CN105079811B - 结合阿片类药物使用棕榈酰基乙醇酰胺 - Google Patents

结合阿片类药物使用棕榈酰基乙醇酰胺 Download PDF

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Publication number
CN105079811B
CN105079811B CN201510243856.6A CN201510243856A CN105079811B CN 105079811 B CN105079811 B CN 105079811B CN 201510243856 A CN201510243856 A CN 201510243856A CN 105079811 B CN105079811 B CN 105079811B
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opioid
palmitoyl ethanolamide
palmitoyl
treatment
use according
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Chinese (zh)
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CN105079811A (zh
Inventor
瓦莱 弗朗切斯科·德拉
瓦莱 玛丽亚·费代丽卡·德拉
切萨雷 马内利 洛伦佐·迪
卡拉·盖拉尔迪尼
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Epitech Group SpA
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/164Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4468Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Dispersion Chemistry (AREA)
CN201510243856.6A 2014-05-14 2015-05-13 结合阿片类药物使用棕榈酰基乙醇酰胺 Active CN105079811B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI20140876 2014-05-14
ITMI2014A000876 2014-05-14

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CN105079811A CN105079811A (zh) 2015-11-25
CN105079811B true CN105079811B (zh) 2020-06-23

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US (1) US9801836B2 (enExample)
EP (1) EP2944309B1 (enExample)
JP (1) JP6563685B2 (enExample)
KR (1) KR102507891B1 (enExample)
CN (1) CN105079811B (enExample)
AR (1) AR100444A1 (enExample)
AU (1) AU2015202575B9 (enExample)
BR (1) BR102015011079A2 (enExample)
CA (1) CA2891049C (enExample)
CY (1) CY1121773T1 (enExample)
DK (1) DK2944309T3 (enExample)
ES (1) ES2731729T3 (enExample)
HU (1) HUE044915T2 (enExample)
PL (1) PL2944309T3 (enExample)
PT (1) PT2944309T (enExample)
SM (1) SMT201900345T1 (enExample)
TR (1) TR201908936T4 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL322263A (en) * 2015-05-21 2025-09-01 Scisparc Ltd Combinations of opioids and acetylamines
PH12018000077B1 (en) 2017-07-05 2021-07-09 Frimline Private Ltd A pharmaceutical composition for neuropathic pain
PH12018000227A1 (en) 2017-09-05 2019-03-11 Frimline Private Ltd A pharmaceutical composition for improving or preventing progression of chronic kidney disease
WO2020141546A1 (en) * 2019-01-02 2020-07-09 Celagenex Research (India) Pvt. Ltd. Synergistic nutritional compositions for pain management

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005107726A2 (en) * 2004-04-27 2005-11-17 Pain Therapeutics, Inc. Method for the treatment of back pain
CN102186459A (zh) * 2009-09-07 2011-09-14 晶源集团股份责任有限公司 含有超微粒化十六酰胺乙醇的组合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1271266B (it) 1994-12-14 1997-05-27 Valle Francesco Della Impiego terapeutico di ammidi di acidi mono e bicarbossilici con amminoalcoli,selettivamente attive sul recettore periferico dei cannabinoidi
US6548550B1 (en) 1999-08-06 2003-04-15 Innovet Italia S.R.L. Pharmaceutical compositions containing N-palmitoylethanolamide and use thereof in the veterinary field
ES2312643T5 (es) * 2001-07-18 2011-10-18 Unilever N.V. Composiciones para el tratamiento del cabello y/o del cuero cabelludo.
JP2012522004A (ja) * 2009-03-27 2012-09-20 アボット・ラボラトリーズ カンナビノイド受容体リガンドである化合物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005107726A2 (en) * 2004-04-27 2005-11-17 Pain Therapeutics, Inc. Method for the treatment of back pain
CN102186459A (zh) * 2009-09-07 2011-09-14 晶源集团股份责任有限公司 含有超微粒化十六酰胺乙醇的组合物

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Publication number Publication date
KR102507891B1 (ko) 2023-03-08
AR100444A1 (es) 2016-10-05
KR20150130931A (ko) 2015-11-24
CA2891049C (en) 2023-02-21
CA2891049A1 (en) 2015-11-14
DK2944309T3 (da) 2019-06-03
BR102015011079A2 (pt) 2016-03-29
PL2944309T3 (pl) 2019-09-30
CN105079811A (zh) 2015-11-25
PT2944309T (pt) 2019-06-05
AU2015202575A1 (en) 2015-12-03
JP6563685B2 (ja) 2019-08-21
AU2015202575B9 (en) 2020-03-26
US20150328173A1 (en) 2015-11-19
HUE044915T2 (hu) 2019-11-28
SMT201900345T1 (it) 2019-07-11
US9801836B2 (en) 2017-10-31
TR201908936T4 (tr) 2019-07-22
AU2015202575B2 (en) 2020-03-05
CY1121773T1 (el) 2020-07-31
ES2731729T3 (es) 2019-11-18
EP2944309A1 (en) 2015-11-18
JP2015221794A (ja) 2015-12-10
EP2944309B1 (en) 2019-03-20

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