CN105130083A - Method for removing endotoxin and foreign ions in low-deuterium target washing water - Google Patents
Method for removing endotoxin and foreign ions in low-deuterium target washing water Download PDFInfo
- Publication number
- CN105130083A CN105130083A CN201510615563.6A CN201510615563A CN105130083A CN 105130083 A CN105130083 A CN 105130083A CN 201510615563 A CN201510615563 A CN 201510615563A CN 105130083 A CN105130083 A CN 105130083A
- Authority
- CN
- China
- Prior art keywords
- target water
- low deuterium
- washes
- intracellular toxin
- low
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
The invention relates to a method for removing endotoxin and foreign ions in low-deuterium target washing water. The method comprises steps: removing part of endotoxin and foreign ions in low low-deuterium target washing water raw material with two-level distilling, and filtering and removing residual endotoxin in the low-deuterium target washing water with an ultrafiltration membrane. Compared with prior art, under the premise that abundance of deuterium (D) is not increased in the low-deuterium target washing water and other foreign ions are not introduced in a final product, part of endotoxin and foreign ions in the low-deuterium target washing water are removed by the two-level distilling, and then most endotoxins and foreign ions in the low-deuterium target washing water are removed by the ultrafiltration membrane, thus realizing that the endotoxin and foreign ions in the low-deuterium target washing water are up to standard. The method is simple and convenient, guarantees products quality and consumes less low-deuterium target washing water.
Description
Technical field
The present invention relates to the treatment process that low deuterium washes target water, especially relate to and a kind ofly remove the method that low deuterium washes intracellular toxin and ion in target water.
Background technology
In Positron Emission Computed Tomography technology (PositronEmissionComputedTomography, PET), need to bombard with magnetic resonance acceleator
18o thus obtain Value linear ion, then inject in body by preparing radiopharmaceuticals with on-radiation raw material through nucleophilic substitution reaction.The target film cleanliness factor bombarded in magnetic resonance acceleator used and ion content are related to the rate of recovery of medicine; This target film is expensive, bombard the residual impurity in rear surface and easily cause corrosion to it and reduce its work-ing life, therefore want often clean it and remain without any, and common medical water cleaning performance is not good.
It is be specifically designed to the reagent cleaning above-mentioned magnetic resonance acceleator that low deuterium washes target water, it has the chemical property almost identical with ortho-water, its distinctive small molecular cluster structure can dissolve the impurity on target film faster, more common medical water also can recover faster, can realize playing good cleanup action to accelerator target film and remaining and corrosion without any.
Very harsh to index requests such as specific conductivity, total organic carbon and bacterial endotoxins thereof owing to washing target fishery products, domestic Jin You only a few unit can provide product.And the present invention washes target water for the domestic low deuterium developing Shanghai Chemical Research Inst's production of this product first to carry out.
At present, domestic low deuterium washes target, and aquatic to produce what adopt be water rectification method, and the low deuterium that this kind of method obtains is washed containing bacterial endotoxin in target water, washes target water carry out being attached to target film surface in cleaning process at the low deuterium of use, reduce the cleanliness factor of target film, even intracellular toxin is incorporated in synthetic drugs.
Intracellular toxin is the lipopolysaccharides material resulting from gram negative bacterial cell outer wall layer, that is the fragment of bacterium corpse.Intracellular toxin generally exists with dimer form, and its phosphate group and divalent-metal ion chelating can stablize that intracellular toxin is intermolecular to be polymerized further, facilitate larger intracellular toxin complex body, the molecular weight of this kind of complex body can by several thousand to tens million of not etc.Intracellular toxin has the characteristics such as volume is little, thermostability is strong, chemical stability is strong, makes it acquire a certain degree of difficulty in being removed.
The method of carrying out endotoxin removal is at present mainly charcoal absorption, extraction, ultra-filtration technique, ion-exchange chromatography process etc., and generally adopts ultra-filtration technique for the intracellular toxin process in liquid, biotechnological formulation or injection liquid.
" in water endotoxic concentration level and removal effect progress " (Huang Huang etc., engine hygiene magazine, volume the 3rd phase June the 3rd in 2013) disclose the test method of endotoxin removal in water is comprised: the methods such as charcoal absorption, coagulating sedimentation filtration, sterilization, test shows that sedimentation and filtration all can remove certain intracellular toxin with sterilization.
Active carbon adsorption gac used needs through filtering, and film bag used needs often to change, and the intracellular toxin in gac is also likely released thus causes the bounce-back of endotoxin content, and whole process is wayward; Sedimentation and filtration can remove certain intracellular toxin, but is generally applicable to use when processing relatively large water, and can not arrive the requirement of water for injection endotoxin content; The conventional sterilization such as chlorine, ozone, ultraviolet can cause low deuterium to wash the rising of target water conductivity, and the danger of chlorine disinfectant method own is comparatively large, also can introduce foreign ion and cause exceeding standard of product chloride ion content.
Wash target water due to low deuterium and easily absorb the carbonic acid gas in air thus the rising causing product specific conductivity; Easily introduce bacterium, air suspension thing in atmosphere, water vapour easily and in air occurs exchange thus cause low deuterium to wash the rising of D abundance in target water, affect its small molecular cluster structure, therefore under not raising and not introducing foreign ion prerequisite in D abundance, the finished product, not yet have at present and wash target water for low deuterium and remove endotoxic short-cut method.
Summary of the invention
Object of the present invention is exactly provide a kind of method that low deuterium washes intracellular toxin and foreign ion in target water of removing to overcome defect that above-mentioned prior art exists, and the inventive method obtains when not raising D abundance, when not introducing foreign ion in the final product the low deuterium that intracellular toxin is up to standard, specific conductivity is qualified and washes target fishery products.
Object of the present invention can be achieved through the following technical solutions:
Remove the method that low deuterium washes intracellular toxin and foreign ion in target water, first utilize two-step distillation to remove low deuterium and wash part intracellular toxin in target water coarse raw materials and foreign ion, then remove low deuterium through ultrafiltration membrance filter and wash remaining intracellular toxin in target water.
The method comprises the following steps:
(1) first time distillation: low deuterium is washed in target water raw material and add alkaline hydrated oxide, basic oxide or high activity alkali metal, be mixed with strong base solution, put into water distilling apparatus and distill, obtain single flash liquid;
Described alkaline hydrated oxide comprises sodium hydroxide, potassium hydroxide or calcium hydroxide etc., described basic oxide comprise sodium oxide and potassium oxide etc., described high activity alkali metal comprises potassium or sodium etc., but due to high activity alkali metal with water reaction process in can vigorous reaction, discharge a large amount of heat, need take care in operation, therefore this step preferably adopts the alkaline hydrated oxide such as sodium hydroxide or potassium hydroxide.
(2) second time distillation: single flash liquid is put into water distilling apparatus, and adds Vanadium Pentoxide in FLAKES and be mixed with phosphoric acid solution, distill, obtain second distillation liquid;
The object of preparation phosphoric acid solution is a small amount of alkaline matter neutralization of will carry secretly in first time still-process; And it is not phosphoric acid solution is more stable, volatile, and common hydrochloric acid, nitric acid easily volatilize, and can enter into second distillation liquid, affect specific conductivity and the ion content of product; All can contain the composition of water in common hydrochloric acid, nitric acid, sulfuric acid, can have influence on the content of deuterium in product, and adopt corresponding oxide compound and water to react inconvenient, therefore second time prepares phosphoric acid solution in filtering.
(3) ultrafiltration membrance filter: adopt ultra-filtration membrane to filter second distillation liquid, filtration end obtains the qualified product that D abundance does not raise, endotoxin content is up to standard, specific conductivity is qualified.
The alkaline hydrated oxide, basic oxide or the high activity alkali metal that add in step (1) are analytical pure and above purity, and after dissolving, the massfraction of gained strong base solution is not more than 1mol/L.
In step (2), Vanadium Pentoxide in FLAKES used is analytical pure and above purity, and the concentration of phosphoric acid solution is 0.1mol/L-5mol/L.
Water distilling apparatus used in step (1) and step (2) is Rotary Evaporators or distilled water generator.
Still-process in step (1) and step (2) is that nitrogen, argon gas or the helium being greater than more than 99.99% in purity carries out as protecting in the environment of gas.
In step (3), the molecular weight cut-off of ultra-filtration membrane used is equal to or less than 10KD.
In step (3), ultra-filtration membrane material used is polyethersulfone or composite regenerated Mierocrystalline cellulose.
The abundance scope that low deuterium described in step (1) washes the deuterium of target water raw material is 1ppm to 149ppm.
High-purity hydrogen sodium oxide or potassium hydroxide dissolution of solid are washed in target water at low deuterium and are formed strong base solution by the present invention, endotoxic active structure can be destroyed due to strong alkali environment thus make its inactivation, therefore decompose low deuterium wash most of intracellular toxins in target water by adding highly basic, and by twice distillation, introducing impurity and low deuterium are washed target water and be separated, obtain washing target water containing a small amount of endotoxic low deuterium, again by the ultrafiltration membrance filter of suitable molecular weight cut-off, remove low deuterium to wash in target water remaining or period and operate a small amount of intracellular toxin brought, the low deuterium obtaining endotoxin content up to standard washes target fishery products.
The present invention devises the process of twice distillation, and first time distillation can not be exchanged with the order that second time is distilled, and enters in second distillation because the alkali added in single flash can be carried secretly, if exchange easily to be incorporated in product, the specific conductivity of product is raised.
The treatment process that the present invention adopts twice distillation to combine with ultrafiltration, independent ultrafiltration membrance filter can realize endotoxic removal, but film packet loss is serious, and some ions and small molecule structure can not well be removed, thus makes its specific conductivity not up to standard.Because prevent from carrying secretly or volatilizing, a lot of soda acids is not added in twice still-process, have a small amount of intracellular toxin to have little time to react just to be carried secretly to enter next stage, although seldom, but in order to remove as far as possible, so have employed two kinds of methods combining process, whole process is not loaded down with trivial details, and can control its quality product preferably.
Compared with prior art, the inventive method can obtain intracellular toxin, specific conductivity oxygen all up to standard 18 product when not raising the D abundance in product, when not introducing foreign ion in the final product, and it is easy and simple to handle, instrument can use for a long time continuously, the replacement frequency of ultra-filtration membrane bag is less, and material loss is also less.
Accompanying drawing explanation
Fig. 1 is the process flow sheet of the inventive method.
Embodiment
Below in conjunction with the drawings and specific embodiments, the present invention is described in detail.
Embodiment 1
Treatment process is with reference to the technical process shown in figure 1.
Industrial low deuterium washes target water, D abundance is 5ppm, endotoxin content is 25EU/ML, specific conductivity is 3 μ s/cm, add the sodium hydroxide that purity is 99.6%, be made into the sodium hydroxide solution of 0.5mol/L, the high-purity argon put into purity is 99.999% carries out single flash as protecting the distilled water generator of gas, then be that the high-purity argon of 99.999% is as in the distilled water generator of protection gas using single flash liquid introducing purity, and add purity be 99.99% Vanadium Pentoxide in FLAKES be mixed with the phosphoric acid solution of 0.5mol/L, carry out second distillation, gained second distillation liquid is 3000 by molecular weight cut-off, membrane area is the ultra-filtration membrane bag of the polyethers maple material of 200 square centimeters, filtration end obtains intracellular toxin lower than 0.01EU/ML, specific conductivity is 0.21 μ s/cm, D abundance is that the low deuterium of 5ppm washes target water.
Embodiment 2
Industrial low deuterium washes target water, D abundance is 25ppm, endotoxin content is 20EU/ML, specific conductivity is 4.1 μ s/cm, add the sodium hydroxide that purity is 99.6%, be made into the sodium hydroxide solution of 0.2mol/L, the high-purity argon put into purity is 99.999% carries out single flash as protecting the distilled water generator of gas, then being put into by single flash liquid by purity is that the high-purity argon of 99.999% is as the distilled water generator protecting gas, and add purity be 99.99% Vanadium Pentoxide in FLAKES be mixed with the phosphoric acid solution of 1mol/L, carry out second distillation, gained second distillation liquid is 5000 by molecular weight cut-off, membrane area is the ultra-filtration membrane bag of the renewable Mierocrystalline cellulose material of 50 square centimeters, filtration end obtains intracellular toxin lower than 0.05EU/ML, specific conductivity is 0.2 μ s/cm, D abundance is that the low deuterium of 25ppm washes target water.
Embodiment 3
Industrial low deuterium washes target water, D abundance is 100ppm, endotoxin content is 25EU/ML, specific conductivity is 3.5 μ s/cm, add the sodium hydroxide that purity is 99.6%, be made into the sodium hydroxide solution of 0.2mol/L, the high-purity argon put into purity is 99.999% carries out single flash as protecting the distilled water generator of gas, then being put into by single flash liquid by purity is that the high-purity argon of 99.999% is as the distilled water generator protecting gas, and add purity be 99.99% Vanadium Pentoxide in FLAKES be mixed with the phosphoric acid solution of 0.5mol/L, carry out second distillation, gained second distillation liquid is 3000 by molecular weight cut-off, membrane area is the ultra-filtration membrane bag of the polyethers maple material of 50 square centimeters, filtration end obtains intracellular toxin lower than 0.01EU/ML, specific conductivity is 0.10 μ s/cm, D abundance is that the low deuterium of 100ppm washes target water.
Embodiment 4
Industrial low deuterium washes target water, D abundance is 1ppm, endotoxin content is 20EU/ML, specific conductivity is 4.5 μ s/cm, add the sodium hydroxide that purity is 99.6%, be made into the sodium hydroxide solution of 0.5mol/L, the high-purity argon put into purity is 99.999% carries out single flash as protecting the distilled water generator of gas, then being put into by single flash liquid by purity is that the high-purity argon of 99.999% is as the distilled water generator protecting gas, and add purity be 99.99% Vanadium Pentoxide in FLAKES be mixed with the phosphoric acid solution of 5mol/L, carry out second distillation, gained second distillation liquid is 5000 by molecular weight cut-off, membrane area is the ultra-filtration membrane bag of the polyethers maple material of 50 square centimeters, filtration end obtains intracellular toxin lower than 0.05EU/ML, specific conductivity is 0.12 μ s/cm, D abundance is that the low deuterium of 1ppm washes target water.
Embodiment 5
Industrial low deuterium washes target water, D abundance is 149ppm, endotoxin content is 50EU/ML, specific conductivity is 3.8 μ s/cm, add the sodium hydroxide that purity is 99.6%, be made into the sodium hydroxide solution of 0.5mol/L, the high-purity argon put into purity is 99.999% carries out single flash as protecting the distilled water generator of gas, then being put into by single flash liquid by purity is that the high-purity argon of 99.999% is as the rotatory evaporator protecting gas, and add purity be 99.99% Vanadium Pentoxide in FLAKES be mixed with the phosphoric acid solution of 0.1mol/L, carry out second distillation, gained second distillation liquid is 10000 by molecular weight cut-off, membrane area is the ultra-filtration membrane bag of the renewable Mierocrystalline cellulose material of 50 square centimeters, filtration end obtains intracellular toxin lower than 0.1EU/ML, specific conductivity is 0.28 μ s/cm, D abundance is that the low deuterium of 149ppm washes target water.
Embodiment 6
Industrial low deuterium washes target water, D abundance is 1ppm, endotoxin content is 20EU/ML, specific conductivity is 4.5 μ s/cm, add the sodium oxide that purity is 99.6%, be made into the sodium hydroxide solution of 0.5mol/L, the high pure nitrogen put into purity is 99.999% carries out single flash as protecting the distilled water generator of gas, then being put into by single flash liquid by purity is that the high pure nitrogen of 99.999% is as the distilled water generator protecting gas, and add purity be 99.99% Vanadium Pentoxide in FLAKES be mixed with the phosphoric acid solution of 3mol/L, carry out second distillation, gained second distillation liquid is 5000 by molecular weight cut-off, membrane area is the ultra-filtration membrane bag of the polyethers maple material of 50 square centimeters, filtration end obtains intracellular toxin lower than 0.05EU/ML, specific conductivity is 0.14 μ s/cm, D abundance is that the low deuterium of 1ppm washes target water.
Embodiment 7
Industrial low deuterium washes target water, D abundance is 1ppm, endotoxin content is 20EU/ML, specific conductivity is 4.5 μ s/cm, add the potassium metal that purity is 99.9%, be made into the potassium hydroxide solution of 0.5mol/L, the high-purity helium put into purity is 99.999% carries out single flash as protecting the distilled water generator of gas, then being put into by single flash liquid by purity is that high-purity helium of 99.999% is as the distilled water generator protecting gas, and add purity be 99.99% Vanadium Pentoxide in FLAKES be mixed with the phosphoric acid solution of 0.1mol/L, carry out second distillation, gained second distillation liquid is 5000 by molecular weight cut-off, membrane area is the ultra-filtration membrane bag of the polyethers maple material of 50 square centimeters, filtration end obtains intracellular toxin lower than 0.05EU/ML, specific conductivity is 0.17 μ s/cm, D abundance is that the low deuterium of 1ppm washes target water.
Above-mentioned is can understand and use invention for ease of those skilled in the art to the description of embodiment.Person skilled in the art obviously easily can make various amendment to these embodiments, and General Principle described herein is applied in other embodiments and need not through performing creative labour.Therefore, the invention is not restricted to above-described embodiment, those skilled in the art, according to announcement of the present invention, do not depart from improvement that scope makes and amendment all should within protection scope of the present invention.
Claims (10)
1. remove the method that low deuterium washes intracellular toxin and foreign ion in target water for one kind, it is characterized in that, first utilize two-step distillation to remove low deuterium and wash part intracellular toxin in target water coarse raw materials and foreign ion, then remove low deuterium through ultrafiltration membrance filter and wash remaining intracellular toxin in target water.
2. according to claim 1ly a kind ofly remove the method that low deuterium washes intracellular toxin and foreign ion in target water, it is characterized in that, the method comprises the following steps:
(1) first time distillation:
Low deuterium is washed in target water raw material and adds alkaline hydrated oxide, basic oxide or high activity alkali metal, be mixed with strong base solution, put into water distilling apparatus and distill, obtain single flash liquid,
(2) second time distillation:
Single flash liquid is put into water distilling apparatus, and adds Vanadium Pentoxide in FLAKES and be mixed with phosphoric acid solution, distill, obtain second distillation liquid;
(3) ultrafiltration membrance filter:
Adopt ultra-filtration membrane to filter second distillation liquid, filtration end obtains the qualified product that D abundance does not raise, endotoxin content is up to standard, specific conductivity is qualified.
3. according to claim 2ly a kind ofly remove the method that low deuterium washes intracellular toxin and foreign ion in target water, it is characterized in that, the alkaline hydrated oxide, basic oxide or the high activity alkali metal that add in step (1) are analytical pure and above purity, and after dissolving, the massfraction of gained strong base solution is not more than 1mol/L.
4. according to claim 2ly a kind ofly remove the method that low deuterium washes intracellular toxin and foreign ion in target water, it is characterized in that, alkaline hydrated oxide described in step (1) comprises sodium hydroxide, potassium hydroxide or calcium hydroxide, described basic oxide comprise sodium oxide and potassium oxide, and described high activity alkali metal comprises potassium or sodium.
5. according to claim 2ly a kind ofly remove the method that low deuterium washes intracellular toxin and foreign ion in target water, it is characterized in that, in step (2), Vanadium Pentoxide in FLAKES used is analytical pure and above purity, and the concentration of phosphoric acid solution is 0.1mol/L-5mol/L.
6. according to claim 2ly a kind ofly remove the method that low deuterium washes intracellular toxin and foreign ion in target water, it is characterized in that, water distilling apparatus used in step (1) and step (2) is Rotary Evaporators or distilled water generator.
7. according to claim 2ly a kind ofly remove the method that low deuterium washes intracellular toxin and foreign ion in target water; it is characterized in that, the still-process in step (1) and step (2) is that nitrogen, argon gas or the helium being greater than more than 99.99% in purity carries out as protecting in the environment of gas.
8. according to claim 2ly a kind ofly remove the method that low deuterium washes intracellular toxin and foreign ion in target water, it is characterized in that, in step (3), the molecular weight cut-off of ultra-filtration membrane used is equal to or less than 10KD.
9. according to claim 2ly a kind ofly remove the method that low deuterium washes intracellular toxin and foreign ion in target water, it is characterized in that, in step (3), ultra-filtration membrane material used is polyethersulfone or composite regenerated Mierocrystalline cellulose.
10. according to claim 2ly a kind ofly remove the method that low deuterium washes intracellular toxin and foreign ion in target water, it is characterized in that, the abundance scope that the low deuterium described in step (1) washes the deuterium of target water raw material is 1ppm to 149ppm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510615563.6A CN105130083B (en) | 2015-09-24 | 2015-09-24 | It is a kind of to remove the method that low deuterium washes endotoxin and foreign ion in target water |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510615563.6A CN105130083B (en) | 2015-09-24 | 2015-09-24 | It is a kind of to remove the method that low deuterium washes endotoxin and foreign ion in target water |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105130083A true CN105130083A (en) | 2015-12-09 |
| CN105130083B CN105130083B (en) | 2017-04-05 |
Family
ID=54715741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510615563.6A Active CN105130083B (en) | 2015-09-24 | 2015-09-24 | It is a kind of to remove the method that low deuterium washes endotoxin and foreign ion in target water |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105130083B (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050084874A1 (en) * | 2003-04-22 | 2005-04-21 | Georges Belfort | Microfiltration and/or ultrafiltration process for recovery of target molecules from polydisperse liquids |
| CN1923715A (en) * | 2005-09-01 | 2007-03-07 | 上海化工研究院 | Purifying method of removing bacteria and organic compound in heavy oxygen water |
| CN101858895A (en) * | 2010-05-18 | 2010-10-13 | 上海化工研究院 | Method for detecting deuterium content in deuterium depleted water |
| CN102398894A (en) * | 2010-09-07 | 2012-04-04 | 廖文加 | Preparation of deuterium-depleted water, and application thereof |
| CN203922779U (en) * | 2014-03-21 | 2014-11-05 | 江苏正帆华东净化设备有限公司 | Multi-effect water distillator residual liquid discharge device |
-
2015
- 2015-09-24 CN CN201510615563.6A patent/CN105130083B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050084874A1 (en) * | 2003-04-22 | 2005-04-21 | Georges Belfort | Microfiltration and/or ultrafiltration process for recovery of target molecules from polydisperse liquids |
| CN1923715A (en) * | 2005-09-01 | 2007-03-07 | 上海化工研究院 | Purifying method of removing bacteria and organic compound in heavy oxygen water |
| CN101858895A (en) * | 2010-05-18 | 2010-10-13 | 上海化工研究院 | Method for detecting deuterium content in deuterium depleted water |
| CN102398894A (en) * | 2010-09-07 | 2012-04-04 | 廖文加 | Preparation of deuterium-depleted water, and application thereof |
| CN203922779U (en) * | 2014-03-21 | 2014-11-05 | 江苏正帆华东净化设备有限公司 | Multi-effect water distillator residual liquid discharge device |
Non-Patent Citations (2)
| Title |
|---|
| 刘严等: "PCA-BP在18O级联精馏塔中的应用", 《广东化工》 * |
| 张丽雅等: "同位素水精馏非稳态过程制备低氘水的研究与应用", 《化学世界》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105130083B (en) | 2017-04-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103877953B (en) | A kind of hydrogel for sewage disposal and preparation method thereof | |
| CN105658326B (en) | For the regeneration method of the waste phosphoric acid zirconium of reuse in sorbent processing | |
| CN106984290A (en) | The preparation method of the chitosan of adsorbing heavy metal ions/sodium alginate magnetic composite microsphere | |
| CN105536726A (en) | Preparation method of oxidized graphene and sodium alginate composite absorbing material capable of removing ciprofloxacin in aqueous solution | |
| CN106818752B (en) | A kind of preparation method of high-content kasugarnycin aqua | |
| CN103357375B (en) | Magnetic mesoporous silica adsorbent for removing organic pollutants in water body and preparation method and application thereof | |
| CN104921241A (en) | Production technology of mineral water | |
| CN110203994A (en) | Utilize the method for multi-layer hole charcoal activation persulfate degradable organic pollutant | |
| CN108996598A (en) | A kind of FLUORIDE REMOVAL IN WASTEWATER application of difunctional metal chelate resin sorbent | |
| Butt et al. | Lithium harvesting from the most abundant primary and secondary sources: A comparative study on conventional and membrane technologies | |
| CN100581637C (en) | Filtering medium used for eliminating haloacetic acids in water and preparation method thereof | |
| KR101055395B1 (en) | Method for recovering high purity potassium iodide and borides from aqueous waste from polarizing film manufacturing process | |
| CN110711502A (en) | High-selectivity separation membrane based on rubidium and separation and enrichment method thereof | |
| CN108970589A (en) | A kind of hydrotalcite plural gel ball and its preparation method and application | |
| CN105130083A (en) | Method for removing endotoxin and foreign ions in low-deuterium target washing water | |
| CN206570148U (en) | A kind of integrated combination purifier | |
| CN103071456B (en) | Organic amine iodine ion adsorbent as well as preparation method and application thereof | |
| CN108569712A (en) | Preparation method of tetragonal body shape magnesium oxide material and products thereof and application | |
| KR20130114230A (en) | High stable non-ionic n-vinyl butyrolactam iodine solution and preparation method thereof | |
| CN102698703B (en) | Method for preparing arsenic adsorbent and method for treating waste water | |
| CN112876682B (en) | Quaternary ammonium salt polysulfone antibacterial liquid, preparation method and application thereof | |
| CN100417601C (en) | Purifying method of removing bacteria and organic compound in heavy oxygen water | |
| CN112844333B (en) | Preparation method of organic phosphine doped polyvinyl alcohol chitosan composite sphere | |
| CN205773787U (en) | A kind of water treatment facilities | |
| CN104397027B (en) | Bacteriostatic agent and preparation method thereof and purifier |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 200062 Shanghai city Putuo District Yunling Road No. 345 Patentee after: Shanghai Chemical Research Institute Co., Ltd. Patentee after: Shanghai Lianhong Isotope Technology Co., Ltd. Address before: 200062 Shanghai city Putuo District Yunling Road No. 345 Patentee before: Shanghai Research Institute of Chemical Industry Patentee before: Shanghai Lianhong Isotope Technology Co., Ltd. |