CN105147878A - Lavender essential oil composition and preparation method thereof - Google Patents
Lavender essential oil composition and preparation method thereof Download PDFInfo
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- CN105147878A CN105147878A CN201510117282.8A CN201510117282A CN105147878A CN 105147878 A CN105147878 A CN 105147878A CN 201510117282 A CN201510117282 A CN 201510117282A CN 105147878 A CN105147878 A CN 105147878A
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- herba lysimachiae
- quintessence oil
- lysimachiae foenum
- graeci quintessence
- vitis viniferae
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Abstract
The invention provides a use of a composition of lavender essential oil and grape seed extract in preparation of antioxidation health products or drugs. The invention also provides an antioxidation health or pharmaceutical composition. The antioxidation health or pharmaceutical composition comprises, by weight, 15-20 parts of lavender essential oil, 30-35 parts of grape seed extract and 1-3 parts of an anti-oxidant. The invention also provides a preparation method and a use of the pharmaceutical composition. The antioxidation health or pharmaceutical composition can realize essential oil oral administration. Through combination of the grape seed extract and lavender essential oil, a cell active oxygen removal capability is improved and cooperative synergism is improved.
Description
Technical field
The present invention relates to a kind of Herba Lysimachiae foenum-graeci quintessence oil compositions, relate to health product or medicine field.
Background technology
Herba Lysimachiae foenum-graeci quintessence oil is refined by lavandula angustifolia to form, can heat-clearing and toxic substances removing, cleaning skin, control oil content, freckle removing and whitening, wrinkle removal skin care, eye haustra-dsipelling black eye, also can promote that damaged tissues regenerates the skin-protecting functions such as recovery, it can purify, pacify soul, alleviate indignation and used-up sensation, make people can even-tempered and good-humouredly in the face of live.There is sedation effect to heart, hypertension can be reduced, pacify cardiopalmus, helpful for insomnia.
At present about the document of Herba Lysimachiae foenum-graeci quintessence oil and patent report more, as: application number: 201310552557.1, denomination of invention: Lavender compound essential oil, the invention discloses a kind of Lavender compound essential oil, comprise following weight parts raw material: Herba Lysimachiae foenum-graeci quintessence oil 50 parts, rosemary ethereal oil 10-30 part, Semen pruni armeniacae oil 30-50 part, Oleum Vitis viniferae 10-30 part.Lavender compound essential oil of the present invention, can heat-clearing and toxic substances removing, cleaning skin, controls oil content, freckle removing and whitening, wrinkle removal skin care, eye haustra-dsipelling black eye, also can promote that damaged tissues regenerates skin-protecting function such as recoverys grade.Application number: 201110367865.8, denomination of invention: a kind of compound essential-oil sleep-helpful capsule comprises Herba Lysimachiae foenum-graeci quintessence oil, Oleum Vitis viniferae, vitamin E, propolis, vitamin B1, Semen Tritici aestivi germ oil, dextrin, each component and content (in weight fraction) thereof are: Herba Lysimachiae foenum-graeci quintessence oil: 0.2-1.0 part; Oleum Vitis viniferae: 0.5-2.0 part; Vitamin E: 1.5-3.5 part; Propolis: 20-30 part; Vitamin B1: 0.5-1.0 part; Semen Tritici aestivi germ oil: 1-5 part, dextrin: 60-80 part.This compound essential-oil sleep-helpful capsule is primary raw material with Herba Lysimachiae foenum-graeci quintessence oil and propolis, has effect of calming soporific.Application number: 201110143869.8, denomination of invention: a kind of can the compound agilawood essential oil of improving water flood, relate to a kind of can the compound agilawood essential oil of improving water flood, be made up through mix homogeneously of agilawood essential oil, Herba Lysimachiae foenum-graeci quintessence oil, chamomile essential oil and Oleum Vitis viniferae.Natural plant extracts is carried out scientific compatibility by the present invention, effectively improves sleep quality, increases the length of one's sleep.Application number: 201310226786.4, denomination of invention: a kind of Sun-proof perfume, the invention provides a kind of Sun-proof perfume, be made up of the raw material of following mass percent: citric acid 3-5%, jasmine flower essence 10-17%, Herba Lysimachiae foenum-graeci quintessence oil 3-6%, Semen Vitis viniferae extract 7-30%, propylene glycol 6-8%, Sorbitol 1-3%, all the other are 95% ethanol.Add Semen Vitis viniferae extract in perfume and have good ultraviolet (UV) A barriering effect, can effectively prevent melanic generation, available protecting skin, from sunburn, has soothing effect simultaneously.
At present, there is no and Herba Lysimachiae foenum-graeci quintessence oil and Semen Vitis viniferae extract compatibility are used for antioxidative pertinent literature report.
Summary of the invention
The invention provides the novelty teabag of a kind of Herba Lysimachiae foenum-graeci quintessence oil and Semen Vitis viniferae extract conbined usage.Another technical scheme of the present invention there is provided a kind of compositions containing Herba Lysimachiae foenum-graeci quintessence oil.Present invention also offers preparation method and the purposes of said composition.
The invention provides Herba Lysimachiae foenum-graeci quintessence oil and Semen Vitis viniferae extract conbined usage is preparing the purposes in oxidation-resisting health-care product or medicine.
Wherein, described Herba Lysimachiae foenum-graeci quintessence oil and the weight proportion of Semen Vitis viniferae extract are:
Herba Lysimachiae foenum-graeci quintessence oil 15-20 part, Semen Vitis viniferae extract 30-35 part.
Wherein, described Herba Lysimachiae foenum-graeci quintessence oil and the weight proportion of Semen Vitis viniferae extract are:
Herba Lysimachiae foenum-graeci quintessence oil 16.5 parts, Semen Vitis viniferae extract 33 parts.
Wherein, No. CAS of described Herba Lysimachiae foenum-graeci quintessence oil is: 8000-28-0; No. CAS of described Semen Vitis viniferae extract is 84929-27-1.
The invention provides a kind of compositions, it is made up of the raw material of following weight proportioning:
Herba Lysimachiae foenum-graeci quintessence oil 15-20 part, Semen Vitis viniferae extract 30-35 part, vitamin e1-3 parts.
Further preferably, it is made up of the raw material of following weight proportioning:
Herba Lysimachiae foenum-graeci quintessence oil 16.5 parts, Semen Vitis viniferae extract 33 parts, antioxidant vitamin E2 part.
Medicine of the present invention is active component by Herba Lysimachiae foenum-graeci quintessence oil, Semen Vitis viniferae extract, vitamin E, adds acceptable adjuvant or complementary composition in food or health food or medicine and be prepared into conventional preparation.
Wherein, described preparation is oral formulations.
Wherein, described preparation is tablet, capsule, pill, oral liquid, granule.
The invention provides a kind of method preparing described compositions, it comprises the steps:
A, get the raw material of each weight proportion;
B, former medicine and adjuvant to be sieved; Take Herba Lysimachiae foenum-graeci quintessence oil in proportion, the clathrate prepared with beta-cyclodextrin inclusion compound, Semen Vitis viniferae extract, vitamin E add filler mix homogeneously, then add binding agent soft material, sieve granulation, wet granular is dry again, crosses 20 mesh sieve granulate, add lubricant, the mixing of additional disintegrating agent, tabletting.
Wherein, the filler described in b step is starch, and binding agent is 70% ethanol, and lubricant is magnesium stearate, and disintegrating agent is carboxymethyl starch sodium.
Present invention also offers described compositions and prepare the purposes in oxidation-resisting health-care product or medicine.
Health product of the present invention can realize quintessence oil oralization, and after Semen Vitis viniferae extract associating Oleum lavandula angustifolia, cytoactive oxygen scavenging capacity has reinforced effects, has the effect of Synergistic.
Accompanying drawing explanation
Fig. 1 beta-schardinger dextrin-microgram
Herba Lysimachiae foenum-graeci quintessence oil microgram after Fig. 2 enclose
Herba Lysimachiae foenum-graeci quintessence oil GC-MS chromatogram (before and after enclose is described, Herba Lysimachiae foenum-graeci quintessence oil composition does not change) before and after Fig. 3 enclose
Fig. 4 Herba Lysimachiae foenum-graeci quintessence oil MTT curve chart
Fig. 5 Semen Vitis viniferae extract MTT curve chart
Fig. 6 fluidic cell figure
Fig. 7 interpretation of result figure
Detailed description of the invention
The preparation of embodiment 1 Tablets
Weighed beta-schardinger dextrin-16g, is placed in tool plug triangular pyramidal bottle, and the 458ml that adds water heating makes it to dissolve completely, under being down to constant temperature 40 DEG C stirring, being slowly added drop-wise in cyclodextrin solution with syringe after Garden lavender quintessence oil 2mg and dehydrated alcohol 2mg is diluted, jumping a queue, continue to stir after 1.5h, put cold preservation 12h at 4 DEG C, refrigerator, then after rapid filtration under suction, first rinse with a small amount of water, repeatedly wash on a small quantity with the petroleum ether of 30-60 DEG C again, drain, 40 DEG C of dry 6h, weigh 12.94g, obtains Oleum lavandula angustifolia clathrate.
Again in proportion weighed Herba Lysimachiae foenum-graeci quintessence oil clathrate 13g, Semen Vitis viniferae extract 20g (response rate of Herba Lysimachiae foenum-graeci quintessence oil clathrate is 75.44%, Herba Lysimachiae foenum-graeci quintessence oil amount is wherein about 10g), vitamin E2 g, add starch 30g again, be wetting agent with 70% ethanol, wet granulation, crosses No. two sieves, dry, granulate, adds carboxymethyl starch sodium 2g and magnesium stearate 1g, tabletting and get final product.Every sheet 300mg.
Wherein, instructions of taking is two panels every day, takes 600mg altogether, and wherein every consumption per day of Herba Lysimachiae foenum-graeci quintessence oil is 100mg, every consumption per day of Semen Vitis viniferae extract is 200mg.
The preparation of embodiment 2 Herba Lysimachiae foenum-graeci quintessence oil clathrate of the present invention
1, the ratio research of beta-schardinger dextrin-and Herba Lysimachiae foenum-graeci quintessence oil
Ratio is respectively 2:1, and when 4:1,6:1,8:1,10:1,12:1, saturation time is 1.5h, and saturation temperature is 40 DEG C, and dehydrated alcohol and Herba Lysimachiae foenum-graeci quintessence oil ratio are 1:2, are preferably 8:1.
2, the research of enclose time
The enclose time is respectively 0.5h, and when 1h, 1.5h, 2h, 2.5h, 3h, β-CD and Herba Lysimachiae foenum-graeci quintessence oil ratio are 8:1, and enclose temperature is 40 DEG C, and dehydrated alcohol and Herba Lysimachiae foenum-graeci quintessence oil ratio are 1:2, are preferably 1.5h.
3, the research of enclose temperature
Enclose temperature is respectively 30 DEG C, 35 DEG C, 40 DEG C, 45 DEG C, 50 DEG C, and when 55 DEG C, β-CD and Herba Lysimachiae foenum-graeci quintessence oil ratio are 8:1, and the enclose time is 1.5h, and dehydrated alcohol and Herba Lysimachiae foenum-graeci quintessence oil ratio are 1:2, are preferably 40 DEG C.
4, the ratio research of dehydrated alcohol and Herba Lysimachiae foenum-graeci quintessence oil
Ratio is respectively 0:1, and when 1:1,2:1,3:1,4:1,5:1, β-CD and Herba Lysimachiae foenum-graeci quintessence oil ratio are 8:1, and the enclose time is 1.5h, and enclose temperature is 40 DEG C, is preferably 1:1.
5, Orthogonal Experiment and Design, in table 1.
Last synthesis result is, beta-schardinger dextrin-and Herba Lysimachiae foenum-graeci quintessence oil ratio 8:1, enclose time 2 h, and enclose temperature is 40 degrees Celsius, and dehydrated alcohol and Herba Lysimachiae foenum-graeci quintessence oil ratio are 1:1.
6, the standard test of Herba Lysimachiae foenum-graeci quintessence oil clathrate
The investigation of 6.1 volatile oil utilization rates
By dry for gained clathrate precise weighing, put and be equipped with in zeolite 250ml round-bottomed flask, adding distil water 200m1, extract when volatile oil to oil mass no longer increases and stop heating, reading, must reclaim volatile oil volume, then is calculated as follows clathrate productive rate and volatile oil utilization rate.
Volatile oil utilization rate=[collection volatilization oil mass (ml)/add volatilization oil mass (ml)] × 100%
Clathrate productive rate={ clathrate weight (g)/[beta-schardinger dextrin-weight (g)+throwing oil mass (g)] } × 100%
End product is, the blank response rate of Oleum lavandula angustifolia clathrate is 75.44%, and clathrate productive rate is 80.67%.
6.2 microscopic examination
Blank clathrate is the translucent plate crystal of rule, Herba Lysimachiae foenum-graeci quintessence oil-beta-CD inclusion is unformed irregular powder, illustrate that the thing phase morphology before and after β-cdinclusion there occurs larger change, Oleum lavandula angustifolia enclose enters in material by beta-schardinger dextrin-, demonstrates the formation of clathrate.(see Fig. 1, Fig. 2)
Oleum lavandula angustifolia GC-MS chromatogram (see Fig. 3) before and after 6.3 enclose
Detection method articles of reference: the .GC-MS methods such as Yuan Suning, Du Weijun, Liu Cong measure the content [J] of linalool and linalyl acetate in separate sources lavenderessential oil. Xinjiang Medicine University's journal, 2012,11 (35): 1478-1482.
The investigation of 7 moulding processs
7.1 carry out different ratio research according to effective ingredient Herba Lysimachiae foenum-graeci quintessence oil 16.5 parts, Semen Vitis viniferae extract 33 parts, antioxidant vitamin E2 part and adjuvant, and the ratio of choosing is table 2.
Beneficial effect of the present invention is proved below by way of concrete pharmacodynamics test.
Material and reagent:
Mouse embryo fibroblast MEF cell; Oleum lavandula angustifolia relative density (20 DEG C/20 DEG C) 0.8875 is light yellow clear motile liquid; Grape Seed Extract Procyanidin, mass fraction 98.95% is chocolate brown powder; No. CAS of described Herba Lysimachiae foenum-graeci quintessence oil is: 8000-28-0; The CAS of described Semen Vitis viniferae extract (or claiming Grape Seed Extract Procyanidin) is 84929-27-1.
Thiazolyl blue MTT test kit; Active oxygen inspection test probe (DCFH-DA); DMEM (high sugar) culture medium; Active oxygen inhibitor NAC.
Test example 1 present composition cell MTT tests
Mice Inoculated fibroblast is (6000/ hole) in 96 orifice plates, after cell is completely adherent, get Concentraton gradient is (0, 0.1, 1, 10, 50, 100mg/ml) Oleum lavandula angustifolia and Grape Seed Extract Procyanidin do agent-feeding treatment, 40 μ LMTT solution (5mg/ml are added after 48 hours, i.e. 1%MTT) hatch 4h, after fully forming first a ceremonial jade-ladle, used in libation, extinction culture medium adds 150ul dimethyl sulfoxide and fully dissolves first a ceremonial jade-ladle, used in libation, microplate reader is adopted to detect OD value, recording Oleum lavandula angustifolia ic50 is 119.85, almost non-toxic property, Grape Seed Extract Procyanidin ic50 is 58.53, toxicity is very little.Result of the test in table 3, Fig. 4, Fig. 5.
Test example 2 the present invention combines cytoactive oxygen detection experiment
Another Mice Inoculated embryo fibroblast MEF cell (adopts every hole 10000) in 6 orifice plates, and whether after 24 hours, in inverted microscope, observe observation of cell state adherent.Cell state well adds H
2o
220 μMs and the Oleum lavandula angustifolia (LAO) that adds variable concentrations respectively and Grape Seed Extract Procyanidin (OPC) and its compatibility mixture, detect reactive oxygen species (ROS) situation of change (hydrogen peroxide can bring oxidative damage).Before collecting cell, 20min adds DCFH-DA probe (DCFH-DA work also concentration be 10-20 μM), after 20min, wash culture medium off, PBS rinses 3 times, centrifugally after trypsinization collect cell (centrifugal rotational speed is no more than 3000 turns), the centrifugal cell got off adopts and stops digestion containing the process of 10%GibcoDMEM serum, centrifugal rear employing PBS transfers in streaming pipe, setting flow cytometer, upper machine testing (adopting ssarea and fsarea to carry out detection cell during upper machine setting), is analyzed by FL1 passage.Two hydrogen-acetoacetic acid dichlorofluorescein (DCFH-DA) is selected to detect ROS's in cell, observe with Oleum lavandula angustifolia 5mg/ml and Grape Seed Extract Procyanidin 10mg/ml proportion compatibility that (content of Oleum lavandula angustifolia and the former florigen element of Semen Vitis viniferae is phalangeal cell consumption for effect during 1:2 is better herein, human body consumption is exactly that corresponding multiple increases, proportion compatibility is weight ratio), in upper machine testing cell line, ROS clearance rate is higher than two kinds of independent effects.
Illustrated by fluidic cell figure (Fig. 6) and interpretation of result figure (Fig. 7):
1, hydrogen peroxide has obvious active oxygen to raise after process mouse embryo cell mef cell;
2, the ROS that NAC can obviously suppress hydrogen peroxide to bring as active oxygen inhibitor raises phenomenon;
3, OPC and LAO processes in the independent situation of 10mg/ml and 5mg/ml does not affect mef cell;
4, LAO and OPC can the rising of part inhibit activities oxygen, and wherein OPC effect has significance;
5, OPC and LAO coprocessing obviously can reduce the ROS that hydrogen peroxide brings, and has significance.
Result of the test shows, orally uses, has significant reinforced effects to cytoactive oxygen scavenging capacity, have the effect of Synergistic by Grape Seed Extract Procyanidin is combined Oleum lavandula angustifolia.
Claims (10)
1. Herba Lysimachiae foenum-graeci quintessence oil and Semen Vitis viniferae extract conbined usage are preparing the purposes in oxidation-resisting health-care product or medicine.
2. purposes according to claim 1, is characterized in that: described Herba Lysimachiae foenum-graeci quintessence oil and the weight proportion of Semen Vitis viniferae extract are:
Herba Lysimachiae foenum-graeci quintessence oil 15-20 part, Semen Vitis viniferae extract 30-35 part.
3. purposes according to claim 2, is characterized in that: described Herba Lysimachiae foenum-graeci quintessence oil and the weight proportion of Semen Vitis viniferae extract are:
Herba Lysimachiae foenum-graeci quintessence oil 16.5 parts, Semen Vitis viniferae extract 33 parts.
4. the health care of antioxidation or a pharmaceutical composition, is characterized in that: it is made up of the raw material of following weight proportioning:
Herba Lysimachiae foenum-graeci quintessence oil 15-20 part, Semen Vitis viniferae extract 30-35 part, antioxidant 1-3 part.
5. compositions according to claim 4, is characterized in that: described antioxidant amounting vitamin E; It is made up of the raw material of following weight proportioning:
Herba Lysimachiae foenum-graeci quintessence oil 16.5 parts, Semen Vitis viniferae extract 33 parts, vitamin E2 part.
6. the compositions according to claim 4 or 5, is characterized in that: it is the preparation that main component is prepared from by Herba Lysimachiae foenum-graeci quintessence oil, Semen Vitis viniferae extract, vitamin E.
7. compositions according to claim 6, is characterized in that: described preparation is oral formulations.
8. compositions according to claim 7, is characterized in that: described preparation is tablet, capsule, pill, oral liquid, granule.
9. prepare a method for the compositions described in claim 4-8 any one, it is characterized in that: it comprises the steps:
A, get the raw material of each weight proportion;
B, former medicine and adjuvant to be sieved; Take Herba Lysimachiae foenum-graeci quintessence oil in proportion, the clathrate prepared with beta-cyclodextrin inclusion compound, Semen Vitis viniferae extract, vitamin E add filler mix homogeneously, then add binding agent soft material, sieve granulation, wet granular is dry again, crosses 20 mesh sieve granulate, add lubricant, the mixing of additional disintegrating agent, tabletting.
10. preparation method according to claim 9, is characterized in that: the filler described in b step is starch, and binding agent is 70% ethanol, and disintegrating agent is magnesium stearate.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107158358A (en) * | 2017-07-10 | 2017-09-15 | 东北林业大学 | A kind of anti-trick rhagadia cream of hazelnut oil and preparation method thereof |
| CN109566875A (en) * | 2018-12-07 | 2019-04-05 | 福建农业职业技术学院 | A kind of coating technique of Lavender |
| CN112451506A (en) * | 2020-12-10 | 2021-03-09 | 上海纳米技术及应用国家工程研究中心有限公司 | Preparation method of essential oil sustained-release capsule |
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| CN101953822A (en) * | 2010-07-30 | 2011-01-26 | 合肥立方制药有限公司 | Venlafaxine hydrochloride controlled release tablets and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107158358A (en) * | 2017-07-10 | 2017-09-15 | 东北林业大学 | A kind of anti-trick rhagadia cream of hazelnut oil and preparation method thereof |
| CN109566875A (en) * | 2018-12-07 | 2019-04-05 | 福建农业职业技术学院 | A kind of coating technique of Lavender |
| CN112451506A (en) * | 2020-12-10 | 2021-03-09 | 上海纳米技术及应用国家工程研究中心有限公司 | Preparation method of essential oil sustained-release capsule |
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