CN105092497A - Individual blood sugar concentration detecting device and data processing method thereof - Google Patents

Abstract

The invention discloses an individual blood sugar concentration detecting device and a data processing method thereof. The individual blood sugar concentration detecting device comprises an electrochemical blood sugar gathering module and an optical blood sugar gathering module, wherein the electrochemical blood sugar gathering module comprises a reference voltage outputting unit, a current-to-voltage conversion unit, a first numerical-control amplifying unit and a first filtering processing unit; and the optical blood sugar gathering module comprises a microprocessor control unit, a second filtering processing unit, an analog selector unit, an LED (light emitting diode) driving unit, an LED luminous module, a photosensitive sensor, a pre-amplifier unit, a third filtering processing unit and a second numerical-control amplifying unit. The individual blood sugar concentration detecting device has the advantages that fingertip blood drawing frequency is greatly reduced, wounds of a patient are reduced, risks of infection are also reduced, and problems of large errors of optical measurement individuals and low measurement precision are solved.

Description

Individuation blood sugar concentration pick-up unit and data processing method thereof

Technical field

The present invention relates to a kind of in body blood sugar concentration pick-up unit method, specifically, is a kind of individuation blood sugar concentration pick-up unit and data processing method thereof.

Background technology

Blood sugar concentration is one of human body important indicator, and the size of blood sugar concentration is significant to the diagnosis of diabetes, treatment, prognosis.

The Cleaning Principle of portable blood sugar test device main at present mainly contains two kinds: a kind of based on electrochemical method, another is the method based on optics.Electrochemical blood sugar detecting method applies certain voltage in the blood meeting generation current after enzyme reaction, and the size of electric current can increase along with the increase of the blood sugar concentration in blood.By accurately measuring these weak currents, and according to the relation of current value and blood sugar concentration, record blood sugar concentration.Although this method is widely used, and accept by masses.But this method need get a blood from finger tip owing to often surveying a blood sugar concentration, if desired detects blood sugar concentration for a long time, can cause damage to finger tip, also may occur infecting, but diabetes patient is had to again measure every day.Thus there has been proposed optical method for measuring blood sugar concentration, carrying out detection based on optical means to blood sugar is a kind of Non-invasive detection, but due to individual difference too large, the blood sugar concentration that optical means detects exists that to measure individual error large, the shortcomings such as measuring accuracy is not high.

Summary of the invention

In order to solve the problem, the present invention proposes a kind of individuation blood sugar concentration pick-up unit and data processing method thereof, for different individualities, combined with electrochemical and measuring method, adopt partial least square method to carry out matching, and according to the parameter that the external world such as body temperature, environment temperature is measured, calculate blood sugar concentration accurately, reduce the wound to user, reduce the risk of wound infection, overcome the problems such as optical measurement individual error is large, measuring accuracy is not high simultaneously.

For achieving the above object, the concrete technical scheme that the present invention adopts is as follows:

A kind of individuation blood sugar concentration pick-up unit, it is characterized in that, comprise Electrochemical blood glucose acquisition module and Optical blood glucose acquisition module, described Electrochemical blood glucose acquisition module comprises reference voltage output unit, current/voltage converting unit, the first numerical control amplifying unit and the first filter processing unit, and described Optical blood glucose acquisition module comprises microprocessor control unit, the second filter processing unit, analogue selector unit, LED drive unit, LED light module, light sensor, prime amplifying unit, the 3rd filter processing unit and the second numerical control amplifying unit;

Described reference voltage output unit is for providing the reference voltage needed for test to blood sugar test paper bar, through three electrode tests, its current signal exported is sent in described first numerical control amplifying unit through described current/voltage converting unit, described first numerical control amplifying unit exports the signal after amplifying sends into a described microprocessor control unit A/D sampling end through described first filter processing unit, first control end of described microprocessor control unit is also connected with the control pin of described first numerical control amplifying unit, for controlling the signal amplification factor of described first numerical control amplifying unit,

The D/A output port of described microprocessor control unit is also connected with the input end of described second filter processing unit, the output terminal of this second filter processing unit connects described analogue selector unit, each road output terminal of described analogue selector unit is connected to the LED light module of LED drive unit and different-waveband, lighted by the LED light module of described analogue selector Unit selection different-waveband, described light sensor is for receiving optical signal transmissive, this optical signal transmissive is successively through described prime amplifying unit, the 2nd A/D sampling end of described microprocessor control unit is sent into after 3rd filter processing unit and the second numerical control amplifying unit, second control end of described microprocessor control unit is also connected with the control pin of described analogue selector unit, LED light module for controlling described analogue selector Unit selection different-waveband is lighted, 3rd control end of described microprocessor control unit is also connected with the control pin of described second numerical control amplifying unit, for controlling the signal amplification factor of described second numerical control amplifying unit,

Described microprocessor control unit is also connected with temperature sensor unit and reference voltage unit.

Further description, in order to the connection that realizes the two be separated, be provided with interface unit between described Electrochemical blood glucose acquisition module and described Optical blood glucose acquisition module.

Further describing, in order to realize the communication with other equipment, described microprocessor control unit being connected with blue teeth wireless Transmit-Receive Unit; In order to various information displaying can be allowed, described microprocessor control unit is connected with and touch LCD liquid crystal display.

Further describe, described microprocessor control unit is made up of 32-bit microprocessor STM32F415RG and corresponding peripheral cell.

Further describe, described second numerical control amplifying unit is made up of programmable gain amplifier PGA112 and peripheral cell, realizes the control of 1,2,4,8,16,64 and 128 several enlargement factors, to reach the precision of maximum measurement.

In conjunction with above-mentioned individuation blood sugar concentration pick-up unit, the invention allows for a kind of data processing method of individuation blood sugar concentration pick-up unit, carry out according to following steps:

S1: control both optical blood sugar acquisition module carries out Optical blood glucose detection, wherein LED light module uses ultraviolet-visible-near infrared spectrometer in the interscan of 200nm-2500nm scope, obtains the change of a series of absorption light intensity blood sugar concentration be greater than the wavelength of 90% and absorb the wavelength that the change of light intensity blood sugar concentration is less than 5% by light sensor;

S2: the data obtained according to S1, is greater than the wavelength of 90% from the change of absorption light intensity blood sugar concentration respectively and selects 1-3 kind wavelength, and is less than the wavelength of 5% from the change of absorption light intensity blood sugar concentration and selects 1-3 kind wavelength;

S3: the test light that the light of the 2-6 kind different wave length utilizing S2 to obtain detects as Optical blood glucose, obtains transmitted light intensity and the ratio of incident intensity and the pulse wave signal of corresponding wavelength, serviceability temperature sensor acquisition body temperature and environment temperature;

S4: control Electrochemical blood glucose acquisition module and carry out electricity blood sugar test, measure its corresponding blood sugar concentration;

S5: use partial least square method, is detected by repeatedly Electrochemical blood glucose and the data of Optical blood glucose detection gained, carries out data fitting according to the following formula:

$\begin{array}{c}y*=c_0+\underset{i=1}{\overset{M}{\Σ}}{c}_{2i-1}{P}_i+\underset{i=1}{\overset{M}{\Σ}}{c}_{2i}{P}_i^2+\underset{i=1}{\overset{N}{\Σ}}{k}_{2i-1}{R}_{\max i}+\underset{i=1}{\overset{N}{\Σ}}{k}_{2i}{R_{\max i}}^2\\ +\underset{i=1}{\overset{N}{\Σ}}{l}_{2i-1}{R}_{\min i}+\underset{i=1}{\overset{N}{\Σ}}{l}_{2i}{R_{\min i}}^2+c_{Tb}{T}_b+{c_{Tb}}^{\′}{T_b}^2+c_{Tc}{T}_c+{c_{Tc}}^{\′}{T_c}^2\end{array}$

Wherein: y* is the blood glucose concentration value simulated, M is the total number of characteristic parameter of the pulse wave that 2-6 kind wavelength obtains, P _ibe the value of i-th characteristic parameter, N is total number of test light, R _maxibe that i-th incident light and transmitted light ratio are beaten the common logarithm value of mean value of maximal value within 3-50 pulsation period at every turn, R _minibe that i-th incident light and transmitted light ratio are beaten the common logarithm value of mean value of minimum value within 3-50 pulsation period at every turn, T _bfor body temperature, T _cfor environment temperature, c ₀, c _2i-1, c _2i, k _2i-1, k _2i, l _2i-1, l _2i, c _tb, c _tb', c _tc, c _tc' being respectively fitting coefficient corresponding to parameters, the blood glucose concentration value making to simulate by adjusting each fitting coefficient equals the blood glucose concentration value that Electrochemical blood glucose detects;

S6: the fitting coefficient utilizing S5 gained, the test light that the light of the 2-6 kind different wave length directly utilizing S2 to obtain detects as Optical blood glucose, by parameter corresponding in extraction step S5, directly calculates blood glucose concentration value.

Further describe, the characteristic parameter of described pulse wave comprises time domain charactreristic parameter and frequency domain character parameter again.

Remarkable result of the present invention is: for different individualities, combined with electrochemical and measuring method, partial least square method is adopted to carry out matching, and according to the parameter that the external world such as body temperature, environment temperature is measured, calculate blood sugar concentration accurately, greatly reduce finger tip and get blood number of times, reduce the wound to user, reduce the risk of wound infection, overcome the problems such as optical measurement individual error is large, measuring accuracy is not high simultaneously.

Accompanying drawing explanation

Below in conjunction with drawings and Examples, the present invention is further described.

Fig. 1 is structured flowchart of the present invention.

Embodiment

Below in conjunction with accompanying drawing, the specific embodiment of the present invention and principle of work are described in further detail.

As Fig. 1 can find out, a kind of individuation blood sugar concentration pick-up unit, comprise Electrochemical blood glucose acquisition module and Optical blood glucose acquisition module, Electrochemical blood glucose acquisition module comprises reference voltage output unit, current/voltage converting unit, the first numerical control amplifying unit and the first filter processing unit, and Optical blood glucose acquisition module comprises microprocessor control unit, the second filter processing unit, analogue selector unit, LED drive unit, LED light module, light sensor, prime amplifying unit, the 3rd filter processing unit and the second numerical control amplifying unit;

Reference voltage output unit is for providing the reference voltage needed for test to blood sugar test paper bar, through three electrode tests, its current signal exported is sent in the first numerical control amplifying unit through current/voltage converting unit, first numerical control amplifying unit exports the signal after amplifying sends into a microprocessor control unit A/D sampling end through the first filter processing unit, first control end of microprocessor control unit is also connected with the control pin of the first numerical control amplifying unit, for controlling the signal amplification factor of the first numerical control amplifying unit;

The D/A output port of microprocessor control unit is also connected with the input end of the second filter processing unit, the output terminal connecting analog selector unit of this second filter processing unit, each road output terminal of analogue selector unit is connected to the LED light module of LED drive unit and different-waveband, lighted by the LED light module of analogue selector Unit selection different-waveband, light sensor is for receiving optical signal transmissive, this optical signal transmissive is successively through prime amplifying unit, the 2nd A/D sampling end of microprocessor control unit is sent into after 3rd filter processing unit and the second numerical control amplifying unit, second control end of microprocessor control unit is also connected with the control pin of analogue selector unit, the LED light module of different-waveband is selected to light for control simulation selector unit, 3rd control end of microprocessor control unit is also connected with the control pin of the second numerical control amplifying unit, for controlling the signal amplification factor of the second numerical control amplifying unit,

Microprocessor control unit is also connected with temperature sensor unit and reference voltage unit.

It can also be seen that from Fig. 1, in order to realize connection between Electrochemical blood glucose acquisition module and Optical blood glucose acquisition module and be separated, thus realize the effect that Electrochemical blood glucose acquisition module plays correction in measuring process, between Electrochemical blood glucose acquisition module and Optical blood glucose acquisition module, be provided with interface unit.

It can also be seen that from Fig. 1, in order to realize transmitting with the communication of other equipment and data, microprocessor control unit being connected with blue teeth wireless Transmit-Receive Unit; In order to various information displaying can be allowed, microprocessor control unit is connected with and touch LCD liquid crystal display.

In implementation process, that microprocessor control unit is selected is 32-bit microprocessor STM32F415RG, and is connected with corresponding peripheral cell on this microprocessor.

In the present embodiment, the first numerical control amplifying unit and the second numerical control amplifying unit all adopt programmable gain amplifier PGA112 and peripheral cell to form, and realize the control of 1,2,4,8,16,64 and 128 several enlargement factors, to reach the precision of maximum measurement.

The data processing method of above-mentioned individuation blood sugar concentration pick-up unit, carry out according to following steps:

S1: control both optical blood sugar acquisition module carries out Optical blood glucose detection, wherein LED light module uses ultraviolet-visible-near infrared spectrometer in the interscan of 200nm-2500nm scope, obtains the change of a series of absorption light intensity blood sugar concentration be greater than the wavelength of 90% and absorb the wavelength that the change of light intensity blood sugar concentration is less than 5% by light sensor;

S2: the data obtained according to S1, is greater than the wavelength of 90% from the change of absorption light intensity blood sugar concentration respectively and selects 1-3 kind wavelength, and is less than the wavelength of 5% from the change of absorption light intensity blood sugar concentration and selects 1-3 kind wavelength;

S3: the test light that the light of the 2-6 kind different wave length utilizing S2 to obtain detects as Optical blood glucose, obtains transmitted light intensity and the ratio of incident intensity and the pulse wave signal of corresponding wavelength, serviceability temperature sensor acquisition body temperature and environment temperature;

S4: control Electrochemical blood glucose acquisition module and carry out electricity blood sugar test, measure its corresponding blood sugar concentration;

S5: use partial least square method, is detected by repeatedly Electrochemical blood glucose and the data of Optical blood glucose detection gained, carries out data fitting according to the following formula:

$\begin{array}{c}y*=c_0+\underset{i=1}{\overset{M}{\Σ}}{c}_{2i-1}{P}_i+\underset{i=1}{\overset{M}{\Σ}}{c}_{2i}{P}_i^2+\underset{i=1}{\overset{N}{\Σ}}{k}_{2i-1}{R}_{\max i}+\underset{i=1}{\overset{N}{\Σ}}{k}_{2i}{R_{\max i}}^2\\ +\underset{i=1}{\overset{N}{\Σ}}{l}_{2i-1}{R}_{\min i}+\underset{i=1}{\overset{N}{\Σ}}{l}_{2i}{R_{\min i}}^2+c_{Tb}{T}_b+{c_{Tb}}^{\′}{T_b}^2+c_{Tc}{T}_c+{c_{Tc}}^{\′}{T_c}^2\end{array}$

Wherein: y* is the blood glucose concentration value simulated, M is the total number of characteristic parameter of the pulse wave that 2-6 kind wavelength obtains, P _ibe the value of i-th characteristic parameter, N is total number of test light, R _maxibe that i-th incident light and transmitted light ratio are beaten the common logarithm value of mean value of maximal value within 3-50 pulsation period at every turn, R _minibe that i-th incident light and transmitted light ratio are beaten the common logarithm value of mean value of minimum value within 3-50 pulsation period at every turn, T _bfor body temperature, T _cfor environment temperature, c ₀for the Fitting Calculation coefficient, c _2i-1be the design factor of i-th characteristic parameter, c _2ibe the quadratic power design factor of i-th characteristic parameter, k _2i-1for R _maxifirst power design factor, k _2ifor R _maxiquadratic power design factor, l _2i-1for R _minifirst power design factor, l _2ifor R _miniquadratic power design factor, c _tbfor body temperature T _bthe design factor of first power, c _tb' be body temperature T _bthe design factor of quadratic power, T _cfor environment temperature, c _tcfor the design factor of the first power of environment temperature, c _tc' be the design factor of the quadratic power of environment temperature, the blood glucose concentration value making to simulate by adjusting each fitting coefficient equals the blood glucose concentration value that Electrochemical blood glucose detects;

S6: the fitting coefficient utilizing S5 gained, the test light that the light of the 2-6 kind different wave length directly utilizing S2 to obtain detects as Optical blood glucose, by parameter corresponding in extraction step S5, directly calculates blood glucose concentration value.

Further describe, the characteristic parameter of pulse wave comprises time domain charactreristic parameter and frequency domain character parameter again.

Partial least square method concrete grammar is:

If the blood glucose concentration value simulated is y*, then its expression formula is:

$\begin{array}{c}y*=c_0+\underset{i=1}{\overset{M}{\Σ}}{c}_{2i-1}{P}_i+\underset{i=1}{\overset{M}{\Σ}}{c}_{2i}{P}_i^2+\underset{i=1}{\overset{N}{\Σ}}{k}_{2i-1}{R}_{\max i}+\underset{i=1}{\overset{N}{\Σ}}{k}_{2i}{R_{\max i}}^2\\ +\underset{i=1}{\overset{N}{\Σ}}{l}_{2i-1}{R}_{\min i}+\underset{i=1}{\overset{N}{\Σ}}{l}_{2i}{R_{\min i}}^2+c_{Tb}{T}_b+{c_T}^{\′}{T_b}^2+c_{Tc}{T}_c+{c_{Tc}}^{\′}{T_c}^2\end{array}---\left(1\right)$

In formula, y* is the blood glucose concentration value simulated, and M is the total number of characteristic parameter of the pulse wave that 2-6 kind wavelength obtains, P _ibe the value of i-th characteristic parameter, N is total number of test light, R _maxibe that i-th incident light and transmitted light ratio are beaten the common logarithm value of mean value of maximal value within 3-50 pulsation period at every turn, R _minibe that i-th incident light and transmitted light ratio are beaten the common logarithm value of mean value of minimum value within 3-50 pulsation period at every turn, T _bfor body temperature, T _cfor environment temperature, c ₀for the Fitting Calculation coefficient, c _2i-1be the design factor of i-th characteristic parameter, c _2ibe the quadratic power design factor of i-th characteristic parameter, k _2i-1for R _maxifirst power design factor, k _2ifor R _maxiquadratic power design factor, l _2i-1for R _minifirst power design factor, l _2ifor R _miniquadratic power design factor, c _tbfor body temperature T _bthe design factor of first power, c _tb' be body temperature T _bthe design factor of quadratic power, T _cfor environment temperature, c _tcfor the design factor of the first power of environment temperature, c _tc' be the design factor of the quadratic power of environment temperature.

For convenience, x is made ₀=1, x _2i-1=R _i, x _2i=(R _i) ², x _2i-1+2M=R _maxi, x _2i+2M=R _maxi ², x _{2i-1+2 (M+N)}=R _mini, x _{2i+2 (M+N)}=R _mini ², x _{2 (M+2N)+1}=T _b, x _{2 (M+2N)+2}=T _b ², x _{2 (M+2N)+3}=T _c, x _{2 (M+2N)+4}=T _c ², coefficient corresponding before it uses a successively _irepresent, then formula (1) can expression formula can be abbreviated as:

$y^{*}=a_0{x}_0+a_1{x}_1+a_2{x}_2+\mathrm{...}+a_{2(M+2N+2)}{x}_{2(M+2N+2)}=\underset{i=0}{\overset{2(M+2N+2)}{\Σ}}{a}_i{x}_i$

If make L=2 (M+2N+2), then above formula can be abbreviated as further:

$y^{*}=\underset{i=0}{\overset{L}{\Σ}}{a}_i{x}_i---\left(2\right)$

Reality represents by Electrochemical blood glucose acquisition module or by the blood sugar concentration that other electrochemical blood glucose meter records with y, measures K (K>20) altogether secondary, use y to same person _mrepresent actual in Electrochemical blood glucose acquisition module or m blood glucose concentration value being obtained by other electrochemical blood glucose meter, y _m ^*represent the blood glucose concentration value of m data matching, then its difference δ _m=| y _m-y _m ^*|, wherein y _m ^*can be expressed as:

${y_m}^{*}=\underset{i=0}{\overset{L}{\Σ}}{a}_i{x}_{im}$

Principle according to partial least square method will make minimum, namely $\underset{m=1}{\overset{N}{\Σ}}{(y_m-y_m*)}^2=\underset{m=1}{\overset{N}{\Σ}}{(y_m-\underset{i=0}{\overset{L}{\Σ}}{a}_i{x}_{im})}^2$ Minimum.Then have:

$\frac{\∂\[\underset{m=1}{\overset{N}{\Σ}}{(y_m-\underset{i=1}{\overset{L}{\Σ}}{a}_i{x}_{im})}^2\]}{\∂a_k}=0(k=0,...,L)$

That is: $-\underset{m=1}{\overset{N}{\Σ}}2(y_m-\underset{i=0}{\overset{L}{\Σ}}{a}_i{x}_{im})x_{km}=0;$ Have after arrangement:

$\underset{m=1}{\overset{N}{\Σ}}\left(\underset{i=0}{\overset{L}{\Σ}}{a}_i{x}_{im}\right)x_{km}=\underset{m=1}{\overset{N}{\Σ}}{y}_m{x}_{km};$ Wherein (k=0 ..., L) and (3)

Because

$\underset{m=1}{\overset{N}{\Σ}}\left(\underset{i=0}{\overset{L}{\Σ}}{a}_i{x}_{im}\right)x_{km}=\underset{m=1}{\overset{N}{\Σ}}\left(\underset{i=0}{\overset{L}{\Σ}}{a}_i{x}_{im}{x}_{km}\right)=\underset{i=0}{\overset{L}{\Σ}}\left(\underset{m=1}{\overset{N}{\Σ}}{a}_i{x}_{im}{x}_{km}\right)=\underset{i=0}{\overset{L}{\Σ}}{a}_i\left(\underset{m=1}{\overset{N}{\Σ}}{x}_{im}{x}_{km}\right)$

, so formula (3) can arrange be:

wherein (k=0 ..., L), also can be write as

$\left\{\begin{array}{c}\underset{m=1}{\overset{N}{\Σ}}{x}_{0m}{x}_{0m}{a}_0+\underset{m=1}{\overset{N}{\Σ}}{x}_{1m}{x}_{0m}{a}_1+\underset{m=1}{\overset{N}{\Σ}}{x}_{2m}{x}_{0m}{a}_2+\mathrm{...}+\underset{m=1}{\overset{N}{\Σ}}{x}_{Lm}{x}_{0m}{a}_L=\underset{m=1}{\overset{N}{\Σ}}{y}_m{x}_{0m}\\ \underset{m=1}{\overset{N}{\Σ}}{x}_{0m}{x}_{1m}{a}_0+\underset{m=1}{\overset{N}{\Σ}}{x}_{1m}{x}_{1m}{a}_1+\underset{m=1}{\overset{N}{\Σ}}{x}_{2m}{x}_{1m}{a}_2+\mathrm{...}+\underset{m=1}{\overset{N}{\Σ}}{x}_{Lm}{x}_{1m}{a}_L=\underset{m=1}{\overset{N}{\Σ}}{y}_m{x}_{1m}\\ \mathrm{...}\\ \underset{m=1}{\overset{N}{\Σ}}{x}_{0m}{x}_{Lm}{a}_0+\underset{m=1}{\overset{N}{\Σ}}{x}_{1m}{x}_{Lm}{a}_1+\underset{m=1}{\overset{N}{\Σ}}{x}_{2m}{x}_{L)m}{a}_2+\mathrm{...}+\underset{m=1}{\overset{N}{\Σ}}{x}_{Lm}{x}_{Lm}{a}_L=\underset{m=1}{\overset{N}{\Σ}}{y}_m{x}_{Lm}\end{array}\right.$

An above-mentioned L+1 equation is brought into each N number of data recorded, solves a ₀, a ₁a ₂, a _l, then can obtain multivariable fitting function, then can obtain multivariable fitting function

$y^{*}=a_0{x}_0+a_1{x}_1+a_2{x}_2+...+a_L{x}_L=\underset{i=0}{\overset{L}{\Σ}}{a}_L{x}_L$

By the x of above-mentioned order ₀=1, x _2i-1=R _i, x _2i=(R _i) ², x _2i-1+2M=R _maxi, x _2i+2M=R _maxi ², x _{2i-1+2 (M+N)}=R _mini, x _{2i+2 (M+N)}=R _mini ², x _{2 (M+2N)+1}=T _b, x _{2 (M+2N)+2}=T _b ², x _{2 (M+2N)+3}=T _c, x _{2 (M+2N)+4}=T _c ²bring into and can obtain:

$\begin{array}{c}y*=c_0+\underset{i=1}{\overset{M}{\Σ}}{c}_{2i-1}{P}_i+\underset{i=1}{\overset{M}{\Σ}}{c}_{2i}{P}_i^2+\underset{i=1}{\overset{N}{\Σ}}{k}_{2i-1}{R}_{\max i}+\underset{i=1}{\overset{N}{\Σ}}{k}_{2i}{R_{\max i}}^2\\ +\underset{i=1}{\overset{N}{\Σ}}{l}_{2i-1}{R}_{\min i}+\underset{i=1}{\overset{N}{\Σ}}{l}_{2i}{R_{\min i}}^2+c_{Tb}{T}_b+{c_T}^{\′}{T_b}^2+c_{Tc}{T}_c+{c_{Tc}}^{\′}{T_c}^2\end{array}$

Utilize partial least square method, matching obtains coefficient, and in conjunction with the body temperature T of actual measurement _b, environment temperature T _c, i-th incident light and transmitted light ratio beats the common logarithm value R of mean value of maximal value within 3-50 pulsation period at every turn _maxi, i-th incident light and transmitted light ratio beats the common logarithm value R of mean value of minimum value within 3-50 pulsation period at every turn _mini, calculate matching blood glucose concentration value, be finally reached through the blood glucose concentration value that each fitting coefficient of adjustment makes the blood glucose concentration value simulated equal Electrochemical blood glucose to detect.

By above-mentioned design, Electrochemical blood glucose acquisition module and Optical blood glucose acquisition module are combined, blood sugar test is carried out for individuality, often carry out the collection of primary electrochemical blood sugar just once to revise Optical blood glucose collection, after constantly revising, it is final that only need carry out electrochemical method once in a while carries out blood sugar concentration detection, and then adopt noninvasive optical means to carry out the detection of blood sugar concentration, the number of times that finger tip gets blood can be greatly reduced, the degree making noninvasive optical means carry out blood sugar test to reach practical.

Claims (7)

1. an individuation blood sugar concentration pick-up unit, it is characterized in that, comprise Electrochemical blood glucose acquisition module and Optical blood glucose acquisition module, described Electrochemical blood glucose acquisition module comprises reference voltage output unit, current/voltage converting unit, the first numerical control amplifying unit and the first filter processing unit, and described Optical blood glucose acquisition module comprises microprocessor control unit, the second filter processing unit, analogue selector unit, LED drive unit, LED light module, light sensor, prime amplifying unit, the 3rd filter processing unit and the second numerical control amplifying unit;

Described reference voltage output unit is for providing the reference voltage needed for test to blood sugar test paper bar, through three electrode tests, its current signal exported is sent in described first numerical control amplifying unit through described current/voltage converting unit, described first numerical control amplifying unit exports the signal after amplifying sends into a described microprocessor control unit A/D sampling end through described first filter processing unit, first control end of described microprocessor control unit is also connected with the control pin of described first numerical control amplifying unit, for controlling the signal amplification factor of described first numerical control amplifying unit,

The D/A output port of described microprocessor control unit is also connected with the input end of described second filter processing unit, the output terminal of this second filter processing unit connects described analogue selector unit, each road output terminal of described analogue selector unit is connected to the LED light module of LED drive unit and different-waveband, lighted by the LED light module of described analogue selector Unit selection different-waveband, described light sensor is for receiving optical signal transmissive, this optical signal transmissive is successively through described prime amplifying unit, the 2nd A/D sampling end of described microprocessor control unit is sent into after 3rd filter processing unit and the second numerical control amplifying unit, second control end of described microprocessor control unit is also connected with the control pin of described analogue selector unit, LED light module for controlling described analogue selector Unit selection different-waveband is lighted, 3rd control end of described microprocessor control unit is also connected with the control pin of described second numerical control amplifying unit, for controlling the signal amplification factor of described second numerical control amplifying unit,

Described microprocessor control unit is also connected with temperature sensor unit and reference voltage unit.

2. a kind of individuation blood sugar concentration pick-up unit according to claim 1, is characterized in that: be provided with interface unit between described Electrochemical blood glucose acquisition module and described Optical blood glucose acquisition module, for the connection that realizes the two be separated.

3. a kind of individuation blood sugar concentration pick-up unit according to claim 1, is characterized in that: in described microprocessor control unit, be also connected with blue teeth wireless Transmit-Receive Unit and touch LCD liquid crystal display.

4., according to the arbitrary described a kind of individuation blood sugar concentration pick-up unit of claim 1-3, it is characterized in that: described microprocessor control unit is made up of 32-bit microprocessor STM32F415RG and corresponding peripheral cell.

5. a kind of individuation blood sugar concentration pick-up unit according to claim 1, is characterized in that: described first numerical control amplifying unit and described second numerical control amplifying unit all adopt programmable gain amplifier PGA112 and peripheral cell to form.

6., based on a data processing method for individuation blood sugar concentration pick-up unit according to claim 1, it is characterized in that carrying out according to following steps:

S1: control both optical blood sugar acquisition module carries out Optical blood glucose detection, wherein LED light module uses ultraviolet-visible-near infrared spectrometer in the interscan of 200nm-2500nm scope, obtains the change of a series of absorption light intensity blood sugar concentration be greater than the wavelength of 90% and absorb the wavelength that the change of light intensity blood sugar concentration is less than 5% by light sensor;

S2: the data obtained according to S1, is greater than the wavelength of 90% from the change of absorption light intensity blood sugar concentration respectively and selects 1-3 kind wavelength, and is less than the wavelength of 5% from the change of absorption light intensity blood sugar concentration and selects 1-3 kind wavelength;

S3: the test light that the light of the 2-6 kind different wave length utilizing S2 to obtain detects as Optical blood glucose, obtains transmitted light intensity and the ratio of incident intensity and the pulse wave signal of corresponding wavelength, serviceability temperature sensor acquisition body temperature and environment temperature;

S4: control Electrochemical blood glucose acquisition module and carry out electricity blood sugar test, measure its corresponding blood sugar concentration;

S5: use partial least square method, is detected by repeatedly Electrochemical blood glucose and the data of Optical blood glucose detection gained, carries out data fitting according to the following formula:

$\begin{array}{c}y*=c_0+\underset{i=1}{\overset{M}{\Σ}}{c}_{2i-1}{P}_i+\underset{i=1}{\overset{M}{\Σ}}{c}_{2i}{P}_i^2+\underset{i=1}{\overset{N}{\Σ}}{k}_{2i-1}{R}_{\max i}+\underset{i=1}{\overset{N}{\Σ}}{k}_{2i}{R_{\max i}}^2\\ +\underset{i=1}{\overset{N}{\Σ}}{l}_{2i-1}{R}_{\min i}+\underset{i=1}{\overset{N}{\Σ}}{l}_{2i}{R_{\min i}}^2+c_{Tb}{T}_b+{c_{Tb}}^{\′}{T_b}^2+c_{Tc}{T}_c+{c_{Tc}}^{\′}{T_c}^2\end{array}$

Wherein: y* is the blood glucose concentration value simulated, M is the total number of characteristic parameter of the pulse wave that 2-6 kind wavelength obtains, P _ibe the value of i-th characteristic parameter, N is total number of test light, R _maxibe that i-th incident light and transmitted light ratio are beaten the common logarithm value of mean value of maximal value within 3-50 pulsation period at every turn, R _minibe that i-th incident light and transmitted light ratio are beaten the common logarithm value of mean value of minimum value within 3-50 pulsation period at every turn, T _bfor body temperature, T _cfor environment temperature, c ₀, c _2i-1, c _2i, k _2i-1, k _2i, l _2i-1, l _2i, c _tb, c _tb', c _tc, c _tc' being respectively fitting coefficient corresponding to parameters, the blood glucose concentration value making to simulate by adjusting each fitting coefficient equals the blood glucose concentration value that Electrochemical blood glucose detects;

S6: the fitting coefficient utilizing S5 gained, the test light that the light of the 2-6 kind different wave length directly utilizing S2 to obtain detects as Optical blood glucose, by parameter corresponding in extraction step S5, directly calculates blood glucose concentration value.

7. the data processing method of individuation blood sugar concentration pick-up unit according to claim 6, is characterized in that: the characteristic parameter of described pulse wave comprises time domain charactreristic parameter and frequency domain character parameter.