CN105106980B - Big domestic animal Ultrasonography coupling lubricant and preparation method and application method - Google Patents
Big domestic animal Ultrasonography coupling lubricant and preparation method and application method Download PDFInfo
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Abstract
The present invention relates to a kind of big domestic animal Ultrasonography coupling lubricant and preparation methods and application method.To provide a kind of suitable big domestic animal Ultrasonography couplant, the big domestic animal Ultrasonography of the present invention is made with coupling lubricant of the lauryl sodium sulfate of 10~15 parts by weight and the cocoanut fatty acid diethanolamide of 2~4 parts by weight and other raw materials.The invention further relates to corresponding preparation method and application methods.The big domestic animal Ultrasonography of the present invention is suitble to examination per rectum to use with coupling lubricant, is particularly suitable for the big domestic animal Ultrasonography such as donkey, horse, ox and uses.
Description
Technical field
The present invention relates to a kind of big domestic animal Ultrasonography coupling lubricant and preparation methods and application method.
Background technology
The use of couplant can reduce the air of Ultrasonic-B probe and body surface, and B ultrasound image is made to be more clear not by dry
It disturbs.Ultrasound diagnosis is only carried out in body surface under normal circumstances, and existing couplant can be but certain big with meet demand on the market
The Ultrasonographies such as domestic animal such as horse, donkey, ox require examiner must hold Ultrasonic-B probe enter domestic animal rectum carry out uterus and
The scanning of ovary, this just has the lubricant effect of couplant certain requirement, can be played again without existing coupling on the market
The coupling of examination per rectum lubricating action or lubricant, common couplant cannot meet the lubrication that arm enters rectum by anus
It needs.Also, rectal mucosal skin lesion is easily caused during examination per rectum, common lubricant without bactericidal effect, this
Sample just easily causes the wound infection after domestic animal examination per rectum or the cross-infection of domestic animal recial disease.
The inner walls of rectums of the big domestic animal such as donkey, horse, ox is huge, and fold is more, when carrying out Ultrasonography, Ultrasonic-B probe and rectum
Wall has an air gap, and when rectum B ultrasound is easily interfered by air gap.
Invention content
The technical problem to be solved by the present invention is to how overcome the drawbacks described above of the prior art, a kind of big domestic animal rectum is provided
Ultrasound diagnosis coupling lubricant and preparation method and application method.
In order to solve the above technical problems, the big domestic animal Ultrasonography of the present invention uses coupling lubricant by 0.3~0.6 weight
The card wave of part；The triethanolamine of 0.1~0.5 parts by weight；The lauryl sodium sulfate of 10~15 parts by weight；0.3~0.6 parts by weight
Sodium citrate；The povidone iodine of 3~5 parts by weight；The cocoanut fatty acid diethanolamide of 2~4 parts by weight；4-7 parts by weight
Carboxyethyl cellulose receive and be made with the deionized water of 65~75 parts by weight.So design, as long as gained coupling lubricant is a bit,
Ultrasonic-B probe and the hand of operator can be filled, high lubricating effect is not easy to air-dry, and gained B ultrasound image is more clear.
Composition character and function needed for the present invention are as follows：
(1) lauryl sodium sulfate (SDS) is a kind of white or faint yellow micro- viscous object, belongs to anion surfactant.Easily
It is dissolved in water, it is good with anion, nonionic compatibility, there is good emulsification, foaming, infiltration, decontamination and dispersion performance.
(2) sodium citrate, also known as sodium citrate.Colourless or white crystals particle or crystalline powder, it is odorless, taste is salty, it is cool,
It is soluble easily in water, be insoluble in ethyl alcohol, safe and non-toxic performance.Due to preparing the raw material basic source of sodium citrate in grain, thus absolutely
To safe and reliable, harm not will produce to human health.The United Nations grain farmer does not make its daily intake with the World Health Organization
Any restrictions, it is believed that the product belong to No Poison.Make acidity agent, preservative and antioxidant in the present invention.
(3) povidone iodine, also known as polyketone iodine.It is yellowish-brown to rufous amorphous powder, water-soluble and ethyl alcohol.
Iodine is gradually released in a solvent, plays a kind of slow releasing function, with the sterilizing power being maintained for a long time.Its powerful bactericidal mechanism
Be aoxidize the active group of pathogen magma albumen, and can with the amino of protein in conjunction with and make its denaturation, thus can be effectively
Kill the pathogen such as bacterium, gemma, fungi, virus and protozoon.Strong with sterilizing power, bactericidal range is wide, and irritation is minimum, xanthochromia
Gently, the features such as easy cleaning, no allergic reaction.To staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, gonococcus, Candida albicans
Hundreds of bacterium such as bacterium, virus etc. have quick killing effect.
(4) cocoanut fatty acid diethanolamide (6501) are a kind of faint yellow to amber thick liquids, belong to nonionic
Surfactant, it is particularly evident with anion surfactant compatibility thickening effect when acid.It is soluble easily in water, have good hair
The functions such as bubble, foam stabilizing, infiltration decontamination, hard water resistance.
(5) sodium hydroxyethlcellulose is a kind of stabilizer that making food processing, thickener.With preferable water solubility, match
5 property and stability.
(6) card wave, also referred to as carbomer (carbomer) are handed over pentaerythrite etc. and the acrylic acid that acrylic acid is crosslinked
Join resin, be a kind of very important rheology control agent, the card wave after neutralization is outstanding gel-type vehicle, there is thickening, suspension etc.
Important use, simple for process, stability is good, is widely used in lotion, cream, gel.
(7) triethanolamine, it is colourless to pale yellow transparent thick liquid, it is micro- to have ammonia taste, as the acid for preparing carbomer gel
Alkali nertralizer.
The present invention big domestic animal Ultrasonography preparation method of coupling lubricant, includes the following steps：
(1) the card wave of 0.3~0.6 parts by weight is taken to be added in the deionized water of 30 parts by weight, heating water bath persistently stirs
20min is cooled to room temperature, and obtains A liquid；
(2) it takes three sodium ethoxides of 0.1~0.5 parts by weight to be dissolved in A liquid to be uniformly mixed, obtains B liquid；
(3) sodium citrate of the lauryl sodium sulfate and 0.3~0.6 parts by weight that take 10~15 parts by weight is added 35~45
In the deionized water of parts by weight, 70~80 DEG C are heated to, dissolving postcooling obtains C liquid to room temperature；
(4) it takes the povidone iodine of 3~5 parts by weight to be dissolved in C liquid to be uniformly mixed, obtains D liquid；
(5) it takes the cocoanut fatty acid diethanolamide of 2~4 parts by weight to be incorporated in D liquid, is uniformly mixed and obtains E liquid；
(6) it takes the sodium hydroxyethlcellulose of 4-7 parts by weight to be added in E liquid to be uniformly mixed, obtains F liquid, be then added
B liquid obtained by (2), is uniformly mixed to get product of the present invention.
The application method of the present invention big domestic animal Ultrasonography coupling lubricant, it is characterised in that：Using preceding preparation
Aforementioned big domestic animal Ultrasonography coupling lubricant, and be finished in four hours.
The application method of the present invention big domestic animal Ultrasonography coupling lubricant, it is characterised in that：First respectively in proportion
B liquid and F liquid are prepared, and preserves shady place respectively, by B liquid and F liquid, is uniformly mixed, and be finished in four hours using preceding.
The present invention uses anion surfactant and nonionic surfactant, can fill Ultrasonic-B probe and rectal wall
Gap, exclude air gap interference, can effectively play in Ultrasonography couple, lubricate effect, dosage is few, is not easy to air-dry,
Required raw material purchase is convenient, cheap, is suitble to the examination per rectum of various big domestic animals.
Coordinate the carboxyethyl with efficient sterilizing, the povidone iodine of disinfection and pure natural moistening skin-care effect fine
The plain sodium of dimension, can effectively prevent the possibility of livestock intestinal tract infection and cross-infection in examination per rectum.
The present invention uses anion surfactant and nonionic surfactant, can fill Ultrasonic-B probe and rectal wall
Gap, exclude air gap interference, can effectively play in Ultrasonography couple, lubricate effect, dosage is few, is not easy to air-dry,
Required raw material purchase is convenient, cheap, is suitble to the examination per rectum of various big domestic animals.
Coordinate the carboxyethyl with efficient sterilizing, the povidone iodine of disinfection and pure natural moistening skin-care effect fine
The plain sodium of dimension, can effectively prevent the possibility of livestock intestinal tract infection and cross-infection in examination per rectum.
The big domestic animal Ultrasonography of the present invention is suitble to examination per rectum to use with coupling lubricant, is particularly suitable for donkey, horse, ox
It is used etc. big domestic animal Ultrasonography.
Description of the drawings
Below in conjunction with the accompanying drawings to using common couplant and coupling lubricant of the present invention, examination per rectum institute is carried out to donkey
B ultrasound image is obtained to be compared：
It is that donkey carries out B ultrasound image obtained by examination per rectum that Fig. 1, which is using common couplant,；
Fig. 2 is that 1 gained coupling lubricant of the present embodiment is that donkey carries out B ultrasound image obtained by examination per rectum；
Fig. 3 is that 2 gained coupling lubricant of the present embodiment is that donkey carries out B ultrasound image obtained by examination per rectum；
Fig. 4 is that 3 gained coupling lubricant of the present embodiment is that donkey carries out B ultrasound image obtained by examination per rectum.
Specific implementation mode
Embodiment 1：(1) 3 grams of card wave is taken to be added in 300 grams of deionized water, heating water bath persistently stirs 20min, cold
But to room temperature, A liquid is obtained；
(2) it takes 3 grams of triethanolamine to be dissolved in A liquid to be uniformly mixed, obtains B liquid；
(3) it takes 150 grams of lauryl sodium sulfate and 3 grams of sodium citrate to be added in 400 grams of deionized water, is heated to
75 DEG C, dissolving postcooling obtains C liquid to room temperature；
(4) it takes 50 grams of povidone iodine to be dissolved in C liquid to be uniformly mixed, obtains D liquid；
(5) it takes 40 grams of cocoanut fatty acid diethanolamide to be incorporated in D liquid, is uniformly mixed and obtains E liquid；
(6) it takes 40 grams of sodium hydroxyethlcellulose to be added in E liquid, is uniformly mixed, obtains F liquid, (2) then are added
Gained B liquid is uniformly mixed and couples (I) 989 gram of lubricant to get big domestic animal Ultrasonography of the invention.
Using commercially available common Ultrasonography couplant, gained image is smudgy.As shown in Figure of description 1, together
When, it needs with 30 grams of couplants, the hand of Ultrasonic-B probe and operator could be filled.
It is detected for donkey rectum using the big domestic animal Ultrasonography coupling lubricant (I) of the above-mentioned invention prepared, gained
B ultrasound image clearly, it is clear, as shown in Figure of description 2.
Meanwhile using this big domestic animal Ultrasonography coupling lubricant (I), only needing 15 grams, so that it may by Ultrasonic-B probe and
The hand of operator fills.One side couplant dosage is few in this way, at low cost, and cleans, sterilizes conveniently.
Embodiment 2：(1) 6 grams of card wave is taken to be added in 300 grams of deionized water, heating water bath persistently stirs 20min, cold
But to room temperature, A liquid is obtained；
(2) it takes 1 gram of triethanolamine to be dissolved in A liquid to be uniformly mixed, obtains B liquid；
(3) it takes 125 grams of lauryl sodium sulfate and 6 grams of sodium citrate to be added in 350 grams of deionized water, is heated to
70 DEG C, dissolving postcooling obtains C liquid to room temperature；
(4) it takes 40 grams of povidone iodine to be dissolved in C liquid to be uniformly mixed, obtains D liquid；
(5) it takes 20 grams of cocoanut fatty acid diethanolamide to be incorporated in D liquid, is uniformly mixed and obtains E liquid；
(6) it takes 70 grams of sodium hydroxyethlcellulose to be added in E liquid to be uniformly mixed, obtains F liquid, (2) then are added
Gained B liquid is uniformly mixed and couples (II) 918 gram of lubricant to get big domestic animal Ultrasonography of the invention.
It is detected for donkey rectum using the big domestic animal Ultrasonography coupling lubricant (II) of the above-mentioned invention prepared, institute
It obtains B ultrasound image to be also apparent from, as shown in Figure of description 3.
Embodiment 3：(1) 4 grams of card wave is taken to be added in 300 grams of deionized water, heating water bath persistently stirs 20min, cold
But to room temperature, A liquid is obtained；
(2) it takes 5 grams of triethanolamine to be dissolved in A liquid to be uniformly mixed, obtains B liquid；
(3) it takes 100 grams of lauryl sodium sulfate and 5 grams of sodium citrate to be added in 450 grams of deionized water, is heated to
80 DEG C, dissolving postcooling obtains C liquid to room temperature；
(4) it takes 30 grams of povidone iodine to be dissolved in C liquid to be uniformly mixed, obtains D liquid；
(5) it takes 30 grams of cocoanut fatty acid diethanolamide to be incorporated in D liquid, is uniformly mixed and obtains E liquid；
(6) it takes 55 grams of sodium hydroxyethlcellulose to be added in E liquid to be uniformly mixed, obtains F liquid, (2) then are added
Gained B liquid is uniformly mixed and couples (III) 979 gram of lubricant to get big domestic animal Ultrasonography of the invention.
It is detected for donkey rectum using the big domestic animal Ultrasonography coupling lubricant (III) of the above-mentioned invention prepared, institute
It obtains B ultrasound image to be also apparent from, as shown in Figure of description 3.
Note：Above-described embodiment is all matching while using, and it is small at four to match big domestic animal Ultrasonography coupling lubricant
When interior be finished.More than four hours, gained B ultrasound picture specification book attached drawing 1 are compared, and clarity advantage is declined, slightly.
It prepares B liquid and F liquid in proportion respectively in advance, and preserves shady place respectively, claiming difference in proportion before
B liquid and F liquid are taken, is uniformly mixed, and be finished in four hours, using effect and now with the current identical, summary.
Claims (2)
1. a kind of big domestic animal Ultrasonography coupling lubricant, by the carbomer of 0.3~0.6 parts by weight；0.1~0.5 weight
The triethanolamine of part；The lauryl sodium sulfate of 10~15 parts by weight；The sodium citrate of 0.3~0.6 parts by weight；3~5 parts by weight
Povidone iodine；The cocoanut fatty acid diethanolamide of 2~4 parts by weight；The carboxyethyl cellulose of 4-7 parts by weight receives with 65~
The deionized water of 75 parts by weight is made.
2. a kind of big domestic animal Ultrasonography preparation method of coupling lubricant, includes the following steps：
(1) carbomer of 0.3~0.6 parts by weight is taken to be added in the deionized water of 30 parts by weight, heating water bath persistently stirs
20min is cooled to room temperature, and obtains A liquid；
(2) it takes the triethanolamine of 0.1~0.5 parts by weight to be dissolved in A liquid to be uniformly mixed, obtains B liquid；
(3) 35~45 weight are added in the sodium citrate of the lauryl sodium sulfate and 0.3~0.6 parts by weight that take 10~15 parts by weight
In the deionized water of part, 70~80 DEG C are heated to, dissolving postcooling obtains C liquid to room temperature；
(4) it takes the povidone iodine of 3~5 parts by weight to be dissolved in C liquid to be uniformly mixed, obtains D liquid；
(5) it takes the cocoanut fatty acid diethanolamide of 2~4 parts by weight to be incorporated in D liquid, is uniformly mixed and obtains E liquid；
(6) it takes the sodium hydroxyethlcellulose of 4-7 parts by weight to be added in E liquid, stirs and evenly mixs, obtain F liquid, (2) institute is then added
B liquid is obtained, is stirred and evenly mixed to get product of the present invention.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510643929.0A CN105106980B (en) | 2015-09-30 | 2015-09-30 | Big domestic animal Ultrasonography coupling lubricant and preparation method and application method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510643929.0A CN105106980B (en) | 2015-09-30 | 2015-09-30 | Big domestic animal Ultrasonography coupling lubricant and preparation method and application method |
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| CN105106980B true CN105106980B (en) | 2018-07-31 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4886068A (en) * | 1985-07-29 | 1989-12-12 | Kabushiki Kaisha Toshiba | Ultrasonic coupling agent |
| CN1374133A (en) * | 2002-03-21 | 2002-10-16 | 黎国梓 | B-mode ultrasound coupling agent and its prepn |
| CN101920023A (en) * | 2010-04-24 | 2010-12-22 | 王勇 | Transrectal ultrasound medical coupling agent |
| CN104667304A (en) * | 2015-01-08 | 2015-06-03 | 青岛明药堂医疗股份有限公司 | Ultrasonic coupling agent and preparation method thereof |
-
2015
- 2015-09-30 CN CN201510643929.0A patent/CN105106980B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4886068A (en) * | 1985-07-29 | 1989-12-12 | Kabushiki Kaisha Toshiba | Ultrasonic coupling agent |
| CN1374133A (en) * | 2002-03-21 | 2002-10-16 | 黎国梓 | B-mode ultrasound coupling agent and its prepn |
| CN101920023A (en) * | 2010-04-24 | 2010-12-22 | 王勇 | Transrectal ultrasound medical coupling agent |
| CN104667304A (en) * | 2015-01-08 | 2015-06-03 | 青岛明药堂医疗股份有限公司 | Ultrasonic coupling agent and preparation method thereof |
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| CN105106980A (en) | 2015-12-02 |
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