CN105142597A - Toothpaste containing smectite clay - Google Patents

Abstract

Disclosed is a toothpaste composition comprising: (i) 20 to 60 wt% of a calcium based abrasive; (ii) 3 to 15 wt% humectant; and, (iii) upto 2 wt% thickening silica; wherein the composition comprises 0.2 to 3 wt% smectite clay. Disclosed composition provides superior sensory profile as well as an increased uptake of antibacterial agent by the oral tissue.

Description

Toothpaste containing smectite clay

Invention field

The present invention relates to the dentifrice composition with outstanding organoleptic feature (sensoryprofile) and antibacterial action.

background of invention

Toothpaste is popular dentifrice product, and it contains abrasive material, one or more wetting agents, antibacterial, surfactant, thickening agent or binding agent and spice.

Multiple antibacterial is used in oral care product.The hydroxy diphenyl ether compound of such as halogenation, as Triclosan ^?(TCN) in oral care composition with to anti-plaque.The effect of antibacterial depends on to a great extent intraorally to be sent and absorbs.

Anion/amphion that US6451291B1 (Colgate, 2002) discloses mixing causes, to the increase of antibacterial picked-up, which increasing the therapeutic efficiency of this reagent.

US5188821A (Colgate, 1993) discloses the anionic polymerisation polycarboxylate (Gantrez of such as GAFCorporation ^?) be good antibacterial Contrast agent.

Disclose oral care composition in US2009269287A (P & G), wherein traditional wetting agent component (such as glycerol, sorbitol and other polyhydric alcohol) to a certain extent substitute by the bonding/thickened systems of the selectable carrageenin of tool.This Dentrifice composition demonstrates the dispersibility in the use of the enhancing in saliva, which provides the time of contact of the increase of compositions and user tooth and oral cavity tissue, and therefore activating agent can more promptly for useful activity.

But, still there is the unsatisfied demand sent and absorb to strengthening antibacterial.

Have in cost-benefit dentifrice composition attempting to provide, the present inventor manages to reduce wetting agent level.But as is expected, significantly reduce wetting agent and product can be caused to have poor organoleptic properties, it may can not obtain the acceptance of consumer.This present and how to balance the technical problem that organoleptic properties still can minimize cost simultaneously.

Surprisingly, determined that the minimizing of thickening silica dosage and the introducing of smectite clay provide solution.

summary of the invention

Disclose dentifrice composition according to first aspect, it has:

The calcio abrasive material of (i) 20 to 60 % by weight;

(ii) wetting agent of 3 to 15 % by weight; With,

(iii) thickening silica of as many as 2 % by weight;

Wherein, described compositions comprises the smectite clay of 0.2 to 3 % by weight.

Disclose the method promoting oral hygiene according to second aspect, it comprises the step of the dentifrice composition using the first aspect of effective dose to tooth.

The dentifrice composition for promoting the first aspect improving oral hygiene is disclosed according to the third aspect.

For a better understanding of the present invention, should with following detailed description of the preferred embodiments for reference.

detailed Description Of The Invention

Disclose dentifrice composition according to first aspect, it has:

The calcio abrasive material of (i) 20 to 60 % by weight;

(ii) wetting agent of 3 to 15 % by weight; With,

(iii) thickening silica of as many as 2 % by weight;

Wherein, described compositions comprises the smectite clay of 0.2 to 3 % by weight.

calcic abrasive material

All toothpaste is usually all containing grinding agent.Gel is usually containing silicon dioxide, but emulsifiable paste contains calcio abrasive material, particularly calcium carbonate.Need the amount balancing abrasive material, otherwise may excessive wear be there is.

Preferred dentifrice composition has the calcio abrasive material of 25 to 60 % by weight, more preferably the calcic abrasive material of 30 to 55 % by weight and most preferably 40 to 55 % by weight.

Particularly preferred abrasive material is calcium carbonate.The natural whiting (FGNC) (a kind of form of Chalk) of fine gtinding is highly preferred.

FGNC also can by carrying out chemistry or physical modification through heat treatment coating during grinding or after grinding.Typical coating material comprises magnesium stearate and magnesium oleate.The form of FGNC also can by using different grinding techniques to carry out modification during process of lapping, such as ball milling, air classification grinding (air-classifiermilling) or spiral spray grinding (spiraljetmilling).

FGNC can be used as unique calcio abrasive material.But FGNC also can make for balance abrasion together with other calcio abrasive material.Usually, the particle size of Chalk is 1 to 60 μm, and preferred size range is 1 to 15 μm.

Other preferred calcio abrasive material comprises dicalcium phosphate (DCP), calcium pyrophosphate and winnofil (PCC).

When using the combination of calcio abrasive material, preferred FGNC is 35 to 100%, more preferably 75 to 100% and particularly 95 to 100% of whole calcio abrasive material.In this case, surplus most preferably is PCC(winnofil).

Depend on the wear intensity of expection, other abrasive material also can use together with calcio abrasive material.These comprise the grinding and polishing agent of synthesis, such as Amorphous precipitated silica and silica gel.Other grinding agent comprises magnesium carbonate, Polymeric sodium metaphosphate., potassium metaphosphate, Zirconium orthosilicate., potassium metaphosphate, magnesium orthophosphate, tricalcium phosphate, magnesium orthophosphate, tricresyl phosphate magnesium, aluminium silicate, Zirconium orthosilicate. and perlite.

thickening silica

Disclosed compositions contains the thickening silica of as many as 2 % by weight.Conventional gel contains the thickening silica of as many as 8 % by weight, but opaque product has the thickening silica of 4 to 10 % by weight usually.The release of excessive thickening silica to fragrance component causes adverse influence.Preferred compositions have 1.5 % by weight or even less than 1 % by weight thickening silica.Optimal set compound has the thickening silica being less than 0.5 % by weight.

Preferred thickening silica comprises the AEROSIL from Degussa ^?t series or the CAB-O-SIL from CabotCorporation ^?series, silica gel is such as from the SYLODENT of W.R.Grace & CO ^?or SYLOX ^?series, or precipitated silica is such as from the ZEOTHIX of J.M.HuberCorporation ^?265.Available silicon dioxide thickening agents also comprises ZEODENT ^?165, ZEODENT ^?163 and/or 167 and ZEOFREE ^?153,177 and/or 265 silicon dioxide, it all can derive from J.M.HuberCorporation.Other preferred thickening silica comprises MFIL ^?, MFIL ^?-P (from MadhuSilica), SIDENT ^?22S and AEROSIL ^?200 (available from EvonikIndustries), SYLODENT from WRGrace & Company ^?and PERKASIL ^?thickening silica and the Tixosil from Rhodia ^?43 and 331, synthesize pyrolytic silicon dioxide in small, broken bits (syntheticfinelydividedpyrogenicsilica), such as, with trade mark SYLOID ^?244, SYLOID ^?266 and AEROSIL ^?d-200 sell those.

smectite clay

Dentifrice composition usually containing have an appointment 20 % by weight wetting agent, it typically is the combination of wetting agent.This needs the thickening silica comprising about 4 to 6 % by weight.This type of toothpaste has excellent organoleptic feature, therefore highly preferred by consumer.On the other hand, the product with about 6 to 10 % by weight wetting agents has more not preferred organoleptic feature, and it can be affected further when reducing the content of silicon dioxide.

Technical scheme is provided by smectite clay.Smectite constitutes the group be called as in the natural silicon aluminium acid salt mineral species of phyllosilicate.

Preferred smectite clay is selected from phyllosilicate, Montmorillonitum, bentonite, hectorite and its derivant, smectite clay (purifiedsodiummagnesiumsilicatesorganicallymodifiedsmect iteclay), organically-modified montmorillonitic clay and its mixture that the aluminium-magnesium silicate of purification, the sodium silicate magnesium of purification are organically-modified.

Preferred smectite clay is selected from Montmorillonitum (bentonite, hectorite and its derivant) further; (various grade can be used as VEEGUM to the aluminium-magnesium silicate of purification ^?be purchased from R.T.VanderbiltCompany); The sodium silicate magnesium of purification (can various grade as LAPONITE ^?be purchased); Organically-modified smectite, it comprises tetraalkyl and/or trialkyl ammonium smectite (organically-modified montmorillonitic clay), and such as oronain bentonite and Si La oronain hectorite and its mixture draw in quaternary ammonium salt-18 bentonite, quaternary ammonium salt-18 hectorite, department.Particularly preferably aluminium-magnesium silicate clay.An example is VEEGUM ^?hV.Upon exposure to water, this clay is tending towards expanding.

Preferred dentifrice composition contains the clay of 0.2 to 3 % by weight.Preferred compositions has the clay of 0.5 to 1 % by weight.

Smectite clay is considered to not only contributing to organoleptic feature works, but also contributes to thickener composition.

In preferred toothpaste, the ratio of calcic abrasive material and smectite clay is in the scope of 1:0.1 to 1:0.003.

wetting agent

Disclosed compositions has total wetting agent of 3 to 15 % by weight, more preferably 4 to 12 % by weight and most preferably 6 to 12 % by weight.Particularly preferred wetting agent is sorbitol, and it is usually with the form supply of 70% aqueous solution.Therefore, when using sorbitol as wetting agent, its actual dose in preparation higher than required percentage ratio so that the water in commercial product is counted.

Other preferred wetting agent comprises glycerol, maltose alcohol and xylitol.Preferred toothpaste contains glycerol and the sorbitol mouthfeel for lubrication, but their accumulation level should not exceed the disclosed upper limit.Lower humectant content also provides the effective method reducing product cost.

antibacterial

Preferred dentifrice composition comprises the antibacterial of 0.05 to 5 % by weight.

Suitable example comprises quaternary ammonium compound such as hexadecylpyridinium chloride; Two-biguanide is chlorhexidine, CHG (chlorhexidinedigluconate), hexetidine (hexetidine), octenidine (octenidine), alexidine (alexidine), TRICLOSAN such as ^?with other halogenated bisphenolic compounds such as 2,2' di-2-ethylhexylphosphine oxides-(the chloro-6-bromophenol of 4-).Particularly preferred antibacterial is TRICLOSAN ^?, it is the broad-spectrum antimicrobial agent be widely used in oral care product.In the compositions comprising antibacterial (preferred triclosan), we have observed the picked-up significantly high to antibacterial of the tissue of tooth that comprises tooth.This is the technique effect do not reported so far, and it is considered to the existence owing to smectite clay.

other binding agent

Preferred dentifrice composition also can have one or more other binding agents.Particularly preferably cellulosic binders.Preferred cellulosic binders comprises cellulose ether, and it comprises hydroxyethyl-cellulose (HEC), hydroxypropyl cellulose (HPC), ethylhydroxyethylcellulose (EHEC), carboxymethyl cellulose (CMC), carboxymethyl hydroxyethyl cellulose (CMHEC), hydroxypropylhydroxyethylcellulose cellulose (HPHEC), methylcellulose (MC), methylhydroxypropylcellulose (MHPC), methyl hydroxyethylcellulose (MHEC), carboxy methyl cellulose (CMMC), the carboxymethyl cellulose (HMCMC) of hydrophobically modified, the hydroxyethyl-cellulose (HMHEC) of hydrophobically modified, the hydroxypropyl cellulose (HMHPC) of hydrophobically modified, the ethylhydroxyethylcellulose (HMEHEC) of hydrophobically modified, the carboxymethyl hydroxyethyl cellulose (HMCMHEC) of hydrophobically modified, the hydroxypropylhydroxyethylcellulose cellulose (HMHPHEC) of hydrophobically modified, the methylcellulose (HMMC) of hydrophobically modified, the methylhydroxypropylcellulose (HMMHPC) of hydrophobically modified, the methyl hydroxyethylcellulose (HMMHEC) of hydrophobically modified and the carboxy methyl cellulose (HMCMMC) of hydrophobically modified.

Other cellulosic binders comprises cationic hydroxyethyl cellulose (cation HEC), the hydroxyethyl-cellulose (cation HMHEC) of cation hydrophobic modification and microcrystalline Cellulose.

Highly preferred binding agent is sodium carboxymethyl cellulose (SCMC).It is 0.6 to 0.99 that particularly preferred sodium carboxymethyl cellulose comprises substitution value, preferably 0.7 to 0.95 those.Further, it is those of 250mPa.s to 10000mPa.s that preferred SCMC comprises viscosity, described viscosity as 30rpm, measure on BrookfieldviscometerTAspindle at 23 DEG C and when with reading after 30 seconds during the ratio pulping of spice with 1:1.

Except cellulosic binders, or as the substitute of cellulosic binders, guar gum or derivatives thereof can be used.But, relative fiber element binding agent this type of binding agent more not preferred.This analog derivative comprises carboxymethyl guar gum (CM guar gum), molar substitution degree (HE guar gum), hydroxypropyl guar gum (HP guar gum), Carboxymethyl hydroxypropyl guar (CMHP guar gum), cation guar gum, the guar gum (HM guar gum) of hydrophobically modified, the carboxymethyl guar gum (HMCM guar gum) of hydrophobically modified, the molar substitution degree (HMHE guar gum) of hydrophobically modified, the hydroxypropyl guar gum (HMHP guar gum) of hydrophobically modified, the hydroxypropyl guar gum (cation HMHP guar gum) of cation hydrophobic modification, the Carboxymethyl hydroxypropyl guar (HMCMHP guar gum) of hydrophobically modified and the cation guar gum (HM cation guar gum) of hydrophobically modified.

Other more not preferred glue comprises xanthan gum, carrageenin and derivant, such as Irish moss and viscarin, gellan gum, sclerotium gum (sclerotiumgum) and derivant, amylopectin, rhamsan gum (rhamsangum), Wei Lan glue (welangum), Rhizoma amorphophalli, curdlan (curdlan), algin, alginic acid, alginate and derivant, starch phosphate ester derivant, agar and derivant, Radix Acaciae senegalis and derivant, pectin and derivant, chitosan and derivant, karaya (karayagum), locust bean gum (locustbeangum), natto gum (nattogum), Tragacanth, chitin derivative, gelatin, beta glucan, dextrin, dextran, cyclodextrin and polyquaternary ammonium salt, furan foamed resin (furcellarengum), ghatti gum (ghattigum), plantasan (psylliumgum), WENBO natural gum (quincegum), tamarind gum, larch glue (larchgum) and tara gum (taragum).

Binding agent is that compositions provides main body.In order to viscosity and the binding ability of balanced combination thing, often all need the balance reached between smectite clay and binding agent when present.Such as, if be incorporated in compositions by more smectite clay, preferably binder content can be reduced.When having the preparation of thickening silica and smectite clay and binding agent, need the impact considering their individualities, because these effects produce accumulative effect usually.Such as, when compositions contains thickening silica, need carefully to control binder content otherwise the paste (paste) that may cause thickness.

When compositions also has cellulosic binders except smectite clay, the ratio of the amount of smectite clay and cellulosic binders is in the scope of 1:0.2 to 1:0.9.Excessive cellulosic binders causes when compositions being dispensed on toothbrush, and compositions may demonstrate smearing.On the other hand, most of cellulosic binders and some other binding agents such as carrageenin are expensive composition.Therefore, their use can improve the viscosity of product, and this selection may be viable commercial.

other composition

Except previously described composition, preferred compositions also can comprise one or more other compositions as described below.

other thickening agent

Preferred dentifrice composition also can comprise one or more other thickening agent, such as carboxy vinyl polymers, and it comprises can from B.F.Goodrich as CARBOPOL ^?series (comprises CARBOPOL ^?934,940,941 and 956) carbomer (carbomer) be purchased.

Other preferred grade comprises acrylate/acrylic acid C _10-30alkyl ester cross-linked polymer, it can from NoveonCorporation as ULTREZ ^?21, PEMULEN ^?tR-1 and PEMULEN ^?tR-2 is purchased.Preferred compositions can comprise other thickening agent of 0.05 to 10 % by weight, more preferably 0.1 to 5 % by weight and even more preferably 0.25 to about 4 % by weight.

desensitizer

Desensitizer is the potassium salt being selected from potassium nitrate, potassium chloride, potassium citrate, Soluble tartar. and potassium acetate, and it preferably uses with 0.5 to 3 % by weight, more preferably 1 to 2.5 % by weight and particularly 1.7 to 2.2 % by weight.

silicate

Preferred dentifrice composition can comprise alkali silicate.This alkali metal is sodium or potassium, is preferably sodium.Sodium silicate usually with 10 to 40% aqueous solution, the most normally form supply of solution of 30%.Sodium silicate can the form supply of neutral sodium silicate or alkaline sodium silicate.Preferred toothpaste has neutral sodium silicate.The Na with different ratio can be supplied ₂o:SiO ₂sodium silicate.

There is the Na of 3.0 to 3.8 scopes ₂o:SiO ₂the sodium silicate of ratio be preferred, more highly preferred scope is 3.25 to 3.5.Preferred toothpaste comprises the silicate (on dry weight basis) of 0.1 to 5 % by weight.Therefore, by the sodium silicate solution of 30% with 0.3 to 16 % by weight amount join in compositions.

caries preventive agent

Preferred compositions can comprise one or more caries preventive agents.This type of reagent is generally fluoride.Preferably the source of fluoride is the alkali metal salt of single fluorophosphoric acid, preferred sodium monofluorophosphate (SMFP).

When mentioning the dentifrice composition with calcio abrasive material (particularly Chalk), SMFP is the fluoride source selected; Because substituting sodium fluoride and calcium carbonate reaction form insoluble calcium fluoride, it has limited anticariogenic activity.Preferred compositions comprises the caries preventive agent of 0.01 to 2 % by weight, more preferably 0.15 to 1 % by weight and particularly preferably 0.2 to 0.5 % by weight.The concentration of preferred maintenance free fluoride ion is 100 to 2000ppm, preferably 900 to 1500ppm.Other preferred caries preventive agent comprises sodium fluoride and stannous fluoride, amine fluoride (aminefluoride), sodium trimetaphosphate and casein.

antiseptic

There is the toothpaste of calcic abrasive material (particularly Chalk), be easy to bacterial growth.Some antiseptic, the methyl of such as P-hydroxybenzoic acid, ethyl, butyl, propyl group and isopropyl esters can be used for resisting bacterial growth especially.The particularly preferably mixture of the methyl of P-hydroxybenzoic acid, ethyl, butyl and propyl diester.The activity of this mixture can be strengthened by adding phenyl phenol.Formaldehyde and dimethyl hydantoin are other preferred antiseptic.Usually antiseptic is comprised with 0.05 to 0.8 % by weight.

antioxidant

Preferred antioxidant is can those of with other component compatibility and not health risk.These comprise ascorbic acid, ascorbic palmitate, thio-2 acid, calcium ascorbate, dithiopropionic acid two lauryl, guaiac (gumguaiac), sodium ascorbate, butylated hydroxy-methylbenzene, butylated hydroxyanisol and tocopherol.The mixture of antioxidant can be used.

When it is present, add antioxidant with the level effectively reduced or relax variable color, otherwise variable color can be caused by the oxidation of toothpaste component.Preferred levels is 0.01 to 1 % by weight.

surfactant

Toothpaste generally containing surfactant, is also referred to as foaming agent usually.Those of foam reasonably stablized and can provide within the scope of whole wide pH by suitable surfactant.Surfactant can be anion, nonionic, both sexes, amphion, cationic surfactant or its mixture.

Anion surfactant used herein is included in alkyl the water soluble salt of the sulfonate monoglycerides of the fatty acid having the water soluble salt of the alkyl sulfate of 8 to 20 carbon atoms (such as alkyl sodium sulfate) and have 8 to 20 carbon atoms.Sodium lauryl sulfate and sodium coconut m ester sodium sulfonate (sodiumcoconutmonoglyceridesulfonate) are the examples of such anion surfactant.Other suitable anion surfactant is sarcosinate, such as sodium lauroyl sarcosine, taurate, sulfoacetic acid Lauryl Ester sodium, lauroyl sodium isethionate, laureth carboxylic acid sodium and dodecylbenzene sodium sulfonate.

Non-ionic surface active agent broadly can be defined through the compound that alkylen groups (hydrophilic nmature) produces with the condensation of organic hydrophobic compound that can be aliphatic series or alkyl-aromatic character.

Suitable non-ionic surface active agent example comprises poloxamer (with trade name PLURONIC ^?sell), polyoxyethylene, polyoxyethylene sorbitol acid anhydride ester be (with trade name TWEENS ^?sell), POLYOXYL ^?the mixture of the ethylene oxide condensate of the polyethylene oxide condensation compound of 40 castor oil hydrogenated, alcohol ethoxylate, alkyl phenol, the product being derived from the product condensation of oxirane and expoxy propane and ethylenediamine, aliphatic alcohol, long chain tertiary amine oxides, long chain tertiary phosphine oxide, long chain dialkyl sulfoxides and this type of material.Non-ionic surface active agent Poloxamer ^?407 is one of most preferred surfactants, because contribute to reducing astringent taste to the use of Poloxamer.

Available amphoteric surfactant broadly can be described as the derivant of aliphatic secondary amine and tertiary amine, wherein aliphatic group is straight chain or side chain, and one wherein in aliphatic substituent group containing have an appointment 8 to about 18 carbon atoms and one such as, containing anionic water solubilization radical, carboxylate radical, sulfonate radical, sulfate radical, phosphate radical or phosphonate radical.Other suitable amphoteric surfactant is betanin, particularly cocamidopropyl betaine.Also the mixture of amphoteric surfactant can be used.Preferred levels is 0.25 to 12 % by weight, preferably 0.5 to 8 % by weight and most preferably 1 to about 6 % by weight.

sweeting agent

Toothpaste also can contain sweeting agent.Preferred sweeting agent comprises saccharin sodium, aspartame (aspartame), sucralose, Talin (thaumatin), acesulfame potassium (acesulfamepotassium), stevioside (stevioside), Stevia rebaudiana (Bertoni) Hemsl extract, p-met hoxycinnamic aldehyde, neohesperidin dihydrochalcone (neohesperidyldihydrochalcone) and Folium Perillae roripa.Levels typical is 0.005 to 5 % by weight, more preferably 0.01 to 1 % by weight.

Preferred toothpaste can comprise one or more bleachs, such as per-compound as peroxide diphosphonic acid potassium, effervescent system as sodium bicarbonate/citric acid system, variable color system and 0.001 to 6 % by weight, preferably 0.5 to 4 % by weight chelating agen, it comprises the alkali metal salt of citric acid, alanine, glycine and serine.

The most preferably alkali metal salt of citric acid, particularly potassium citrate and most preferred potassium citrate.

Liposome may be used for improving sending or stability of one or more active component.Preferred compositions also can comprise one or more in breath strip (breathstrip), bubble (sparkle), large silica dioxide granule, particle (granule), beadlet and flavor capsule to strengthen organoleptic benefits or visual attraction.

Also in order to opacity, titanium dioxide can be joined in compositions.Usually the titanium dioxide of 0.25 to 5 % by weight is comprised.

Preferably dentifrice composition contains spice.Suitable flavor components comprises wintergreen oil, Oleum menthae, Oleum Menthae Rotundifoliae, Flos Caryophylli oil (clovebudoil), menthol, anethole, methyl salicylate, eucalyptole, Cortex Cinnamomi (cassia), acetic acid 1-menthyl ester, Salvia japonica Thunb., eugenol, parsley oil, raspberry ketone (oxanone), α-ionone, Origanum majorana L., Fructus Citri Limoniae, orange, 1-ethoxy-2-hydroxy-4-propenyl benzene, Cortex cinnamomi japonici (Ramulus Cinnamomi) (cinnamon), vanillin, ethyl vanillin, heliotropine, 4-cis-heptenal, diacetyl, methyl-p-tert-butyl benzene yl acetate and its mixture.Freshener also can become a part for perfume systems.Preferred freshener is to terpane carboxyamide agents, and such as N-Ethyl-p-menthane-3-Methanamide (is commercially called " WS-3 ^?") and its mixture.This spice is generally 0.001 to 5 % by weight.

physical property

When at 1/s and 25 DEG C, use BROOKFIELD ^?viscometer is at 5rpm(rev/min) under when using T-barD-spindle to measure, the viscosity of preferred dentifrice composition is 80,000 to 500,000cps.The viscosity of preferred dentifrice composition is 100,000 to 200,000cps further.

method

Disclose the method promoting oral hygiene according to second aspect, it comprises the step of the dentifrice composition using the first aspect of effective dose to tooth.

purposes

The dentifrice composition of first aspect is disclosed for promotion oral hygiene according to the third aspect.

By means of nonrestrictive exemplary, the present invention will be described now.

Embodiment

embodiment 1: the qualitative description of preferred compositions and contrast dentifrice composition analyzes (QDA)

Make preferred dentifrice composition to study for QDA.Also some Comparative composition are prepared.The composition of each toothpaste is described in table 1.

table 1

Composition	C-1	C-2	C-3	C-4	X	Y
							Sorbitol ﹡	10.0	10.0	15.0	10.0	10.0	10.0
Calcium carbonate	40.0	40.0	40.0	40.0	45.0	50.0
							Thickening silica	3.7	3.7	4.5	4.5	2.0	2.0
Veegum ? HV	-	-	-	-	0.8	0.8
							SCMC	0.7	0.7	0.6	0.6	0.6	0.6
SLS	2.5	2.5	2.5	2.5	2.5	2.5
							Water and secondary thing are extremely	100	100	100	100	100	100

annotation:

A () compositions C1 to C4 is reference composition, and X and Y is the preferred embodiment of invention disclosed.

B () ﹡-this is the actual percentage of sorbitol.

Convene the group of trained expert consumer syndic.Require often kind of compositions in each group member's use table 1.After brushing teeth, as shown in table 2, each volunteer specifies mark (scale by design in advance 1 to 10) to selected sensory attribute.Mark 1 is considered as minimum score and 10 is largest score.When all syndics evaluate the compositions of full, statistical analysis is carried out to mark.Require that some consumers use (and evaluation) has the commercially available competing product of about 20% sorbitol.Above-mentioned statistical data analysis is also shown in table 2,3 and 4.

table 2

Sensory attribute	C-1	X	Y
				Foam volume	5.48	5.61	5.57
Foam butterfat sense (creaminess)	5.55	5.67	5.62
				Flavor strength when brushing teeth	5.35	5.44	5.48
Cooling feeling during brushing teeth	5.45	5.44	5.46
				Oral area freshness after gargling	5.57	5.64	5.76
Flavor strength after gargling	5.12	5.23	5.22

table 3

Sensory attribute	Commercially available competing product	C-2	C-1	X
					Foam volume	5.58	5.46	5.41	5.54
The sense of foam butterfat	5.60	5.47	5.44	5.51
					Flavor strength during brushing teeth	5.46	5.41	5.26	5.46
Cooling feeling during brushing teeth	5.54	5.47	5.26	5.59
					Cooling feeling after gargling	5.94	5.58	5.61	5.96
Oral area freshness after gargling	5.91	5.80	5.60	5.99
					Flavor strength after gargling	5.21	5.17	4.99	5.23

table 4

Sensory attribute	C-3	C-4	X
				Foam volume	5.50	5.40	5.51
The sense of foam butterfat	5.47	5.38	5.48
				Flavor strength during brushing teeth	5.43	5.38	5.43
Cooling feeling after gargling	5.84	5.80	5.92

Data in the table-2 that associative list-1 is read show for most attribute, and each preferred compositions X and Y is better than reference composition C-1 on sense organ.As by table-1 clear and definite, substantial differences in preparation is whether smectite clay exists the percentage ratio with thickening silica, both provides this type of any benefit to be unknown so far, is particularly brushing teeth in period and foam afterwards, its butterfat sense and flavor strength.Therefore, consider the known benefit of smectite clay, viewed technique effect is beyond thought.

Data in table-3 show that preferred compositions X [although its significantly lower humectant content] is equal to the commercially available competing product had up to about 20 % by weight sorbitol (on the basis of 100%) on sense organ.Also in this case, the known benefit considering smectite clay and the benefit (if present) brought by minimizing thickening silica, viewed technique effect is beyond thought.On the other hand, again the inferior position of Comparative composition C-1 and C-2 on sense organ is found.

Data in table 4 further demonstrate that previous discovery and have consolidated the observed result described before.

embodiment 2: smectite clay is on the impact of being absorbed antibacterial by tissue of tooth

Prepare the preferred dentifrice composition had as preparation in table 5.

table 5

Composition	% by weight
		Sorbitol (reality)	10.5
Calcium carbonate	45.0
		Thickening silica	2.0
Triclosan	0.3
		Veegum	0.8
SCMC	0.4
		SLS	2.5
Water and secondary thing	To 100

Formation has the group of 40 trained human volunteers for double blinding, random, complete intersection research.Require that each syndic brushes teeth by the compositions of table-5.In order to relative analysis, also require that each syndic does not brush teeth containing the toothpaste based on Chalk containing triclosan of smectite clay with commercially available.But collect dental plaque sample in difference fixed time interval after brushing teeth.Measured the concentration of triclosan in dental plaque sample by HPLC, and it the results are shown in table 6.

table 6

。

Tables of data in table 6 understands the statistically significant difference (when 95% confidence level) being conducive to preferred composition.When preferred composition, the concentration of the triclosan of each interval is higher all significantly.Decline gradually in time although the practical level of triclosan demonstrates as expected, the more important thing is and pass even in time, the commercially available toothpaste of preferred composition relative contrast of table-5 still keeps the observed result of its advantage.

embodiment 3: by the comparative study of the antibacterial effect of in vitro method

Describe the research than the more preferably antibacterial activity of dentifrice composition in this experiment.Its effectiveness about triclosan and reservation are measured, and compare with the commercially available calcio toothpaste containing 0.3% triclosan.

At HAP(hydroxyapatite) coil on biomembrane production models and use Streptococcus mutans ATCC25175 to study this effect through 4 hours.

Employing time method for disinfection (timekillbactericidalapproach).After HAP dish hatching Streptococcus mutans 4 hours with saliva coating and toothpaste process, calculating maintenance depends on organic total viable count of HAP dish.The toothpaste providing minimum total viable count is considered to best.

Table 7 demonstrates after the hatching of 4 hours and dentifrice treatment, depends on total viable count of the Streptococcus mutans of HAP dish.

table 7

Product	Experiment-1 (log 10)	Experiment-2 (log 10)	Experiment-3 (log 10)
				Contrast [water]	4.88	4.35	4.37
There is the commercially available competition toothpaste of 0.3% triclosan	3.73	3.76	3.10
				Compositions in table 5	2.74	2.48	2.54
Standard add fluorine toothpaste	4.36	3.86	3.75

Data in table 7 show that, in the often group of three groups of experiments, preferred compositions provides minimum total viable count [log ₁₀] value, therefore it shows that the antibacterial effect of preferred composition is better than Comparative composition.

Therefore, preferred compositions reduces the growth of Streptococcus mutans in significantly better degree compared to other toothpaste.

The embodiment illustrated shows that the dentifrice composition containing smectite clay and relatively low amount thickening silica can provide outstanding organoleptic feature, and increase via the picked-up of oral cavity tissue to antibacterial.

Should be understood that the concrete form of the invention illustrated and describe is intended to be only representational herein, therefore can make some when clearly instructing disclosed in not deviating from wherein and change.

Although describe the present invention according to specific embodiment, it will be appreciated by those skilled in the art that the present invention can other forms many implement.

Claims (11)

1. dentifrice composition, it comprises:

The calcio abrasive material of (i) 20 to 60 % by weight;

(ii) wetting agent of 3 to 15 % by weight; With,

(iii) thickening silica of as many as 2 % by weight;

Wherein, described compositions comprises the smectite clay of 0.2 to 3 % by weight.

2. dentifrice composition as described in claim 1, it comprises the antibacterial of 0.05 to 5 % by weight.

3. dentifrice composition as described in claim 2, wherein said antibacterial is triclosan.

4., as dentifrice composition in any one of the preceding claims wherein, the ratio of wherein said calcic abrasive material and described smectite clay is in 1:0.1 to 1:0.003 scope.

5., as dentifrice composition in any one of the preceding claims wherein, wherein said smectite soil is selected from organically-modified smectite clay, organically-modified montmorillonitic clay and its mixture of sodium silicate magnesium of phyllosilicate, Montmorillonitum, bentonite, hectorite and its derivant, the aluminium-magnesium silicate of purification, purification.

6. dentifrice composition as described in claim 5, wherein said smectite clay is aluminium-magnesium silicate clay.

7., as dentifrice composition in any one of the preceding claims wherein, it comprises the cellulose thickener of 0.1 to 5 % by weight.

8., as dentifrice composition in any one of the preceding claims wherein, wherein said abrasive material is calcium carbonate.

9., as dentifrice composition in any one of the preceding claims wherein, the viscosity of wherein said compositions is 80,000 to 500,000cps.

10. promote the method for oral hygiene, it comprises the step of the dentifrice composition as described in claim 1 using effective dose to tooth.

11. for promoting the dentifrice composition as described in claim 1 of oral hygiene.