CN1051013C - Water-mixed taken medicine for stopping diarrhea and preparing method - Google Patents
Water-mixed taken medicine for stopping diarrhea and preparing method Download PDFInfo
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- CN1051013C CN1051013C CN96116953A CN96116953A CN1051013C CN 1051013 C CN1051013 C CN 1051013C CN 96116953 A CN96116953 A CN 96116953A CN 96116953 A CN96116953 A CN 96116953A CN 1051013 C CN1051013 C CN 1051013C
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Abstract
The present invention relates to a granule for relieving diarrhea, which is a Chinese patent medicine. The granule for relieving diarrhea is prepared from 10 traditional Chinese medicines of campanumaea pilosula, dried tangerine peel, Chinese yam, licorice root, atractylodes, white hyacinth bean, etc. The preparation method of the granule comprises: processing, crushing, extracting, mixing and granulating the traditional Chinese medicines. Through clinical tests, for diarrhea caused by the insufficiency of both the spleen and the stomach, the granule for relieving diarrhea of the present invention has the total effective rate of 100% for a child group and the total effective rate of 92% for an adult group. The granule for relieving diarrhea has no toxic or side effects, and is a good medicine for relieving diarrhea.
Description
The present invention relates to diarrhea and manufacture method.
Antidiarrheal has many kinds, Western medicine, Chinese medicine is arranged, also have the Chinese medicine and western medicine mixing to manufacture.Norfloxacin is domestic in recent years diarrhea commonly used, but World Health Organization's regulation is forbidden the under-18s minor.Furazolidone also is a diarrhea, but big to stomach irritation.
Order of the present invention is, provides a kind of and all manufactures with Chinese crude drug, and is to adult and child all suitable, is particularly suitable for ZHIXIE CHONGJI of children taking and preparation method thereof.
The inventive method is:
1. concoct: Radix Codonopsis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, Rhizoma Dioscoreae, Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae, Semen Lablab Album, Semen Coicis, Semen Nelumbinis, the Poria of equivalent are selected, clean, dried, wherein the Rhizoma Atractylodis Macrocephalae, Semen Lablab Album, Semen Coicis are fried to yellow standby.
2. pulverize extraction: above-mentioned medical material difference is pulverized secondary separately, cross 100 mesh sieves, other the device preservation of fine powder of collecting the medical material amount 1/2 of respectively distinguishing the flavor of respectively is standby, and all the other coarse powder add decocting.Boil twice; Decocted three hours for the first time, medicinal liquid filters with filter cloth; Device keeping in addition; Decocted two hours for the second time, medicinal liquid filters with filter cloth, and the medicinal liquid that again twice decoction is leached merges heating and is concentrated into thick paste, and equitemperature is at 85 ℃～90 ℃, and recording proportion is 1.3～1.35, and device is preserved standby in addition.
3. the processing of sucrose, starch: sucrose, starch cold drying respectively, pulverize the back and cross 80 mesh sieves, device is preserved standby in addition.
4. mix, granulate: get sucrose, the starch handled well; use the mixer mix homogeneously; equivalent takes by weighing the above-mentioned manufactured fine powder of medical material of respectively distinguishing the flavor of again; use the mixer mix homogeneously; again with Icing Sugar, starch mixed in equal amounts method mix homogeneously; add the thick paste mixing granulation that has prepared, pushed 14 mesh sieves with granulator and make granule.
5. oven dry, granulate: with 80～85 ℃ in steam hot wind circulation baking oven baking about 2 hours, reuse pelletizing machine granulate was crossed 12 mesh sieves, removes coarse granule, removes fine powder after 60 mesh sieves.
6. intermediate inspection: the antidiarrheal that the inventive method is made is the brown particle of dry color and luster unanimity, the sweet little suffering of distinguishing the flavor of, moisture content＜5.0%, granularity: can not and can must not spend 8: 0% with the summation of fine powder by the granule of No. four sieves by a sieve.
The sweet temperature of the Radix Codonopsis of taking in the inventive method is held up the spleen nourishing the stomach, and invigorating the spleen and replenishing QI makes taste healthy and vigorous, and fortuneization power is strong, grows QI and blood; The bitter temperature of the Rhizoma Atractylodis Macrocephalae, the spleen strengthening and damp drying is helped fortuneization; Poria is sweet light, closes with Rhizoma Atractylodis Macrocephalae spleen invigorating eliminating dampness by diuresis; The Semen Coicis removing damp and stopping pain; The Rhizoma Alismatis promoting diuresis to eliminate damp pathogen; The Rhizoma Dioscoreae the kidney invigorating; Semen Nelumbinis are sweet puckery; Semen Lablab Album antidiarrheal; Regulating the flow of vital energy of Pericarpium Citri Reticulatae stagnates; Radix Glycyrrhizae invigorating middle warmer stomach function regulating.
The ZHIXIE CHONGJI that the inventive method is made is done toxicity test through Anhui Province college of traditional Chinese medicine herbal pharmacology chamber, tests with healthy Kunming kind strain mice, and body weight 20 ± 2g, the male and female dual-purpose in 6～7 ages in week, is subjected to the reagent thing: ZHIXIE CHONGJI.During application, be made into 120% Cmax, get 20 of mices during test, male and female half and half, fasting 24 hours with distilled water.Behind 1g ZHIXIE CHONGJI Cmax (120g) and the maximum volume (0.5ml/10g body weight), observed continuously 7 days, the result does not see the mice abnormal state, none death, its maximum tolerated dose MTD is 60g/Kg, and quite the clinical application amount is 83.33 times, and conclusion is that ZHIXIE CHONGJI does not have overt toxicity.
Medicine of the present invention July nineteen ninety-five～JIUYUE has been carried out clinical verification to 100 examples (wherein adult, each 50 example of child) the due to weakness of spleen and stomach patient that has loose bowels, the result is: the child organizes total effective rate 100%, adult treatment group total effective rate is 92%, and matched group is 90%, no significant difference (P＞0.05); ZHIXIE CHONGJI is higher than matched group (P＜0.05) to the total effective rate of diarrhea doing well,improving in the adult group, and onset time is shorter than matched group (P＜0.01), and two groups of the total effective rate of all the other doing well,improvings and onset times are close; No significant difference (P＞0.05), all cases treatment back stool routine examination all obviously improves, and compares significant difference (P＞0.05 or P＜0.01) before the treatment, the patient of clothes ZHIXIE CHONGJI in the adult group, the improvement of rare loose stool in the stool routine examination (stool character) is better than matched group (P＜0.05).
In a word, the ZHIXIE CHONGJI that the inventive method is manufactured is the active drug that the treatment due to weakness of spleen and stomach is had loose bowels, and safety is preferably arranged.
Embodiment:
1. get Radix Codonopsis 100g, Pericarpium Citri Reticulatae 100g, Radix Glycyrrhizae 100g, Rhizoma Dioscoreae 100g, Rhizoma Alismatis 100g, Rhizoma Atractylodis Macrocephalae 100g, Semen Lablab Album 100g, Semen Coicis 100g, Semen Nelumbinis 100g, Poria 100g, sucrose, starch are an amount of, earlier Chinese crude drug are selected, clean, and oven dry, again that the Rhizoma Atractylodis Macrocephalae, Semen Lablab Album, Semen Coicis parch yellow is standby.The above medical material of respectively distinguishing the flavor of is pulverized secondary respectively separately, cross 100 mesh sieves, collect other device of fine powder of the medical material amount 1/2 of respectively distinguishing the flavor of respectively and preserve standby, all the other coarse powder decoct with water twice, amount of water exceeds 10～15 centimeters of powder, decocts three hours for the first time, and medicinal liquid filters with filter cloth, device keeping in addition, decocted two hours for the second time, medicinal liquid filters with filter cloth, and the medicinal liquid that secondary is decocted out and leaches is concentrated into thick paste, equitemperature is in the time of 85 ℃～90 ℃, and recording proportion is that 1.3～1.35 other devices are preserved standby; With sucrose, the starch drying is pulverized the back and is crossed 80 mesh sieves again; use the mixer mix homogeneously, add the medical material fine powder again, Icing Sugar; starch adds the thick paste mixing granulation that has prepared by mixed in equal amounts method mix homogeneously, pushes 14 mesh sieves with granulator and makes granule; and then with 80～85 ℃ in steam hot wind circulation baking oven baking about 2 hours; reuse pelletizing machine granulate is crossed 12 mesh sieves and is removed big grain, makes the 1500g ZHIXIE CHONGJI; use the packer package encapsulation at last, every bag of 12g.
Claims (2)
1. a ZHIXIE CHONGJI is characterized in that it is to be made by Radix Codonopsis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, Rhizoma Dioscoreae, Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae, Semen Lablab Album, Semen Coicis, Semen Nelumbinis, Poria and suitable amount of sucrose and the starch of equivalent.
2. the manufacture method of a ZHIXIE CHONGJI is characterized in that:
A. get Radix Codonopsis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, Rhizoma Dioscoreae, Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae, Semen Lablab Album, Semen Coicis, Semen Nelumbinis, the Poria of equivalent and select, clean, dry, wherein the Rhizoma Atractylodis Macrocephalae, Semen Lablab Album, Semen Coicis are fried to yellow standby;
B. the above medical material of respectively distinguishing the flavor of is pulverized secondary respectively separately, cross 100 mesh sieves, collecting other device of fine powder of the medical material amount 1/2 of respectively distinguishing the flavor of respectively preserves standby, all the other coarse powder decoct with water twice, decocted first three hours, decocted two hours for the second time, the medicinal liquid that decocts out for twice all filters with filter cloth, and proportion is the thick paste of 1.3-1.35 when it is merged heating and be concentrated into temperature and be 85-90 ℃;
C. get suitable amount of sucrose, starch dry respectively, pulverize the back and cross 80 mesh sieves, again with itself and the above-mentioned medical material fine powder mix homogeneously of respectively distinguishing the flavor of, the thick paste that adding has prepared was mixed and made into the granule of 14 mesh sieves.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96116953A CN1051013C (en) | 1996-06-03 | 1996-06-03 | Water-mixed taken medicine for stopping diarrhea and preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96116953A CN1051013C (en) | 1996-06-03 | 1996-06-03 | Water-mixed taken medicine for stopping diarrhea and preparing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1166971A CN1166971A (en) | 1997-12-10 |
| CN1051013C true CN1051013C (en) | 2000-04-05 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96116953A Expired - Lifetime CN1051013C (en) | 1996-06-03 | 1996-06-03 | Water-mixed taken medicine for stopping diarrhea and preparing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1051013C (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100376279C (en) * | 2005-12-29 | 2008-03-26 | 颜怀伟 | Medicine and food dual purpose Chinese medicine for preventing and treating summer heat damp diarrhea and its manufacturing method |
| CN103341148B (en) * | 2013-07-22 | 2015-06-03 | 黄晶晶 | Traditional Chinese medicine preparation for treating infantile diarrhea |
| CN103735996B (en) * | 2014-01-23 | 2016-02-10 | 青岛市第三人民医院 | A kind of Chinese medicine composition for the treatment of infantile diarrhea |
| CN104474204A (en) * | 2014-12-11 | 2015-04-01 | 周连才 | Pharmaceutical composition for treating infantile diarrhea |
| CN104489682B (en) * | 2014-12-29 | 2017-05-17 | 上海交通大学 | White hyacinth bean spleen-tonifying oil tea granules and preparation method thereof |
-
1996
- 1996-06-03 CN CN96116953A patent/CN1051013C/en not_active Expired - Lifetime
Non-Patent Citations (3)
| Title |
|---|
| 《山东医药》1994,34(2) 1994. 2.28 盖秀英等,参苓白术散加味治疗婴幼儿脾虚泄泻40例 * |
| 《河南中医》1984,(2) 1984. 2.28 张志卿,王大夫老中医运用参苓白术散的经验 * |
| 《河南中医》1984,(2) 1984. 2.28 张志卿,王大夫老中医运用参苓白术散的经验;《山东医药》1994,34(2) 1994. 2.28 盖秀英等,参苓白术散加味治疗婴幼儿脾虚泄泻40例 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1166971A (en) | 1997-12-10 |
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Owner name: ANHUI PROVINCE XUEFENG MEDICINE CO., LTD. Free format text: FORMER OWNER: ANHUI PROVINCE XUEFENG PHARMACEUTICAL FACTORY Effective date: 20090626 |
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Effective date of registration: 20090626 Address after: No. 14 Zhonghua Road, Fu Man Town, Anhui, Suzhou Patentee after: Anhui Xuefeng Pharmaceutical Co. Ltd. Address before: No. 14 Zhonghua Road, Fu Man Town, Anhui, Suzhou Patentee before: Anhui Xuefeng Pharmaceutical Factory |
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Owner name: SUZHOU E-FAN PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: ANHUI XUEFENG PHARMACEUTICAL CO., LTD. Effective date: 20150817 |
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Effective date of registration: 20150817 Address after: 234000 north side of Jin Jiang Road, Suzhou Economic Development Zone, Anhui Patentee after: SUZHOU E-FAN PHARMACEUTICAL CO., LTD. Address before: 234101 No. 14 Zhonghua Road, Fu Man Town, Anhui, Suzhou Patentee before: Anhui Xuefeng Pharmaceutical Co. Ltd. |
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