CN105168077A - Skin care composition, applications, preparation method and products - Google Patents
Skin care composition, applications, preparation method and products Download PDFInfo
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- CN105168077A CN105168077A CN201510500680.8A CN201510500680A CN105168077A CN 105168077 A CN105168077 A CN 105168077A CN 201510500680 A CN201510500680 A CN 201510500680A CN 105168077 A CN105168077 A CN 105168077A
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Abstract
The invention relates to the cosmetic technology field, and especially relates to a skin care composition, applications, a preparation method and products. The composition comprises cotton flower bud and cotton nectar extract products, corn gluten meal enzymolysis extracts product and flaxseed extract products. The composition can increase skin stratum corneum thickness obviously and can increase skin moisture obviously, compatibility is reasonable, and the composition is safe to use and has no stimulation. A single extract product has few components, the effects of the composition are substantial, the components are combined, and the synergism effect is obvious. The composition can promote multiplication of skin resident beneficial bacteria obviously, has inhibition effects on skin transient harmful bacteria and conditioned pathogens, therefore beneficial bacteria dominate and skin microecological balance is promoted.
Description
Technical field
The present invention relates to cosmetic technical field, particularly a kind of skin care compositions and methods and application thereof, preparation method, product.
Background technology
Skin covering, in human body surface, directly contacts with external environment, for protecting the natural cover of human body.The complex structure of skin high special; can prevent extraneous chemical factors from stimulating damage in-vivo tissue; and the absorption blending material to external world outside body fluid can be stoped; simultaneously external microbe can also be stopped: as the invasion of antibacterial, fungus, virus, parasite and other pathogen, have important barrier action and protective effect.The skin accessory organs such as skin is by epidermal area, skin corium, subcutaneus adipose tissue layer, and sweat gland, hair follicle are formed.Epidermal area can be subdivided into horny layer, granular layer, spinous layer, and basal layer.Its mesocuticle plays an important role in maintenance skin barrier function.
A research according to the U.S. shows, the skin surface of human body grows about 250 kinds of antibacterials, and only human body forearm just grows 182 kinds of antibacterials, be divided into 91 classes, wherein the antibacterial of 8% is not formally recorded by scientist.Under normal operation, body surface and the tract communicated with the external world exist to the harmless various antibacterial of health, be called normal flora or normal bacteria.After normal person's birth soon, skin is namely with antibacterial, and wherein a part of flora can for a long time in skin growth breeding, and we are referred to as the permanent bacterium of skin, if staphylococcus epidermidis, seat skin ulcer propionibacterium etc. are the main permanent dominant bacterias of skin; Some flora be temporary transient land on skin, after the regular period, can disappear from skin, we are referred to as skin and stay temporarily bacterium, comprise staphylococcus aureus, gram negative bacteria and some produce pigment micrococcus luteus etc.Skin flora wherein great majority is all useful to our body, as cleared up the rubbish (cell of apoptosis) of skin surface, decomposes unnecessary lipid, produces antibacterial peptide, resists external pathogen invasion etc. by competitive inhibition.Skin Tiny ecosystem flora has for skin provides nutrition, participates in skin cell metabolism nourishes rough skin, participates in immunity of organism effect, suppresses harmful bacteria clean skin, forms biological shield and forms biological barrier effect.The anti-mattress peptide (AMPs) that skin resides bacterium generation is the micromolecule polypeptide that a class has the anti-mattress activity of wide spectrum, and it is healthy that it participates in skin physiology by direct antibacterial effects and activate immunity reaction etc.。
The growth of beneficial flora has multiple action to human body skin, first, probiotic bacteria can participate in the metabolism of skin sebum gland, form one deck emulsified fatty substance film, this layer of lipid film is made up of free fatty, it can neutralize the alkaline matter be infected with on skin, suppresses the stay temporarily field planting of the pathogenic microorganism such as bacterium, fungus, Growth and reproduction, plays an important role to skin self-cleaning.Secondly; have levels and the beneficial flora of field planting on skin in an orderly manner; especially as one deck biomembrane; not only exposed to body epidermis plays occupy-place protective effect; and rely on each other with other floras, mutually restrict; form a stable mutually harmonious biological barrier mutually, improve skin immune function controlling, the health of protection body.3rd, the growth of probiotics of skin surface can decompose compositions such as producing phospholipid, steroid, keratoprotein, can be absorbed, promote dermal cell growth by Skin Cell, and delaying aging and minimizing wrinkle produce.In a normal equilibrium state, probiotic bacteria is after the specific part growth of skin surface, connect to capture position by tight and epithelial cell, due to very large in these position quantity, have the advantage in nutrient competition, and pH value or the release antibiotic of environment is changed by own metabolism, suppress the growth of foreign bacteria, other flora is had to the effect of biological antagonist.If the balance of some factors disrupt between probiotic bacteria and pernicious bacteria, as skin environment slight change, use antibiotic, the factor such as use of disinfectant and potent cleaning agent all can constitute a threat to probiotic bacteria.When the quantity of probiotic bacteria and other antibacterials and ratio change, be called dysbacteriosis.Now, probiotic bacteria reduces, and harmful bacteria just can be taken advantage of the occasion to breed and be replaced the position of probiotic bacteria, and can control and cutaneous environment, the pH value of skin is increased, and this pH value environment is unfavorable for the growth of probiotic bacteria, therefore the quantity of probiotic bacteria will reduce further, and the first barrier of skin is destroyed.If dysbacteriosis is not effectively controlled, skin just there will be the clinical symptoms such as redness, inflammation, causes superinfection, causes skin damage and aging.Therefore, skin probiotic bacteria is protected to be very important for the integrity maintaining skin texture and function.
The most effective method of protection skin probiotic bacteria is the beneficial flora by providing the nutrition of probiotic bacteria usually to strengthen skin surface; namely by being probiotic bacteria supplement and nutrition; impel growth of probiotics and keep balance; strengthening beneficial flora; even if the natural balance of skin is destroyed; this kind of nutrient also can help probiotic bacteria to recover rapidly; make probiotic bacteria relative to harmful bacteria advantageously; contention nutrition; thus indirectly suppress harmful bacteria; form skin care barrier, stop the intrusion of harmful bacteria, thus to pathogenic bacterium determine grow generation antagonism.
At present, the conventional skin care item of commercial type are the composition such as a large amount of use synthetic surfactant, antiseptic generally, while killing skin harmful bacteria, also damages skin beneficiating bacterium in a large number, destroys skin microbial ecological, lead chapped skin, inflammation, the symptoms such as pruritus.Therefore gentleness, safe skin nursing product is developed highly significant.
Patent publication No. is that the patent of invention of CN102459310A discloses a kind of cosmetic composition/or the pharmaceutical composition that comprise the peptide hydrolysis products that can strengthen barrier function, and the peptide hydrolysis products being rich in biologically active peptide can strengthen skin barrier function and stimulate epidermal differentiation.But the preparation method of the bioactive peptide wherein provided is loaded down with trivial details, bioactive peptide is only 4 ~ 6 amino acid whose little peptides, and Structure composing is special, can not meet actual needs.
Number of patent application be 201010547965.4 patent of invention disclose a kind of cleansing cream containing Semen Lini oil and preparation method thereof, it uses cold rolling Semen Lini oil to prepare cleansing cream as raw material.This type of patent only uses Semen Lini oil, and does not make full use of the flax glue of rich content in Semen Lini, and lignan isoreactivity composition.
And the care product of above-mentioned patented product and commercial type does not also reach desirable level for the nursing role of scalp or skin.Therefore, provide a kind of pure natural, can the skin care item of effective nursing skin have important practical significance.
Summary of the invention
In view of this, the invention provides a kind of skin care compositions and methods and application thereof, preparation method, product.Said composition obviously can increase stratum corneum thickness, and obviously increases moisture of skin, and compatibility is reasonable, and use safety is non-stimulated; When the dosage of the present composition is few compared to single extract component, effect is more remarkable on the contrary, and each component in conjunction uses can produce obvious synergistic function; The present composition obviously can promote that skin resides the increment of probiotics, and temporarily harmful bacteria is stayed to skin and conditioned pathogen inhibited, thus probiotic bacteria is had the advantage status, promotes skin microecological balance.
In order to realize foregoing invention object, the invention provides following technical scheme:
The invention provides a kind of compositions, comprise Cotton Gossypii alabastrum and Cotton Gossypii nectar extract, Zein powder enzymatic hydrolyzed extract and extractive of flax seed.
Cotton Gossypii alabastrum is the natural shedding of Cotton Gossypii bud stage or artificial comb flower alabastrum, particularly huge in Cotton Gossypii main producing region output.Cotton Gossypii alabastrum composition Study is shown that it contains abundant total flavones, is mainly hyperin and isoquercitin.Mel is the nectar of Apis herborization, secretions or honeydew, after being combined with self secretions, and the natural sweet taste material through fully brewageing.Cotton Gossypii is also a kind of nectar source preferably, and contained complex chemical composition in Cotton Gossypii Mel, is also constantly going deep into its research.Flavonoid wherein, phenolic acids, carbohydrate content content are higher, in addition also containing protein, organic acid, aminoacid, enzyme, volatile ingredient, trace element etc.Cotton Gossypii Fructose in Honey and glucose content >=60%, cane sugar content is lower than 5%.Derive from the main flavor composition that glucose in nectar and fructose are Mel, the ratio of the two mostly close to 1:1, and is one of reason of honey crystallization, the higher then easier crystallization of glucose content wherein.Disaccharidase in Cotton Gossypii Mel also has maltose, 2-O-alpha-D-Glucopyranosyl-D-glucose., dextrinose, trehalose, turanose, 3-O-beta-D-Glucopyranosyl-D-glucose, nigerose, gentiobiose etc.In addition, a small amount of oligosaccharide is also had, as melezitose, maltotriose, GF2, cotton seed trisaccharide, fructose maltose, Isomaltotetraose, different maltopentaose etc.The Cotton Gossypii alabastrum that the present invention uses and the composite extract that Cotton Gossypii nectar extract obtains for Cotton Gossypii alabastrum extract and the mixing of Cotton Gossypii nectar.This composite extract is rich in monosaccharide, oligosaccharide and Cotton Gossypii total flavones.
Semen Maydis is one of Three major grain crops in the world, and Ye Shi China conventional crop, output is 1.2 hundred million tons, occupies second place of the world.The nutritional labeling of Semen Maydis is relatively more comprehensive, and generally starch-containing about 80%, protein 10% (being mainly alcohol soluble protein), fat 4%, and a small amount of vitamin, aminoacid etc.Zein powder by-product after corn processed starch, is commonly called as Semen Maydis grit or maize yellow-powder, containing zein, and the composition such as corn starch, in China as cheap feedstuff or naturally discharge, causes very large waste and environmental pollution.In Zein powder, protein content is up to more than 60%, compared with other raw materials, and the uniqueness that zein forms because of its aminoacid and there is special physiologically active.The present invention uses zymolysis technique according to the aminoacid sequence feature of zein, obtains the low peptide combinations that 2-6 aminoacid forms targetedly, and this serial low peptide has better physiologically active.The Semen Maydis enzymatic hydrolyzed extract that the present invention uses, except being rich in Semen Maydis polypeptide, is also rich in oligosaccharide, and containing appropriate saponin and nucleic acid composition, can as good cosmetic material.
Semen Lini (flaxseed or linseed), also known as flaxseed, is the seed of the annual of flax family (Linaceae) linum or herbaceos perennial Caulis et Folium Lini, originates from Mediterranean.In China, Caulis et Folium Lini is mainly distributed in the ground such as North China, northwest, and be one of large oil crop of China five, Semen Lini output about 500,000 tons, area and total output are only second to Canada, occupy second place of the world.The commodity value past major embodiment of Semen Lini is oily use, and its potential value is far from being exploited.Containing a large amount of material such as alpha-linolenic acid, linoleic acid, flax glue, lignan useful to human body in Semen Lini.Oil-containing more than 35% in Semen Lini, wherein about 50% is alpha-linolenic acid.Flax glue is a kind of new type natural plant colloid extracted from Semen Lini, flax glue is also known as Flax Seed Gum (Flaxseedgum), be present in flax seed husk, content is 10% ~ 15%, the polysaccharose substance of its main component 80% and the protein of 9%, Semen Lini glue has the emulsifying and Stabilization that have very much.Lignan is distributed widely among plant kingdom and multiple food, and especially among the corn and beans of granulate, the content in Semen Lini is the highest (1.0% ~ 4.0%), and its content exceeds 75 ~ 800 times than other food.Lignan main in Semen Lini is secoisolarciresinol (SECO) and its glucosides open loop secoisolariciresinoldiglucoside diglucoside (SDG).Semen Lini lignan has well antibacterial and antioxidation, senile-resistant efficacy.Industrial Semen Lini generally produces Semen Lini oil, extracts the residue after Semen Lini oil generally as feedstuff or Fertilizer application.Extractive of flax seed of the present invention expects slag after making full use of Semen Lini oil refining, adopt alcohol extracting method, the multiple efficacies compositions such as linolenic acid, lignan, Semen Lini cyclic peptide and flax glue in abundant extraction Semen Lini material slag, extractive of flax seed prepared by the inventive method possesses good antibacterial, the multi-efficiency such as emulsifying and antioxidation.
Simultaneously, the present invention's research shows, by Cotton Gossypii alabastrum and Cotton Gossypii nectar extract, Zein powder enzymatic hydrolyzed extract and extractive of flax seed conbined usage compared to being used alone, obviously can increase stratum corneum thickness, and obviously increase moisture of skin, compatibility is reasonable, and use safety is non-stimulated.When the dosage of the present composition is few compared to single extract component, effect is more remarkable on the contrary, and therefore in the present invention, each component in conjunction uses and can produce obvious synergistic function.
As preferably, the mass ratio of Cotton Gossypii alabastrum and Cotton Gossypii nectar extract, Zein powder enzymatic hydrolyzed extract and extractive of flax seed is (5 ~ 20): (5 ~ 20): (5 ~ 20).
In embodiments more provided by the invention, the mass ratio of Cotton Gossypii alabastrum and Cotton Gossypii nectar extract, Zein powder enzymatic hydrolyzed extract and extractive of flax seed is 5:10:20.
In other embodiments provided by the invention, the mass ratio of Cotton Gossypii alabastrum and Cotton Gossypii nectar extract, Zein powder enzymatic hydrolyzed extract and extractive of flax seed is 10:20:5.
In other embodiments provided by the invention, the mass ratio of Cotton Gossypii alabastrum and Cotton Gossypii nectar extract, Zein powder enzymatic hydrolyzed extract and extractive of flax seed is 20:5:10.
In other embodiments provided by the invention, the mass ratio of Cotton Gossypii alabastrum and Cotton Gossypii nectar extract, Zein powder enzymatic hydrolyzed extract and extractive of flax seed is 1:1:1.
As preferably, the preparation method of Cotton Gossypii alabastrum and Cotton Gossypii nectar extract is: get Cotton Gossypii alabastrum and carry out alcohol extraction, obtains Cotton Gossypii alabastrum extract; Cotton Gossypii alabastrum extract and the mixing of Cotton Gossypii nectar are obtained.
As preferably, the mass ratio of Cotton Gossypii alabastrum and Cotton Gossypii nectar is 1000:(5 ~ 20).
In embodiments more provided by the invention, the mass ratio of Cotton Gossypii alabastrum and Cotton Gossypii nectar is 1000:5.
In other embodiments provided by the invention, the mass ratio of Cotton Gossypii alabastrum and Cotton Gossypii nectar is 1000:20.
As preferably, in the preparation of Cotton Gossypii alabastrum and Cotton Gossypii nectar extract, alcohol extraction is: adopt volumn concentration to be the ethanol of 90% ~ 100%, extract under 45 ~ 55 DEG C of conditions.
As preferably, the time of Cotton Gossypii alabastrum and the alcohol extraction of Cotton Gossypii nectar extract is 1 ~ 3h.
In embodiments more provided by the invention, in the preparation of Cotton Gossypii alabastrum and Cotton Gossypii nectar extract, alcohol extraction is: adopt volumn concentration to be the ethanol of 95%, under 50 DEG C of conditions, extract 2h.
As preferably, the preparation method of Zein powder enzymatic hydrolyzed extract is: get that Zein powder carries out alcohol extraction, enzymolysis obtains.
As preferably, in the preparation of Zein powder enzymatic hydrolyzed extract, alcohol extraction is: adopt volumn concentration to be the ethanol of 90% ~ 100%, under 40 ~ 65 DEG C of conditions, extract 1 ~ 3h.
In embodiments more provided by the invention, in the preparation of Zein powder enzymatic hydrolyzed extract, alcohol extraction is: adopt volumn concentration to be the ethanol of 95%, under 50 DEG C of conditions, extract 2h.
As preferably, the enzyme that enzymolysis adopts is amylase and protease, and the time of enzymolysis is no less than 5h.As long as the consumption of amylase and protease can carry out sufficient enzymolysis to starch and albumen, do not do any restriction at this.
As preferably, the preparation method of extractive of flax seed is: get the Semen Lini dregs of fat and carry out alcohol extraction and obtain.
As preferably, in the preparation of extractive of flax seed, alcohol extraction is: adopt volumn concentration to be the ethanol of 45% ~ 55%, extract under 45 ~ 55 DEG C of conditions.
As preferably, the time of extractive of flax seed alcohol extraction is 0.5 ~ 1h, and extraction time is 1 ~ 4 time.
In embodiments more provided by the invention, in the preparation of extractive of flax seed, alcohol extraction is: adopt volumn concentration to be the ethanol of 50%, under 50 DEG C of conditions, extract 1h, filters; Filtering residue adopts volumn concentration to be the ethanol of 50%, extracts 0.5h, merge extractive liquid, under 50 DEG C of conditions.
Present invention also offers said composition and prepare the application in skin nursing products; Said composition comprises Cotton Gossypii alabastrum and Cotton Gossypii nectar extract, Zein powder enzymatic hydrolyzed extract and extractive of flax seed; As preferably, the mass ratio of Cotton Gossypii alabastrum and Cotton Gossypii nectar extract, Zein powder enzymatic hydrolyzed extract and extractive of flax seed is (5 ~ 20): (5 ~ 20): (5 ~ 20).
Present invention also offers the preparation method of said composition, comprise the steps:
The preparation of Cotton Gossypii alabastrum and Cotton Gossypii nectar extract: get Cotton Gossypii alabastrum and carry out alcohol extraction, obtains Cotton Gossypii alabastrum extract; Cotton Gossypii alabastrum extract and the mixing of Cotton Gossypii nectar are obtained;
The preparation of Zein powder enzymatic hydrolyzed extract: get Zein powder carry out alcohol extraction, enzymolysis obtain;
The preparation of extractive of flax seed: get the Semen Lini dregs of fat carry out alcohol extraction obtain;
Cotton Gossypii alabastrum and Cotton Gossypii nectar extract, Zein powder enzymatic hydrolyzed extract, extractive of flax seed are mixed, obtains compositions.
As preferably, the mass ratio of Cotton Gossypii alabastrum and Cotton Gossypii nectar is 1000:(5 ~ 20).
In embodiments more provided by the invention, the mass ratio of Cotton Gossypii alabastrum and Cotton Gossypii nectar is 1000:5.
In other embodiments provided by the invention, the mass ratio of Cotton Gossypii alabastrum and Cotton Gossypii nectar is 1000:20.
As preferably, in the preparation of Cotton Gossypii alabastrum and Cotton Gossypii nectar extract, alcohol extraction is: adopt volumn concentration to be the ethanol of 90% ~ 100%, under 45 ~ 55 DEG C of conditions, extract 1 ~ 3h.
In embodiments more provided by the invention, in the preparation of Cotton Gossypii alabastrum and Cotton Gossypii nectar extract, alcohol extraction is: adopt volumn concentration to be the ethanol of 95%, under 50 DEG C of conditions, extract 2h.
As preferably, in the preparation of Zein powder enzymatic hydrolyzed extract, alcohol extraction is: adopt volumn concentration to be the ethanol of 90% ~ 100%, under 40 ~ 65 DEG C of conditions, extract 1 ~ 3h.
In embodiments more provided by the invention, in the preparation of Zein powder enzymatic hydrolyzed extract, alcohol extraction is: adopt volumn concentration to be the ethanol of 95%, under 50 DEG C of conditions, extract 2h.
As preferably, the enzyme that enzymolysis adopts is amylase and protease, and the time of enzymolysis is no less than 5h.
As preferably, in the preparation of extractive of flax seed, alcohol extraction is: adopt volumn concentration to be the ethanol of 45% ~ 55%, and under 45 ~ 55 DEG C of conditions, extract 0.5 ~ 1h, extraction time is 1 ~ 4 time.
In embodiments more provided by the invention, in the preparation of extractive of flax seed, alcohol extraction is: adopt volumn concentration to be the ethanol of 50%, under 50 DEG C of conditions, extract 1h, filters; Filtering residue adopts volumn concentration to be the ethanol of 50%, extracts 0.5h, merge extractive liquid, under 50 DEG C of conditions.
As preferably, the mass ratio of Cotton Gossypii alabastrum and Cotton Gossypii nectar extract, Zein powder enzymatic hydrolyzed extract and extractive of flax seed is (5 ~ 20): (5 ~ 20): (5 ~ 20).
In embodiments more provided by the invention, the mass ratio of Cotton Gossypii alabastrum and Cotton Gossypii nectar extract, Zein powder enzymatic hydrolyzed extract and extractive of flax seed is 5:10:20.
In other embodiments provided by the invention, the mass ratio of Cotton Gossypii alabastrum and Cotton Gossypii nectar extract, Zein powder enzymatic hydrolyzed extract and extractive of flax seed is 10:20:5.
In other embodiments provided by the invention, the mass ratio of Cotton Gossypii alabastrum and Cotton Gossypii nectar extract, Zein powder enzymatic hydrolyzed extract and extractive of flax seed is 20:5:10.
In other embodiments provided by the invention, the mass ratio of Cotton Gossypii alabastrum and Cotton Gossypii nectar extract, Zein powder enzymatic hydrolyzed extract and extractive of flax seed is 1:1:1.
Present invention also offers a kind of skin nursing products, comprise compositions provided by the invention; Said composition comprises Cotton Gossypii alabastrum and Cotton Gossypii nectar extract, Zein powder enzymatic hydrolyzed extract and extractive of flax seed; As preferably, the mass ratio of Cotton Gossypii alabastrum and Cotton Gossypii nectar extract, Zein powder enzymatic hydrolyzed extract and extractive of flax seed is (5 ~ 20): (5 ~ 20): (5 ~ 20).
In embodiments more provided by the invention, skin is scalp and/or skin.
The invention provides a kind of skin care compositions and methods and application thereof, preparation method, product.Said composition comprises Cotton Gossypii alabastrum and Cotton Gossypii nectar extract, Zein powder enzymatic hydrolyzed extract and extractive of flax seed.The present invention at least has one of following advantage:
The present composition obviously can increase stratum corneum thickness, and obviously increases moisture of skin, and compatibility is reasonable, and use safety is non-stimulated;
When the dosage of the present composition is few compared to single extract component, effect is more remarkable on the contrary, and each component in conjunction uses can produce obvious synergistic function;
The present composition obviously can promote that skin resides the increment of probiotics, and temporarily harmful bacteria is stayed to skin and conditioned pathogen inhibited, thus probiotic bacteria is had the advantage status, promotes skin microecological balance;
The present composition and product are scalp, the skin nursing formula of pure natural, select natural Cotton Gossypii alabastrum and nectar extract, Zein powder enzymatic hydrolyzed extract (containing oligosaccharide and polypeptide), compatibility Semen Lini multiple extractiuon thing, the scalp made, skin nursing product can increase scalp, skin cuticle thickness, and improve scalp, skin microorganism species, long-acting, the gentle nursing of skin can be realized, be a kind of safe and effective, compatibility rationally, the skin nursing products that have no side effect, be particularly suitable for baby and need gentle skin nursing crowd to use.
Detailed description of the invention
The invention discloses a kind of skin care compositions and methods and application thereof, preparation method, product, those skilled in the art can use for reference present disclosure, and suitable improving technique parameter realizes.Special needs to be pointed out is, all similar replacements and change apparent to those skilled in the art, they are all deemed to be included in the present invention.Method of the present invention and application are described by preferred embodiment, related personnel obviously can not depart from content of the present invention, spirit and scope methods and applications as herein described are changed or suitably change with combination, realize and apply the technology of the present invention.
In skin care compositions and methods provided by the invention and application thereof, preparation method, product, raw materials used or adjuvant all can be buied by market or farm.
Below in conjunction with embodiment, set forth the present invention further:
The preparation of embodiment 1 Cotton Gossypii alabastrum and Cotton Gossypii nectar extract
1000 kilograms, the fresh alabastrum of Cotton Gossypii, after pulverizing, adds 1000 kilogram of 95% edible ethanol, is heated to 50 ± 5 DEG C, stirs extraction 2 hours, and cross leaching filtrate, filtrate decompression vacuum concentration recovered alcohol, obtains concentrated solution 200Kg.Cotton Gossypii nectar 5Kg is added, obtained Cotton Gossypii alabastrum and Cotton Gossypii nectar extract 205Kg, admittedly containing thing 25%-30%, be designated HME-1 to 200Kg concentrated solution.
The preparation of embodiment 2 Cotton Gossypii alabastrum and Cotton Gossypii nectar extract
1000 kilograms, the fresh alabastrum of Cotton Gossypii, after pulverizing, adds 1000 kilogram of 95% edible ethanol, is heated to 50 ± 5 DEG C, stirs extraction 2 hours, and cross leaching filtrate, filtrate decompression vacuum concentration recovered alcohol, obtains concentrated solution 200Kg.Cotton Gossypii nectar 20Kg is added, obtained Cotton Gossypii alabastrum and Cotton Gossypii nectar extract 220Kg, admittedly containing thing 25%-30%, be designated HME-2 to 200Kg concentrated solution.
The preparation of embodiment 3 zein enzymatic hydrolyzed extract
Zein powder 200Kg adds 1000Kg95% edible ethanol, and 50 ± 5 DEG C of heated and stirred are extracted, and filter decolouring.After decolouring, Zein powder adds 2000Kg pure water, make suspension, heated and boiled is cooled to 55 DEG C after within 1 hour, making albuminous degeneration, add amylase and proteolytic enzyme, be hydrolyzed 5 hours, hydrolyzed solution ceramic membrane filter, ceramic membrane filter liquid is through RO membrance concentration, concentrated solution concentrates through reduced vacuum again, obtained zein enzymatic hydrolyzed extract 200Kg, admittedly containing thing 20-30%, be labeled as DBE.
The preparation of embodiment 4 extractive of flax seed
Semen Lini material slag 200Kg after liquefaction, add 2000Kg50% ethanol water, 50 ± 5 DEG C of heated and stirred extract 1 hour, filter, filtering residue continues to add 800Kg50% ethanol water, 50 ± 5 DEG C are stirred extraction and filter for 30 minutes, and merge extractive liquid, after extracting solution reduced vacuum concentration and recovery ethanol, concentrated solution centrifugal filtration, obtained extractive of flax seed 200Kg, admittedly containing thing 15-20%, be labeled as YME.
The preparation of embodiment 5 care composition
0.5Kg embodiment 1 Cotton Gossypii alabastrum and Cotton Gossypii nectar extract HME-1,1Kg embodiment 3 zein enzymatic hydrolyzed extract DBE, 2Kg embodiment 4 extractive of flax seed YME, 6.5Kg pure water, stirs, and makes 10Kg care composition, is labeled as HLY-1.
The preparation of embodiment 6 care composition
1Kg embodiment 1 Cotton Gossypii alabastrum and Cotton Gossypii nectar extract HME-1,2Kg embodiment 3 zein enzymatic hydrolyzed extract DBE, 0.5Kg embodiment 4 extractive of flax seed YME, 6.5Kg pure water, stirs, and makes 10Kg care composition, is labeled as HLY-2.
The preparation of embodiment 7 care composition
2Kg embodiment 1 Cotton Gossypii alabastrum and Cotton Gossypii nectar extract HME-1,0.5Kg embodiment 3 zein enzymatic hydrolyzed extract DBE, 1Kg embodiment 4 extractive of flax seed YME, 6.5Kg pure water, stirs, and makes 10Kg care composition, is labeled as HLY-3.
The preparation of embodiment 8 care composition
0.5Kg embodiment 2 Cotton Gossypii alabastrum and Cotton Gossypii nectar extract HME-2,0.5Kg embodiment 3 zein enzymatic hydrolyzed extract DBE, 0.5Kg embodiment 4 extractive of flax seed YME, 8.5Kg pure water, stirs, and makes 10Kg conditioning liquid product HLY-4.
The preparation of embodiment 9 care composition
1Kg embodiment 2 Cotton Gossypii alabastrum and nectar extract HME-2,1Kg embodiment 3 zein enzymatic hydrolyzed extract DBE, 1Kg embodiment 4 extractive of flax seed YME, 7Kg pure water, stirs, and makes 10Kg conditioning liquid product HLY-5.
The preparation of embodiment 10 care composition
2Kg embodiment 2 Cotton Gossypii alabastrum and nectar extract HME-2,2Kg embodiment 3 zein enzymatic hydrolyzed extract DBE, 2Kg embodiment 4 extractive of flax seed YME, 4Kg pure water, stirs, and makes 10Kg conditioning liquid product HLY-6.
The preparation of embodiment 11 reference product
6Kg embodiment 1 Cotton Gossypii alabastrum and nectar extract HME-2, mixing 4Kg pure water, stirs, makes 10Kg reference product DZP-1.
The preparation of embodiment 12 reference product
6Kg embodiment 3 zein enzymatic hydrolyzed extract DBE, mixing 4Kg pure water, stirs, makes 10Kg reference product DZP-2.
The preparation of embodiment 13 reference product
6Kg embodiment 4 extractive of flax seed YME, mixing 4Kg pure water, stirs, makes 10Kg reference product DZP-3.
Embodiment 14 product efficacy is tested
The test of skin nursing efficacy test is launched to above embodiment 5-13 product.
(1) skin adhesive band tears and pastes test and result
Recruit 25-45 year female volunteers totally 100, and be divided into 10 groups at random, often organize 10 people.Use HLY-1, HLY-2, HLY-3, HLY-4, HLY-5, HLY-6, DZP-1, DZP-2, DZP-3 product, and deionized water (blank), be distributed to 8 groups of experimenters at random, carries out skin adhesive band and tear subsides double-blind trial.At experimenter's forearm sooner or later respectively once, 2mg/cm
2, after seven days, arm adhesive tape tears subsides 10 times, uses Vivascope counting and cuticle thickness and constructed observation, and testing skin capacitance, to calculate skin beauty water right.
Before and after table 1 uses, stratum corneum thickness change is relative with electric capacity changes
In table 1, result of the test shows that product HLY-1, HLY-2, HLY-3, HLY-4, HLY-5, HLY-6 of the present invention are relative to pure water and relative to three reference substances using single extract component, obviously can increase stratum corneum thickness, and obviously increase moisture of skin, and use safety is non-stimulated.And when the dosage of product of the present invention is few compared to single extract component, effect is more remarkable on the contrary, therefore in product of the present invention, each component in conjunction uses and can produce obvious synergistic function.
(2) skin flora control agent is tested outward and result
Test method:
1) respectively by staphylococcus epidermidis (ATCC12228), staphylococcus aureus (ATCC6538) is inoculated in nutrient broth medium, and propionibacterium acnes (ATCC6919) is inoculated in GAM culture medium.
2) often kind of a culture fluid gets 10mL, each 7 parts, adds HLY-1, HLY-2, HLY-3, HLY-4, HLY-5, HLY-6 and 0.1mL deionized water of 0.1mL respectively;
3) by staphylococcus epidermidis, staphylococcus aureus as the aerobic cultivation of 24h at 37 DEG C, by propionibacterium acnes as 48h Anaerobic culturel at 37 DEG C;
4) number cultivating the various bacterium in front and back is measured with dilution-plate method.
Result of the test is in table 2:
Front and back skin microbial number of variations cultivated by table 2
Table 2 data show, product HLY-1, HLY-2, HLY-3, HLY-4, HLY-5, HLY-6 of the present invention are compared to blank, obviously can promote that skin resides the increment of probiotics (taking staphylococcus epidermidis as representative), and to skin temporarily stay harmful bacteria (taking staphylococcus aureus as representative) and conditioned pathogen (taking propionibacterium acnes as representative) inhibited, thus probiotic bacteria is had the advantage status, promote skin microecological balance.
The preparation of embodiment 15 scalp care cosmetics
Example 1 Cotton Gossypii alabastrum and Cotton Gossypii nectar extract HME-1, embodiment 3 zein enzymatic hydrolyzed extract DBE, embodiment 4 extractive of flax seed YME mix with cosmetics customary adjuvant, conveniently technique, obtained scalp care cosmetics.
The preparation of embodiment 16 skin nursing cosmetics
Example 2 Cotton Gossypii alabastrum and Cotton Gossypii nectar extract HME-1, embodiment 3 zein enzymatic hydrolyzed extract DBE, embodiment 4 extractive of flax seed YME mix with cosmetics customary adjuvant, conveniently technique, obtained skin nursing cosmetics.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (10)
1. a compositions, is characterized in that, comprises Cotton Gossypii alabastrum and Cotton Gossypii nectar extract, Zein powder enzymatic hydrolyzed extract and extractive of flax seed.
2. compositions according to claim 1, it is characterized in that, the mass ratio of described Cotton Gossypii alabastrum and Cotton Gossypii nectar extract, described Zein powder enzymatic hydrolyzed extract and described extractive of flax seed is (5 ~ 20): (5 ~ 20): (5 ~ 20).
3. compositions is preparing the application in skin nursing products as claimed in claim 1 or 2.
4. the preparation method of compositions as claimed in claim 1 or 2, is characterized in that, comprise the steps:
The preparation of Cotton Gossypii alabastrum and Cotton Gossypii nectar extract: get Cotton Gossypii alabastrum and carry out alcohol extraction, obtains Cotton Gossypii alabastrum extract; Described Cotton Gossypii alabastrum extract and the mixing of Cotton Gossypii nectar are obtained;
The preparation of Zein powder enzymatic hydrolyzed extract: get Zein powder carry out alcohol extraction, enzymolysis obtain;
The preparation of extractive of flax seed: get the Semen Lini dregs of fat carry out alcohol extraction obtain;
Described Cotton Gossypii alabastrum and Cotton Gossypii nectar extract, described Zein powder enzymatic hydrolyzed extract, described extractive of flax seed are mixed, obtains compositions.
5. preparation method according to claim 4, is characterized in that, the mass ratio of described Cotton Gossypii alabastrum and Cotton Gossypii nectar is 1000:(5 ~ 20).
6. preparation method according to claim 4, is characterized in that, in the preparation of described Cotton Gossypii alabastrum and Cotton Gossypii nectar extract, alcohol extraction is: adopt volumn concentration to be the ethanol of 90% ~ 100%, extract under 45 ~ 55 DEG C of conditions.
7. preparation method according to claim 4, is characterized in that, the enzyme that described enzymolysis adopts is amylase and protease, and the time of enzymolysis is no less than 5h.
8. preparation method according to claim 4, is characterized in that, in the preparation of described extractive of flax seed, alcohol extraction is: adopt volumn concentration to be the ethanol of 45% ~ 55%, extract under 45 ~ 55 DEG C of conditions.
9. skin nursing products, is characterized in that, comprise compositions described in claim 1 or 2.
10. skin nursing products according to claim 9, is characterized in that, described skin is scalp and/or skin.
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