CN105169495A - Preparation method of degradable metal guide wires for breast cancer sound-light imaging diagnosis and treatment - Google Patents
Preparation method of degradable metal guide wires for breast cancer sound-light imaging diagnosis and treatment Download PDFInfo
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- CN105169495A CN105169495A CN201510626214.4A CN201510626214A CN105169495A CN 105169495 A CN105169495 A CN 105169495A CN 201510626214 A CN201510626214 A CN 201510626214A CN 105169495 A CN105169495 A CN 105169495A
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- tinsel
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Abstract
The invention provides positioning metal guide wires for breast cancer sound-light imaging diagnosis and treatment, and belongs to biological degradable materials. The problems that in the clinical application at present, occult breast cancer is difficult to find and positioning is difficult in a clinical operation are mainly solved. Implants can be degraded in a certain period of time, and meanwhile foreign objects in a human body can not be formed.
Description
Technical field
The present invention relates to a kind of positioning metal seal wire that can be used in breast carcinoma sound/photoimaging diagnosis and treatment.Belong to Biodegradable material.Mainly solve the problem that current clinical middle occult breast cancer is difficult to be difficult in early discovery and clinical operation locate.
Background technology
The early diagnosis of breast carcinoma and early treatment be reduce mortality rate key, particularly early diagnosis especially " most important thing ".But traditional diagnosis is mainly based on palpation, those are difficult to be found by palpation due to the occult breast cancer that position is deeply too small at, lump or the reason such as low echo lump causes, thus have impact on treatment and the outcome of breast carcinoma.
Along with the progress of Imaging Technology; utilize high frequency ultrasound and nuclear-magnetism method can find breast tumor early completely; but the good degree that cancerates of tumor still needs to be determined by pathological examination; it is negative that surgeon often can run into some physical palpations; but ultrasonic lower discovery mammary gland tumor or molybdenum target sheet have abnormal case, a case ultrasonic examination sometimes can find multiple focus.How to process the focus be detected, which needs open surgical biopsy, and which needs to continue follow-up observation, and the pernicious or precancerous lesion detected is processed in time, and it is clinician's problem anxious to be resolved that the person that makes benign lesion again avoids unnecessary operation.Because lump cannot touch, cause fail to pinpoint a disease in diagnosis, the probability of mistaken diagnosis increases, and also brings great difficulty, as lump is difficult to location, finds to post-operative; Operating time may be longer; The tissue of more lump peripheries is not excised in excision entirely or blindly, causes unnecessary damage etc.
In recent years, along with digital three-dimensional stereotactic core needle biopsy systematic difference, location indwelling seal wire biopsy breast carcinoma early discovery, clarify a diagnosis on there is important value.The bootable surgical biopsy of Needle localization technology accurately, outer by swelling formation gel under the effect of collagen tissue fluid in vivo, and fill the residual cavity that sample of tissue stays, while making the not direct contact tissue of seal wire, guarantee that fixing seal wire by sound/optical detection, can be metal object because of seal wire and have barb, easily lay one's hand in art and, reduce unnecessary mammary gland infringement, make excision extension more accurate.This sound of rower in art/illumination phase, avoids and leakage cuts and the problem such as aspiration biopsy false negative.
But current commercially available seal wire product, all needs post-operative to take out, can not in indwelling body, particularly some sufferer needs clinical follow, must carry out second operation, also exist sometimes because operation carelessness causes the situation of foreign body indwelling to exist.And the present invention implants target product as location, there is Biocompatibility good, can vivo degradation, to characteristics such as sound/optical signal are responsive, different by specification, locate under can be applicable to high frequency ultrasound and nuclear-magnetism situation.Can in indwelling body after a period of time, degrade voluntarily, few intercurrent disease, accuracy rate of diagnosis is high.
Summary of the invention
The object of this invention is to provide a kind of positioning metal seal wire product that can be used in breast carcinoma sound/photoimaging diagnosis and treatment.Its preparation process is as follows:
1, one of commercial metals magnesium, magnalium, magnesium-rare earth, magnesium manganese alloy, magnesium calcium alloy, mg-si master alloy, magnesia-chrome, magnesium metal, ferromanganese is got, be machined to (0.5 ~ 1cm) × Φ (0.2 ~ 0.4mm) tinsel, and be drawn into helical form;
2, in one of commercially available collagen, chitosan, Polyethylene Glycol, poly(hydrobutyl ester), the polyvinyl alcohol hydrochloric acid that is dissolved in 0.001 ~ 0.1mol/L or ultra-pure water, the solution that concentration is 1 ~ 10wt% is mixed with;
3, one of the bioluminescence albumen of emission spectra between 400 ~ 800nm, methine class cyanine dye, coumarine dye, reactive amines dyestuff of 10 ~ 1000 μ g is added in solution;
4, stir, load in syringe, after tinsel is placed in mould, the indigo plant dye solution in syringe is pushed in mould, until fill up;
5, the mould filled up is inserted in UV-crosslinked instrument, with the ultraviolet irradiation of 280 ~ 357nm to Material shrinkage drying;
6, material is after cutting out and repairing, packaging sterilizing;
Detailed description of the invention
Embodiment one
Commercial metals magnesium is processed into the tinsel of 0.5cm × Φ 0.2mm, and commercially available collagen 3mg is dissolved in the 0.001mol/L hydrochloric acid solution of 100ml, is mixed with the solution that concentration is 3wt%.Add the bioluminescence albumen that 10 μ g emission spectra are 560nm in solution, after injecting mould, add tinsel, ultraviolet 280nm is irradiated to Material shrinkage drying, packaging sterilizing after pruning.
Embodiment two
Commercially available magnalium is processed into the tinsel of 0.8cm × Φ 0.3mm, and commercially available chitosan 3mg is dissolved in the 0.1mol/L hydrochloric acid solution of 100ml, is mixed with the solution that concentration is 3wt%.Add the three methine cyanine dyes that 100 μ g emission spectra are 525nm in solution, after injecting mould, add tinsel, ultraviolet 280nm is irradiated to Material shrinkage drying, packaging sterilizing after pruning.
Embodiment three
Commercially available magnesium-rare earth is processed into the tinsel of 0.1cm × Φ 0.4mm, and commercially available Polyethylene Glycol 5mg is dissolved in the ultra-pure water of 100ml, is mixed with the solution that concentration is 5wt%.Add the five methine cyanine dyes that 200 μ g emission spectra are 610nm in solution, after injecting mould, add tinsel, ultraviolet 357nm is irradiated to Material shrinkage drying, packaging sterilizing after pruning.
Embodiment four
The violent alloy of commercially available magnesium zinc is processed into the tinsel of 1cm × Φ 0.2mm, and commercially available poly(hydrobutyl ester) 10mg is dissolved in the ultra-pure water of 100ml, is mixed with the solution that concentration is 10wt%.Add the reactive amines dyestuff that 400 μ g emission spectra are 715nm in solution, after injecting mould, add tinsel, ultraviolet 357nm is irradiated to Material shrinkage drying, packaging sterilizing after pruning.
Embodiment five
Commercially available magnesium calcium alloy is processed into the tinsel of 0.6cm × Φ 0.3mm, and commercial polyethylene alcohol 1mg is dissolved in the ultra-pure water of 100ml, is mixed with the solution that concentration is 1wt%.Adding 800 μ g emission spectra in solution is the coumarine dye of 650nm, and after injecting mould, add tinsel, ultraviolet 357nm is irradiated to Material shrinkage drying, packaging sterilizing after pruning.
Embodiment six
Commercially available mg-si master alloy is processed into the tinsel of 0.7cm × Φ 0.2mm, and commercially available collagen 2mg is dissolved in the 0.01mol/L hydrochloric acid solution of 100ml, is mixed with the solution that concentration is 2wt%.Adding 600 μ g emission spectra in solution is the coumarine dye of 410nm, and after injecting mould, add tinsel, ultraviolet 280nm is irradiated to Material shrinkage drying, packaging sterilizing after pruning.
Embodiment seven
Commercially available magnesia-chrome is processed into the tinsel of 0.9cm × Φ 0.3mm, and commercial polyethylene alcohol 7mg is dissolved in the ultra-pure water of 100ml, is mixed with the solution that concentration is 7wt%.Adding 1000 μ g emission spectra in solution is the heptamethine cyanine of 775nm, and after injecting mould, add tinsel, ultraviolet 280nm is irradiated to Material shrinkage drying, packaging sterilizing after pruning.
Embodiment eight
Commercially available magnesium metal is processed into the tinsel of 1cm × Φ 0.4mm, and commercial polyethylene alcohol 1mg is dissolved in the ultra-pure water of 100ml, is mixed with the solution that concentration is 1wt%.Add the reactive amines dyestuff that 300 μ g emission spectra are 581nm in solution, after injecting mould, add tinsel, ultraviolet 280nm is irradiated to Material shrinkage drying, packaging sterilizing after pruning.
Embodiment nine
Commercially available ferromanganese is processed into the tinsel of 1cm × Φ 0.3mm, and commercially available Polyethylene Glycol 8mg is dissolved in the ultra-pure water of 100ml, is mixed with the solution that concentration is 8wt%.Add the reactive amines dyestuff that 500 μ g emission spectra are 550nm in solution, after injecting mould, add tinsel, ultraviolet 357nm is irradiated to Material shrinkage drying, packaging sterilizing after pruning.
Claims (8)
1. for the wire guide in breast carcinoma sound/photoimaging diagnosis and treatment, formed by outsourcing tegillum and tinsel bag, outward appearance is the stub of (1 ~ 2cm) × Φ (1 ~ 2mm).
2. outsourcing tegillum according to claim 1 is one of the collagen, chitosan, Polyethylene Glycol, poly(hydrobutyl ester), polyvinyl alcohol through blue transfection reagent process.
3. tinsel material according to claim 1 is one of magnesium metal, magnalium, magnesium-rare earth, magnesium manganese alloy, magnesium calcium alloy, mg-si master alloy, magnesia-chrome, magnesium metal, ferromanganese.
4. according to claim 1, wrapping is injected with after mould wiry by outsourcing tegillum solution, and the ultraviolet-crosslinkable through 280 ~ 357nm forms.
5. blue transfection reagent according to claim 2 comprise be stimulated after can the bioluminescence albumen of emission spectra between 400 ~ 800nm, methine class cyanine dye, coumarine dye, one of reactive amines dyestuff.
6. outsourcing tegillum solution concentration according to claim 4 is 1 ~ 10wt%.
7. the solvent of solution is one of the hydrochloric acid or ultra-pure water of 0.001 ~ 0.1mol/L according to claim 6.
8. dye dosage is 10 ~ 1000 μ g according to claim 9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510626214.4A CN105169495A (en) | 2015-09-18 | 2015-09-18 | Preparation method of degradable metal guide wires for breast cancer sound-light imaging diagnosis and treatment |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510626214.4A CN105169495A (en) | 2015-09-18 | 2015-09-18 | Preparation method of degradable metal guide wires for breast cancer sound-light imaging diagnosis and treatment |
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| CN105169495A true CN105169495A (en) | 2015-12-23 |
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| CN201510626214.4A Pending CN105169495A (en) | 2015-09-18 | 2015-09-18 | Preparation method of degradable metal guide wires for breast cancer sound-light imaging diagnosis and treatment |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106491215A (en) * | 2016-10-26 | 2017-03-15 | 河南省肿瘤医院 | Disposable sterilized positioning fixture |
| CN107998395A (en) * | 2017-12-14 | 2018-05-08 | 天津市赛宁生物工程技术有限公司 | A kind of difunctional mammary gland target and preparation method |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050058652A1 (en) * | 1997-01-13 | 2005-03-17 | Mayers George L. | Method and composition for the treatment of cancer by the enzymatic conversion of soluble radioactive toxic precipitates in the cancer |
| CN102590176A (en) * | 2012-03-01 | 2012-07-18 | 中国科学院苏州纳米技术与纳米仿生研究所 | Surface-enhanced Raman scattering probe and preparation method thereof |
| CN104856759A (en) * | 2015-03-26 | 2015-08-26 | 深圳市人民医院 | Multimode mammary gland developing target and dedicated device for releasing target |
-
2015
- 2015-09-18 CN CN201510626214.4A patent/CN105169495A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050058652A1 (en) * | 1997-01-13 | 2005-03-17 | Mayers George L. | Method and composition for the treatment of cancer by the enzymatic conversion of soluble radioactive toxic precipitates in the cancer |
| CN102590176A (en) * | 2012-03-01 | 2012-07-18 | 中国科学院苏州纳米技术与纳米仿生研究所 | Surface-enhanced Raman scattering probe and preparation method thereof |
| CN104856759A (en) * | 2015-03-26 | 2015-08-26 | 深圳市人民医院 | Multimode mammary gland developing target and dedicated device for releasing target |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106491215A (en) * | 2016-10-26 | 2017-03-15 | 河南省肿瘤医院 | Disposable sterilized positioning fixture |
| CN107998395A (en) * | 2017-12-14 | 2018-05-08 | 天津市赛宁生物工程技术有限公司 | A kind of difunctional mammary gland target and preparation method |
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