CN105073751B - 作为酪蛋白激酶1δ/ε抑制剂的新的取代的咪唑 - Google Patents

作为酪蛋白激酶1δ/ε抑制剂的新的取代的咪唑 Download PDF

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Publication number
CN105073751B
CN105073751B CN201380073382.4A CN201380073382A CN105073751B CN 105073751 B CN105073751 B CN 105073751B CN 201380073382 A CN201380073382 A CN 201380073382A CN 105073751 B CN105073751 B CN 105073751B
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CN201380073382.4A
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English (en)
Chinese (zh)
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CN105073751A (zh
Inventor
U.韦拉帕蒂
C.P.达恩
D.S.多德
A.J.桑波纳罗
M.D.维特曼
S.库马拉维尔
D.马利克
R.C.雷迪
P.刘
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201380073382.4A 2012-12-21 2013-12-20 作为酪蛋白激酶1δ/ε抑制剂的新的取代的咪唑 Expired - Fee Related CN105073751B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261740564P 2012-12-21 2012-12-21
US61/740564 2012-12-21
PCT/US2013/076795 WO2014100533A1 (en) 2012-12-21 2013-12-20 NOVEL SUBSTITUTED IMIDAZOLES AS CASEIN KINASE 1 δ/ε INHIBITORS

Publications (2)

Publication Number Publication Date
CN105073751A CN105073751A (zh) 2015-11-18
CN105073751B true CN105073751B (zh) 2018-11-30

Family

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Family Applications (1)

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CN201380073382.4A Expired - Fee Related CN105073751B (zh) 2012-12-21 2013-12-20 作为酪蛋白激酶1δ/ε抑制剂的新的取代的咪唑

Country Status (5)

Country Link
US (1) US9556179B2 (enExample)
EP (1) EP2935271B1 (enExample)
JP (1) JP6267231B2 (enExample)
CN (1) CN105073751B (enExample)
WO (1) WO2014100533A1 (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6283688B2 (ja) 2012-12-21 2018-02-21 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ カゼインキナーゼ１ｄ／ｅ阻害剤としての新規なピラゾール置換のイミダゾピラジン
EP3157925B1 (en) * 2014-06-19 2019-12-18 Bristol-Myers Squibb Company Imidazo-pyridazine derivatives as casein kinase 1 delta/epsilon inhibitors
CN107207531B (zh) * 2014-11-21 2021-05-25 里格尔药品股份有限公司 作为TGF-β抑制剂的稠合的咪唑衍生物
US9884868B2 (en) * 2015-03-02 2018-02-06 Rigel Pharmaceuticals, Inc. TGF-beta inhibitors
CN107847480B (zh) 2015-03-23 2021-06-25 墨尔本大学 呼吸性疾病的治疗
WO2017020981A1 (en) 2015-07-31 2017-02-09 Merck Patent Gmbh Bicyclic heterocyclic derivatives
KR102640385B1 (ko) * 2016-09-21 2024-02-23 벡투스 바이오시스템즈 리미티드 고혈압 및/또는 폐 섬유증 치료용 조성물
WO2018224455A1 (en) 2017-06-07 2018-12-13 Basf Se Substituted cyclopropyl derivatives
DK3774795T3 (da) * 2018-03-29 2022-06-27 Univ Masarykova 4-(1h-imidazol-5-yl)-1h-pyrrolo[2,3-b]-pyridiner til anvendelse ved behandling af leukæmier, lymfomer og solide tumorer
JP7646132B2 (ja) * 2018-09-09 2025-03-17 カナートファーマ アーゲー 血管疾患の治療におけるカゼインキナーゼ１阻害剤の使用
WO2020093098A1 (en) 2018-11-07 2020-05-14 The University Of Melbourne Novel compounds for the treatment of respiratory diseases
US11739078B2 (en) * 2019-02-22 2023-08-29 Insilico Medicine Ip Limited Methods of inhibiting kinases
US11530197B2 (en) 2021-02-24 2022-12-20 Insilico Medicine Ip Limited Analogs for the treatment of disease
WO2025231112A1 (en) * 2024-05-01 2025-11-06 Nimbus Salacia, Inc. Sik2 modulators and uses thereof
WO2025231117A1 (en) * 2024-05-01 2025-11-06 Nimbus Salacia, Inc. Sik2 modulators and uses thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1532118A2 (en) * 2002-07-05 2005-05-25 Axxima Pharmaceuticals Aktiengesellschaft Imidazole compounds for the treatment of hepatitis c virus infections
US20070078136A1 (en) * 2005-09-22 2007-04-05 Bristol-Myers Squibb Company Fused heterocyclic compounds useful as kinase modulators
JPWO2008016131A1 (ja) * 2006-08-04 2009-12-24 武田薬品工業株式会社 縮合複素環化合物
US8188083B2 (en) * 2007-06-28 2012-05-29 Abbott Laboratories Triazolopyridazines
FR2918986B1 (fr) 2007-07-19 2009-09-04 Sanofi Aventis Sa Derives de 6-cycloamino-3-(pyridazin-4-yl)imidazo[1,2-b]- pyridazine, leur preparation et leur application en therapeutique
WO2009085230A1 (en) 2007-12-19 2009-07-09 Amgen Inc. Inhibitors of pi3 kinase
US8703811B2 (en) 2008-05-07 2014-04-22 Genzyme Corporation Small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase
TWI501965B (zh) 2008-06-20 2015-10-01 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之新穎苯基咪唑衍生物
FR2940285A1 (fr) 2008-12-19 2010-06-25 Sanofi Aventis Derives de 6-cycloamino-2-thienyl-3-(pyridin-4-yl)imidazo °1,2-b!-pyridazine et 6-cycloamino-2-furanyl-3- (pyridin-4-yl)imidazo°1,2-b!-pyridazine, leur preparation et leur application en therapeutique
FR2940284B1 (fr) 2008-12-19 2011-02-18 Sanofi Aventis Derives de 6-cycloamino-2,3-di-pyridinyl-imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique
US20100204265A1 (en) 2009-02-09 2010-08-12 Genelabs Technologies, Inc. Certain Nitrogen Containing Bicyclic Chemical Entities for Treating Viral Infections
UA107791C2 (en) 2009-05-05 2015-02-25 Dow Agrosciences Llc Pesticidal compositions
RS53246B (sr) 2009-10-28 2014-08-29 Pfizer Inc. Derivati imidazola kao inhibitori kazein kinaze
JP6283688B2 (ja) 2012-12-21 2018-02-21 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ カゼインキナーゼ１ｄ／ｅ阻害剤としての新規なピラゾール置換のイミダゾピラジン

Also Published As

Publication number Publication date
JP6267231B2 (ja) 2018-01-24
WO2014100533A1 (en) 2014-06-26
EP2935271A1 (en) 2015-10-28
US20150344481A1 (en) 2015-12-03
US9556179B2 (en) 2017-01-31
JP2016507502A (ja) 2016-03-10
EP2935271B1 (en) 2017-10-25
CN105073751A (zh) 2015-11-18

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Granted publication date: 20181130

Termination date: 20211220