CN105126212A - Adjustable atomization circuit and control method - Google Patents

Adjustable atomization circuit and control method Download PDF

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CN105126212A
CN105126212A CN201510656452.XA CN201510656452A CN105126212A CN 105126212 A CN105126212 A CN 105126212A CN 201510656452 A CN201510656452 A CN 201510656452A CN 105126212 A CN105126212 A CN 105126212A
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atomization
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CN105126212B (en
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王天星
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Zhejiang E Linkcare Medical Technology Co ltd
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Abstract

本发明公开了一种可调节式雾化电路及控制方法,其电路包括微控制器单元、可调升压单元和超声雾化单元,所述微控制器单元分别连接到可调升压单元和超声雾化单元,所述可调升压单元与所述超声雾化单元连接。微控制单元控制可调升压单元和超声雾化单元的工作状态,调节超声震动频率和幅度,从而实现对雾化速率的调整。本发明可以根据不同药物特性调节最佳雾化速率,使雾滴更加细小均匀,更有利于人体肺部吸收,也可以根据病人的年龄和身体状态,调节合适的雾化速率,提高雾化治疗的舒适度。本方案适用于药物雾化治疗领域。

The invention discloses an adjustable atomization circuit and a control method, the circuit includes a microcontroller unit, an adjustable boost unit and an ultrasonic atomization unit, and the microcontroller unit is connected to the adjustable boost unit and the ultrasonic atomization unit respectively. An ultrasonic atomization unit, the adjustable boost unit is connected with the ultrasonic atomization unit. The micro-control unit controls the working state of the adjustable booster unit and the ultrasonic atomization unit, and adjusts the frequency and amplitude of ultrasonic vibration, thereby realizing the adjustment of the atomization rate. The present invention can adjust the optimal atomization rate according to different drug properties, making the droplets finer and more uniform, which is more conducive to the absorption of the human lungs, and can also adjust the appropriate atomization rate according to the patient's age and physical condition to improve the atomization treatment. of comfort. This solution is suitable for the field of medicine atomization treatment.

Description

一种可调节式雾化电路及控制方法An adjustable atomization circuit and its control method

技术领域 technical field

本发明涉及医疗设备领域,尤其是涉及一种可调节式雾化电路及控制方法。 The invention relates to the field of medical equipment, in particular to an adjustable atomization circuit and a control method.

背景技术 Background technique

雾化吸入治疗可使药物直接作用于病变部位,与口服法相比,具有用药剂量小、见效快、副作用少、使用方便、疗效显著等优点;而且呼吸道局部药物浓度高,可避免或减少全身使用激素。因此,雾化吸入疗法是治疗呼吸系统疾病一种理想的给药途径,目前已经被广泛采用。 Aerosol inhalation therapy can make the drug directly act on the lesion. Compared with the oral method, it has the advantages of small dosage, quick effect, less side effects, convenient use, and significant curative effect; and the local drug concentration in the respiratory tract is high, which can avoid or reduce systemic use. hormone. Therefore, aerosol inhalation therapy is an ideal route of administration for the treatment of respiratory diseases, and has been widely used at present.

当然,雾化吸入治疗也需要注意控制一些细节,如果使用不当,也可导致不良后果。其中一项是应正确进行雾化量的控制。 Of course, aerosol inhalation treatment also needs to pay attention to control some details, if used improperly, it can also lead to adverse consequences. One of them is that the amount of atomization should be controlled correctly.

但是,目前市场现有的医用雾化器都不具备雾化速率可调的功能,因此对于需要控制雾化量的病人,需要医护人员人工控制,操作非常不便,且风险很大。 However, the current medical nebulizers in the market do not have the function of adjusting the nebulization rate. Therefore, for patients who need to control the nebulization volume, manual control by medical staff is required, which is very inconvenient and risky to operate.

中华人民共和国国家知识产权局于2005年08月10日公开了名称为“医用高压氧舱用药物雾化装置”的专利文献(公开号:CN2715776),其包括有药物雾化罐,药物雾化罐设置在医用高压氧舱的内部,药物雾化罐的下部盛有药液,提供雾化动力氧气的供氧管插入药物雾化罐内的药液中,药液通过吸管接至药物雾化罐上腔室内的雾化喷头,上腔室连通药物管路,药物管路与吸氧管路并接后接至吸氧面罩。此方案也并未公开能够调整雾化速率的相关方案。 The State Intellectual Property Office of the People's Republic of China published a patent document titled "Drug Atomization Device for Medical Hyperbaric Oxygen Chamber" on August 10, 2005 (publication number: CN2715776), which includes drug atomization tanks, drug atomization The tank is set inside the medical hyperbaric oxygen chamber, and the lower part of the drug atomization tank contains the liquid medicine. The oxygen supply tube that provides atomization power oxygen is inserted into the medicine liquid in the medicine atomization tank, and the medicine liquid is connected to the medicine atomizer through the straw. The atomizing nozzle in the upper chamber of the tank, the upper chamber is connected with the medicine pipeline, and the medicine pipeline and the oxygen inhalation pipeline are connected in parallel and then connected to the oxygen inhalation mask. This solution also does not disclose a related solution capable of adjusting the atomization rate.

发明内容 Contents of the invention

本发明主要是解决现有技术所存在的雾化速率不可调、操作不便、风险大等的技术问题,提供一种可以调整雾化速率、便于医护人员控制的可调节式雾化电路及控制方法。 The present invention mainly solves the technical problems of non-adjustable atomization rate, inconvenient operation and high risk in the prior art, and provides an adjustable atomization circuit and control method that can adjust the atomization rate and is convenient for medical staff to control. .

本发明针对上述技术问题主要是通过下述技术方案得以解决的:一种可调节式雾化电路,包括微控制器单元、可调升压单元和超声雾化单元,所述微控制器单元分别连接到可调升压单元和超声雾化单元,所述可调升压单元与所述超声雾化单元连接。 The present invention mainly solves the above-mentioned technical problems through the following technical solutions: an adjustable atomization circuit, including a micro-controller unit, an adjustable boost unit and an ultrasonic atomization unit, and the micro-controller unit is respectively It is connected to an adjustable boost unit and an ultrasonic atomization unit, and the adjustable boost unit is connected to the ultrasonic atomization unit.

微控制单元控制可调升压单元和超声雾化单元的工作状态,调节超声震动频率和幅度,从而实现对雾化速率的调整。 The micro-control unit controls the working state of the adjustable booster unit and the ultrasonic atomization unit, and adjusts the frequency and amplitude of ultrasonic vibration, thereby realizing the adjustment of the atomization rate.

作为优选,所述超声雾化单元包括超声信号源发生电路和雾化晶片,所述超声信号源发生电路包括电阻R7、电阻R8、电容C2、电容C4、电感L2和MOS管Q1,所述电感L2的第一端连接电源+VP,第二端连接MOS管Q1的漏极,MOS管Q1的源极通过电阻R8接地,MOS管Q1的栅极通过电阻R7连接微控制器单元,电容C2和电容C4串联以后并联在电感L2的两端,雾化晶片与电感L2并联。 Preferably, the ultrasonic atomization unit includes an ultrasonic signal source generating circuit and an atomized wafer, the ultrasonic signal source generating circuit includes a resistor R7, a resistor R8, a capacitor C2, a capacitor C4, an inductor L2 and a MOS transistor Q1, and the inductor The first end of L2 is connected to the power supply +VP, the second end is connected to the drain of MOS transistor Q1, the source of MOS transistor Q1 is grounded through resistor R8, the gate of MOS transistor Q1 is connected to the microcontroller unit through resistor R7, capacitor C2 and The capacitor C4 is connected in parallel with both ends of the inductor L2 after being connected in series, and the atomized chip is connected in parallel with the inductor L2.

超声雾化单元把超声信号源的电能转换成雾化晶片机械谐振,使液体通过雾化晶片上的微孔网筛后形成喷雾滴。 The ultrasonic atomization unit converts the electrical energy of the ultrasonic signal source into the mechanical resonance of the atomized chip, and makes the liquid pass through the microporous mesh screen on the atomized chip to form spray droplets.

作为优选,所述可调升压单元包括升压转换器U1、电容C1、电容C3、电感L1、电阻R1、电阻R2、电阻R3、电阻R4、电阻R5、电阻R6、二极管D1、MOS管Q2和MOS管Q3;所述升压转换器U1的4脚和5脚连接输入电源+VIN,2脚接地,电容C3的第一端连接升压转换器U1的5脚,另一端接地;二极管D1的正极连接升压转换器U1的1脚,负极通过电容C1接地;电阻R1的第一端连接二极管D1的负极,第二端连接升压转换器U1的3脚;电阻R2的第一端连接升压转换器U1的3脚,第二端接地;电阻R3的第一端连接升压转换器U1的3脚,第二端连接MOS管Q2的漏极;电阻R4的第一端连接升压转换器U1的3脚,第二端连接MOS管Q3的漏极;MOS管Q2的栅极通过电阻R5连接微控制器单元,源极接地;MOS管Q3的栅极通过电阻R6连接微控制器单元,源极接地;电感L1跨接在升压转换器U1的1脚和5脚之间;二极管D1的负极为电源+VP端;二极管D1为肖特基二极管。 Preferably, the adjustable boost unit includes a boost converter U1, a capacitor C1, a capacitor C3, an inductor L1, a resistor R1, a resistor R2, a resistor R3, a resistor R4, a resistor R5, a resistor R6, a diode D1, and a MOS transistor Q2 and MOS tube Q3; pin 4 and pin 5 of the boost converter U1 are connected to the input power +VIN, pin 2 is grounded, the first end of capacitor C3 is connected to pin 5 of the boost converter U1, and the other end is grounded; diode D1 The anode of the resistor R1 is connected to pin 1 of the boost converter U1, and the cathode is grounded through the capacitor C1; the first end of the resistor R1 is connected to the cathode of the diode D1, and the second end is connected to the pin 3 of the boost converter U1; the first end of the resistor R2 is connected to Pin 3 of the boost converter U1, the second end is grounded; the first end of the resistor R3 is connected to pin 3 of the boost converter U1, and the second end is connected to the drain of the MOS transistor Q2; the first end of the resistor R4 is connected to the boost Pin 3 of the converter U1, the second end is connected to the drain of the MOS transistor Q3; the gate of the MOS transistor Q2 is connected to the microcontroller unit through the resistor R5, and the source is grounded; the gate of the MOS transistor Q3 is connected to the microcontroller through the resistor R6 unit, the source is grounded; the inductor L1 is connected between pin 1 and pin 5 of the boost converter U1; the cathode of the diode D1 is the power supply +VP terminal; the diode D1 is a Schottky diode.

U1是固定频率的升压转换器,通过反馈引脚3与内部基准电压比较调节输出电压,当输出反馈电压大于内部基准电压时,减小开关调制脉冲占空比,使输出电压变小,当反馈电压小于内部基准电压时,增大开关调制脉冲占空比,使输出电压变大,最终使输出稳压。当微控制器单元与电阻R5和R6连接的端口都输出低电平时,N沟道MOS管Q2和Q3都不导通,由于U1的反馈引脚3脚为误差放大器输入脚,有非常高的输入阻抗,输入电流可以忽略,因此流过R1和R2的电流I相等,I等于U1内部基准电压VREF除以R1,那么可以计算输出电压+VP=I×(R1+R2),I用VREF/R2代入化简可以得到:+VP=VREF×(1+R1/R2),当微控制单元与电阻R5连接的端口输出高电平时,N沟道MOS管Q2导通,此时R2变成与R3并联,阻值变小,从计算公式可以推出+VP变大,同理当微控制单元与电阻R6连接的端口也输出高电平时,R2变成与R3和R4并联,阻值进一步变小,从而+VP进一步变大,通过微控制单元与电阻R5和R6连接的端口的控制可以调节+VP输出电压为低、中、高三档。当微控制单元与电阻R7连接的端口输出高电平时,N沟道MOS管Q1导通,+VP流过电感L2的电流逐渐上升,电感蓄能,当微控制单元与电阻R7连接的端口输出低电平时,N沟道MOS管Q1截至,电感L2通过雾化片续流,电压施加到雾化器两端,驱动雾化片振动,L2能量通过雾化片释放,控制微控制单元与电阻R7连接的端口输出的PWM频率可以调节雾化片驱动信号频率,当驱动信号频率与雾化片的特性频率一致时,电流最大,雾化量也最大。同时通过控制微控制单元与电阻R5和R6连接的端口调节+VP输出电压,可以调节施加到雾化片两端的电压峰值,使流过雾化片的峰值电流变化,从而调节雾化片的振动幅度,改变雾化速率。 U1 is a fixed-frequency boost converter. It adjusts the output voltage by comparing the feedback pin 3 with the internal reference voltage. When the output feedback voltage is greater than the internal reference voltage, it reduces the switching modulation pulse duty cycle to make the output voltage smaller. When When the feedback voltage is lower than the internal reference voltage, the duty cycle of the switch modulation pulse is increased to increase the output voltage and finally stabilize the output voltage. When the ports connected to the microcontroller unit and the resistors R5 and R6 both output low levels, the N-channel MOS transistors Q2 and Q3 are not turned on. Since the feedback pin 3 of U1 is the input pin of the error amplifier, there is a very high The input impedance and input current can be ignored, so the current I flowing through R1 and R2 is equal, and I is equal to the internal reference voltage VREF of U1 divided by R1, then the output voltage +VP=I×(R1+R2) can be calculated, and I can be calculated by VREF/ Substituting R2 into the simplification can get: +VP=VREF×(1+R1/R2), when the port connected to the micro-control unit and resistor R5 outputs a high level, the N-channel MOS transistor Q2 is turned on, and R2 becomes the same as R3 is connected in parallel, and the resistance becomes smaller. From the calculation formula, it can be deduced that +VP becomes larger. Similarly, when the port connected to the micro-control unit and resistor R6 also outputs a high level, R2 becomes parallel with R3 and R4, and the resistance further becomes smaller. As a result, +VP is further increased, and the output voltage of +VP can be adjusted to low, medium and high levels through the control of the ports connected to the micro-control unit and resistors R5 and R6. When the port connected to the micro-control unit and the resistor R7 outputs a high level, the N-channel MOS transistor Q1 is turned on, and the current of +VP flowing through the inductor L2 gradually rises, and the inductor stores energy. When the port connected to the micro-control unit and the resistor R7 outputs When the level is low, the N-channel MOS transistor Q1 is turned off, the inductor L2 continues to flow through the atomizer, the voltage is applied to both ends of the atomizer, and the atomizer is driven to vibrate, and the energy of L2 is released through the atomizer to control the micro control unit and the resistor The PWM frequency output from the port connected to R7 can adjust the driving signal frequency of the atomizing sheet. When the driving signal frequency is consistent with the characteristic frequency of the atomizing sheet, the current is the largest and the amount of atomization is also the largest. At the same time, the +VP output voltage can be adjusted by controlling the ports connected to the micro-control unit and resistors R5 and R6, which can adjust the peak voltage applied to both ends of the atomizer, so that the peak current flowing through the atomizer can be changed, thereby adjusting the vibration of the atomizer Amplitude, changes the atomization rate.

一种可调节式雾化电路控制方法,基于前述的可调节式雾化电路,包括以下步骤: An adjustable atomization circuit control method, based on the aforementioned adjustable atomization circuit, includes the following steps:

A、输入患者年龄; A. Enter the age of the patient;

B、输入患者病症; B. Enter the patient's disease;

C、微控制单元根据患者年龄和病症选择合适的雾化量和雾化方式。 C. The micro-control unit selects the appropriate atomization amount and atomization method according to the patient's age and symptoms.

不同情况下需要有不同的雾化量和雾化方式。如幼儿喉部组织发育不完善,喉腔及鼻毛缓冲作用小,大量雾化吸入容易导致缺氧,因此幼儿进行雾化吸入治疗时雾化量不易过大。另外,对于慢性阻塞性肺气肿的病人,雾化时应采用渐进式调节雾化量的吸入方法,即从小雾量、低浓度开始,等气道适应后,再逐渐增加雾化量,且每次吸入时间不超过10分钟;因为这类病人多为老年人,呼吸道适应能力差,肺通气和换气功能障碍,若一开始雾化量就很大,大量冷空气进入气道,可能导致支气管痉挛,导致憋气,呼吸困难。还有,不同药物因其不同特点,也对雾化量的有不同的要求。 Different situations require different atomization volumes and atomization methods. For example, if the throat tissue of young children is not fully developed, and the buffering effect of the throat cavity and nose hair is small, a large amount of nebulized inhalation may easily lead to hypoxia. In addition, for patients with chronic obstructive emphysema, the inhalation method of gradually adjusting the amount of nebulization should be adopted during nebulization, that is, start with a small amount of nebulization and a low concentration, and then gradually increase the amount of nebulization after the airway adapts, and Each inhalation time should not exceed 10 minutes; because most of these patients are elderly people with poor respiratory adaptability, pulmonary ventilation and ventilation dysfunction, if the amount of atomization is large at the beginning, a large amount of cold air enters the airway, which may cause Bronchospasm, causing breathlessness and difficulty breathing. In addition, different drugs have different requirements on the amount of atomization due to their different characteristics.

本发明带来的实质性效果是,可以进行雾化速率的分档精确调节,从而实现雾化量的精确调节;另外该电路也可配合软件系统,可对雾化速率进行编程控制,实现自动调节。医护人员可以根据病人和药物的实际要求,选择合适的雾化速率进行雾化资料,一方面能使病人得到更加适合、更加精准的治疗,减少风险;另一方面大大降低医护人员操作的复杂性,减少人工风险,提高效率和医护质量。 The substantive effect brought by the invention is that the atomization rate can be precisely adjusted in stages, thereby realizing the precise adjustment of the atomization amount; in addition, the circuit can also cooperate with the software system to program and control the atomization rate to realize automatic adjust. According to the actual requirements of patients and drugs, medical staff can choose the appropriate atomization rate for nebulization data. On the one hand, it can enable patients to receive more suitable and precise treatment and reduce risks; on the other hand, it can greatly reduce the complexity of medical staff's operation. , reduce manual risks, improve efficiency and quality of medical care.

附图说明 Description of drawings

图1是本发明的一种系统框图; Fig. 1 is a kind of system block diagram of the present invention;

图2是本发明的一种电路图; Fig. 2 is a kind of circuit diagram of the present invention;

图中:1、微控制单元,2、可调升压单元,3、超声雾化单元。 In the figure: 1. Micro control unit, 2. Adjustable boost unit, 3. Ultrasonic atomization unit.

具体实施方式 detailed description

下面通过实施例,并结合附图,对本发明的技术方案作进一步具体的说明。 The technical solutions of the present invention will be further specifically described below through the embodiments and in conjunction with the accompanying drawings.

实施例:本实施例的一种可调节式雾化电路,如图1所示,包括微控制器单元1、可调升压单元2和超声雾化单元3,微控制器单元分别连接到可调升压单元和超声雾化单元,所述可调升压单元与所述超声雾化单元连接。 Embodiment: An adjustable atomization circuit of this embodiment, as shown in Figure 1, includes a microcontroller unit 1, an adjustable boost unit 2 and an ultrasonic atomization unit 3, and the microcontroller unit is connected to Adjust the boost unit and the ultrasonic atomization unit, the adjustable boost unit is connected with the ultrasonic atomization unit.

如图2所示,超声雾化单元包括超声信号源发生电路和雾化晶片,所述超声信号源发生电路包括电阻R7、电阻R8、电容C2、电容C4、电感L2和MOS管Q1,所述电感L2的第一端连接电源+VP,第二端连接MOS管Q1的漏极,MOS管Q1的源极通过电阻R8接地,MOS管Q1的栅极通过电阻R7连接微控制器单元,电容C2和电容C4串联以后并联在电感L2的两端,雾化晶片与电感L2并联。可调升压单元包括升压转换器U1、电容C1、电容C3、电感L1、电阻R1、电阻R2、电阻R3、电阻R4、电阻R5、电阻R6、二极管D1、MOS管Q2和MOS管Q3;所述升压转换器U1的4脚和5脚连接输入电源+VIN,2脚接地,电容C3的第一端连接升压转换器U1的5脚,另一端接地;二极管D1的正极连接升压转换器U1的1脚,负极通过电容C1接地;电阻R1的第一端连接二极管D1的负极,第二端连接升压转换器U1的3脚;电阻R2的第一端连接升压转换器U1的3脚,第二端接地;电阻R3的第一端连接升压转换器U1的3脚,第二端连接MOS管Q2的漏极;电阻R4的第一端连接升压转换器U1的3脚,第二端连接MOS管Q3的漏极;MOS管Q2的栅极通过电阻R5连接微控制器单元,源极接地;MOS管Q3的栅极通过电阻R6连接微控制器单元,源极接地;电感L1跨接在升压转换器U1的1脚和5脚之间;二极管D1的负极为电源+VP端;二极管D1为肖特基二极管。 As shown in Figure 2, the ultrasonic atomization unit includes an ultrasonic signal source generating circuit and an atomized chip, and the ultrasonic signal source generating circuit includes a resistor R7, a resistor R8, a capacitor C2, a capacitor C4, an inductor L2 and a MOS transistor Q1. The first end of the inductor L2 is connected to the power supply +VP, the second end is connected to the drain of the MOS transistor Q1, the source of the MOS transistor Q1 is grounded through the resistor R8, the gate of the MOS transistor Q1 is connected to the microcontroller unit through the resistor R7, and the capacitor C2 After being connected in series with the capacitor C4, it is connected in parallel at both ends of the inductance L2, and the atomized chip is connected in parallel with the inductance L2. The adjustable boost unit includes a boost converter U1, capacitor C1, capacitor C3, inductor L1, resistor R1, resistor R2, resistor R3, resistor R4, resistor R5, resistor R6, diode D1, MOS transistor Q2 and MOS transistor Q3; Pin 4 and pin 5 of the boost converter U1 are connected to the input power supply +VIN, pin 2 is grounded, the first end of the capacitor C3 is connected to pin 5 of the boost converter U1, and the other end is grounded; the anode of the diode D1 is connected to the boost Pin 1 of converter U1, the negative pole is grounded through capacitor C1; the first end of resistor R1 is connected to the negative pole of diode D1, and the second end is connected to pin 3 of boost converter U1; the first end of resistor R2 is connected to boost converter U1 The first end of the resistor R3 is connected to the 3rd pin of the boost converter U1, and the second end is connected to the drain of the MOS transistor Q2; the first end of the resistor R4 is connected to the 3rd pin of the boost converter U1. pin, the second end is connected to the drain of MOS transistor Q3; the gate of MOS transistor Q2 is connected to the microcontroller unit through resistor R5, and the source is grounded; the gate of MOS transistor Q3 is connected to the microcontroller unit through resistor R6, and the source is grounded ; The inductance L1 is connected between pin 1 and pin 5 of the boost converter U1; the cathode of the diode D1 is the power supply +VP terminal; the diode D1 is a Schottky diode.

U1是固定频率的升压转换器,通过反馈引脚3与内部基准电压比较调节输出电压,当输出反馈电压大于内部基准电压时,减小开关调制脉冲占空比,使输出电压变小,当反馈电压小于内部基准电压时,增大开关调制脉冲占空比,使输出电压变大,最终使输出稳压。当GPIO0和GPIO1都输出低电平时,N沟道MOS管Q2和Q3都不导通,由于U1的反馈引脚3脚为误差放大器输入脚,有非常高的输入阻抗,输入电流可以忽略,因此流过R1和R2的电流I相等,I等于U1内部基准电压VREF除以R1,那么可以计算输出电压+VP=I×(R1+R2),I用VREF/R2代入化简可以得到:+VP=VREF×(1+R1/R2),当GPIO0输出高电平时,N沟道MOS管Q2导通,此时R2变成与R3并联,阻值变小,从计算公式可以推出+VP变大,同理当GPIO1也输出高电平时,R2变成与R3和R4并联,阻值进一步变小,从而+VP进一步变大,通过GPIO0和GPIO1的控制可以调节+VP输出电压为低、中、高三档。当GPIO2输出高电平时,N沟道MOS管Q1导通,+VP流过电感L2的电流逐渐上升,电感蓄能,当GPIO2输出低电平时,N沟道MOS管Q1截至,电感L2通过雾化片续流,电压施加到雾化器两端,驱动雾化片振动,L2能量通过雾化片释放,控制GPIO2输出的PWM频率可以调节雾化片驱动信号频率,当驱动信号频率与雾化片的特性频率一致时,电流最大,雾化量也最大。同时通过控制GPIO0和GPIO1调节+VP输出电压,可以调节施加到雾化片两端的电压峰值,使流过雾化片的峰值电流变化,从而调节雾化片的振动幅度,改变雾化速率。 U1 is a fixed-frequency boost converter. It adjusts the output voltage by comparing the feedback pin 3 with the internal reference voltage. When the output feedback voltage is greater than the internal reference voltage, it reduces the switching modulation pulse duty cycle to make the output voltage smaller. When When the feedback voltage is lower than the internal reference voltage, the duty cycle of the switch modulation pulse is increased to increase the output voltage and finally stabilize the output voltage. When both GPIO0 and GPIO1 output low level, the N-channel MOS transistors Q2 and Q3 are not turned on. Since the feedback pin 3 of U1 is the input pin of the error amplifier, it has a very high input impedance, and the input current can be ignored, so The current I flowing through R1 and R2 is equal, and I is equal to the internal reference voltage VREF of U1 divided by R1, then the output voltage +VP=I×(R1+R2) can be calculated, and I can be simplified by using VREF/R2 to get: +VP =VREF×(1+R1/R2), when GPIO0 outputs a high level, the N-channel MOS transistor Q2 is turned on, at this time R2 becomes parallel with R3, and the resistance becomes smaller. From the calculation formula, it can be deduced that +VP becomes larger Similarly, when GPIO1 also outputs a high level, R2 becomes parallel with R3 and R4, and the resistance value further decreases, so that +VP further increases. Through the control of GPIO0 and GPIO1, the +VP output voltage can be adjusted to low, medium and high. files. When GPIO2 outputs a high level, the N-channel MOS transistor Q1 is turned on, and the current of +VP flowing through the inductor L2 gradually rises, and the inductor stores energy. When the GPIO2 outputs a low level, the N-channel MOS transistor Q1 is turned off, and the inductor L2 passes through the fog Continuous flow of the atomizer, the voltage is applied to both ends of the atomizer to drive the atomizer to vibrate, and the L2 energy is released through the atomizer. Controlling the PWM frequency output by GPIO2 can adjust the drive signal frequency of the atomizer. When the drive signal frequency is consistent with the atomizer When the characteristic frequency of the sheet is consistent, the current is the largest and the amount of atomization is also the largest. At the same time, by controlling GPIO0 and GPIO1 to adjust the +VP output voltage, the peak voltage applied to both ends of the atomizer can be adjusted to change the peak current flowing through the atomizer, thereby adjusting the vibration amplitude of the atomizer and changing the atomization rate.

本实施例的一种可调节式雾化电路控制方法,包括以下步骤: An adjustable atomization circuit control method in this embodiment includes the following steps:

A、输入患者年龄; A. Enter the age of the patient;

B、输入患者病症; B. Enter the patient's disease;

C、微控制单元根据患者年龄和病症选择合适的雾化量和雾化方式。 C. The micro-control unit selects the appropriate atomization amount and atomization method according to the patient's age and symptoms.

步骤C具体为: Step C is specifically:

C1、判断患者年龄Y是否小于7周岁,如果是,则进入步骤C2,否则进入步骤C3; C1. Determine whether the patient's age Y is less than 7 years old, if yes, go to step C2, otherwise go to step C3;

C2、基准雾化量设置为Y×10%+30%,进入步骤C4; C2. The base atomization amount is set to Y×10%+30%, and enter step C4;

C3、基准雾化量设置为100%,进入步骤C4; C3. Set the base atomization amount to 100%, and proceed to step C4;

C4、判断患者病症是否为慢性阻塞肺气肿,如果是,则进入步骤C5;否则进入步骤C7; C4. Determine whether the patient's condition is chronic obstructive emphysema, if yes, then enter step C5; otherwise, enter step C7;

C5、采用渐进雾化方式,具体为:初始雾化量为10%,每隔20秒雾化量增大10%,直至雾化量达到基准雾化量,维持基准雾化量7分钟,停止雾化; C5. Adopt the progressive atomization method, specifically: the initial atomization amount is 10%, and the atomization amount increases by 10% every 20 seconds until the atomization amount reaches the baseline atomization amount, and the baseline atomization amount is maintained for 7 minutes, then stop Atomization;

C6、间隔5-10分钟后重复步骤C5,直至药物雾化完毕; C6. Repeat step C5 after an interval of 5-10 minutes until the drug is atomized;

C7、采用常规雾化方式,具体为:将雾化量直接调整至基准雾化量,直至药物雾化完毕。 C7. Adopt the conventional atomization method, specifically: directly adjust the atomization amount to the reference atomization amount until the drug atomization is completed.

本方案中,雾化量即为雾化速率,也即为雾化器最大雾化速率的比例数,例如当前雾化量为50%,即为当前雾化速率是最大雾化速率的50%。 In this solution, the atomization amount is the atomization rate, that is, the ratio of the maximum atomization rate of the nebulizer. For example, the current atomization amount is 50%, that is, the current atomization rate is 50% of the maximum atomization rate .

雾化量和雾化方式也可以考虑药物特性,对于部分药物,控制方法中还需要在步骤C5中包括以下步骤:输入药物种类,微控制单元从数据库中选择匹配的雾化量、雾化方式和修正量,如果雾化量和雾化方式不为空,则按照匹配到的雾化量和雾化方式对药物进行雾化,放弃依据年龄和病症得到的雾化量和雾化方式;如果雾化量和雾化方式为空,则根据修正量修正基准雾化量、初始雾化量、单次雾化时间、雾化间隔、雾化量增速等参数; The atomization amount and atomization method can also consider the characteristics of the drug. For some drugs, the control method also needs to include the following steps in step C5: input the type of drug, and the micro-control unit selects the matching atomization amount and atomization method from the database. and correction amount, if the atomization amount and atomization method are not empty, the drug will be atomized according to the matched atomization amount and atomization method, and the atomization amount and atomization method obtained according to age and disease will be discarded; if If the atomization amount and atomization method are empty, the parameters such as the reference atomization amount, initial atomization amount, single atomization time, atomization interval, and atomization amount growth rate are corrected according to the correction amount;

步骤C6中还需要包括以下步骤:输入药物种类,微控制单元从数据库中选择匹配的雾化量、雾化方式和修正量,如果雾化量和雾化方式不为空,则按照匹配到的雾化量和雾化方式对药物进行雾化,放弃依据年龄和病症得到的雾化量和雾化方式;如果雾化量和雾化方式为空,则根据修正量修正基准雾化量。 Step C6 also needs to include the following steps: input the type of medicine, the micro-control unit selects the matching atomization amount, atomization method and correction amount from the database, if the atomization amount and atomization method are not empty, then follow the matched The atomization amount and atomization method are used to atomize the medicine, and the atomization amount and atomization method obtained according to age and disease are discarded; if the atomization amount and atomization method are empty, the base atomization amount is corrected according to the correction amount.

本方案的雾化速率可调节电路使雾化器可以根据不同药物特性调节最佳雾化速率,使雾滴更加细小均匀,更有利于人体肺部吸收,也可以根据病人的年龄和身体状态,调节合适的雾化速率,提高雾化治疗的舒适度。 The atomization rate adjustable circuit of this program enables the nebulizer to adjust the optimal atomization rate according to the characteristics of different drugs, making the droplets smaller and more uniform, which is more conducive to the absorption of the human lungs. It can also be adjusted according to the age and physical condition of the patient. Adjust the appropriate atomization rate to improve the comfort of atomization therapy.

本文中所描述的具体实施例仅仅是对本发明精神作举例说明。本发明所属技术领域的技术人员可以对所描述的具体实施例做各种各样的修改或补充或采用类似的方式替代,但并不会偏离本发明的精神或者超越所附权利要求书所定义的范围。 The specific embodiments described herein are merely illustrative of the spirit of the invention. Those skilled in the art to which the present invention belongs can make various modifications or supplements to the described specific embodiments or adopt similar methods to replace them, but they will not deviate from the spirit of the present invention or go beyond the definition of the appended claims range.

尽管本文较多地使用了微控制单元、超声雾化单元、雾化量等术语,但并不排除使用其它术语的可能性。使用这些术语仅仅是为了更方便地描述和解释本发明的本质;把它们解释成任何一种附加的限制都是与本发明精神相违背的。 Although terms such as microcontroller unit, ultrasonic atomization unit, and atomization volume are frequently used in this paper, the possibility of using other terms is not excluded. These terms are used only for the purpose of describing and explaining the essence of the present invention more conveniently; interpreting them as any kind of additional limitation is against the spirit of the present invention.

Claims (4)

1.一种可调节式雾化电路,其特征在于,包括微控制器单元、可调升压单元和超声雾化单元,所述微控制器单元分别连接到可调升压单元和超声雾化单元,所述可调升压单元与所述超声雾化单元连接。 1. An adjustable atomization circuit, characterized in that it comprises a microcontroller unit, an adjustable boost unit and an ultrasonic atomization unit, and the microcontroller unit is connected to the adjustable boost unit and the ultrasonic atomization unit respectively unit, and the adjustable boost unit is connected to the ultrasonic atomization unit. 2.根据权利要求1所述的一种可调节式雾化电路,其特征在于,所述超声雾化单元包括超声信号源发生电路和雾化晶片,所述超声信号源发生电路包括电阻R7、电阻R8、电容C2、电容C4、电感L2和MOS管Q1,所述电感L2的第一端连接电源+VP,第二端连接MOS管Q1的漏极,MOS管Q1的源极通过电阻R8接地,MOS管Q1的栅极通过电阻R7连接微控制器单元,电容C2和电容C4串联以后并联在电感L2的两端,雾化晶片与电感L2并联。 2. An adjustable atomization circuit according to claim 1, wherein the ultrasonic atomization unit includes an ultrasonic signal source generating circuit and an atomized chip, and the ultrasonic signal source generating circuit includes a resistor R7, Resistor R8, capacitor C2, capacitor C4, inductor L2 and MOS transistor Q1, the first end of the inductor L2 is connected to the power supply +VP, the second end is connected to the drain of the MOS transistor Q1, and the source of the MOS transistor Q1 is grounded through the resistor R8 , the gate of the MOS transistor Q1 is connected to the microcontroller unit through the resistor R7, the capacitor C2 and the capacitor C4 are connected in parallel to both ends of the inductor L2 after being connected in series, and the atomized chip is connected in parallel to the inductor L2. 3.根据权利要求1或2所述的一种可调节式雾化电路,其特征在于,所述可调升压单元包括升压转换器U1、电容C1、电容C3、电感L1、电阻R1、电阻R2、电阻R3、电阻R4、电阻R5、电阻R6、二极管D1、MOS管Q2和MOS管Q3;所述升压转换器U1的4脚和5脚连接输入电源+VIN,2脚接地,电容C3的一端连接升压转换器U1的5脚,另一端接地;二极管D1的正极连接升压转换器U1的1脚,负极通过电容C1接地;电阻R1的第一端连接二极管D1的负极,第二端连接升压转换器U1的3脚;电阻R2的第一端连接升压转换器U1的3脚,第二端接地;电阻R3的第一端连接升压转换器U1的3脚,第二端连接MOS管Q2的漏极;电阻R4的第一端连接升压转换器U1的3脚,第二端连接MOS管Q3的漏极;MOS管Q2的栅极通过电阻R5连接微控制器单元,源极接地;MOS管Q3的栅极通过电阻R6连接微控制器单元,源极接地;电感L1跨接在升压转换器U1的1脚和5脚之间;二极管D1的负极为电源+VP端;二极管D1为肖特基二极管。 3. An adjustable atomization circuit according to claim 1 or 2, characterized in that the adjustable boost unit includes a boost converter U1, a capacitor C1, a capacitor C3, an inductor L1, a resistor R1, Resistor R2, resistor R3, resistor R4, resistor R5, resistor R6, diode D1, MOS transistor Q2 and MOS transistor Q3; pin 4 and pin 5 of the boost converter U1 are connected to the input power supply +VIN, pin 2 is grounded, and the capacitor One end of C3 is connected to pin 5 of the boost converter U1, and the other end is grounded; the anode of the diode D1 is connected to pin 1 of the boost converter U1, and the negative pole is grounded through the capacitor C1; the first end of the resistor R1 is connected to the negative pole of the diode D1. The two ends are connected to pin 3 of boost converter U1; the first end of resistor R2 is connected to pin 3 of boost converter U1, and the second end is grounded; the first end of resistor R3 is connected to pin 3 of boost converter U1, and the first end of resistor R3 is connected to pin 3 of boost converter U1. The two ends are connected to the drain of the MOS transistor Q2; the first end of the resistor R4 is connected to the pin 3 of the boost converter U1, and the second end is connected to the drain of the MOS transistor Q3; the gate of the MOS transistor Q2 is connected to the microcontroller through the resistor R5 Unit, the source is grounded; the gate of the MOS transistor Q3 is connected to the microcontroller unit through the resistor R6, and the source is grounded; the inductor L1 is connected between pin 1 and pin 5 of the boost converter U1; the cathode of the diode D1 is the power supply +VP terminal; diode D1 is a Schottky diode. 4.一种可调节式雾化电路控制方法,基于权利要求1或2或3所述的可调节式雾化电路,其特征在于,包括以下步骤: 4. An adjustable atomization circuit control method, based on the adjustable atomization circuit according to claim 1, 2 or 3, characterized in that it comprises the following steps: A、输入患者年龄; A. Enter the age of the patient; B、输入患者病症; B. Enter the patient's disease; C、微控制单元根据患者年龄和病症选择合适的雾化量和雾化方式。 C. The micro-control unit selects the appropriate atomization amount and atomization method according to the patient's age and symptoms.
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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108355210A (en) * 2018-02-27 2018-08-03 华健 Variable-frequency and variable-voltage atomizer
CN108815654A (en) * 2018-04-24 2018-11-16 张莹 A kind of novel Respiratory Medicine atomization oxygenerator
CN109150159A (en) * 2018-10-08 2019-01-04 广州厚达电子科技有限公司 The ultrasonic ultrasonic delay line memory driving circuit and driving method of Low-voltage Low-power
CN109127257A (en) * 2018-10-29 2019-01-04 无锡中微爱芯电子有限公司 A kind of atomizer dedicated control circuit
WO2019165663A1 (en) * 2018-02-27 2019-09-06 华健 Atomizer having variable frequency and variable voltage
CN110243433A (en) * 2019-05-21 2019-09-17 广州畅呼医疗器械有限公司 A kind of water shortage detection system, method and the atomizer of atomizer
CN113813478A (en) * 2021-10-11 2021-12-21 河南省儿童医院郑州儿童医院 Automatic control method and system for drug delivery of atomizer
EP3782681A4 (en) * 2018-04-20 2022-01-12 Sunshine Lake Pharma Co., Ltd. Atomization apparatus and quick atomization method
CN113976380A (en) * 2021-10-27 2022-01-28 深圳宇凡微电子有限公司 Method for driving atomization sheet to work by self-made high-frequency pwm signal of single chip microcomputer

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2868444Y (en) * 2005-09-03 2007-02-14 熊武军 Low-pressure driving piezoelectric ceramic atomising-piece atomiser
US7673812B2 (en) * 2007-01-24 2010-03-09 Taidoc Technology Corporation Ultrasonic nebulizer apparatus and method for adjusting an operation frequency and checking an operating state thereof
US20100264234A1 (en) * 2009-04-20 2010-10-21 Zobele Holding S.P.A. Liquid atomiser with piezoelectric vibration device having an improved electronic control circuit, and activation method thereof
WO2012024631A1 (en) * 2010-08-20 2012-02-23 Bio-Rad Laboratories, Inc. System and method for ultrasonic transducer control
CN202497989U (en) * 2012-03-12 2012-10-24 杨义根 Ultrasonic atomizer circuit with adjustable voltage
CN202605462U (en) * 2012-01-12 2012-12-19 利佳精密科技股份有限公司 Atomizer structure with removable spray head
CN202916627U (en) * 2012-10-31 2013-05-01 佛山市顺德区瑞德电子实业有限公司 High energy efficiency supersonic wave atomization energy transducer drive circuit
CN203482181U (en) * 2013-10-14 2014-03-12 欧兰普电子科技(厦门)有限公司 Humidifier atomization circuit with constant power
CN104069978A (en) * 2013-03-25 2014-10-01 厦门市骏耀光电科技有限公司 Ultrasonic atomization device and atomization method
CN104548289A (en) * 2014-12-16 2015-04-29 摩易国际股份有限公司 Atomizer abnormity automatic detection device with replaceable atomizing spray head
CN204411440U (en) * 2012-05-03 2015-06-24 斯坦福设备有限公司 Nebulizer
CN205108609U (en) * 2015-10-12 2016-03-30 王天星 Adjustable circuit that atomizes

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2868444Y (en) * 2005-09-03 2007-02-14 熊武军 Low-pressure driving piezoelectric ceramic atomising-piece atomiser
US7673812B2 (en) * 2007-01-24 2010-03-09 Taidoc Technology Corporation Ultrasonic nebulizer apparatus and method for adjusting an operation frequency and checking an operating state thereof
US20100264234A1 (en) * 2009-04-20 2010-10-21 Zobele Holding S.P.A. Liquid atomiser with piezoelectric vibration device having an improved electronic control circuit, and activation method thereof
WO2012024631A1 (en) * 2010-08-20 2012-02-23 Bio-Rad Laboratories, Inc. System and method for ultrasonic transducer control
CN202605462U (en) * 2012-01-12 2012-12-19 利佳精密科技股份有限公司 Atomizer structure with removable spray head
CN202497989U (en) * 2012-03-12 2012-10-24 杨义根 Ultrasonic atomizer circuit with adjustable voltage
CN204411440U (en) * 2012-05-03 2015-06-24 斯坦福设备有限公司 Nebulizer
CN202916627U (en) * 2012-10-31 2013-05-01 佛山市顺德区瑞德电子实业有限公司 High energy efficiency supersonic wave atomization energy transducer drive circuit
CN104069978A (en) * 2013-03-25 2014-10-01 厦门市骏耀光电科技有限公司 Ultrasonic atomization device and atomization method
CN203482181U (en) * 2013-10-14 2014-03-12 欧兰普电子科技(厦门)有限公司 Humidifier atomization circuit with constant power
CN104548289A (en) * 2014-12-16 2015-04-29 摩易国际股份有限公司 Atomizer abnormity automatic detection device with replaceable atomizing spray head
CN205108609U (en) * 2015-10-12 2016-03-30 王天星 Adjustable circuit that atomizes

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108355210A (en) * 2018-02-27 2018-08-03 华健 Variable-frequency and variable-voltage atomizer
WO2019165663A1 (en) * 2018-02-27 2019-09-06 华健 Atomizer having variable frequency and variable voltage
EP3782681A4 (en) * 2018-04-20 2022-01-12 Sunshine Lake Pharma Co., Ltd. Atomization apparatus and quick atomization method
CN108815654A (en) * 2018-04-24 2018-11-16 张莹 A kind of novel Respiratory Medicine atomization oxygenerator
CN109150159A (en) * 2018-10-08 2019-01-04 广州厚达电子科技有限公司 The ultrasonic ultrasonic delay line memory driving circuit and driving method of Low-voltage Low-power
CN109127257A (en) * 2018-10-29 2019-01-04 无锡中微爱芯电子有限公司 A kind of atomizer dedicated control circuit
CN110243433A (en) * 2019-05-21 2019-09-17 广州畅呼医疗器械有限公司 A kind of water shortage detection system, method and the atomizer of atomizer
CN113813478A (en) * 2021-10-11 2021-12-21 河南省儿童医院郑州儿童医院 Automatic control method and system for drug delivery of atomizer
CN113976380A (en) * 2021-10-27 2022-01-28 深圳宇凡微电子有限公司 Method for driving atomization sheet to work by self-made high-frequency pwm signal of single chip microcomputer

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