CN110354136A - A kind of Sodium Aescinate compound buccal lozenge and preparation method thereof for treating canker sore - Google Patents

A kind of Sodium Aescinate compound buccal lozenge and preparation method thereof for treating canker sore Download PDF

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Publication number
CN110354136A
CN110354136A CN201910238241.2A CN201910238241A CN110354136A CN 110354136 A CN110354136 A CN 110354136A CN 201910238241 A CN201910238241 A CN 201910238241A CN 110354136 A CN110354136 A CN 110354136A
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sodium aescinate
sodium
aescinate
buccal lozenge
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徐刚
刘大鹏
刘早霞
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Wuhan Long Lian Laifu Pharmacy Stock Co Ltd
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Wuhan Long Lian Laifu Pharmacy Stock Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention belongs to pharmaceutical technology fields, and in particular to a kind of Sodium Aescinate compound buccal lozenge and preparation method thereof for treating canker sore.This compound buccal lozenge is made of the raw material of following weight parts: 5 ~ 20 parts of Sodium Aescinate, vitamin B210 ~ 40 parts, 2 ~ 15 parts of sweetener, 2 ~ 15 parts of essence, 5 ~ 20 parts of food adhesive, 1 ~ 6 part of borneol, 1 ~ 6 part of mannitol.Preparation method are as follows: supplementary material is ground into after fine powder using powder pressing method direct tablet compressing.The present invention has the effect of anti-inflammatory, detumescence, impervious promotion is colliquating and absorbs out, promotes Stomatocyte regeneration, compared with prior art, can fast and effeciently treat canker sore, for effective component from natural extract, toxic side effect is small.

Description

A kind of Sodium Aescinate compound buccal lozenge and preparation method thereof for treating canker sore
Technical field
The invention belongs to pharmaceutical technology fields, and in particular to a kind of Sodium Aescinate compound buccal lozenge for treating canker sore And preparation method thereof.This compound buccal lozenge is made of the raw material of following weight parts: 5 ~ 20 parts of Sodium Aescinate, vitamin B210~40 Part, 2 ~ 15 parts of sweetener, 2 ~ 15 parts of essence, 5 ~ 20 parts of food adhesive, 1 ~ 6 part of borneol, 1 ~ 6 part of mannitol.Preparation method Are as follows: supplementary material is ground into after fine powder using powder pressing method direct tablet compressing.The present invention have it is anti-inflammatory, detumescence, it is impervious go out, promote The effect of colliquating and absorption, promotion Stomatocyte regeneration, can fast and effeciently treat oral cavity and burst compared with prior art Ulcer, effective component are originated from natural extract, and toxic side effect is small.
Background technique
Sodium Aescinate is the sodium salt of triterpenoid saponin that extracts in the dry mature fruit of Chinese medicine buckeye, at present mostly with total Sodium Aescinate is applied to clinic, mainly contains 4 kinds of ingredients.China's national standard is successively named as before and after liquid chromatogram appearance For Sodium Aescinate A, Sodium Aescinate B, Sodium Aescinate C and Sodium Aescinate D.
The study found that Sodium Aescinate enough reduces vasopermeability, there is apparent suppression to the lysosome activity in serum Production is used, and is stablized lysosome membrane, is hindered the metabolism of protease, and the permeability of capillary, confrontation exudation, to reduce quiet are reduced Arteries and veins is congested, mitigates swollen tissue, reduces the Zhou Jing of swelling, reduce the volume of embolism, reach prevent and treat venous edema, The effect of tissue edema.With anti-inflammatory, it is impervious go out, improve intravenous tension, improve microcirculation, brain function is promoted to restore, promote blood It is swollen to dissolve and absorb, promote the extensive pharmacological action such as adrenocortical secretion corticosteroid and scavenging activated oxygen.It is clinical On be widely used in the diseases such as soft tissue swelling, venous edema caused by treatment a variety of causes, venous leg oedema, vein is bent Etc. venous diseases.Sodium Aescinate is commonly used to injection or oral at present, also has document and patent report for appearance The detumescence of skin, muscle, there is not yet Sodium Aescinate is for oral health health.
Vitamin B2 is the component part (yellow enzyme plays in biological oxidation passs hydrogen effect) of internal yellow enzymes prothetic group, When lacking, the biological oxidation of body is just influenced, makes metabolism that obstacle occur.Its lesion shows as mouth, eye and external genital organs portion more The inflammation of position, such as angular stomatitis, cheilitis, glossitis, eye conjunctivitis and scrotitis, therefore this product can be used for the prevention and treatment of above-mentioned disease.Body The storage of interior vitamin B2 is very limited, therefore will be provided daily by diet.
Canker sore is commonly called as " aphtha ", is a kind of common ulcerative damages illness for betiding mucous membrane of mouth, is more common in The positions such as lip inside, tongue, tongue abdomen, cheek mucous membrane, vestibular ditch, soft palate, the mucous membrane at these positions lack keratinization layer or angling compared with Difference.Tongue ulcer refers to the canker sore for betiding tongue, tongue abdomen position.Sharp ache when canker sore is broken out, local cusalgia are bright Aobvious, serious person also will affect diet, speak, and cause very big inconvenience to daily life；It can concurrent halitosis, chronic pharyngitis, constipation, head Bitterly, the constitutional symptoms such as dizzy, nauseous, out of strength, irritated, fever, enlargement of lymph nodes.Currently, though existing drug therapy has a constant current modulation Effect, but that there are side effects is big, the problems such as being easy recurrent exerbation.Therefore develop it is a kind of have anti-inflammatory, detumescence, it is impervious go out, promote blood The effect of swelling and dissolve and absorb, promoting Stomatocyte regeneration, the drug that can fast and effeciently treat canker sore must have extensively Wealthy market prospects.
Summary of the invention
The present invention provides a kind of Sodium Aescinate compound buccal lozenge and preparation method thereof for treating canker sore, makes it have anti- The effect of scorching, detumescence, impervious promotion is colliquating and absorbs out, promotes Stomatocyte regeneration, can fast and effeciently treat mouth Chamber ulcer.
The present invention is realized using following specific technical solution: a kind of Sodium Aescinate compound that treating canker sore contains Piece and preparation method thereof is made of the raw material of following weight parts: 5 ~ 20 parts of Sodium Aescinate, vitamin B210 ~ 40 parts, sweetener 2 ~ 15 parts, 2 ~ 15 parts of essence, 5 ~ 20 parts of food adhesive, 1 ~ 6 part of borneol, 1 ~ 6 part of mannitol.
Further preferred embodiment is made of the raw material of following weight parts: 10 ~ 15 parts of Sodium Aescinate, vitamin B220~ 30 parts, 5 ~ 10 parts of sweetener, 5 ~ 10 parts of essence, 10 ~ 15 parts of food adhesive, 1 ~ 3 part of borneol, 1 ~ 3 part of mannitol.
Further preferred embodiment is made of the raw material of following weight parts: 12 parts of Sodium Aescinate, 25 parts of vitamin, 8 parts of sweetener, 8 parts of essence, 10 parts of food adhesive, 2 parts of borneol, 2 parts of mannitol.
The Sodium Aescinate is a kind of mixture of sodium salt containing triterpenoid saponin being extracted from plants, mainly Ingredient includes Sodium Aescinate A, Sodium Aescinate B, can also contain or not contain Sodium Aescinate C, Sodium Aescinate D, and Content ratio is unrestricted between Sodium Aescinate A and Sodium Aescinate B both, preferably the content ratio of Sodium Aescinate A For 25-45%, Sodium Aescinate B content ratio is 20-35%.
Two primary medicinal components of the compound buccal lozenge are Sodium Aescinate and vitamin B2。
The sweetener includes one of sucrose, simple syrup and syrupus aromaticus or a variety of；The essence includes thin One of lotus alcohol, peppermint oil, peppermint and its derivative, fruit essence are a variety of；The food adhesive is microcrystalline cellulose Element.
The preparation method of the Sodium Aescinate compound buccal lozenge, comprising the following steps: (1) each supplementary material is taken to grind respectively At fine powder, sieve with 100 mesh sieve spare；(2) each supplementary material fine powder is weighed according to quantity to mix；(3) weigh mix after fine powder about 80 ~ Sodium Aescinate compound buccal lozenge is made in 120mg tabletting.
In the present invention, Sodium Aescinate have it is anti-inflammatory, detumescence, it is impervious go out, promote it is colliquating and absorb etc. functions；Dimension life Plain B2It with prevention and eliminates in oral cavity, the scorching reaction of lip, tongue and skin, promotes the regeneration of cell.Common heat-clearing anti-inflammation drug Mostly oral preparation, period long slow effect；Sodium Aescinate compound buccal lozenge takes the mode that compound buccal lozenge is made in the two, works Fastly, canker sore can fast and effeciently be alleviated to the absorption of drug more conducively at injury.And finished product lozenge is easy to take and store up It deposits.
Specific embodiment
Form is again described in further details the contents of the present invention by the following examples, but not that should not be interpreted as this with regard to this It invents in above-mentioned subject area and is only limitted to following embodiment.It is general according to this field under the premise of not departing from above-mentioned technology of the invention The corresponding modification replaced or change that logical technological know-how and customary means are made, is included in the present invention.
Embodiment 1: a kind of Sodium Aescinate compound buccal lozenge and preparation method thereof for treating canker sore, by following weight parts Raw material composition: 10 parts of Sodium Aescinate, vitamin B210 parts, 15 parts of sweetener, 5 parts of essence, 20 parts of food adhesive, borneol 2 parts, 4 parts of mannitol.The preparation method of the Sodium Aescinate compound buccal lozenge, comprising the following steps: (1) take each original auxiliary respectively Abrasive lapping sieves with 100 mesh sieve spare at fine powder；(2) each supplementary material fine powder is weighed according to quantity to mix；(3) fine powder after mixing is weighed about Sodium Aescinate compound buccal lozenge is made in 120mg tabletting.Clinical test proves, this product have anti-inflammatory, detumescence, it is impervious go out, promote The effect of colliquating and absorption, promotion Stomatocyte regeneration, it can fast and effeciently treat canker sore.
Embodiment 2: a kind of Sodium Aescinate compound buccal lozenge and preparation method thereof for treating canker sore, by following weight parts Raw material composition: 20 parts of Sodium Aescinate, vitamin B240 parts, 2 parts of sweetener, 2 parts of essence, 10 parts of food adhesive, borneol 4 Part, 6 parts of mannitol.The preparation method of the Sodium Aescinate compound buccal lozenge, comprising the following steps: (1) take each original auxiliary respectively Abrasive lapping sieves with 100 mesh sieve spare at fine powder；(2) each supplementary material fine powder is weighed according to quantity to mix；(3) fine powder after mixing is weighed about Sodium Aescinate compound buccal lozenge is made in 100mg tabletting.Clinical test proves, this product have anti-inflammatory, detumescence, it is impervious go out, promote The effect of colliquating and absorption, promotion Stomatocyte regeneration, it can fast and effeciently treat canker sore.
Embodiment 3: a kind of Sodium Aescinate compound buccal lozenge and preparation method thereof for treating canker sore, by following weight parts Raw material composition: 5 parts of Sodium Aescinate, vitamin B230 parts, 10 parts of sweetener, 10 parts of essence, 5 parts of food adhesive, borneol 2 Part, 4 parts of mannitol.The preparation method of the Sodium Aescinate compound buccal lozenge, comprising the following steps: (1) take each original auxiliary respectively Abrasive lapping sieves with 100 mesh sieve spare at fine powder；(2) each supplementary material fine powder is weighed according to quantity to mix；(3) fine powder after mixing is weighed about Sodium Aescinate compound buccal lozenge is made in 80mg tabletting.Clinical test proves, this product have anti-inflammatory, detumescence, it is impervious go out, promote The effect of colliquating and absorption, promotion Stomatocyte regeneration, it can fast and effeciently treat canker sore.
Embodiment 4: a kind of Sodium Aescinate compound buccal lozenge and preparation method thereof for treating canker sore, by following weight parts Raw material composition: 15 parts of Sodium Aescinate, vitamin B220 parts, 5 parts of sweetener, 10 parts of essence, 20 parts of food adhesive, borneol 1 part, 1 part of mannitol.The preparation method of the Sodium Aescinate compound buccal lozenge, comprising the following steps: (1) take each original auxiliary respectively Abrasive lapping sieves with 100 mesh sieve spare at fine powder；(2) each supplementary material fine powder is weighed according to quantity to mix；(3) fine powder after mixing is weighed about Sodium Aescinate compound buccal lozenge is made in 80mg tabletting.Clinical test proves, this product have anti-inflammatory, detumescence, it is impervious go out, promote The effect of colliquating and absorption, promotion Stomatocyte regeneration, it can fast and effeciently treat canker sore.
Embodiment 5: a kind of Sodium Aescinate compound buccal lozenge and preparation method thereof for treating canker sore, by following weight parts Raw material composition: 20 parts of Sodium Aescinate, vitamin B230 parts, 10 parts of sweetener, 5 parts of essence, 5 parts of food adhesive, borneol 2 Part, 2 parts of mannitol.The preparation method of the Sodium Aescinate compound buccal lozenge, comprising the following steps: (1) take each original auxiliary respectively Abrasive lapping sieves with 100 mesh sieve spare at fine powder；(2) each supplementary material fine powder is weighed according to quantity to mix；(3) fine powder after mixing is weighed about Sodium Aescinate compound buccal lozenge is made in 100mg tabletting.Clinical test proves, this product have anti-inflammatory, detumescence, it is impervious go out, promote The effect of colliquating and absorption, promotion Stomatocyte regeneration, it can fast and effeciently treat canker sore.
Embodiment 6: a kind of Sodium Aescinate compound buccal lozenge and preparation method thereof for treating canker sore, by following weight parts Raw material composition: 15 parts of Sodium Aescinate, vitamin B220 parts, 15 parts of sweetener, 5 parts of essence, 10 parts of food adhesive, borneol 4 parts, 6 parts of mannitol.The preparation method of the Sodium Aescinate compound buccal lozenge, comprising the following steps: (1) take each original auxiliary respectively Abrasive lapping sieves with 100 mesh sieve spare at fine powder；(2) each supplementary material fine powder is weighed according to quantity to mix；(3) fine powder after mixing is weighed about Sodium Aescinate compound buccal lozenge is made in 120mg tabletting.Clinical test proves, this product have anti-inflammatory, detumescence, it is impervious go out, promote The effect of colliquating and absorption, promotion Stomatocyte regeneration, it can fast and effeciently treat canker sore.
Embodiment 7: a kind of Sodium Aescinate compound buccal lozenge and preparation method thereof for treating canker sore, by following weight parts Raw material composition: 5 parts of Sodium Aescinate, vitamin B220 parts, 10 parts of sweetener, 10 parts of essence, 10 parts of food adhesive, borneol 6 parts, 2 parts of mannitol.The preparation method of the Sodium Aescinate compound buccal lozenge, comprising the following steps: (1) take each original auxiliary respectively Abrasive lapping sieves with 100 mesh sieve spare at fine powder；(2) each supplementary material fine powder is weighed according to quantity to mix；(3) fine powder after mixing is weighed about Sodium Aescinate compound buccal lozenge is made in 100mg tabletting.Clinical test proves, this product have anti-inflammatory, detumescence, it is impervious go out, promote The effect of colliquating and absorption, promotion Stomatocyte regeneration, it can fast and effeciently treat canker sore.
Embodiment 8: a kind of Sodium Aescinate compound buccal lozenge and preparation method thereof for treating canker sore, by following weight parts Raw material composition: 20 parts of Sodium Aescinate, vitamin B210 parts, 10 parts of sweetener, 5 parts of essence, 5 parts of food adhesive, borneol 6 Part, 40 parts of mannitol.The preparation method of the Sodium Aescinate compound buccal lozenge, comprising the following steps: (1) take each original auxiliary respectively Abrasive lapping sieves with 100 mesh sieve spare at fine powder；(2) each supplementary material fine powder is weighed according to quantity to mix；(3) fine powder after mixing is weighed about Sodium Aescinate compound buccal lozenge is made in 120mg tabletting.Clinical test proves, this product have anti-inflammatory, detumescence, it is impervious go out, promote The effect of colliquating and absorption, promotion Stomatocyte regeneration, it can fast and effeciently treat canker sore.
Embodiment 9: a kind of Sodium Aescinate compound buccal lozenge and preparation method thereof for treating canker sore, by following weight parts Raw material composition: 15 parts of Sodium Aescinate, vitamin B210 parts, 15 parts of sweetener, 2 parts of essence, 20 parts of food adhesive, borneol 4 parts, 1 part of mannitol.The preparation method of the Sodium Aescinate compound buccal lozenge, comprising the following steps: (1) take each original auxiliary respectively Abrasive lapping sieves with 100 mesh sieve spare at fine powder；(2) each supplementary material fine powder is weighed according to quantity to mix；(3) fine powder after mixing is weighed about Sodium Aescinate compound buccal lozenge is made in 120mg tabletting.Clinical test proves, this product have anti-inflammatory, detumescence, it is impervious go out, promote The effect of colliquating and absorption, promotion Stomatocyte regeneration, it can fast and effeciently treat canker sore.
Embodiment 10: a kind of Sodium Aescinate compound buccal lozenge and preparation method thereof for treating canker sore, by following weight The raw material composition of part: 10 parts of Sodium Aescinate, vitamin B230 parts, 15 parts of sweetener, 5 parts of essence, 10 parts of food adhesive, ice 2 parts of piece, 6 parts of mannitol.The preparation method of the Sodium Aescinate compound buccal lozenge, comprising the following steps: (1) take each original respectively Auxiliary material is ground into fine powder, sieves with 100 mesh sieve spare；(2) each supplementary material fine powder is weighed according to quantity to mix；(3) fine powder after mixing is weighed About 80mg tabletting, that is, be made Sodium Aescinate compound buccal lozenge.Clinical test proves, this product have anti-inflammatory, detumescence, it is impervious go out, promote Into it is colliquating and absorb, promote Stomatocyte regeneration the effect of, can fast and effeciently treat canker sore.
Embodiment 11: a kind of Sodium Aescinate compound buccal lozenge and preparation method thereof for treating canker sore, by following weight The raw material composition of part: 12 parts of Sodium Aescinate, vitamin B225 parts, 8 parts of sweetener, 8 parts of essence, 10 parts of food adhesive, ice 2 parts of piece, 2 parts of mannitol.The preparation method of the Sodium Aescinate compound buccal lozenge, comprising the following steps: (1) take each original respectively Auxiliary material is ground into fine powder, sieves with 100 mesh sieve spare；(2) each supplementary material fine powder is weighed according to quantity to mix；(3) fine powder after mixing is weighed About 100mg tabletting, that is, be made Sodium Aescinate compound buccal lozenge.50 canker sore patients are selected, are randomly divided into 2 groups, every group 25 People, one group is taken common anti-inflammatory antipyretic, and one group uses Sodium Aescinate compound buccal lozenge to evaluate canker sore after medication 3 days Improvement, common heat-clearing anti-inflammation drug group effective percentage are 36%, and Sodium Aescinate compound buccal lozenge group effective percentage is 88%.As a result see Following table:
Grouping It cures Improve To no effect Efficient %
Common heat-clearing anti-inflammation drug (25 people) 3 6 16 36
Sodium Aescinate compound buccal lozenge (25 people) 15 7 3 88

Claims (8)

1. a kind of Sodium Aescinate compound buccal lozenge and preparation method thereof for treating canker sore, which is characterized in that by following weight The raw material composition of part: 5 ~ 20 parts of Sodium Aescinate, vitamin B210 ~ 40 parts, 2 ~ 15 parts of sweetener, 2 ~ 15 parts of essence, food it is viscous 5 ~ 20 parts of mixture, 1 ~ 6 part of borneol, 1 ~ 6 part of mannitol.
2. according to Sodium Aescinate compound buccal lozenge according to claim 1, it is characterised in that it is by following portions by weight Raw material composition: 10 ~ 15 parts of Sodium Aescinate, vitamin B220 ~ 30 parts, 5 ~ 10 parts of sweetener, 5 ~ 10 parts of essence, food bonding 10 ~ 15 parts of agent, 1 ~ 3 part of borneol, 1 ~ 3 part of mannitol.
3. according to Sodium Aescinate compound buccal lozenge according to claim 1, it is characterised in that it is by following portions by weight Raw material composition: 12 parts of Sodium Aescinate, 25 parts of vitamin, 8 parts of sweetener, 8 parts of essence, 10 parts of food adhesive, borneol 2 Part, 2 parts of mannitol.
4. the Sodium Aescinate compound buccal lozenge according to claim 1, it is characterised in that the Sodium Aescinate is from Chinese medicine The mixture of the obtained sodium salt containing triterpenoid saponin is extracted in the dry mature fruit of buckeye, main component includes seven leaf soaps Glycosides sodium A, Sodium Aescinate B, Sodium Aescinate C, Sodium Aescinate D are mostly applied to clinic at present with total Sodium Aescinate.
5. according to the Sodium Aescinate compound buccal lozenge described according to claim 1, it is characterised in that primary medicinal component is seven leaves Saponin(e sodium and vitamin B2。
6. according to a kind of Sodium Aescinate compound buccal lozenge for treating canker sore described according to claim 1, it is characterised in that The sweetener includes one of sucrose, simple syrup and syrupus aromaticus or a variety of；The essence includes menthol, peppermint One of oily, peppermint and its derivative, fruit essence are a variety of；The food adhesive is microcrystalline cellulose.
7. a kind of Sodium Aescinate compound buccal lozenge for treating canker sore described in claim 1-6, have anti-inflammatory, detumescence, The effect of impervious promotion is colliquating and absorbs out, promotes Stomatocyte regeneration, can fast and effeciently treat canker sore.
8. according to a kind of Sodium Aescinate compound buccal lozenge for treating canker sore according to claim 1 and its preparation side Method, it is characterised in that the preparation method comprises the following steps: being respectively ground into a powder each supplementary material, sieve with 100 mesh sieve, according to described in claim 3 Parts by weight are mixed, and 80 ~ 120mg of powder after mixing is taken, and it is multiple that Sodium Aescinate is made using direct power compressing method Square lozenge.
CN201910238241.2A 2019-03-27 2019-03-27 A kind of Sodium Aescinate compound buccal lozenge and preparation method thereof for treating canker sore Pending CN110354136A (en)

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Application publication date: 20191022