CN1050761C - Oral administration liquid for curing acne and its preparing method - Google Patents

Abstract

The present invention relates to an oral liquid for treating acne, which is a medicament prepared from the following raw materials: herba schizonepetae, ledebouriella roots, balloonflower roots, immature orange fruits, gardenia, Chinese angelica roots, chuanxiong rhizome, coptis, scutellaria roots, forsythia fruits, licorice roots, dahurian angelica and peppermint. The raw materials are steamed, filtered, extracted with ethanol, fine filtered, sterilized by high temperature, and prepared into the oral liquid for treating acne. The present invention also has the efficacy of improving the microcirculation of a human body, whitening and smoothening skin, etc.

Description

A kind of oral liquid for the treatment of acne and preparation method thereof

The present invention relates to a kind of oral liquid for the treatment of acne and preparation method thereof, this medicine is raw material with Chinese medicine, through processed, is prepared into a kind of good effect, can makes the Chinese patent medicine of skin whitening, exquisiteness, taking convenience.

Acne claims acne again, is the youth of both sexes commonly encountered diseases, in face, and the sufferings sense is arranged because of how long, can leave over pigmentation and atrophic cicatrix, influences appearance, by adolescence is disliked.

One, the diagnosis and the cause of disease: be mainly in youth of both sexes, in the majority in facial lower jaw, also send out in breast, back sometimes.Faint yellow conical pimple can have milky fat bolt to discharge during extruding, acne claims " pimples " again.

" Waike Zhengzong, Orthodox Manual of External Diseases " said: " acne belong to Fei ， Zha nose and belong to spleen, and always all heat in blood stasis is not loose, what is called have all in, shape is all outer ".

Golden Mirror of Medicine clearly: " this card is by giving birth to through heat in blood, and every is played broken pimple in the face nose, and shape such as broomcorn millet are considered to be worth doing, and red complexion swells and ache, and breaks out white lead juice ".Adolescence can alleviate or disappear later.For common adolescence disease of sebaceous glands, because of eating and drinking without temperance, the greasy pungent thing of surfeit causes accumulateing in the damp-heat in the spleen and stomach and steams or the lung meridian intrinsic heat, is subjected to ailment said due to cold or exposure outward, or the cold water stain washes heat in blood is pented up, and fighting to tie in face forms.

The object of the present invention is to provide a kind of oral liquid for the treatment of acne, it is based on dispelling the damp pathogen with drugs of bitter in taste and cold in nature, heat-clearing and toxic substances removing, and lung qi dispersing expels the heat-evil, and blood circulation promoting and blood stasis dispelling, the method prescription patent medicine of dispersing swelling and dissipating binds solve the treatment acne, increase the problem of skin exquisiteness.

The object of the present invention is achieved like this: a kind of oral liquid for the treatment of acne is characterized in that it is the medicament of being made by following 13 flavor raw materials:

Herba Schizonepetae 1.5-3; Radix Saposhnikoviae 1.0-2.5; Radix Platycodonis 1.0-2.5;

Fructus Aurantii Immaturus 1.0-2.5; Fructus Gardeniae 1.0-2.5; Radix Angelicae Sinensis 1.0-2.5;

Rhizoma Chuanxiong 0.9-2.0; Rhizoma Coptidis 0.9-2.0; Radix Scutellariae 0.9-2.0;

Fructus Forsythiae 0.9-2.0; Radix Glycyrrhizae 0.9-2.0; Radix Angelicae Dahuricae 0.9-2.0;

Herba Menthae 0.9-3.0; (consumption is a weight ratio in the side, and unit is gram).

The prescription optimum amount proportioning of 13 above-mentioned flavor raw materials is:

Herba Schizonepetae 2.0g; Radix Saposhnikoviae 1.8g; Radix Platycodonis 1.8g;

Fructus Aurantii Immaturus 1.8g; Fructus Gardeniae 1.8g; Radix Angelicae Sinensis 1.8g;

Rhizoma Chuanxiong 1.2g; Rhizoma Coptidis 1.2g; Radix Scutellariae 1.2g;

Fructus Forsythiae 1.2g; Radix Glycyrrhizae 1.2g; Radix Angelicae Dahuricae 0.9g;

Herba Menthae 0.6g.

The preparation method that realizes the oral liquid of above-mentioned treatment acne is:

13 flavor raw material coarse powder such as above-mentioned Herba Schizonepetae are broken into crude drug mixing one place, add the decoction of octuple water gaging and got medicinal residues, group's medicine coarse filtration liquid, volatile oil in 1.5 hours, standby, afterwards;

1. the slag of getting it filled add seven times of water decoct again 1.5 hours medicinal residues coarse filtration liquid;

2. get group medicine coarse filtration liquid, it is the mixed liquor of 1.08-1.10 to relative density that medicinal residues coarse filtration liquid is combined into place's cooling concentration;

3. getting concentration and be 95% ethanol goes into to make in the mixed liquor it to contain the alcohol amount to reach 65%, stir afterwards and left standstill 48 hours;

4. reclaim ethanol, be concentrated into relative density 1.10 ± must not have alcohol flavor mixed liquor;

5. in mixed liquor, add volatile oil and the nearly full dose of distilled water;

6. 2-4 ℃ of cold preservation in following 24 hours of mixed liquor what temperature;

7. coarse filtration mixed liquor;

8. in mixed liquor, add sweeting agent and suspending agent;

9. fine straining mixed liquor and add distilled water to full dose;

10. divide the bottle and under 105 ℃ of high temperature, sterilizing of packing into;

reorganizes and outfit/produces.

Because the 13 flavor Chinese medicines that the present invention relates to are respectively:

Herba Schizonepetae---belong to Labiatae, slightly warm in nature, acrid in the mouth, but relieving the exterior syndrome by diaphoresis;

Radix Saposhnikoviae---belong to Umbelliferae, slightly warm in nature, acrid-sweet flavor, can dispel the wind, deliver,

Win wet;

Radix Platycodonis---belong to campanulaceae, property is flat, and the bitter in the mouth suffering can be eliminated the phlegm, lung qi dispersing, row

Pus;

Fructus Aurantii Immaturus---belong to Rutaceae, cold nature, bitter in the mouth acid, but dispelling the stagnated QI removing food stagnancy;

Fructus Gardeniae---genus rubia section, cold in nature, bitter in the mouth, but clearing away heat-fire;

Radix Angelicae Sinensis---belong to Umbelliferae, warm in nature, the sweet in the mouth toil can be enriched blood and be invigorated blood circulation;

Rhizoma Chuanxiong also claims rhizome of chuanxiong Rong---belong to shape section, warm in nature, acrid in the mouth can invigorate blood circulation, transfer

Through, dispel the wind, pain relieving;

Rhizoma Coptidis---belong to Ranunculaceae, cold in nature, bitter in the mouth, but eliminating fire and detoxication, heat clearing away are dry

Wet;

Radix Scutellariae---belong to Labiatae, cold in nature, bitter in the mouth, but purte the white, clearing away damp-heat;

Fructus Forsythiae---belong to Oleaceae, cold nature, bitter in the mouth, but heat-clearing and toxic substances removing, clear swollen

Eliminating stagnation;

Radix Glycyrrhizae claims Herba Hedyotis cantonensis again---belong to pulse family, property is flat, and sweet in the mouth, but easing middle-JIAO and tonifying for deficiency,

Eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription;

The Radix Angelicae Dahuricae---belong to Umbelliferae, warm in nature, acrid in the mouth can dispel the wind, cold expelling, dampness;

Herba Menthae---belong to Labiatae, cool in nature, acrid in the mouth can induce sweat, the wind heat of loosing;

Therefore, it is obvious that the oral liquid that is prepared from according to above-mentioned Chinese prescription has antiinflammatory action, can suppress capillary permeability again and make that inflammation alleviates, antiinflammatory, make that immune function of human body improves, microcirculqtory system improves, and reaches the effect of aspects such as making human body skin brightens, exquisiteness.

Below in conjunction with embodiment the present invention is described in further detail:

Take off and state the prescription that 13 flavor proportioning raw materials become the treatment oral liquid for acne:

Herba Schizonepetae 1.5-3; Radix Saposhnikoviae 1.0-2.5; Radix Platycodonis 1.0-2.5;

Fructus Aurantii Immaturus 2.0-2.5; Cape jasmine is in 1.0-2.5; Radix Angelicae Sinensis 1.0-2.5;

Rhizoma Chuanxiong 0.9-2.0; Rhizoma Coptidis 0.9-2.0; Radix Scutellariae 0.9-2.0;

Fructus Forsythiae 0.g-2.0; Radix Glycyrrhizae 0.9-2.0; Radix Angelicae Dahuricae 0.9-2.0;

Herba Menthae 0.9-3.0; (consumption is a weight ratio in the side, and unit is gram).

The prescription optimum amount proportioning of 13 above-mentioned flavor raw materials is;

Herba Schizonepetae 2.0g; Radix Saposhnikoviae 1.8g; Radix Platycodonis 1.8g;

Fructus Aurantii Immaturus 1.8g; Fructus Gardeniae 1.8g; Radix Angelicae Sinensis 1.8g;

Rhizoma Chuanxiong 1.2g; Rhizoma Coptidis 1.2g; Radix Scutellariae 1.2g;

Fructus Forsythiae 1.2g; Radix Glycyrrhizae 1.2g; Radix Angelicae Dahuricae 0.9g;

Herba Menthae 0.6g.

The method of the treatment oral liquid for acne that is prepared into by above-mentioned Chinese medicine preparation then is: above-mentioned raw material coarse powder such as Herba Schizonepetae are broken into crude drug mixing one place, add the octuple water gaging decocted 1.5 hours medicinal residues, group's medicine coarse filtration liquid, volatile oil, standby, afterwards:

1. the slag of getting it filled add seven times of water decoct again 1.5 hours medicinal residues coarse filtration liquid;

2. get group medicine coarse filtration liquid, it is the mixed liquor of 1.08-1.10 to relative density that medicinal residues coarse filtration liquid is combined into place's cooling concentration;

3. getting concentration and be 95% ethanol goes into to make in the mixed liquor it to contain the alcohol amount to reach 65%, stir afterwards and left standstill 48 hours;

4. reclaim ethanol, be concentrated into relative density 1.10 ± must not have alcohol flavor mixed liquor;

5. in mixed liquor, add volatile oil and the nearly full dose of distilled water;

6. 2-4 ℃ of cold preservation in following 24 hours of mixed liquor what temperature;

7. coarse filtration mixed liquor;

8. in mixed liquor, add sweeting agent and suspending agent;

9. fine straining mixed liquor and add distilled water to full dose;

10. divide the bottle and under 105 ℃ of high temperature, sterilizing of packing into;

reorganizes and outfit/produces.

The oral liquid made from above-mentioned drug matching is through the result of clinical observation:

Case 37 examples, male 10 examples, woman's 27 examples:

Age group: 13-40 year

13-20 year	20-30 year	31-40 year
			11 people	20 people	6 people

Chinese medical discrimination: belong to damp-heat in the spleen and stomach, lung meridian intrinsic heat, be subjected to ailment said due to cold or exposure outward.

Main symptom: stomach discomfort is arranged more, fidgety irritability, pain in the lumbar region, fatigue and weak is hard and dry, and brothers heating makes before the acne menstruation and increases the weight of, and it is many to itch in the part, pain very then, facial pore expansion.

The inspection pulse-taking: simple and unadorned, the facial many pimples that neck two adnations have in various degree, quantity does not wait under forehead and two cheek sides or jaw of dim complexion, abscess, acne or while are left over cicatrix with acne, and skin of face is coarse, and pore increases (expansion).

White, the thick greasy or little Huang of tongue fur, tongue fur is dark or dark.

Deep-rolling pulse or heavy string.

Observational technique: according to the facial acne degree

Select case: 15 days is a course of treatment

The lighter: every day is (medicine) being taken before meal sooner or later, obeys one at every turn.

Weight person: every day is (medicine) being taken before meal sooner or later, obeys two at every turn.

Efficacy assessment standard:

1, treatment: acne and whole body symptom all disappear, and the face skin brightens exquisiteness.

2, produce effects: acne and whole body symptom major part (more than 70%) disappear, and face brightens exquisiteness.

3, effective; The acne and the whole body are demonstrate,proved shape and are partly disappeared or the recidivist is arranged.Face brightens exquisiteness.

4, invalid: as not have change.

Efficacy analysis;

Curative effect number percentage ratio

Treat 1 19 people 51.35%

Produce effects 15 people 40.54%

Effective 2 people 5.41%

Invalid people's 2.70% brief summary: 1, treatment and obvious effective rate are 91.89%, onset in three days after the medication.2, age group occurred frequently: 13-30 year.3, medication makes skin of face brighten exquisiteness, shrinking pore.

4, there is part patient medication that acne is temporarily increased, continues medication and all disappear thereupon.

5, flu is not treated, and daily life impermanence, uv damage all influence clinical effectiveness.

6, period in a medicine is careful in one's diet, and avoids delicious food savoury and maror, and giving up alcohol subtracts cigarette.

The sweeting agent that adds in its preparation process of the oral liquid that the present invention relates to, suspending agent can be chrysanthemum leaf sugar or sugar or Mel, and albumen colloid liquid etc.

Preparation technology's flow process of this product is in accompanying drawing one expression.

Claims (3)

1, a kind of oral liquid for the treatment of acne is characterized in that it is the medicament of being made by following 13 flavor raw materials:

Herba Schizonepetae 1.5-3g Radix Saposhnikoviae 1.0-2.5g Radix Platycodonis 1.0-2.5g

Fructus Aurantii Immaturus 1.0-2.5g Fructus Gardeniae 1.0-2.5g Radix Angelicae Sinensis 1.0-2.5g

Rhizoma Chuanxiong 0.9-2.0g Rhizoma Coptidis 0.9-2.0g Radix Scutellariae 0.9-2.0g

Fructus Forsythiae 0.9-2.0g Radix Glycyrrhizae 0.9-2.0g Radix Angelicae Dahuricae 0.9-2.0g

Herba Menthae 0.9-3.0g

2, a kind of oral liquid for the treatment of acne according to claim 1 is characterized in that the prescription consumption proportion of 13 above-mentioned flavor raw materials is:

Herba Schizonepetae 2.0g Radix Saposhnikoviae 1.8g Radix Platycodonis 1.8g

Fructus Aurantii Immaturus 1.8g Fructus Gardeniae 1.8g Radix Angelicae Sinensis 1.8g

Rhizoma Chuanxiong 1.2g Rhizoma Coptidis 1.2g Radix Scutellariae 1.2g

Fructus Forsythiae 1.2g Radix Glycyrrhizae 1.2g Radix Angelicae Dahuricae 0.9g

Herba Menthae 0.6g

3, a kind of preparation method for the treatment of the oral liquid of acne according to claim 1 and 2, it is characterized in that 13 flavor raw material coarse powder such as above-mentioned Herba Schizonepetae are broken into crude drug mixing one place, add the decoction of octuple water gaging and got medicinal residues, group's medicine coarse filtration liquid, volatile oil in 1.5 hours, standby, afterwards:

1. the slag of getting it filled add seven times of water decoct again 1.5 hours medicinal residues coarse filtration liquid;

2. getting group medicine coarse filtration liquid, medicinal residues coarse filtration liquid, to be combined into place's cooling concentration be the mixed liquor of 1.08-1.10 to relative density;

3. getting concentration and be 95% ethanol goes into to make in the mixed liquor it to contain the alcohol amount to reach 65%, stir afterwards and left standstill 48 hours;

4. reclaim ethanol, be concentrated into relative density 1.10 ± must not have alcohol flavor mixed liquor;

5. in mixed liquor, add volatile oil and the nearly full dose of distilled water;

6. 2-4 ℃ of cold preservation in following 24 hours of mixed liquor what temperature;

7. coarse filtration mixed liquor;

8. in mixed liquor, add sweeting agent and suspending agent;

9. fine straining mixed liquor and add distilled water to full dose;

10. divide the bottle and under 105 ℃ of high temperature, sterilizing of packing into;

reorganizes and outfit, and produces.

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