CN105148089A - Traditional Chinese medicine composition for clearing and nourishing throat - Google Patents
Traditional Chinese medicine composition for clearing and nourishing throat Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for clearing and nourishing throat, as well as a granular preparation, a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises immature fruits of terminalia chebula, roots of platycodon grandiflorus, caulis bambusae in taeniam, dry mature seeds of sterculia lychnophora Hance, exocarpium citri rubrum, fructus aurantii, folium mori, dry rhizome of cyperus rotundus, fructus perillae, dry stems of perilla frutescens, agilawood, menthol, American ginseng and momordica grosvenori. The traditional Chinese medicine composition has few side effects to the human body, does not harm stomach, and can be used for a long time to protect vocal cords. The granular preparation prepared from the traditional Chinese medicine composition comprises 0.01-0.25 wt% of lactose, 0.03-0.75 wt% of mannitol, and 0.02-0.50 wt% of sodium benzoate, and the weight ratio of the lactose to the mannitol to the sodium benzoate is 1:3:2. According to the invention, the lactose, the mannitol and the sodium benzoate are adopted as auxiliary materials, and the granular preparation prepared through rational combination of the auxiliary materials is good in stability, high in dissolving speed, has good antibacterial performance, and can effectively relieve bitter taste of traditional Chinese medicines.
Description
Technical field
The present invention relates to Chinese medicine composition field, particularly relate to a kind of Chinese medicine composition and granule thereof of cleaning throat and moistening larynx.
Background technology
The cause of disease of having sore throat has multiple, and affection of exogenous wind-cold, long-time speech etc. all can make throat not feel well, and then cause hoarseness etc.Especially voice worker, throat is most important protection position, needs regular or irregularly to carry out medicine maintenance to throat; the existing medicine that wets one's whistle, adds wherein mainly with Radix Scutellariae as monarch drug greatly, and Radix Scutellariae has effect of clearing away heat-fire removing toxic substances; but; Radix Scutellariae bitter cold injures one's stomach, and Deficiency and coldness of spleen and stomach person should not use, slightly poisonous; owing to wetting one's whistle, medicine belongs to common medicine; commonly use and can protect vocal cords, if the medicine that wets one's whistle containing Radix Scutellariae is commonly used, then can bring the side effect such as bitter cold injures one's stomach to user.Especially to old man and child, should not use.Meanwhile, when this medicine is made granule, the use of adjuvant is most important, directly affects the shapes such as the stability of medicine, dissolubility.
Summary of the invention
The shortcoming of prior art in view of the above, the object of the present invention is to provide a kind of Chinese medicine composition of cleaning throat and moistening larynx, cold excessively strong for solving in prior art the medicine that wets one's whistle, life-time service can bring the side effect such as bitter cold injures one's stomach to human body and corresponding granule is not soluble, the problem of poor stability.
For achieving the above object and other relevant objects, first aspect present invention provides a kind of Chinese medicine composition of cleaning throat and moistening larynx, comprises the component of following weight portion:
FRUCTUS TERMINALIAE IMMATURUS 60-90 part;
Radix Platycodonis 40-60 part;
Caulis Bambusae In Taenia 40-60 part;
Semen Sterculiae Lychnophorae 20-30 part;
Exocarpium Citri Rubrum 30-45 part;
Fructus Aurantii 25-40 part;
Folium Mori 15-30 part;
Rhizoma Cyperi (processed with vinegar) 20-40 part;
Fructus Perillae 10-25 part;
Caulis Perillae 8-15 part;
Lignum Aquilariae Resinatum 20-30 part;
Mentholum 5-10 part;
Radix Panacis Quinquefolii 6-11 part;
Fructus Momordicae 8-12 part.
Further, described FRUCTUS TERMINALIAE IMMATURUS: Radix Platycodonis: Caulis Bambusae In Taenia: Semen Sterculiae Lychnophorae=3:2:2:1, described ratio is weight ratio.Further, the component of following weight portion is comprised:
FRUCTUS TERMINALIAE IMMATURUS 69-81 part;
Radix Platycodonis 46-54 part;
Caulis Bambusae In Taenia 46-54 part;
Semen Sterculiae Lychnophorae 23-27 part;
Exocarpium Citri Rubrum 35-40 part;
Fructus Aurantii 30-35 part;
Folium Mori 20-25 part;
Rhizoma Cyperi (processed with vinegar) 25-35 part;
Fructus Perillae 15-20 part;
Caulis Perillae 10-13 part;
Lignum Aquilariae Resinatum 22-26 part;
Mentholum 7-9 part;
Radix Panacis Quinquefolii 6-9 part;
Fructus Momordicae 10-12 part.
Further, the component of following weight portion is comprised:
FRUCTUS TERMINALIAE IMMATURUS 75 parts;
Radix Platycodonis 50 parts;
Caulis Bambusae In Taenia 50 parts;
Semen Sterculiae Lychnophorae 25 parts;
Exocarpium Citri Rubrum 37 parts;
Fructus Aurantii 33 parts;
23 parts, Folium Mori;
Rhizoma Cyperi (processed with vinegar) 30 parts;
Fructus Perillae 18 parts;
Caulis Perillae 12 parts;
Lignum Aquilariae Resinatum 25 parts;
Mentholum 8 parts;
Radix Panacis Quinquefolii 8 parts;
Fructus Momordicae 11 parts.
Second aspect present invention provides a kind of Chinese medicine extract, is extracted obtain by described Chinese medicine composition.
Third aspect present invention provides the preparation method of described Chinese medicine extract, detailed process is: each crude drug taking above-mentioned weight portion, mixing, be ground into 10-20 order coarse granule, the 5-7 that adds water is (volume namely added water is 5-7 times of coarse granule volume) doubly, decocts 2-4 time, collecting decoction, filter, it is 1.30-1.35 that filtrate is concentrated into relative density, obtained described Chinese medicine extract.Described relative density specifically refers to concentrated solution density relative to 4 DEG C of water 20 DEG C time.
Fourth aspect present invention provides described Chinese medicine composition, Chinese medicine extract to have sore throat in preparation treatment, purposes in hoarseness medicine.
Fifth aspect present invention provides a kind of Chinese medicine granules, is prepared by described Chinese medicine extract, and the raw material of described Chinese medicine granules comprises described Chinese medicine extract and adjuvant, and described adjuvant is lactose, mannitol, sodium benzoate.
Preferably, described Chinese medicine granules is the dried particles of described Chinese medicine extract, described Chinese medicine granules comprises adjuvant, wherein, the content of lactose is 0.01-0.25wt%, the content of mannitol is 0.03-0.75wt%, the content of sodium benzoate is 0.02-0.50wt%, and the weight ratio of described lactose, mannitol, sodium benzoate is 1:3:2.
Sixth aspect present invention provides the preparation method of described granule; lactose, mannitol, sodium benzoate is added as adjuvant in above-mentioned Chinese medicine extract; mixing; granulated by granulation machine; granule is dried 10-50min at 50-70 DEG C; drying to moisture in granule is 5-8wt%, obtains granule.
As mentioned above, the Chinese medicine composition of a kind of cleaning throat and moistening larynx of the present invention, have following beneficial effect: in Chinese medicine composition of the present invention, FRUCTUS TERMINALIAE IMMATURUS is the dry young fruit of Combretum Racemosum plant Fructus Chebulae TerminaliachebuZaRetz., relieving sore-throat by clearing away heat, promoting the production of body fluid wets one's whistle, and is monarch drug.
Radix Platycodonis (root of Campanulaceae Radix Platycodonis Platycodongrandiflorus (Jacq.) A.DC.) dispersing lung-QI and dissipating phlegm, Caulis Bambusae In Taenia (intermediate layer of grass bambusa breviflora Munro BambusatuldoidesMunro stem) removing heat from the lung and dissipating phlegm, Semen Sterculiae Lychnophorae (dry mature seed of Sterculiaceae plant Semen Sterculiae Lychnophorae SterculialychnophoraHance) moistening the lung and resolving phlegm, play lung qi dispersing sore-throat relieving altogether, sound producing treats mute merit; Exocarpium Citri Rubrum (outside rind of rutaceae orange CitrusreticulataBlanco and variety thereof) cold expelling dampness, activating QI to eliminate phlegm, alleviating distention in middle-JIAO stomach invigorating, Fructus Aurantii (the dry immature fruit of rutaceae Citrus aurantium Linn. CitrusaurantiumL. and variety thereof) regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.Rhizoma Cyperi (processed with vinegar) (Rhizoma Cyperi is the dry rhizome of sedge dried tuber CyperusrotundusL.) resolving depression of regulating the flow of vital energy, pain relieving regulating menstruation.Caulis Perillae (the dry stem of labiate Folium Perillae Perillafrutescens (L.) Britt.) regulating the flow of QI to ease the stomach, pain relieving.Lignum Aquilariae Resinatum (Isolated From Thymelaeaceae Species Lignum Aquilariae Resinatum Aquilariasinensis (Lour.) Gilg contains the timber of resin) promoting the circulation of QI to relieve pain, warming middle-JIAO to arrest vomiting, helping inspiration to relieve asthma.Be ministerial drug altogether, to strengthen monarch drug relieving sore-throat by clearing away heat, the merit that the chest stuffiness relieving wets one's whistle.
Folium Mori (dried leaves of moraceae plants Mulberry MorusalbaL.) dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving.Fructus Perillae (dry mature fruit of labiate Folium Perillae Perillafrutescens (L.) Britt.) lowering the adverse-rising QI to resolve phlegm, relieving cough and asthma, loosening bowel to relieve constipation.Auxiliary monarch drug dissipating phlegm and keeping the adverse QI downwards, dispelling wind and heat pathogens, resolving toxin and disinhibiting the throat is adjuvant drug altogether.
Mentholum extracted by the leaf of Herba Menthae and stem, white crystal, molecular formula C
10h
20o, No. CAS is 89-78-1, clear light cool loose, clear sharp laryngopharynx; Radix Panacis Quinquefolii (dry root of Araliaceae Radix Panacis Quinquefolii PanaxquinquefoliumL.) boosting qi and nourishing yin, clearing away heat and promoting production of body fluid; Fructus Momordicae (dry fruit of cucurbitaceous plant Fructus Momordicae MomordicagrosvenoriSwingle) clearing heat and moistening lung, laxation relieving constipation; Altogether for making medicine.
Above-mentioned all medicines share, and play relieving sore-throat by clearing away heat altogether, merit that the chest stuffiness relieving wets one's whistle.
The present invention eliminates this cold medicine of Radix Scutellariae; the consumption of reasonably combined each composition; sum up when the weight ratio of FRUCTUS TERMINALIAE IMMATURUS, Radix Platycodonis, Caulis Bambusae In Taenia, Semen Sterculiae Lychnophorae is 3:2:2:1 further; drug effect is remarkable, and compare the existing medicine that wets one's whistle, the side effect of Chinese medicine composition of the present invention to human body is little; evident in efficacy to pharyngeal dryness, hoarseness; do not injure one's stomach, can life-time service, to protect vocal cords.
When aforementioned pharmaceutical compositions is made granule, selecting of adjuvant is most important, and adopt lactose, mannitol, sodium benzoate as adjuvant in the present invention, lactose is as filler, stable in the air, not easily moisture absorption, does not have an effect with other compositions; Mannitol, contribute to the drying keeping granule, the dissolubility in water is good, and taste is sweet, contributes to the bitterness alleviating Chinese medicine ingredients; Sodium benzoate, pleasantly sweet, stable in the air, there are good antisepsis and hydrotropy effect, in the present invention mainly as antiseptic.The consumption of the reasonably combined above-mentioned each adjuvant of the present invention, the granule good stability made, dissolution velocity is fast, and human body easily absorbs, and the holding time is long, has good anti-microbial property, simultaneously the bitterness of effective alleviation Chinese medicine, and to having sore throat, hoarseness is evident in efficacy.
Detailed description of the invention
Below by way of specific instantiation, embodiments of the present invention are described, those skilled in the art the content disclosed by this description can understand other advantages of the present invention and effect easily.The present invention can also be implemented or be applied by detailed description of the invention different in addition, and the every details in this description also can based on different viewpoints and application, carries out various modification or change not deviating under spirit of the present invention.
Embodiment 1
A Chinese medicine composition for cleaning throat and moistening larynx, comprises the component of following weight portion:
FRUCTUS TERMINALIAE IMMATURUS 60 parts;
Radix Platycodonis 40 parts;
Caulis Bambusae In Taenia 40 parts;
Semen Sterculiae Lychnophorae 20 parts;
Exocarpium Citri Rubrum 30 parts;
Fructus Aurantii 25 parts;
15 parts, Folium Mori;
Rhizoma Cyperi (processed with vinegar) 20 parts;
Fructus Perillae 10 parts;
Caulis Perillae 8 parts;
Lignum Aquilariae Resinatum 20 parts;
Mentholum 5 parts;
Radix Panacis Quinquefolii 6 parts;
Fructus Momordicae 8 parts.
By the raw material blending of above-mentioned weight portion, be ground into 10 object coarse granules, add water 5 times; decoct 2 times, collecting decoction, filter; it is 1.30 that filtrate is concentrated into relative density; obtained Chinese medicine extraction liquid, adds lactose, mannitol, sodium benzoate as adjuvant in extracting solution, mixing; granulated by granulation machine; granule is dried 10min at 70 DEG C, and drying moisture to granule is 5wt%, obtained granule.In the granule that the present embodiment obtains, the content of lactose is 0.01wt%, the content of mannitol is 0.03wt%, the content of sodium benzoate is 0.02wt%.
Embodiment 2
A Chinese medicine composition for cleaning throat and moistening larynx, comprises the component of following weight portion:
FRUCTUS TERMINALIAE IMMATURUS 69 parts;
Radix Platycodonis 46 parts;
Caulis Bambusae In Taenia 46 parts;
Semen Sterculiae Lychnophorae 23 parts;
Exocarpium Citri Rubrum 35 parts;
Fructus Aurantii 30 parts;
20 parts, Folium Mori;
Rhizoma Cyperi (processed with vinegar) 25 parts;
Fructus Perillae 15 parts;
Caulis Perillae 10 parts;
Lignum Aquilariae Resinatum 22 parts;
Mentholum 7 parts;
Radix Panacis Quinquefolii 7 parts;
Fructus Momordicae 10 parts.
By the raw material blending of above-mentioned weight portion, be ground into 15 order coarse granules, add water 6 times; decoct 3 times, collecting decoction, filter; it is 1.32 that filtrate is concentrated into relative density; obtained Chinese medicine extraction liquid, adds lactose, mannitol, sodium benzoate as adjuvant in extracting solution, mixing; granulated by granulation machine; granule is dried 20min at 65 DEG C, and drying moisture to granule is 6wt%, obtained granule.In the granule that the present embodiment obtains, the content of lactose is 0.06wt%, the content of mannitol is 0.18wt%, the content of sodium benzoate is 0.12wt%.
Embodiment 3
A Chinese medicine composition for cleaning throat and moistening larynx, comprises the component of following weight portion:
FRUCTUS TERMINALIAE IMMATURUS 75 parts;
Radix Platycodonis 50 parts;
Caulis Bambusae In Taenia 50 parts;
Semen Sterculiae Lychnophorae 25 parts;
Exocarpium Citri Rubrum 37 parts;
Fructus Aurantii 33 parts;
23 parts, Folium Mori;
Rhizoma Cyperi (processed with vinegar) 30 parts;
Fructus Perillae 18 parts;
Caulis Perillae 12 parts;
Lignum Aquilariae Resinatum 25 parts;
Mentholum 8 parts;
Radix Panacis Quinquefolii 8 parts;
Fructus Momordicae 11 parts.
By the raw material blending of above-mentioned weight portion, be ground into 20 order coarse granules, add water 7 times; decoct 4 times, collecting decoction, filter; it is 1.33 that filtrate is concentrated into relative density; obtained Chinese medicine extraction liquid, adds lactose, mannitol, sodium benzoate as adjuvant in extracting solution, mixing; granulated by granulation machine; granule is dried 30min at 60 DEG C, and drying moisture to granule is 7wt%, obtained granule.In the granule that the present embodiment obtains, the content of lactose is 0.11wt%, the content of mannitol is 0.33wt%, the content of sodium benzoate is 0.22wt%.
Embodiment 4
A Chinese medicine composition for cleaning throat and moistening larynx, comprises the component of following weight portion:
FRUCTUS TERMINALIAE IMMATURUS 81 parts;
Radix Platycodonis 54 parts;
Caulis Bambusae In Taenia 54 parts;
Semen Sterculiae Lychnophorae 27 parts;
Exocarpium Citri Rubrum 40 parts;
Fructus Aurantii 35 parts;
25 parts, Folium Mori;
Rhizoma Cyperi (processed with vinegar) 35 parts;
Fructus Perillae 20 parts;
Caulis Perillae 13 parts;
Lignum Aquilariae Resinatum 26 parts;
Mentholum 9 parts;
Radix Panacis Quinquefolii 9 parts;
Fructus Momordicae 12 parts.
By the raw material blending of above-mentioned weight portion, be ground into 10 order coarse granules, add water 5 times; decoct 2 times, collecting decoction, filter; it is 1.34 that filtrate is concentrated into relative density; obtained Chinese medicine extraction liquid, adds lactose, mannitol, sodium benzoate as adjuvant in extracting solution, mixing; granulated by granulation machine; granule is dried 40min at 55 DEG C, and drying moisture to granule is 8wt%, obtained granule.In the granule that the present embodiment obtains, the content of lactose is 0.16wt%, the content of mannitol is 0.48wt%, the content of sodium benzoate is 0.32wt%.
Embodiment 5
A Chinese medicine composition for cleaning throat and moistening larynx, comprises the component of following weight portion:
FRUCTUS TERMINALIAE IMMATURUS 90 parts;
Radix Platycodonis 60 parts;
Caulis Bambusae In Taenia 60 parts;
Semen Sterculiae Lychnophorae 30 parts;
Exocarpium Citri Rubrum 45 parts;
Fructus Aurantii 40 parts;
30 parts, Folium Mori;
Rhizoma Cyperi (processed with vinegar) 40 parts;
Fructus Perillae 25 parts;
Caulis Perillae 15 parts;
Lignum Aquilariae Resinatum 30 parts;
Mentholum 10 parts;
Radix Panacis Quinquefolii 11 parts;
Fructus Momordicae 12 parts.
By the raw material blending of above-mentioned weight portion, be ground into 15 order coarse granules, add water 6 times; decoct 3 times, collecting decoction, filter; it is 1.35 that filtrate is concentrated into relative density; obtained Chinese medicine extraction liquid, adds lactose, mannitol, sodium benzoate as adjuvant in extracting solution, mixing; granulated by granulation machine; granule is dried 50min at 50 DEG C, and drying moisture to granule is 5wt%, obtained granule.In the granule that the present embodiment obtains, the content of lactose is 0.25wt%, the content of mannitol is 0.75wt%, the content of sodium benzoate is 0.50wt%.
Side effect contrast experiment
The granule obtained by above-described embodiment 1-5, by each serving with 4g, morning, noon and afternoon every day three times, treats 70 pharyngeal drynesses, hoarseness person.Matched group adopts the existing throat-benefiting granule (manufacturer: Lerentang Pharmaceutical Factory, Zhongxin Pharmaceutical Group Co., Ltd., Tianj containing Radix Scutellariae, the accurate word Z12020452 of traditional Chinese medicines), by each serving with 4g, morning, noon and afternoon every day three times, other 70 pharyngeal drynesses, hoarseness person are treated.To each case, an every three days statistics symptom variation situation, observed result is as follows: in 70 cases of the Granules in Treating that embodiment 1-5 obtains, sense of having sore throat fades away, and does not all occur side effect phenomenon after 3 days, 6 days, 9 days; In 70 cases of control sample treatment, sense of having sore throat fades away, and has 1 case to occur that stomach is not felt very well after 3 days, has 3 cases to occur that stomach is not felt very well after 6 days, 6 cases are had to occur the situation of stomach discomfort after 9 days, the formulation differences of experimental group and matched group is mainly Radix Scutellariae, visible, the matched group containing Radix Scutellariae, namely existing throat-benefiting granule is applicable to the treatment of short-term, but be unsuitable for life-time service, especially for old man and child, the effect of injuring one's stomach is more obvious.The present composition overcomes this defect, and toxic and side effects is little, does not injure one's stomach, can life-time service to protect vocal cords.
Treat clinical effectiveness experiment of having sore throat
1. physical data
Use the traditional Chinese medicine composition for treating of cleaning throat and moistening larynx of the present invention to have sore throat the routine observation of curative effect of patient 95, oldest 76 years old, what the age was minimum was 16 years old.
2. Therapeutic Method
The granule that Example 1-5 is obtained, oral, by each serving with 4g, morning, noon and afternoon every day three times, warm water takes, and treats pharyngeal dryness, hoarseness person.Within every three days, once add up.
3. the results are shown in Table 1:
Table 1
| Recovery from illness | Effectively | Invalid |
| After 3 days | 43 | 35 | 17 |
| After 6 days | 55 | 23 | 17 |
| After 9 days | 57 | 22 | 16 |
Recovery from illness refers to that symptom all disappears, and effectively refers to that symptom alleviates, and invalid finger symptom is rear without significant change before the treatment.As shown in table 1,95 examples are had sore throat in patient, 43 example recoveries from illness after 3 days, and effectively, 17 examples are without positive effect for 35 examples; After 6 days, 95 examples are had sore throat 55 example recoveries from illness in patient, and effectively, 17 examples are still without positive effect for 23 examples; After 9 days, all types of case loads changes not quite compared with the situation after 6 days, 57 example recoveries from illness, and effectively, 16 examples are without positive effect for 22 examples.As can be seen from the data of table 1, the present invention treats the patient that has sore throat, and after 6 days, total effective rate reaches 82.1%, and after 9 days, total effective rate reaches 83.1%.
Melting is tested
The Chinese medicinal composition granules 10g of the present invention that Example 1-5 is obtained respectively, heating water (70-80 DEG C) 200mL, stir, and record each sample dissolves the required time completely.
Control sample 1: the lactose in embodiment 1 adjuvant is removed, retain mannitol and sodium benzoate, total consumption of adjuvant is identical with embodiment 1, adopt the preparation method identical with embodiment 1 to obtain granule, in obtained granule, the content of mannitol is 0.036wt%, the content of sodium benzoate is 0.024wt%.Get this granule 10g, heating water (70-80 DEG C) 200mL, stir, record each sample dissolves the required time completely.
Control sample 2: the mannitol in embodiment 1 adjuvant is removed, retain lactose and sodium benzoate, total consumption of adjuvant is identical with embodiment 1, adopt the preparation method identical with embodiment 1 to obtain granule, in obtained granule, the content of lactose is 0.02wt%, the content of sodium benzoate is 0.04wt%.Get this granule 10g, heating water (70-80 DEG C) 200mL, stir, record each sample dissolves the required time completely.
Control sample 3: the sodium benzoate in embodiment 1 adjuvant is removed, retain lactose and mannitol, total consumption of adjuvant is identical with embodiment 1, adopt the preparation method identical with embodiment 1 to obtain granule, in obtained granule, the content of lactose is 0.015wt%, the content of mannitol is 0.045wt%.Get this granule 10g, heating water (70-80 DEG C) 200mL, stir, record each sample dissolves the required time completely.
Control sample 4: the weight ratio of lactose, mannitol, sodium benzoate in embodiment 1 adjuvant is adjusted to 1:3:1, total consumption of adjuvant is identical with embodiment 1, adopt the preparation method identical with embodiment 1 to obtain granule, in obtained granule, the content of lactose is 0.012wt%, the content of mannitol is 0.036wt%, the content of sodium benzoate is 0.012wt%.Get this granule 10g, heating water (70-80 DEG C) 200mL, stir, record each sample dissolves the required time completely.
Control sample 5: the weight ratio of lactose, mannitol, sodium benzoate in embodiment 1 adjuvant is adjusted to 1:3:3, total consumption of adjuvant is identical with embodiment 1, adopt the preparation method identical with embodiment 1 to obtain granule, in obtained granule, the content of lactose is 0.00857wt%, the content of mannitol is 0.02571wt%, the content of sodium benzoate is 0.02571wt%.Get this granule 10g, heating water (70-80 DEG C) 200mL, stir, record each sample dissolves the required time completely.
Control sample 6: the weight ratio of lactose, mannitol, sodium benzoate in embodiment 1 adjuvant is adjusted to 1:2:2, total consumption of adjuvant is identical with embodiment 1, adopt the preparation method identical with embodiment 1 to obtain granule, in obtained granule, the content of lactose is 0.012wt%, the content of mannitol is 0.024wt%, the content of sodium benzoate is 0.024wt%.Get this granule 10g, heating water (70-80 DEG C) 200mL, stir, record each sample dissolves the required time completely.
Control sample 7: the weight ratio of lactose, mannitol, sodium benzoate in embodiment 1 adjuvant is adjusted to 1:4:2, total consumption of adjuvant is identical with embodiment 1, adopt the preparation method identical with embodiment 1 to obtain granule, in obtained granule, the content of lactose is 0.00857wt%, the content of mannitol is 0.03428wt%, the content of sodium benzoate is 0.01714wt%.Get this granule 10g, heating water (70-80 DEG C) 200mL, stir, record each sample dissolves the required time completely.
Melting experimental result:
Table 2
The present invention has carried out a large amount of experiments to the consumption of three kinds of adjuvants, attempt multiple consumption proportion, from upper table 2, when lactose: mannitol: time sodium benzoate=1:3:2 (weight ratio), the favorable solubility of granule of the present invention, dissolve required time completely at 2.5-3min, taking convenience, when adjuvant adopts other weight ratios, granule dissolves required time completely all at more than 4min, all cannot reach lower complete solution time, patient is caused to take inconvenience, need to wait for that the long period just can take, granule dissolves that required time is longer also can cause the absorption of human body slower completely, affect the performance of drug effect, and then cause therapeutic effect not good.
The checking of analytical method
Repeated experiment: the granule 0.5g taking embodiment 1-5 respectively, each embodiment respectively gets 5 parts, with 50% dissolve with ethanol solution of 30mL, precision measures 1mL subsequent filtrate and is placed in 50mL volumetric flask, 50% ethanol is settled to scale, it can be used as need testing solution, and the alcoholic solution using 50% is as blank, at maximum wavelength place, (280nm) measures light absorption value, and calculates RSD value.Statistics is as following table:
Table 3 repeated experiment statistical table
Conclusion: according to the result of upper table 3, RSD value remains on 0.205%-0.235%, illustrates that the repeatability of granule of the present invention is good.
Precision Experiment: the granule 0.5g taking embodiment 1-5 respectively, with 50% dissolve with ethanol solution of 30mL, precision measures 1mL subsequent filtrate and is placed in 50mL volumetric flask, and 50% ethanol is settled to scale, it can be used as need testing solution.Repeat sample introduction 5 times, at maximum wavelength place, (280nm) measures light absorption value, and calculates RSD value.
Table 4 Precision Experiment statistical table
Conclusion: from upper table 4, RSD value remains on 0.180%-0.235%, illustrates that the elaboration of granule of the present invention is good.
Above-described embodiment is illustrative principle of the present invention and effect thereof only, but not for limiting the present invention.Any person skilled in the art scholar all without prejudice under spirit of the present invention and category, can modify above-described embodiment or changes.Therefore, such as have in art usually know the knowledgeable do not depart from complete under disclosed spirit and technological thought all equivalence modify or change, must be contained by claim of the present invention.
Claims (10)
1. a Chinese medicine composition for cleaning throat and moistening larynx, comprises the component of following weight portion:
FRUCTUS TERMINALIAE IMMATURUS 60-90 part;
Radix Platycodonis 40-60 part;
Caulis Bambusae In Taenia 40-60 part;
Semen Sterculiae Lychnophorae 20-30 part;
Exocarpium Citri Rubrum 30-45 part;
Fructus Aurantii 25-40 part;
Folium Mori 15-30 part;
Rhizoma Cyperi (processed with vinegar) 20-40 part;
Fructus Perillae 10-25 part;
Caulis Perillae 8-15 part;
Lignum Aquilariae Resinatum 20-30 part;
Mentholum 5-10 part;
Radix Panacis Quinquefolii 6-11 part;
Fructus Momordicae 8-12 part.
2. Chinese medicine composition according to claim 1, is characterized in that, described FRUCTUS TERMINALIAE IMMATURUS: Radix Platycodonis: Caulis Bambusae In Taenia: Semen Sterculiae Lychnophorae=3:2:2:1, and described ratio is weight ratio.
3. Chinese medicine composition according to claim 1, is characterized in that, comprises the component of following weight portion:
FRUCTUS TERMINALIAE IMMATURUS 69-81 part;
Radix Platycodonis 46-54 part;
Caulis Bambusae In Taenia 46-54 part;
Semen Sterculiae Lychnophorae 23-27 part;
Exocarpium Citri Rubrum 35-40 part;
Fructus Aurantii 30-35 part;
Folium Mori 20-25 part;
Rhizoma Cyperi (processed with vinegar) 25-35 part;
Fructus Perillae 15-20 part;
Caulis Perillae 10-13 part;
Lignum Aquilariae Resinatum 22-26 part;
Mentholum 7-9 part;
Radix Panacis Quinquefolii 6-9 part;
Fructus Momordicae 10-12 part.
4. Chinese medicine composition according to claim 3, is characterized in that, comprises the component of following weight portion:
FRUCTUS TERMINALIAE IMMATURUS 75 parts;
Radix Platycodonis 50 parts;
Caulis Bambusae In Taenia 50 parts;
Semen Sterculiae Lychnophorae 25 parts;
Exocarpium Citri Rubrum 37 parts;
Fructus Aurantii 33 parts;
23 parts, Folium Mori;
Rhizoma Cyperi (processed with vinegar) 30 parts;
Fructus Perillae 18 parts;
Caulis Perillae 12 parts;
Lignum Aquilariae Resinatum 25 parts;
Mentholum 8 parts;
Radix Panacis Quinquefolii 8 parts;
Fructus Momordicae 11 parts.
5. a Chinese medicine extract, is extracted by the Chinese medicine composition described in any one of claim 1-4 and obtains.
6. the preparation method of a Chinese medicine extract as claimed in claim 5, detailed process is: each crude drug taking above-mentioned weight portion, mixing, be ground into 10-20 order coarse granule, the 5-7 that adds water doubly, decocts 2-4 time, collecting decoction, filter, it is 1.30-1.35 that filtrate is concentrated into relative density, obtained described Chinese medicine extract.
7. the Chinese medicine composition as described in any one of claim 1-4, Chinese medicine extract as claimed in claim 5 are had sore throat in preparation treatment, purposes in hoarseness medicine.
8. a Chinese medicine granules, is prepared by Chinese medicine extract according to claim 5, and the raw material of described Chinese medicine granules comprises described Chinese medicine extract and adjuvant, and described adjuvant is lactose, mannitol, sodium benzoate.
9. granule according to claim 8, it is characterized in that, described Chinese medicine granules is the dried particles of described Chinese medicine extract, described Chinese medicine granules comprises adjuvant, wherein, the content of lactose is 0.01-0.25wt%, the content of mannitol is 0.03-0.75wt%, the content of sodium benzoate is 0.02-0.50wt, and the weight ratio of described lactose, mannitol, sodium benzoate is 1:3:2.
10. the preparation method of a granule as claimed in claim 8 or 9, detailed process is: in described Chinese medicine extract, add lactose, mannitol, sodium benzoate as adjuvant, mixing, granulate, granule is dried 10-50min at 50-70 DEG C, drying to moisture in granule is 5-8wt%, obtains granule.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101095736A (en) * | 2006-06-28 | 2008-01-02 | 厦门桂龙投资管理有限公司 | Chinese traditional medicine composition for treating acute and chronic pharyngitis, tonsillitis and method of making the same |
| JP2012107002A (en) * | 2010-10-27 | 2012-06-07 | Yakult Honsha Co Ltd | Stress reliever |
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2015
- 2015-10-15 CN CN201510665530.2A patent/CN105148089A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101095736A (en) * | 2006-06-28 | 2008-01-02 | 厦门桂龙投资管理有限公司 | Chinese traditional medicine composition for treating acute and chronic pharyngitis, tonsillitis and method of making the same |
| JP2012107002A (en) * | 2010-10-27 | 2012-06-07 | Yakult Honsha Co Ltd | Stress reliever |
Non-Patent Citations (2)
| Title |
|---|
| 吕怀刚等: "微波加清喉利咽颗粒治疗慢性肥厚性咽炎", 《中国医药导报》 * |
| 张淳理等: "《增强免疫力食物与食疗方》", 31 October 2013, 金盾出版社 * |
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