CN105125776A - Chinese and western medicine compound spray for treating acute mastitis - Google Patents
Chinese and western medicine compound spray for treating acute mastitis Download PDFInfo
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Abstract
The invention discloses a Chinese and western medicine compound spray for treating acute mastitis, belonging to the technical field of medicines. The Chinese and western medicine compound spray comprises the following components in parts by weight: 1.2-2.0 parts of flunixin, 0.3-1.0 part of thiourea, 2-5 parts of glucan, 1.5-5 parts of N,N-dimethylacetamide, 0.1-0.2 part of an acid-binding agent, and 3-7 parts of a Chinese herbal medicine compound component, wherein the Chinese herbal medicine compound component is prepared by extracting the following Chinese herbal medicine raw materials in percentage by weight: 35% of violet, 8% of colocasia konishii, 11% of herb of oriental dodartia, 5% of lilac daphne flower buds, 6% of Wikstroemia indica (L.) C. A. Mey., 22% of birch bark, 3% of herb of wilson yarrow, and 10% of metaplexis japonica. The Chinese and western medicine compound spray is prepared by selecting multiple Chinese herbal medicines, extracting the active ingredients thereof, and matching the active ingredients with the western medicine components with different efficacies, so that the purpose of jointly treating acute mastitis is achieved, the efficacies of diminishing inflammation and dispelling swelling, activating blood circulation to remove meridian obstruction, clearing away heat and toxic materials, resisting bacteria and viruses are achieved, and the Chinese and western medicine compound spray is convenient to use, high in content of active ingredients, rapid in taking effect, and obvious in curative effect.
Description
Technical field
The present invention relates to medical art, specifically relate to a kind of Chinese medicine and western medicine compound spray for the treatment of acute mastitis.
Background technology
Acute mastitis (acutemastitis) is that the acute festering type of mammary gland infects, it is in lactiferous ducts and surrounding connective tissue inflammation, be everlasting and form abscess in a short time, how caused by staphylococcus aureus or streptococcus are invaded along lymphatic vessel, human milk silt is also conducive to the breeding invading antibacterial.Human milk silt and antibacterial intrusion are two key factors of acute mastitis.The multiple women being born in the postpartum breastfeeding phase, especially primipara is more common.Pathogenic bacteria, generally from nipple cut or intrusion of chapping, also directly can invade and cause infection.The easy acute mastitis of primipara cause the obstruction of latex dust relevant with its milk containing more Exfoliative cells and tissue debris.Blocking latex dust can make the vigor of breast tissue reduce, and the catabolite of human milk silt in addition, makes it the growth and breeding being more conducive to antibacterial, becomes the good culture medium of antibacterial.Have that bibliographical information acute mastitis primipara is ill accounts for 50%, primipara is 2.4: 1 with the ratio of multipara.Any time of age of sucking all can occur, but the most common with 3 ~ 4 weeks puerperal, therefore also known as puerperal mastitis.
Clinical manifestation is breast local, side distending pain, and skin is red, swollen, hot or have lump, tenderness, even occurs shiver with cold, height is warm, general fatigue is unable, has fluctuation when being partially formed abscess.At the acute simplex mastitis initial stage, distending pain of the breast, Pi Wengao, tenderness, because of the stasis of milk, the backflow of vein and lymph is not smooth, and ill-defined scleroma appears in breast local.This stage, then inflammation can dissipate if correctly process.Form acute purulent mammitis local skin mid-term red, swollen, hot, bitterly, obviously, tenderness increases the weight of in scleroma.The systemic toxicity profiles symptoms such as patient's shiver with cold, high heat, headache, unable, arteries and veins is fast.Ipsilateral axillary lymphadenectasis, pain.Abscess Formation period, acute mastitis localization, namely forms acute abscess of breast.Now lump fluctuation, shows shallow abscess fluctuation relatively obvious.Abscess can outside ulceration, also inwardly can penetrate latex dust by ulceration, discharge pus from nipple.Break after breast when abscess and then form retromammary abscess to open texture before pectoralis major.
Acute mastitis western medical treatment method comprises Drug therapy and operative treatment, early stage is all treat with medicine, such as: local 25% magnesium sulfate hot-wet compress, physical therapy, or adopt penicillin 800,000 ~ 1,000,000 U to add 1% ~ 2% procaine 10ml to be dissolved in isotonic saline solution 10 ~ 20ml, in lump periphery seal injection, whole body application antibiotic time serious, to prevent and treat severe infections and septicemia, antibiotic is selected, if desired intravenous drip antibiotic according to antibacterial culturing and susceptibility.Western medical treatment effect is fast, but has side effect, is harmful to, is also unfavorable for growing up healthy and sound of baby to anemia of pregnant woman's health.And Chinese traditional treatment effect is slow, therefore need the medicine developing a kind of instant effect, eutherapeutic treatment acute mastitis.
Summary of the invention
The technical problem that the present invention solves is to provide the Chinese medicine and western medicine compound spray of a kind of instant effect, eutherapeutic treatment acute mastitis.
Technical scheme of the present invention is, a kind of Chinese medicine and western medicine compound spray for the treatment of acute mastitis, its material composition, with parts by weight be: flunixin 1.2 ~ 2.0 parts, thiourea 0.3 ~ 1.0 part, glucosan 2 ~ 5 parts, N, N-dimethyl acetylamide 1.5 ~ 5 parts, acid binding agent 0.1 ~ 0.2 part, Chinese herbal medicine composite parts 3 ~ 7 parts, described Chinese herbal medicine composite parts is extracted by following herbal raw material to be prepared from: 35% Herba Violae diffusae, 8% Rhizoma Remusatiae Viviparae, 11% Herba Dodartiae Orientalis, 5% Flos Genkwa, 6% Pu silver, 22% Cortex Betulae Luminiferae, 3% Herba Achillea Wilsonianae, 10% Herba seu radix metaplexis.
Further, described acid binding agent is triethylamine, and in alkalescence, protection medicinal herb components does not interact with western medicine composition.
Further, described a kind of Chinese medicine and western medicine compound spray for the treatment of acute mastitis, its preparation method comprises the following steps:
(1) prepare Chinese herbal medicine composite parts, get each herbal raw material in proportion, and as follows to the processing mode of each raw material:
A. Herba Violae diffusae: be the soak with ethanol 5 ~ 10 hours of 70% ~ 80% with the determining alcohol relative to its 3 ~ 5 times of weight by Herba Violae diffusae, then heating and refluxing extraction 1 ~ 2 hour, with 200 order filter-cloth filterings, obtain the first filtrate; By filtering residue again by the soak with ethanol of the determining alcohol 70% ~ 80% of 1 ~ 2 times relative to the mixture quality obtained, heating and refluxing extraction 1 ~ 2 hour, with 200 order filter-cloth filterings, obtains the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into medicinal liquid water content be 45 ~ 50%;
B. Rhizoma Remusatiae Viviparae: the water of Rhizoma Remusatiae Viviparae relative to its 5 ~ 6 times of weight is heated, coolant-temperature gage is 80 ~ 100 DEG C, then be the alcohol reflux 2 ~ 3 times of 85 ~ 95% with determining alcohol, each extraction time is 0.5 ~ 1h, with 200 order filter-cloth filterings, merge extractive liquid, being concentrated into medicinal liquid water content is 45 ~ 50%, for subsequent use;
C. Herba Dodartiae Orientalis: by Herba Dodartiae Orientalis with relative to its 10 times of weight 75% soak with ethanol 1.5 hours, then in ultrasonic extractor with 40KHz frequency, at room temperature ultrasonic extraction 30min, obtain with 200 order filter-cloth filterings and once extract filtrate; Filtering residue uses 75% ethanol of 8 times of weight at same frequency at room temperature ultrasonic extraction 20min again again, and 200 order filter-cloth filterings obtain second extraction filtrate; Twice filtrate is merged, Distillation recovery ethanol, under reduced pressure 80 DEG C are concentrated to medicinal liquid water content is 45 ~ 50%, for subsequent use;
D. Flos Genkwa: Flos Genkwa is cut into slices, add relative to its 3 ~ 5 times of water gaging reflux, extract, 2 ~ 4 times, each 1 ~ 2 hour, collect Aqueous extracts, medicinal residues 60% ~ 80% alcoholic solution reflux, extract, 1 ~ 3 time, add ethanol 3 ~ 5 times amount at every turn, extract 0.5 ~ 1.5 hour, merge extractive liquid, reclaim ethanol, obtain alcohol extract, mix with above-mentioned Aqueous extracts, carry out 200 order filtrations with inorganic ceramic film, the rate of filtration is 8 ~ 12L/h, collect filtrate, being concentrated into medicinal liquid water content is 45 ~ 50%, obtains genkwanol water extract, stand-by;
E. Pu silver: be the ethanol of 60% with 8 ~ 12 times of determining alcohols by Pu silver, homogenate, centrifugal, obtain centrifugal liquid and centrifugal slag, centrifugal liquid be concentrated into medicinal liquid water content be 45 ~ 50%, stand-by;
F. Cortex Betulae Luminiferae: Cortex Betulae Luminiferae being placed in temperature is that the baking box of 200 ~ 250 DEG C carries out baking 5 ~ 10min, and employing concentration is the saline solution sprinkling process of 1 ~ 3% wherein, the amount of the saline solution sprayed is 1 ~ 4% of Cortex Betulae Luminiferae gross weight, and the baking temperature adjusting Cortex Betulae Luminiferae is again 80 ~ 100 DEG C of baking process, after 10 ~ 15min to be baked, and Cortex Betulae Luminiferae is placed in super micron mill, be ground into 200 orders, being placed in temperature is that the environment of 30 ~ 35 DEG C deposits process 20 ~ 30min, Cortex Betulae Luminiferae powder can be obtained, stand-by;
G. Herba Achillea Wilsonianae: be placed in by Herba Achillea Wilsonianae in extraction pot, adds the water of 6 ~ 10 times amount, 98 ~ 99 DEG C of micro-reflux, extract, 20 ~ 50min that boil, and by extracting solution 200 order filter-cloth filterings, it is 45 ~ 50% that filtrate is concentrated into medicinal liquid water content, stand-by;
H. Herba seu radix metaplexis: Herba seu radix metaplexis is ground into 20 ~ 40 order coarse powder, adds the water of 10 ~ 12 times of weight, extracts 1 ~ 3 hour, with 200 order filter-cloth filterings, filtering residue adds the water of 6 ~ 8 times of weight again, extracts 1 ~ 2 hour, with 200 order filter-cloth filterings, twice filtrate merges, and being concentrated into medicinal liquid water content is 45 ~ 50%, stand-by;
(2) raw material mixing: all herbal raw material extracts obtained in step (1) are added in dispensing canister, mixing speed is adopted to be 60 ~ 70r/min stir process, and carry out hyperthermic treatment according to 0.1 ~ 0.3 DEG C/min, after all raw materials have mixed, adjustment temperature is that 50 ~ 60 DEG C of constant temperature leave standstill process 12 ~ 15min, again described western medicine composition is dissolved in 30% ethanol relative to its gross weight 10 times, be added in dispensing canister, add the ammonia solution of 0.01 ~ 0.03 part 25 ~ 30% again, mixing speed is adopted to be 100 ~ 200r/min stir process, 10 ~ 15min, after mixing, stand-by,
(3) spray is prepared: the medicinal liquid after step (2) finally mixing is added the surfactant of 0.1 ~ 0.3% and the antiseptic of 0.05 ~ 0.06%, utilizes instant sterilizer sterilizing, be then divided in the container with aerosol apparatus.
Further, described surfactant is N-methyl-D-glucosamine, plays hydrotropy effect.
Further, described antiseptic is that eucalyptus oil or acetic acid chloroethene are fixed, the prolong drug shelf-life.
Selected by the present invention, the pharmacologically active of medicine is as follows:
Herba Violae diffusae bitter in the mouth cold in nature, micro-pungent, heat-clearing and toxic substances removing, detumescence and apocenosis, for hepatitis, pertussis, conjunctival congestion and swelling pain; Acute mastitis is controlled in external, furuncle, carbuncle furuncle, herpes zoster, venom, traumatic injury.
Rhizoma Remusatiae Viviparae: taste fiber crops warm in nature, detumescence parasite killing, narcotic analgesic, controls acute mastitis, traumatic injury congestive edema, and carbuncle furuncle swells, tinea scabies.
Herba Dodartiae Orientalis bitter in the mouth is cool in nature, heat-clearing and toxic substances removing; Dispelling wind for relieving itching, main respiratory tract infection, infantile pneumonia, tracheitis, tonsillitis, acute mastitis.
Flos Genkwa acrid in the mouth warm in nature is bitter, poisonous, root bark: subduing swelling and detoxicating, promoting blood circulation and stopping pain, for acute mastitis, doublely controls deep abscess, carbuncle furuncle and phyma poison, tuberculous lymphadenitis, ascites, rheumatalgia, toothache, traumatic injury.
Pu silver bitter in the mouth cold in nature, micro-pungent, poisonous, heat-clearing and toxic substances removing, dissipating phlegm and resolving masses, stimulate the menstrual flow diuretic.Acute mastitis is controlled in external, cellulitis.
The flat bitter in the mouth of Cortex Betulae Luminiferae,
http:// zhongyaocai360.com/zhuzhi/clearing away heat-damp and promoting diuresis, removing toxic substances.For acute tonsillitis, bronchitis, pneumonia, enteritis, dysentery, hepatitis, oliguria yellow skin, acute mastitis.
Herba Achillea Wilsonianae is warm in nature, acrid in the mouth fiber crops, severe toxicity.Promoting blood circulation by removing wind, reducing swelling and alleviating pain.Restore menstrual flow and invigorate blood circulation, anti-inflammation hemostasia.Control traumatic injury, rheumatic arthralgia, stomachache, toothache, amenorrhea is suffered from abdominal pain, and acute mastitis, furuncle swells and ache.
Herba seu radix metaplexis sweet in the mouth warm in nature, strong, promoting flow of QI and blood, subduing swelling and detoxicating.
N,N-dimethylacetamide, is pharmaceutically being used for synthetic antibiotic; Flunixin anti-inflammatory analgesic; Thiourea can be used as antibacterial; Glucosan still has removes free radical, radioprotective, dissolving cholesterol, the infection that prevention hyperlipemia effect and opposing filterable virus, fungus, antibacterial etc. cause.
Operation instruction: suffer from after the breast of acute mastitis cleans up, be sprayed directly on breast, massage 1 ~ 3 minute to absorbing completely, age of sucking should suspend suckling during patient medication, anemia of pregnant woman's forbidding.
The invention has the beneficial effects as follows: Chinese medicine and western medicine compound spray of the present invention is selected Chinese medicine medicines, extract its effective ingredient, and compatibility has the western medicine composition of different efficacies, jointly pull together to treat acute mastitis, reach antiinflammatory and go to swell, promoting blood circulation to restore menstrual flow, heat-clearing and toxic substances removing, the effect of anti-bacteria and anti-virus, easy to use, active constituent content is high, instant effect and evident in efficacy.
Detailed description of the invention
Embodiment 1:
A kind of Chinese medicine and western medicine compound spray for the treatment of acute mastitis, its material composition, with parts by weight be: flunixin 1.2 parts, thiourea 0.3 part, glucosan 2 parts, N, N-dimethyl acetylamide 1.5 parts, acid binding agent 0.1 part, Chinese herbal medicine composite parts 3 parts, described Chinese herbal medicine composite parts is extracted by following herbal raw material to be prepared from: 35% Herba Violae diffusae, 8% Rhizoma Remusatiae Viviparae, 11% Herba Dodartiae Orientalis, 5% Flos Genkwa, 6% Pu silver, 22% Cortex Betulae Luminiferae, 3% Herba Achillea Wilsonianae, 10% Herba seu radix metaplexis.Wherein, described acid binding agent is triethylamine, and in alkalescence, protection medicinal herb components does not interact with western medicine composition.
The Chinese medicine and western medicine compound spray of this treatment acute mastitis, its preparation method comprises the following steps:
(1) prepare Chinese herbal medicine composite parts, get each herbal raw material in proportion, and as follows to the processing mode of each raw material:
A. Herba Violae diffusae: be the soak with ethanol 5 hours of 70% with the determining alcohol relative to its 3 times of weight by Herba Violae diffusae, then heating and refluxing extraction 1 hour, with 200 order filter-cloth filterings, obtain the first filtrate; By filtering residue again by the soak with ethanol of the determining alcohol 70% of 1 times relative to the mixture quality obtained, heating and refluxing extraction 1 hour, with 200 order filter-cloth filterings, obtains the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into medicinal liquid water content be 45%;
B. then Rhizoma Remusatiae Viviparae: heated by the water of Rhizoma Remusatiae Viviparae relative to its 5 times of weight, coolant-temperature gage is 80 DEG C is the alcohol reflux 2 times of 85% with determining alcohol, each extraction time is 0.5h, with 200 order filter-cloth filterings, and merge extractive liquid, being concentrated into medicinal liquid water content is 45%, for subsequent use;
C. Herba Dodartiae Orientalis: by Herba Dodartiae Orientalis with relative to its 10 times of weight 75% soak with ethanol 1.5 hours, then in ultrasonic extractor with 40KHz frequency, at room temperature ultrasonic extraction 30min, obtain with 200 order filter-cloth filterings and once extract filtrate; Filtering residue uses 75% ethanol of 8 times of weight at same frequency at room temperature ultrasonic extraction 20min again again, and 200 order filter-cloth filterings obtain second extraction filtrate; Twice filtrate is merged, Distillation recovery ethanol, under reduced pressure 80 DEG C are concentrated to medicinal liquid water content is 45%, for subsequent use;
D. Flos Genkwa: cut into slices by Flos Genkwa, adds relative to its 3 ~ 5 times of water gaging reflux, extract, 2 times, each 1 hour, collect Aqueous extracts, medicinal residues 60% alcoholic solution reflux, extract, 1 time, add ethanol 3 times amount, extraction 0.5 hour at every turn, merge extractive liquid, reclaims ethanol, obtains alcohol extract, mix with above-mentioned Aqueous extracts, carry out 200 order filtrations with inorganic ceramic film, the rate of filtration is 8L/h, collect filtrate, being concentrated into medicinal liquid water content is 45%, obtains genkwanol water extract, stand-by;
E. Pu silver: be the ethanol of 60% with 8 times of determining alcohols by Pu silver, homogenate, centrifugal, obtain centrifugal liquid and centrifugal slag, centrifugal liquid be concentrated into medicinal liquid water content be 45%, stand-by;
F. Cortex Betulae Luminiferae: Cortex Betulae Luminiferae being placed in temperature is that the baking box of 200 DEG C carries out baking 5min, and employing concentration is the saline solution sprinkling process of 1% wherein, the amount of the saline solution sprayed is 1% of Cortex Betulae Luminiferae gross weight, and the baking temperature adjusting Cortex Betulae Luminiferae is again 80 DEG C of baking process, after 10min to be baked, and Cortex Betulae Luminiferae is placed in super micron mill, be ground into 200 orders, being placed in temperature is that the environment of 30 DEG C deposits process 20min, can obtain Cortex Betulae Luminiferae powder, stand-by;
G. Herba Achillea Wilsonianae: be placed in by Herba Achillea Wilsonianae in extraction pot, adds the water of 6 times amount, 98 DEG C of micro-reflux, extract, 20min that boil, and by extracting solution 200 order filter-cloth filterings, it is 45% that filtrate is concentrated into medicinal liquid water content, stand-by;
H. Herba seu radix metaplexis: Herba seu radix metaplexis is ground into 20 order coarse powder, adds the water of 10 times of weight, extracts 1 hour, and with 200 order filter-cloth filterings, filtering residue adds the water of 6 times of weight again, extracts 1 hour, and with 200 order filter-cloth filterings, twice filtrate merges, and being concentrated into medicinal liquid water content is 45%, stand-by;
(2) raw material mixing: all herbal raw material extracts obtained in step (1) are added in dispensing canister, mixing speed is adopted to be 60r/min stir process, and carry out hyperthermic treatment according to 0.1 DEG C/min, after all raw materials have mixed, adjustment temperature is that 50 DEG C of constant temperature leave standstill process 12min, again described western medicine composition is dissolved in 30% ethanol relative to its gross weight 10 times, be added in dispensing canister, add the ammonia solution of 0.01 part 25% again, mixing speed is adopted to be 100r/min stir process 10min, after mixing, stand-by;
(3) spray is prepared: the medicinal liquid after step (2) finally mixing is added the surfactant N-methyl-D-glucosamine of 0.1% and the antiseptic eucalyptus oil of 0.05%, utilize instant sterilizer sterilizing, be then divided in the container with aerosol apparatus.
Embodiment 2:
A kind of Chinese medicine and western medicine compound spray for the treatment of acute mastitis, its material composition, with parts by weight be: flunixin 1.6 parts, thiourea 0.65 part, glucosan 3.5 parts, N, N-dimethyl acetylamide 3.25 parts, acid binding agent 0.15 part, Chinese herbal medicine composite parts 5 parts, described Chinese herbal medicine composite parts is extracted by following herbal raw material to be prepared from: 35% Herba Violae diffusae, 8% Rhizoma Remusatiae Viviparae, 11% Herba Dodartiae Orientalis, 5% Flos Genkwa, 6% Pu silver, 22% Cortex Betulae Luminiferae, 3% Herba Achillea Wilsonianae, 10% Herba seu radix metaplexis.Wherein, described acid binding agent is triethylamine, and in alkalescence, protection medicinal herb components does not interact with western medicine composition.
The Chinese medicine and western medicine compound spray of this treatment acute mastitis, its preparation method comprises the following steps:
(1) prepare Chinese herbal medicine composite parts, get each herbal raw material in proportion, and as follows to the processing mode of each raw material:
A. Herba Violae diffusae: be the soak with ethanol 7.5 hours of 75% with the determining alcohol relative to its 45 times of weight by Herba Violae diffusae, then heating and refluxing extraction 1.5 hours, with 200 order filter-cloth filterings, obtain the first filtrate; By filtering residue again by the soak with ethanol of the determining alcohol 75% of 1.5 times relative to the mixture quality obtained, heating and refluxing extraction 1.5 hours, with 200 order filter-cloth filterings, obtains the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into medicinal liquid water content be 47.5%;
B. then Rhizoma Remusatiae Viviparae: heated by the water of Rhizoma Remusatiae Viviparae relative to its 5.5 times of weight, coolant-temperature gage is 90 DEG C is the alcohol reflux 2 times of 90% with determining alcohol, each extraction time is 0.75h, with 200 order filter-cloth filterings, and merge extractive liquid, being concentrated into medicinal liquid water content is 47.5%, for subsequent use;
C. Herba Dodartiae Orientalis: by Herba Dodartiae Orientalis with relative to its 10 times of weight 75% soak with ethanol 1.5 hours, then in ultrasonic extractor with 40KHz frequency, at room temperature ultrasonic extraction 30min, obtain with 200 order filter-cloth filterings and once extract filtrate; Filtering residue uses 75% ethanol of 8 times of weight at same frequency at room temperature ultrasonic extraction 20min again again, and 200 order filter-cloth filterings obtain second extraction filtrate; Twice filtrate is merged, Distillation recovery ethanol, under reduced pressure 80 DEG C are concentrated to medicinal liquid water content is 47.5%, for subsequent use;
D. Flos Genkwa: cut into slices by Flos Genkwa, adds relative to its 4 times of water gaging reflux, extract, 3 times, each 1.5 hours, collect Aqueous extracts, medicinal residues 70% alcoholic solution reflux, extract, 2 times, add ethanol 4 times amount, extraction 1 hour at every turn, merge extractive liquid, reclaims ethanol, obtains alcohol extract, mix with above-mentioned Aqueous extracts, carry out 200 order filtrations with inorganic ceramic film, the rate of filtration is 10L/h, collect filtrate, being concentrated into medicinal liquid water content is 47.5%, obtains genkwanol water extract, stand-by;
E. Pu silver: be the ethanol of 60% with 10 times of determining alcohols by Pu silver, homogenate, centrifugal, obtain centrifugal liquid and centrifugal slag, centrifugal liquid be concentrated into medicinal liquid water content be 47.5%, stand-by;
F. Cortex Betulae Luminiferae: Cortex Betulae Luminiferae being placed in temperature is that the baking box of 225 DEG C carries out baking 7.5min, and employing concentration is the saline solution sprinkling process of 2% wherein, the amount of the saline solution sprayed is 1 ~ 4% of Cortex Betulae Luminiferae gross weight, and the baking temperature adjusting Cortex Betulae Luminiferae is again 90 DEG C of baking process, after 12.5min to be baked, and Cortex Betulae Luminiferae is placed in super micron mill, be ground into 200 orders, being placed in temperature is that the environment of 32.5 DEG C deposits process 25min, can obtain Cortex Betulae Luminiferae powder, stand-by;
G. Herba Achillea Wilsonianae: be placed in by Herba Achillea Wilsonianae in extraction pot, adds the water of 8 times amount, 98.5 DEG C of micro-reflux, extract, 35min that boil, and by extracting solution 200 order filter-cloth filterings, it is 47.5% that filtrate is concentrated into medicinal liquid water content, stand-by:
H. Herba seu radix metaplexis: Herba seu radix metaplexis is ground into 30 order coarse powder, adds the water of 11 times of weight, extracts 2 hours, with 200 order filter-cloth filterings, filtering residue adds the water of 7 times of weight again, extracts 1.5 hours, with 200 order filter-cloth filterings, twice filtrate merges, and being concentrated into medicinal liquid water content is 47.5%, stand-by;
(2) raw material mixing: all herbal raw material extracts obtained in step (1) are added in dispensing canister, mixing speed is adopted to be 65r/min stir process, and carry out hyperthermic treatment according to 0.2 DEG C/min, after all raw materials have mixed, adjustment temperature is that 55 DEG C of constant temperature leave standstill process 13.5min, again described western medicine composition is dissolved in 30% ethanol relative to its gross weight 10 times, be added in dispensing canister, add the ammonia solution of 0.02 part 27.5% again, mixing speed is adopted to be 150r/min stir process 12.5min, after mixing, stand-by:
(3) spray is prepared: the medicinal liquid after step (2) finally mixing is added the surfactant N-methyl-D-glucosamine of 0.2% and the antiseptic eucalyptus oil of 0.055%, utilize instant sterilizer sterilizing, be then divided in the container with aerosol apparatus.
Embodiment 3:
A kind of Chinese medicine and western medicine compound spray for the treatment of acute mastitis, its material composition, with parts by weight be: flunixin 2.0 parts, thiourea 1.0 parts, glucosan 5 parts, N, N-dimethyl acetylamide 5 parts, acid binding agent 0.2 part, Chinese herbal medicine composite parts 7 parts, described Chinese herbal medicine composite parts is extracted by following herbal raw material to be prepared from: 35% Herba Violae diffusae, 8% Rhizoma Remusatiae Viviparae, 11% Herba Dodartiae Orientalis, 5% Flos Genkwa, 6% Pu silver, 22% Cortex Betulae Luminiferae, 3% Herba Achillea Wilsonianae, 10% Herba seu radix metaplexis.Wherein, described acid binding agent is triethylamine, and in alkalescence, protection medicinal herb components does not interact with western medicine composition.
The Chinese medicine and western medicine compound spray of this treatment acute mastitis, its preparation method comprises the following steps:
(1) prepare Chinese herbal medicine composite parts, get each herbal raw material in proportion, and as follows to the processing mode of each raw material:
A. Herba Violae diffusae: be the soak with ethanol 10 hours of 80% with the determining alcohol relative to its 5 times of weight by Herba Violae diffusae, then heating and refluxing extraction 2 hours, with 200 order filter-cloth filterings, obtain the first filtrate; By filtering residue again by the soak with ethanol of the determining alcohol 780% of 2 times relative to the mixture quality obtained, heating and refluxing extraction 2 hours, with 200 order filter-cloth filterings, obtains the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into medicinal liquid water content be 45 ~ 50%;
B. then Rhizoma Remusatiae Viviparae: heated by the water of Rhizoma Remusatiae Viviparae relative to its 6 times of weight, coolant-temperature gage is 100 DEG C is the alcohol reflux 3 times of 95% with determining alcohol, each extraction time is 1h, with 200 order filter-cloth filterings, and merge extractive liquid, being concentrated into medicinal liquid water content is 50%, for subsequent use;
C. Herba Dodartiae Orientalis: by Herba Dodartiae Orientalis with relative to its 10 times of weight 75% soak with ethanol 1.5 hours, then in ultrasonic extractor with 40KHz frequency, at room temperature ultrasonic extraction 30min, obtain with 200 order filter-cloth filterings and once extract filtrate; Filtering residue uses 75% ethanol of 8 times of weight at same frequency at room temperature ultrasonic extraction 20min again again, and 200 order filter-cloth filterings obtain second extraction filtrate; Twice filtrate is merged, Distillation recovery ethanol, under reduced pressure 80 DEG C are concentrated to medicinal liquid water content is 50%, for subsequent use;
D. Flos Genkwa: cut into slices by Flos Genkwa, adds relative to its 5 times of water gaging reflux, extract, 4 times, each 2 hours, collect Aqueous extracts, medicinal residues 80% alcoholic solution reflux, extract, 3 times, add ethanol 5 times amount, extraction 1.5 hours at every turn, merge extractive liquid, reclaims ethanol, obtains alcohol extract, mix with above-mentioned Aqueous extracts, carry out 200 order filtrations with inorganic ceramic film, the rate of filtration is 12L/h, collect filtrate, being concentrated into medicinal liquid water content is 50%, obtains genkwanol water extract, stand-by;
E. Pu silver: be the ethanol of 60% with 12 times of determining alcohols by Pu silver, homogenate, centrifugal, obtain centrifugal liquid and centrifugal slag, centrifugal liquid be concentrated into medicinal liquid water content be 50%, stand-by;
F. Cortex Betulae Luminiferae: Cortex Betulae Luminiferae being placed in temperature is that the baking box of 250 DEG C carries out baking 10min, and employing concentration is the saline solution sprinkling process of 3% wherein, the amount of the saline solution sprayed is 4% of Cortex Betulae Luminiferae gross weight, and the baking temperature adjusting Cortex Betulae Luminiferae is again 100 DEG C of baking process, after 15min to be baked, and Cortex Betulae Luminiferae is placed in super micron mill, be ground into 200 orders, being placed in temperature is that the environment of 35 DEG C deposits process 30min, can obtain Cortex Betulae Luminiferae powder, stand-by;
G. Herba Achillea Wilsonianae: be placed in by Herba Achillea Wilsonianae in extraction pot, adds the water of 10 times amount, 99 DEG C of micro-reflux, extract, 50min that boil, and by extracting solution 200 order filter-cloth filterings, it is 50% that filtrate is concentrated into medicinal liquid water content, stand-by;
H. Herba seu radix metaplexis: Herba seu radix metaplexis is ground into 40 order coarse powder, adds the water of 12 times of weight, extracts 3 hours, and with 200 order filter-cloth filterings, filtering residue adds the water of 8 times of weight again, extracts 2 hours, and with 200 order filter-cloth filterings, twice filtrate merges, and being concentrated into medicinal liquid water content is 50%, stand-by;
(2) raw material mixing: all herbal raw material extracts obtained in step (1) are added in dispensing canister, mixing speed is adopted to be 70r/min stir process, and carry out hyperthermic treatment according to 0.3 DEG C/min, after all raw materials have mixed, adjustment temperature is that 60 DEG C of constant temperature leave standstill process 15min, again described western medicine composition is dissolved in 30% ethanol relative to its gross weight 10 times, be added in dispensing canister, add the ammonia solution of 0.03 part 25 ~ 30% again, mixing speed is adopted to be 200r/min stir process 15min, after mixing, stand-by;
(3) spray is prepared: the medicinal liquid after step (2) finally being mixed adds the surfactant N-methyl-D-glucosamine of 0.3% and the antiseptic acetic acid chloroethene of 0.06% is determined, utilize instant sterilizer sterilizing, be then divided in the container with aerosol apparatus.
Clinical test of pesticide effectiveness material and model case:
Patient one: Wei, female, 28 years old.In 23 days first puerperal, left cracked nipple, milk is not smooth, and conscious left distending pain of the breast does not relax, and has 3 cm x, 4 centimetres of hard lumps, red, swollen, burning pain outside left breast, and tenderness is obvious, and with thirsty indigestion and loss of appetite, dry stool yellow urine, Western medicine diagnose is acute mastitis.The present invention is used to treat the Chinese medicine and western medicine compound spray of acute mastitis after 2 days, inflammatory resolution, mass reduction.Continue to take the present invention again and treat the Chinese medicine and western medicine compound spray of acute mastitis after 1 week, lump disappears, and milk is unobstructed, and other symptoms also all disappear.
Patient two: Korea Spro so-and-so, female, 24 years old.18 days puerperal, left breast swelling pain, fear of cold heating 1 week.Left breast redness is scorching hot, and interior upper limb can touch 2 cm x 3 centimetres scleroma block, and tenderness increases the weight of, and milk is not smooth, pale complexion, shiver with cold, and high heat, has a headache unable.Examine as acute mastitis.The present invention is used to treat the Chinese medicine and western medicine compound spray of acute mastitis after 3 days, swell and ache and subtract greatly, cold febrile lysis, continue to take treatment acute mastitis medicine of the present invention 1 week, the present invention is used to treat the Chinese medicine and western medicine compound spray of acute mastitis after one week, all symptoms all disappear, and are rehabilitation after diagnosing.
Patient three: wait certain, female, 25 years old.The 6th day puerperal left breast swelling pain, red swelling of the skin, high heat, general fatigue are unable, are acute mastitis through hospital diagnosis.Intramuscular injection penicillin with 50% Adlerika soak, treat 2 days invalid.Left breast has the lump of 22 cm x 3 centimetres, the enlargement of left axillary lymph knot, breast swell and pain.Use the present invention to treat the Chinese medicine and western medicine compound spray of acute mastitis after 1 day, temperature decline, all diseases alleviate, and continue to take treatment acute mastitis medicine of the present invention 3, and breast swell and pain disappears, and are rehabilitation after diagnosing.
Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in previous embodiment, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of embodiment of the present invention technical scheme.
Claims (5)
1. treat the Chinese medicine and western medicine compound spray of acute mastitis for one kind, it is characterized in that, its material composition, with parts by weight be: flunixin 1.2 ~ 2.0 parts, thiourea 0.3 ~ 1.0 part, glucosan 2 ~ 5 parts, N, N-dimethyl acetylamide 1.5 ~ 5 parts, acid binding agent 0.1 ~ 0.2 part, Chinese herbal medicine composite parts 3 ~ 7 parts, described Chinese herbal medicine composite parts is extracted by following herbal raw material to be prepared from: 35% Herba Violae diffusae, 8% Rhizoma Remusatiae Viviparae, 11% Herba Dodartiae Orientalis, 5% Flos Genkwa, 6% Pu silver, 22% Cortex Betulae Luminiferae, 3% Herba Achillea Wilsonianae, 10% Herba seu radix metaplexis.
2. a kind of Chinese medicine and western medicine compound spray for the treatment of acute mastitis according to claim 1, it is characterized in that, described acid binding agent is triethylamine.
3. a kind of Chinese medicine and western medicine compound spray for the treatment of acute mastitis according to claim 1 and 2, it is characterized in that, its preparation method comprises the following steps:
(1) prepare Chinese herbal medicine composite parts, get each herbal raw material in proportion, and as follows to the processing mode of each raw material:
A. Herba Violae diffusae: be the soak with ethanol 5 ~ 10 hours of 70% ~ 80% with the determining alcohol relative to its 3 ~ 5 times of weight by Herba Violae diffusae, then heating and refluxing extraction 1 ~ 2 hour, with 200 order filter-cloth filterings, obtain the first filtrate; By filtering residue again by the soak with ethanol of the determining alcohol 70% ~ 80% of 1 ~ 2 times relative to the mixture quality obtained, heating and refluxing extraction 1 ~ 2 hour, with 200 order filter-cloth filterings, obtains the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into medicinal liquid water content be 45 ~ 50%;
B. Rhizoma Remusatiae Viviparae: the water of Rhizoma Remusatiae Viviparae relative to its 5 ~ 6 times of weight is heated, coolant-temperature gage is 80 ~ 100 DEG C, then be the alcohol reflux 2 ~ 3 times of 85 ~ 95% with determining alcohol, each extraction time is 0.5 ~ 1h, with 200 order filter-cloth filterings, merge extractive liquid, being concentrated into medicinal liquid water content is 45 ~ 50%, for subsequent use;
C. Herba Dodartiae Orientalis: by Herba Dodartiae Orientalis with relative to its 10 times of weight 75% soak with ethanol 1.5 hours, then in ultrasonic extractor with 40KHz frequency, at room temperature ultrasonic extraction 30min, obtain with 200 order filter-cloth filterings and once extract filtrate; Filtering residue uses 75% ethanol of 8 times of weight at same frequency at room temperature ultrasonic extraction 20min again again, and 200 order filter-cloth filterings obtain second extraction filtrate; Twice filtrate is merged, Distillation recovery ethanol, under reduced pressure 80 DEG C are concentrated to medicinal liquid water content is 45 ~ 50%, for subsequent use;
D. Flos Genkwa: Flos Genkwa is cut into slices, add relative to its 3 ~ 5 times of water gaging reflux, extract, 2 ~ 4 times, each 1 ~ 2 hour, collect Aqueous extracts, medicinal residues 60% ~ 80% alcoholic solution reflux, extract, 1 ~ 3 time, add ethanol 3 ~ 5 times amount at every turn, extract 0.5 ~ 1.5 hour, merge extractive liquid, reclaim ethanol, obtain alcohol extract, mix with above-mentioned Aqueous extracts, carry out 200 order filtrations with inorganic ceramic film, the rate of filtration is 8 ~ 12L/h, collect filtrate, being concentrated into medicinal liquid water content is 45 ~ 50%, obtains genkwanol water extract, stand-by;
E. Pu silver: be the ethanol of 60% with 8 ~ 12 times of determining alcohols by Pu silver, homogenate, centrifugal, obtain centrifugal liquid and centrifugal slag, centrifugal liquid be concentrated into medicinal liquid water content be 45 ~ 50%, stand-by;
F. Cortex Betulae Luminiferae: Cortex Betulae Luminiferae being placed in temperature is that the baking box of 200 ~ 250 DEG C carries out baking 5 ~ 10min, and employing concentration is the saline solution sprinkling process of 1 ~ 3% wherein, the amount of the saline solution sprayed is 1 ~ 4% of Cortex Betulae Luminiferae gross weight, and the baking temperature adjusting Cortex Betulae Luminiferae is again 80 ~ 100 DEG C of baking process, after 10 ~ 15min to be baked, and Cortex Betulae Luminiferae is placed in super micron mill, be ground into 200 orders, being placed in temperature is that the environment of 30 ~ 35 DEG C deposits process 20 ~ 30min, Cortex Betulae Luminiferae powder can be obtained, stand-by;
G. Herba Achillea Wilsonianae: be placed in by Herba Achillea Wilsonianae in extraction pot, adds the water of 6 ~ 10 times amount, 98 ~ 99 DEG C of micro-reflux, extract, 20 ~ 50min that boil, and by extracting solution 200 order filter-cloth filterings, it is 45 ~ 50% that filtrate is concentrated into medicinal liquid water content, stand-by;
H. Herba seu radix metaplexis: Herba seu radix metaplexis is ground into 20 ~ 40 order coarse powder, adds the water of 10 ~ 12 times of weight, extracts 1 ~ 3 hour, with 200 order filter-cloth filterings, filtering residue adds the water of 6 ~ 8 times of weight again, extracts 1 ~ 2 hour, with 200 order filter-cloth filterings, twice filtrate merges, and being concentrated into medicinal liquid water content is 45 ~ 50%, stand-by;
(2) raw material mixing: all herbal raw material extracts obtained in step (1) are added in dispensing canister, mixing speed is adopted to be 60 ~ 70r/min stir process, and carry out hyperthermic treatment according to 0.1 ~ 0.3 DEG C/min, after all raw materials have mixed, adjustment temperature is that 50 ~ 60 DEG C of constant temperature leave standstill process 12 ~ 15min, again described western medicine composition is dissolved in 30% ethanol relative to its gross weight 10 times, be added in dispensing canister, add the ammonia solution of 0.01 ~ 0.03 part 25 ~ 30% again, mixing speed is adopted to be 100 ~ 200r/min stir process, 10 ~ 15min, after mixing, stand-by,
(3) spray is prepared: the medicinal liquid after step (2) finally mixing is added the surfactant of 0.1 ~ 0.3% and the antiseptic of 0.05 ~ 0.06%, utilizes instant sterilizer sterilizing, be then divided in the container with aerosol apparatus.
4. a kind of Chinese medicine and western medicine compound spray for the treatment of acute mastitis according to claim 3, it is characterized in that, described surfactant is N-methyl-D-glucosamine.
5. a kind of Chinese medicine and western medicine compound spray for the treatment of acute mastitis according to claim 3, is characterized in that, described antiseptic is that eucalyptus oil or acetic acid chloroethene are fixed.
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Application publication date: 20151209 |