CN105056173A - Chinese herbal medicament for treating gastroesophageal reflux disease with intermingled cold and heat symptom - Google Patents
Chinese herbal medicament for treating gastroesophageal reflux disease with intermingled cold and heat symptom Download PDFInfo
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- CN105056173A CN105056173A CN201510462287.4A CN201510462287A CN105056173A CN 105056173 A CN105056173 A CN 105056173A CN 201510462287 A CN201510462287 A CN 201510462287A CN 105056173 A CN105056173 A CN 105056173A
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Abstract
The invention belongs to the technical field of medicaments and particularly relates to a Chinese herbal medicament for treating gastroesophageal reflux disease with the intermingled cold and heat symptom. The Chinese herbal medicament comprises, in parts by weight, 5 to 13 parts of Pinellia tuber, 8 to 16 parts of dried ginger, 8 to 16 parts of rhizome of Chinese goldthread, 8 to 16 parts of baical skullcap root, 5 to 13 parts of glaucescent swallowwort rhizome, 5 to 13 parts of common hogfenneI root, 5 to 13 parts of officinal magnolia bark, 5 to 13 parts of areca peel, 5 to 13 parts of cuttlefish bone, 8 to 16 parts of calcined ark shell, 5 to 13 parts of Perilla seed, 8 to 16 parts of hemp seed, and 4 to 8 parts of licorice root. The Chinese herbal medicament is effective in evidently improving symptoms and improving life quality of a patient and has good clinical treatment effect.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of Chinese medicine for the treatment of intermingling cold and heat gastroesophageal reflux disease.
Background technology
Gastroesophageal reflux disease refers to due to the various cause of disease cause stomach or duodenum content reflux to enter symptom that esophagus causes or histologic lesion, and its main manifestations is causalgia etc. after heartburn, acid regurgitation, breastbone, and the touching difficulty of its state of an illness more.Epidemiological study shows, the intermingling cold and heat gastroesophageal reflux disease sickness rate that the area such as Beijing, Shanghai is appointed is 10%, but along with the development of society, the quickening of rhythm of life, the change etc. of dietary structure, sickness rate is in rising trend, greatly have impact on the quality of life of patient.Proton pump inhibitor is the best medicine of current western medical treatment gastroesophageal reflux disease, although obtain good curative effect, long, the easily recurrence course for the treatment of, some patients can not tolerate its treatment or insensitive to it be the difficult problem on puzzlement digestion circle.Therefore, the evaluation of clinical curative effect of carrying out Chinese medicine is significant.
Summary of the invention
Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, a kind of Chinese medicine for the treatment of intermingling cold and heat gastroesophageal reflux disease is provided, this Chinese medicine obviously can improve symptom, improves patients ' life quality, achieves good clinical efficacy.
The present invention is achieved through the following technical solutions:
Treat a Chinese medicine for intermingling cold and heat gastroesophageal reflux disease, be made up of the Chinese medicine of following weight portion:
Rhizoma Pinelliae 5-13 part, Rhizoma Zingiberis 8-16 part, Rhizoma Coptidis 8-16 part, Radix Scutellariae 8-16 part, Rhizoma Cynanchi Stauntonii 5-13 part, Radix Peucedani 5-13 part, Cortex Magnoliae Officinalis 5-13 part, Pericarpium Arecae 5-13 part, Endoconcha Sepiae 5-13 part, Concha Arcae (calcined) 8-16 part, Fructus Perillae 5-13 part, Fructus Cannabis 8-16 part, Radix Glycyrrhizae 4-8 part.
Preferably, the Chinese medicine of above-mentioned treatment intermingling cold and heat gastroesophageal reflux disease, is made up of the Chinese medicine of following weight portion:
Rhizoma Pinelliae 7-11 part, Rhizoma Zingiberis 10-14 part, Rhizoma Coptidis 10-14 part, Radix Scutellariae 10-14 part, Rhizoma Cynanchi Stauntonii 7-11 part, Radix Peucedani 7-11 part, Cortex Magnoliae Officinalis 7-11 part, Pericarpium Arecae 7-11 part, Endoconcha Sepiae 7-11 part, Concha Arcae (calcined) 10-14 part, Fructus Perillae 7-11 part, Fructus Cannabis 10-14 part, Radix Glycyrrhizae 5-7 part.
Preferred, the Chinese medicine of above-mentioned treatment intermingling cold and heat gastroesophageal reflux disease, is made up of the Chinese medicine of following weight portion:
The Rhizoma Pinelliae 9 parts, Rhizoma Zingiberis 12 parts, Rhizoma Coptidis 12 parts, Radix Scutellariae 12 parts, Rhizoma Cynanchi Stauntonii 9 parts, Radix Peucedani 9 parts, Cortex Magnoliae Officinalis 9 parts, Pericarpium Arecae 9 parts, Endoconcha Sepiae 9 parts, Concha Arcae (calcined) 12 parts, Fructus Perillae 9 parts, Fructus Cannabis 12 parts, 6 parts, Radix Glycyrrhizae.
The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.
The weight portion of said medicine, if in units of g, the normally consumption of 1 dose.
The indication of Chinese medicine of the present invention: be used for the treatment of intermingling cold and heat gastroesophageal reflux disease.
The taboo item of Chinese medicine of the present invention: the fasting for the treatment of period in a medicine is greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food.
The Chinese medicine related in prescriptions of Chinese medicine of the present invention all records in Chinese Pharmacopoeia 2010 editions.
Gastroesophageal reflux disease belongs to the category of Chinese medicine " acid regurgitation ", and Chinese medicine thinks that gastroesophageal reflux disease is many by invading in eating and drinking without temperance, disorder of emotion, weakness of the spleen and stomach, exopathogen etc. caused by reason., mainly at stomach and esophagus, there is close relationship sick position with spleen, liver, lung.Esophagus is swallowed certainly to stomach, by stomach is led.Esophagus is connected with stomach downwards, and its mechanism of qi is suitable to reduce to.Primary disease pathogenesis is stomach-QI being unable to descend normally, adverse rising of stomach-QI.Clinical discovery simultaneous occurrence of cold and heat syndromes is the different TCM syndrome types of gastroesophageal reflux; For intermingling cold and heat gastroesophageal reflux disease, should with pungent drugs can disperse and bitter drugs can descend, sending down the abnormal ascending QI purging FU-organs is therapeutic rules.
Chinese prescription mechanism of the present invention is as follows:
Monarch drug: the Rhizoma Pinelliae, Rhizoma Zingiberis merit are fallen apart with pungent temperature rise; Rhizoma Coptidis, Radix Scutellariae merit are with bitter cold pathogenic fire purging; Four medicines share, mildly regulating cold and heat, stopping nausea and vomiting by lowering the adverse flow of QI.
Ministerial drug: Rhizoma Cynanchi Stauntonii, Radix Peucedani merit with lowering the adverse-rising QI to resolve phlegm, stopping nausea and vomiting by lowering the adverse flow of QI; Cortex Magnoliae Officinalis, Pericarpium Arecae merit are to regulate the flow of vital energy except full; Endoconcha Sepiae, Concha Arcae (calcined) merit are with relieving gastric hyperacidity to alleviate stomachache.
Adjuvant drug: Fructus Perillae, Fructus Cannabis merit are with lowering the adverse-rising QI to resolve phlegm, and intestine moistening purging FU-organs, helps recovery mechanism of qi unobstructed.
Make medicine: Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.
We's compatibility is reasonable, and all medicines share plays pungent drugs can disperse and bitter drugs can descend altogether, the effect of sending down the abnormal ascending QI purging FU-organs, and the pathogenesis of the gastroesophageal reflux disease that links closely syndrome of incoordination between liver and stomach, obviously can improve symptom, and improve patients ' life quality, achieve good clinical efficacy, clinic is applied.
detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.
Embodiment 1
Treat a Chinese medicine for intermingling cold and heat gastroesophageal reflux disease, each crude drug weight proportion is as follows:
Rhizoma Pinelliae 9g, Rhizoma Zingiberis 12g, Rhizoma Coptidis 12g, Radix Scutellariae 12g, Rhizoma Cynanchi Stauntonii 9g, Radix Peucedani 9g, Cortex Magnoliae Officinalis 9g, Pericarpium Arecae 9g, Endoconcha Sepiae 9g, Concha Arcae (calcined) 12g, Fructus Perillae 9g, Fructus Cannabis 12g, Radix Glycyrrhizae 6g.
Embodiment 2
Treat a Chinese medicine for intermingling cold and heat gastroesophageal reflux disease, each crude drug weight proportion is as follows:
Rhizoma Pinelliae 7g, Rhizoma Zingiberis 14g, Rhizoma Coptidis 10g, Radix Scutellariae 14g, Rhizoma Cynanchi Stauntonii 7g, Radix Peucedani 11g, Cortex Magnoliae Officinalis 7g, Pericarpium Arecae 11g, Endoconcha Sepiae 7g, Concha Arcae (calcined) 14g, Fructus Perillae 7g, Fructus Cannabis 14g, Radix Glycyrrhizae 5g.
Embodiment 3
Treat a Chinese medicine for intermingling cold and heat gastroesophageal reflux disease, each crude drug weight proportion is as follows:
Rhizoma Pinelliae 11g, Rhizoma Zingiberis 10g, Rhizoma Coptidis 14g, Radix Scutellariae 10g, Rhizoma Cynanchi Stauntonii 11g, Radix Peucedani 7g, Cortex Magnoliae Officinalis 11g, Pericarpium Arecae 7g, Endoconcha Sepiae 11g, Concha Arcae (calcined) 10g, Fructus Perillae 11g, Fructus Cannabis 10g, Radix Glycyrrhizae 7g.
Embodiment 4
Treat a Chinese medicine for intermingling cold and heat gastroesophageal reflux disease, each crude drug weight proportion is as follows:
Rhizoma Pinelliae 5g, Rhizoma Zingiberis 16g, Rhizoma Coptidis 8g, Radix Scutellariae 16g, Rhizoma Cynanchi Stauntonii 5g, Radix Peucedani 13g, Cortex Magnoliae Officinalis 5g, Pericarpium Arecae 13g, Endoconcha Sepiae 5g, Concha Arcae (calcined) 16g, Fructus Perillae 5g, Fructus Cannabis 16g, Radix Glycyrrhizae 4g.
Embodiment 5
Treat a Chinese medicine for intermingling cold and heat gastroesophageal reflux disease, each crude drug weight proportion is as follows:
Rhizoma Pinelliae 13g, Rhizoma Zingiberis 8g, Rhizoma Coptidis 16g, Radix Scutellariae 8g, Rhizoma Cynanchi Stauntonii 13g, Radix Peucedani 5g, Cortex Magnoliae Officinalis 13g, Pericarpium Arecae 5g, Endoconcha Sepiae 13g, Concha Arcae (calcined) 8g, Fructus Perillae 13g, Fructus Cannabis 8g, Radix Glycyrrhizae 8g.
Carried out clinical pharrnacokinetics test to Chinese medicine of the present invention, Details as Follows:
1. data and method
1.1 object of study
Choose 150 routine gastroesophageal reflux disease simultaneous occurrence of cold and heat syndromes patients.
1.2 diagnostic criteria
Western medicine diagnose standard: reference year Montreal, CAN is about the global National Consensus reached and China's in October, 2003 " reflux esophagitis Treatment and diagnosis guide ".
Tcm syndrome standard: with reference to China Association of Traditional Chinese Medicine's the spleen-stomach disease branch year promulgate " traditional Chinese medical science disease for digest practice guidelines " in reflux esophagitis simultaneous occurrence of cold and heat syndromes TCM syndrome diagnostic criteria, primary symptom: after (1) breastbone or stomach amine portion burn discomfort; (2) acid regurgitation or general vomiting watery fluid; (3) dull pain at the bottom of stomach, likes warm pain relieved by pressing; (4) stomachache on an empty stomach, obtains food alleviation of pain.Secondary disease: (1) inappetence; (2) spiritlessness and weakness; (3) the stool pool is thin; (4) hands and feet being not warm.Tongue pulse condition: red tongue, tongue is white, deficient and weak pulse.Tongue pulse condition meets, and possesses primary symptom 2 and can be diagnosed as simultaneous occurrence of cold and heat syndromes with time disease 1 or 2.
1.3 inclusive criteria
(1) age 18-65 year, male or female; (2) be reflux esophagitis through endoscopic diagnosis, or reflux diseases questionnaire integration must be greater than 12 points; (3) traditional Chinese medical science " coldheat complex " syndrome diagnostic criterion is met; (4) Informed Consent Form is signed.
1.4 exclusion standard
(1) digestive tract tumor; (2) cardiovascular and cerebrovascular vessel, Liver and kidney, endocrine, hemopoietic system severe primary Disease is associated with; (3) gestation or women breast-feeding their children; (4) allergic constitution person is associated with serious neurological, psychologic factors person; (5) near month, other clinical trial person is participated in.
1.5 Therapeutic Method
Give Chinese medicine of the present invention: Rhizoma Pinelliae 9g, Rhizoma Zingiberis 12g, Rhizoma Coptidis 12g, Radix Scutellariae 12g, Rhizoma Cynanchi Stauntonii 9g, Radix Peucedani 9g, Cortex Magnoliae Officinalis 9g, Pericarpium Arecae 9g, Endoconcha Sepiae 9g, Concha Arcae (calcined) 12g, Fructus Perillae 9g, Fructus Cannabis 12g, Radix Glycyrrhizae 6g; Be decocted in water for oral dose, day potion, sooner or later sub-service was a course for the treatment of with 2 weeks.
1.6 observation index
Reflux diseases questionnaire (RDQ): scale is totally divided into symptom frequency and degree two parts, scale total score minimum for point, be up to point symptom frequency and degree integration minimum be 0 point, be up to 40 points.
Quality of life scale (SF-36): eight aspects, i.e. physiological functions of Scale assessment, physiological function, body pain, general health, vigor, social function, emotion function, Mental Health.Each dimension scores makes its value within the scope of 0-100 by conversion, and score higher quality of life is higher.
1.7 clinical efficacy evaluations
Recovery from illness: symptom, sign disappear or substantially disappear, RDQ total score reduces >=95%;
Effective: symptom, sign are obviously improved, RDQ total score reduces >=70%, but <95%;
Effective: symptom, sign all take a favorable turn, RDQ total score reduces >=30%, but <70%
Invalid: symptom, sign are all without being clearly better, even increase the weight of, RDQ total score reduces <30%.
1.8 statistical method
Adopt SPSS14.0 software kit to carry out statistical analysis, measurement data adopts mean plus-minus standard deviation to represent, compare employing paired-sample t test before and after treatment, P<0.05 represents that difference has statistical significance.
2. result
RDQ scoring before and after 2.1 treatments
Before treatment, average RDQ scoring is (23.77 ± 5.34) point, and be reduced to after treatment (3.21 ± 1.63) point, difference has statistical significance (P<0.05).
SF-36 scoring before and after 2.2 treatments
Before treatment, average SF-36 scoring is (44.05 ± 5.25) point, and raise after treatment as (91.56 ± 4.43) point, difference has statistical significance (P<0.05).
2.3 clinical efficacy
In 150 routine patients, cure 79 examples, effective 52 examples, effective 15 examples, invalid 4 examples; Cure rate 52.7%, total obvious effective rate 87.3%, total effective rate 97.3%.
Claims (3)
1. treat a Chinese medicine for intermingling cold and heat gastroesophageal reflux disease, be made up of the Chinese medicine of following weight portion:
Rhizoma Pinelliae 5-13 part, Rhizoma Zingiberis 8-16 part, Rhizoma Coptidis 8-16 part, Radix Scutellariae 8-16 part, Rhizoma Cynanchi Stauntonii 5-13 part, Radix Peucedani 5-13 part, Cortex Magnoliae Officinalis 5-13 part, Pericarpium Arecae 5-13 part, Endoconcha Sepiae 5-13 part, Concha Arcae (calcined) 8-16 part, Fructus Perillae 5-13 part, Fructus Cannabis 8-16 part, Radix Glycyrrhizae 4-8 part.
2. the Chinese medicine for the treatment of intermingling cold and heat gastroesophageal reflux disease according to claim 1, is characterized in that, be made up of the Chinese medicine of following weight portion:
Rhizoma Pinelliae 7-11 part, Rhizoma Zingiberis 10-14 part, Rhizoma Coptidis 10-14 part, Radix Scutellariae 10-14 part, Rhizoma Cynanchi Stauntonii 7-11 part, Radix Peucedani 7-11 part, Cortex Magnoliae Officinalis 7-11 part, Pericarpium Arecae 7-11 part, Endoconcha Sepiae 7-11 part, Concha Arcae (calcined) 10-14 part, Fructus Perillae 7-11 part, Fructus Cannabis 10-14 part, Radix Glycyrrhizae 5-7 part.
3. the Chinese medicine for the treatment of intermingling cold and heat gastroesophageal reflux disease according to claim 3, is characterized in that, be made up of the Chinese medicine of following weight portion:
The Rhizoma Pinelliae 9 parts, Rhizoma Zingiberis 12 parts, Rhizoma Coptidis 12 parts, Radix Scutellariae 12 parts, Rhizoma Cynanchi Stauntonii 9 parts, Radix Peucedani 9 parts, Cortex Magnoliae Officinalis 9 parts, Pericarpium Arecae 9 parts, Endoconcha Sepiae 9 parts, Concha Arcae (calcined) 12 parts, Fructus Perillae 9 parts, Fructus Cannabis 12 parts, 6 parts, Radix Glycyrrhizae.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105055746A (en) * | 2015-07-31 | 2015-11-18 | 济南邦文医药科技有限公司 | Traditional Chinese medicine capable of treating liver-stomach disharmony type gastroesophageal reflux disease |
CN112675276A (en) * | 2021-01-07 | 2021-04-20 | 山西中医药大学附属医院 | Medicine for treating gastroesophageal reflux disease and preparation method thereof |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105055746A (en) * | 2015-07-31 | 2015-11-18 | 济南邦文医药科技有限公司 | Traditional Chinese medicine capable of treating liver-stomach disharmony type gastroesophageal reflux disease |
CN112675276A (en) * | 2021-01-07 | 2021-04-20 | 山西中医药大学附属医院 | Medicine for treating gastroesophageal reflux disease and preparation method thereof |
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Application publication date: 20151118 |