CN105068574A - Electronic control system of biochemical analyzer - Google Patents

Electronic control system of biochemical analyzer Download PDF

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Publication number
CN105068574A
CN105068574A CN201510495621.6A CN201510495621A CN105068574A CN 105068574 A CN105068574 A CN 105068574A CN 201510495621 A CN201510495621 A CN 201510495621A CN 105068574 A CN105068574 A CN 105068574A
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circuit
control
module
arm
chip
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CN201510495621.6A
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张光富
吴思远
鲁娉
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Hunan City University
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Hunan City University
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Abstract

The invention discloses an electronic control system of a biochemical analyzer. The electronic control system is small in size, simple and easy to operate, fast in analysis speed and high in precision. The electronic control system comprises an ARM control chip, a display module, a keyboard module, a stepping motor module, a constant temperature control module, a liquid path control module, an optical path control module, an I2C bus and a power supply. The ARM control chip is used as a central processing unit of the system to operate, control and manage the electronic control system along with an embedded type operating system. The stepping motor driving module regulates and controls the movement of a motor in a liquid path system according to an instruction sent out by an ARM through an A3911SED subdivided stepping motor driving chip. The constant temperature control module performs temperature measurement by use of an NTC thermistor sensor contrast color cup and controls reaction temperature of a sample along with a Fuzzy-intelligent PID composite control algorithm highly precisely. The liquid path control module is used for controlling the rotating disc, a stirring arm, sampling of biochemical reaction mixture and cleaning of related vessels. The optical path control module is used for measuring and controlling an optical scale division system and acquisition of biochemical reaction output signals.

Description

A kind of Biochemical Analyzer electronic control system
Technical field
The present invention relates to field of intelligent control, be specifically related to a kind of Biochemical Analyzer electronic control system.
Background technology
Biochemical Analyzer is the conventional instrument utilizing light absorption principle to carry out Multiple biomarkers in human body blood and body fluid, and the medical treatment being widely used in each hospital detects; There are the problems such as analysis speed is slow, precision is poor, automaticity is low in the Biochemical Analyzer of Present Domestic; The electronic control system of Biochemical Analyzer realizes whole instrument real time implementation to monitor with the core component of manipulation, also bear the vital task communicated with upper PC, is the guarantee of whole biochemical instruments automaticity; The electronic control system of current domestic Biochemical Analyzer needs many microcontroller chips to realize, and causes electronic control system relatively complicated, too increases chance and operating cost that data analysis and instrument manipulation time, instrument break down.
In addition, Biochemical Analyzer is when carrying out biochemical indicator and measuring, and in cuvette, all kinds of biochemical reactions of sample are to temperature fluctuation quite sensitive, can only could to obtain reliably at a constant temperature, Measurement and analysis result accurately.Therefore, the electronic control system contrast colors cup temperature of Biochemical Analyzer carry out high-precision measurement and thermostatic control display particularly important; Current biochemical instruments temperature monitoring system mainly adopts platinum resistance thermometer sensor, Pt100 to carry out temperature monitoring, but device can make self-heating because of excessive by electric current and introduce error; Although small signal amplification circuit can be added to reduce error before A/D converter part, also increase the complexity of head temperature Acquisition Circuit simultaneously, reduce the effect of high accuracy temperature control.
Summary of the invention
The object of the invention is to solve the problems of the prior art, providing that one is simple, easy to operate, analysis speed is fast, the electronic control system of high-precision Biochemical Analyzer.
Specific embodiment of the invention scheme adopts ARM control chip, and arrange in pairs or groups strong, debugging in order, the electronic control system of embedded OS to Biochemical Analyzer that can realize real-time multi-task management manipulates and manage; Utilize that temperature-coefficient of electrical resistance is large, thermal inertia is little, the NTC thermistor sensor contrast colors cup of fast response time carries out real time temperature measurement, arrange in pairs or groups simultaneously and carry out thermostatic control based on Fuzzy-PID control algolithm contrast colors cup.
The invention provides a kind of Biochemical Analyzer electronic control system, comprise ARM control chip, display module, Keysheet module, I 2c bus, stepper motor module, thermostatic control module, light path control module, fluid path control module, power supply.
Described ARM control chip is the core of whole electronic control system, be responsible for the scheduling and controlling of whole Biochemical Analyzer system task, comprise self-inspection when Biochemical Analyzer starts, monitoring fluid path state, the motion controlling stepper motor in fluid path control circuit, monitoring light path system state, the work of instruction photometer, regulation and control thermostatic control, receive the order etc. of image data and upper PC.
Described display module comprises ST7920 Chinese Graphic Liquid Crystal Module driving governor and LCD display, under ST7920 controller drives cooperation, can realize 256 × 32 Dot-Matric LCD Display.
Described Keysheet module comprises ZLG7290 keyboard scan chip and 8 × 8 keyboards.
Described I 2c bus is mainly used in the communication of ARM control chip and upper PC.
Described stepper motor module is formed primarily of driving circuit and stepper motor, and the realization of driving circuit adopts A3977SED to segment stepper motor driver chip.
Described thermostatic control module comprises high-resolution hydrocode circuit and constant temperature control circuit; High-resolution hydrocode circuit is made up of constant current source, NTC thermistor sensor, amplifying circuit, LTC2400A/D conversion chip and photoelectric isolating circuit; Constant temperature control circuit comprises photoelectric isolating circuit, driving circuit, controllable silicon, refrigerator and heating.
Described light path control module is made up of optics indexing system (comprising light source, preposition optical system, cuvette, rearmounted optical system, monochromator), photodetector, linear amplifier circuit, analog switch, logarithmic operational circuit, A/D change-over circuit.
Described fluid path control system comprises rotating disk control section, mixing arm control section, sampling and cleaning control part; Rotating disk control section by locating light idol, reel number identification Hall element, rotary tray motor form; Mixing arm control section by locating light idol, liquid level sensor, striker protection circuit, mixing arm oscillating motor form; Sampling and cleaning control part are formed by locating light idol, cleaning threshold on-off circuit and injection sample motor.
Described power module is mainly automatic analyzer and provides power supply, comprises rectification, voltage stabilizing, filtering, denoising, electromagnetic compatibility circuit.
Beneficial effect of the present invention is, the Biochemical Analyzer electronic control system provided, be adopt ARM control chip, arrange in pairs or groups strong, debugging in order, the electronic control system of embedded OS to Biochemical Analyzer that can realize real-time multi-task management manipulates and manages; The instruction that the motor drive module of electronic control system is sent by ARM segments stepper motor driver chip through A3977SED can the motor movement of each control section in Effective Regulation liquid-way system, and without the need to dividing chip controls to each motor; The thermostatic control system of electronic control system utilizes that temperature-coefficient of electrical resistance is large, thermal inertia is little, the NTC thermistor sensor contrast colors cup of fast response time carries out real time temperature measurement, arrange in pairs or groups simultaneously and carry out thermostatic control based on Fuzzy-intelligent PID complex control algorithm contrast colors cup, high precision can control the temperature of reaction of sample in cuvette; Because electronic system is by single ARM control chip concentrated controling management, and the Resources on Chip that these integrated chip timing, counter, storeies etc. are abundant, there is the various advantages such as travelling speed is fast; In addition, NTC thermistor sensor, Fuzzy-PID control algolithm are the accuracy that Biochemical Analyzer provides that high-accuracy and constant temperature control system can improve analysis of biochemical index; Therefore, namely this electronic control system has the advantages such as spatial volume is little, simple to operation, analysis speed is fast, can improve again the accuracy of Biochemical Analyzer.
Accompanying drawing explanation
Figure 1 shows that mesophytization analyser electronic control system block diagram of the present invention.
Figure 2 shows that Design of Stepper Motor Subdivision chip circuit figure in the present invention.
Figure 3 shows that thermostatic control module frame chart in the present invention.
Figure 4 shows that constant-current source circuit figure in the present invention.
Figure 5 shows that high-resolution hydrocode circuit in the present invention.
Figure 6 shows that Fuzzy-intelligent PID complex control algorithm schematic diagram in the present invention.
Figure 7 shows that light path control module frame chart in the present invention.
Figure 8 shows that fluid path control module block diagram in the present invention.
Figure 9 shows that thermostatic control program flow diagram in the present invention.
Embodiment
Hereafter will describe the specific embodiment of the invention in detail in conjunction with concrete accompanying drawing.It should be noted that the combination of technical characteristic or the technical characteristic described in following embodiment should not be considered to isolated, they can mutually be combined thus be reached better technique effect.
As shown in Figure 1, the invention provides a kind of Biochemical Analyzer electronic control system, comprising: power supply 1, ARM control chip 2, display module 3, Keysheet module 4, I 2c bus 5, stepper motor module 6, thermostatic control module 7, light path control module 8, fluid path control module 9.
Power supply 1 comprises rectification, voltage stabilizing, filtering, denoising, electromagnetic compatibility circuit, is mainly used in the power supply supply of automatic analyzer electronic control system.
ARM control chip 2 adopts the ARM chip of ARM+DSP structure, there is superpower mathematical operation function, it is the control core of whole Biochemical Analyzer electronic control system, collocation UCLinux embedded OS controls driving stepper motor module, thermostatic control module, light path control module, fluid path control module in real time, completes the data acquisition of Biochemical Analyzer and communicating of host computer simultaneously.
Display module 3 utilizes ST7920 Chinese Graphic Liquid Crystal Module driving governor to drive LCD display, under ST7920 controller drives cooperation, can realize 256 × 32 Dot-Matric LCD Display; For analyser steering order display estranged and Monitoring Data display.
Keysheet module 4 passes through I 2c bus connection ZLG7290 keyboard scan chip and ARM control chip complete data and transmit, and can realize 8 × 8 keyboard operations, input for steering order data.
I 2c bus 5 is mainly used in the data communication of ARM control chip and host computer.
Stepper motor module 6 is made up of driving circuit and stepper motor, and the realization of driving circuit adopts A3977SED to segment stepper motor driver chip, comprises heat shutoff, under-voltage locking and cross protection circuit; Export by dual H-bridge circuit realiration, stepper motor chip sub-circuit figure as shown in Figure 2; Stepper motor adopts opened loop control everywhere, the optoelectronic switch that stepper motor motion initial position is made up of photoelectrical coupler gathers stepper motor movement position signal, and after filtering after debounce processing, send into ARM control chip, ARM control chip stored position information, and make corresponding instruction according to positional information.
Thermostatic control module 7 comprises high-resolution hydrocode circuit and constant temperature control circuit; Thermostatic control module frame chart as shown in Figure 3; This module is first by input through keyboard target temperature expected value and bound (or directly given by upper PC), NTC thermistor sensor starts simultaneously, actual temperature in Real-Time Monitoring cuvette is also converted into voltage signal, is transported in ARM control chip by A/D conversion; When actual temperature is lower than target temperature, ARM control chip sends the work of order-driven heater circuit and elevates the temperature, otherwise, drive refrigeration circuit work, temperature is reduced; Finally show in display module 3 pairs of temperature; In order to prevent suppressing system noise, eliminating the interference of ground loop, in temperature survey and constant temperature control circuit, all adding photoelectric isolating circuit; High-resolution hydrocode circuit is made up of constant current source, NTC thermistor sensor, amplifying circuit, LTC2400A/D conversion chip and photoelectric isolating circuit; As shown in Figure 4, signal is amplified twice to constant-current source circuit by amplifier U2A, and amplifier U2B is a voltage follower, R 2and R 9reference resistance two ends dividing potential drop and the reference voltage of composition are invariable, and output current keeps constant; Constant current source is mainly used in NTC thermistor sensor and provides power supply; High-resolution hydrocode circuit as shown in Figure 5, by NTC thermistor sensor, is placed on circuit, 24 modulus conversion chip LTC2400 and photoelectric isolating circuit and forms, constant current source and sample resistance R refreference voltage is provided for A/D changes LTC2400 v rEF , form ratio measuring system with surveyed thermistor both end voltage; Adopt 24 high precision analogue conversion resolutions because A/D changes LTC2400, this detecting temperature precision can be made to reach 0.01 0c; Constant temperature control circuit comprises photoelectric isolating circuit, driving circuit, controllable silicon, refrigerator and heating.Temperature-controlled process adopts Fuzzy-intelligent PID complex control algorithm, and its schematic diagram as shown in Figure 6.In order to improve control accuracy, rationally applying controlled quentity controlled variable, shortening the control time, reducing the impact of the factor such as delayed, addition of temperature variation prediction.Temperature prediction formula, as shown in formula (1), is considering, on the hypothesis basis that temperature is continuous gradual amount, large step controlled quentity controlled variable also can not make temperature undergo mutation, to utilize t k moment point is to temperature variable in time t( t) carry out Taylor expansion calculating acquisition, kfor temperature control cycle number; Show that temperature prediction can obtain more excellent control result through matlab simulation result.
(1)
Fuzzy-intelligent PID combined temp control algolithm is based on Fuzzy fuzzy control theory and Intelligent PID Control strategy, finds out controling parameters k p (ratio controlling elements), K i(the integration control factor), k d(derivative control factors) and input quantity e(deviation between target temperature and observed temperature), e c ( ethe rate of change of deviation) between relation, realize the real-time correction of three controling parameters.First provide basic PID parameter by the Fuzzy fuzzy controller of input quantity, carry out state analysis according to basic parameter, differential control item and current state, binding analysis result carries out intelligence correction to PID parameter; Basic controlling algorithmic formula as shown in (2) formula, in formula e k , e k-1 be respectively the deviation of current and upper one-period, t 0 for control cycle, t f for the incomplete differential time, t d k with t d k-1 be respectively the temperature controlled quentity controlled variable that current period and upper one-period are obtained by differential algorithm.
(2)
Light path control module 8 is made up of optics indexing system (comprising light source, preposition optical system, cuvette, rearmounted optical system, monochromator), photodetector, linear amplifier circuit, analog switch, logarithmic operational circuit, A/D change-over circuit; Its theory diagram as shown in Figure 7; Biochemical Analyzer electronic control system is mainly monitored photodetector, linear amplifier circuit, analog switch, logarithmic operational circuit, A/D change-over circuit; Photodetector adopts silicon photodiode array detector, and what photodetector exported is weak current signal, is amplified and convert voltage signal to by linear amplifier circuit, removes the impact of dark current; ARM control chip is monitored analog switch; Photodetection signal is converted to the absorbance value of sample by logarithmic operational circuit; Through A/D change-over circuit to ARM control chip conveying digital signal.
Fluid path control module 9, comprises rotating disk control section, mixing arm control section, sampling and cleaning control part; Its block diagram as shown in Figure 8; Rotating disk control section determines to inhale sample dish position by a zero-bit location optocoupler, another two location optocouplers determine Internal and external cycle hole site respectively, determined to sample reel number by Hall element, these information obtained are sent in AMR control chip, and Driving Stepping Motor rotates suction sample dish; The location optocoupler of mixing arm control section is arm swing zero-bit and arm lifting zero-bit, liquid level sensor perception sample liquid level, and striker protection does not collide for the protection of pin and arm, and stepper motor is for manipulating the motion of mixing arm; Sampling and cleaning control part, location optocoupler, for determining the zero-bit of the zero-sum sample needle of syringe, rinses the cleaning that threshold is used for needle tubing inside and outside wall, when magnet-valve switch opens, high pressure swash of wave current rinse needle tubing, and stepper motor is for controlling syringe piston motion.
Embodiment:
The embodiment of the present application provides a kind of Biochemical Analyzer electronic control system, is to adopt ARM control chip, and the electronic control system of embedded OS to Biochemical Analyzer that collocation can realize real-time multi-task management manipulates and manage; Comprise the monitor and managment to fluid path control system, light path control system, thermostatic control system and stepper motor in Biochemical Analyzer.
To arrange in pairs or groups in Biochemical Analyzer electronic control system UCLinux embedded OS, utilize the coordination application of function and action between the control of completion system under the assistance of bottom module and control system driver, hardware, concrete Software for Design is compiled together with control system driver task with bottom module by the operating system code transplanted, and compiled object code is downloaded on Target Board by jtag interface and runs debugging; According to principle of work and the function control of Biochemical Analyzer, control system is divided into keyboard task, display task, fluid path control task (comprising sampling task, cuvette reaction tray task, flushing task), light path control task, thermostatic control task, step motor control task; Automatic analyzer runs under the automatic control of ARM control chip, and after system electrification, the first initialization of each functional module, completes self-inspection; Operating personnel are at host computer operation interface interface input test parameter, install sample, electronic control system instructs fluid path control system to clean cuvette, filling reagent and sample, Driving Stepping Motor are uniformly mixed liquid, drive thermostatic control system and light path control system cloud gray model, completing optical measurement, the information simultaneously exported light path control system carries out filtering, except the signal transacting such as making an uproar, and the data upload obtained being carried out analyzing and processing to host computer.
The realization of stepper motor module 6 driving circuit adopts A3977SED to segment stepper motor driver chip, input and realized by " DIR " (direction) and " STEP " (stepping) two-wire, export and realized by H-bridge circuit, current of electric has fixing OFF time PWM (pulse-length modulation) control circuit to adjust, by changing the current phase relation in motor coil, direction of motor rotation can be changed; When driving chip detects the clock signal (CLK) that ARM control chip is sent here and direction signal (DIR), driving governor is translated into electric current and the direction of A phase and B phase driver, thus realizes mini-step controlling;
Thermostatic control module 7 comprises high-resolution hydrocode circuit and constant temperature control circuit; Control program process flow diagram as shown in Figure 9; Initialization mainly carries out initialization to each equipment and variable, and system components is ready; By input through keyboard set temperature value (or given by upper PC) and bound temperature (as: 37 ± 0.05 0c); Start-up temperature metering circuit carries out temperature acquisition; Judge whether temperature equals to envision temperature; If equal to envision temperature actuated display module 3 to carry out Temperature displaying, if be not equal to anticipation temperature, start Fuzzy-intelligent PID composite algorism controller, export PWM waveform regulation and control rear end executive circuit, utilize controllable silicon to regulate and control temperature, 10ms is postponed after regulation and control, again carry out temperature acquisition, until temperature equals to envision temperature, and show.
Light path control module 8, Biochemical Analyzer electronic control system is mainly monitored photodetector, linear amplifier circuit, analog switch, logarithmic operational circuit, A/D change-over circuit; Photodetector adopts silicon photodiode array detector, and what photodetector exported is weak current signal, is amplified and convert voltage signal to by linear amplifier circuit, removes the impact of dark current; ARM control chip is monitored simulation shape; Photodetection signal is converted to the absorbance value of sample by logarithmic operational circuit; Through A/D change-over circuit to ARM control chip conveying digital signal.
Fluid path control module 9, comprises rotating disk control section, mixing arm control section, sampling and cleaning control part; Rotating disk control section determines to inhale sample dish position by a zero-bit location optocoupler, another two location optocouplers determine Internal and external cycle hole site respectively, determined to sample reel number by Hall element, these information obtained are sent in AMR control chip, and Driving Stepping Motor rotates suction sample dish; The location optocoupler of mixing arm control section is arm swing zero-bit and arm lifting zero-bit, liquid level sensor perception sample liquid level, and striker protection does not collide for the protection of pin and arm, and stepper motor is for manipulating the motion of mixing arm; Sampling and cleaning control part, location optocoupler, for determining the zero-bit of the zero-sum sample needle of syringe, rinses the cleaning that threshold is used for needle tubing inside and outside wall, when magnet-valve switch opens, high pressure swash of wave current rinse needle tubing, and stepper motor is for controlling syringe piston motion.
A kind of Biochemical Analyzer electronic control system provided by the invention, although the application gives some embodiments of the present invention, but it will be understood by those of skill in the art that without departing from the spirit of the invention, can change the embodiment of the application.Above-described embodiment is exemplary, should restriction using the embodiment of the application as interest field of the present invention.

Claims (3)

1. a Biochemical Analyzer electronic control system, comprises ARM control chip, display module, Keysheet module, stepper motor module, thermostatic control module, fluid path control module, light path control module, I 2c bus and power supply;
Described ARM control chip adopts the ARM chip of ARM+DSP structure, there is superpower mathematical operation function, it is the control core of whole Biochemical Analyzer electronic control system, collocation UCLinux embedded OS controls driving stepper motor module, thermostatic control module, light path control module, fluid path control module in real time, completes the data acquisition of Biochemical Analyzer and communicating of host computer simultaneously;
The driving stepper motor module of described electronic control system to be the instruction that sent by ARM segment stepper motor driver chip through A3977SED can the motor movement of each control section in Effective Regulation liquid-way system, and without the need to dividing chip controls to each motor;
Described thermostatic control module comprises high-resolution hydrocode circuit and constant temperature control circuit; High-resolution hydrocode circuit is made up of constant current source, NTC thermistor sensor, amplifying circuit, LTC2400A/D conversion chip and photoelectric isolating circuit; Constant temperature control circuit comprises photoelectric isolating circuit, driving circuit, controllable silicon, refrigerator and heating;
Described fluid path control system comprises rotating disk control section, mixing arm control section, sampling and cleaning control part; Rotating disk control section by locating light idol, reel number identification Hall element, rotary tray motor form; Mixing arm control section by locating light idol, liquid level sensor, striker protection circuit, mixing arm oscillating motor form; Sampling and cleaning control part are formed by locating light idol, cleaning threshold on-off circuit and injection sample motor.
2. Biochemical Analyzer electronic control system as claimed in claim 1, it is characterized in that, high-resolution hydrocode circuit is made up of constant current source, NTC thermistor sensor, amplifying circuit, LTC2400A/D conversion chip and photoelectric isolating circuit; As shown in Figure 4, signal is amplified twice to constant-current source circuit by amplifier U2A, and amplifier U2B is a voltage follower, and reference resistance two ends dividing potential drop and the reference voltage of R2 and R9 composition are invariable, and output current keeps constant; Constant current source is mainly used in NTC thermistor sensor and provides power supply; High-resolution hydrocode circuit as shown in Figure 5, by NTC thermistor sensor, is placed on circuit, 24 modulus conversion chip LTC2400 and photoelectric isolating circuit and forms, constant current source and sample resistance R refreference voltage V is provided for A/D changes LTC2400 rEF, form ratio measuring system with surveyed thermistor both end voltage; Adopt 24 high precision analogue conversion resolutions because A/D changes LTC2400, this detecting temperature precision can be made to reach 0.01 0c.
3. Biochemical Analyzer electronic control system as claimed in claim 1, it is characterized in that, constant temperature control circuit comprises photoelectric isolating circuit, driving circuit, controllable silicon, refrigerator and heating; Temperature-controlled process adopts Fuzzy-intelligent PID complex control algorithm, and its schematic diagram as shown in Figure 6; In order to improve control accuracy, rationally applying controlled quentity controlled variable, shortening the control time, reducing the impact of the factor such as delayed, addition of temperature variation prediction.
CN201510495621.6A 2015-08-13 2015-08-13 Electronic control system of biochemical analyzer Pending CN105068574A (en)

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Publication number Priority date Publication date Assignee Title
CN105549458A (en) * 2015-12-04 2016-05-04 无锡中德伯尔生物技术有限公司 Automatic sample pre-treatment instrument control system
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CN111966138A (en) * 2020-06-30 2020-11-20 厦门大学 High-precision temperature control method and system for medical equipment
CN112462081A (en) * 2020-07-13 2021-03-09 广东国盛医学科技有限公司 Full-automatic biological sample preservation analysis control system
CN112304933A (en) * 2020-11-03 2021-02-02 南通市第一人民医院 Intelligent disinfectant colorimetric display control method and system
CN112304933B (en) * 2020-11-03 2021-09-21 南通市第一人民医院 Intelligent disinfectant colorimetric display control method and system

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