch the hole of the granule being greater than normal blood granule.For clarity, when illustrating support 52, accompanying drawing omits filter membrane 50, but should be understood that all thromboembolism filters disclosed in the application all comprise the filter membrane supported by described support.Be susceptible to, support 52 can comprise proximal ring 56 and distally ring 54.In one aspect, two rings all can be positioned between the distal end of angioplasty therapy device 20 and the distal end 18 of conduit shaft.In yet another aspect, distally ring 54 can be fixed on the appropriate location on conduit shaft 14, and proximal ring 56 can be slidably mounted to conduit shaft, for moving axially on nearside and distal direction.

Each in multiple first column sections 60 has first end 62 and the second end 64.The first end 62 of each first column sections 60 can be attached to distally ring 54, and each first column sections can extend in a proximal direction.

In other respects, each in corresponding multiple second column sections 70 has first end 72 and the second end 74.At this, the first end 72 of each second column sections 70 can be attached to proximal ring 56, and each second column sections also can extend in a proximal direction.

In other, multiple second column sections 70 can substitute with the waveform ring structure 55 as shown in Figure 15-16.In this, waveform ring 55 increases along with the relative distance between distally ring and proximal ring and radially inwardly shrinks, and reduces along with the relative distance between distally ring and proximal ring and expand.

In other, the second end 64 of each first column sections 60 can be attached to the second end 74 of the second corresponding column sections 70.At this, each the first connected column sections 60 and the second column sections 70 jointly form pillar 80.As those skilled in the art will understand from discussion above, multiple pillar 80 can be circumferentially spaced apart with distally ring and be connected proximal ring and distally ring, to form support 52 around proximal ring.In operation and as shown in Figure 3, when proximal ring 56 and distally ring 54 located adjacent one another time, each pillar 80 can be configured to go back on himself.In addition, when distally ring 54 proximad is shifted proximal ring 56, pillar 80 can be configured to open in the mode of similar umbrella.Filter membrane 50 can be supported in the first column sections 60, makes when support 52 is opened, and as shown in Figure 4, described filter membrane can the mode of similar umbrella cover launch.

Be susceptible to, each pillar also can comprise at least one " weakness district ", and namely the most of position being configured to physically be weaker than pillar of pillar to bend the region of position at place to control pillar.It will be appreciated by those skilled in the art that can in many ways in any one form at least one weakness district described.In one aspect, groove can be formed in the one or both sides of pillar.In yet another aspect, at least one the be formed indentation in the upper surface of pillar and lower surface.In yet another aspect, at least one weakness district can be formed by material that can be structurally weak than the material forming pillar remainder.In other, at least one weakness district can comprise mechanical hinge.In other and as shown in Figure 15, the top of waveform ring 55 comprises weakness district.In other, at least two in these methods can combine to form at least one weakness district, and such as, both recessing on the width of pillar, formed indentation again in depth.In addition, at least one weakness district can comprise the physical layout of a multiple type, and such as single weakness district can comprise multiple groove or multiple indentation.In operation, at least one weakness district can be configured to become the power of predetermined angular to make post bends in response to the longitudinal axis of that part relative to pillar.

In operation, proximal ring 56 has been come towards with away from distally ring 54 with the operation of the movement opening and closing thromboembolism filter 30 by actuator wire 84.In one aspect, the proximal end 86 of actuator wire 84 can be extended out the proximal hole 44 of actuator wire tube chamber 36, can be controlled by the doctor performing operation.At this, actuator wire 84 can extend across actuator wire tube chamber 36 and distal hole 46 by actuator wire tube chamber is gone out.In yet another aspect, the distal end 88 of actuator wire 84 can be attached to proximal ring 56.

It will be understood by those skilled in the art that has various ways to can be used for arranging filter mounting 52 and actuator wire 84, to allow to carry out open and close thromboembolism filter 30 by the proximal end 86 of mobile actuator wire at this.In first aspect, filter mounting 52 can be formed at normally closed or non-expanded position.In operation, pull the proximal end 86 of actuator wire 84 that proximal ring 56 can be made proximally to slide with opened filter holder 52 in direction.Filter mounting can be constructed such that to be released in the tension force on actuator wire 84 and/or distad promote actuator wire 84 and filter mounting 52 can be allowed to be folded into non-expanded position.

Of the present disclosure in another shown in Fig. 5 and Fig. 6, filter mounting 152 can comprise proximal ring 156 and the distally ring 154 that can locate slidably on nearside and distal direction along conductor string that can be fixing relative to conduit shaft 114.In yet another aspect, the distal hole 146 of actuator wire tube chamber 136 can be positioned at the distally of proximal ring 156.At this, actuator wire (not shown) can extend across actuator wire tube chamber, goes out by distal hole 146, and can be attached to distally ring 154.Filter mounting 152 can be formed in normally closed position.In operation, promoting actuator wire 184 can make distally ring 154 at the distal direction superior displacement away from proximal ring 156, to launch filter mounting 152.Filter mounting can be constructed such that to be released in the power on actuator wire 184 and/or distad promote actuator wire 184 and filter mounting 152 can be made to recover its non-expanded position.

Of the present disclosure in another shown in Fig. 7 and Fig. 8, proximal ring 254 can be fixed relative to conduit shaft 214, and distally ring 256 can be located on nearside and distal direction slidably along conductor string.In yet another aspect, the distal hole 246 of actuator wire tube chamber 236 can be positioned at the distally of distally ring 256.At this, actuator wire 284 can extend across actuator wire tube chamber 236, goes out by distal hole 246, and can be attached to distally ring 256.Filter mounting 252 can be formed in normally closed position.In operation, actuator wire 284 is pulled can to make distally ring 256 in a distal direction and be shifted away from proximal ring 156, to launch filter mounting 252.Filter mounting can be constructed such that the power be released on actuator wire 284 can allow filter mounting 252 to recover its non-expanded position.

Refer again to Fig. 3 and Fig. 4, another aspect of filter mounting can be structurally identical with the first embodiment 52, except can normally open or expanded position formation filter mounting.At this, be susceptible to, proximal ring 56 can be remained in its distal position and therefore filter mounting 52 can be remained in its non-expanded position by the power (that is, the promoting actuator wire) proximal end 86 of actuator wire 84 being applied to point to distally.When release is applied to the power of actuator wire 84, filter mounting 52 can be allowed to be expanded to its normal expanded position, thus expansion filter membrane 50.After completing immediately preceding intervention procedures, again can apply to the proximal end 86 of actuator wire 84 power pointing to distally, thus make proximal ring 56 distally ring 54 move and pleated filter support 52.

Refer again to Fig. 5 and Fig. 6, the 5th aspect can be structurally identical with the 3rd aspect, except forming filter mounting 152 in the position of normally opening.At this, be susceptible to, distally ring 154 normally can be shifted towards the distal end 18 of conduit shaft 114.In operation, pull the distal end 188 of actuator wire 184 that distally ring 154 proximad can be made to move towards fixing proximal ring 156, thus pleated filter support 152 simultaneously the tension force discharged on actuator wire 184 filter mounting 152 can be allowed to be expanded to its expanded position.

Those power being applied to actuator wire is configured to axial compressive force in, those skilled in the art will be understood that, can use, than at those, power being applied to actuator wire is configured to line harder in the embodiment of axial tensile force, to prevent the rugosity of actuator wire.

In the disclosure, and especially with regard to actuator wire, term " silk " is intended to comprise, such as and be not limited to, tinsel, polymer filament etc.With regard to polymer filament, polymer used can comprise, such as and be not limited to, nylon, polypropylene etc.

In above-mentioned, filter membrane 50 can be formed by least one in fabric, polymer and silk screen.In yet another aspect, filter membrane 50 comprises hole, and in yet another aspect, hole can be dimensioned to allow blood to pass through, but does not allow embolic particles to pass through.Also be susceptible to, filter membrane 50 can be installed in top or the inside of framework.

In aforementioned, filter membrane 50 can be configured to the outer surface covering outermost column sections, that is, the first column sections 60,160 and 260.Optionally, filter membrane 50 can be configured to extend beyond distal end or the second end 64,164 and 264 of the first column sections 60,160 and 260 further, and wherein it can be attached to the circumference of distally ring 54,156,256.Those distally rings 54 can be fixed in, filter membrane 50 is optionally configured to the distal end extending beyond distally ring, and can be attached to the circumference of conduit shaft 14 in the position between the distally ring 54 of conduit shaft and distal end 18.

Also be susceptible to, the filter membrane 50 in each disclosed embodiment can be attached to the inner surface of the first column sections 60,160 and 260, instead of outer surface.

Also being susceptible to, when inner or the second column sections 70,170,270 also can be formed at and launch filter mounting, is spill relative to blood flow.In other or extra, filter membrane 50 can be attached to inner surface or the outer surface of the second column sections 70,170,270.When filter membrane 50 is attached to the second column sections 70,170,270 surperficial, filter membrane 50 optionally extends beyond distally or the second end 74,174,274 of these the second column sections, and is attached to the circumference of proximal ring 56,154,254.Also be susceptible to, if filter membrane 50 can be attached to the outer surface of the second column sections 70, and proximal ring 56 can be fixed, so described filter membrane can be configured to extend beyond the distal end of proximal ring and can be attached to conduit shaft 14 in the position between proximal ring 56 and distally ring 54.

In all aforementioned circumstances, filter mounting all comprises retainer ring and removable ring, by ring having been moved away from the rise of filter, and by ring having been moved together the folding of filter." move away from " and " moving together " is used as relative terms, making, in order to allow ring " move away from " or " moving together ", only needs one in two rings to move relative to another.

Similarly, the process of rise and pleated filter can be considered to viewed as the visual angle from conduit, makes it possible to removable ring and moves towards or away from retainer ring.

In all aforementioned circumstances, be understandable that, initiatively applying power moves to allow ring the step both comprising and carried out " causing " removable ring movement by " control " actuator wire with shift(ing) ring and release force automatically.Therefore, in normal expansion as herein described and the normal filter mounting embodiment do not launched, actuator wire can be moved with " causing " removable ring by " control ", and no matter this control is taked to apply the form of power to actuator wire or discharge the form of the power on actuator wire.

Also be susceptible to, allow with it doctor directly grasp the proximal end of actuator wire, not as the proximal end place of control device at conduit shaft being associated with the proximal end of actuator wire.Control device can comprise, and such as and be not limited to, control stick, slider, rotating shaft etc., to promote the movement of silk.Described by an example of this type of mechanical arrangement has in [0079] of U.S. Patent Publication No.US2010/0106182-[0090] section and Figure 29-33, described in be disclosed in this and be incorporated to way of reference.

Can purposes in narrow in treatment blood vessel of the angioplasty equipment with integrated thromboembolism filter above-mentioned shown in Fig. 9-13.In fig .9, blood vessel 500 can have the branch vessel 502 from its bifurcated.Blood vessel 500 can have narrow 504.Blood flow is indicated to pass through the direction of blood vessel 500 by arrow 506.As the preparation process in intervention procedures, seal wire 508 is inserted by doctor.

Figure 10 illustrates to have and is in its non-expanded position and the conduit 12 of the Angioplasty balloons 20 of adjacent pipes shaft 14 and thromboembolism filter 30.The distal end 18 of conduit shaft 14 is pushed into along seal wire 506, until by the Angioplasty balloons 20 of bleeding be present in narrow in.When conduit 12 is positioned such that Angioplasty balloons 20 can be positioned at narrow, conduit can be called as and is in its " target site " place.When conduit is in target site, the part occupied by thromboembolism filter 30 of blood vessel 500 can be called as " touch-down zone " 510.

In fig. 11, thromboembolism filter 30 is expanded by pulling actuator wire 84.In fig. 12, Angioplasty balloons 20 can be inflated and bled if necessary and again inflate, optionally repeatedly, to force narrow opening.Crushing in the process forming narrow speckle, embolic particles 510 is released and is brought into the proximal end of the opening of thromboembolism filter 30 by blood flow, and at this, they are filtered film 50 and catch.

In fig. 13, originally narrow region can be opens, and Angioplasty balloons 20 can be bled.Thromboembolism filter 30 stays open, to be captured in any thromboembolism of release when Angioplasty balloons 20 is bled and pulls away from the wall of blood vessel 500.

In fig. 14, thromboembolism filter 30 can be closed, thus is enclosed in filter by the thromboembolism of catching.Can extract conduit 12 out from blood vessel 500 now.

An aspect of each disclosed thromboembolism filter can be done like this: because pillar be folded back to they from it, the filter mounting being in non-expanded position can be shorter than the filter mounting of the thromboembolism filter of other known and/or commercially available acquisitions.Shorter length can allow shorter touch-down zone, then can allow filter be placed from angioplasty therapy device more close to.The probability that narrow blood vessel between angioplasty therapy device and thromboembolism filter intersects by the branch vessel providing a result in shorter touch-down zone to can be minimizing, thus minimizing thromboembolism walks around filter and chance captured in blood flow.

Therefore, aforesaid implementation provides different required features.Such as, disclosure permission thromboembolism filter is placed very near being used for the treatment of narrow device.This has the effect in " touch-down zone " minimizing filter, and allows protection side branch, as shown in Figure 22-25.

Therefore the present invention can embody when not departing from its spirit or substitutive characteristics in other specific forms.Described each side is all regarded as being only illustrative and nonrestrictive in every respect.Therefore scope of the present invention is indicate by claims instead of by aforementioned description.All changes in the implication and scope of the equivalent of described claim all will comprise within the scope of the claims.

Claims (16)

1. a device, it comprises:

Conduit, described conduit has elongated shaft, nearside and distal end and the longitudinal axis; And

Filter membrane supporting construction, it comprises:

First ring, described first ring is fixedly mounted on the extremity of described conduit shaft coaxially;

Second ring, described second ring is slidably mounted on the extremity of described conduit shaft coaxially, for moving towards with away from described first ring; And

Support, described support extends between described first ring and the second ring, described support be folding with expanded configuration between moveable, described support comprises:

First longitudinal connecting component, described first longitudinal connecting component has the first end being attached to described first ring and the second end extended towards described second ring;

Waveform ring structure, described waveform ring structure has radius, first group of top and second group of top, and wherein said first group of top is attached to described second ring, and described second group of top is attached to the second end of described first longitudinal connecting component.

2. device as claimed in claim 1, wherein said conduit also comprises the tube chamber be formed at wherein, and described tube chamber is from being formed in described conduit at the proximal end of described conduit or the second opening extending to the distal end being formed in close described conduit in described conduit near first opening at the proximal end place of described conduit.

3. device as claimed in claim 2, it also comprises the actuator wire of the tube chamber extending through described conduit, and described actuator wire has the proximal end of the first opening extending through described tube chamber and extends through the second opening in described tube chamber and the distal end be operationally associated with described second ring.

4. device as claimed in claim 3, wherein said support is folded by the shaft near described conduit under normal circumstances.

5. device as claimed in claim 4, described in wherein making described actuator wire applying tension force, slidably the second ring pulls to expand described support towards described first ring.

6. device as claimed in claim 5, wherein removes described tension force from described actuator wire and allows described support-folding to return shaft near described conduit.

7. device as claimed in claim 1, it also comprises the therapy equipment of the shaft being mounted to described conduit.

8. device as claimed in claim 7, wherein said therapy equipment can be positioned the nearside of described filter membrane supporting construction.

9. device as claimed in claim 7, wherein said therapy equipment can be positioned the distally of described filter membrane supporting construction.

10. device as claimed in claim 7, wherein said therapy equipment can comprise at least one in inflatable air bag, expandable stent, Atherectomy devices and thrombectomy device.

11. devices as claimed in claim 1, it also comprises the weakness be formed on described supporting frame, controlled bending to promote.

12. devices as claimed in claim 11, wherein said weakness comprises second group of top of described waveform ring structure.

13. devices as claimed in claim 1, it also comprises filter membrane.

14. devices as claimed in claim 13, wherein said filter membrane covers going up at least partially of described filter membrane supporting construction.

15. devices as claimed in claim 1, the radius of wherein said waveform ring structure is adapted to the increase of the relative distance between described first ring and described second ring and reduces.

16. devices as claimed in claim 1, the radius of wherein said waveform ring structure is adapted to the minimizing of the relative distance between described first ring and described second ring and increases.