CN105106320B - Buccal tablet containing Chinese medicine lotus seeds and oyster shell - Google Patents
Buccal tablet containing Chinese medicine lotus seeds and oyster shell Download PDFInfo
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- CN105106320B CN105106320B CN201510557084.3A CN201510557084A CN105106320B CN 105106320 B CN105106320 B CN 105106320B CN 201510557084 A CN201510557084 A CN 201510557084A CN 105106320 B CN105106320 B CN 105106320B
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Abstract
The invention belongs to Chinese medicine or field of health care food, in particular to the buccal tablet containing Chinese medicine lotus seeds and oyster shell.The buccal tablet is composed of the following components in parts by weight: 80-200 parts of lotus seeds Ultramicro-powder, 80-200 parts of oyster shell Ultramicro-powder, 10-20 parts of konjaku powder, 80-200 parts of beta-cyclodextrin, 260-320 parts of filler, 30-90 parts of disintegrating agent, 5-10 parts of glidant and 3-8 parts of lubricant.In the present invention, lotus seeds and oyster shell conjunctive use, concertedness improve patient's excessive internal heat, abscess of throat, canker sore, bleeding gums symptom, also, oyster shell powder can neutralize the bitter taste of lotus nut.When preparing buccal tablet, it is equipped with konjaku powder, makes buccal tablet is not bitter not stick to one's teeth, while being equipped with beta-cyclodextrin to improve the sense organ that oyster shell is rough, numb.Buccal tablet content of the invention is uniform, and property is stablized, and preparation method is easy to operate, is suitable for industrialized production.
Description
Technical field
The invention belongs to Chinese medicine or field of health care food, in particular to the buccal tablet containing Chinese medicine lotus seeds and oyster shell.
Background technique
According to the Compendium of Material Medica introduction of Chinese science and technology encyclopedia and Li Shizhen (1518-1593 A.D.), lotus seeds (containing lotus nut) are that Nymphaeceae belongs to plant
The green plumule of object (Nelumbo nucifera Gaerth) mature seed, is one of important drugs in Chinese medicine.Bitter is cold in nature.
Function hemostasis arresting seminal emission, clearing heart fire, decompression, heart tonifying.It controls thirsty, vexed, spermatorrhea, spit blood, hot eyes pupil pain.Note in " book on Chinese herbal medicine is new again "
What carrying lotus seeds (containing lotus nut) had " clearing away the heart-fire, calming the liver is fiery, rush down spleen fire, drop lung-fire, heat-clearing solution are tired of, promote the production of body fluid to quench thirst, controlling mesh redness "
Effect.But list makes tea lotus seeds (containing lotus nut), and taste is very bitter, it is difficult to entrance, and lotus seeds (containing lotus nut) are used alone
Its effect will receive certain influence.
Oyster alias is called raw oyster, is Ostreidae (ostreae) animal oyster (ostreagigastnunb) and its nearly edge
The entirety of animal is seashell.Oyster be in all foods containing zinc it is the most abundant, every 100g oyster does not include the weight of shell,
Aqueous 87.1%, 71.2mg containing zinc are rich in zinc albuminate, are good zinc supplementation food.Chinese medicine oyster shell powder is during one kind is common
Medicinal material is rich in protein abundant, lipid, and other element needed by human, and taste is salty, puckery, cold nature, return liver, the heart,
Kidney channel, matter important city drop, can dissipate can receive, and have the effect of calming the liver, tranquillizing the mind by relieving convulsion, resolving hard lump, astringency inducing, cure mainly dizziness
Tinnitus, brothers' chatter, palpitation and insomnia are had the fidgets, and frightened epilepsy is demented, scrofula goiter, breast agglomeration, spontaneous sweating, frequent micturition of passing out semen,
Metrorrhagia and metrostaxis leukorrhagia, acid regurgitation stomachache, eczema sore etc..In addition, oyster shell powder has effect, contained carbonic acid to gastric and duodenal ulcer
Calcium has the effects of convergence, relieving haperacidity, analgesic, is conducive to the healing of gastric and duodenal ulcer.Ostreae testa pulverata calcium content is higher, not only right
The dynamic equilibrium for adjusting middle-aged and the old's vivo environment is beneficial, and helps to reduce blood pressure.
In the patent of invention application No. is 201310463921.7, inventor describes makes people not pleasant because lotus nut contains
Bitter taste without being accepted by the public, be experimentally confirmed, ostreae testa pulverata can neutralize the bitter taste of lotus nut, join in ostreae testa pulverata and lotus nut
It closes utilization or ostreae testa pulverata and the lotus seeds conjunctive use containing lotus nut, sensory scores is significantly higher than one pack system lotus nut or one-component
The lotus seeds containing lotus nut use, but still show the sense organ of slight bitter.But basic demand of the buccal tablet in addition to meeting tablet
Except (such as dissolution rate), it is necessary to have tempting color, so that the mouthfeel that user has had.The buccal tablet usually prepared
It will appear not satiny feeling after entrance, this also tends to be the problem of more enabling development person have a headache.To find out its cause, not satiny sense
Feel is since ingredient solution rate each in prescription is inconsistent and the contact surface of tablet and tongue is caused to occur caused by subtle pitted skin.
Therefore, the problem of preparing buccal tablet, not only handling dissolution rate, will also solve the problems, such as mouthfeel.Currently, that there is not been reported is a kind of
Up-to-standard stabilization, the mouth containing flake products in good taste containing Chinese medicine lotus seeds and oyster shell.
Summary of the invention
In view of this, the purpose of the present invention is to provide a kind of buccal tablet containing Chinese medicine lotus seeds and oyster shell and its preparations
The method of the buccal tablet, the buccal tablet content is uniform, and property is stablized, and in the case where lotus seeds and oyster shell are used cooperatively, is equipped with
Konjaku powder makes buccal tablet is not bitter not stick to one's teeth；The preparation method of the buccal tablet, it is easy to operate, it is suitable for industrialized production.
To achieve the above object, the technical solution of the present invention is as follows:
Buccal tablet containing Chinese medicine lotus seeds and oyster shell, in parts by weight, composed of the following components:
The filler is made of lactose and microcrystalline cellulose.
Filler of the invention selects lactose and microcrystalline cellulose to be combined.Preferably, lactose selects spray-dried lactose, flowing
Property is excellent.
Further, the buccal tablet containing Chinese medicine lotus seeds and oyster shell, in parts by weight, composed of the following components:
The filler is made of lactose and microcrystalline cellulose.
Further, the amount ratio of the buccal tablet, the lactose and microcrystalline cellulose is 1-3:1.
Preferably, the amount ratio of lactose and microcrystalline cellulose is 2:1.
Further, the buccal tablet, the partial size of the lotus seeds Ultramicro-powder are 20-100um, the oyster shell Ultramicro-powder
Partial size is 20-100um.In the present invention, it is preferred that control raw material lotus seeds Ultramicro-powder and the partial size of oyster shell Ultramicro-powder are respectively
50-80 μm, above-mentioned filler and other auxiliary material combinations are combined with the present invention, to obtain preferable mobility and compressibility, are made
Convenient for uniformly mixed and compression molding, to obtain up-to-standard stable product.
Further, the buccal tablet, the lotus seeds contain lotus nut.
Further, the weight ratio of the buccal tablet, the lotus seeds Ultramicro-powder and oyster shell Ultramicro-powder is 1-2:1-2.
Preferably, the weight ratio of the lotus seeds Ultramicro-powder and oyster shell Ultramicro-powder is 1.5 ± 0.3:1.3 ± 0.2.
Further, the buccal tablet, the disintegrating agent are sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, crosslinking
One of polyvinylpyrrolidone, croscarmellose sodium are a variety of.
Further, the buccal tablet, the glidant are talcum powder and/or silica.
Further, the buccal tablet, the lubricant be magnesium stearate, superfine silica gel powder, talcum powder, hydrogenated vegetable oil,
One of polyethylene glycol, magnesium laurylsulfate are a variety of.
The present invention also provides a kind of, and the buccal tablet containing Chinese medicine lotus seeds and oyster shell contains following ingredient in detail:
The filler is made of lactose and microcrystalline cellulose.
The present invention also provides the preparation methods of the buccal tablet containing Chinese medicine lotus seeds and oyster shell, including as follows into
Capable step:
1) mixing: filler is micronized, the lotus seeds Ultramicro-powder, oyster shell Ultramicro-powder and the beta-cyclodextrin with proportional quantity
It is sufficiently mixed, obtains mixture；
2) disintegrating agent and glidant is dry after the processing of 80-120 mesh respectively, disintegrating agent must be pre-processed and pretreatment helps
Flow agent；
3) softwood processed: the konjaku powder of proportional quantity is dissolved in the ethanol solution that mass percentage concentration is 5-20%, obtains second
Mixed alkoxide solution；Then by institute in the pretreatment disintegrating agent of mixture, step 2) described in step 1) resulting 2/3 and step 2)
The pretreatment glidant obtained is handled with alcohol mixed solution, obtains softwood；
4) it pelletizes: softwood obtained by step 3) is crossed into 18-24 mesh, dry under the conditions of 55-65 DEG C, being allowed to water content is 3-
5%, obtain particle；
5) tabletting: the pretreatment disintegrating agent of residue 1/3 being added into the particle that step 4) obtains, first mixes 5-10min, then
The mix lubricant 5-10min of proportional quantity is added, carries out tabletting, obtains buccal tablet.
Beneficial effects of the present invention: in the present invention, lotus seeds and oyster shell conjunctive use, concertedness improve patient and get angry, swallow
Larynx swelling and pain, canker sore, bleeding gums symptom.Also, oyster shell powder can neutralize the bitter taste of lotus nut.When preparing buccal tablet,
In the case where lotus seeds and oyster shell are used cooperatively, it is equipped with konjaku powder, makes buccal tablet is not bitter not stick to one's teeth.It is equipped with β-ring paste simultaneously
Essence is to improve the sense organ that oyster shell is puckery, numb.The buccal convenience of buccal tablet of the invention, it is in good taste, with enhancing immunity of organisms, clearly
Thermal detoxification, the effect of promoting the production of body fluid to quench thirst.Pharyngitis, oral inflammation and oral peculiar smell, throat discomfort, excessive internal heat, canker sore, gum are gone out
The symptoms such as blood have positive effect, are dual-purpose of drug and food health foods.Buccal tablet content of the invention is uniform, and property is stablized, preparation
Method is easy to operate, is suitable for industrialized production.
Specific embodiment
Illustrated embodiment is to preferably be illustrated to the contents of the present invention, but is not that the contents of the present invention only limit
In illustrated embodiment.So those skilled in the art carry out nonessential change to embodiment according to foregoing invention content
Into and adjustment, still fall within protection scope of the present invention.
Buccal tablet of the embodiment 1 containing Chinese medicine lotus seeds and oyster shell
The mouth containing slice prescription containing Chinese medicine lotus seeds and oyster shell of the present embodiment:
| Component | It forms (g) |
| Lotus seeds Ultramicro-powder (45 μm of partial size) | 150 |
| Oyster shell Ultramicro-powder (50 μm of partial size) | 130 |
| Konjaku powder | 15 |
| Beta-cyclodextrin | 150 |
| Lactose | 200 |
| Microcrystalline cellulose PH302 | 100 |
| Croscarmellose sodium | 60 |
| Silica | 5 |
| Magnesium stearate | 3.5 |
Preparation step is as follows:
1) mixing: filler is micronized, the lotus seeds Ultramicro-powder, oyster shell Ultramicro-powder and the beta-cyclodextrin with proportional quantity
It is sufficiently mixed, obtains mixture；
2) disintegrating agent and glidant is dry after the processing of 80 meshes respectively, disintegrating agent and pretreatment glidant must be pre-processed；
3) softwood processed: the konjaku powder of proportional quantity is dissolved in the ethanol solution that mass percentage concentration is 10%, obtains ethyl alcohol
Mixed solution；Then by gained in the pretreatment disintegrating agent of mixture, step 2) described in step 1) resulting 2/3 and step 2)
Pretreatment glidant handled with alcohol mixed solution, obtain softwood；
4) it pelletizes: softwood obtained by step 3) is crossed into 18 mesh, dry under the conditions of 55-65 DEG C, being allowed to water content is 3-5%,
Obtain particle；
5) tabletting: the pretreatment disintegrating agent of residue 1/3 being added into the particle that step 4) obtains, first mixes 5-10min, then
The mix lubricant 5-10min of proportional quantity is added, carries out tabletting, obtains buccal tablet.
Embodiment 2
The mouth containing slice prescription containing Chinese medicine lotus seeds and oyster shell of the present embodiment:
| Component | It forms (g) |
| Lotus seeds Ultramicro-powder (65 μm of partial size) | 170 |
| Oyster shell Ultramicro-powder (30 μm of partial size) | 170 |
| Konjaku powder | 20 |
| Beta-cyclodextrin | 200 |
| Lactose | 190 |
| Microcrystalline cellulose KG802 | 100 |
| Croscarmellose sodium | 80 |
| Silica | 6 |
| Magnesium stearate | 4 |
Preparation step is as follows:
1) mixing: filler is micronized, the lotus seeds Ultramicro-powder, oyster shell Ultramicro-powder and the beta-cyclodextrin with proportional quantity
It is sufficiently mixed, obtains mixture；
2) disintegrating agent and glidant is dry after the processing of 100 meshes respectively, disintegrating agent and pretreatment glidant must be pre-processed；
3) softwood processed: the konjaku powder of proportional quantity being dissolved in the ethanol solution that mass percentage concentration is 5%, and it is mixed to obtain ethyl alcohol
Close solution；It then will be obtained in the pretreatment disintegrating agent of mixture, step 2) described in step 1) resulting 2/3 and step 2)
Pretreatment glidant is handled with alcohol mixed solution, obtains softwood；
4) it pelletizes: softwood obtained by step 3) is crossed into 20 mesh, dry under the conditions of 55-65 DEG C, being allowed to water content is 3-5%,
Obtain particle；
5) tabletting: the pretreatment disintegrating agent of residue 1/3 being added into the particle that step 4) obtains, first mixes 5-10min, then
The mix lubricant 5-10min of proportional quantity is added, carries out tabletting, obtains buccal tablet.
Embodiment 3
The mouth containing slice prescription containing Chinese medicine lotus seeds and oyster shell of the present embodiment:
| Component | It forms (g) |
| Lotus seeds Ultramicro-powder (85 μm of partial size) | 120 |
| Oyster shell Ultramicro-powder (50 μm of partial size) | 150 |
| Konjaku powder | 12 |
| Beta-cyclodextrin | 180 |
| Lactose | 140 |
| Microcrystalline cellulose PH302 | 140 |
| Croscarmellose sodium | 70 |
| Silica | 10 |
| Magnesium stearate | 5 |
Preparation step is as follows:
1) mixing: filler is micronized, the lotus seeds Ultramicro-powder, oyster shell Ultramicro-powder and the beta-cyclodextrin with proportional quantity
It is sufficiently mixed, obtains mixture；
2) disintegrating agent and glidant is dry after the processing of 100 meshes respectively, disintegrating agent and pretreatment glidant must be pre-processed；
3) softwood processed: the konjaku powder of proportional quantity is dissolved in the ethanol solution that mass percentage concentration is 15%, obtains ethyl alcohol
Mixed solution；Then by gained in the pretreatment disintegrating agent of mixture, step 2) described in step 1) resulting 2/3 and step 2)
Pretreatment glidant handled with alcohol mixed solution, obtain softwood；
4) it pelletizes: softwood obtained by step 3) is crossed into 18 mesh, dry under the conditions of 55-65 DEG C, being allowed to water content is 3-5%,
Obtain particle；
5) tabletting: the pretreatment disintegrating agent of residue 1/3 being added into the particle that step 4) obtains, first mixes 5-10min, then
The mix lubricant 5-10min of proportional quantity is added, carries out tabletting, obtains buccal tablet.
Embodiment 4
The mouth containing slice prescription containing Chinese medicine lotus seeds and oyster shell of the present embodiment:
| Component | It forms (g) |
| Lotus seeds Ultramicro-powder (65 μm of partial size) | 120 |
| Oyster shell Ultramicro-powder (60 μm of partial size) | 100 |
| Konjaku powder | 15 |
| Beta-cyclodextrin | 100 |
| Lactose | 160 |
| Microcrystalline cellulose PH302 | 50 |
| Microcrystalline cellulose KG802 | 80 |
| Crosslinked polyvinylpyrrolidone | 80 |
| Silica | 5 |
| Superfine silica gel powder | 8 |
Preparation step is as follows:
1) mixing: filler is micronized, the lotus seeds Ultramicro-powder, oyster shell Ultramicro-powder and the beta-cyclodextrin with proportional quantity
It is sufficiently mixed, obtains mixture；
2) disintegrating agent and glidant is dry after the processing of 120 meshes respectively, disintegrating agent and pretreatment glidant must be pre-processed；
3) softwood processed: the konjaku powder of proportional quantity is dissolved in the ethanol solution that mass percentage concentration is 20%, obtains ethyl alcohol
Mixed solution；Then by gained in the pretreatment disintegrating agent of mixture, step 2) described in step 1) resulting 2/3 and step 2)
Pretreatment glidant handled with alcohol mixed solution, obtain softwood；
4) it pelletizes: softwood obtained by step 3) is crossed into 24 mesh, dry under the conditions of 55-65 DEG C, being allowed to water content is 3-5%,
Obtain particle；
5) tabletting: the pretreatment disintegrating agent of residue 1/3 being added into the particle that step 4) obtains, first mixes 5-10min, then
The mix lubricant 5-10min of proportional quantity is added, carries out tabletting, obtains buccal tablet.
Embodiment 5
The mouth containing slice prescription containing Chinese medicine lotus seeds and oyster shell of the present embodiment:
| Component | It forms (g) |
| Lotus seeds Ultramicro-powder (25 μm of partial size) | 120 |
| Oyster shell Ultramicro-powder (80 μm of partial size) | 120 |
| Konjaku powder | 20 |
| Beta-cyclodextrin | 150 |
| Lactose | 180 |
| Microcrystalline cellulose KG802 | 90 |
| Sodium carboxymethyl starch | 60 |
| Talcum powder | 6 |
| Magnesium laurylsulfate | 3 |
Preparation step is as follows:
1) mixing: filler is micronized, the lotus seeds Ultramicro-powder, oyster shell Ultramicro-powder and the beta-cyclodextrin with proportional quantity
It is sufficiently mixed, obtains mixture；
2) disintegrating agent and glidant is dry after the processing of 100 meshes respectively, disintegrating agent and pretreatment glidant must be pre-processed；
3) softwood processed: the konjaku powder of proportional quantity is dissolved in the ethanol solution that mass percentage concentration is 10%, obtains ethyl alcohol
Mixed solution；Then by gained in the pretreatment disintegrating agent of mixture, step 2) described in step 1) resulting 2/3 and step 2)
Pretreatment glidant handled with alcohol mixed solution, obtain softwood；
4) it pelletizes: softwood obtained by step 3) is crossed into 20 mesh, dry under the conditions of 55-65 DEG C, being allowed to water content is 3-5%,
Obtain particle；
5) tabletting: the pretreatment disintegrating agent of residue 1/3 being added into the particle that step 4) obtains, first mixes 5-10min, then
The mix lubricant 5-10min of proportional quantity is added, carries out tabletting, obtains buccal tablet.
Embodiment 6
The mouth containing slice prescription containing Chinese medicine lotus seeds and oyster shell of the present embodiment:
| Component | It forms (g) |
| Lotus seeds Ultramicro-powder (60 μm of partial size) | 120 |
| Oyster shell Ultramicro-powder (65 μm of partial size) | 120 |
| Konjaku powder | 20 |
| Beta-cyclodextrin | 120 |
| Lactose | 180 |
| Microcrystalline cellulose PH302 | 90 |
| Croscarmellose sodium | 60 |
| Silica | 6 |
| Magnesium stearate | 3 |
Preparation step is as follows:
1) mixing: filler is micronized, the lotus seeds Ultramicro-powder, oyster shell Ultramicro-powder and the beta-cyclodextrin with proportional quantity
It is sufficiently mixed, obtains mixture；
2) disintegrating agent and glidant is dry after the processing of 120 meshes respectively, disintegrating agent and pretreatment glidant must be pre-processed；
3) softwood processed: the konjaku powder of proportional quantity is dissolved in the ethanol solution that mass percentage concentration is 20%, obtains ethyl alcohol
Mixed solution；Then by gained in the pretreatment disintegrating agent of mixture, step 2) described in step 1) resulting 2/3 and step 2)
Pretreatment glidant handled with alcohol mixed solution, obtain softwood；
4) it pelletizes: softwood obtained by step 3) is crossed into 24 mesh, dry under the conditions of 55-65 DEG C, being allowed to water content is 3-5%,
Obtain particle；
5) tabletting: the pretreatment disintegrating agent of residue 1/3 being added into the particle that step 4) obtains, first mixes 5-10min, then
The mix lubricant 5-10min of proportional quantity is added, carries out tabletting, obtains buccal tablet.
Embodiment 7
The mouth containing slice prescription containing Chinese medicine lotus seeds and oyster shell of the present embodiment:
| Component | It forms (g) |
| Lotus seeds Ultramicro-powder (60 μm of partial size) | 120 |
| Oyster shell Ultramicro-powder (65 μm of partial size) | 120 |
| Lactose | 180 |
| Microcrystalline cellulose PH302 | 90 |
| Croscarmellose sodium | 60 |
| Silica | 6 |
| Magnesium stearate | 3 |
Preparation step is as follows:
1) mixing: filler is micronized, the lotus seeds Ultramicro-powder, oyster shell Ultramicro-powder and the beta-cyclodextrin with proportional quantity
It is sufficiently mixed, obtains mixture；
2) disintegrating agent and glidant is dry after the processing of 120 meshes respectively, disintegrating agent must be pre-processed and pretreatment helps stream
Agent；
3) softwood processed: will be in the pretreatment disintegrating agent of mixture, step 2) described in step 1) resulting 2/3 and step 2)
The ethanol solution that resulting pretreatment glidant mass percentage concentration is 20% is handled, and obtains softwood；
4) it pelletizes: softwood obtained by step 3) is crossed into 24 mesh, dry under the conditions of 55-65 DEG C, being allowed to water content is 3-5%,
Obtain particle；
5) tabletting: the pretreatment disintegrating agent of residue 1/3 being added into the particle that step 4) obtains, first mixes 5-10min, then
The mix lubricant 5-10min of proportional quantity is added, carries out tabletting, obtains buccal tablet.
Embodiment 8
The mouth containing slice prescription containing Chinese medicine lotus seeds and oyster shell of the present embodiment:
| Component | It forms (g) |
| Lotus seeds Ultramicro-powder (60 μm of partial size) | 120 |
| Oyster shell Ultramicro-powder (65 μm of partial size) | 120 |
| Konjaku powder | 20 |
| Beta-cyclodextrin | 120 |
| Lactose | 180 |
| Croscarmellose sodium | 60 |
| Silica | 6 |
| Magnesium stearate | 3 |
Preparation step is as follows:
1) mixing: filler is micronized, the lotus seeds Ultramicro-powder, oyster shell Ultramicro-powder and the beta-cyclodextrin with proportional quantity
It is sufficiently mixed, obtains mixture；
2) disintegrating agent and glidant is dry after the processing of 120 meshes respectively, disintegrating agent and pretreatment glidant must be pre-processed；
3) softwood processed: the konjaku powder of proportional quantity is dissolved in the ethanol solution that mass percentage concentration is 20%, obtains ethyl alcohol
Mixed solution；Then by gained in the pretreatment disintegrating agent of mixture, step 2) described in step 1) resulting 2/3 and step 2)
Pretreatment glidant handled with alcohol mixed solution, obtain softwood；
4) it pelletizes: softwood obtained by step 3) is crossed into 24 mesh, dry under the conditions of 55-65 DEG C, being allowed to water content is 3-5%,
Obtain particle；
5) tabletting: the pretreatment disintegrating agent of residue 1/3 being added into the particle that step 4) obtains, first mixes 5-10min, then
The mix lubricant 5-10min of proportional quantity is added, carries out tabletting, obtains buccal tablet.
Embodiment 9
The mouth containing slice prescription containing Chinese medicine lotus seeds and oyster shell of the present embodiment:
| Component | It forms (g) |
| Lotus seeds Ultramicro-powder (125 μm of partial size) | 120 |
| Oyster shell Ultramicro-powder (120 μm of partial size) | 120 |
| Konjaku powder | 20 |
| Beta-cyclodextrin | 120 |
| Lactose | 180 |
| Microcrystalline cellulose PH302 | 90 |
| Croscarmellose sodium | 60 |
| Silica | 6 |
| Magnesium stearate | 3 |
Preparation step is as follows:
1) mixing: filler is micronized, the lotus seeds Ultramicro-powder, oyster shell Ultramicro-powder and the beta-cyclodextrin with proportional quantity
It is sufficiently mixed, obtains mixture；
2) disintegrating agent and glidant is dry after the processing of 120 meshes respectively, disintegrating agent must be pre-processed and pretreatment helps stream
Agent；
3) softwood processed: the konjaku powder of proportional quantity is dissolved in the ethanol solution that mass percentage concentration is 20%, obtains ethyl alcohol
Mixed solution；Then by gained in the pretreatment disintegrating agent of mixture, step 2) described in step 1) resulting 2/3 and step 2)
Pretreatment glidant handled with alcohol mixed solution, obtain softwood；
4) it pelletizes: softwood obtained by step 3) is crossed into 24 mesh, dry under the conditions of 55-65 DEG C, being allowed to water content is 3-5%,
Obtain particle；
5) tabletting: the pretreatment disintegrating agent of residue 1/3 being added into the particle that step 4) obtains, first mixes 5-10min, then
The mix lubricant 5-10min of proportional quantity is added, carries out tabletting, obtains buccal tablet.
Embodiment 10
The mouth containing slice prescription containing Chinese medicine lotus seeds and oyster shell of the present embodiment:
| Component | It forms (g) |
| Lotus seeds Ultramicro-powder (15 μm of partial size) | 120 |
| Oyster shell Ultramicro-powder (10 μm of partial size) | 120 |
| Konjaku powder | 20 |
| Beta-cyclodextrin | 120 |
| Lactose | 180 |
| Microcrystalline cellulose PH302 | 90 |
| Croscarmellose sodium | 60 |
| Silica | 6 |
| Magnesium stearate | 3 |
Preparation step is as follows:
1) mixing: filler is micronized, the lotus seeds Ultramicro-powder, oyster shell Ultramicro-powder and the beta-cyclodextrin with proportional quantity
It is sufficiently mixed, obtains mixture；
2) disintegrating agent and glidant is dry after the processing of 120 meshes respectively, disintegrating agent must be pre-processed and pretreatment helps stream
Agent；
3) softwood processed: the konjaku powder of proportional quantity is dissolved in the ethanol solution that mass percentage concentration is 20%, obtains ethyl alcohol
Mixed solution；Then by gained in the pretreatment disintegrating agent of mixture, step 2) described in step 1) resulting 2/3 and step 2)
Pretreatment glidant handled with alcohol mixed solution, obtain softwood；
4) it pelletizes: softwood obtained by step 3) is crossed into 24 mesh, dry under the conditions of 55-65 DEG C, being allowed to water content is 3-5%,
Obtain particle；
5) tabletting: the pretreatment disintegrating agent of residue 1/3 being added into the particle that step 4) obtains, first mixes 5-10min, then
The mix lubricant 5-10min of proportional quantity is added, carries out tabletting, obtains buccal tablet.
Experimental example 1
When carrying out hardness, friability and disintegration containing the buccal tablet of Chinese medicine lotus seeds and oyster shell of Example 6-10 preparation
The comparison of limit, as a result as follows:
| Number | 6 | 7 | 8 | 9 | 10 |
| Hardness (N) | 50 | 46 | 35 | 30 | 28 |
| Friability (%) | 0.05 | 0.06 | 0.26 | 0.37 | 0.89 |
| Disintegration time limited (s) | 29 | 27 | 110 | 90 | 65 |
It sees from the above, compared with embodiment 8-9, the mouth containing Chinese medicine lotus seeds and oyster shell of embodiment 6-7 preparation
Lozenge has higher tablet hardness, smaller friability and shorter disintegration time limited.
The evaluation of 2 mouthfeel of test example
The situation of change of buccal tablet organoleptic indicator containing Chinese medicine lotus seeds and oyster shell prepared by embodiment 6,7 is carried out young
Thin observation, evaluates the mouthfeel index of buccal tablet, respectively scores by ten point system, i.e., random invitation 10 has buccal tablet sense organ
The personage of experience is one group, with 10 points for full marks, 6 points the above are preferable, 5 points the following are poor, are made comprehensive system to appraisal result
Meter analysis.The mouthfeel of each buccal tablet of last overall merit.
After being packaged, see Table 1 for details for the result of subjective appreciation index.
The subjective appreciation of 1 buccal tablet of table
3 effect of test example
Choose 60 causes the patient of swelling and aching of gum, bleeding gums, throat discomfort, canker sore to make because eating spicy food
To use object, using buccal tablet prepared by embodiment 6 as test article, therapeutic effect test, mouth are carried out to above-mentioned 60 patients
The effective percentage of lozenge is 100%.
Finally, it is stated that the above examples are only used to illustrate the technical scheme of the present invention and are not limiting, although referring to compared with
Good embodiment describes the invention in detail, those skilled in the art should understand that, it can be to skill of the invention
Art scheme is modified or replaced equivalently, and without departing from the objective and range of technical solution of the present invention, should all be covered at this
In the scope of the claims of invention.
Claims (9)
1. the buccal tablet containing Chinese medicine lotus seeds and oyster shell, which is characterized in that composed of the following components in parts by weight:
80-200 parts of lotus seeds Ultramicro-powder；
80-200 parts of oyster shell Ultramicro-powder；
10-20 parts of konjaku powder；
80-200 parts of beta-cyclodextrin；
260-320 parts of filler；
30-90 parts of disintegrating agent；
5-10 parts of glidant
3-8 parts of lubricant；
The filler is made of lactose and microcrystalline cellulose；The partial size of the lotus seeds Ultramicro-powder is 20-100 μm, the oyster
The partial size of shell Ultramicro-powder is 20-100 μm.
2. buccal tablet according to claim 1, which is characterized in that the amount ratio of the lactose and microcrystalline cellulose is 1-3:
1。
3. buccal tablet according to claim 1, which is characterized in that the lotus seeds contain lotus nut.
4. buccal tablet according to claim 3, which is characterized in that the weight of the lotus seeds Ultramicro-powder and oyster shell Ultramicro-powder
Than for 1-2:1-2.
5. buccal tablet according to claim 1, which is characterized in that the disintegrating agent is sodium carboxymethyl starch, low substitution hydroxyl
One of propyl cellulose, crosslinked polyvinylpyrrolidone, croscarmellose sodium are a variety of.
6. buccal tablet according to claim 1, which is characterized in that the glidant is talcum powder and/or silica.
7. buccal tablet according to claim 1, which is characterized in that the lubricant is magnesium stearate, superfine silica gel powder, talcum
One of powder, hydrogenated vegetable oil, polyethylene glycol, magnesium laurylsulfate are a variety of.
8. the buccal tablet containing Chinese medicine lotus seeds and oyster shell, which is characterized in that composed of the following components in parts by weight:
80-200 parts of lotus seeds Ultramicro-powder；
80-200 parts of oyster shell Ultramicro-powder；
10-20 parts of konjaku powder；
80-200 parts of beta-cyclodextrin；
260-320 parts of filler；
30-90 parts of croscarmellose sodium；
5-10 parts of silica
3-8 parts of magnesium stearate；
The filler is made of lactose and microcrystalline cellulose；The partial size of the lotus seeds Ultramicro-powder is 20-100 μm, the oyster
The partial size of shell Ultramicro-powder is 20-100 μm.
9. the preparation method of the described in any item buccal tablets containing Chinese medicine lotus seeds and oyster shell of claim 1-8, feature exist
In including the steps that carrying out as follows:
1) mixing: filler is micronized, abundant with the lotus seeds Ultramicro-powder, oyster shell Ultramicro-powder and beta-cyclodextrin of proportional quantity
Mixing, obtains mixture；
2) disintegrating agent and glidant is dry after the processing of 80-120 mesh respectively, disintegrating agent must be pre-processed and pretreatment helps stream
Agent；
3) softwood processed: the konjaku powder of proportional quantity being dissolved in the ethanol solution that mass percentage concentration is 5-20%, obtains ethyl alcohol mixing
Solution；It then will be pre- obtained in the pretreatment disintegrating agent of mixture, step 2 described in step 1) resulting 2/3 and step 2
Processing glidant is handled with alcohol mixed solution, obtains softwood；
4) it pelletizes: softwood obtained by step 3) is crossed into 18-24 mesh, dry under the conditions of 55-65 DEG C, being allowed to water content is 3-5%, is obtained
Particle；
5) tabletting: the pretreatment disintegrating agent of residue 1/3 is added into the particle that step 4) obtains, first mixes 5-10min, adds
The mix lubricant 5-10min of proportional quantity carries out tabletting, obtains buccal tablet.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1679879A (en) * | 2004-12-30 | 2005-10-12 | 贵州恒霸药业有限责任公司 | Kouweishu tablets |
| CN1939261A (en) * | 2005-09-26 | 2007-04-04 | 刘凤鸣 | Oral preparation containing cefoperazone schubatain and its making method |
| CN103478842A (en) * | 2013-10-08 | 2014-01-01 | 重庆百农网投资有限公司 | Slightly bitter type beverage and its preparation method |
-
2015
- 2015-09-02 CN CN201510557084.3A patent/CN105106320B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1679879A (en) * | 2004-12-30 | 2005-10-12 | 贵州恒霸药业有限责任公司 | Kouweishu tablets |
| CN1939261A (en) * | 2005-09-26 | 2007-04-04 | 刘凤鸣 | Oral preparation containing cefoperazone schubatain and its making method |
| CN103478842A (en) * | 2013-10-08 | 2014-01-01 | 重庆百农网投资有限公司 | Slightly bitter type beverage and its preparation method |
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