CN105181781B - 具有微分离子迁移率谱仪和质谱仪的离子分析装置及使用方法 - Google Patents

具有微分离子迁移率谱仪和质谱仪的离子分析装置及使用方法 Download PDF

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CN105181781B
CN105181781B CN201510495958.7A CN201510495958A CN105181781B CN 105181781 B CN105181781 B CN 105181781B CN 201510495958 A CN201510495958 A CN 201510495958A CN 105181781 B CN105181781 B CN 105181781B
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vacuum
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CN105181781A (zh
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R·贾尔斯
D·帕帕纳斯塔休
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Shimadzu Corp
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G01N27/624—Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]

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  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
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CN201510495958.7A 2009-05-01 2010-04-30 具有微分离子迁移率谱仪和质谱仪的离子分析装置及使用方法 Active CN105181781B (zh)

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GB0907619.1 2009-05-01
GBGB0907619.1A GB0907619D0 (en) 2009-05-01 2009-05-01 Ion analysis apparatus and method of use
CN201080019355.5A CN102449727B (zh) 2009-05-01 2010-04-30 具有微分离子迁移率谱仪和质谱仪的离子分析装置及使用方法

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CN201080019355.5A Active CN102449727B (zh) 2009-05-01 2010-04-30 具有微分离子迁移率谱仪和质谱仪的离子分析装置及使用方法

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Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5237734B2 (ja) * 2008-09-24 2013-07-17 日本電子株式会社 収差補正装置および該収差補正装置を備える荷電粒子線装置
GB201205009D0 (en) * 2012-03-22 2012-05-09 Micromass Ltd Multi-dimensional survey scans for improved data dependent acquisitions (DDA)
GB2502155B (en) * 2012-05-18 2020-05-27 Fasmatech Science And Tech Sa Apparatus and method for controlling ions
WO2013171569A1 (en) * 2012-05-18 2013-11-21 Dh Technologies Development Pte. Ltd. Reducing interferences in isobaric tag-based quantification
GB2508574B (en) * 2012-06-24 2014-12-17 Fasmatech Science And Technology Sa Improvements in and relating to the control of ions
EP3892990A1 (en) 2013-03-06 2021-10-13 Micromass UK Limited Optimised ion mobility separation timescales for targeted ions
GB2512640A (en) * 2013-04-04 2014-10-08 Fasmatech Science And Technology Sa Improvements in and relating to the production and control of ions
GB201309282D0 (en) * 2013-05-23 2013-07-10 Shimadzu Corp Circuit for generating a voltage waveform
CN105308713B (zh) * 2013-06-21 2017-09-08 Dh科技发展私人贸易有限公司 用于质谱仪的污染物过滤器
EP3014648B1 (en) 2013-06-27 2018-10-24 Implant Sciences Corporation Dual polarity spark ion source
CN104282525A (zh) * 2013-07-01 2015-01-14 中国科学院大连化学物理研究所 一种大气压下的离子聚焦传输透镜
EP3033615A4 (en) * 2013-08-14 2017-03-22 DH Technologies Development PTE. Ltd. Ion mobility method and apparatus
EP3086114A4 (en) * 2013-12-17 2016-11-30 Shimadzu Corp MASS SPECTROMETERS AND MASS SPECTROMETRY PROCEDURES
CN103745906B (zh) * 2013-12-23 2016-04-27 聚光科技(杭州)股份有限公司 一种离子测量装置
CA2932671A1 (en) * 2013-12-31 2015-07-09 Dh Technologies Development Pte. Ltd. Vacuum dms with high efficiency ion guides
CA2932661A1 (en) * 2013-12-31 2015-07-09 Dh Technologies Development Pte. Ltd. Jet injector inlet for a differential mobility spectrometer
JP6090201B2 (ja) * 2014-02-19 2017-03-08 株式会社島津製作所 マススペクトルデータ処理装置及びマススペクトルデータ処理方法
GB2525194B (en) * 2014-04-14 2017-03-29 Thermo Fisher Scient (Bremen) Gmbh Method of assessing vacuum conditions in a mass spectrometer
CN104051220B (zh) * 2014-06-03 2017-01-18 清华大学深圳研究生院 一种离子分离装置
DE112015002725B4 (de) * 2014-06-11 2025-03-20 Micromass Uk Limited Verbesserte Quadrupolwiderstandsfähigkeit
GB201410369D0 (en) * 2014-06-11 2014-07-23 Micromass Ltd Monitoring IMS environment for improved CCS accuracy and precision
US10388505B2 (en) 2014-06-11 2019-08-20 Micromass Uk Limited Monitoring ion mobility spectrometry environment for improved collision cross section accuracy and precision
CN104237058A (zh) * 2014-09-23 2014-12-24 中国科学技术大学 一种热重分子束质谱联用装置
GB2531292B (en) * 2014-10-14 2019-06-12 Smiths Detection Watford Ltd Method and apparatus
CN107407658B (zh) * 2015-03-09 2020-08-07 株式会社岛津制作所 平行平板型不均匀电场离子迁移率分光装置
CN106340437B (zh) 2015-07-09 2019-03-22 株式会社岛津制作所 质谱仪及其应用的减少离子损失和后级真空负载的方法
AU2016310491B2 (en) 2015-08-21 2021-11-04 PharmaCadence Analytical Services, LLC Novel methods of evaluating performance of an atmospheric pressure ionization system
JP2017090393A (ja) * 2015-11-17 2017-05-25 株式会社島津製作所 イオン移動度分離装置
US10770279B2 (en) * 2015-11-27 2020-09-08 Shimadzu Corporation Ion transfer apparatus
US11067538B2 (en) * 2016-04-02 2021-07-20 Dh Technologies Development Pte. Ltd. Systems and methods for effective gap filtering and atmospheric pressure RF heating of ions
CN107271575B (zh) * 2016-04-08 2020-01-14 株式会社岛津制作所 离子迁移谱和质谱并行分析的方法及装置
US20190157059A1 (en) * 2016-04-19 2019-05-23 Micromass Uk Limited Transfer tube calibration
US10458944B2 (en) * 2016-06-03 2019-10-29 Bruker Daltonik Gmbh Trapped ion mobility spectrometer with high ion storage capacity
WO2018069982A1 (ja) * 2016-10-11 2018-04-19 株式会社島津製作所 イオンガイド及び質量分析装置
CN108091544B (zh) * 2016-11-21 2019-09-06 中国科学院大连化学物理研究所 一种基于微分迁移谱离子筛选的质谱化学电离源
CN109390206A (zh) * 2017-08-04 2019-02-26 中国科学技术大学 小型化便携式质谱仪及用于产生水团簇离子的离子源装置
WO2019142068A1 (en) * 2018-01-17 2019-07-25 Dh Technologies Development Pte. Ltd. Dm-swath acquisition to improve msms confidence
CN108404592B (zh) * 2018-05-10 2021-03-19 苏州大学附属第二医院 一种可有效提高集气效果的手术室用麻醉废气净化装置
JP2020020746A (ja) * 2018-08-03 2020-02-06 株式会社リコー 検出装置
CN112912991B (zh) * 2018-11-29 2025-01-24 株式会社岛津制作所 质量分析装置
GB2591069A (en) 2019-08-30 2021-07-21 Shimadzu Corp Device for performing field asymmetric waveform ion mobility spectrometry
GB2586787A (en) * 2019-08-30 2021-03-10 Shimadzu Corp Device for performing field asymmetric waveform ion mobility spectrometry
GB2586786A (en) * 2019-08-30 2021-03-10 Shimadzu Corp Device for performing field asymmetric waveform ion mobility spectrometry
US11293898B2 (en) 2020-02-06 2022-04-05 Thermo Finnigan Llc Duty cycle improvement for a mass spectrometer using ion mobility separation
CN113871284B (zh) * 2020-06-30 2025-04-25 株式会社岛津制作所 质谱仪
US11092569B1 (en) * 2020-07-05 2021-08-17 Cannabix Technologies Inc. Apparatus and methods for detection of molecules
US11273465B1 (en) * 2020-09-17 2022-03-15 Desaraju Subrahmanyam Tunable electrostatic ion and fluid flow generator and electroacoustic transducer
CN112595562B (zh) * 2020-12-11 2022-12-06 中国科学院工程热物理研究所 可灵活布置的质谱同温原位采样接口和质谱同温原位采样方法
CN115705992A (zh) * 2021-08-11 2023-02-17 株式会社岛津制作所 离子迁移谱-质谱联用分析装置
CN117012610A (zh) * 2022-04-28 2023-11-07 株式会社岛津制作所 质谱仪及其真空系统的形成方法
WO2024061469A1 (en) * 2022-09-23 2024-03-28 Shimadzu Corporation Differential ion mobility spectrometry
WO2024061468A1 (en) * 2022-09-23 2024-03-28 Shimadzu Corporation Differential ion mobility analysis
CN116110772B (zh) * 2023-01-29 2024-11-15 山东省分析测试中心 一种差分离子迁移谱-质谱联用离子传输系统及设备
EP4621402A1 (en) * 2024-03-19 2025-09-24 Bruker Switzerland AG Differential mobility spectrometer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2432255A (en) * 2005-11-10 2007-05-16 Micromass Ltd A mass spectrometer comprising an ion mobility separator
GB2443952A (en) * 2006-11-15 2008-05-21 Micromass Ltd Combined mass-to-charge ratio and charge state selection in tandem mass spectrometry
CN101416271A (zh) * 2006-05-22 2009-04-22 株式会社岛津制作所 平行板电极布置设备和方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000063949A1 (en) 1999-04-16 2000-10-26 Mds Inc. Mass spectrometer, including coupling of an atmospheric pressure ion source to a low pressure mass analyzer
WO2001069219A2 (en) * 2000-03-14 2001-09-20 National Research Council Canada Faims apparatus and method with laser-based ionization source
GB0031342D0 (en) 2000-12-21 2001-02-07 Shimadzu Res Lab Europe Ltd Method and apparatus for ejecting ions from a quadrupole ion trap
CA2391060C (en) 2001-06-21 2011-08-09 Micromass Limited Mass spectrometer
US7091481B2 (en) * 2001-08-08 2006-08-15 Sionex Corporation Method and apparatus for plasma generation
US7060987B2 (en) * 2003-03-03 2006-06-13 Brigham Young University Electron ionization source for othogonal acceleration time-of-flight mass spectrometry
ATE512458T1 (de) * 2004-12-07 2011-06-15 Micromass Ltd Massenspektrometer
US7351960B2 (en) 2005-05-16 2008-04-01 Thermo Finnigan Llc Enhanced ion desolvation for an ion mobility spectrometry device
WO2007056488A1 (en) 2005-11-07 2007-05-18 Sionex Corporation Method and apparatus for ion mobility based sample analysis
EP1982349B1 (en) * 2006-02-07 2018-07-25 DH Technologies Development Pte. Ltd. Chemical noise reduction for mass spectrometry
US20090283674A1 (en) 2006-11-07 2009-11-19 Reinhold Pesch Efficient Atmospheric Pressure Interface for Mass Spectrometers and Method
US7550717B1 (en) 2006-11-30 2009-06-23 Thermo Finnigan Llc Quadrupole FAIMS apparatus
GB0703578D0 (en) 2007-02-23 2007-04-04 Micromass Ltd Mass spectrometer
CN101067616B (zh) * 2007-06-06 2011-07-20 中国科学院合肥物质科学研究院 纵向高场不对称波形离子迁移谱装置

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2432255A (en) * 2005-11-10 2007-05-16 Micromass Ltd A mass spectrometer comprising an ion mobility separator
CN101416271A (zh) * 2006-05-22 2009-04-22 株式会社岛津制作所 平行板电极布置设备和方法
GB2443952A (en) * 2006-11-15 2008-05-21 Micromass Ltd Combined mass-to-charge ratio and charge state selection in tandem mass spectrometry

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Differential Mobility Separation of Ions Using a Rectangular Asymmetric Waveform;D. Papanastasiou等;《J. Phys. Chem. A》;20080101;第3638-3645页 *
Michael Guilhaus.Essential elements of time-of-flight mass spectrometry in combination with the inductively coupled plasma ion source.《 Spectrochimica Acta Part B》.2000, *

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CN105181781A (zh) 2015-12-23
US8610054B2 (en) 2013-12-17
WO2010125357A2 (en) 2010-11-04
JP5652473B2 (ja) 2015-01-14
GB0907619D0 (en) 2009-06-10
JP2012525672A (ja) 2012-10-22
US20120056085A1 (en) 2012-03-08
EP2425446B1 (en) 2015-07-01
CN102449727B (zh) 2015-09-09
WO2010125357A3 (en) 2011-01-06
EP2425446A2 (en) 2012-03-07
CN102449727A (zh) 2012-05-09

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