CN105056294B - A kind of sustained-release antibacterial absorbable medical suture and preparation method thereof - Google Patents
A kind of sustained-release antibacterial absorbable medical suture and preparation method thereof Download PDFInfo
- Publication number
- CN105056294B CN105056294B CN201510496155.3A CN201510496155A CN105056294B CN 105056294 B CN105056294 B CN 105056294B CN 201510496155 A CN201510496155 A CN 201510496155A CN 105056294 B CN105056294 B CN 105056294B
- Authority
- CN
- China
- Prior art keywords
- parts
- coating
- solution
- sustained
- warming
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000000844 anti-bacterial Effects 0.000 title claims abstract description 43
- 230000002459 sustained Effects 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title claims abstract description 37
- 239000011248 coating agent Substances 0.000 claims abstract description 94
- 238000000576 coating method Methods 0.000 claims abstract description 94
- 229920001661 Chitosan Polymers 0.000 claims abstract description 54
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims abstract description 50
- 102000008186 Collagen Human genes 0.000 claims abstract description 41
- 108010035532 Collagen Proteins 0.000 claims abstract description 41
- 229960005188 collagen Drugs 0.000 claims abstract description 41
- 229920001436 collagen Polymers 0.000 claims abstract description 41
- 238000007037 hydroformylation reaction Methods 0.000 claims abstract description 40
- 229920002472 Starch Polymers 0.000 claims abstract description 34
- 235000019698 starch Nutrition 0.000 claims abstract description 34
- 239000008107 starch Substances 0.000 claims abstract description 34
- 239000000835 fiber Substances 0.000 claims abstract description 33
- 210000003491 Skin Anatomy 0.000 claims abstract description 22
- 210000000988 Bone and Bones Anatomy 0.000 claims abstract description 21
- 241000282898 Sus scrofa Species 0.000 claims abstract description 20
- 241000252230 Ctenopharyngodon idella Species 0.000 claims abstract description 19
- IBFYXTRXDNAPMM-BVTMAQQCSA-N Geniposide Chemical compound O([C@@H]1OC=C([C@@H]2[C@H]1C(=CC2)CO)C(=O)OC)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O IBFYXTRXDNAPMM-BVTMAQQCSA-N 0.000 claims abstract description 19
- IBFYXTRXDNAPMM-LXPWSASLSA-N Geniposide Natural products O=C(OC)C=1[C@@H]2[C@H]([C@@H](O[C@H]3[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)OC=1)C(CO)=CC2 IBFYXTRXDNAPMM-LXPWSASLSA-N 0.000 claims abstract description 19
- BDNKZNFMNDZQMI-UHFFFAOYSA-N N,N'-Diisopropylcarbodiimide Chemical compound CC(C)N=C=NC(C)C BDNKZNFMNDZQMI-UHFFFAOYSA-N 0.000 claims abstract description 19
- 241000269811 Pagrus pagrus Species 0.000 claims abstract description 19
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 19
- 235000011187 glycerol Nutrition 0.000 claims abstract description 19
- 235000012424 soybean oil Nutrition 0.000 claims abstract description 19
- 239000003549 soybean oil Substances 0.000 claims abstract description 19
- 238000009954 braiding Methods 0.000 claims abstract description 18
- MWOOGOJBHIARFG-UHFFFAOYSA-N Vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 claims abstract description 16
- FBPFZTCFMRRESA-KAZBKCHUSA-N D-Mannitol Natural products OC[C@@H](O)[C@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KAZBKCHUSA-N 0.000 claims abstract description 12
- FBPFZTCFMRRESA-KVTDHHQDSA-N Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 12
- 239000000594 mannitol Substances 0.000 claims abstract description 12
- 235000010355 mannitol Nutrition 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 10
- 239000000243 solution Substances 0.000 claims description 80
- 238000010792 warming Methods 0.000 claims description 47
- JDLKFOPOAOFWQN-VIFPVBQESA-N Allicin Natural products C=CCS[S@](=O)CC=C JDLKFOPOAOFWQN-VIFPVBQESA-N 0.000 claims description 46
- 238000003756 stirring Methods 0.000 claims description 41
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 36
- 239000000661 sodium alginate Substances 0.000 claims description 26
- 235000010413 sodium alginate Nutrition 0.000 claims description 24
- 229940005550 Sodium alginate Drugs 0.000 claims description 23
- 235000010081 allicin Nutrition 0.000 claims description 23
- MSXHSNHNTORCAW-UHFFFAOYSA-M sodium 3,4,5,6-tetrahydroxyoxane-2-carboxylate Chemical compound [Na+].OC1OC(C([O-])=O)C(O)C(O)C1O MSXHSNHNTORCAW-UHFFFAOYSA-M 0.000 claims description 23
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 21
- 239000006210 lotion Substances 0.000 claims description 20
- 239000007864 aqueous solution Substances 0.000 claims description 18
- HMFKFHLTUCJZJO-UHFFFAOYSA-N 2-{2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy}ethyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCOCC(OCCO)C1OCC(OCCO)C1OCCO HMFKFHLTUCJZJO-UHFFFAOYSA-N 0.000 claims description 17
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 17
- NWGKJDSIEKMTRX-NZAQQJATSA-N [2-[(2R,3S,4R)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] (Z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)[C@H]1OC[C@@H](O)[C@@H]1O NWGKJDSIEKMTRX-NZAQQJATSA-N 0.000 claims description 17
- 239000004594 Masterbatch (MB) Substances 0.000 claims description 16
- 238000007792 addition Methods 0.000 claims description 10
- 239000012065 filter cake Substances 0.000 claims description 10
- 238000001816 cooling Methods 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- 238000005453 pelletization Methods 0.000 claims description 8
- 230000001954 sterilising Effects 0.000 claims description 8
- 239000000155 melt Substances 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 4
- 238000007873 sieving Methods 0.000 claims description 3
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000003115 biocidal Effects 0.000 abstract description 8
- 210000001519 tissues Anatomy 0.000 abstract description 6
- 230000000845 anti-microbial Effects 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 235000009508 confectionery Nutrition 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- 238000001035 drying Methods 0.000 description 6
- 241000251468 Actinopterygii Species 0.000 description 5
- 240000002234 Allium sativum Species 0.000 description 5
- 235000004611 garlic Nutrition 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 238000005303 weighing Methods 0.000 description 4
- 200000000019 wound Diseases 0.000 description 4
- 150000001299 aldehydes Chemical class 0.000 description 3
- 201000009910 diseases by infectious agent Diseases 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 230000029663 wound healing Effects 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 235000009499 Vanilla fragrans Nutrition 0.000 description 2
- 240000006722 Vanilla planifolia Species 0.000 description 2
- 235000012036 Vanilla tahitensis Nutrition 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 240000000218 Cannabis sativa Species 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- LEQAOMBKQFMDFZ-UHFFFAOYSA-N Glyoxal Chemical compound O=CC=O LEQAOMBKQFMDFZ-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 201000005794 allergic hypersensitivity disease Diseases 0.000 description 1
- 230000003110 anti-inflammatory Effects 0.000 description 1
- 230000002421 anti-septic Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000001488 breeding Effects 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000001413 cellular Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- 230000000875 corresponding Effects 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000004059 degradation Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 230000002757 inflammatory Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000002194 synthesizing Effects 0.000 description 1
Abstract
The invention discloses a kind of sustained-release antibacterial absorbable medical suture, raw material includes by weight：80 100 parts of carboxymethyl chitosan, 10 15 parts of red porgy fish skin collagen, 8 12 parts of grass carp ossein, 10 20 parts of pig bone collagen, 13 parts of mannitol, 13 parts of epoxidized soybean oil, 13 parts of glycerine, 23 parts of vanillic aldehyde, 12 parts of Geniposide, 24 parts of diisopropylcarbodiimide, 0.5 1 parts of hydroformylation starch, 15 parts of coating.The invention also discloses the preparation methods of above-mentioned sustained-release antibacterial absorbable medical suture, include the following steps：S1, suture line fiber is prepared；S2, prepares coating solution；S3, coating braiding.Anti-microbial property of the present invention is good, can long acting antibiotic, good with biological tissue compatibility, cell is adhered to and bred easily in the present invention, easy to operate, low in the pollution of the environment, beneficial to industrialized production.
Description
Technical field
The present invention relates to suture technical field more particularly to a kind of sustained-release antibacterial absorbable medical suture and its
Preparation method.
Background technology
Operation suture thread refers among surgical operation, for one kind of wound ligation, Suture hemostasis and tissue apposition
It is special to use line.Two classes can be divided into according to its biodegradability：Nonabsorable line and absorbable thread.Absorbable thread suture includes
Natural fiber and synthesis high score subclass suture.
Chitosan is natural fiber class suture, good biocompatibility, itself has bacteriostasis, have chemical inertness,
The advantages that tissue foreign reaction, stimulation, allergy, inflammation can be not likely to produce by human body absorbed themselves, accelerating wound healing,
And wound is smooth after having many advantages, such as anti-inflammatory, promotion wound healing, healing, but chitosan bad mechanical property, and solubility property is not
It is good.Carboxymethyl chitosan is chitosan derivatives, good water solubility, and antibiotic property is strong.
Even notch skin splits etc. is the most common clinic of surgery for surgical incision skin structure infections, inflammatory exudation
One of problem.Suture is present in as a kind of foreign matter in incision tissue, and skin histology is easily made to generate inflammatory reaction, sutured
Wound be highly susceptible to bacterium infection in body ambient enviroment, and wound is caused to extend healing cycle because of bacterium infection, because
This needs to provide a kind of suture with long-acting slow-release antibacterial action.
The content of the invention
Technical problems based on background technology, the present invention propose a kind of sustained-release antibacterial absorbable medical suture and
Its preparation method, anti-microbial property of the present invention is good, can long acting antibiotic, good with biological tissue compatibility, cell is easily in the present invention
Adherency and breeding, it is easy to operate, it is low in the pollution of the environment, beneficial to industrialized production.
A kind of sustained-release antibacterial absorbable medical suture proposed by the present invention, raw material include by weight：Carboxymethyl shell
80-100 parts of glycan, 10-15 parts of red porgy fish skin collagen, 8-12 parts of grass carp ossein, 10-20 parts of pig bone collagen, mannitol 1-3
Part, 1-3 parts of epoxidized soybean oil, 1-3 parts of glycerine, 2-3 parts of vanillic aldehyde, 1-2 parts of Geniposide, 2-4 parts of diisopropylcarbodiimide, aldehyde
Change 0.5-1 parts of starch, 1-5 parts of coating；
Wherein, the preparation method of coating is：Allicin, Arlacel-80, Tween-60 are added in into carboxymethyl chitosan solution
In, it heats up, stirring obtains lotion；Temperature is adjusted, lotion and sodium alginate soln are added dropwise in water simultaneously, during dropwise addition
It is stirred continuously, continues to stir, heat up, add in hydroformylation starch solution, stir to get solution A；The pH of solution A is adjusted, heating is stirred
It mixes, cools down, stand, filter to obtain filter cake, dry, sieving obtains coating.
Preferably, the preparation method of coating is：Allicin, Arlacel-80, Tween-60 addition carboxymethyl chitosan is molten
In liquid, 50-60 DEG C is warming up to, stirring obtains lotion；Adjust the temperature to 10-15 DEG C, by lotion and sodium alginate soln respectively with
The speed of 1-2ml/min is added dropwise in water simultaneously, is stirred continuously during being added dropwise, and is continued to stir 20-30min, is warming up to 20-30
DEG C, hydroformylation starch solution is added in, stirring 20-40min obtains solution A, adjusts the pH=6-7 of solution A, stirs 20-40min, rises
Temperature stirs 40-60min to 50-60 DEG C, is cooled to 20-30 DEG C, and standing filters to obtain filter cake, is warming up to 40-50 DEG C, dry, sieving
Obtain coating.
Preferably, the preparation method of coating is：Allicin, Arlacel-80, Tween-60 addition carboxymethyl chitosan is molten
In liquid, 50-60 DEG C is warming up to, 50-90s is stirred with the speed of 9000-10000r/min, obtains lotion；Adjust the temperature to 10-15
DEG C, lotion and sodium alginate soln are added dropwise in water simultaneously with the speed of 1-2ml/min respectively, with 700- during dropwise addition
The speed stirring of 900r/min, continues to stir 20-30min, is warming up to 20-30 DEG C, hydroformylation starch solution is added in, with 700-
The speed stirring 20-40min of 900r/min obtains solution A, the pH=6-7 of solution A is adjusted with sodium hydroxide solution, with 700-
The speed stirring 20-40min of 900r/min, is warming up to 50-60 DEG C, continues to stir 40-60min, be cooled to 20-30 DEG C, stand
Filter cake is filtered to obtain, is warming up to 40-50 DEG C, drying crosses 200-400 mesh sieves and obtains coating.
Preferably, in the preparation method of coating, carboxymethyl chitosan solution is that mass fraction is 1-3wt% carboxymethyl shells
Water solution.
Preferably, in the preparation method of coating, Allicin, Arlacel-80, the weight ratio of Tween-60 are 1-2：0.12-
0.24：0.12-0.24.
Preferably, in the preparation method of coating, the bulking value (g/ml) of Allicin and carboxymethyl chitosan solution
Than for 1-2：40-60.
Preferably, in the preparation method of coating, sodium alginate soln is that mass fraction is that 1-3wt% sodium alginates are water-soluble
Liquid.
Preferably, in the preparation method of coating, carboxymethyl chitosan solution, sodium alginate soln, water, hydroformylation starch are molten
The volume ratio of liquid is 40-60：80-120：100-120：30-40.
Preferably, in the preparation method of coating, hydroformylation starch solution is the hydroformylation starch water that mass fraction is 1-5wt%
Solution.
Preferably, raw material includes by weight：85-95 parts of carboxymethyl chitosan, 12-14 parts of red porgy fish skin collagen, grass
9-11 parts of fish bone collagen, 13-17 parts of pig bone collagen, 1.5-2.5 parts of mannitol, 1.5-2.5 parts of epoxidized soybean oil, glycerine 1.5-
2.5 parts, 2.2-2.8 parts of vanillic aldehyde, 1.3-1.7 parts of Geniposide, 2.5-3.5 parts of diisopropylcarbodiimide, hydroformylation starch 0.6-
0.8 part, 2-4 parts of coating.
Preferably, raw material includes by weight：90 parts of carboxymethyl chitosan, 13 parts of red porgy fish skin collagen, grass carp gelatine
It is 10 parts former, 15 parts of pig bone collagen, 2 parts of mannitol, 2 parts of epoxidized soybean oil, 2 parts of glycerine, 2.5 parts of vanillic aldehyde, 1.5 parts of Geniposide,
3 parts of diisopropylcarbodiimide, 0.7 part of hydroformylation starch, 3 parts of coating.
The invention also provides the preparation methods of above-mentioned sustained-release antibacterial absorbable medical suture, include the following steps：
S1, suture line fiber is prepared：By carboxymethyl chitosan, red porgy fish skin collagen, grass carp ossein, pig bone collagen, sweet
Reveal alcohol, epoxidized soybean oil, glycerine, vanillic aldehyde, Geniposide, diisopropylcarbodiimide mixing, 90-100 DEG C is warming up to, with 100-
The speed stirring 2-3h of 300r/min, is squeezed out, water cooling with double screw extruder, air-dried, pelletizing obtains master batch；It is warming up to 120-
140 DEG C melt master batch, and deaeration obtains primary filament by spinneret；Primary filament is stretched in 40-60 DEG C of water-bath,
Obtain suture line fiber；
S2, prepares coating solution：Hydroformylation starch, coating are added in 40-50 parts of water, stirred with the speed of 600-800r/min
20-30min is mixed, obtains coating solution；
S3, coating braiding：Coating treatment is carried out to the suture line fiber obtained in S1 with the coating solution obtained in S2, is dried in the air
Dry, braiding, sterilizing obtains sustained-release antibacterial absorbable medical suture.
" spinneret " in above-mentioned S1 has different apertures, and specification should be needed to select corresponding aperture according to production.
The carboxymethyl chitosan that the present invention selects generates a large amount of positively charged primary amino radicals in aqueous solution, and sodium alginate is molten
A large amount of negatively charged carboxyls are formed after Xie Yushui, carboxymethyl chitosan forms poly- with sodium alginate by positive and negative charge attraction
Dielectric film, electrostatic interactions are a kind of very weak active forces, and high temperature and thermo-crosslinking process is not required, reduces the present invention
Energy consumption；Allicin plays an important role of broad-spectrum antiseptic, and carboxymethyl chitosan is reacted by electrostatic with sodium alginate and in hydroformylation
Allicin is wrapped in carboxymethyl chitosan-sodium alginate under the crosslinked action of starch, Allicin is made slowly to discharge, is reached
To the effect of long acting antibiotic, it is wrapped in carboxymethyl chitosan-sodium alginate outside Allicin and passes through hydroformylation starch and suture
Line fiber is crosslinked, coated in suture fiber surface, so as to considerably increase the sustained-release antibacterial performance of the present invention；Carboxymethyl chitosan
Sugar-sodium alginate and the compatibility for suturing line fiber are good, can be good at being adhered on suture line fiber, so as to further increase
The sustained-release antibacterial performance of the present invention；This province of carboxymethyl chitosan has certain antibacterial action, so as to add the anti-of the present invention
Bacterium performance；Suture line fiber, coating have good cell compatibility, and cell can be very good to breed in adherency in suture；
Red porgy fish skin collagen, grass carp ossein, pig bone collagen can promote wound healing；Geniposide, diisopropylcarbodiimide can be with
Promote carboxymethyl chitosan and red porgy fish skin collagen, grass carp ossein, the copolymerization of pig bone collagen, increase the present invention mechanical strength and
Cellular affinity；Mannitol, epoxidized soybean oil, glycerine can increase the stability of the present invention；Vanillic aldehyde can increase the present invention
Antibiotic property；Braiding structure is close, will not generate sub-wire phenomenon, further increases the mechanical performance and degradation resistance of the present invention
Energy；With coating on suture line fiber, bacterium can be prevented to be concealed in hole is woven, increase the biocidal property of the present invention；It applies
Layer can increase the slickness of the present invention, reduce tissue drag force, reduce the pain brought during suture to patient；Present invention operation letter
It is single, organic solvent is not used, it is low in the pollution of the environment, beneficial to industrial production.
Description of the drawings
Fig. 1 is a kind of process flow chart of the preparation method of sustained-release antibacterial absorbable medical suture proposed by the present invention.
Specific embodiment
As shown in Figure 1, Fig. 1 is a kind of work of the preparation method of sustained-release antibacterial absorbable medical suture proposed by the present invention
Skill flow chart.
With reference to Fig. 1, a kind of preparation method of sustained-release antibacterial absorbable medical suture proposed by the present invention, including walking as follows
Suddenly：
S1, suture line fiber is prepared：By carboxymethyl chitosan, red porgy fish skin collagen, grass carp ossein, pig bone collagen, sweet
Reveal alcohol, epoxidized soybean oil, glycerine, vanillic aldehyde, Geniposide, diisopropylcarbodiimide mixing, 90-100 DEG C is warming up to, with 100-
The speed stirring 2-3h of 300r/min, is squeezed out, water cooling with double screw extruder, air-dried, pelletizing obtains master batch；It is warming up to 120-
140 DEG C melt master batch, and deaeration obtains primary filament by spinneret；Primary filament is stretched in 40-60 DEG C of water-bath,
Obtain suture line fiber；
S2, prepares coating solution：Hydroformylation starch, coating are added in 40-50 parts of water, stirred with the speed of 600-800r/min
20-30min is mixed, obtains coating solution；
S3, coating braiding：Coating treatment is carried out to the suture line fiber obtained in S1 with the coating solution obtained in S2, is dried in the air
Dry, braiding, sterilizing obtains sustained-release antibacterial absorbable medical suture.
In the following, technical scheme is described in detail by specific embodiment.
Embodiment 1
A kind of sustained-release antibacterial absorbable medical suture, raw material include by weight：80 parts of carboxymethyl chitosan, red porgy
15 parts of fish skin collagen, 8 parts of grass carp ossein, 20 parts of pig bone collagen, 1 part of mannitol, 3 parts of epoxidized soybean oil, 1 part of glycerine, vanilla
3 parts of aldehyde, 1 part of Geniposide, 4 parts of diisopropylcarbodiimide, 0.5 part of hydroformylation starch, 5 parts of coating；
Wherein, the preparation method of coating is：It is 1wt% carboxylics that Allicin, Arlacel-80, Tween-60 are added in mass fraction
In methyl chitosan aqueous solution, 60 DEG C are warming up to, 90s is stirred with the speed of 9000r/min, obtains lotion, wherein, garlic is new
Element, Arlacel-80, the weight ratio of Tween-60 are 1：0.24：0.12, the weighing body of Allicin and carboxymethyl chitosan sugar aqueous solution
Product (g/ml) is than being 2：40；Adjust the temperature to 15 DEG C, by lotion and mass fraction for 1wt% sodium alginate aqueous solutions respectively with
The speed of 2ml/min is added dropwise in water simultaneously, is stirred during dropwise addition with the speed of 700r/min, continues to stir 30min, heating
To 20 DEG C, the hydroformylation amidin that mass fraction is 5wt% is added in, solution is obtained with the speed stirring 40min of 700r/min
A adjusts the pH=6 of solution A with sodium hydroxide solution, stirs 20min with the speed of 900r/min, is warming up to 60 DEG C, continues to stir
40min to be mixed, is cooled to 30 DEG C, standing filters to obtain filter cake, is warming up to 40 DEG C, and drying crosses 400 mesh sieves and obtains coating, wherein, carboxylic first
Base chitosan solution, sodium alginate soln, water, the volume ratio of hydroformylation starch solution are 40：120：100：40.
The preparation method of above-mentioned sustained-release antibacterial absorbable medical suture, includes the following steps：
S1, suture line fiber is prepared：By carboxymethyl chitosan, red porgy fish skin collagen, grass carp ossein, pig bone collagen, sweet
Reveal alcohol, epoxidized soybean oil, glycerine, vanillic aldehyde, Geniposide, diisopropylcarbodiimide mixing, 90 DEG C are warming up to, with 300r/min
Speed stirring 2h, squeezed out with double screw extruder, water cooling, air-dry, pelletizing obtains master batch；Being warming up to 140 DEG C melts master batch,
Deaeration obtains primary filament by spinneret；Primary filament in 40 DEG C of water-bath is stretched, obtains suture line fiber；
S2, prepares coating solution：Hydroformylation starch, coating are added in 50 parts of water, stirred with the speed of 600r/min
30min obtains coating solution；
S3, coating braiding：Coating treatment is carried out to the suture line fiber obtained in S1 with the coating solution obtained in S2, is dried in the air
Dry, braiding, sterilizing obtains sustained-release antibacterial absorbable medical suture.
Embodiment 2
A kind of sustained-release antibacterial absorbable medical suture, raw material include by weight：100 parts of carboxymethyl chitosan, very
10 parts of madai collagen, 12 parts of grass carp ossein, 10 parts of pig bone collagen, 3 parts of mannitol, 1 part of epoxidized soybean oil, 3 parts of glycerine are fragrant
2 parts of oxalaldehyde, 2 parts of Geniposide, 2 parts of diisopropylcarbodiimide, 1 part of hydroformylation starch, 1 part of coating；
Wherein, the preparation method of coating is：It is 3wt% carboxylics that Allicin, Arlacel-80, Tween-60 are added in mass fraction
In methyl chitosan aqueous solution, 50 DEG C are warming up to, 50s is stirred with the speed of 10000r/min, obtains lotion, wherein, garlic is new
Element, Arlacel-80, the weight ratio of Tween-60 are 2：0.12：0.24, the weighing body of Allicin and carboxymethyl chitosan sugar aqueous solution
Product (g/ml) is than being 1：60；Adjust the temperature to 10 DEG C, by lotion and mass fraction for 3wt% sodium alginate aqueous solutions respectively with
The speed of 1ml/min is added dropwise in water simultaneously, is stirred during dropwise addition with the speed of 900r/min, continues to stir 20min, heating
To 30 DEG C, the hydroformylation amidin that mass fraction is 1wt% is added in, solution is obtained with the speed stirring 20min of 900r/min
A adjusts the pH=7 of solution A with sodium hydroxide solution, stirs 40min with the speed of 700r/min, is warming up to 50 DEG C, continues to stir
60min to be mixed, is cooled to 20 DEG C, standing filters to obtain filter cake, is warming up to 50 DEG C, and drying crosses 200 mesh sieves and obtains coating, wherein, carboxylic first
Base chitosan solution, sodium alginate soln, water, the volume ratio of hydroformylation starch solution are 60：80：120：30.
The preparation method of above-mentioned sustained-release antibacterial absorbable medical suture, includes the following steps：
S1, suture line fiber is prepared：By carboxymethyl chitosan, red porgy fish skin collagen, grass carp ossein, pig bone collagen, sweet
Reveal alcohol, epoxidized soybean oil, glycerine, vanillic aldehyde, Geniposide, diisopropylcarbodiimide mixing, 100 DEG C are warming up to, with 100r/
The speed stirring 3h of min, is squeezed out, water cooling with double screw extruder, air-dried, pelletizing obtains master batch；Being warming up to 120 DEG C melts master batch
Melt, deaeration, primary filament is obtained by spinneret；Primary filament in 60 DEG C of water-bath is stretched, obtains suture line fiber；
S2, prepares coating solution：Hydroformylation starch, coating are added in 40 parts of water, stirred with the speed of 800r/min
20min obtains coating solution；
S3, coating braiding：Coating treatment is carried out to the suture line fiber obtained in S1 with the coating solution obtained in S2, is dried in the air
Dry, braiding, sterilizing obtains sustained-release antibacterial absorbable medical suture.
Embodiment 3
A kind of sustained-release antibacterial absorbable medical suture, raw material include by weight：85 parts of carboxymethyl chitosan, red porgy
14 parts of fish skin collagen, 9 parts of grass carp ossein, 17 parts of pig bone collagen, 1.5 parts of mannitol, 2.5 parts of epoxidized soybean oil, glycerine 1.5
Part, 2.8 parts of vanillic aldehyde, 1.3 parts of Geniposide, 3.5 parts of diisopropylcarbodiimide, 0.6 part of hydroformylation starch, 4 parts of coating；
Wherein, the preparation method of coating is：It is 1.5wt% that Allicin, Arlacel-80, Tween-60 are added in mass fraction
In carboxymethyl chitosan sugar aqueous solution, 58 DEG C are warming up to, 80s is stirred with the speed of 9300r/min, obtains lotion, wherein, garlic is new
Element, Arlacel-80, the weight ratio of Tween-60 are 1.2：0.2：0.16, the weighing body of Allicin and carboxymethyl chitosan sugar aqueous solution
Product (g/ml) is than being 1.7：45；13 DEG C are adjusted the temperature to, lotion and mass fraction are distinguished for 1.5wt% sodium alginate aqueous solutions
It is added dropwise in water with the speed of 1.8ml/min, is stirred during dropwise addition with the speed of 750r/min simultaneously, continue to stir 28min,
22 DEG C are warming up to, adds in the hydroformylation amidin that mass fraction is 4wt%, is obtained with the speed stirring 35min of 750r/min
Solution A adjusts the pH=6.2 of solution A with sodium hydroxide solution, stirs 25min with the speed of 850r/min, is warming up to 57 DEG C,
Continuing to stir 45min, be cooled to 28 DEG C, standing filters to obtain filter cake, is warming up to 43 DEG C, and drying crosses 325 mesh sieves and obtains coating,
In, carboxymethyl chitosan solution, sodium alginate soln, water, the volume ratio of hydroformylation starch solution are 45：110：105：38.
The preparation method of above-mentioned sustained-release antibacterial absorbable medical suture, includes the following steps：
S1, suture line fiber is prepared：By carboxymethyl chitosan, red porgy fish skin collagen, grass carp ossein, pig bone collagen, sweet
Reveal alcohol, epoxidized soybean oil, glycerine, vanillic aldehyde, Geniposide, diisopropylcarbodiimide mixing, 92 DEG C are warming up to, with 250r/min
Speed stirring 2.2h, squeezed out with double screw extruder, water cooling, air-dry, pelletizing obtains master batch；Being warming up to 135 DEG C melts master batch
Melt, deaeration, primary filament is obtained by spinneret；Primary filament in 45 DEG C of water-bath is stretched, obtains suture line fiber；
S2, prepares coating solution：Hydroformylation starch, coating are added in 48 parts of water, stirred with the speed of 650r/min
27min obtains coating solution；
S3, coating braiding：Coating treatment is carried out to the suture line fiber obtained in S1 with the coating solution obtained in S2, is dried in the air
Dry, braiding, sterilizing obtains sustained-release antibacterial absorbable medical suture.
Embodiment 4
A kind of sustained-release antibacterial absorbable medical suture, raw material include by weight：95 parts of carboxymethyl chitosan, red porgy
12 parts of fish skin collagen, 11 parts of grass carp ossein, 13 parts of pig bone collagen, 2.5 parts of mannitol, 1.5 parts of epoxidized soybean oil, glycerine 2.5
Part, 2.2 parts of vanillic aldehyde, 1.7 parts of Geniposide, 2.5 parts of diisopropylcarbodiimide, 0.8 part of hydroformylation starch, 2 parts of coating；
Wherein, the preparation method of coating is：It is 2.5wt% that Allicin, Arlacel-80, Tween-60 are added in mass fraction
In carboxymethyl chitosan sugar aqueous solution, 52 DEG C are warming up to, 60s is stirred with the speed of 9700r/min, obtains lotion, wherein, garlic is new
Element, Arlacel-80, the weight ratio of Tween-60 are 1.8：0.16：0.2, the weighing body of Allicin and carboxymethyl chitosan sugar aqueous solution
Product (g/ml) is than being 1.3：55；11 DEG C are adjusted the temperature to, lotion and mass fraction are distinguished for 2.5wt% sodium alginate aqueous solutions
It is added dropwise in water with the speed of 1.2ml/min, is stirred during dropwise addition with the speed of 850r/min simultaneously, continue to stir 22min,
28 DEG C are warming up to, adds in the hydroformylation amidin that mass fraction is 2wt%, is obtained with the speed stirring 25min of 850r/min
Solution A adjusts the pH=6.8 of solution A with sodium hydroxide solution, stirs 35min with the speed of 750r/min, is warming up to 53 DEG C,
Continuing to stir 55min, be cooled to 22 DEG C, standing filters to obtain filter cake, is warming up to 47 DEG C, and drying crosses 230 mesh sieves and obtains coating,
In, carboxymethyl chitosan solution, sodium alginate soln, water, the volume ratio of hydroformylation starch solution are 55：90：115：32.
The preparation method of above-mentioned sustained-release antibacterial absorbable medical suture, includes the following steps：
S1, suture line fiber is prepared：By carboxymethyl chitosan, red porgy fish skin collagen, grass carp ossein, pig bone collagen, sweet
Reveal alcohol, epoxidized soybean oil, glycerine, vanillic aldehyde, Geniposide, diisopropylcarbodiimide mixing, 98 DEG C are warming up to, with 150r/min
Speed stirring 2.8h, squeezed out with double screw extruder, water cooling, air-dry, pelletizing obtains master batch；Being warming up to 125 DEG C melts master batch
Melt, deaeration, primary filament is obtained by spinneret；Primary filament in 55 DEG C of water-bath is stretched, obtains suture line fiber；
S2, prepares coating solution：Hydroformylation starch, coating are added in 42 parts of water, stirred with the speed of 750r/min
23min obtains coating solution；
S3, coating braiding：Coating treatment is carried out to the suture line fiber obtained in S1 with the coating solution obtained in S2, is dried in the air
Dry, braiding, sterilizing obtains sustained-release antibacterial absorbable medical suture.
Embodiment 5
A kind of sustained-release antibacterial absorbable medical suture, raw material include by weight：90 parts of carboxymethyl chitosan, red porgy
13 parts of fish skin collagen, 10 parts of grass carp ossein, 15 parts of pig bone collagen, 2 parts of mannitol, 2 parts of epoxidized soybean oil, 2 parts of glycerine, vanilla
2.5 parts of aldehyde, 1.5 parts of Geniposide, 3 parts of diisopropylcarbodiimide, 0.7 part of hydroformylation starch, 3 parts of coating；
Wherein, the preparation method of coating is：It is 2wt% carboxylics that Allicin, Arlacel-80, Tween-60 are added in mass fraction
In methyl chitosan aqueous solution, 55 DEG C are warming up to, 70s is stirred with the speed of 9500r/min, obtains lotion, wherein, garlic is new
Element, Arlacel-80, the weight ratio of Tween-60 are 1.5：0.18：0.18, the weight of Allicin and carboxymethyl chitosan sugar aqueous solution
Volume (g/ml) is than being 1.5：50；12 DEG C are adjusted the temperature to, lotion and mass fraction are distinguished for 2wt% sodium alginate aqueous solutions
It is added dropwise in water with the speed of 1.5ml/min, is stirred during dropwise addition with the speed of 800r/min simultaneously, continue to stir 25min,
25 DEG C are warming up to, adds in the hydroformylation amidin that mass fraction is 3wt%, is obtained with the speed stirring 30min of 800r/min
Solution A adjusts the pH=6.5 of solution A with sodium hydroxide solution, stirs 30min with the speed of 800r/min, is warming up to 55 DEG C,
Continuing to stir 50min, be cooled to 25 DEG C, standing filters to obtain filter cake, is warming up to 45 DEG C, and drying crosses 270 mesh sieves and obtains coating,
In, carboxymethyl chitosan solution, sodium alginate soln, water, the volume ratio of hydroformylation starch solution are 50：100：110：35.
The preparation method of above-mentioned sustained-release antibacterial absorbable medical suture, includes the following steps：
S1, suture line fiber is prepared：By carboxymethyl chitosan, red porgy fish skin collagen, grass carp ossein, pig bone collagen, sweet
Reveal alcohol, epoxidized soybean oil, glycerine, vanillic aldehyde, Geniposide, diisopropylcarbodiimide mixing, 95 DEG C are warming up to, with 200r/min
Speed stirring 2.5h, squeezed out with double screw extruder, water cooling, air-dry, pelletizing obtains master batch；Being warming up to 130 DEG C melts master batch
Melt, deaeration, primary filament is obtained by spinneret；Primary filament in 50 DEG C of water-bath is stretched, obtains suture line fiber；
S2, prepares coating solution：Hydroformylation starch, coating are added in 45 parts of water, stirred with the speed of 700r/min
25min obtains coating solution；
S3, coating braiding：Coating treatment is carried out to the suture line fiber obtained in S1 with the coating solution obtained in S2, is dried in the air
Dry, braiding, sterilizing obtains sustained-release antibacterial absorbable medical suture.
It carries out antibacterial bandwidth respectively to embodiment 1-5 and Durability of antimicrobial effect is investigated, result such as following table：
As can be seen from the above table, antibiotic property of the present invention is strong, being capable of long acting antibiotic.
The foregoing is only a preferred embodiment of the present invention, but protection scope of the present invention be not limited thereto,
Any one skilled in the art in the technical scope disclosed by the present invention, technique according to the invention scheme and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (9)
1. a kind of sustained-release antibacterial absorbable medical suture, which is characterized in that its raw material includes by weight：Carboxymethyl chitosan
80-100 parts, 10-15 parts of red porgy fish skin collagen, 8-12 parts of grass carp ossein, 10-20 parts of pig bone collagen, 1-3 parts of mannitol, ring
1-3 parts of oxygen soybean oil, 1-3 parts of glycerine, 2-3 parts of vanillic aldehyde, 1-2 parts of Geniposide, 2-4 parts of diisopropylcarbodiimide, hydroformylation are formed sediment
0.5-1 parts of powder, 1-5 parts of coating；
Wherein, the preparation method of coating is：Allicin, Arlacel-80, Tween-60 are added in carboxymethyl chitosan solution, risen
For temperature to 50-60 DEG C, stirring obtains lotion；10-15 DEG C is adjusted the temperature to, by lotion and sodium alginate soln respectively with 1-2ml/
The speed of min is added dropwise in water simultaneously, is stirred continuously during being added dropwise, and is continued to stir 20-30min, is warming up to 20-30 DEG C, adds
Enter hydroformylation starch solution, stirring 20-40min obtains solution A, adjusts the pH=6-7 of solution A, stirs 20-40min, be warming up to
50-60 DEG C, 40-60min is stirred, is cooled to 20-30 DEG C, standing filters to obtain filter cake, is warming up to 40-50 DEG C, dry, sieving obtains
Coating.
2. according to the claim 1 sustained-release antibacterial absorbable medical suture, which is characterized in that the preparation method of coating
For：Allicin, Arlacel-80, Tween-60 are added in carboxymethyl chitosan solution, 50-60 DEG C is warming up to, with 9000-
The speed stirring 50-90s of 10000r/min, obtains lotion；10-15 DEG C is adjusted the temperature to, by lotion and sodium alginate soln point
It is not added dropwise to simultaneously in water with the speed of 1-2ml/min, is stirred during dropwise addition with the speed of 700-900r/min, continue to stir
20-30min is warming up to 20-30 DEG C, adds in hydroformylation starch solution, is obtained with the speed stirring 20-40min of 700-900r/min
Solution A adjusts the pH=6-7 of solution A with sodium hydroxide solution, and 20-40min, heating are stirred with the speed of 700-900r/min
To 50-60 DEG C, continue to stir 40-60min, be cooled to 20-30 DEG C, standing filters to obtain filter cake, is warming up to 40-50 DEG C, dry, mistake
200-400 mesh sieves obtain coating.
3. sustained-release antibacterial absorbable medical suture according to claim 1 or claim 2, which is characterized in that in the preparation side of coating
In method, carboxymethyl chitosan solution is that mass fraction is 1-3wt% carboxymethyl chitosan sugar aqueous solutions.
4. sustained-release antibacterial absorbable medical suture according to claim 1 or claim 2, which is characterized in that in the preparation side of coating
In method, Allicin, Arlacel-80, the weight ratio of Tween-60 are 1-2：0.12-0.24：0.12-0.24.
5. sustained-release antibacterial absorbable medical suture according to claim 1 or claim 2, which is characterized in that in the preparation side of coating
In method, the bulking value (g/ml) of Allicin and carboxymethyl chitosan solution is than being 1-2：40-60.
6. sustained-release antibacterial absorbable medical suture according to claim 1 or claim 2, which is characterized in that in the preparation side of coating
In method, sodium alginate soln is that mass fraction is 1-3wt% sodium alginate aqueous solutions.
7. sustained-release antibacterial absorbable medical suture according to claim 1 or claim 2, which is characterized in that in the preparation side of coating
In method, carboxymethyl chitosan solution, sodium alginate soln, water, the volume ratio of hydroformylation starch solution are 40-60：80-120：100-
120：30-40.
8. sustained-release antibacterial absorbable medical suture according to claim 1 or claim 2, which is characterized in that in the preparation side of coating
In method, hydroformylation starch solution is the hydroformylation amidin that mass fraction is 1-5wt%.
9. a kind of preparation method of the sustained-release antibacterial absorbable medical suture as described in claim any one of 1-8, feature exist
In including the following steps：
S1, suture line fiber is prepared：By carboxymethyl chitosan, red porgy fish skin collagen, grass carp ossein, pig bone collagen, mannitol,
Epoxidized soybean oil, glycerine, vanillic aldehyde, Geniposide, diisopropylcarbodiimide mixing, are warming up to 90-100 DEG C, with 100-300r/
The speed stirring 2-3h of min, is squeezed out, water cooling with double screw extruder, air-dried, pelletizing obtains master batch；Being warming up to 120-140 DEG C makes
Master batch melts, and deaeration obtains primary filament by spinneret；Primary filament in 40-60 DEG C of water-bath is stretched, is sutured
Line fiber；
S2, prepares coating solution：Hydroformylation starch, coating are added in 40-50 parts of water, stirred with the speed of 600-800r/min
20-30min obtains coating solution；
S3, coating braiding：Coating treatment is carried out to the suture line fiber obtained in S1 with the coating solution obtained in S2, is dried,
Braiding, sterilizing obtain sustained-release antibacterial absorbable medical suture.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510496155.3A CN105056294B (en) | 2015-08-11 | A kind of sustained-release antibacterial absorbable medical suture and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510496155.3A CN105056294B (en) | 2015-08-11 | A kind of sustained-release antibacterial absorbable medical suture and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105056294A CN105056294A (en) | 2015-11-18 |
| CN105056294B true CN105056294B (en) | 2018-06-01 |
Family
ID=
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1546557A (en) * | 2003-12-02 | 2004-11-17 | 武汉大学 | Preparation method and uses of carboxymethyl chitosan and sodium alginate blend microcapsule |
| CN103540203A (en) * | 2012-07-13 | 2014-01-29 | 上海立昌环境工程有限公司 | Degradable multifunctional protective film |
| CN104368039A (en) * | 2014-11-25 | 2015-02-25 | 苏州市贝克生物科技有限公司 | Medical absorbable suture line and preparation method thereof |
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1546557A (en) * | 2003-12-02 | 2004-11-17 | 武汉大学 | Preparation method and uses of carboxymethyl chitosan and sodium alginate blend microcapsule |
| CN103540203A (en) * | 2012-07-13 | 2014-01-29 | 上海立昌环境工程有限公司 | Degradable multifunctional protective film |
| CN104368039A (en) * | 2014-11-25 | 2015-02-25 | 苏州市贝克生物科技有限公司 | Medical absorbable suture line and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| "pH-sensitive interpenetrating network hydrogels based on chitosan derivatives and alginate for oral drug delivery";Ji Yang等;《Carbohydrate Polymers》;20120929;第92卷(第1期);719-725 * |
| "胶原/壳聚糖止血敷料在外科伤口中的应用";高文彪等;《中国组织工程研究》;20120715;第16卷(第29期);5477-5480 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105079870B (en) | A kind of long acting antibiotic absorbable medical suture | |
| CN105107016B (en) | A kind of high antibiotic property absorbable medical suture | |
| RU2621114C2 (en) | Polysaccharide fibers for wound dressings | |
| CN101905034B (en) | Method for preparing biological polysaccharide self-assembly modificatory chitosan antibacterial biological material | |
| CN101703794B (en) | Controlled degradable surgical suture thread and fabricating method thereof | |
| CN105536055B (en) | A kind of shape memory type high resiliency active nano fibrous framework and its application | |
| CN109646710A (en) | A kind of hemostatic material and preparation method thereof of clinical department of internal medicine hemostasis | |
| CN105477674A (en) | Hemostasis composite material based on chitosan and marine mussel mucin and preparation method of hemostasis composite material | |
| CN114344556A (en) | Polyphenol-silk fibroin-polyethylene glycol medical tissue adhesive, preparation method and application | |
| CN105056295B (en) | A kind of anti-inflammatory, antibacterial absorbable medical suture and preparation method thereof | |
| CN112587715A (en) | Preparation method of high-adhesion medical composite adhesive | |
| CN107296978A (en) | A kind of spongy hemostatic material in medical use of organism | |
| CN201533923U (en) | Controllably degraded surgery suture | |
| CN109498833A (en) | A kind of Medical absorbable polysaccharide composite material and application thereof | |
| CN108187125A (en) | A kind of konjaku glucomannan operation suture thread and preparation method thereof | |
| CN107519527A (en) | A kind of medical absorbable suture with antibiotic property and preparation method thereof | |
| CN105056294B (en) | A kind of sustained-release antibacterial absorbable medical suture and preparation method thereof | |
| CN105079868B (en) | A kind of good absorbable medical suture of compatibility and preparation method thereof | |
| CN107376005A (en) | A kind of biodegradable medical hemostatic paper and preparation method thereof | |
| CN105088465A (en) | Absorbable surgical suture line resistant to degradation and good in compatibility and preparing method of absorbable surgical suture line resistant to degradation and good in compatibility | |
| CN114773629B (en) | Preparation method of injectable photo-curing hemostatic hydrogel for traumatic brain injury | |
| CN108853563A (en) | A kind of preparation method of absorbable suture | |
| CN105056294A (en) | Slow-release, antibacterial and absorbable medical suture and preparation method thereof | |
| CN107715167A (en) | Chitosan-based hemostatic paste and preparation method as bone wax substitute | |
| JPS5827813B2 (en) | Natural protein polymer hydrogel |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: The invention relates to a sustained-release antibacterial absorbable medical suture and a preparation method thereof Effective date of registration: 20210112 Granted publication date: 20180601 Pledgee: Tianchang Science and Technology Financing Guarantee Co.,Ltd. Pledgor: ANHUI KANGNING MEDICAL PRODUCTS Co.,Ltd. Registration number: Y2021980000270 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20220126 Granted publication date: 20180601 Pledgee: Tianchang Science and Technology Financing Guarantee Co.,Ltd. Pledgor: ANHUI KANGNING MEDICAL PRODUCTS CO.,LTD. Registration number: Y2021980000270 |