CN1050994C - Enteroclysis medicine Liq.-Acidum pipemidicum syrup for curing diarrhea - Google Patents
Enteroclysis medicine Liq.-Acidum pipemidicum syrup for curing diarrhea Download PDFInfo
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- CN1050994C CN1050994C CN93111213A CN93111213A CN1050994C CN 1050994 C CN1050994 C CN 1050994C CN 93111213 A CN93111213 A CN 93111213A CN 93111213 A CN93111213 A CN 93111213A CN 1050994 C CN1050994 C CN 1050994C
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- China
- Prior art keywords
- pipemidic acid
- present
- coloclysis
- medicinal liquid
- normal saline
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention discloses enema physic liquor for curing diarrhea, which mainly contains pipemidic acid tablets. The present invention can be a mixture of pipemidic acid, physiological saline and alkaline, and can also be a mixture of pipemidic acid and glycerol. The present invention changes administration routes, and exerts higher sterilization action and bacteriostatic action than systemic administration because medicine can directly act on diseased parts. Simultaneously, the present invention avoids toxic effects and side effects of antibiotic by systemic administration. The present invention has obvious curative effects and high cure rate to bacillary dysentery, enteritis, ulcerative colitis, etc. which takes diarrhea as main symptoms.
Description
The present invention is a kind of treatment diarrheal coloclysis medicinal liquid, mainly contains pipemidic acid.
The disease that with diarrhoea is primary symptom is more common in bacillary dysentery, enteritis, ulcerative colitis etc.To these treatment of diseases, all with oral, intramuscular injection or intravenous drip antibiotic, Claritin is main, but the not good enough chronic disease that develops into of curative effect sometimes is not easy radical cure and causes suffering to patient.And above-mentioned Therapeutic Method all has certain difficulty for child patient.Use antibiotic too much simultaneously, be easy to generate poison, pay reaction.As the pipemidic acid tablet is oral medication, and treatment diarrhoea is had certain curative effect, but for than the severe disease feelings, curative effect is relatively poor.
The object of the present invention is to provide a kind of treatment diarrheal coloclysis medicinal liquid, change route of administration, overcome the shortcoming of systemic administration, to treatment diarrhoea curative effect height, cure rate height.
The objective of the invention is to realize in the following way:
Treatment diarrheal coloclysis medicinal liquid comprises the pipemidic acid powder, normal saline and alkali.
Purpose of the present invention can also realize in the following way:
It is 9-10.5 that the addition of alkali makes the PH of medicinal liquid, the one, increased the dissolubility of pipemidic acid, and the 2nd, make medicinal liquid present advantages of higher stability.Alkali can be selected NaOH or NaHCO for use
3Saturated solution adopts the PH reagent paper can measure pH value very easily.
Comprise pipemidic acid 0.5-1.5g in the 50ml normal saline, optimised quantity is 0.5-1.0g.
Preferably add antiseptic in the coloclysis medicinal liquid of the present invention, to increase stability of drug, make its can than long time with storage, antiseptic is the 0.01-0.02 gram in the 50ml normal saline.
A kind of better embodiment of the present invention is the pipemidic acid that adds 0.5-1.5g in the 50ml normal saline, 0.01-0.02g antiseptic, PH is 9-10.5, antiseptic can be selected nipalgin for use, the optimised quantity that pipemidic acid adds is the 0.5-1.0 gram, and the described mix homogeneously of respectively forming gets final product.
Purpose of the present invention can also realize in the following way:
The treatment diarrheal is irritated decoction liquid, comprises pipemidic acid and glycerol, is good to contain pipemidic acid 0.5-1.5g in the 50ml glycerol.
Glycerol has the healing of the ulcer surface of promotion, and antisepsis has special efficacy to the treatment ulcerative colitis behind the adding pipemidic acid.
By the present invention, some other antibiolics also can adopt form of the present invention to treat disease.
Advantage of the present invention:
＜1 〉, the present invention is a kind of enema, directly acts on diseased region-colon after the medicine coloclysis, and the colonic drug level is increased, the efficacy of a drug is concentrated, more can bring into play bigger sterilization, bacteriostasis than systemic administration, avoid systemic administration simultaneously, antibiotic poison, pair effect.
＜2 〉, the present invention makes simply, and is easy to use, basic hospital, clinic, patient can use under family members help.It is uncooperative particularly to have solved the child patient oral medication, fears the problem of pin.
＜3 〉, the coloclysis medicinal liquid that contains pipemidic acid, normal saline, alkaline matter bring down a fever, pain relieving, antidiarrheal, the multiple normal aspects curative effect of stool all is significantly improved than systemic administration.
＜4 〉, the present invention except that having anti-infectious function, can also help to discharge intravital part toxin, the effect that alleviates the whole body poisoning symptom is arranged.
＜5 〉, by matched group relatively, the present invention has tangible raising to being that the bacillary dysentery, enteritis, ulcerative colitis etc. of primary symptom have good curative effect with diarrhoea than systemic administration.
Case one:
Open * *, man, 60 years old, retired worker.It is surplus to suffer from chronic bacillary dysentery 8 years, recurs whenever fatigue, cold drinks and snachs, climate change, all invalid with multiple antibiotic and Chinese medicine.Mainly show as: stomachache, diarrhoea, passage of loose stools band dope, weak, lack of appetite.Through being produce effects 2 times with the present invention's (containing pipemidic acid, normal saline, alkaline matter) coloclysis, transference cure after 6 times, promptly and reuse is consolidated curative effect for 20 times, drug withdrawal is not recurred later six months again.
Case two:
Zhai * *, woman, 57 years old.Year surplus because of stomachache, diarrhoea, the per rectum spectroscopy is diagnosed as ulcerative colitis, the oral administration norfloxacin, and pipemidic acid, the coloclysis metronidazole, prednisone, gentamycin etc. are all invalid.Through with produce effects after the coloclysis of the present invention 6 times, stomachache disappears, diarrhoea again.After again coloclysis consolidate curative effect 20 times, now 5 months, recurrence again.
Embodiment one:
Pipemidic acid powder 0.75g, PH=9, normal saline 50ml
Said medicine is coloclysis medicinal liquid of the present invention after mixing.
Embodiment two:
Pipemidic acid powder 0.5g, PH=9.8, normal saline 50ml, nipalgin 0.015g.
Embodiment three:
The 50ml normal saline, pipemidic acid 1.5g, PH=10.5, nipalgin 0.01g.
Embodiment four:
The 50ml normal saline, pipemidic acid 1.0g, PH=10, nipalgin 0.02g.
Embodiment five:
50ml glycerol, pipemidic acid powder 0.5g
Embodiment six:
50ml glycerol, pipemidic acid powder 1.5g
Claims (11)
1, a kind of treatment diarrheal coloclysis medicinal liquid is characterized in that comprising pipemidic acid powder, normal saline and alkali.
2, coloclysis medicinal liquid according to claim 1 is characterised in that PH is 9-10.5.
3,, be characterised in that to comprise pipemidic acid powder 0.5-1.5g in the 50ml normal saline according to claim 1,2 described coloclysis medicinal liquids.
4, coloclysis medicinal liquid according to claim 3, the amount that is characterised in that described pipemidic acid powder is 0.5-1.0g.
5,, be characterised in that described alkali adopts NaOH or saturated NaHCO according to claim 1,2 described coloclysis medicinal liquids
3Solution.
6, according to claim 1,2 described coloclysis medicinal liquids, be characterised in that also to comprise antiseptic.
7, coloclysis medicinal liquid according to claim 6 is characterised in that to comprise pipemidic acid 0.5-1.5g, antiseptic 0.01-0.02g in the 50ml normal saline.
8, coloclysis medicinal liquid according to claim 6 is characterised in that to comprise pipemidic acid 0.5-1.5g in the 50ml normal saline that nipalgin 0.01-0.02g, PH are 9-10.5.
9, coloclysis medicinal liquid according to claim 8 is characterised in that to comprise pipemidic acid 0.5-1.0g in the 50ml normal saline that 0.01-0.02g nipalgin, PH are 9-10.5.
10, a kind of treatment diarrheal is irritated decoction liquid, is characterised in that to comprise pipemidic acid powder and glycerol.
11, coloclysis medicinal liquid according to claim 10 is characterised in that and contains pipemidic acid 0.5-1.5g in the 50ml glycerol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93111213A CN1050994C (en) | 1993-04-24 | 1993-04-24 | Enteroclysis medicine Liq.-Acidum pipemidicum syrup for curing diarrhea |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93111213A CN1050994C (en) | 1993-04-24 | 1993-04-24 | Enteroclysis medicine Liq.-Acidum pipemidicum syrup for curing diarrhea |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1093903A CN1093903A (en) | 1994-10-26 |
| CN1050994C true CN1050994C (en) | 2000-04-05 |
Family
ID=4989016
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93111213A Expired - Fee Related CN1050994C (en) | 1993-04-24 | 1993-04-24 | Enteroclysis medicine Liq.-Acidum pipemidicum syrup for curing diarrhea |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1050994C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1048730C (en) * | 1998-04-23 | 2000-01-26 | 河南省新乡市第二人民医院 | Zinc pipemidate its synthetic process and zinc pipemidate ointment |
| CN105250305B (en) * | 2015-10-13 | 2019-02-01 | 康普药业股份有限公司 | A kind of pipemidic acid pharmaceutical composition |
| CN111700907A (en) * | 2020-07-24 | 2020-09-25 | 安徽克瑞迪医疗科技有限公司 | Liquid dressing and configuration method |
-
1993
- 1993-04-24 CN CN93111213A patent/CN1050994C/en not_active Expired - Fee Related
Non-Patent Citations (3)
| Title |
|---|
| 《中华传染病杂志》1984,4(4) 1984. 4. 1 吴秀英等,《吡哌酸治疗小儿急性细菌性腹泻疗效观察》 * |
| 《中国农村医学》1988,(10) 1984.10. 1 丁亦明《吡哌酸治疗细菌性肠道感染疗效观察》 * |
| 《中国农村医学》1988,(10) 1984.10. 1 丁亦明《吡哌酸治疗细菌性肠道感染疗效观察》;《中华传染病杂志》1984,4(4) 1984. 4. 1 吴秀英等,《吡哌酸治疗小儿急性细菌性腹泻疗效观察》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1093903A (en) | 1994-10-26 |
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