CN105079436A - Biological agent with myocardial ischemia prevention and treatment function and anti-hypoxia function and preparation method of biological agent - Google Patents
Biological agent with myocardial ischemia prevention and treatment function and anti-hypoxia function and preparation method of biological agent Download PDFInfo
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Abstract
The invention relates to a biological agent with a myocardial ischemia prevention and treatment function and an anti-hypoxia function and a preparation method of the biological agent. The preparation method comprises steps as follows: raw materials in percentage by weight comprising 15%-20% of marigold, 10%-20% of white peony root, 10%-20% of hawthorn fruit, 10%-20% of radix puerariae, 10%-20% of ophiopogon japonicus, 10%-20% of panax notoginseng, 5%-15% of rhodiola rosea and 5%-10% of pomelos, 5%-10% of green tea are weighed, an ethanol solution accounting for 8-12 times of the weight of the raw materials is added, the mixture is stirred, mixed and subjected to reflux extraction, an extracting solution is subjected to vacuum concentration, and a concentrated solution A is obtained; 6-10 parts by weight of deionized water is added to traditional Chinese medicine residues after reflux extraction with ethanol, the mixture is subjected to reflux extraction, a water extract is subjected to vacuum concentration, and a concentrated solution B is obtained; the concentrated solution A and the concentrated solution B are mixed and subjected to vacuum drying, and the biological agent is prepared. Compared with the prior art, the biological agent has the advantages of myocardial oxygen consumption reduction, myocardial metabolic disturbance improvement, hemodynamic disturbance correction and the like.
Description
Technical field
The present invention relates to coldrex, be specifically related to biological preparation with control myocardial ischemia anoxia tolerance function and preparation method thereof.
Background technology
Along with the change of modern life dietary structure and the change of people's rule of life, people's heart burden becomes large, and health of heart problem is day by day serious.
Myocardial ischemia disease is divided into symptom myocardial ischemia and silent ischemia.Wherein the danger of silent ischemia and sickness rate the highest.It can cause angina pectoris, arrhythmia, pump failure, acute myocardial infarction and sudden death, and it, as a class of coronary heart disease, is subject to the attention of medical circle day by day.
Along with the development of modern medicine, myocardial ischemia in prevention, diagnosis, all achieve development at full speed in treatment, but due to the many and machine-processed complexity of its complication, adds the limitation of medicine, for preventing and controlling bring certain difficulty.The medicines such as nitrate esters, calcium channel blocker, beta-blockers are Be very effective on treatment myocardial ischemia, important effect is had with the quality of life of improving patient to the life extending patient, but also there is limitation in these medicines, such as easily there is toleration in nitrate esters medicine, calcium channel blocker reflexive can cause sympathetic activation, and beta-blockers has harmful effect to blood fat, blood glucose.Therefore, an important research topic is still to the research of the exploration of medicaments for resisting myocardial ischemia and the mechanism of resisting myocardial ischemia.
Myocardial ischemia belongs to Chinese medicine " thoracic obstruction ", " pained " category, and the sick position of primary disease is based on heart kidney, and basic pathogenesis is deficiency in origin and excess in superficiality, deficiency in origin based on internal organs virtual loss, the deficiency of YIN of can holding concurrently; Mark is real common with blood stasis stagnation of phlegm.As mentioned above, the medicine for the treatment of primary disease has certain curative effect at present, but side effect is larger.
Summary of the invention
Object of the present invention is exactly provide a kind of enhancing human body immunity power to overcome defect that above-mentioned prior art exists and have biological preparation of control myocardial ischemia anoxia tolerance function and preparation method thereof.
Object of the present invention can be achieved through the following technical solutions: a kind of biological preparation with control myocardial ischemia anoxia tolerance function, is characterized in that, the component mainly comprising following weight percentage of this biological preparation:
Further preferably, raw material comprises the component of following weight percentage:
Have a preparation method for the biological preparation of control myocardial ischemia anoxia tolerance function, it is characterized in that, the method comprises the following steps:
(1) percentage composition takes raw material Flos Inulae 15-20% by weight; Radix Paeoniae Alba 10-20%; Fructus Crataegi 10-20%; Radix Puerariae 10-20%; Radix Ophiopogonis 10-20%; Radix Notoginseng 10-20%; Radix Rhodiolae 5-15%; Fructus Citri grandis 5-10%; Green tea 5-10%, adds the 8-12 alcoholic solution doubly of raw material weight, is uniformly mixed, reflux, extract, by extracting solution vacuum concentration, obtains concentrated solution A;
(2) by the Chinese medicine residue after alcohol reflux, add 6-10 weight portion deionization, reflux, extract, gained Aqueous extracts vacuum concentration, obtains concentrated solution B;
(3) by concentrated solution A, concentrated solution B mixes, and carries out vacuum drying, obtains this biological preparation.
The temperature of the reflux, extract, described in step (1) is 30-60 DEG C, and number of times is 2-3 time.
The temperature of the vacuum concentration described in step (1) is 50-80 DEG C, and vacuum is 500-700Pa.
The mass concentration of the alcoholic solution described in step (1) is 50-80%.
The density of described concentrated solution A is 1.03-1.06g/cm
3.
The temperature of the reflux, extract, described in step (2) is 50-80 DEG C, and number of times is 2-3 time.
The temperature of the vacuum concentration described in step (2) is 50-80 DEG C, and vacuum is 500-700Pa.
The density of described concentrated solution A is 1.05-10.08g/cm
3.
The raw material that this biological preparation adopts:
Flos Inulae is Compositae Calendula officinalis platymiscium.The short life of Calendula officinalis plant, flower is intensive, and pattern is dazzlingly beautiful, florescence is long again, and polyphyll, volume lobe and the green heart, darkviolet are fickle in love, can be used as medicinal or dyestuff, also can as cosmetic material or food, its leaf and petal edible, therefore can be used as the decoration of dish.The anti-sulfur dioxide of Flos Inulae is very capable, also has certain resistance to cyanide and hydrogen sulfide, and being excellent anti-soil flowers, is also the main material of flower bed in spring, can make cut-flower and potted plant.Flos Inulae is rich in multivitamin, especially vitamin A and vitamin C, can prevent pigementation, promote skin gloss and elasticity, delaying senility, avoid the lax life of skin to wrinkle.Also can prevent ciril disease, as vascular lesion and cancer, more can regulate the flow of vital energy cough-relieving, stomach invigorating, reduce phlegm, prevention of asthma and bronchitis.Almost each position can eat; Its petal has the function of beauty treatment, and flower is containing carotenoid, lycopene, violaxanthin, rubixanthin, volatile oil, resin, lymphatic temperament, malic acid etc.Root contains amaroid, mountain gold east glycol; Seed is containing glyceride, ceryl alcohol and alkaloid.Putting in shampoo to make hair color thin out.
The Radix Paeoniae Alba is the hematonic in Chinese medicine.Meridian distribution of property and flavor: bitter, acid, is slightly cold.Return liver, spleen channel.Efficacy of drugs: enrich blood, yin fluid astringing easing the affected liver, relieving spasm to stop pain.Primary treatment: 1. enrich blood: be used for the treatment of: (1) blood deficiency is uncomfortable through row, dysmenorrhea, metrorrhagia, companion is dizzy weak, palpitation and insomnia.(2) blood deficiency the liver pulse loses and supports, and limbs contraction is anxious, ankylosis, joint stuffiness.2. yin fluid astringing easing the affected liver: be used for the treatment of: (1) calentura later stage cloudy liquid consumption wound, clonic convulsion of the hand and foot, xerostomia is not thirsty, deficient pulse crimson tongue.(2) deficiecny of liver-YIN, excessive rising of liver-YANG, dizzy dizziness, tinnitus, numb limbs and tense tendons.3. relieving spasm to stop pain: be used for the treatment of: (1) gastral cavity abdomen pain in chest and hypochondrium, as deficiency-cold in middle-JIAO, epigastric pain.(2) depression of liver-QI, the pain over the hypochondriac region.(3) deficiency of YIN-blood, shank takes out pain of pulling.In addition, the Radix Paeoniae Alba also can be treated: 1. dysentery, has loose bowels.Dysentery, stomachache, tenesmus.2. spontaneous perspiration, night sweat.
Fructus Crataegi belongs to stone fruit, and caryoplasm is hard, and sarcocarp is thin, and taste is micro-sour and astringent.Fruit is raw-eaten or make preserved fruit fruitcake, can be used as medicine after drying, Chinese distinctive medicine fruit dual-purpose seeds, there is the effects such as blood fat reducing, blood pressure, heart tonifying, arrhythmia, also be simultaneously the good medicine of spleen benefiting and stimulating the appetite, relieving dyspepsia, phlegm reduction of blood circulation promoting, the disease such as, hernia, blood stasis full to chest and diaphragm spleen, amenorrhea has good curative effect.Flavone compound vitexin in Fructus Crataegi is the medicine that a kind of antitumaous effect is stronger, and its extract all has certain effect to growth of cancer cells, propagation and infiltration metastasis in suppression body
Radix Puerariae is the dry root of legume pueraria lobata, practises and claims Herba Gelsemii Elegantis.Autumn, season in winter two excavate, and take advantage of fresh-cut and become sheet or fritter; Dry.Sweet, pungent, cool.There is expelling pathogenic factors from muscles for reducing heat, rash, promoting the production of body fluid to quench thirst, the merit of yang invigorating antidiarrheal.Be usually used in exterior syndrome heating, stiff nape and back, measles without adequate eruption, calentura is thirsty, and the deficiency of YIN is quenched one's thirst, diarrhea of heat type hematodiarrhoea, diarrhea due to hypofunction of the spleen.
Radix Ophiopogonis has YIN nourishing and the production of body fluid promoting, the effect that lung moistening clears away heart-fire.For dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.
Radix Notoginseng is rich in arasaponin, Radix Notoginseng polysaccharide, dencichine, flavone effective ingredient, has the effects such as hemostasis, blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain, strengthening by means of tonics, resisting fatigue, anoxia enduring, defying age, blood fat reducing, blood sugar lowering, raising body's immunity.Can be used for the various inside and outside hemorrhages such as treatment traumatic hemorrhage, blood stasis, gastrorrhagia, hematuria; Blood vessel dilating, thrombus, improves microcirculation, the cardiovascular and cerebrovascular diseases such as prevention and therapy hyperlipidemia, cholesterol increase, coronary heart diseases and angina pectoris, apoplexy sequela; The hepatopathy such as fatty liver, hepatic fibrosis and lose blood, body deficient syndrome that puerperal, the reason such as prolonged illness cause.
Radix Rhodiolae is herbaceos perennial, high 10-20 centimetre.Root is sturdy, conical, and meat is isabelline, and the most fibrous root of collar portion tool, rhizome is short, thick shape, cylindrical, by the lepidiod leaf that most imbricate arranges.Growth is in the high and cold pollution-free area of height above sea level 1800-2500 meters, and its growing environment is severe, thus has very strong vitality and special adaptability.Can do medicinal, have QI invigorating lung heat clearing, Fructus Alpiniae Oxyphyllae is nourished heart, effect of hemostasis with astringents, dissipating blood stasis for subsidence of swelling.Cure mainly deficiency of vital energy and physically weak, after being ill fear of cold, shortness of breath and fatigue, cough due to lung-heat, spitting of blood, leucorrhea diarrhoea, traumatic injury etc.
Fructus Citri grandis contains saccharide, vitamin B1, vitamin B2, vitamin C, Citrin, carotene, potassium, calcium, phosphorus, citric acid etc.Pericarpium Citri grandis main component has naringin, neohesperidin etc., and Semen Citri grandis contains fatty oil, obacunone, obakulactone etc.Fructus Citri grandis is not only of high nutritive value, but also there is stomach invigorating, lung moistening, enrich blood, bowel relieving, the effect such as convenient, wound healing can be promoted, have good auxiliary curative effect to septicemia etc.In addition, because Fructus Citri grandis contains biological active substances skin glycoside, so the viscosity of blood can be reduced, the formation of thrombosis is reduced, so to cerebrovascular disease, as cerebral thrombosis, apoplexy etc. also have good preventive effect.And fresh Fructus Citri grandis meat is due to the composition containing similar insulin, the ultimate food of diabetics especially.
The tea polyphenols that green tea contains, catechin, chlorophyll, caffeine, aminoacid, vitamins and other nutritious components are also more.These natural nutrition compositions in green tea have special-effect to anti-aging, anti-cancer, anticancer, sterilization, antiinflammatory etc.
The above-mentioned raw materials that the present invention adopts, under the condition of preparation method of the present invention, is used for carrying out onset to myocardial ischemia anoxia enduring by too many levels synergism.
Compared with prior art, the present invention has the following advantages:
1. reduce myocardial oxygen consumption, improve myocardial metabolism disorder
2. correct hemodynamic disturbance
3. remove oxygen freedom, anti peroxidation of lipid
4. suppress Ca
2+interior stream
5. regulate Endothelin and nitric oxide balance
6. regulate TXA/PGI
2balance.
Detailed description of the invention
Elaborate to embodiments of the invention below, the present embodiment is implemented under premised on technical solution of the present invention, give detailed embodiment and concrete operating process, but protection scope of the present invention is not limited to following embodiment.
Embodiment 1
Have a preparation method for the biological preparation of control myocardial ischemia anoxia tolerance function, it is characterized in that, the method comprises the following steps:
(1) percentage composition takes raw material Flos Inulae 15% by weight; The Radix Paeoniae Alba 10%; Fructus Crataegi 10%; Radix Puerariae 10%; Radix Ophiopogonis 20%; Radix Notoginseng 10%; Radix Rhodiolae 5%; Fructus Citri grandis 10%; Green tea 10%, adding 8 times of mass concentrations of raw material weight is the alcoholic solution of 50%, is uniformly mixed, and 60 DEG C of reflux, extract, 2 times, by extracting solution at 50 DEG C, vacuum is vacuum concentration under 700Pa, and obtaining density is 1.03g/cm
3concentrated solution A;
(2) by the Chinese medicine residue after alcohol reflux, add 10 weight portion deionizations, 50 DEG C of reflux, extract, 2 times, gained Aqueous extracts is at 50 DEG C, and vacuum is vacuum concentration under 500Pa, and obtaining density is 1.05g/cm
3concentrated solution B;
(3) by concentrated solution A, concentrated solution B mixes, and carries out vacuum drying, obtains this biological preparation.
Embodiment 2
Have a preparation method for the biological preparation of control myocardial ischemia anoxia tolerance function, it is characterized in that, the method comprises the following steps:
(1) percentage composition takes raw material Flos Inulae 20% by weight; The Radix Paeoniae Alba 20%; Fructus Crataegi 15%; Radix Puerariae 10%; Radix Ophiopogonis 10%; Radix Notoginseng 10%; Radix Rhodiolae 5%; Fructus Citri grandis 5%; Green tea 5%, adding 10 times of mass concentrations of raw material weight is the alcoholic solution of 60%, is uniformly mixed, and 30 DEG C of reflux, extract, 3 times, by extracting solution at 80 DEG C, vacuum is vacuum concentration under 500Pa, and obtaining density is 1.06g/cm
3concentrated solution A;
(2) by the Chinese medicine residue after alcohol reflux, add 8 weight portion deionizations, 60 DEG C of reflux, extract, 3 times, gained Aqueous extracts is at 60 DEG C, and vacuum is vacuum concentration under 700Pa, and obtaining density is 5g/cm
3concentrated solution B;
(3) by concentrated solution A, concentrated solution B mixes, and carries out vacuum drying, obtains this biological preparation.
Embodiment 3
Have a preparation method for the biological preparation of control myocardial ischemia anoxia tolerance function, it is characterized in that, the method comprises the following steps:
(1) percentage composition takes raw material Flos Inulae 16% by weight; The Radix Paeoniae Alba 14%; Fructus Crataegi 16%; Radix Puerariae 14%; Radix Ophiopogonis 10%; Radix Notoginseng 10%; Radix Rhodiolae 10%; Fructus Citri grandis 5%; Green tea 5%, adding 12 times of mass concentrations of raw material weight is the alcoholic solution of 70%, is uniformly mixed, and 30 DEG C of reflux, extract, 3 times, by extracting solution at 50 DEG C, vacuum is vacuum concentration under 700Pa, and obtaining density is 1.04g/cm
3concentrated solution A;
(2) by the Chinese medicine residue after alcohol reflux, add 7 weight portion deionizations, 80 DEG C of reflux, extract, 2 times, gained Aqueous extracts is at 50 DEG C, and vacuum is vacuum concentration under 700Pa, and obtaining density is 3g/cm
3concentrated solution B;
(3) by concentrated solution A, concentrated solution B mixes, and carries out vacuum drying, obtains this biological preparation.
Embodiment 4
Have a preparation method for the biological preparation of control myocardial ischemia anoxia tolerance function, it is characterized in that, the method comprises the following steps:
(1) percentage composition takes raw material Flos Inulae 15% by weight; The Radix Paeoniae Alba 10%; Fructus Crataegi 10%; Radix Puerariae 10%; Radix Ophiopogonis 14%; Radix Notoginseng 15%; Radix Rhodiolae 15%; Fructus Citri grandis 5%; Green tea 6%, adding 9 times of mass concentrations of raw material weight is the alcoholic solution of 80%, is uniformly mixed, and 30-60 DEG C of reflux, extract, 2-3 time, by extracting solution at 50-80 DEG C, vacuum is vacuum concentration under 500-700Pa, and obtaining density is 1.03-1.06g/cm
3concentrated solution A;
(2) by the Chinese medicine residue after alcohol reflux, add 8 weight portion deionizations, 70 DEG C of reflux, extract, 2 times, gained Aqueous extracts is at 60 DEG C, and vacuum is vacuum concentration under 600Pa, and obtaining density is 2g/cm
3concentrated solution B;
(3) by concentrated solution A, concentrated solution B mixes, and carries out vacuum drying, obtains this biological preparation.
Embodiment 5
Have a preparation method for the biological preparation of control myocardial ischemia anoxia tolerance function, it is characterized in that, the method comprises the following steps:
(1) percentage composition takes raw material Flos Inulae 15% by weight; The Radix Paeoniae Alba 10%; Fructus Crataegi 14%; Radix Puerariae 20%; Radix Ophiopogonis 16%; Radix Notoginseng 10%; Radix Rhodiolae 5%; Fructus Citri grandis 5%; Green tea 5%, adding 10 times of mass concentrations of raw material weight is the alcoholic solution of 60%, is uniformly mixed, and 30 DEG C of reflux, extract, 3 times, by extracting solution at 50 DEG C, vacuum is vacuum concentration under 500Pa, and obtaining density is 1.06g/cm
3concentrated solution A;
(2) by the Chinese medicine residue after alcohol reflux, add 6 weight portion deionizations, 50 DEG C of reflux, extract, 3 times, gained Aqueous extracts is at 50 DEG C, and vacuum is vacuum concentration under 500Pa, and obtaining density is 1.05g/cm
3concentrated solution B;
(3) by concentrated solution A, concentrated solution B mixes, and carries out vacuum drying, obtains this biological preparation.
Embodiment 6
Have a preparation method for the biological preparation of control myocardial ischemia anoxia tolerance function, it is characterized in that, the method comprises the following steps:
(1) percentage composition takes raw material Flos Inulae 15% by weight; The Radix Paeoniae Alba 10%; Fructus Crataegi 10%; Radix Puerariae 16%; Radix Ophiopogonis 10%; Radix Notoginseng 20%; Radix Rhodiolae 8%; Fructus Citri grandis 6%; Green tea 5%, adding 12 times of mass concentrations of raw material weight is the alcoholic solution of 50-80%, is uniformly mixed, and 60 DEG C of reflux, extract, 2 times, by extracting solution at 80 DEG C, vacuum is vacuum concentration under 700Pa, and obtaining density is 1.06g/cm
3concentrated solution A;
(2) by the Chinese medicine residue after alcohol reflux, add 10 weight portion deionizations, 80 DEG C of reflux, extract, 2 times, gained Aqueous extracts is at 80 DEG C, and vacuum is vacuum concentration under 700Pa, and obtaining density is 10.08g/cm
3concentrated solution B;
(3) by concentrated solution A, concentrated solution B mixes, and carries out vacuum drying, obtains this biological preparation.
This product has carried out animal experiment study for myocardial ischemia anoxia enduring, and result is as follows:
Table 1 rat blood serum CK-MB is active, and CTNT content and left ventricle infarction rate compare
| Group | Number of animals | CK-MK(ku/L) | CTNT(μg/l) | Infarction rate (%) |
| Matched group | 30 | 1.71±0.29 | 4.39±0.97* | 35.28±3.85 |
| Take group | 30 | 0.86±0.31* | 2.19±1.06* | 13.16±3.29* |
The impact of table 2 rat blood serum MDA and SOD
| Group | Number of animals | MDA(nmol/ml) | SOD(u/ml) |
| Matched group | 30 | 3.39±1.03 | 47.9±10.3 |
| Take group | 30 | 2.31±0.68* | 73.6±16.3* |
The impact of table 3 hemorheology of rat
| Group | Number of animals | Packed cell volume | Whole blood contrast viscosity (mPas) | Plasma viscosity (mPas) |
| Matched group | 30 | 0.51±0.03 | 9.2±2.6 | 2.63±0.51 |
| Take group | 30 | 0.43±0.05* | 6.8±1.3* | 1.89±0.23* |
Table 4 is on the thrombotic impact of rats in vitro
| Group | Number of animals | Wet weight of thrombus (mg) |
| Matched group | 30 | 48.35±19.36 |
| Take group | 30 | 26.39±8.41* |
Table 5 is on the impact of rat oxygen deficit tolerance
| Group | Number of animals | Hypoxia endurance time (min) |
| Matched group | 30 | 31.3±4.3 |
| Take group | 30 | 61.1±12.1* |
Can reach a conclusion from above, this preparation has myocardial ischemia anoxia tolerance function.
Claims (10)
1. there is a biological preparation for control myocardial ischemia anoxia tolerance function, it is characterized in that, the component mainly comprising following weight percentage of this biological preparation:
2. the biological preparation with control myocardial ischemia anoxia tolerance function according to claim 1, is characterized in that, comprise the component of following weight percentage:
3. have a preparation method for the biological preparation of control myocardial ischemia anoxia tolerance function as claimed in claim 1, it is characterized in that, the method comprises the following steps:
(1) percentage composition takes raw material Flos Inulae 15-20% by weight; Radix Paeoniae Alba 10-20%; Fructus Crataegi 10-20%; Radix Puerariae 10-20%; Radix Ophiopogonis 10-20%; Radix Notoginseng 10-20%; Radix Rhodiolae 5-15%; Fructus Citri grandis 5-10%; Green tea 5-10%, adds the 8-12 alcoholic solution doubly of raw material weight, is uniformly mixed, reflux, extract, by extracting solution vacuum concentration, obtains concentrated solution A;
(2) by the Chinese medicine residue after alcohol reflux, add 6-10 weight portion deionization, reflux, extract, gained Aqueous extracts vacuum concentration, obtains concentrated solution B;
(3) by concentrated solution A, concentrated solution B mixes, and carries out vacuum drying, obtains this biological preparation.
4. the preparation method with the biological preparation of control myocardial ischemia anoxia tolerance function according to claim 3, it is characterized in that, the temperature of the reflux, extract, described in step (1) is 30-60 DEG C, and number of times is 2-3 time.
5. the preparation method with the biological preparation of control myocardial ischemia anoxia tolerance function according to claim 3, it is characterized in that, the temperature of the vacuum concentration described in step (1) is 50-80 DEG C, and vacuum is 500-700Pa.
6. the preparation method with the biological preparation of control myocardial ischemia anoxia tolerance function according to claim 3, it is characterized in that, the mass concentration of the alcoholic solution described in step (1) is 50-80%.
7. the preparation method with the biological preparation of control myocardial ischemia anoxia tolerance function according to claim 3, it is characterized in that, the density of described concentrated solution A is 1.03-1.06g/cm
3.
8. the preparation method with the biological preparation of control myocardial ischemia anoxia tolerance function according to claim 3, it is characterized in that, the temperature of the reflux, extract, described in step (2) is 50-80 DEG C, and number of times is 2-3 time.
9. the preparation method with the biological preparation of control myocardial ischemia anoxia tolerance function according to claim 3, it is characterized in that, the temperature of the vacuum concentration described in step (2) is 50-80 DEG C, and vacuum is 500-700Pa.
10. the preparation method with the biological preparation of control myocardial ischemia anoxia tolerance function according to claim 3, it is characterized in that, the density of described concentrated solution A is 1.05-10.08g/cm
3.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1596939A (en) * | 2004-07-28 | 2005-03-23 | 鞍山制药有限公司 | Chinese patent drug for treating heart brain blood vessel disease and its preparation method |
| CN1679706A (en) * | 2005-01-28 | 2005-10-12 | 北京阜康仁生物制药科技有限公司 | Medicinal preparation containing notoginseng and rhodiola root for cardio-cerebral blood vessel diseases and its preparing method |
| US20100119629A1 (en) * | 2005-11-10 | 2010-05-13 | Jose Angel Olalde Rangel | Angina pectoris and ischemic heart disease and synergistic phytoceutical composition for same |
| CN102125607A (en) * | 2010-01-20 | 2011-07-20 | 中国中医科学院中药研究所 | Medicinal composition and preparation method thereof |
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2015
- 2015-09-07 CN CN201510562995.5A patent/CN105079436A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1596939A (en) * | 2004-07-28 | 2005-03-23 | 鞍山制药有限公司 | Chinese patent drug for treating heart brain blood vessel disease and its preparation method |
| CN1679706A (en) * | 2005-01-28 | 2005-10-12 | 北京阜康仁生物制药科技有限公司 | Medicinal preparation containing notoginseng and rhodiola root for cardio-cerebral blood vessel diseases and its preparing method |
| US20100119629A1 (en) * | 2005-11-10 | 2010-05-13 | Jose Angel Olalde Rangel | Angina pectoris and ischemic heart disease and synergistic phytoceutical composition for same |
| CN102125607A (en) * | 2010-01-20 | 2011-07-20 | 中国中医科学院中药研究所 | Medicinal composition and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 余元勋等: "《中国分子医学系列丛书 中国分子心脏病学》", 31 August 2015, 安徽科学技术出版社 * |
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Application publication date: 20151125 |