CN105169416A - Degradable soft tissue biopsy marker and preparation method thereof - Google Patents
Degradable soft tissue biopsy marker and preparation method thereof Download PDFInfo
- Publication number
- CN105169416A CN105169416A CN201510626215.9A CN201510626215A CN105169416A CN 105169416 A CN105169416 A CN 105169416A CN 201510626215 A CN201510626215 A CN 201510626215A CN 105169416 A CN105169416 A CN 105169416A
- Authority
- CN
- China
- Prior art keywords
- degradable
- preparation
- solution
- soft tissue
- tissue biopsy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention relates to a degradable soft tissue biopsy marker and a preparation method thereof. The marker is made of degradable biological materials or made by compounding the degradable biological materials with degradable metal. The marker is colored in surface and can be expanded to the size which is 3-6 times of the original size when the marker encounters water or body fluid. The marker is mainly used for positioning marking after breast cancer tissue biopsy.
Description
Technical field
The present invention relates to a kind of degradable soft tissue biopsy label.Belong to Biodegradable material field.Mainly solve the problem that current clinical middle occult breast cancer is difficult to be difficult in early discovery and clinical operation locate.
Background technology
The early diagnosis of breast carcinoma and early treatment are maintenance women natural forms, reduce the crux, particularly early diagnosis of mortality rate especially " most important thing ".But traditional diagnosis is mainly based on palpation, those are difficult to be found by palpation due to the occult breast cancer that position is dark, lump is too small or the reason such as low echo lump causes, thus have impact on treatment and the outcome of breast carcinoma.
Along with the progress of Imaging Technology, utilize high frequency ultrasound and nuclear-magnetism method can find breast tumor early completely, but the good degree that cancerates of tumor still need to be determined by pathological examination.It is negative that surgeon often can run into some physical palpations, but ultrasonic lower discovery mammary gland tumor or molybdenum target sheet have abnormal case, and a case ultrasonic examination sometimes can find multiple focus.How to process the focus be detected, which needs open surgical biopsy, and after biopsy, which needs to continue follow-up observation, and the pernicious or precancerous lesion detected is processed in time, and it is clinician's problem anxious to be resolved that the person that makes benign lesion again avoids unnecessary operation.In addition, because lump cannot touch, cause fail to pinpoint a disease in diagnosis, the probability of mistaken diagnosis increases, for post-operative also brings great difficulty, as lump is difficult to location, finds; Operating time may be longer; The tissue of more lump peripheries is not excised in excision entirely or blindly, causes unnecessary damage etc.
In recent years, along with digital three-dimensional stereotactic core needle biopsy systematic difference, location indwelling label biopsy breast carcinoma early discovery, clarify a diagnosis on there is important value.Needle localization technology not only can carry out biopsy by guided surgery exactly, and by indwelling label, location of operation can be provided convenient for further treating from now on.But, the biopsy sites label of current Clinical practice is all that non-degradation material is made, especially metal material wherein, be all adopt rustless steel, titanium, titanium alloy to make, no matter perform the operation the need of to biopsy sites from now on, all need post-operative to take out, can not in Preserving time body, particularly some sufferer needs postoperative continuation to observe, if do not carry out second operation taking-up label after end is observed, can cause potential risk and hidden danger to patient.
The progress of degradative bioactive material and degradable magnesium metal alkyl materials research and development technology, for Development of New Generation breast cancer tissue biopsy marker provides the foundation.By to the process of degradable biomaterial physicochemical processes, can not only make label can vivo degradation and also degradation time controlled, also label can be the several times of original volume and forms gel by Fast-swelling under can be made to have the infiltration of tissue fluid in vivo, fully fill the function of the residual cavity that sample of tissue stays, recovery organization form, digitized video inspection requirements can also be met, clearly can identify to provide convenience for treating further in the position of biopsy, simultaneously can also by the dyeing process to degradable biomaterial, enable surgeon's identification by color when carrying out necessary excision, be easy to conveniently, find the lesion locations of institute's labelling quickly, smooth location is also excised, thus minimizing operating time can be played, the unnecessary operation wound effect that the stripping of reduction blindness is found excision position and caused.According to clinical different requirement, if need to be used as the telltale mark after biopsy by metal developing, the degradable biomaterial bag through having dyeed also can be used by the magnesium-base metal crossed as metal marker thing.The compound biopsy marker prepared in this way, except having all functions of metal marker thing in the past, also has previously described many advantages concurrently.Therefore degradable soft tissue biopsy marker can be considered the regeneration product of existing Clinical practice product.
The present invention, as telltale mark target product after biopsy, has Biocompatibility good, can vivo degradation, to the characteristic of sound/optical signal sensitivity, different by specification, locates under can be applicable to high frequency ultrasound and nuclear-magnetism situation.Can in indwelling body after a period of time, degrade voluntarily, few intercurrent disease, accuracy rate of diagnosis is high.
Summary of the invention
The object of this invention is to provide a kind of can be used for carrying out in breast carcinoma sound/photoimaging diagnosis and treatment in soft tissue biopsy location with and colored, can the label of vivo degradation voluntarily.Its preparation process is as follows:
1, get collagen protein, fibroin albumen one or both, with the one of chitosan, chrondroitin, hyaluronic acid, Polyethylene Glycol, poly(hydrobutyl ester), polyvinyl alcohol, in the acid being dissolved in 0.1 ~ 0.5mol/L or ultra-pure water, be mixed with the solution that concentration is 0.1 ~ 10wt%, after froth in vacuum, leave standstill 24 hours.
2, the infusion configured is entered the deformable columnar mould prepared by silica gel, note during perfusion not producing bubble, then carry out lyophilizing.
3, repeatedly roll deformable mold with the pressure of 1-10kg after lyophilizing, the material in mould is tapered, becomes close.
4, the material rolled is placed within genipin solution 4-72 hour, dyes, after dyeing, take out cleaning, namely drying, packaging sterilizing prepared.
5, by pure magnesium or magnesium alloy, as the metals such as magnesium-zinc alloy, magnesium calcium alloy, magnesium zinc calcium alloy, magnesium zinc zircaloy prepare strip by machined, outer rim maximum gauge is 0.3-5.0mm, length is 3-20mm long strip shape object, shape, as spiral type, waveform, zigzag, spring shape etc., bakes sterilizing with ultrasonic cleaning is also dry.
6, by the deformable mold that infusion forward (FWD) good for aforementioned 1 Process configuration has the silica gel of self centering to prepare, note during perfusion not producing bubble, then by strip metal material insert mold center, after carry out lyophilizing.
7, repeatedly roll deformable mold with the pressure of 1-10kg after lyophilizing, the material in mould is tapered, becomes close.
8, be placed in by the material rolled and carry out painted in genipin solution 4-72 hour, namely painted rear taking-up cleaning, dry, packaging sterilizing have been prepared.
Detailed description of the invention
Embodiment one
Get being dissolved in the 0.1mol/L hydrochloric acid solution of 100ml of I-type collagen 1g and chitosan 1g, be mixed with the solution that concentration is 2wt%.24 hours are left standstill after de-bubble.Solution is slowly poured into the deformable columnar mould made into silica gel, then lyophilizing.After lyophilizing completes, repeatedly roll with the pressure of little type calender 2kg the dried frozen aquatic products be contained in mould, stop rolling when dried frozen aquatic products diameter is 2mm.The genipin solution of configuration 0.5%, puts into this solution 6 hours by the dried frozen aquatic products after rolling, prepares the dried frozen aquatic products with yellow color, rear cleaning 5 times, and dry roasting sterilizing, packaging sterilizing after pruning, preparation completes.
Embodiment two
Get I-type collagen and each 2g of fibroin albumen is dissolved in the 0.5mol/L acetum of 100ml, then get chitosan 0.2g and be dissolved in above-mentioned solution, be mixed with the solution that concentration is 4.2wt%.24 hours are left standstill after de-bubble.Solution is slowly poured into the deformable columnar mould made into silica gel, then lyophilizing.After lyophilizing completes, repeatedly roll with the pressure of little type calender 1kg and be contained in mould dried frozen aquatic products, stop rolling when dried frozen aquatic products diameter is 1mm.The genipin solution of configuration 0.3%, puts into this solution 12 hours by the dried frozen aquatic products after rolling, prepares with dried frozen aquatic products azury, rear cleaning 5 times, and dry roasting sterilizing, packaging sterilizing after pruning, preparation completes.
Embodiment three
Get type III collagen protein 9g to be dissolved in the 0.1mol/L phosphoric acid solution of 100ml, then get being dissolved in above-mentioned solution of polyvinyl alcohol 0.5g, be mixed with the solution that concentration is 9.5wt%.24 hours are left standstill after de-bubble.Solution is slowly poured into the deformable columnar mould made into silica gel, then lyophilizing.After lyophilizing completes, repeatedly roll with the pressure of little type calender 5kg and be contained in mould dried frozen aquatic products, stop rolling when dried frozen aquatic products diameter is 1.5mm.The genipin solution of configuration 0.5%, puts into this solution 48 hours by the dried frozen aquatic products after rolling, prepares the dried frozen aquatic products with blue color, rear cleaning 5 times, and dry roasting sterilizing, packaging sterilizing after pruning, preparation completes.
Embodiment four
Get II collagen type collagen 5g and fibroin albumen 2g to be dissolved in the 0.1mol/L citric acid of 100ml, then being dissolved in above-mentioned solution of taking polyethylene glycol 1g, be mixed with the solution that concentration is 8wt%.24 hours are left standstill after froth in vacuum.Solution is slowly poured into the deformable columnar mould made into silica gel, then lyophilizing.After lyophilizing completes, repeatedly roll with the pressure of little type calender 1kg and be contained in mould dried frozen aquatic products, stop rolling when dried frozen aquatic products diameter is 1mm.The genipin solution of configuration 0.4%, puts into this solution 72 hours by the dried frozen aquatic products after rolling, prepares the dried frozen aquatic products with black color, rear cleaning 5 times, and dry roasting sterilizing, packaging sterilizing after pruning, preparation completes.
Embodiment five
Get powdery type III collagen protein collagen 8g to be slowly dissolved in the ultra-pure water solution of 100ml, then get being dissolved in above-mentioned solution of hyaluronic acid 1g, be mixed with the solution that concentration is 9wt%.24 hours are left standstill after de-bubble.Solution is slowly poured into the deformable columnar mould made into silica gel, then lyophilizing.After lyophilizing completes, repeatedly roll with the pressure of little type calender 2kg and be contained in mould dried frozen aquatic products, stop rolling when dried frozen aquatic products diameter is 2mm.The genipin solution of configuration 0.3%, puts into this solution 12 hours by the dried frozen aquatic products after rolling, prepares with dried frozen aquatic products azury, rear cleaning 5 times, and dry roasting sterilizing, packaging sterilizing after pruning, preparation completes.
Embodiment six
Cut-off footpath is the pure magnesium wire rod of 4mm, becomes that diameter is 1.5mm, length is the threaded bar of 10mm with lathe process.By threaded bar purified water ultrasonic cleaning 5 also dry roasting sterilizings.Get being dissolved in the 0.5mol/L hydrochloric acid solution of 100ml of I-type collagen 5g and chitosan 1g, be mixed with the solution that concentration is 6wt%.24 hours are left standstill after de-bubble.Solution is slowly poured into into silica gel make deformable self centering columnar mould in, after threaded bar is inserted in the centre bore of mould, then lyophilizing.After lyophilizing completes, repeatedly roll with the pressure of little type calender 2kg and be contained in mould dried frozen aquatic products, stop rolling when dried frozen aquatic products diameter is 2mm.The genipin solution of configuration 0.5%, puts into this solution 56 hours by the dried frozen aquatic products after rolling, prepares the dried frozen aquatic products with blue color, rear cleaning 5 times, and dry roasting sterilizing, packaging sterilizing after pruning, preparation completes.
Embodiment seven
Cut-off footpath is two, 0.5mm Magnesium calcium alloy tinsel, clamp two one metal wires with lathe one section, slow uniform rotation lathe dog, prepare the twisted shape tinsel that two one metal wires are woven together, maximum outer eaves diameter is 1mm, this twisted shape tinsel of intercepted length 15mm, with purified water ultrasonic cleaning 5 also dry roasting sterilizings.Get being dissolved in the 0.1mol/L acetum of 100ml of I-type collagen 5g and fibroin albumen 1g, then being dissolved in above-mentioned solution of taking polyethylene glycol 1g, be mixed with the solution that concentration is 7wt%.24 hours are left standstill after de-bubble.Solution is slowly poured into into silica gel make deformable self centering columnar mould in, after by twisted shape tinsel insert mould centre bore in, then lyophilizing.After lyophilizing completes, repeatedly roll with the pressure of little type calender 2kg and be contained in mould dried frozen aquatic products, stop rolling when dried frozen aquatic products diameter is 1.5mm.The genipin solution of configuration 0.5%, puts into this solution 72 hours by the dried frozen aquatic products after rolling, prepares the dried frozen aquatic products with blue color, rear cleaning 5 times, and dry roasting sterilizing, packaging sterilizing after pruning, preparation completes.
Embodiment eight
Cut-off footpath is one, 0.8mm Magnesium zinc calcium alloy tinsel, with with the slow extrusion metal silk of corrugated mould, prepare the wavy tinsel that maximum outer eaves diameter is 1.2mm, this tinsel of intercepted length 12mm, with purified water ultrasonic cleaning 5 also dry roasting sterilizings.Get powdery type III collagen protein collagen 5g to be slowly dissolved in the ultra-pure water solution of 100ml, then get being dissolved in above-mentioned solution of poly(hydrobutyl ester) 2g, be mixed with the solution that concentration is 7wt%, after de-bubble, leave standstill 24 hours.Solution is slowly poured in the columnar mould of the deformable self centering made into silica gel, after wavy tinsel is inserted in the centre bore of mould, then lyophilizing.After lyophilizing completes, repeatedly roll with the pressure of little type calender 1kg and be contained in mould dried frozen aquatic products, stop rolling when dried frozen aquatic products diameter is 1.5mm.The genipin solution of configuration 0.3%, puts into this solution 48 hours by the dried frozen aquatic products after rolling, prepares the dried frozen aquatic products with blue color, rear cleaning 5 times, and dry roasting sterilizing, packaging sterilizing after pruning, preparation completes.
Embodiment nine
Cut-off footpath is one, 2mm Magnesium zinc zircaloy tinsel, with lathe process become as dumbbell shaped, maximum outer eaves diameter be 1.2mm, length is the metal stub of 12mm, dryly bakes sterilizing with this stub of purified water ultrasonic cleaning 5 times.Get II collagen type collagen 8g to be slowly dissolved in the 0.1mol/L citric acid solution of 100ml, then get being dissolved in above-mentioned solution of hyaluronic acid 2g, be mixed with the solution that concentration is 10wt%, after de-bubble, leave standstill 24 hours.Solution is slowly poured into into silica gel make deformable self centering columnar mould in, after by dumbbell shaped metal stub insert mould centre bore in, then lyophilizing.After lyophilizing completes, repeatedly roll with the pressure of little type calender 3kg and be contained in mould dried frozen aquatic products, stop rolling when dried frozen aquatic products diameter is 1.5mm.The genipin solution of configuration 0.5%, puts into this solution 48 hours by the dried frozen aquatic products after rolling, prepares the dried frozen aquatic products with blue color, rear cleaning 5 times, and dry roasting sterilizing, packaging sterilizing after pruning, preparation completes.
Embodiment ten
Cut-off footpath is one, 0.3mm Magnesium zinc calcium alloy tinsel, is processed into special purpose spring process equipment the metal spring silk that diameter is 1mm, length is 12mm, with 5 the also dry roasting sterilizings of this spring wire of purified water ultrasonic cleaning.Get I-type collagen 5g to be slowly dissolved in the 0.3mol/L lactic acid solution of 100ml, then get polyvinyl alcohol 1g and be dissolved in above-mentioned solution, be mixed with the solution that concentration is 6wt%, after de-bubble, leave standstill 24 hours.This solution is slowly poured into into silica gel make deformable self centering columnar mould in, after wire of spring is inserted in the centre bore of mould, then lyophilizing.After lyophilizing completes, repeatedly roll with the pressure of little type calender 3kg and be contained in mould dried frozen aquatic products, stop rolling when dried frozen aquatic products diameter is 1.5mm.The genipin solution of configuration 0.5%, puts into this solution 72 hours by the dried frozen aquatic products after rolling, prepares the dried frozen aquatic products with blue color, rear cleaning 5 times, and dry roasting sterilizing, packaging sterilizing after pruning, preparation completes.
Claims (7)
1. degradable soft tissue biopsy label and preparation method thereof, is characterized in that, it is by degradable biomaterial or/and degradable metal Material cladding is prepared from, and its appearance is yellow or the strip object of a kind of color of brown or blueness or black.
2. a kind of degradable soft tissue biopsy label according to claim 1 and preparation method thereof, after it is characterized in that it and water or bioresorbable volume can expand for original volume 3-6 doubly.
3. a kind of degradable soft tissue biopsy label according to claim 1 and preparation method thereof, when it is made up of degradable biomaterial, is characterized in that:
(1) degradable biomaterial composition is made up of the one of protein and polysaccharide/Polyethylene Glycol/poly(hydrobutyl ester)/polyvinyl alcohol, and wherein the mass ratio of protein and polysaccharide/Polyethylene Glycol/poly(hydrobutyl ester)/polyvinyl alcohol compound is 1 ~ 9: 9 ~ 1;
(2) protein described in (1) is collagen protein, fibroin albumen.When collagen protein and fibroin albumen compound use, mass ratio is 9 ~ 5: 1 ~ 5;
(3) its shape is diameter is 0.5-6.0mm, and length is the strip object of 3-30mm.
4. a kind of degradable soft tissue biopsy label according to claim 1 and preparation method thereof, when it is made up of degradable biomaterial and degradable metal Material cladding, is characterized in that:
(1) biodegradation material composition is made up of the one of protein and polysaccharide/Polyethylene Glycol/poly(hydrobutyl ester)/polyvinyl alcohol, and wherein the mass ratio of protein and polysaccharide/Polyethylene Glycol/poly(hydrobutyl ester)/polyvinyl alcohol compound is 1 ~ 9: 9 ~ 1;
(2) protein described in (1) is collagen protein, fibroin albumen.When prepared by collagen protein and fibroin albumen compound, mass ratio is 9 ~ 5: 1 ~ 5;
(3) degradable metal material is the one of magnesium, magnesium alloy, and its shape is long strip type, and outer rim maximum gauge is 0.3-5.0mm, and length is 3-20mm long strip shape object;
(4) degradable biomaterial and metal material complex form are that degradable biomaterial is wrapped in the outside of metal material, and its shape is outer eaves diameter is 0.5-6.0mm, and length is the strip object of 3.5-30mm.
5. a kind of degradable soft tissue biopsy label according to claim 1 and preparation method thereof, is characterized in that coloring agent is genipin.
6. a kind of degradable soft tissue biopsy label according to claim 3 and preparation method thereof, is characterized in that its preparation method is:
(1) degradable biomaterial will prepared by the mass ratio described in claim 3, the solution that concentration is 0.1 ~ 10wt% is dissolved into one of acid or ultra-pure water, and this solution for vacuum de-bubble is also left standstill 24 hours, also lyophilizing in the deformable columnar mould of silica gel making is entered in rear fill:
(2) repeatedly roll with the pressure of 1 ~ 10kg and completed lyophilizing but the material be still contained in deformable mold, then taken out from mould by the material rolled and use coloring agent painted, namely cleaning after painted 4 ~ 72 hours, drying, packaging, sterilizing have been prepared.
7. a kind of degradable soft tissue biopsy label according to claim 4 and preparation method thereof, is characterized in that its preparation method is:
(1) by by the degradable metal material shaped strip object of mach method described by claim 4, such as: screw-like, wavy, zigzag, I-shaped shape etc., with purified water ultrasonic cleaning also dry roasting sterilizing;
(2) degradable biomaterial will prepared by the mass ratio described by claim 4, the solution that concentration is 0.1 ~ 10wt% is dissolved into acid or a kind of of ultra-pure water, and this solution for vacuum de-bubble is also left standstill 24 hours, then filled with solution is entered deformable, can in the columnar mould of self centering, and strip metal material is inserted mold center, then lyophilizing;
(3) repeatedly roll with the pressure of 1 ~ 10kg and completed lyophilizing but the material be still contained in deformable mold, then taken out from mould by the material rolled and use coloring agent painted, namely cleaning after painted 4 ~ 72 hours, drying, packaging, sterilizing have been prepared.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510626215.9A CN105169416A (en) | 2015-09-18 | 2015-09-18 | Degradable soft tissue biopsy marker and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510626215.9A CN105169416A (en) | 2015-09-18 | 2015-09-18 | Degradable soft tissue biopsy marker and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105169416A true CN105169416A (en) | 2015-12-23 |
Family
ID=54892158
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510626215.9A Pending CN105169416A (en) | 2015-09-18 | 2015-09-18 | Degradable soft tissue biopsy marker and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105169416A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106491215A (en) * | 2016-10-26 | 2017-03-15 | 河南省肿瘤医院 | Disposable sterilized positioning fixture |
| CN112274263A (en) * | 2020-11-05 | 2021-01-29 | 汤小江 | Bioabsorbable mammary tissue positioning mark clamp and preparation method thereof |
| CN115531618A (en) * | 2022-10-18 | 2022-12-30 | 苏州茵络医疗器械有限公司 | Degradable anchoring device for nodule marker positioning and preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104856759A (en) * | 2015-03-26 | 2015-08-26 | 深圳市人民医院 | Multimode mammary gland developing target and dedicated device for releasing target |
-
2015
- 2015-09-18 CN CN201510626215.9A patent/CN105169416A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104856759A (en) * | 2015-03-26 | 2015-08-26 | 深圳市人民医院 | Multimode mammary gland developing target and dedicated device for releasing target |
Non-Patent Citations (3)
| Title |
|---|
| 李令锦等: "京尼平对丝素蛋白交联的染色作用", 《应用与环境生物学报》 * |
| 李萌等: "中国介入影像与治疗学", 《乳腺影像学靶标的应用及研究进展》 * |
| 陶海荣等: "镁锌合金在动物体内降解及其相容性", 《中国组织工程研究与临床康复》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106491215A (en) * | 2016-10-26 | 2017-03-15 | 河南省肿瘤医院 | Disposable sterilized positioning fixture |
| CN112274263A (en) * | 2020-11-05 | 2021-01-29 | 汤小江 | Bioabsorbable mammary tissue positioning mark clamp and preparation method thereof |
| CN115531618A (en) * | 2022-10-18 | 2022-12-30 | 苏州茵络医疗器械有限公司 | Degradable anchoring device for nodule marker positioning and preparation method and application thereof |
| CN115531618B (en) * | 2022-10-18 | 2023-11-21 | 苏州茵络医疗器械有限公司 | Degradable anchoring device for nodule marking and positioning and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10045832B2 (en) | Marker or filler forming fluid | |
| US11819648B2 (en) | Methods and devices to prevent premature birth | |
| CA2483580C (en) | Biodegradable polymer for marking tissue and sealing tracts | |
| JP7146214B2 (en) | Multimode imaging marker | |
| JP2003503098A (en) | Biopsy position marker and process and apparatus for applying the same | |
| CN105169416A (en) | Degradable soft tissue biopsy marker and preparation method thereof | |
| JP2005312941A (en) | Device and method for marking tissue | |
| CN107835672B (en) | Surgical system and method of use | |
| CN107427612A (en) | Degradable medical treatment device on demand | |
| CN109692045A (en) | A kind of degradable soft tissue biopsy marker | |
| CN105169495A (en) | Preparation method of degradable metal guide wires for breast cancer sound-light imaging diagnosis and treatment | |
| CN109793900A (en) | A kind of preparation method applied to degradable marker in breast cancer imaging modalities | |
| CN108785755A (en) | Application of the magnesium alloy in preparing degradable biliary tract rack | |
| CN108066825A (en) | A kind of preparation method of medical flexible gradual change vessel catheter | |
| CN104744723B (en) | Chitosan medical material and its preparation method and application | |
| CN106913899A (en) | Plant polyose styptic sponge is prepared using secondary freezing | |
| JP2006254929A (en) | Antiadhesive material | |
| CN105999434A (en) | Developing type degradable ureter repairing stent | |
| CN109288622A (en) | A kind of conduit with tissue protective outer embrane, preparation method and application | |
| CN105902306B (en) | Endometrium prosthetic device | |
| CN109793942A (en) | A kind of magnesium and magnesium alloy medical material that good biocompatibility can degrade in vivo | |
| CN109621016A (en) | A kind of biology, which prevents adhesion, repairs auxiliary material and preparation method thereof | |
| CN109692366A (en) | A kind of preparation method of degradable metal seal wire | |
| CN109692365A (en) | A kind of wire guide applied to breast cancer treatment | |
| CN109692364A (en) | It is a kind of for sound, the Biodegradable material of light imaging modalities |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20151223 |