CN105168666A - Composition for improving pancreatitis and preparation method thereof - Google Patents
Composition for improving pancreatitis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a composition for improving pancreatitis. The composition for improving the pancreatitis comprises active pharmaceutical ingredients and matrices, wherein the active pharmaceutical ingredients are prepared from, by weight, 10-30 parts of sargentgloryvine stems, 15-25 parts of hawthorns, 15-25 parts of angelica sinensis, 5-15 parts of brooklet anemine roots, 8-16 parts of black tea, 5-15 parts of radix aristolochiae, 5-15 parts of rhizoma corydalis, 4-12 parts of honeysuckle flowers, 20-40 parts of bananas, 2-8 parts of concha arcae and 10-15 parts of black sesame. The composition for improving the pancreatitis is based on the principle of disease distinguishing and preventing through traditional Chinese medicine dressing, the formula is scientific, symptoms and root causes are both treated, side effects do not exist, safety and effectiveness are achieved, drug administration is convenient, the defects that traditional Chinese medicine and western medicine are difficult to swallow, and children do not cooperate are avoided, and the pancreatitis can be effectively improved.
Description
Technical field
The invention discloses one and treat colpitic compositions, especially the pancreatitic composition and method of making the same of a kind of improvement, the invention belongs to traditional Chinese medicine field.
Background technology
Pancreatitis is the disease that pancreas causes because of tryptic autodigestion effect.Pancreas has edema, hyperemia, or hemorrhage, downright bad.There is the symptom such as stomachache, abdominal distention, Nausea and vomiting, heating clinically.Blood test and amylase content rising in urine etc.
The cause of disease: under normal circumstances, the pancreatin of pancreatic juice containing non-activity in its gland tissue is former.Pancreatic juice constantly flows into duodenum through common bile duct Oddi's sphincter along pancreas pipeline, exist owing to there being bile in duodenum, add that duodenal wall mucosa secretes a kind of enterokinase, under the effect of the two, the former beginning of pancreatin is transformed into active very strong digestive enzyme.If efferent tract is obstructed, drainage difficulty, can cause pancreatitis.When Oddi's sphincter spasm or gallbladder overpressure raise, as calculus, carcinomatous obstruction, bile reflux can enter ductus pancreaticus and enters pancreatic tissue, now, lecithin contained in bile is decomposed into LYSOLECITHIN SUNLECITHIN A by A lecithinase contained in pancreatic juice, can produce toxic action to pancreas.Or during biliary tract infection, antibacterial can discharge kinases and be activated by pancreatin, become the active substance that can damage and dissolve pancreatic tissue equally.These materials change into trypsin by former for pancreatin contained in pancreatic juice, and this enzymic digestion is active strong, infiltrates through pancreatic tissue and causes autodigestion, also can cause pancreatitis.1. acute pancreatitis: be trypsinization pancreas and the acute inflammation caused by surrounding tissue thereof is main manifestations to be pancreas be edema, hemorrhage and downright bad.Below pathogenic factor is common: the pathological changes such as (1) biliary tract disease bile duct inflammation, calculus, parasite, edema, spasm makes ampulla block, and bile enters ductus pancreaticus by shared pathway reflux, activates pancreatin former, thus cause pancreatitis.(2) excessive drinking and eating and drinking too much at one meal are indulged in excessive drinking and eating and drinking too much at one meal makes pancreatic secretion vigorous, and ductus pancreaticus inadequate drainage, cause pancreatic juice to increase at the pressure of pancreatic duct system, cause the protease acatharsia of high concentration, finally cause pancreas follicular rupture and fall ill.(3) operation is expressed to pancreas with abdominal operation such as damage stomach, biliary tract etc., or causes pancreatic duct hypertonia.(4) infecting a lot of infectious disease can analyses of complicating acute pancreatitis, and how not obvious symptom is.As ascarid enters bile duct or ductus pancreaticus, can antibacterial be brought into, pancreatin can be made to activate and cause pancreas inflammatory.(5) hyperlipemia and hypercalcemia hyperlipemia, fat embolism pancreas blood vessel causes ischemia, telangiectasis, infringement blood vessel wall, causes pancreatic juice to drain difficulty; Calculus can block ductus pancreaticus, causes pancreatitis.2. chronic pancreatitis: due to the disease of a kind of pancreas chronic progressive external destruction that acute pancreatitis recurrent exerbation causes.
Clinical manifestation: 1. have eating and drinking too much at one meal or biliary tract history before acute pancreatitis outbreak more.Acute pancreatitis can be divided into plain edition and hemorrhagic necrosis type.Hemorrhagic necrosis type is more rare, but is in a bad way, and mortality rate is high.(1) shock patients often occurs that shock symptom is as pale, cold sweat, thready pulse, blood pressure drops etc., causes the reason of shock to have multiple, as due to pancreatic juice excessive, stimulate peritoneum to cause and have an intense pain; Pancreatic tissue and intraperitoneal hemorrhage; Tissue necrosis, the body that breaks down proteins causes is poisoning.Shock severe patient rescues not in time can be lethal.(2) stomachache stomachache is often arranged in epigastrium, be that band shape radiates sometimes, to bend over or the seat that leans forward can alleviate to lower back; Often break out after heavy drinking or heavy meal, degree varies, the lighter is dull pain, and severe one is many in persistence angor.(3) namely Nausea and vomiting most of patients onset vomits gastric content, even vomits bile, tells rear stomachache and does not alleviate.(4) most patients with acute pancreatitis of generating heat occurs that moderate is generated heat, and generally continues 3 ~ 5 days.(5) Water-Electrolyte and acid base imbalance patient have dehydration in various degree, and frequent vomiter metabolic alkalosis can occur, and severe pancreatitis is often with metabolic acidosis, hypocalcemia, blood glucose rising, hypokalemia, hypomagnesemia.2. chronic pancreatitis
(1) multidigit of suffering from abdominal pain is in epigastrium, and disperse, can be radiated to back, both sides of the chest, sits up or leans forward and alleviate to some extent.(2) pancreatic insufficiency indigestion symptom in various degree as abdominal distention, poor appetite, detest oil, become thin, steatorrhea etc.; Half patient is because endocrine dysfunction generation diabetes.(3) the slight chronic pancreatitis of sign seldom has positive sign, and some cases has upper abdomen mild tenderness; Advanced chronic pancreatitis because of steatorrhea can nutritious bad performance; If acute attack, then to the upper abdomen tenderness of severe in can occurring.
Authorization Notice No. CN102920910B(application number 201210474560.1) Chinese patent literature disclose a kind of Chinese medicine for the treatment of chronic pancreatitis, it is characterized in that, be prepared from by the medical material of following weight proportion: Rhizoma Chuanxiong 12 parts, Oletum Trogopterori 10 parts, Myrrha 12 parts, Caulis Spatholobi 10 parts, Radix Achyranthis Bidentatae 12 parts, Fructus Leonuri 12 parts, 10 parts, golden waist, Radix Angelicae Sinensis 14 parts, Radix Polygoni Multiflori 14 parts, Bulbus Lilii 12 parts, Radix Asparagi 12 parts, Rhizoma Polygonati Odorati 10 parts.Authorization Notice No. CN103055137B(application number 201310021192.X) Chinese patent literature disclose a kind of Chinese medicine for the treatment of chronic pancreatitis, it is characterized in that, be prepared from by the medical material of following weight proportion: Rhizoma Chuanxiong 12 parts, Oletum Trogopterori 10 parts, Caulis Spatholobi 9 parts, Radix Achyranthis Bidentatae 12 parts, Fructus Leonuri 12 parts, 10 parts, golden waist, Radix Angelicae Sinensis 14 parts, Radix Polygoni Multiflori 14 parts, Bulbus Lilii 12 parts, Radix Asparagi 12 parts, Rhizoma Polygonati Odorati 10 parts.
In a word, Chinese medicine achieves good curative effect in treatment primary disease, but also there are some problems: clinical also not for the medicine of spleen invigorating warming middle-JIAO, activating qi for lowering adverse qi, consumer product dredge stasis, has much room for improvement to improving pancreatitis.
Summary of the invention
An object of the present invention overcomes the deficiencies in the prior art, provides a kind for the treatment of both the principal and secondary aspects of a disease, has no side effect, the pancreatitic compositions of improvement that is safe and effective, convenient drug administration.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
The pancreatitic compositions of a kind of improvement, comprise active constituents of medicine and substrate, wherein active constituents of medicine takes off the primary raw material stating weight proportion and is prepared from: Caulis Sargentodoxae 10-30 part, Fructus Crataegi 15-25 part, Radix Angelicae Sinensis 15-25 part, Radix Anemones Rivularis 5-15 part, black tea 8-16 part, Radix Aristolochiae 5-15 part, Rhizoma Corydalis 5-15 part, Flos Lonicerae 4-12 part, Fructus Musae 20-40 part, Concha Arcae 2-8 part, Semen Sesami Nigrum 10-15 part.
The pancreatitic compositions of a kind of improvement, preferred scheme, active constituents of medicine takes off the primary raw material stating weight proportion and is prepared from: Caulis Sargentodoxae 23-27 part, Fructus Crataegi 18-22 part, Radix Angelicae Sinensis 18-22 part, Radix Anemones Rivularis 8-13 part, black tea 10-14 part, Radix Aristolochiae 8-12 part, Rhizoma Corydalis 8-12 part, Flos Lonicerae 6-10 part, Fructus Musae 25-35 part, Concha Arcae 4-6 part, Semen Sesami Nigrum 11-14 part.
The pancreatitic compositions of a kind of improvement, the scheme be more preferably, active constituents of medicine takes off the primary raw material stating weight proportion and is prepared from: Caulis Sargentodoxae 25 parts, Fructus Crataegi 20 parts, Radix Angelicae Sinensis 20 parts, Radix Anemones Rivularis 10 parts, black tea 12 parts, Radix Aristolochiae 10 parts, Rhizoma Corydalis 10 parts, Flos Lonicerae 8 parts, 30 parts, Fructus Musae, Concha Arcae 5 parts, Semen Sesami Nigrum 12 parts.
The substrate of the pancreatitic compositions of above-mentioned improvement is glycerol, and wherein the proportioning of active constituents of medicine and substrate is 1:2.
The preparation method of the pancreatitic compositions of above-mentioned improvement, step is as follows:
1) Semen Sesami Nigrum is picked up decontamination, wash 2 times with water, dry, put in pan and fry 4-8 minute with little fire, the Semen Sesami Nigrum fried is placed in clean plate, dries in the air to room temperature, break into smalls stand-by;
2) by fresh Fructus Crataegi enucleation, one is divided into four, is placed in plate, mixes thoroughly with white sugar, steaming and decocting 40-50 minute, cools and mixes with Fructus Musae, be pounded thick liquid, thick liquid is placed in little fire on tile and dries 2-6 minute slowly, cool stand-by;
3) Caulis Sargentodoxae, Radix Angelicae Sinensis, Radix Anemones Rivularis, Radix Aristolochiae, Rhizoma Corydalis, Flos Lonicerae and Concha Arcae are together placed in the hot pot dryouied, with the little fire 4-8 minute that stir-fries repeatedly, spray into yellow wine, then the 5-10 minute that repeatedly stir-fries, dry in the air to crisp, grinding to form smalls, to cross 80-120 mesh sieve stand-by;
4) get a clean terrine, add mineral water, boil, put into black tea, soak after 20-40 minute and filter, obtain filtrate 1, will add the hot water of 80-100 DEG C in filtering residue, soaks 10 minutes, filtration, obtains filtrate 2, filtrate 1 is mixed with filtrate 2, obtain mixed liquor stand-by;
5) by step 1)-4) gains mixing, decoct and stir into thick paste, glycerol is placed in evaporating dish, heat fused in water-bath, add thick paste, stir, then whole material is poured in anus compositions mould, slightly to overflow mould for degree, finally scrape off spilling part, treat abundant cooled and solidified, carefully open model, take out compositions, pack with aluminium foil or polyethylene film and obtain compositions.
The preparation method of the pancreatitic compositions of above-mentioned improvement, step 1) is put in pan and is fried 7-9 minute (preferred, to put in pan and fry 6 minutes with little fire) with little fire.
The preparation method of the pancreatitic compositions of above-mentioned improvement, step 2) steaming and decocting 43-48 minute, cool and mix with Fructus Musae, be pounded thick liquid, thick liquid is placed in little fire on tile to dry 3-5 minute slowly (preferred, steaming and decocting 45 minutes, cools and mix with Fructus Musae, be pounded thick liquid, thick liquid be placed in little fire on tile and dry 4 minutes slowly).
The preparation method of the pancreatitic compositions of above-mentioned improvement, the step 3) little fire 5-7 minute that stir-fries repeatedly, sprays into yellow wine, more repeatedly stir-fry 6-9 minute (preferred, with little fire stir-frying 6 minutes repeatedly, to spray into yellow wine, more repeatedly stir-fry 8 minutes).
The preparation method of the pancreatitic compositions of above-mentioned improvement, step 3) grinds to form smalls and crosses 90-110 mesh sieve (preferred, to grind to form smalls and cross 100 mesh sieves).
The preparation method of the pancreatitic compositions of above-mentioned improvement, step 4) is soaked after 25-35 minute and is filtered, and obtains filtrate 1, will add the hot water (preferred, to soak after 30 minutes and filter, obtain filtrate 1, will add the hot water of 90 DEG C in filtering residue) of 85-95 DEG C in filtering residue.
The pharmacological effect of each crude drug is respectively:
Caulis Sargentodoxae: Caulis Sargentodoxae is the rattan of plants of Lardizabalaceae Caulis Sargentodoxae.Bitter in the mouth, property is put down.Return large intestine, Liver Channel.Tool removing toxicity for eliminating carbuncles, promoting blood circulation and stopping pain, expelling wind and removing dampness, disinsection efficiency.Cure mainly acute appendicitis, dysentery, mastalgia, dysmenorrhea, amenorrhea, traumatic injury, rheumatic arthralgia, abdominal pain due to worm stagnation.
Fructus Crataegi: stone fruit, caryoplasm is hard, and sarcocarp is thin, and taste is micro-sour and astringent.Fruit is raw-eaten or make preserved fruit fruitcake, can be used as medicine after drying, Chinese distinctive medicine fruit dual-purpose seeds, there is the effects such as blood fat reducing, blood pressure, heart tonifying, arrhythmia, also be simultaneously the good medicine of spleen benefiting and stimulating the appetite, relieving dyspepsia, phlegm reduction of blood circulation promoting, the disease such as, hernia, blood stasis full to chest and diaphragm spleen, amenorrhea has good curative effect.Flavone compound vitexin in Fructus Crataegi is the medicine that a kind of antitumaous effect is stronger, and its extract all has certain effect to growth of cancer cells, propagation and infiltration metastasis in suppression body.
Radix Angelicae Sinensis: enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.The all cards of main blood deficiency; Menoxenia; Amenorrhea; Dysmenorrhea; Lump in the abdomen knot is poly-; Metrorrhagia; Asthenia cold abdominalgia; Flaccidity syndrome and arthralgia syndrome; Numbness of the skin; Dryness of the intestine dyschezia; Heavy after bloody dysentery; Ulcer sores; Injury from falling down.
Radix Anemones Rivularis: heat-clearing and toxic substances removing, relaxing muscles and tendons to promote blood circulation.Control throat moth, mumps, scrofula tuberculosis, swollen ulcer drug, malaria, rheumatalgia, stomachache, traumatic injury.To pass through network, attack pyretic toxicity, except stomach expectorant.Stomach has expectorant poison, the many singultuss of people.Disappear red and swollen carbuncle furuncle cellulitis, blood wind mange, expectorant scrofula tuberculosis, tuberculosis of bone and joint bubo, outer tonsillitis, mumps, interior tonsillitis, has sore throat, root of the tooth pyretic toxicity.
Black tea: black tea can help gastro-intestinal digestion, promote appetite, can diuresis, eliminate edema, and strong cardiac function.In black tea, " flavone compound be rich in can eliminate free radical, has scavenging activity, reduces the sickness rate of myocardial infarction.The traditional Chinese medical science is thought, tea also divides cold and heat, and such as green tea belongs to bitter cold, and applicable summer drinks, for relieving summer heat; Black tea, Folium camelliae assamicae are partially warm, are comparatively applicable to drinking winter.Comparatively neutral as oolong tea, TIEGUANYIN etc.Under caffeine in black tea and aromatic substance synergy, increase the blood flow of kidney, improve glomerular filtration rate, nephrectasia blood capillary, and suppress renal tubules absorbing again water, so facilitate urine volume to increase.So be conducive to getting rid of the lactic acid in body, uric acid (with gout about), too much salinity (relevant with hypertension), nuisance etc., and relax the edema that heart disease or nephritis causes.Black tea not only can not injure one's stomach, on the contrary can nourishing the stomach.Often drink sugaring, black tea with milk, energy antiinflammatory, protection gastric mucosa, also have certain effect to treatment ulcer.
Radix Aristolochiae: pungent, bitter, cold.Gui Jing: return liver, stomach warp.Effect: suppressing the hyperactive liver pain relieving, removing toxic substances and promoting subsidence of swelling.Cure mainly: for dizziness and headache, chest and abdomen swelling and pain, carbuncle furuncle, snake bite and insect sting.
Rhizoma Corydalis: 1, nature and flavor: pungent; Bitter; Temperature; Nontoxic.2, Gui Jing: liver; Stomach; The heart; Lung; Spleen channel.3, cure mainly: invigorate blood circulation; Dissipating blood stasis; Regulate the flow of vital energy; Pain relieving.The all pains of main trusted subordinate's waist knee joint; Menoxenia; Lump in the abdomen; Metrorrhagia; Puerperal blood faints; Lochiorrhea; Traumatic injury.
Flos Lonicerae: modern study proves, Flos Lonicerae contains the pharmacological component such as chlorogenic acid, luteolin glycosides, stronger restraint is had to the various pathogens such as Hemolytic streptococcus, staphylococcus aureus and upper respiratory tract infection Causative virus etc., in addition also can enhancing immunity, antiearly pregnancy, hepatoprotective, antitumor, antiinflammatory, antipyretic, hemostasis (blood coagulation), suppress intestinal absorption cholesterol etc., its clinical application widely, can be used for the treatment of respiratory tract infection, bacillary dysentery, acute urinary, hypertension etc. more than 40 with other medicines compatibility and plant disease.
Fructus Musae: chemical composition fruit starch-containing 0.5%, protein 1.3%, fat 0.6%, sugar 11%, ash 1%, vitamin A, vitamin B, vitamin C, vitamin E etc.And containing a small amount of 5-hydroxy tryptamine, norepinephrine and dihydroxy benzenes ethamine.Leaf is containing a small amount of tannin and cellulose 11.55%.Function cures mainly: heat-clearing and toxic substances removing, and inducing diuresis to remove edema is antiabortive.Herb: for epidemic encephalitis type B, leucorrhea, frequent fetal movement; Carbuncle furuncle and phyma poison is controlled in external, erysipelas, otitis media.
Concha Arcae: there is expectorant blood stasis dispelling, hard masses softening and resolving, effect of relieving gastric hyperacidity to alleviate stomachache.Cementing for pertinacious phlegm, sticky difficulty is coughed up, goiter, scrofula, lump in the abdomen mass in the abdomen, stomachache pantothenic acid.
Semen Sesami Nigrum: Semen Sesami Nigrum medicine-food two-purpose, has health-care effecies such as " invigorating the liver and kidney, grow the five internal organs, benefiting essence-blood, intestine moistening is dry ", is regarded as nourishing holy product.Being because containing high quality protein and abundant mineral on the one hand, is because the sesamin containing abundant unsaturated fatty acid, vitamin E and preciousness and melanin on the other hand.Semen Sesami Nigrum medicine-food two-purpose, has effects such as " invigorating the liver and kidney, grow the five internal organs, benefiting essence-blood, intestine moistening is dry ", is regarded as nourishing holy product.Semen Sesami Nigrum has health-care effect.
With prior art ratio, beneficial effect of the present invention is:
The present invention improves pancreatitic compositions debates disease control principle based on Chinese medicine, scientific formulation, treating both the principal and secondary aspects of a disease, have no side effect, safe and effective, convenient drug administration, avoid and use Chinese medicine and Western medicine dysphagia, the ill-matched defect of child, effectively can improve pancreatitis.
detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1the pancreatitic compositions of a kind of improvement, comprise active constituents of medicine and substrate, wherein active constituents of medicine takes off the primary raw material stating weight proportion and is prepared from: Caulis Sargentodoxae 10 parts, Fructus Crataegi 15 parts, Radix Angelicae Sinensis 15 parts, Radix Anemones Rivularis 5 parts, black tea 8 parts, Radix Aristolochiae 5 parts, Rhizoma Corydalis 5 parts, Flos Lonicerae 4 parts, 20 parts, Fructus Musae, Concha Arcae 2 parts, Semen Sesami Nigrum 10 parts.
The substrate of the pancreatitic compositions of above-mentioned improvement is glycerol, and wherein the proportioning of active constituents of medicine and glycerol is 1:2.
The preparation method of the pancreatitic compositions of above-mentioned improvement, step is as follows:
1) Semen Sesami Nigrum is picked up decontamination, wash 2 times with water, dry, put in pan and fry 4 minutes with little fire, the Semen Sesami Nigrum fried is placed in clean plate, dries in the air to room temperature, break into smalls stand-by;
2) by fresh Fructus Crataegi enucleation, one is divided into four, is placed in plate, mixes thoroughly with white sugar, steaming and decocting 40 minutes, cools and mixes with Fructus Musae, be pounded thick liquid, thick liquid is placed in little fire on tile and dries 2 minutes slowly, cool stand-by;
3) Caulis Sargentodoxae, Radix Angelicae Sinensis, Radix Anemones Rivularis, Radix Aristolochiae, Rhizoma Corydalis, Flos Lonicerae and Concha Arcae are together placed in the hot pot dryouied, with little fire stir-frying 4 minutes repeatedly, spray into yellow wine, more repeatedly stir-fry 5 minutes, dry in the air to crisp, grinding to form smalls, to cross 80 mesh sieves stand-by;
4) get a clean terrine, add mineral water, boil, put into black tea, soak after 20 minutes and filter, obtain filtrate 1, will add the hot water of 80 DEG C in filtering residue, soaks 10 minutes, filtration, obtains filtrate 2, filtrate 1 is mixed with filtrate 2, obtain mixed liquor stand-by;
5) by step 1)-4) gains mixing, decoct and stir into thick paste, glycerol is placed in evaporating dish, heat fused in water-bath, add thick paste, stir, then whole material is poured in anus compositions mould, slightly to overflow mould for degree, finally scrape off spilling part, treat abundant cooled and solidified, carefully open model, take out compositions, pack with aluminium foil or polyethylene film and obtain compositions.
model case one:king XX, man, 45 years old, people from Jinan, before 2 months, there is the abdominal distention of unknown cause in certain high school teachers, the symptoms such as stomachache, originally think and oneself have eaten thing bad, bought JIANWEI XIAOSHI PIAN use voluntarily, effective when using at the beginning, serious all the more after drug withdrawal, have also appeared not eating, distension after food, constipation after 2 days, constipation is very serious, vomiting, stomach have the malaise symptoms of burning sensation, and patient does not like Western medicine, and doctor advised uses resulting composition of the present invention.
Give to use the embodiment of the present invention 1 to obtain compositions, after 2 days, the symptom of patient's self-induction abdominal distention, stomachache alleviates to some extent, and defecation is smooth and easy, and continue to use 5 days, malaise symptoms disappears substantially, and defecation is always very normal.
embodiment 2the pancreatitic compositions of a kind of improvement, comprise active constituents of medicine and substrate, wherein active constituents of medicine takes off the primary raw material stating weight proportion and is prepared from: Caulis Sargentodoxae 30 parts, Fructus Crataegi 25 parts, Radix Angelicae Sinensis 25 parts, Radix Anemones Rivularis 15 parts, black tea 16 parts, Radix Aristolochiae 15 parts, Rhizoma Corydalis 15 parts, Flos Lonicerae 12 parts, 40 parts, Fructus Musae, Concha Arcae 8 parts, Semen Sesami Nigrum 15 parts.
The substrate of the pancreatitic compositions of above-mentioned improvement is glycerol, and wherein the proportioning of active constituents of medicine and glycerol is 1:2.
The preparation method of the pancreatitic compositions of above-mentioned improvement, step is as follows:
1) Semen Sesami Nigrum is picked up decontamination, wash 2 times with water, dry, put in pan and fry 8 minutes with little fire, the Semen Sesami Nigrum fried is placed in clean plate, dries in the air to room temperature, break into smalls stand-by;
2) by fresh Fructus Crataegi enucleation, one is divided into four, is placed in plate, mixes thoroughly with white sugar, steaming and decocting 50 minutes, cools and mixes with Fructus Musae, be pounded thick liquid, thick liquid is placed in little fire on tile and dries 6 minutes slowly, cool stand-by;
3) Caulis Sargentodoxae, Radix Angelicae Sinensis, Radix Anemones Rivularis, Radix Aristolochiae, Rhizoma Corydalis, Flos Lonicerae and Concha Arcae are together placed in the hot pot dryouied, with little fire stir-frying 8 minutes repeatedly, spray into yellow wine, more repeatedly stir-fry 10 minutes, dry in the air to crisp, grinding to form smalls, to cross 120 mesh sieves stand-by;
4) get a clean terrine, add mineral water, boil, put into black tea, soak after 40 minutes and filter, obtain filtrate 1, will add the hot water of 100 DEG C in filtering residue, soaks 10 minutes, filtration, obtains filtrate 2, filtrate 1 is mixed with filtrate 2, obtain mixed liquor stand-by;
5) by step 1)-4) gains mixing, decoct and stir into thick paste, glycerol is placed in evaporating dish, heat fused in water-bath, add thick paste, stir, then whole material is poured in anus compositions mould, slightly to overflow mould for degree, finally scrape off spilling part, treat abundant cooled and solidified, carefully open model, take out compositions, pack with aluminium foil or polyethylene film and obtain compositions.
embodiment 3the pancreatitic compositions of a kind of improvement, comprise active constituents of medicine and substrate, wherein active constituents of medicine takes off the primary raw material stating weight proportion and is prepared from: Caulis Sargentodoxae 23 parts, Fructus Crataegi 18 parts, Radix Angelicae Sinensis 18 parts, Radix Anemones Rivularis 8 parts, black tea 10 parts, Radix Aristolochiae 8 parts, Rhizoma Corydalis 8 parts, Flos Lonicerae 6 parts, 25 parts, Fructus Musae, Concha Arcae 4 parts, Semen Sesami Nigrum 11 parts.
The substrate of the pancreatitic compositions of above-mentioned improvement is glycerol, and wherein the proportioning of active constituents of medicine and glycerol is 1:2.
The preparation method of the pancreatitic compositions of above-mentioned improvement, step is as follows:
1) Semen Sesami Nigrum is picked up decontamination, wash 2 times with water, dry, put in pan and fry 5 minutes with little fire, the Semen Sesami Nigrum fried is placed in clean plate, dries in the air to room temperature, break into smalls stand-by;
2) by fresh Fructus Crataegi enucleation, one is divided into four, is placed in plate, mixes thoroughly with white sugar, steaming and decocting 43 minutes, cools and mixes with Fructus Musae, be pounded thick liquid, thick liquid is placed in little fire on tile and dries 3 minutes slowly, cool stand-by;
3) Caulis Sargentodoxae, Radix Angelicae Sinensis, Radix Anemones Rivularis, Radix Aristolochiae, Rhizoma Corydalis, Flos Lonicerae and Concha Arcae are together placed in the hot pot dryouied, with little fire stir-frying 5 minutes repeatedly, spray into yellow wine, more repeatedly stir-fry 6 minutes, dry in the air to crisp, grinding to form smalls, to cross 90 mesh sieves stand-by;
4) get a clean terrine, add mineral water, boil, put into black tea, soak after 25 minutes and filter, obtain filtrate 1, will add the hot water of 85 DEG C in filtering residue, soaks 10 minutes, filtration, obtains filtrate 2, filtrate 1 is mixed with filtrate 2, obtain mixed liquor stand-by;
5) by step 1)-4) gains mixing, decoct and stir into thick paste, glycerol is placed in evaporating dish, heat fused in water-bath, add thick paste, stir, then whole material is poured in anus compositions mould, slightly to overflow mould for degree, finally scrape off spilling part, treat abundant cooled and solidified, carefully open model, take out compositions, pack with aluminium foil or polyethylene film and obtain compositions.
model case two:woods XX, female, 35 years old, people from Jinan, because of paroxysmal abdominal pain abdominal distention before 3 months, non-defecation aerofluxus is admitted to hospital for 3 days, and when doctor makes the rounds of the wards, patient's readme is stomach distending pain after meal, retch, uncomfortable in chest, have heartburn, acid regurgitation sense, constipation, doctor advised use the present composition.
Use the embodiment of the present invention 3 resulting composition 2 days, after conscious medicine, abdominal distention, gastral cavilty distension slightly alleviate, and do not occur heartburn, acid regurgitation, arteries and veins slight force, and relieving constipation is smooth and easy; Continue and take 3 days, abdominal distention, gastral cavilty distension are not obvious; Diet increases, comfortable in stomach after food; Stool is once a day, not dry not rare; Without singultus, heartburn, acid regurgitation symptom.
embodiment 4the pancreatitic compositions of a kind of improvement, comprise active constituents of medicine and substrate, wherein active constituents of medicine takes off the primary raw material stating weight proportion and is prepared from: Caulis Sargentodoxae 27 parts, Fructus Crataegi 22 parts, Radix Angelicae Sinensis 22 parts, Radix Anemones Rivularis 13 parts, black tea 14 parts, Radix Aristolochiae 12 parts, Rhizoma Corydalis 12 parts, Flos Lonicerae 10 parts, 35 parts, Fructus Musae, Concha Arcae 6 parts, Semen Sesami Nigrum 14 parts.
The substrate of the pancreatitic compositions of above-mentioned improvement is glycerol, and wherein the proportioning of active constituents of medicine and glycerol is 1:2.
The preparation method of the pancreatitic compositions of above-mentioned improvement, step is as follows:
1) Semen Sesami Nigrum is picked up decontamination, wash 2 times with water, dry, put in pan and fry 7 minutes with little fire, the Semen Sesami Nigrum fried is placed in clean plate, dries in the air to room temperature, break into smalls stand-by;
2) by fresh Fructus Crataegi enucleation, one is divided into four, is placed in plate, mixes thoroughly with white sugar, steaming and decocting 48 minutes, cools and mixes with Fructus Musae, be pounded thick liquid, thick liquid is placed in little fire on tile and dries 5 minutes slowly, cool stand-by;
3) Caulis Sargentodoxae, Radix Angelicae Sinensis, Radix Anemones Rivularis, Radix Aristolochiae, Rhizoma Corydalis, Flos Lonicerae and Concha Arcae are together placed in the hot pot dryouied, with little fire stir-frying 7 minutes repeatedly, spray into yellow wine, more repeatedly stir-fry 9 minutes, dry in the air to crisp, grinding to form smalls, to cross 80-120 mesh sieve stand-by;
4) get a clean terrine, add mineral water, boil, put into black tea, soak after 35 minutes and filter, obtain filtrate 1, will add the hot water of 95 DEG C in filtering residue, soaks 10 minutes, filtration, obtains filtrate 2, filtrate 1 is mixed with filtrate 2, obtain mixed liquor stand-by;
5) by step 1)-4) gains mixing, decoct and stir into thick paste, glycerol is placed in evaporating dish, heat fused in water-bath, add thick paste, stir, then whole material is poured in anus compositions mould, slightly to overflow mould for degree, finally scrape off spilling part, treat abundant cooled and solidified, carefully open model, take out compositions, pack with aluminium foil or polyethylene film and obtain compositions.
embodiment 5the pancreatitic compositions of a kind of improvement, comprise active constituents of medicine and substrate, wherein active constituents of medicine takes off the primary raw material stating weight proportion and is prepared from: Caulis Sargentodoxae 25 parts, Fructus Crataegi 20 parts, Radix Angelicae Sinensis 20 parts, Radix Anemones Rivularis 10 parts, black tea 12 parts, Radix Aristolochiae 10 parts, Rhizoma Corydalis 10 parts, Flos Lonicerae 8 parts, 30 parts, Fructus Musae, Concha Arcae 5 parts, Semen Sesami Nigrum 12 parts.
The substrate of the pancreatitic compositions of above-mentioned improvement is glycerol, and wherein the proportioning of active constituents of medicine and glycerol is 1:2.
The preparation method of the pancreatitic compositions of above-mentioned improvement, step is as follows:
1) Semen Sesami Nigrum is picked up decontamination, wash 2 times with water, dry, put in pan and fry 6 minutes with little fire, the Semen Sesami Nigrum fried is placed in clean plate, dries in the air to room temperature, break into smalls stand-by;
2) by fresh Fructus Crataegi enucleation, one is divided into four, is placed in plate, mixes thoroughly with white sugar, steaming and decocting 45 minutes, cools and mixes with Fructus Musae, be pounded thick liquid, thick liquid is placed in little fire on tile and dries 4 minutes slowly, cool stand-by;
3) Caulis Sargentodoxae, Radix Angelicae Sinensis, Radix Anemones Rivularis, Radix Aristolochiae, Rhizoma Corydalis, Flos Lonicerae and Concha Arcae are together placed in the hot pot dryouied, with little fire stir-frying 6 minutes repeatedly, spray into yellow wine, more repeatedly stir-fry 8 minutes, dry in the air to crisp, grinding to form smalls, to cross 100 mesh sieves stand-by;
4) get a clean terrine, add mineral water, boil, put into black tea, soak after 30 minutes and filter, obtain filtrate 1, will add the hot water of 90 DEG C in filtering residue, soaks 10 minutes, filtration, obtains filtrate 2, filtrate 1 is mixed with filtrate 2, obtain mixed liquor stand-by;
5) by step 1)-4) gains mixing, decoct and stir into thick paste, glycerol is placed in evaporating dish, heat fused in water-bath, add thick paste, stir, then whole material is poured in anus compositions mould, slightly to overflow mould for degree, finally scrape off spilling part, treat abundant cooled and solidified, carefully open model, take out compositions, pack with aluminium foil or polyethylene film and obtain compositions.
experimental example:1, selection of clinical: in order to verify that the present invention improves the effect of pancreatitic compositions, the patient that we have extracted 400 20-60 years has carried out the experiment of medicine, be equally divided into two groups, experimental group and matched group, two groups in age, sex, clinical manifestation etc. through statistical analysis there was no significant difference.
2, inclusion criteria: through making a definite diagnosis the constipation suffered from because dyspepsia causes, showing as abdominal distention, suffering from abdominal pain, eat up thing after acid regurgitation, the symptoms such as vomiting, heating.
3, Therapeutic Method: treatment group: adopt the present invention to improve pancreatitic compositions, peel off the aluminium foil or polyethylene film wrapped up in outside compositions, dip in a little vegetable oil or vaseline on compositions top, compositions is slowly pushed 2 ~ 3 centimetres, anus; Every day is each one piece of compositions sooner or later, twice on the one.
Matched group: the pancreatitic medicine of other treatment.
4, curative effect situation criterion: cure: after using the present invention, malaise symptoms disappears, effectively: after using the present invention, malaise symptoms alleviates, invalid: after using the present invention, malaise symptoms is unchanged.
Accurately the data of two groups of experiments are added up and mathematical analysis, obtain specific experiment result as following table:
Table 1:
Prove through clinical trial, it is 98% that the present invention improves pancreatitic effective percentage, the present invention is by Caulis Sargentodoxae, Fructus Crataegi, Radix Angelicae Sinensis, Radix Anemones Rivularis, black tea, Radix Aristolochiae, Rhizoma Corydalis, Flos Lonicerae, Fructus Musae, Concha Arcae and Semen Sesami Nigrum have loosening bowel to relieve constipation, the Chinese medicine composition of aid digestion and pleasant stomach invigorating together, treatment pancreatitis can be played, adopting the present invention to improve pancreatitic compositions treats compared with pancreatitic effect with use, instant effect, have no side effect, drug safety, convenient drug administration, avoid the dysphagia using other oral drugs, the ill-matched defect of child, effectively can improve pancreatitis.
Claims (10)
1. one kind is improved pancreatitic compositions, it is characterized in that: comprise active constituents of medicine and substrate, wherein active constituents of medicine takes off the primary raw material stating weight proportion and is prepared from: Caulis Sargentodoxae 10-30 part, Fructus Crataegi 15-25 part, Radix Angelicae Sinensis 15-25 part, Radix Anemones Rivularis 5-15 part, black tea 8-16 part, Radix Aristolochiae 5-15 part, Rhizoma Corydalis 5-15 part, Flos Lonicerae 4-12 part, Fructus Musae 20-40 part, Concha Arcae 2-8 part, Semen Sesami Nigrum 10-15 part.
2. the pancreatitic compositions of improvement according to claim 1, is characterized in that: active constituents of medicine takes off the primary raw material stating weight proportion and is prepared from: Caulis Sargentodoxae 23-27 part, Fructus Crataegi 18-22 part, Radix Angelicae Sinensis 18-22 part, Radix Anemones Rivularis 8-13 part, black tea 10-14 part, Radix Aristolochiae 8-12 part, Rhizoma Corydalis 8-12 part, Flos Lonicerae 6-10 part, Fructus Musae 25-35 part, Concha Arcae 4-6 part, Semen Sesami Nigrum 11-14 part.
3. the pancreatitic compositions of improvement according to claim 1, is characterized in that: active constituents of medicine takes off the primary raw material stating weight proportion and is prepared from: Caulis Sargentodoxae 25 parts, Fructus Crataegi 20 parts, Radix Angelicae Sinensis 20 parts, Radix Anemones Rivularis 10 parts, black tea 12 parts, Radix Aristolochiae 10 parts, Rhizoma Corydalis 10 parts, Flos Lonicerae 8 parts, 30 parts, Fructus Musae, Concha Arcae 5 parts, Semen Sesami Nigrum 12 parts.
4. the substrate of the pancreatitic compositions of the improvement according to any one of claim 1-3 is glycerol, it is characterized in that: wherein the proportioning of active constituents of medicine and substrate is 1:2.
5. the preparation method of the pancreatitic compositions of the improvement according to any one of claim 1-4, is characterized in that: step is as follows:
1) Semen Sesami Nigrum is picked up decontamination, wash 2 times with water, dry, put in pan and fry 4-8 minute with little fire, the Semen Sesami Nigrum fried is placed in clean plate, dries in the air to room temperature, break into smalls stand-by;
2) by fresh Fructus Crataegi enucleation, one is divided into four, is placed in plate, mixes thoroughly with white sugar, steaming and decocting 40-50 minute, cools and mixes with Fructus Musae, be pounded thick liquid, thick liquid is placed in little fire on tile and dries 2-6 minute slowly, cool stand-by;
3) Caulis Sargentodoxae, Radix Angelicae Sinensis, Radix Anemones Rivularis, Radix Aristolochiae, Rhizoma Corydalis, Flos Lonicerae and Concha Arcae are together placed in the hot pot dryouied, with the little fire 4-8 minute that stir-fries repeatedly, spray into yellow wine, then the 5-10 minute that repeatedly stir-fries, dry in the air to crisp, grinding to form smalls, to cross 80-120 mesh sieve stand-by;
4) get a clean terrine, add mineral water, boil, put into black tea, soak after 20-40 minute and filter, obtain filtrate 1, will add the hot water of 80-100 DEG C in filtering residue, soaks 10 minutes, filtration, obtains filtrate 2, filtrate 1 is mixed with filtrate 2, obtain mixed liquor stand-by;
5) by step 1)-4) gains mixing, decoct and stir into thick paste, glycerol is placed in evaporating dish, heat fused in water-bath, add thick paste, stir, then whole material is poured in anus compositions mould, slightly to overflow mould for degree, finally scrape off spilling part, treat abundant cooled and solidified, carefully open model, take out compositions, pack with aluminium foil or polyethylene film and obtain compositions.
6. the preparation method of the pancreatitic compositions of improvement according to claim 5, is characterized in that: step 1) is put in pan and fried 7-9 minute (preferred, to put in pan and fry 6 minutes with little fire) with little fire.
7. the preparation method of the pancreatitic compositions of improvement according to claim 5, it is characterized in that: step 2) steaming and decocting 43-48 minute, cool and mix with Fructus Musae, be pounded thick liquid, thick liquid is placed in little fire on tile to dry 3-5 minute slowly (preferred, steaming and decocting 45 minutes, cools and mix with Fructus Musae, be pounded thick liquid, thick liquid be placed in little fire on tile and dry 4 minutes slowly).
8. the preparation method of the pancreatitic compositions of improvement according to claim 5, is characterized in that: the little fire of the step 3) 5-7 minute that stir-fries repeatedly, sprays into yellow wine, repeatedly stir-fry 6-9 minute again (preferably, with little fire stir-frying 6 minutes repeatedly, spray into yellow wine, more repeatedly stir-fry 8 minutes).
9. the preparation method of the pancreatitic compositions of improvement according to claim 5, is characterized in that: step 3) grinds to form smalls and crosses 90-110 mesh sieve (preferred, to grind to form smalls and cross 100 mesh sieves).
10. the preparation method of the pancreatitic compositions of improvement according to claim 5, it is characterized in that: step 4) is soaked after 25-35 minute and filtered, obtain filtrate 1, by (preferred for the hot water adding 85-95 DEG C in filtering residue, soak after 30 minutes and filter, obtain filtrate 1, the hot water of 90 DEG C will be added in filtering residue).
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101129556A (en) * | 2007-08-09 | 2008-02-27 | 倪慧文 | Orally taken traditional Chinese medicine for treating acute pancreatitis |
| CN102940866A (en) * | 2012-12-02 | 2013-02-27 | 吕建晓 | Traditional Chinese medicine composition for treating idiopathic chronic pancreatitis and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101129556A (en) * | 2007-08-09 | 2008-02-27 | 倪慧文 | Orally taken traditional Chinese medicine for treating acute pancreatitis |
| CN102940866A (en) * | 2012-12-02 | 2013-02-27 | 吕建晓 | Traditional Chinese medicine composition for treating idiopathic chronic pancreatitis and preparation method thereof |
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Application publication date: 20151223 |