CN105076128A - Microcapsule suspension containing fosthiazate and metalaxyl-M - Google Patents
Microcapsule suspension containing fosthiazate and metalaxyl-M Download PDFInfo
- Publication number
- CN105076128A CN105076128A CN201510540990.2A CN201510540990A CN105076128A CN 105076128 A CN105076128 A CN 105076128A CN 201510540990 A CN201510540990 A CN 201510540990A CN 105076128 A CN105076128 A CN 105076128A
- Authority
- CN
- China
- Prior art keywords
- metalaxyl
- fosthiazate
- suspending agent
- microcapsule suspending
- percent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a microcapsule suspension containing fosthiazate and metalaxyl-M. The microcapsule suspension is prepared through complex coacervation, and consists of the following components by weight percentage: 1 percent to 30 percent of fosthiazate, 1 percent to 20 percent of metalaxyl-M, 3 percent to 15 percent of solvent, 5 percent to 10 percent of capsule wall material, 0.5 percent to 5 percent of curing agent, 3 percent to 10 percent of emulsifier, 1 percent to 5 percent of dispersing agent and balance of water made up to 100 percent. The microcapsule suspension containing fosthiazate and metalaxyl-M, disclosed by the invention, is high in stability, long in lasting period, safe to use and low in environmental pollution, and can be used for pollution-free production in agricultural field.
Description
Technical field
The invention belongs to field of pesticide preparation, be specifically related to a kind of microcapsule suspending agent containing fosthiazate and Metalaxyl-M.
Background technology
Nematode is the widest, the heaviest to the murrain insect that distributes in the world at present, is also that whole world plant protection circle is concerned about most, the most masty difficult problem.The loss whole world caused due to eelworm harm is annual all tens hundred million to hundreds of hundred million dollars, and the loss causing the economic crops such as vegetables, soybean, peanut at home because of eelworm harm is also very surprising.
In recent years, due to single drug and other unscientific application methods, caused a lot of agricultural chemicals of many diseases to current use to create resistance, become a great problem of chemical control.Because resistance strengthens, the frequent dispenser of peasant, dosage increase corresponding to times for spraying, thus cause peasant burden to increase the weight of and increasing environmental pollution.The disease chemical control that Oomycete causes shows particularly outstanding, Oomycete, except causing leaf diseases such as white epidemic disease mould grade, can also cause various soil-borne disease.
Fosthiazate is organic phosphates nematocide, main effect model is the synthesis suppressing root-knot nematode acetylcholinesterase, can be used for preventing and treating all kinds of root-knot nematode, have and tag and systemic action, kill root-knot nematode mainly through two kinds of modes: nematode contact soil in fosthiazate and dead; Be drawn to crop root in fosthiazate and kill the root-knot nematode invading crop root formation root nodule; Fosthiazate has upwards transport properties, conducts strong by crop root to blade, weak to flower conduction by blade, substantially can't help to spend and conducts to fruit; Blade control sucking pest can be conducted to as aphid etc.
Metalaxyl-M, english common name Metalaxyl-M is the R isomer of common metalaxyl; be a kind of efficient systemic fungicide, have protection and therapeutic action, drug effect is high, residual low; there is good Environmental compatibility, be a kind of systematic, there is the bactericide of prevention and therapy effect.Metalaxyl-M in late blight morning of control melon and fruit, the white viral disease of vegetables, epidemic disease, potato, black shank than racemic metalaxyl drug effect height 2-10 doubly, greatly reduce dose; In degraded in soil fast 2 times, therefore and more environmental protection more more efficient than metalaxyl.These two kinds of bactericide are 3.50 hundred million dollars at global marketing volume in 2011.
In Metalaxyl-M, absorption is good, can be absorbed by the root, stem and leaf of plant, and with In Water Transportation In Plants, and transfer to each organ of plant, have Bidirectional Conduction performance, lasting period 10 ~ 14d, the soil treatment lasting period can more than 2 months, to the microbial various crop downy mildew of Pseudoperonospora cubensis, phytophthora root rot bacterium and maize ear rot, phytophthora root rot, the millet downy mildew of gourd, fruit and vegetable class are effective.Can be used for preventing and treating apple, fire blight of pear, wildfire, blue mildew, soft rot of cabbage, tomato bacterial mottled rot is sick, late blight, seed potato rot, balck shank, angular leaf spot of cucumber, downy mildew, Kidney bean downy mildew, bacterial epidemic disease, celery bacterial epidemic disease, sesame bacterial leaf spot etc.
A lot of crop when soil-borne disease occurs along with the generation of nematodiasis, if separately control, both the amount of labour was increased, add heavily contaminated again, in the modern countryside that labour lacks very much, be the unscientific behavior of poor efficiency, if by composite with the Metalaxyl-M preventing and treating soil-borne disease for the fosthiazate preventing and treating nematodosis, well solve this problem, have good economic results in society.
Current agricultural chemicals availability is not high, and major part loss in the environment, does not play the effect of kill harmful biology, and wherein having is because the factor such as light, water, microorganism in environment result in its decomposition failure greatly.Active ingredient is wrapped up by very thin one deck capsule skin by microcapsule formulations; after reaching release conditions in nature slow releasing; play the object of control pest damage; and the composition do not discharged is subject to the protection of capsule skin; decompose hardly; therefore play increase efficiency time, reduce the effect of environmental pollution.Be conducive to the sustainable development of agricultural.
The preparation method of micro-capsule is a lot, can be divided into physical-chemical process, chemical method and physicomechanical processes.Suitable preparation method can be selected by the size etc. of the character of capsule core material, capsule material, equipment and micro-capsule.Mainly contain single (answering) coacervation, situ aggregation method, interfacial polymerization etc.Wherein complex coacervation due to embedding efficiency high, mild condition, has unique advantage.It is the tiny capsules utilizing natural, semi-synthetic macromolecule material capsule material solid or liquid medicine to be wrapped up.Its principle utilizes two kinds or two or more high molecular polymers to be wall material, under suitable condition, make the polymer generation electrostatic adsorption of oppositely charged, thus a kind of microencapsulation method of embedding core, make and be divided into the several step of emulsification, cohesion, encystation and solidification according to process.
Summary of the invention
The invention provides a kind of microcapsule suspending agent containing fosthiazate and Metalaxyl-M and preparation method thereof.
Of the present inventionly to be achieved through the following technical solutions:
A kind of microcapsule suspending agent containing fosthiazate and Metalaxyl-M, be made up of the component of following percentage by weight: fosthiazate 1%-30%, Metalaxyl-M 1%-20%, solvent 3%-15%, cyst material 5%-10%, curing agent 0.5%-5%, emulsifier 3%-10%, dispersant 1%-5%, water supplies 100%
Described capsule-core solvent is the mixing of one or more in cyclohexanone, ethyl acetate, 1-METHYLPYRROLIDONE, diethyl phthalate, dibutyl phthalate, Solvesso100, Solvesso150, Solvesso200.
Described emulsifier is one or more the mixing in alkylphenol polyoxyethylene, styryl phenol polyethenoxy ether, alkaryl phenol polyethenoxy ether phosphate, castor oil polyoxyethylene ether, alkylbenzenesulfonate, alkylphenol-polyethenoxy phosphate, disecoctylmaleate sodium sulfonate, polyol fatty acid ester and ethylene oxide adduct thereof.
Described dispersant is the mixing of one or more in alkylphenol polyoxyethylene formaldehyde condensation products sulphate, sodium methylene bis-naphthalene sulfonate, alkylaryl polyoxyethylene polyoxypropylene ether, sodium lignin sulfonate, calcium lignosulfonate, polycarboxylic acid salt's dispersant.
Described water is deionized water.
Described cyst material is gelatin and the mixing of high molecular cellulose (CMC or HPMC).
Described curing agent is the one in formaldehyde or glutaraldehyde.
Described thickener is one or both the mixing in xanthans, Magnesiumaluminumsilicate, polyvinyl alcohol.
The encapsulation process of described microcapsule suspending agent is complex coacervation.
Fosthiazate of the present invention and Metalaxyl-M microcapsule suspending agent can adopt following methods to prepare:
(1) preparation of emulsion:
Get CMC or HPMC, fully dissolve by appropriate amount of deionized water rear for subsequent use;
After dissolution with solvents fosthiazate and Metalaxyl-M, add emulsifier, for subsequent use after mixing and stirring in agitator;
By measure deionized water suction homogenizer in, add the solution of CMC or the HPMC solution of dissolving, fosthiazate and Metalaxyl-M, limit edged stirs, and with the speed emulsifying 20-100min of 2000-10000r/min after adding, obtains stable O/w emulsion A;
(2) multiple cohesion: take gelatin, add deionized water dissolving, be warming up to 50 DEG C, after gelatin dissolves completely, obtain the aqueous solution, mix with step (1) emulsion, at 40-50 DEG C of temperature, by 10% acetic acid adjust ph to 4-4.5, isothermal reaction 40-60min, forming reactions thing;
(3) solidify: the reactant that step (2) obtains is cooled to temperature 0-5 DEG C, is 8-10 by 20% sodium hydroxide solution adjust ph, adds curing agent, curing reaction 40-60min; Slowly be warming up to 30-50 DEG C, add the water of surplus in viscosity modifier, dispersant and formula, obtain the microcapsule suspending agent of fosthiazate and Metalaxyl-M.
The invention provides a kind of lasting period length, low toxicity, environmentally friendly, person poultry safety, the fosthiazate not easily develop immunity to drugs to insect and Metalaxyl-M microcapsule suspending agent, stable performance, easily degrades, and grows tall to the crop pests lasting period, and environmental pollution is very little.Compared with prior art, provide the more eco-friendly pesticidal preparations of one, meet agriculture non-environmental pollution control needs.
Embodiment
Essence for a better understanding of the present invention, with example, technology contents of the present invention is described below, but content of the present invention is not limited thereto.
Embodiment one: 20% fosthiazate Metalaxyl-M microcapsule suspending agent.
1, preparation method:
1. get 2 grams of CMC, fully dissolve rear for subsequent use by 30 grams of deionized waters;
2., after dissolving 18 grams of fosthiazates and 2 grams of Metalaxyl-Ms with 10 grams of Solvesso150, alkaryl phenol polyethenoxy ether phosphate 1.5 grams, disecoctylmaleate sodium sulfonate 1 gram of emulsifier is added, for subsequent use after mixing and stirring in agitator;
3. 1. step is played liquid high shear machine and carried out emulsifying with the speed of 7000r/min, slowly add 2. step simultaneously and play liquid, with the speed emulsifying 10min of 7000r/min after adding, obtain stable O/w emulsion A;
4. take 1g gelatin, add 30 grams of deionized water dissolvings, be warming up to 50 DEG C, after gelatin dissolves completely, obtain aqueous solution B, B and A mixes, and at 40 DEG C of temperature, regulates the pH value to 4 of B and A mixture, isothermal reaction 60min, forming reactions thing C with 10% acetic acid;
5. reactant C being cooled to temperature 5 DEG C, is 8 by 20% sodium hydroxide solution adjust ph, adds 1 gram of glutaraldehyde, curing reaction 60min; Slowly be warming up to 40-50 DEG C, add 0.1 gram of xanthans (can first pretreatment) and 2 grams of polycarboxylate salt dispersants, be stirred to the microcapsule suspending agent namely obtaining fosthiazate and Metalaxyl-M completely evenly.
Detect: outward appearance: be lark suspension.Particle diameter: detecting D50 with Dandong Bai Te laser fineness gage is 2.1 microns.Clad ratio: seldom, clad ratio is 99.5% for fosthiazate free after testing and Metalaxyl-M.
Field is raw surveys experiment, prevents and treats nematodosis and soil-borne disease, within 2 months, still has 70% preventive effect, far above 30% of regular dosage form.
Embodiment two: 10% fosthiazate Metalaxyl-M microcapsule suspending agent.
1. get 1 gram of CMC, fully dissolve rear for subsequent use by 15 grams of deionized waters;
2., after dissolving 9 grams of fosthiazates and 1 gram of Metalaxyl-M with 5 grams of Solvesso150, alkaryl phenol polyethenoxy ether phosphate 1 gram, disecoctylmaleate sodium sulfonate 0.75 gram of emulsifier is added, for subsequent use after mixing and stirring in agitator;
3. 1. step is played liquid high shear machine and carried out emulsifying with the speed of 8000r/min, slowly add 2. step simultaneously and play liquid, with the speed emulsifying 20min of 8000r/min after adding, obtain stable O/w emulsion A;
4. take 0.5g gelatin, add 20 grams of deionized water dissolvings, be warming up to 50 DEG C, after gelatin dissolves completely, obtain aqueous solution B, B and A mixes, at 45 DEG C of temperature, the pH value to 4.54 of B and A mixture is regulated, isothermal reaction 50min, forming reactions thing C with 10% acetic acid;
5. reactant C being cooled to temperature 5 DEG C, is 9 by 20% sodium hydroxide solution adjust ph, adds 0.5 gram of glutaraldehyde, curing reaction 60min; Slowly be warming up to 40-50 DEG C, add 0.15 gram of xanthans (can first pretreatment) and 2 grams of polycarboxylate salt dispersants, be stirred to the microcapsule suspending agent namely obtaining fosthiazate and Metalaxyl-M completely evenly.
Detect: outward appearance: be lark suspension.Particle diameter: detecting D50 with Dandong Bai Te laser fineness gage is 2.5 microns.Clad ratio: seldom, clad ratio is 99.9% for fosthiazate free after testing and Metalaxyl-M.
Field is raw surveys experiment, prevents and treats nematodosis and soil-borne disease, within 3 months, still has 70% preventive effect, far above 30% of regular dosage form.
Embodiment three: field control effectiveness test.
Adopt 20% fosthiazate Metalaxyl-M microcapsule suspending agent of the present invention for field control cucumber root-knot nematode, capsicum damping off.Field control effectiveness test shows, 20% fosthiazate Metalaxyl-M microcapsule suspending agent uses 500 grams/acre to prevent and treat cucumber root-knot nematode, after medicine, 15 days preventive effects reach 85.5%, with contrast medicament 20% Fosthiazate aqueous emulsion and 19% fosthiazate microcapsule suspending agent difference is not remarkable, within after medicine 90 days, still effectively can control the harm of cucumber root-knot nematode, preventive effect reaches 70%, is far superior to contrast medicament 20% Fosthiazate aqueous emulsion, but little with the difference of 19% fosthiazate microcapsule suspending agent.To capsicum damping off 20% fosthiazate Metalaxyl-M microcapsule suspending agent and 2% Metalaxyl-M microcapsule suspending agent be no matter 15 days or 90 days difference little, but with 2% Metalaxyl-M aqueous emulsion difference clearly.As can be seen from above, 20% fosthiazate Metalaxyl-M microcapsule suspending agent, compared with regular dosage form, extends the lasting period.And both are composite, expand control spectrum.
Microcapsule suspending agent of the present invention not only increases stability compared with the formulations such as existing aqueous emulsion, also extends the lasting period, decreases application times and amount of application, also reduces its harmful effect to environment and agricultural product, thus improves the safety of medication.
Table 1, field control effectiveness test result
Claims (9)
1. one kind contains the microcapsule suspending agent of fosthiazate and Metalaxyl-M, it is characterized in that, be made up of the component of following percentage by weight: fosthiazate 1%-30%, Metalaxyl-M 1%-20%, solvent 3%-15%, cyst material 5%-10%, curing agent 0.5%-5%, emulsifier 3%-10%, dispersant 1%-5%, water supplies 100%.
2. a kind of microcapsule suspending agent containing fosthiazate and Metalaxyl-M according to claim 1, is characterized in that: described capsule-core solvent is the mixing of one or more in cyclohexanone, ethyl acetate, 1-METHYLPYRROLIDONE, diethyl phthalate, dibutyl phthalate, Solvesso100, Solvesso150, Solvesso200.
3. a kind of microcapsule suspending agent containing fosthiazate and Metalaxyl-M according to claim 1, is characterized in that: described emulsifier is one or more the mixing in alkylphenol polyoxyethylene, styryl phenol polyethenoxy ether, alkaryl phenol polyethenoxy ether phosphate, castor oil polyoxyethylene ether, alkylbenzenesulfonate, alkylphenol-polyethenoxy phosphate, disecoctylmaleate sodium sulfonate, polyol fatty acid ester and ethylene oxide adduct thereof.
4. a kind of microcapsule suspending agent containing fosthiazate and Metalaxyl-M according to claim 1, is characterized in that: described dispersant is the mixing of one or more in alkylphenol polyoxyethylene formaldehyde condensation products sulphate, sodium methylene bis-naphthalene sulfonate, alkylaryl polyoxyethylene polyoxypropylene ether, sodium lignin sulfonate, calcium lignosulfonate, polycarboxylic acid salt's dispersant.
5. a kind of microcapsule suspending agent containing fosthiazate and Metalaxyl-M according to claim 1, is characterized in that: described water is deionized water.
6. a kind of microcapsule suspending agent containing fosthiazate and Metalaxyl-M according to claim 1, is characterized in that: described cyst material is gelatin and the mixing of high molecular cellulose.
7. a kind of microcapsule suspending agent containing fosthiazate and Metalaxyl-M according to claim 1, is characterized in that: described curing agent is the one in formaldehyde or glutaraldehyde.
8. a kind of microcapsule suspending agent containing fosthiazate and Metalaxyl-M according to claim 1, is characterized in that: described thickener is one or both the mixing in xanthans, Magnesiumaluminumsilicate, polyvinyl alcohol.
9. a kind of microcapsule suspending agent containing fosthiazate and Metalaxyl-M according to claim 1, is characterized in that: the encapsulation process of described microcapsule suspending agent is complex coacervation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510540990.2A CN105076128A (en) | 2015-08-27 | 2015-08-27 | Microcapsule suspension containing fosthiazate and metalaxyl-M |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510540990.2A CN105076128A (en) | 2015-08-27 | 2015-08-27 | Microcapsule suspension containing fosthiazate and metalaxyl-M |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105076128A true CN105076128A (en) | 2015-11-25 |
Family
ID=54558198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510540990.2A Pending CN105076128A (en) | 2015-08-27 | 2015-08-27 | Microcapsule suspension containing fosthiazate and metalaxyl-M |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105076128A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112155011A (en) * | 2020-09-17 | 2021-01-01 | 惠州市银农科技股份有限公司 | Emamectin benzoate microcapsule suspending agent and preparation method thereof |
-
2015
- 2015-08-27 CN CN201510540990.2A patent/CN105076128A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112155011A (en) * | 2020-09-17 | 2021-01-01 | 惠州市银农科技股份有限公司 | Emamectin benzoate microcapsule suspending agent and preparation method thereof |
| CN112155011B (en) * | 2020-09-17 | 2022-07-05 | 惠州市银农科技股份有限公司 | Emamectin benzoate microcapsule suspending agent and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102771506A (en) | Nematicide composition containing oligosaccharides and application thereof | |
| CN105237203A (en) | Long-acting biological medicine fertilizer for peanuts and preparation method of long-acting biological medicine fertilizer | |
| CN100493353C (en) | Sucrose ester insecticide and method for preparing the same | |
| CN103651550A (en) | Microcapsule suspending agent prepared from carbosulfan, chlorpyrifos and abamectin by compounding | |
| CN1094040C (en) | Nimbin mixed pesticide preparation and its preparing method | |
| CN102177887A (en) | Diafenthiuron emulsion in water and preparation method thereof | |
| CN103222463A (en) | Method for preparing 2-amino-5-thiol-1, 3, 4-thiadiazole copper controlled-release microcapsule and prepared microcapsule | |
| CN105076191A (en) | Efficient cyfluthrin microcapsule suspending agent and preparation method thereof | |
| CN105076128A (en) | Microcapsule suspension containing fosthiazate and metalaxyl-M | |
| CN105076144A (en) | Microcapsule suspending agent containing metalaxyl-M and azoxystrobin | |
| CN107950541A (en) | A kind of garlic seed coat agent composition and preparation method thereof | |
| CN102228056B (en) | Pesticide composition containing sulfur-fluorine oxime ether and part of organophosphorus pesticides | |
| CN103120179A (en) | Chlorpyrifos and triazophos-containing insecticidal composition and preparation method thereof | |
| CN101480187B (en) | Disinsection/miticide pharmaceutical composition | |
| CN105961383B (en) | A kind of longicorn lures the preparation method of contact insecticide | |
| CN105340915A (en) | Sterilization composition containing benziothiazolinone and Xinjunan acetate | |
| CN102805089B (en) | Insect and mite killing composition containing Cyflumetofen and emamectin benzoate | |
| CN105104422A (en) | Micro-capsule suspending agent containing fosthiazate and pyraclostrobin | |
| CN105076202A (en) | Microcapsule suspension containing fosthiazate and beta-cyfluthrin | |
| CN102027949A (en) | Brassinolide neem microcapsule | |
| CN101961009B (en) | Flubendiamide insecticidal microemulsion and preparation method thereof | |
| CN102217645B (en) | Insecticidal composition containing novaluron and organophosphorus compounds | |
| CN102228053B (en) | Pesticide composition containing novaluron and pyrethroid compound | |
| CN107821442A (en) | A kind of green muscardine fungus conidium microcapsule emulsion preparation method | |
| CN103651544A (en) | Acaricidal composition of profenofos and etoxazole and formula instance |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20151125 |