CN105056111A - Traditional Chinese medicinal pill for treating hodgkin lymphoma - Google Patents

Abstract

The invention relates to a traditional Chinese medicinal pill for treating hodgkin lymphoma. The medicinal pill is prepared by mixing the following traditional Chinese medicines in parts by mass: 20 parts of honeysuckle, 15 parts of radix scrophulariae, 15 parts of fructus trichosanthis, 12 parts of seaweed, 12 parts of kelp, 15 parts of radix rehmanniae, 12 parts of radix curcumae, 15 parts of safflower, 12 parts of root of bidentate achyranthes, 15 parts of endothelium corneum gigeriae galli, 15 parts of angelica, 20 parts of Chinese lobelia herb, 12 parts of mustard seed and 100 parts of coix seed. The inventor analyzes that hodgkin lymphoma is caused by stasis of phlegm, qi and blood and stagnation of liver qi from the viewpoint of traditional Chinese medicine; in addition, hodgkin lymphoma may be also caused by accumulation of damp-heat in blood, stasis of phlegm in blood vessels and mass formed by accumulation; and the medicinal pill, which is prepared by combining traditional Chinese medicines which are capable of clearing away heat and toxic materials, regulating qi-flowing for eliminating phlegm, promoting blood circulation and removing blood stasis and by using coix seed which is relatively high in starch content as an adhesive, is significant in treatment effect and convenient to take.

Description

A kind of Chinese medicine pill for the treatment of Hodgkin lymphoma

Technical field

The present invention relates to a kind of Chinese medicine pill for the treatment of Hodgkin lymphoma, relate generally to each Chinese medicine constituent in this Chinese medicine pill, belong to medicine technology field.

Background technology

Hodgkin lymphoma (HodgkinLymphoma), was once called as lymphogranulomatosis, Hokdkin disease, or He Jiejin lymphomas.It comes from lymphocytic a kind of canceration.The name of " Huo Qijin " comes from ThomasHodgkin at first malignant disease describing this lymphsystem uniqueness in 1832.It often starts to betide one group of lymph node, is then diffused into other lymph nodes or knot outer organ, tissue.Its Histopathological Characteristics is the appearance of pernicious Reed-Sternberg (inner-Si) cell.Hodgkin lymphoma is one of modal malignant tumor in adolescence.Pathological changes mainly occurs in lymph node, with cervical lymph node and supraclavicular lymph nodes the most common, be secondly after mediastinum, peritoneum, paraaortic lymph nodes.Pathological changes is from one or one group of lymph node, and performance is sent out to the regular done site by site of contiguous lymph node along lymphatic channel by primary tumor usually.Can there is hematogenous spread in late period, invade blood vessel, involve the positions such as spleen, liver, bone marrow and digestive tract.Hodgkin lymphoma accounts for 0.1% ~ 0.2% of whole tumor.Annual morbidity 1/10 ten thousand ~ 4,/10 ten thousand population, more rare in Asia.China Shanghai City statistical standard annual morbidity 1.1/10 ten thousand population in 1989, accounts for 16.5% ~ 22.5% (western countries are 34.6% ~ 51.6%) in lymphoma.Male is more than women (1.3 ~ 1.4:1).Age of onset developed country is bimodal distribution, and the 1st age peak was at 15 ~ 35 years old, and the 2nd age peak is after 55 years old.China and Japan's morbidity, without the bimodal distribution at age, are sent out patient and mostly are about 40 years old.

The Hodgkin lymphoma cause of disease is mainly viral infection, and relevant expert once said that in patients serum, EBV antibody titer increases, and thought and infects relevant with EBV.Nearest Herbst etc. apply polymerase chain reaction,PCR (PCR) technology and carry out EBVDNA Sequence Detection to 198 routine Hodgkin lymphomas are freezing with paraffin-embedded tissue, and result has 50% positive.Another in situ hybridization proves, in R-S cell, EBVDNA is positive.This more illustrates that Epstein-Barr virus is the factor promoting to produce.

The treatment of Hodgkin lymphoma, at present, the application in Hodgkin lymphoma treatment of chemotherapy, radiotherapy and bone marrow transplantation, makes it become the tumor that can cure.In conjunction with traditional Chinese medical herbal treatment while modern medicine chemotherapy, radiotherapy, operation, Hodgkin lymphoma cure rate is made greatly to increase especially.

Summary of the invention

With Chinese medicine viewpoint analysis Hodgkin lymphoma, the cause of disease is that gas, blood, expectorant stasis blocking are stagnant, depression of liver-QI, and body fluid can not defeated cloth, be condensed into expectorant, the stagnation of QI can cause blood stasis with the passing of time again, and gas, expectorant, blood stasis three condense mutually and form lump, in addition, damp and hotly be hidden in blood system, stagnation of phlegm blood network, also can lump formation due to accumulation of pathogens.Treatment Hodgkin lymphoma, with the Chinese Medicine and Clavicular of heat-clearing and toxic substances removing, activating QI to eliminate phlegm, blood circulation promoting and blood stasis dispelling, and should be made into pill, facilitate patients.

A kind of Chinese medicine pill for the treatment of Hodgkin lymphoma taked technical scheme of dealing with problems becomes pill by each Chinese medicine quality part below than mixing manufacture: Flos Lonicerae 20 parts, Radix Scrophulariae 15 parts, Fructus Trichosanthis 15 parts, Sargassum 12 parts, Thallus Laminariae (Thallus Eckloniae) 12 parts, 15 parts, the Radix Rehmanniae, Radix Curcumae 12 parts, 15 parts, Flos Carthami, Radix Achyranthis Bidentatae 12 parts, Endothelium Corneum Gigeriae Galli 15 parts, Radix Angelicae Sinensis 15 parts, Herba Lobeliae Chinensis 20 parts, Semen Brassicae Junceae 12 parts, Semen Coicis 100 parts.

Lower surface analysis one treats each herbal nature effect in the lymphadenomatous Chinese medicine pill of Huo Jinqi.Flos Lonicerae antipyretic and antidote functions is quite strong, for there being the sore and toxic of red and swollen heat pain, controls epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.Radix Scrophulariae cures mainly epidemic febrile disease and nutrient blood, fever of the body, excessive thirst, crimson tongue, send out speckle, hectic fever due to YIN-deficiency chronic cough, fidgets due to deficiency not awake, Tianjin hinder constipation, order puckery dim-sighted, throat larynx swells and ache, scrofula sucutaneous nodule, skin sore.Fructus Trichosanthis loosening bowel to relieve constipation, heat-transformation expectorant, controls the thoracic obstruction, and Fructus Trichosanthis has certain inhibitory action to cancer, belongs to Chinese medicine medicine for preventing.Sargassum softening the hard mass, expectorant, diuretic, detumescent.Containing abundant iodine in Sargassum, to thyromegaly, thyroid function is abnormal, and neck submental lymph nodes tuberculosis has specially good effect.The propagation of the close glycoprotein energy inhibition tumor cell contained in Sargassum, can change eliminating stagnation gas carbuncle, abdomen inner product block.Thallus Laminariae (Thallus Eckloniae) gas raw meat, salty in the mouth, returns liver, stomach, kidney channel, has hard masses softening and resolving, expectorant, the function of diuretic, for phlegm retention edema, hard masses softening and resolving, goiter, scrofula.Radix Rehmanniae clearing away heat and promoting production of body fluid, removing heat from blood, hemostasis.For consumption of YIN caused by febrile disease, crimson tongue excessive thirst, sends out speckle dermexanthesis, laryngopharynx swelling and pain.Radix Curcumae promoting QI circulation for relieving depression, removing heat from blood removing blood stasis with potent drugs, control breast abdomen side of body rib all pains, lose that the heart is demented, calentura coma, haematemesis, epistaxis, hematuria, stranguria with blood, jaundice.Flos Carthami promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving, controls amenorrhea ， mass in the abdomen, and difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis are had a pain, carbuncle, injury from falling down.Radix Achyranthis Bidentatae is raw uses dissipating blood stasis blood, subduing inflammation, and control gonorrhea, hematuria, amenorrhea ， mass in the abdomen, difficult labour, retention of placenta, postnatal blood stasis is suffered from abdominal pain, sore throat, carbuncle, traumatic injury; Ripe invigorating the liver and kidney, bone and muscle strengthening, controls waist kneecap pain, spasm of the limbs, flaccidity syndrome and arthralgia syndrome.Endothelium Corneum Gigeriae Galli refers to the gizzard inwall of a chicken, is digestive organs, and for grinding food, these product are one of Chinese medicine, have invigorating the stomach and promoting digestion, and controlling nocturnal emission with astringent drugs is only lost, the multiple efficacies such as treating stranguria fossil.Endothelium Corneum Gigeriae Galli also has the effect of inhibition tumor cell, has good curative effect to gastric cancer, liver cirrhosis.Chinese angelica blood supplementing and blood, menstruction regulating and pain relieving, moisturizes laxation, for blood deficiency, shallow complexion, dizzy cardiopalmus; Blood deficiency, or have the stagnant menoxenia of the stasis of blood, amenorrhea, dysmenorrhea concurrently, the pain such as deficient cold type stomachache, angina pectoris, rheumatic arthralgia, traumatic injury card.Herba Lobeliae Chinensis diuretic, detumescence, removing toxic substances, subcutaneous ulcer of harnessing the Yellow River, edema, tympanites, has loose bowels, dysentery, snakebite, furuncle, toxic swelling, eczema, tinea disease, and osteopatia sprain swells and ache, for extensive abdominal edema, face foot edema, carbuncle furuncle, snake bite and insect sting.Semen Brassicae Junceae property and flavor of peppery and warm, enters lung, stomach warp.Merit is had a monopoly gas eliminating phlegm, warming spleen and stomach for dispelling cold, removing obstruction in the collateral to relieve pain, is usually used in the diseases such as treatment phlegm retention cough with asthma, fullness and distention in the chest and hypochondrium pain, numb limbs and tense tendons, arthralgia, carbuncle of yin nature toxic swelling.Recent study finds, containing number of chemical compositions such as isothiocyanate, erucic acid, aldehydes matter, luxuriant and rich with fragrance fourths in Semen Brassicae Junceae, has the different physiological roles such as anticancer, antibacterial.Semen Coicis spleen invigorating, tonifying the lung, heat clearing away, dampness removing, controls and has loose bowels, arthralgia chiefly caused by damp pathogen, the contracture of muscle arteries and veins, joint stuffiness, edema, beriberi, consumptive lung disease, lung abscess, acute appendicitis, stranguria with turbid discharge, leucorrhea.The kinds of tumors such as ehrlich carcinoma, sarcoma 180 of some extracts to laboratory animal of Semen Coicis all has direct repression, and some compositions can make tumor cell starch degeneration, or make karyokinesis stop at mid-term.In addition, Semen Coicis also has calm, analgesia, cooling, antipyretic, the effect that suppresses Skeletal Muscle Contraction, induce ovulation, blood sugar lowering, antiinflammatory, adrenal cortex reinforcing function, cellular immune function, humoral immune function.In addition, in Semen Coicis, content of starch is maximum, while as cancer therapy drug, is also used as mutually to attach agent to each Chinese medicine, each Chinese medicine can be combined with each other and be pressed into pill.

A kind of Chinese medicine pill beneficial effect of the invention for the treatment of Hodgkin lymphoma is: inventor with the cause of disease of Chinese medicine viewpoint analysis Hodgkin lymphoma be gas, blood, expectorant stasis blocking be stagnant, depression of liver-QI, in addition, damp and hotly be hidden in blood system, stagnation of phlegm blood network, lump formation due to accumulation of pathogens and primary disease, with the Chinese Medicine and Clavicular of heat-clearing and toxic substances removing, activating QI to eliminate phlegm, blood circulation promoting and blood stasis dispelling, and attach agent with the Semen Coicis that content of starch is more and be made into pill, therapeutic effect is remarkable, taking convenience.

Detailed description of the invention

Each raw material of Chinese medicine quality required for a kind of Chinese medicine pill one box 20 ball for the treatment of Hodgkin lymphoma makes is as follows: Flos Lonicerae 20 grams, Radix Scrophulariae 15 grams, Fructus Trichosanthis 15 grams, Sargassum 12 grams, Thallus Laminariae (Thallus Eckloniae) 12 grams, 15 grams, the Radix Rehmanniae, Radix Curcumae 12 grams, 15 grams, Flos Carthami, Radix Achyranthis Bidentatae 12 grams, Endothelium Corneum Gigeriae Galli 15 grams, Radix Angelicae Sinensis 15 grams, Herba Lobeliae Chinensis 20 grams, Semen Brassicae Junceae 12 grams, Semen Coicis 100 grams.

Treat the manufacture method of Chinese medicine pill dosage 20 ball of Hodgkin lymphoma: one, by each Effect of Chinese Medicine Qing wash clean of a dosage, be then dried to hardening; Two, Endothelium Corneum Gigeriae Galli high-temperature baking is turned yellow to detonation; Three, Semen Coicis proper amount of clear water is soaked moistening rear high-temperature maturing, then again that the Semen Coicis after drying of ripening is extremely hardening; Four, by roasted Endothelium Corneum Gigeriae Galli, the dried Semen Coicis of ripening mechanical activation comminution mix homogeneously together with Flos Lonicerae, Radix Scrophulariae, Sargassum, Thallus Laminariae (Thallus Eckloniae), the Radix Rehmanniae, Radix Curcumae, Flos Carthami, Radix Achyranthis Bidentatae, Radix Angelicae Sinensis, Herba Lobeliae Chinensis, Semen Brassicae Junceae; Five, by pulverize after mixed powder machinery be molded into pill and deoxidation sealing.

Claims (1)

1. treat a Chinese medicine pill for Hodgkin lymphoma, it is characterized in that becoming pill by each Chinese medicine quality part below than mixing manufacture: Flos Lonicerae 20 parts, Radix Scrophulariae 15 parts, Fructus Trichosanthis 15 parts, Sargassum 12 parts, Thallus Laminariae (Thallus Eckloniae) 12 parts, 15 parts, the Radix Rehmanniae, Radix Curcumae 12 parts, 15 parts, Flos Carthami, Radix Achyranthis Bidentatae 12 parts, Endothelium Corneum Gigeriae Galli 15 parts, Radix Angelicae Sinensis 15 parts, Herba Lobeliae Chinensis 20 parts, Semen Brassicae Junceae 12 parts, Semen Coicis 100 parts.