A kind of good absorbable medical suture of compatibility and preparation method thereof
Technical field
The present invention relates to suture technical field more particularly to a kind of good absorbable medical suture of compatibility and its
Preparation method.
Background technology
Operation suture thread refers to one kind for wound ligation, Suture hemostasis and tissue suture in surgical operation
It is special to use line.It can be divided into two classes according to its biodegradability:Nonabsorable line and absorbable thread.Absorbable thread suture includes
Natural fiber and synthesis high score subclass suture.
Synthesis macromolecule suture includes polyglycolide (PGA) class suture, polylactic acid (PLA) class suture, gathers to two
Oxygen cyclohexanone (PDS) suture etc..Absorbable suture degradation in vivo absorbs, and avoids the pain that second operation is brought to patient
Hardship, and can be according to actual operation needs, the different suture of selection degradation time.
PGA fibers are well suited for the adherency and breeding of cell, but due to its faster degradation speed, cannot organize the formation of
It is preceding that enough strengths are provided;Compared with PGA fibers, the degradation rate of PLA fibers is slower, but PLA has hydrophobicity, and cell is not
Preferably it can adhere to and breed on fiber, when using suture made of this kind of polymer, it is difficult to meet degradation speed simultaneously
Rate is slow and cell easily adheres to, breeds the two conditions.
Invention content
Technical problems based on background technology, the present invention propose a kind of good absorbable medical suture of compatibility and
Preparation method, the present invention is good with biological tissue compatibility, adheres to and breeds, good mechanical property in the present invention conducive to cell,
Degradation resistant, it is easy to operate, it is conducive to industrialized production.
The good absorbable medical suture of a kind of compatibility proposed by the present invention, raw material include by weight:Polyglycolide
20-40 parts, 10-20 parts of polydactyl acid, 50-70 parts of polylactic acid, 10-20 parts of hyaluronic acid, 5-7 parts of methyl methacrylate,
4-6 parts of epoxidized soybean oil, 2-4 parts of tea oil, 1-5 parts of polycaprolactone, 0.1-0.3 parts of calcium stearate, 15-30 parts of ethyl alcohol.
Preferably, the preparation method of polydactyl acid is as follows:Polylactic acid is added in the first organic solvent and is dissolved, is passed through lazy
Property gas, be added 2- ethylhexyl methacrylic anhydrides, heat up, keep the temperature, purification, obtain intermediate material;Grass is added in itaconic acid
It in acyl chlorides, heats up, keeps the temperature, purification obtains itaconic anhydride;Intermediate material is added in third organic solvent and is dissolved, clothing health is added
Acid anhydrides, auxiliary agent are passed through inert gas, heat up, and keep the temperature, and purification obtains polydactyl acid.
Preferably, the preparation method of polydactyl acid is as follows:Polylactic acid is added in the first organic solvent and is dissolved, is passed through lazy
Property gas, be added 2- ethylhexyl methacrylic anhydrides, heat up, heat preservation, be added dropwise in the first precipitating reagent, filter, be dried to obtain
Intermediate material;Itaconic acid is added in oxalyl chloride, is heated up, is kept the temperature, is filtered, filter cake is added in the second organic solvent and is impregnated, is taken out
Filter, is dried to obtain itaconic anhydride;Intermediate material is added in third organic solvent and is dissolved, itaconic anhydride, auxiliary agent is added, is passed through lazy
Property gas, heat up, heat preservation, be added dropwise in the second precipitating reagent, filter, be dried to obtain polydactyl acid.
Preferably, in the preparation method of polydactyl acid, the first organic solvent is chloroform.
Preferably, in the preparation method of polydactyl acid, the first precipitating reagent is ethyl alcohol.
Preferably, in the preparation method of polydactyl acid, the second organic solvent is the one or both in ether, petroleum ether
The mixed solvent of composition.
Preferably, in the preparation method of polydactyl acid, the second organic solvent is that the mixing that ether and petroleum ether form is molten
Agent, wherein the volume ratio of ether and petroleum ether is 0.8-1.2:0.8-1.2.
Preferably, in the preparation method of polydactyl acid, third organic solvent is toluene.
Preferably, in the preparation method of polydactyl acid, the second precipitating reagent is n-hexane.
Preferably, in the preparation method of polydactyl acid, inert gas is nitrogen.
Preferably, in the preparation method of polydactyl acid, auxiliary agent is azodiisobutyronitrile.
Preferably, in the preparation method of polydactyl acid, polylactic acid, the first organic solvent, 2- ethylhexyl metering systems
Acid anhydrides, the first precipitating reagent weight ratio be 2-4:10-20:6-13:100-150.
Preferably, in the preparation method of polydactyl acid, itaconic acid, oxalyl chloride, the second organic solvent weight ratio be 7-
11:30-40:40-60.
Preferably, in the preparation method of polydactyl acid, intermediate material, third organic solvent, itaconic anhydride, auxiliary agent,
The weight ratio of two precipitating reagents is 10-15:10-20:1-1.5:0.03-0.05:100-120.
Preferably, the preparation method of polydactyl acid is as follows:Polylactic acid is added in the first organic solvent and is dissolved, is passed through lazy
Property gas, 2- ethylhexyl methacrylic anhydrides are added, are warming up to 50-70 DEG C, keep the temperature 2-4h, it is cooling, be added dropwise to the first precipitation
It in agent, filters, is warming up to 40-60 DEG C, vacuum drying 10-15h obtains intermediate material;Itaconic acid is added in oxalyl chloride, heating
To 90-110 DEG C, 2-3h is kept the temperature, is filtered, filter cake is added in the second organic solvent and impregnates 18-22h, filters, is warming up to 30-40
DEG C, vacuum drying 36-48h obtains itaconic anhydride;Intermediate material is added in third organic solvent and is dissolved, addition itaconic anhydride,
Auxiliary agent is passed through inert gas, is warming up to 60-80 DEG C, and 10-15h is stirred with the speed of 80-120r/min, cooling, is added dropwise to second
It in precipitating reagent, filters, is warming up to 40-50 DEG C, vacuum drying 36-48h obtains polydactyl acid.
Preferably, raw material includes by weight:25-35 parts of polyglycolide, 12-18 parts of polydactyl acid, polylactic acid 55-
65 parts, 13-17 parts of hyaluronic acid, 5.5-6.5 parts of methyl methacrylate, 4.5-5.5 parts of epoxidized soybean oil, tea oil 2.5-
3.5 parts, 2-4 parts of polycaprolactone, 0.15-0.25 parts of calcium stearate.
The invention also provides the preparation methods of the good absorbable medical suture of above-mentioned compatibility, include the following steps:
S1, suture line fiber is prepared:By polyglycolide, polydactyl acid, polylactic acid, hyaluronic acid, methyl methacrylate
Ester, epoxidized soybean oil, tea oil mixing, are warming up to 60-80 DEG C, stir 4-6h with the speed of 200-300r/min, are warming up to
It 100-120 DEG C, is squeezed out, water cooling, is air-dried, pelletizing obtains master batch with double screw extruder;Being warming up to 150-170 DEG C keeps master batch molten
Melt, deaeration, primary filament is obtained by spinneret;Primary filament is stretched in 40-60 DEG C of water-bath, obtains suture fibre
Dimension;
S2, prepares coating solution:Polycaprolactone is added in ethyl alcohol after stirring, calcium stearate powder stirring is added, rises
Temperature obtains coating solution to 40-50 DEG C;
S3, coating braiding:Coating treatment is carried out to the suture line fiber obtained in S1 with the coating solution obtained in S2, is dried in the air
Dry, braiding, sterilizing obtains the good absorbable medical suture of compatibility.
Preferably, in S2, polycaprolactone is added in ethyl alcohol, 4-6h is stirred with the speed of 100-300r/min, is added
Calcium stearate powder stirs 4-6h with the speed of 100-300r/min, is warming up to 40-50 DEG C and obtains coating solution, wherein is stearic
Sour calcium grain diameter is 1-5 μm.
" spinneret " in above-mentioned S1 has different apertures, and specification should be needed to select corresponding aperture according to production.
The present invention selects 2- ethylhexyls methacrylic anhydride and polylactic acid to be obtained by the reaction and introduced in polylactic acid
Carbon-carbon double bond issues raw radical reaction in the initiation of azodiisobutyronitrile with the itaconic anhydride with carbon-carbon double bond, increases
The molecular weight for having added polydactyl acid, obtains the polydactyl acid containing a large amount of anhydride groups, and acid anhydrides facile hydrolysis is at carboxyl, from big
The big hydrophily and cellular affinity for improving polylactic acid, increases the cell compatibility of the present invention;With polylactic acid, polyglycolide and
Polydactyl acid is blended, polylactic acid, polydactyl acid, can increase the degradation resistance energy and mechanical performance of the present invention;Poly- second is handed over
Ester and polydactyl acid can make cell is easier to adhere to and breed in the present invention, shorten wound healing time;Hyalomitome
Acid can repair scar, promote wound healing;Methyl methacrylate can promote polylactic acid, polyglycolide and polydactyl acid
Copolymerization, increase the present invention mechanical strength;Epoxidized soybean oil can increase the stability of the present invention;Tea oil can increase the present invention
Antibacterial, bactericidal properties;Braiding structure is close, not will produce sub-wire phenomenon, further increases the mechanical performance and resistance to of the present invention
Degradation property;Have coating on suture line fiber, bacterium can be prevented to be concealed in weaving hole, increases the antibacterial of the present invention
Property;Coating can increase the slickness of the present invention, reduce tissue drag force, reduce the pain brought to patient when suture;The present invention
It is easy to operate, it is conducive to industrial production.
Description of the drawings
Fig. 1 is a kind of process flow chart of the preparation method of the good absorbable medical suture of compatibility proposed by the present invention.
Specific implementation mode
As shown in FIG. 1, FIG. 1 is a kind of works of the preparation method of the good absorbable medical suture of compatibility proposed by the present invention
Skill flow chart.
Referring to Fig.1, the preparation method of the good absorbable medical suture of a kind of compatibility proposed by the present invention, including walk as follows
Suddenly:
S1, suture line fiber is prepared:By polyglycolide, polydactyl acid, polylactic acid, hyaluronic acid, methyl methacrylate
Ester, epoxidized soybean oil, tea oil mixing, are warming up to 60-80 DEG C, stir 4-6h with the speed of 200-300r/min, are warming up to
It 100-120 DEG C, is squeezed out, water cooling, is air-dried, pelletizing obtains master batch with double screw extruder;Being warming up to 150-170 DEG C keeps master batch molten
Melt, deaeration, primary filament is obtained by spinneret;Primary filament is stretched in 40-60 DEG C of water-bath, obtains suture fibre
Dimension;
S2, prepares coating solution:Polycaprolactone is added in ethyl alcohol after stirring, calcium stearate powder stirring is added, rises
Temperature obtains coating solution to 40-50 DEG C;
S3, coating braiding:Coating treatment is carried out to the suture line fiber obtained in S1 with the coating solution obtained in S2, is dried in the air
Dry, braiding, sterilizing obtains the good absorbable medical suture of compatibility.
In the following, technical scheme of the present invention is described in detail by specific embodiment.
Embodiment 1
A kind of good absorbable medical suture of compatibility, raw material include by weight:40 parts of polyglycolide, modified poly- breast
10 parts of acid, 70 parts of polylactic acid, 10 parts of hyaluronic acid, 7 parts of methyl methacrylate, 4 parts of epoxidized soybean oil, 4 parts of tea oil gather oneself
1 part of lactone, 0.3 part of calcium stearate, 15 parts of ethyl alcohol;
Wherein, the preparation method of polydactyl acid is as follows:2 parts of polylactic acid are added by weight molten in 20 parts of chloroforms
Solution is passed through nitrogen, and 6 parts of 2- ethylhexyl methacrylic anhydrides are added, and is warming up to 70 DEG C, keeps the temperature 2h, cooling, is added dropwise to 150 parts
It in ethyl alcohol, filters, is warming up to 40 DEG C, vacuum drying 15h obtains intermediate material;40 parts of grass are added in 7 parts of itaconic acids by weight
In acyl chlorides, 90 DEG C are warming up to, keeps the temperature 3h, is filtered, filter cake is added in 40 parts of ether and impregnates 22h, filters, is warming up to 30 DEG C, very
The dry 48h of sky obtains itaconic anhydride;10 parts of intermediate materials are added in 20 parts of toluene by weight and are dissolved, 1 part of itaconic acid is added
Acid anhydride, 0.05 part of azodiisobutyronitrile, are passed through nitrogen, are warming up to 60 DEG C, and 10h is stirred with the speed of 120r/min, cooling, are added dropwise to
It in 120 parts of n-hexanes, filters, is warming up to 40 DEG C, vacuum drying 48h obtains polydactyl acid.
The preparation method of the good absorbable medical suture of above-mentioned compatibility, includes the following steps:
S1, suture line fiber is prepared:By polyglycolide, polydactyl acid, polylactic acid, hyaluronic acid, methyl methacrylate
Ester, epoxidized soybean oil, tea oil mixing, are warming up to 60 DEG C, stir 4h with the speed of 300r/min, 120 DEG C are warming up to, with double spiral shells
Bar extruder squeezes out, water cooling, air-dries, pelletizing obtains master batch;Being warming up to 150 DEG C makes master batch melt, and deaeration is obtained by spinneret
Primary filament;Primary filament is stretched in 60 DEG C of water-bath, obtains suture line fiber;
S2, prepares coating solution:Polycaprolactone is added in ethyl alcohol, 4h is stirred with the speed of 300r/min, is added hard
Resin acid calcium powder stirs 4h with the speed of 300r/min, is warming up to 50 DEG C and obtains coating solution, wherein calcium stearate grain size is 1
μm;
S3, coating braiding:Coating treatment is carried out to the suture line fiber obtained in S1 with the coating solution obtained in S2, is dried in the air
Dry, braiding, sterilizing obtains the good absorbable medical suture of compatibility.
Embodiment 2
A kind of good absorbable medical suture of compatibility, raw material include by weight:20 parts of polyglycolide, modified poly- breast
20 parts of acid, 50 parts of polylactic acid, 20 parts of hyaluronic acid, 5 parts of methyl methacrylate, 6 parts of epoxidized soybean oil, 2 parts of tea oil gather oneself
5 parts of lactone, 0.1 part of calcium stearate, 30 parts of ethyl alcohol;
Wherein, the preparation method of polydactyl acid is as follows:4 parts of polylactic acid are added by weight molten in 10 parts of chloroforms
Solution is passed through nitrogen, and 13 parts of 2- ethylhexyl methacrylic anhydrides are added, and is warming up to 50 DEG C, keeps the temperature 4h, cooling, is added dropwise to 100 parts
It in ethyl alcohol, filters, is warming up to 60 DEG C, vacuum drying 10h obtains intermediate material;30 parts of grass are added in 11 parts of itaconic acids by weight
In acyl chlorides, 110 DEG C are warming up to, keeps the temperature 2h, is filtered, filter cake is added in 60 parts of petroleum ethers and impregnates 18h, filters, is warming up to 40 DEG C,
Vacuum drying 36h obtains itaconic anhydride;15 parts of intermediate materials are added in 10 parts of toluene by weight and are dissolved, 1.5 parts of clothing are added
Health acid anhydrides, 0.03 part of azodiisobutyronitrile, are passed through nitrogen, are warming up to 80 DEG C, stir 15h with the speed of 80r/min, cooling, drop
It adds in 100 parts of n-hexanes, filters, be warming up to 50 DEG C, vacuum drying 36h obtains polydactyl acid.
The preparation method of the good absorbable medical suture of above-mentioned compatibility, includes the following steps:
S1, suture line fiber is prepared:By polyglycolide, polydactyl acid, polylactic acid, hyaluronic acid, methyl methacrylate
Ester, epoxidized soybean oil, tea oil mixing, are warming up to 80 DEG C, stir 6h with the speed of 200r/min, 100 DEG C are warming up to, with double spiral shells
Bar extruder squeezes out, water cooling, air-dries, pelletizing obtains master batch;Being warming up to 170 DEG C makes master batch melt, and deaeration is obtained by spinneret
Primary filament;Primary filament is stretched in 40 DEG C of water-bath, obtains suture line fiber;
S2, prepares coating solution:Polycaprolactone is added in ethyl alcohol, 6h is stirred with the speed of 100r/min, is added hard
Resin acid calcium powder stirs 6h with the speed of 100r/min, is warming up to 40 DEG C and obtains coating solution, wherein calcium stearate grain size is 5
μm;
S3, coating braiding:Coating treatment is carried out to the suture line fiber obtained in S1 with the coating solution obtained in S2, is dried in the air
Dry, braiding, sterilizing obtains the good absorbable medical suture of compatibility.
Embodiment 3
A kind of good absorbable medical suture of compatibility, raw material include by weight:25 parts of polyglycolide, modified poly- breast
18 parts of acid, 55 parts of polylactic acid, 17 parts of hyaluronic acid, 5.5 parts of methyl methacrylate, 5.5 parts of epoxidized soybean oil, tea oil 2.5
Part, 4 parts of polycaprolactone, 0.15 part of calcium stearate, 25 parts of ethyl alcohol;
Wherein, the preparation method of polydactyl acid is as follows:3.5 parts of polylactic acid are added in 12 parts of chloroforms by weight
Dissolving is passed through nitrogen, and 11 parts of 2- ethylhexyl methacrylic anhydrides are added, and is warming up to 55 DEG C, keeps the temperature 3.5h, cooling, is added dropwise to
It in 120 parts of ethyl alcohol, filters, is warming up to 55 DEG C, vacuum drying 11h obtains intermediate material;10 parts of itaconic acids are added by weight
In 33 parts of oxalyl chlorides, 105 DEG C are warming up to, keeps the temperature 2.3h, is filtered, 55 parts of in the mixed solvents, which are added, in filter cake impregnates 19h, filters,
38 DEG C are warming up to, vacuum drying 40h obtains itaconic anhydride, wherein mixed solvent is made of ether and petroleum ether, ether and oil
The volume ratio of ether is 1.2:0.8;14 parts of intermediate materials are added in 12 parts of toluene by weight and are dissolved, 1.3 parts of itaconic acids are added
Acid anhydride, 0.035 part of azodiisobutyronitrile, are passed through nitrogen, are warming up to 75 DEG C, and 14h is stirred with the speed of 90r/min, cooling, are added dropwise to
It in 105 parts of n-hexanes, filters, is warming up to 47 DEG C, vacuum drying 40h obtains polydactyl acid.
The preparation method of the good absorbable medical suture of above-mentioned compatibility, includes the following steps:
S1, suture line fiber is prepared:By polyglycolide, polydactyl acid, polylactic acid, hyaluronic acid, methyl methacrylate
Ester, epoxidized soybean oil, tea oil mixing, are warming up to 75 DEG C, stir 5.5h with the speed of 220r/min, are warming up to 105 DEG C, with double
Screw extruder squeezes out, water cooling, air-dries, pelletizing obtains master batch;Being warming up to 165 DEG C makes master batch melt, and deaeration is obtained by spinneret
To primary filament;Primary filament is stretched in 45 DEG C of water-bath, obtains suture line fiber;
S2, prepares coating solution:Polycaprolactone is added in ethyl alcohol, 5.5h is stirred with the speed of 130r/min, is added
Calcium stearate powder stirs 5.5h with the speed of 130r/min, is warming up to 43 DEG C and obtains coating solution, wherein stearic acid calcium grain
Diameter is 4 μm;
S3, coating braiding:Coating treatment is carried out to the suture line fiber obtained in S1 with the coating solution obtained in S2, is dried in the air
Dry, braiding, sterilizing obtains the good absorbable medical suture of compatibility.
Embodiment 4
A kind of good absorbable medical suture of compatibility, raw material include by weight:Poly- second hands over 35 parts, polydactyl acid
12 parts, 65 parts of polylactic acid, 13 parts of hyaluronic acid, 6.5 parts of methyl methacrylate, 4.5 parts of epoxidized soybean oil, 3.5 parts of tea oil,
2 parts of polycaprolactone, 0.25 part of calcium stearate, 20 parts of ethyl alcohol;
Wherein, the preparation method of polydactyl acid is as follows:2.5 parts of polylactic acid are added in 18 parts of chloroforms by weight
Dissolving is passed through nitrogen, and 8 parts of 2- ethylhexyl methacrylic anhydrides are added, and is warming up to 65 DEG C, keeps the temperature 2.5h, cooling, is added dropwise to
It in 140 parts of ethyl alcohol, filters, is warming up to 45 DEG C, vacuum drying 13h obtains intermediate material;8 parts of itaconic acids are added 37 by weight
In part oxalyl chloride, 95 DEG C are warming up to, keeps the temperature 2.7h, is filtered, 45 parts of in the mixed solvents, which are added, in filter cake impregnates 21h, suction filtration, heating
To 32 DEG C, vacuum drying 44h obtains itaconic anhydride, wherein mixed solvent is made of ether and petroleum ether, ether and petroleum ether
Volume ratio is 0.8:1.2;12 parts of intermediate materials are added in 18 parts of toluene by weight and are dissolved, 1.1 parts of itaconic anhydrides of addition,
0.045 part of azodiisobutyronitrile, is passed through nitrogen, is warming up to 65 DEG C, and 12h is stirred with the speed of 110r/min, cooling, is added dropwise to
It in 115 parts of n-hexanes, filters, is warming up to 43 DEG C, vacuum drying 44h obtains polydactyl acid.
The preparation method of the good absorbable medical suture of above-mentioned compatibility, includes the following steps:
S1, suture line fiber is prepared:By polyglycolide, polydactyl acid, polylactic acid, hyaluronic acid, methyl methacrylate
Ester, epoxidized soybean oil, tea oil mixing, are warming up to 65 DEG C, stir 4.5h with the speed of 280r/min, are warming up to 115 DEG C, with double
Screw extruder squeezes out, water cooling, air-dries, pelletizing obtains master batch;Being warming up to 155 DEG C makes master batch melt, and deaeration is obtained by spinneret
To primary filament;Primary filament is stretched in 55 DEG C of water-bath, obtains suture line fiber;
S2, prepares coating solution:Polycaprolactone is added in ethyl alcohol, 4.5h is stirred with the speed of 170r/min, is added
Calcium stearate powder stirs 4.5h with the speed of 170r/min, is warming up to 47 DEG C and obtains coating solution, wherein stearic acid calcium grain
Diameter is 2 μm;
S3, coating braiding:Coating treatment is carried out to the suture line fiber obtained in S1 with the coating solution obtained in S2, is dried in the air
Dry, braiding, sterilizing obtains the good absorbable medical suture of compatibility.
Embodiment 5
A kind of good absorbable medical suture of compatibility, raw material include by weight:30 parts of polyglycolide, modified poly- breast
15 parts of acid, 60 parts of polylactic acid, 15 parts of hyaluronic acid, 6 parts of methyl methacrylate, 5 parts of epoxidized soybean oil, 3 parts of tea oil gather oneself
3 parts of lactone, 0.2 part of calcium stearate, 23 parts of ethyl alcohol;
Wherein, the preparation method of polydactyl acid is as follows:3 parts of polylactic acid are added by weight molten in 15 parts of chloroforms
Solution is passed through nitrogen, and 10 parts of 2- ethylhexyl methacrylic anhydrides are added, and is warming up to 60 DEG C, keeps the temperature 3h, cooling, is added dropwise to 130 parts
It in ethyl alcohol, filters, is warming up to 50 DEG C, vacuum drying 12h obtains intermediate material;35 parts of grass are added in 9 parts of itaconic acids by weight
In acyl chlorides, 100 DEG C are warming up to, keeps the temperature 2.5h, is filtered, 50 parts of in the mixed solvents, which are added, in filter cake impregnates 20h, filters, is warming up to
35 DEG C, vacuum drying 42h obtains itaconic anhydride, wherein mixed solvent is made of ether and petroleum ether, the body of ether and petroleum ether
Product is than being 1:1;13 parts of intermediate materials are added in 15 parts of toluene by weight and are dissolved, 1.2 parts of itaconic anhydrides, 0.04 part of idol is added
Nitrogen bis-isobutyronitrile, is passed through nitrogen, is warming up to 70 DEG C, and 13h is stirred with the speed of 100r/min, cooling, is added dropwise to 110 parts of n-hexanes
In, it filters, is warming up to 45 DEG C, vacuum drying 42h obtains polydactyl acid.
The preparation method of the good absorbable medical suture of above-mentioned compatibility, includes the following steps:
S1, suture line fiber is prepared:By polyglycolide, polydactyl acid, polylactic acid, hyaluronic acid, methyl methacrylate
Ester, epoxidized soybean oil, tea oil mixing, are warming up to 70 DEG C, stir 5h with the speed of 250r/min, 110 DEG C are warming up to, with double spiral shells
Bar extruder squeezes out, water cooling, air-dries, pelletizing obtains master batch;Being warming up to 160 DEG C makes master batch melt, and deaeration is obtained by spinneret
Primary filament;Primary filament is stretched in 50 DEG C of water-bath, obtains suture line fiber;
S2, prepares coating solution:Polycaprolactone is added in ethyl alcohol, 5h is stirred with the speed of 200r/min, is added hard
Resin acid calcium powder stirs 5h with the speed of 200r/min, is warming up to 45 DEG C and obtains coating solution, wherein calcium stearate grain size is 3
μm;
S3, coating braiding:Coating treatment is carried out to the suture line fiber obtained in S1 with the coating solution obtained in S2, is dried in the air
Dry, braiding, sterilizing obtains the good absorbable medical suture of compatibility.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Any one skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.