CN105148363B - A kind of device of pulmonary disease spray delivery - Google Patents
A kind of device of pulmonary disease spray delivery Download PDFInfo
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- CN105148363B CN105148363B CN201510446625.5A CN201510446625A CN105148363B CN 105148363 B CN105148363 B CN 105148363B CN 201510446625 A CN201510446625 A CN 201510446625A CN 105148363 B CN105148363 B CN 105148363B
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Abstract
A kind of pulmonary disease spray delivery device, including bottom cover, lower part set the lower shell of lower spring, and medicine bottle is placed in lower spring, medicine bottle mouth and motion block card and, a pipette sequentially passes through quiet piece, upper spring, motion block and is inserted into medicine bottle from top to bottom；Pipette is fixed in motion block upper end, and check valve is mounted in pipette top, and trickle nozzle and filter are installed in quiet piece of top；The upper shell of top tape suction nozzle is sleeved on outside quiet piece and upper spring, upper press cover is connected on upper shell, coat suit is in upper shell lower part and lower shell top, there is a circle power assistant spring between lower shell and overcoat, overcoat lower part is inwardly along the circumferential direction provided with a circle and the groove of lower shell perforation, perforate on groove, it is each in hole to place a steel ball, along the circumferential direction it is provided with bayonet at motion block top 1/3；A piece screw rod is fixed on the coat, and counting scale is carved with screw rod lower end by fine thread concatenation pointer, pointer surrounding.The present invention direct oral cavity that can repeatedly spray is administered lung.
Description
Technical field
The present invention relates to technical field of medical instrument, more particularly to a kind of Respiratory Medicine, it is on pulmonary disease, can
With spray inhalation administration device that is quantitative, repeatedly spraying.
Background technology
In recent years since the factors such as serious problem of environmental pollution, air pollution constantly deteriorate so that chronic obstructive pulmonary
The incidence of disease (COPD), asthma and some breathing problems is in rising situation.
But it can not all cause medicine for pulmonary disease, or breathing problem, drug administration, or injection
Lesion is directly acted on, on the contrary by numerous organs such as liver, into systemic blood circulation.The organs such as liver often have first cross to imitate
Should, i.e., oneself and unwanted drug absorption have been damaged these organs by they on the contrary.At present in the world, some flourishing states
Treatment of the family for pulmonary disease has been introduced into the stage by directly medicine being sucked by respiratory tract lung.It is this by exhaling
Road is inhaled directly by drug effect in the medication good effect of lung, it is quick, medicine can be made to directly act on lesion, for
Other position Small side effects of body, are a kind of very advanced medications.
Pulmonary administration accumulates big, absorption site blood flow with sorbent surface and enriches, can avoid liver first-pass effect and epithelium
The advantages that barrier is thin, membrane permeability is high, therapeutic domain is expanding, and is more and more paid attention to.
Spraying suction pulmonary administration has many superiority, and Inhalation in Treating first can make medicine directly get to target device
The lung and bronchus of official, i.e. patient, therefore it is required that lung and bronchial local concentration higher, action speed faster, so can be with
Alleviate the symptom of patients with COPD in a short time.Secondly, the dosage of inhalation-type drug administration institute drug is than oral and injection institute
Need the dosage of medicine much smaller.For example, general oral drugs need 8 milligrams and Sucked medicine only needs 0.2 milligram, although inhaling
The dosage for entering medicine is oral 1/40, but effect is more preferable for the air flue of chronic obstructive pulmonary disease, and to the side effect of whole body
Smaller.Secondly, the chemical degradation and enzyme degradation reaction of lung are relatively low, therefore the degree that medicine is destroyed is small.Adult there are about 3~4
Hundred million alveolars, the gross area is up to 7~100 square metres, and the effective surface area of mucous membrane of small intestine microvilli is roughly the same, can be efficient
The larger proteins and peptides medicine of delivery molecule quality.Huge respiratory surface is the basis that lung has good absorption ability.
It has been recognized that inhalation is the method for administration the most simple and effective for treating above-mentioned disease.Suck at the same time
Treatment can be additionally used in the treatment of other pulmonary infections such as influenza, lung cancer.
The RESPIMAT atomized medicine introducing devices that German Bo Linge Yin Ge companies (Boehringer-ingelheim) are released are
It is quantitative most accurate in the world at present, using most convenient, the longer drug delivery device of nebulisation time.The COPD new drugs of the said firm's exploitation
Spiriva Respimat have successfully been obtained the approval of FDA in part of in September, 2014.The medicine uses that not depend on air quick
Delivered by way of inhalator, but lesion is directly acted on through respiratory tract by oral cavity by a kind of aerosol slowly delivered
New method.Can be found pleasure in the suction apparatus of (Respimat) exactly as this newtype drug again, can be allowed with the characteristic of its " soft mist "
Patient sucks the subparticle of atomization at leisure, improves deposition of the medicine in lung, while be easily chronic obstructive pulmonary disease, asthmatic patient institute
Receive.
The many drug research units in China have researched and developed the medicine for being used directly for inhalation therapy, are badly in need of corresponding
Drug delivery device that can be supporting.
The content of the invention
The demand of shortage and market for the drug delivery device of China's independent development, the present invention provide one kind for lung's disease
Spray inhalation administration device that is sick, can quantifying and repeatedly spray.
The present invention is achieved by the following technical solutions：
A kind of pulmonary disease spray delivery device, it is characterised in that the device includes：Sealed by bottom cover under lower end
Cylinder, lower spring are arranged at the lower part in lower shell, and medicine bottle is placed in lower spring, the motion block above medicine bottle by its lower end with
The card slot and medicine bottle card and connection that medicine bottle bottleneck mutually agrees with；Slave Block sets gradually spring and one quiet piece, an imbibition upwards
Pipe sequentially passes through quiet piece, upper spring, motion block and is inserted into medicine bottle from top to bottom；
Pipette is clamped to motion block upper end by clamping device, and the sealing gland with sealing ring is set in pipette
On be connected to quiet piece of lower end, pipette upper end is equipped with a check valve below filter, and filter is put into trickle nozzle lower part, carefully
Micro-nozzle base stretches out quiet piece of top and is connected with quiet piece；One upper shell is sleeved on outside quiet piece and upper spring, at the top of upper shell to
On extend a suction nozzle；One upper press cover is connected on upper shell, downward from upper press cover edge, an overcoat for carrying upper flange
Upper shell and lower shell top are sleeved on, is provided with a circle power assistant spring between lower shell and overcoat, lower shell lower part is along one
A circumferencial direction is provided with 3~6 apertures, and a steel ball is respectively placed in aperture, be sleeved on outside with steel ball corresponding position along the circumferential direction on
A circle and the groove of lower shell perforation are provided with, a circle bayonet is along the circumferential direction provided with motion block top 1/3；At motion block top 1/3
Along the circumferential direction it is provided with a circle bayonet；
A piece screw rod is fixed on the coat, and by fine thread concatenation pointer, pointer surrounding, which is carved with numeration, carves for screw rod lower end
Degree.
The bottleneck of the medicine bottle is equipped with sealing ring, and a gasket seals bottleneck.
The upper press cover and upper shell, which can use, to be threadedly coupled, is cementing or snap connection.
The sealing gland can be used with quiet piece to be threadedly coupled, is cementing or snap connection.
The suction nozzle is equipped with a protective case.
The clamping device is mechanical gripping devices, and the gasket ring of a fluting is tightened using nut, pipette is consolidated
It is scheduled in motion block.
Beneficial effect
The spray delivery device of pulmonary disease inhalation therapy of the present invention, has following features：
(1) upper and lower two springs are housed in drug delivery device.When pressing drug delivery device, upper and lower two springs are pressed at the same time
Contracting.Lower spring has a clamp, temporarily blocks lower spring when compressing in place.And upper spring does not have clamp, in pressing
Afterwards, upper spring can discharge automatically.
(2) pipette is fixed together with motion block, and motion block is as big piston, and pipette is as valve piston, in quiet piece
Liquid is pressurized to high pressure.
(3) spring promotes quiet piece in release on, namely high pressure piston cylinder moves forward, and at this moment check valve is opened, imbibition
Pipe draws the liquid of ormal weight in high pressure piston cylinder out of medicine bottle.
(4) after drug delivery device is contained into mouth, release button is pressed, lower spring release, promotes big piston to move forward,
Big piston driving valve piston, plays the role of pressure multiplier, and the liquid in valve piston is pressurizeed into high pressure liquid.
(5) high pressure liquid is atomized into the liquid of atomization shape by minute nozzle.With the suction action of mouth, atomization
Liquid is drawn onto lung, allows the fine liquid of atomization to be applied directly to the focal area of lung.Play most direct therapeutic effect.
Brief description of the drawings
Fig. 1 is schematic diagram of the spray delivery device in collecting state.
Wherein, 1：Bottom cover, 2：Lower spring, 3：Medicine bottle, 4：Lower shell, 5：Pipette, 6：Sealing ring, 7：Gasket, 8：Steel
Pearl, 9：Motion block, 10：Overcoat, 11：Bayonet, 12：Power assistant spring, 13：Clamping device, 14：Upper spring；15：Sealing gland, 16：O
Type circle, 17：Upper flange, 18：Upper press cover, 19：Quiet piece, 20：Upper shell, 21：Check valve, 22：Filter, 23：Trickle nozzle,
24：Suction nozzle.
Fig. 2 is the schematic diagram at the spray delivery device back side, it can be seen that counting scale and its pointer.
Wherein, 25：Screw rod, 26：Pointer, 27：Protective case.
Fig. 3 is the schematic diagram for the first step for operating drug delivery device
Fig. 4 is the schematic diagram for the second step for operating drug delivery device
Fig. 5 is the schematic diagram for the 3rd step for operating drug delivery device
Embodiment
With reference to embodiment, the present invention is further elaborated.
As shown in Figure 1, when starting medication, medicine bottle 3 can be loaded by removing bottom cover 1.The bottle cap of medicine bottle 3 is taken away, is put vertically
On the table, medicine bottle is put into inner cylinder 4, allows pipette 5 to be inserted into medicine bottle.Vertical pressing drug delivery device, lower spring are compressed, can
Medicine bottle is pressed into bottleneck sealing ring 6, and compression is contacted with bottle sealing pad 7, at this moment medicine bottle just loads drug delivery device.Bottleneck is close
Seal 6 and bottle sealing pad 7 cause the liquid in medicine bottle not leak out.Bottom cover 1 is loaded onto, this drug delivery device can just make
With.
During medication, drug delivery device upper shell 20 is held, is down pressed, be provided with bayonet 11 on motion block 9, motion block is past during pressing
Lower movement, compresses lower spring 2, until bayonet 11 runs into steel ball, is blocked temporarily by steel ball.At this moment spring is compressed at the same time up and down.
Referring to Fig. 3.
When idle state, steel ball is in the steel bead groove of the steel ball hole of lower shell and overcoat, is preparing to be administered
When, on pressing cylinder top, steel ball is snapped into the steel bead groove between inner cylinder and motion block temporarily so that lower spring is in compression shape
Temporarily pinned under state, once axially applying some thrusts, steel ball can skid off in the groove of Slave Block at once, so that under discharging
Spring.
Pressing is decontroled, since upper spring 14 is not stuck, it can loosen automatically.Upper spring can be by quiet piece 19 when loosening
Up release, at this moment moved equivalent to pipette 5 as piston within piston cylinder, i.e., quiet piece 19.At this moment check valve 21 is opened,
The liquid of ormal weight is sucked when upper spring 14 promotes quiet piece 19 movement.Referring to Fig. 4.
The suction nozzle 24 of drug delivery device is contained in the mouth.Pinched with hand and upper flange 17 and upper press cover 18 are covered outside pressure, in overcoat
Power assistant spring 12 is compressed, and has been played power-assisted promotion, axial thrust has been applied on the steel ball 8 being stuck in bayonet.By
State is blocked in unstable in steel ball 8, once being subject to axial thrust, steel ball can be skidded off out of bayonet 11 so that lower spring 2
Drastically recover the state compressed.The spring force of outburst drastically up promotes the pipette 5 on 9 related motion block of motion block, the suction
Liquid pipe 5 is can to bear the thick-walled pipe of high pressure, it has played piston in quiet piece 19.Pipette 5 must be mutual with motion block 9
Fixed, 13 be the clamping device being clamped to pipette 5 on motion block 9.15 and 16 be at quiet piece using pipette as piston
The dynamic sealing device of movement in 19.Wherein 16 be O-ring, and 15 be sealing gland.Cycle spring 12 is to be risen under release in spring 2
The effect that power-assisted promotes.Lower spring 2 promotes motion block and pipette to move together, and motion block 9 plays the role of one big piston, and
The pipette 5 done by high pressure thick-walled pipe plays the role of valve piston in quiet piece 19.It plays pipette in lower part, and
The top of pipette, coordinates with check valve, plays the role of high-pressure mini piston.
Large and small piston plays the role of pressure multiplier, the liquid of suction is pressurized to the state of high pressure.The liquid warp of high pressure
Minute nozzle passage is crossed, medical liquid atomizing is drawn onto in lung, completes the process of administration.The state that injection is completed may refer to Fig. 5.
Fig. 2 shows the counting device that can be worked asynchronously with drug delivery device.While energizing spring is pressed, screw rod 25
Driven while pressing by nut and rotate a circle so that the pointer 26 on screw thread is passed by a pitch.When spring discharges, push away
The dynamic rotating nut of screw unclamps, so pointer can only one-way movement.It indicates compression number, represents making for drug delivery device
Use number.
Fig. 3 is the first step for operating drug delivery device：Pressing, at this moment spring is all compressed up and down, and lower spring 2 is by steel ball 8
It is stuck in bayonet 11, will not temporarily discharges.And upper spring 14 is not stuck, can be discharged automatically after pressing.
Fig. 4 is the second step of operation：Wait, only need several seconds clock time, at this moment upper spring 14 has discharged completion, and piston moves back
To the end, it is actually piston cylinder, namely quiet piece 19 is shifted onto topmost, and at this moment check valve is in opening, toward in pipette
It is pumped into the liquid of ormal weight.
Fig. 5 is the 3rd step of operation：Injection, pinches flange 17 and upper press cover 18 on pressure overcoat 10, equivalent to quiet piece of promotion
19 and motion block 9, allow the steel ball 8 on motion block 9 to skid off bayonet 11, the spring 12 in overcoat has played power-assisted.Lower spring 2 is being released
When putting, motion block 9 has been promoted, the pipette 5 on motion block 9, this is high pressure thick-walled pipe, has risen and has been used as big piston by motion block 9, drives and inhales
Liquid pipe 5 is used as valve piston, compresses quiet piece 19 as the liquid in piston cylinder, liquid is pressurized to high pressure conditions, high pressure liquid warp
Filter 22 is crossed, into minute nozzle 23, (trickle cap of spraying nozzle can the fine gap for adjusting nozzle) be inhaled into after being atomized immediately
Therapeutic effect is played in lung.
After completing above-mentioned steps, 24 wiped clean of suction nozzle puts on protective case 27, to protect suction nozzle cleaning.
The present invention adjusts the dose that pipette sucks by the stroke of regulating piston, that is, adjusts quiet piece between motion block
Distance can correspond to different suction doses.Since dosage is dosage as defined in doctor's advice, the regulation by manufacturer according to medicine
Set, user cannot voluntarily adjust dosage.
Claims (5)
1. a kind of pulmonary disease spray delivery device, it is characterised in that the device includes：The lower cylinder of lower end is sealed by bottom cover
Body, lower spring are arranged at the lower part in lower shell, and medicine bottle is placed in lower spring, the motion block above medicine bottle by its lower end and medicine
The card slot and medicine bottle card and connection that bottle bottleneck mutually agrees with；Slave Block sets gradually spring and one quiet piece, a pipette upwards
Quiet piece is sequentially passed through from top to bottom, upper spring, motion block and is inserted into medicine bottle；
Pipette is clamped to motion block upper end by clamping device, and the sealing gland with sealing ring, which is set in pipette, to be connected
Quiet piece of lower end is connected on, pipette upper end is equipped with a check valve below filter, and filter is put into trickle nozzle lower part, trickle spray
Gonys seat stretches out quiet piece of top and is connected with quiet piece；One upper shell is sleeved on outside quiet piece and upper spring, is prolonged upwards at the top of upper shell
Stretch out a suction nozzle；One upper press cover is connected on upper shell, downward from upper press cover edge, a coat suit for carrying upper flange
In upper shell and lower shell top, a power assistant spring is provided between lower shell and overcoat, lower shell lower part is along a circle
Circumferential direction is provided with 3~6 apertures, and a steel ball has respectively been placed in aperture, is sleeved on is opened with steel ball corresponding position on along the circumferential direction outside
There are a circle and the groove of lower shell perforation, a circle bayonet is along the circumferential direction provided with motion block top 1/3；
A piece screw rod is fixed on the coat, and numeration scale is carved with screw rod lower end by fine thread concatenation pointer, pointer surrounding.
2. pulmonary disease spray delivery device as claimed in claim 1, it is characterised in that the bottleneck of the medicine bottle is equipped with
Sealing ring, a gasket seal bottleneck.
3. pulmonary disease spray delivery device as claimed in claim 1, it is characterised in that the upper press cover and upper shell
Connection mode is is threadedly coupled, cementing or in snapping connection one kind；The sealing gland is with quiet piece of connection mode
It is threadedly coupled, cementing or in snapping connection one kind.
4. pulmonary disease spray delivery device as claimed in claim 1, it is characterised in that the suction nozzle is equipped with a protection
Set.
5. pulmonary disease spray delivery device as claimed in claim 1, it is characterised in that the clamping device is mechanical
Clamping device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510446625.5A CN105148363B (en) | 2015-07-27 | 2015-07-27 | A kind of device of pulmonary disease spray delivery |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510446625.5A CN105148363B (en) | 2015-07-27 | 2015-07-27 | A kind of device of pulmonary disease spray delivery |
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| Publication Number | Publication Date |
|---|---|
| CN105148363A CN105148363A (en) | 2015-12-16 |
| CN105148363B true CN105148363B (en) | 2018-04-27 |
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ID=54789611
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510446625.5A Active CN105148363B (en) | 2015-07-27 | 2015-07-27 | A kind of device of pulmonary disease spray delivery |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111214381B (en) * | 2020-01-13 | 2022-03-08 | 安徽理工大学 | Multifunctional medicinal nozzle and use method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103272730A (en) * | 2005-08-24 | 2013-09-04 | 贝林格尔.英格海姆国际有限公司 | Atomiser |
| CN103582505A (en) * | 2011-05-23 | 2014-02-12 | 勃林格殷格翰国际有限公司 | Nebulizer |
| CN104058180A (en) * | 2013-03-18 | 2014-09-24 | 梁敬玉 | Dosage dispenser |
| CN205041923U (en) * | 2015-07-27 | 2016-02-24 | 华东理工大学 | Device that lung's disease spraying was dosed |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9943654B2 (en) * | 2010-06-24 | 2018-04-17 | Boehringer Ingelheim International Gmbh | Nebulizer |
-
2015
- 2015-07-27 CN CN201510446625.5A patent/CN105148363B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103272730A (en) * | 2005-08-24 | 2013-09-04 | 贝林格尔.英格海姆国际有限公司 | Atomiser |
| CN103582505A (en) * | 2011-05-23 | 2014-02-12 | 勃林格殷格翰国际有限公司 | Nebulizer |
| CN104058180A (en) * | 2013-03-18 | 2014-09-24 | 梁敬玉 | Dosage dispenser |
| CN205041923U (en) * | 2015-07-27 | 2016-02-24 | 华东理工大学 | Device that lung's disease spraying was dosed |
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| Publication number | Publication date |
|---|---|
| CN105148363A (en) | 2015-12-16 |
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